SIMILAR PATTERNS OF AMINO ACIDS FOR 5I1N_F_DVAF9

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ao0 GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Bacillus
subtilis) 		PF00156
(Pribosyltran)
PF13522
(GATase_6) 		3 ALA A 258
ASN A 261
LEU A 262
 None
 0.41A 5i1nC-1ao0A:
0.0		 5i1nC-1ao0A:
5.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b5l INTERFERON TAU

(Komagataella
pastoris) 		PF00143
(Interferon) 		3 ALA A  11
ASN A  14
LEU A  15
 None
 0.52A 5i1nC-1b5lA:
0.0		 5i1nC-1b5lA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bik BIKUNIN

(Homo sapiens) 		PF00014
(Kunitz_BPTI) 		3 ALA A  80
ASN A  83
LEU A  84
 None
 0.48A 5i1nC-1bikA:
0.0		 5i1nC-1bikA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1biy LACTOFERRIN

(Bubalus bubalis) 		PF00405
(Transferrin) 		3 ALA A 327
ASN A 330
LEU A 331
 None
 0.45A 5i1nC-1biyA:
0.0		 5i1nC-1biyA:
4.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bue PROTEIN
(IMIPENEM-HYDROLYSIN
G BETA-LACTAMASE)

(Enterobacter
cloacae) 		PF13354
(Beta-lactamase2) 		3 ALA A 286
ASN A 289
LEU A 290
 None
 0.48A 5i1nC-1bueA:
0.0		 5i1nC-1bueA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1by1 PROTEIN (PIX)

(Homo sapiens) 		PF00621
(RhoGEF) 		3 ALA A 182
ASN A 185
LEU A 186
 None
 0.29A 5i1nC-1by1A:
0.0		 5i1nC-1by1A:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f26 NITRIC OXIDE
REDUCTASE

(Fusarium
oxysporum) 		PF00067
(p450) 		3 ALA A 109
ASN A 112
LEU A 113
 None
 0.44A 5i1nC-1f26A:
0.0		 5i1nC-1f26A:
4.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f2h TUMOR NECROSIS
FACTOR RECEPTOR TYPE
1 ASSOCIATED DEATH
DOMAIN PROTEIN

(Homo sapiens) 		PF09034
(TRADD_N) 		3 ALA A 158
ASN A 161
LEU A 162
 None
 0.52A 5i1nC-1f2hA:
0.0		 5i1nC-1f2hA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f59 IMPORTIN BETA-1

(Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		3 ALA A 237
ASN A 240
LEU A 241
 None
 0.51A 5i1nC-1f59A:
undetectable		 5i1nC-1f59A:
6.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f8w NADH PEROXIDASE

(Enterococcus
faecalis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 ALA A 309
ASN A 312
LEU A 313
 None
 0.44A 5i1nC-1f8wA:
undetectable		 5i1nC-1f8wA:
6.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fep FERRIC ENTEROBACTIN
RECEPTOR

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 ALA A  19
ASN A  22
LEU A  23
 None
 0.38A 5i1nC-1fepA:
undetectable		 5i1nC-1fepA:
4.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h29 HIGH-MOLECULAR-WEIGH
T CYTOCHROME C

(Desulfovibrio
vulgaris) 		PF02085
(Cytochrom_CIII) 		3 ALA A 397
ASN A 400
LEU A 401
 None
 0.48A 5i1nC-1h29A:
undetectable		 5i1nC-1h29A:
6.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i4g ENTEROTOXIN TYPE A

(Staphylococcus
aureus) 		PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C) 		3 ALA A  22
ASN A  25
LEU A  26
 None
 0.37A 5i1nC-1i4gA:
undetectable		 5i1nC-1i4gA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iy9 SPERMIDINE SYNTHASE

(Bacillus
subtilis) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		3 ALA A 164
ASN A 166
LEU A 167
 None
 0.51A 5i1nC-1iy9A:
undetectable		 5i1nC-1iy9A:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j9m DD-TRANSPEPTIDASE

(Streptomyces
sp. K15) 		PF00768
(Peptidase_S11) 		3 ALA A 128
ASN A 131
LEU A 132
 None
 0.51A 5i1nC-1j9mA:
undetectable		 5i1nC-1j9mA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jsc ACETOHYDROXY-ACID
SYNTHASE

(Saccharomyces
cerevisiae) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 ALA A 427
ASN A 430
LEU A 431
 FAD  A 701 (-3.5A)
None
None
 0.49A 5i1nC-1jscA:
undetectable		 5i1nC-1jscA:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 ALA A 656
ASN A 657
LEU A 658
 None
 0.48A 5i1nC-1kcwA:
undetectable		 5i1nC-1kcwA:
3.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1khw RNA-DIRECTED RNA
POLYMERASE

(Rabbit
hemorrhagic
disease virus) 		PF00680
(RdRP_1) 		3 ALA A  68
ASN A  71
LEU A  72
 None
 0.47A 5i1nC-1khwA:
undetectable		 5i1nC-1khwA:
5.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kt1 FK506-BINDING
PROTEIN FKBP51

(Saimiri
boliviensis) 		PF00254
(FKBP_C)
PF00515
(TPR_1)
PF13181
(TPR_8) 		3 ALA A 319
ASN A 322
LEU A 323
 None
 0.49A 5i1nC-1kt1A:
undetectable		 5i1nC-1kt1A:
5.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lk0 ARSENATE REDUCTASE

(Staphylococcus
aureus) 		PF01451
(LMWPc) 		3 ALA A  85
ASN A  88
LEU A  89
 None
 0.23A 5i1nC-1lk0A:
undetectable		 5i1nC-1lk0A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n76 LACTOFERRIN

(Homo sapiens) 		PF00405
(Transferrin) 		3 ALA A 327
ASN A 330
LEU A 331
 None
 0.47A 5i1nC-1n76A:
undetectable		 5i1nC-1n76A:
6.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r2f PROTEIN
(RIBONUCLEOTIDE
REDUCTASE R2)

(Salmonella
enterica) 		PF00268
(Ribonuc_red_sm) 		3 ALA A 261
ASN A 264
LEU A 265
 None
 0.52A 5i1nC-1r2fA:
undetectable		 5i1nC-1r2fA:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1si8 CATALASE

(Enterococcus
faecalis) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		3 ALA A 422
ASN A 425
LEU A 426
 None
 0.50A 5i1nC-1si8A:
undetectable		 5i1nC-1si8A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1svf PROTEIN (FUSION
GLYCOPROTEIN)

(Mammalian
rubulavirus 5) 		PF00523
(Fusion_gly) 		3 ALA A 136
ASN A 139
LEU A 140
 None
 0.47A 5i1nC-1svfA:
undetectable		 5i1nC-1svfA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tww DHPS,
DIHYDROPTEROATE
SYNTHASE

(Bacillus
anthracis) 		PF00809
(Pterin_bind) 		3 ALA A 199
ASN A 202
LEU A 203
 None
 0.49A 5i1nC-1twwA:
undetectable		 5i1nC-1twwA:
7.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ucp APOPTOSIS-ASSOCIATED
SPECK-LIKE PROTEIN
CONTAINING A CARD

(Homo sapiens) 		PF02758
(PYRIN) 		3 ALA A  11
ASN A  14
LEU A  15
 None
 0.37A 5i1nC-1ucpA:
undetectable		 5i1nC-1ucpA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT

(Mycobacterium
tuberculosis) 		PF00268
(Ribonuc_red_sm) 		3 ALA A 266
ASN A 269
LEU A 270
 None
 0.51A 5i1nC-1uzrA:
undetectable		 5i1nC-1uzrA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4g GLUTAMATE--CYSTEINE
LIGASE

(Escherichia
coli) 		PF04262
(Glu_cys_ligase) 		3 ALA A 470
ASN A 473
LEU A 474
 None
 0.43A 5i1nC-1v4gA:
undetectable		 5i1nC-1v4gA:
5.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vl4 PMBA-RELATED PROTEIN

(Thermotoga
maritima) 		PF01523
(PmbA_TldD) 		3 ALA A  79
ASN A  82
LEU A  83
 None
 0.49A 5i1nC-1vl4A:
undetectable		 5i1nC-1vl4A:
7.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vqr HYPOTHETICAL PROTEIN
CJ0248

(Campylobacter
jejuni) 		PF08668
(HDOD) 		3 ALA A 277
ASN A 280
LEU A 281
 None
 0.34A 5i1nC-1vqrA:
undetectable		 5i1nC-1vqrA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wpw 3-ISOPROPYLMALATE
DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF00180
(Iso_dh) 		3 ALA A 202
ASN A 205
LEU A 206
 None
 0.46A 5i1nC-1wpwA:
undetectable		 5i1nC-1wpwA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xm9 PLAKOPHILIN 1

(Homo sapiens) 		PF00514
(Arm) 		3 ALA A 550
ASN A 553
LEU A 554
 None
 0.50A 5i1nC-1xm9A:
undetectable		 5i1nC-1xm9A:
7.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xsx SSO10A

(Sulfolobus
solfataricus) 		PF14947
(HTH_45) 		3 ALA A  30
ASN A  31
LEU A  32
 None
 0.51A 5i1nC-1xsxA:
undetectable		 5i1nC-1xsxA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yb2 HYPOTHETICAL PROTEIN
TA0852

(Thermoplasma
acidophilum) 		PF08704
(GCD14) 		3 ALA A 131
ASN A 134
LEU A 135
 None
 0.47A 5i1nC-1yb2A:
undetectable		 5i1nC-1yb2A:
8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yc9 MULTIDRUG RESISTANCE
PROTEIN

(Vibrio cholerae) 		PF02321
(OEP) 		3 ALA A 456
ASN A 459
LEU A 460
 None
 0.50A 5i1nC-1yc9A:
undetectable		 5i1nC-1yc9A:
5.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yw5 PEPTIDYL PROLYL
CIS/TRANS ISOMERASE

(Candida
albicans) 		PF00397
(WW)
PF00639
(Rotamase) 		3 ALA A 151
ASN A 154
LEU A 155
 None
 0.34A 5i1nC-1yw5A:
undetectable		 5i1nC-1yw5A:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7l UBIQUITIN-ACTIVATING
ENZYME E1 1

(Mus musculus) 		PF10585
(UBA_e1_thiolCys) 		3 ALA A 864
ASN A 867
LEU A 868
 None
 0.51A 5i1nC-1z7lA:
undetectable		 5i1nC-1z7lA:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zp6 HYPOTHETICAL PROTEIN
ATU3015

(Agrobacterium
fabrum) 		PF13238
(AAA_18) 		3 ALA A  28
ASN A  31
LEU A  32
 None
 0.31A 5i1nC-1zp6A:
undetectable		 5i1nC-1zp6A:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2as0 HYPOTHETICAL PROTEIN
PH1915

(Pyrococcus
horikoshii) 		PF01472
(PUA)
PF10672
(Methyltrans_SAM) 		3 ALA A 320
ASN A 323
LEU A 324
 None
 0.48A 5i1nC-2as0A:
undetectable		 5i1nC-2as0A:
7.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btv PROTEIN (VP3 CORE
PROTEIN)

(Bluetongue
virus) 		PF01700
(Orbi_VP3) 		3 ALA A 650
ASN A 653
LEU A 654
 None
 0.48A 5i1nC-2btvA:
undetectable		 5i1nC-2btvA:
4.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1h DELTA-AMINOLEVULINIC
ACID DEHYDRATASE

(Prosthecochloris
vibrioformis) 		PF00490
(ALAD) 		3 ALA A  21
ASN A  24
LEU A  25
 None
 0.46A 5i1nC-2c1hA:
undetectable		 5i1nC-2c1hA:
6.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c2l CARBOXY TERMINUS OF
HSP70-INTERACTING
PROTEIN

(Mus musculus) 		PF04564
(U-box)
PF12895
(ANAPC3) 		3 ALA A 114
ASN A 117
LEU A 118
 None
SO4  A1306 (-3.8A)
None
 0.48A 5i1nC-2c2lA:
undetectable		 5i1nC-2c2lA:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfz SDS HYDROLASE SDSA1

(Pseudomonas
aeruginosa) 		PF00753
(Lactamase_B)
PF14863
(Alkyl_sulf_dimr)
PF14864
(Alkyl_sulf_C) 		3 ALA A  99
ASN A 102
LEU A 103
 None
 0.42A 5i1nC-2cfzA:
undetectable		 5i1nC-2cfzA:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cw3 IRON SUPEROXIDE
DISMUTASE

(Perkinsus
marinus) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		3 ALA A 199
ASN A 202
LEU A 203
 None
 0.41A 5i1nC-2cw3A:
undetectable		 5i1nC-2cw3A:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ds2 SWEET PROTEIN
MABINLIN-2 CHAIN B

(Capparis
masaikai) 		PF00234
(Tryp_alpha_amyl) 		3 ALA B  51
ASN B  54
LEU B  55
 None
 0.23A 5i1nC-2ds2B:
undetectable		 5i1nC-2ds2B:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ebm RWD
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF05773
(RWD) 		3 ALA A  98
ASN A 101
LEU A 102
 None
 0.48A 5i1nC-2ebmA:
undetectable		 5i1nC-2ebmA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ehh DIHYDRODIPICOLINATE
SYNTHASE

(Aquifex
aeolicus) 		PF00701
(DHDPS) 		3 ALA A  22
ASN A  25
LEU A  26
 None
 0.48A 5i1nC-2ehhA:
undetectable		 5i1nC-2ehhA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9h PTS SYSTEM, IIA
COMPONENT

(Enterococcus
faecalis) 		PF03829
(PTSIIA_gutA) 		3 ALA A  74
ASN A  77
LEU A  78
 None
 0.49A 5i1nC-2f9hA:
undetectable		 5i1nC-2f9hA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fgc ACETOLACTATE
SYNTHASE, SMALL
SUBUNIT

(Thermotoga
maritima) 		PF01842
(ACT)
PF10369
(ALS_ss_C) 		3 ALA A 161
ASN A 164
LEU A 165
 None
 0.46A 5i1nC-2fgcA:
undetectable		 5i1nC-2fgcA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7c BETA-GLUCOSIDASE A

(Thermotoga
maritima) 		PF00232
(Glyco_hydro_1) 		3 ALA A 193
ASN A 196
LEU A 197
 None
 0.52A 5i1nC-2j7cA:
undetectable		 5i1nC-2j7cA:
6.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kn6 APOPTOSIS-ASSOCIATED
SPECK-LIKE PROTEIN
CONTAINING A CARD

(Homo sapiens) 		PF00619
(CARD)
PF02758
(PYRIN) 		3 ALA A  11
ASN A  14
LEU A  15
 None
 0.52A 5i1nC-2kn6A:
undetectable		 5i1nC-2kn6A:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l3y INTERLEUKIN-6

(Mus musculus) 		PF00489
(IL6) 		3 ALA A  63
ASN A  66
LEU A  67
 None
 0.45A 5i1nC-2l3yA:
undetectable		 5i1nC-2l3yA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n4k ENTEROCIN-HF

(Enterococcus
faecium) 		PF01721
(Bacteriocin_II) 		3 ALA A  29
ASN A  32
LEU A  33
 None
 0.48A 5i1nC-2n4kA:
undetectable		 5i1nC-2n4kA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nwq PROBABLE SHORT-CHAIN
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00106
(adh_short) 		3 ALA A  68
ASN A  71
LEU A  72
 None
 0.26A 5i1nC-2nwqA:
undetectable		 5i1nC-2nwqA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o5a BH1328 PROTEIN

(Bacillus
halodurans) 		PF02410
(RsfS) 		3 ALA A  96
ASN A  99
LEU A 100
 None
 0.43A 5i1nC-2o5aA:
undetectable		 5i1nC-2o5aA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfi CHLORIDE CHANNEL
PROTEIN CLC-KA

(Homo sapiens) 		PF00571
(CBS) 		3 ALA A 676
ASN A 679
LEU A 680
 CL  A 504 ( 4.2A)
CL  A 504 ( 4.8A)
None
 0.37A 5i1nC-2pfiA:
undetectable		 5i1nC-2pfiA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pkg SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
65 KDA REGULATORY
SUBUNIT A ALPHA
ISOFORM

(Homo sapiens) 		PF02985
(HEAT)
PF13646
(HEAT_2) 		3 ALA A 286
ASN A 289
LEU A 290
 None
 0.48A 5i1nC-2pkgA:
undetectable		 5i1nC-2pkgA:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qb6 EXOPOLYPHOSPHATASE

(Saccharomyces
cerevisiae) 		PF01368
(DHH)
PF02833
(DHHA2) 		3 ALA A 391
ASN A 394
LEU A 395
 None
 0.25A 5i1nC-2qb6A:
undetectable		 5i1nC-2qb6A:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qm1 GLUCOKINASE

(Enterococcus
faecalis) 		PF00480
(ROK) 		3 ALA A 250
ASN A 253
LEU A 254
 None
 0.35A 5i1nC-2qm1A:
undetectable		 5i1nC-2qm1A:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qna IMPORTIN SUBUNIT
BETA-1

(Homo sapiens) 		PF13513
(HEAT_EZ) 		3 ALA A 237
ASN A 240
LEU A 241
 None
 0.50A 5i1nC-2qnaA:
undetectable		 5i1nC-2qnaA:
3.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qt6 LACCASE

(Lentinus
tigrinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 ALA A 482
ASN A 485
LEU A 486
 None
 0.37A 5i1nC-2qt6A:
undetectable		 5i1nC-2qt6A:
6.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qv6 GTP CYCLOHYDROLASE
III

(Methanocaldococcus
jannaschii) 		PF05165
(GCH_III) 		3 ALA A  36
ASN A  39
LEU A  40
 None
 0.50A 5i1nC-2qv6A:
undetectable		 5i1nC-2qv6A:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r48 PHOSPHOTRANSFERASE
SYSTEM (PTS)
MANNOSE-SPECIFIC
ENZYME IIBCA
COMPONENT

(Bacillus
subtilis) 		PF02302
(PTS_IIB) 		3 ALA A  19
ASN A  22
LEU A  23
 None
 0.49A 5i1nC-2r48A:
undetectable		 5i1nC-2r48A:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v5d O-GLCNACASE NAGJ

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C)
PF02838
(Glyco_hydro_20b)
PF07555
(NAGidase) 		3 ALA A 535
ASN A 538
LEU A 539
 None
 0.44A 5i1nC-2v5dA:
undetectable		 5i1nC-2v5dA:
7.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vak SIGMA A

(Avian
orthoreovirus) 		PF03084
(Sigma_1_2) 		3 ALA A 295
ASN A 298
LEU A 299
 None
 0.50A 5i1nC-2vakA:
undetectable		 5i1nC-2vakA:
5.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vf1 CAPSID PROTEIN

(Rabbit
picobirnavirus) 		no annotation 3 ALA A 227
ASN A 230
LEU A 231
 None
 0.46A 5i1nC-2vf1A:
undetectable		 5i1nC-2vf1A:
7.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vf8 EXCINUCLEASE ABC
SUBUNIT A

(Deinococcus
radiodurans) 		PF00005
(ABC_tran) 		3 ALA A 423
ASN A 426
LEU A 427
 None
 0.47A 5i1nC-2vf8A:
undetectable		 5i1nC-2vf8A:
3.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpw THIOSULFATE
REDUCTASE

(Thermus
thermophilus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		3 ALA A 455
ASN A 458
LEU A 459
 None
 0.46A 5i1nC-2vpwA:
undetectable		 5i1nC-2vpwA:
4.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wv0 HTH-TYPE
TRANSCRIPTIONAL
REPRESSOR YVOA

(Bacillus
subtilis) 		PF00392
(GntR)
PF07702
(UTRA) 		3 ALA A  54
ASN A  57
LEU A  58
 None
 0.48A 5i1nC-2wv0A:
undetectable		 5i1nC-2wv0A:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x5f ASPARTATE_TYROSINE_P
HENYLALANINE
PYRIDOXAL-5'
PHOSPHATE-DEPENDENT
AMINOTRANSFERASE

(Staphylococcus
aureus) 		PF00155
(Aminotran_1_2) 		3 ALA A 250
ASN A 253
LEU A 254
 None
 0.24A 5i1nC-2x5fA:
undetectable		 5i1nC-2x5fA:
6.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhe UNC18

(Monosiga
brevicollis) 		PF00995
(Sec1) 		3 ALA A 438
ASN A 441
LEU A 442
 None
 0.41A 5i1nC-2xheA:
undetectable		 5i1nC-2xheA:
4.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xtq COLICIN-M

(Escherichia
coli) 		PF14859
(Colicin_M) 		3 ALA A  86
ASN A  89
LEU A  90
 None
 0.49A 5i1nC-2xtqA:
undetectable		 5i1nC-2xtqA:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zws NEUTRAL CERAMIDASE

(Pseudomonas
aeruginosa) 		PF04734
(Ceramidase_alk)
PF17048
(Ceramidse_alk_C) 		3 ALA A 109
ASN A 112
LEU A 113
 GOL  A 655 (-3.7A)
None
None
 0.44A 5i1nC-2zwsA:
undetectable		 5i1nC-2zwsA:
5.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aay PUTATIVE THIOSULFATE
SULFURTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00581
(Rhodanese) 		3 ALA A  13
ASN A  16
LEU A  17
 None
 0.45A 5i1nC-3aayA:
undetectable		 5i1nC-3aayA:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afe HYDROXYLASE,
PUTATIVE

(Mycobacterium
tuberculosis) 		PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2) 		3 ALA A  15
ASN A  18
LEU A  19
 None
 0.40A 5i1nC-3afeA:
undetectable		 5i1nC-3afeA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE

(Micrococcus
luteus) 		PF00348
(polyprenyl_synt) 		3 ALA B 243
ASN B 246
LEU B 247
 None
 0.48A 5i1nC-3aqcB:
undetectable		 5i1nC-3aqcB:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgh SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12741
(SusD-like) 		3 ALA A  47
ASN A  50
LEU A  51
 None
 0.51A 5i1nC-3cghA:
undetectable		 5i1nC-3cghA:
5.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cr3 PTS-DEPENDENT
DIHYDROXYACETONE
KINASE, ADP-BINDING
SUBUNIT DHAL

(Lactococcus
lactis) 		PF02734
(Dak2) 		3 ALA A 140
ASN A 144
LEU A 145
 None
 0.44A 5i1nC-3cr3A:
undetectable		 5i1nC-3cr3A:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cr3 PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
PHOSPHOTRANSFERASE
SUBUNIT DHAM

(Lactococcus
lactis) 		PF03610
(EIIA-man) 		3 ALA C  70
ASN C  73
LEU C  74
 None
 0.41A 5i1nC-3cr3C:
undetectable		 5i1nC-3cr3C:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d00 TUNGSTEN
FORMYLMETHANOFURAN
DEHYDROGENASE
SUBUNIT E

(Syntrophus
aciditrophicus) 		PF02663
(FmdE) 		3 ALA A  39
ASN A  42
LEU A  43
 None
 0.21A 5i1nC-3d00A:
undetectable		 5i1nC-3d00A:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d79 PUTATIVE
UNCHARACTERIZED
PROTEIN PH0734

(Pyrococcus
horikoshii) 		PF01472
(PUA)
PF09183
(DUF1947) 		3 ALA A  73
ASN A  76
LEU A  77
 None
 0.47A 5i1nC-3d79A:
undetectable		 5i1nC-3d79A:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dra GERANYLGERANYLTRANSF
ERASE TYPE I BETA
SUBUNIT

(Candida
albicans) 		PF00432
(Prenyltrans) 		3 ALA B 100
ASN B 103
LEU B 104
 None
 0.51A 5i1nC-3draB:
undetectable		 5i1nC-3draB:
6.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7h DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Vibrio cholerae) 		no annotation 3 ALA A  94
ASN A  97
LEU A  98
 None
 0.41A 5i1nC-3e7hA:
undetectable		 5i1nC-3e7hA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ffr PHOSPHOSERINE
AMINOTRANSFERASE
SERC

(Cytophaga
hutchinsonii) 		PF00266
(Aminotran_5) 		3 ALA A  47
ASN A  50
LEU A  51
 None
 0.45A 5i1nC-3ffrA:
undetectable		 5i1nC-3ffrA:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fj1 PUTATIVE
PHOSPHOSUGAR
ISOMERASE

(Ruegeria
pomeroyi) 		PF01380
(SIS) 		3 ALA A 178
ASN A 181
LEU A 182
 None
 0.27A 5i1nC-3fj1A:
undetectable		 5i1nC-3fj1A:
7.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fzy RTX TOXIN RTXA

(Vibrio cholerae) 		PF11713
(Peptidase_C80) 		3 ALA A3475
ASN A3478
LEU A3479
 None
 0.45A 5i1nC-3fzyA:
undetectable		 5i1nC-3fzyA:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g9h SUPPRESSOR OF YEAST
PROFILIN DELETION

(Saccharomyces
cerevisiae) 		PF10291
(muHD) 		3 ALA A 698
ASN A 672
LEU A 671
 None
 0.50A 5i1nC-3g9hA:
undetectable		 5i1nC-3g9hA:
6.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3goz LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN

(Legionella
pneumophila) 		no annotation 3 ALA A 132
ASN A 135
LEU A 136
 None
 0.51A 5i1nC-3gozA:
undetectable		 5i1nC-3gozA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h6p ESAT-6 LIKE PROTEIN
ESXS

(Mycobacterium
tuberculosis) 		PF06013
(WXG100) 		3 ALA A  72
ASN A  75
LEU A  76
 None
 0.23A 5i1nC-3h6pA:
undetectable		 5i1nC-3h6pA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hsy GLUTAMATE RECEPTOR 2

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		3 ALA A 289
ASN A 292
LEU A 293
 None
 0.48A 5i1nC-3hsyA:
undetectable		 5i1nC-3hsyA:
6.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hww 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE-1-CARBOXYLA
TE SYNTHASE

(Escherichia
coli) 		PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
PF16582
(TPP_enzyme_M_2) 		3 ALA A  82
ASN A  85
LEU A  86
 NA  A 564 (-3.2A)
None
None
 0.47A 5i1nC-3hwwA:
undetectable		 5i1nC-3hwwA:
5.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jvv TWITCHING MOBILITY
PROTEIN

(Pseudomonas
aeruginosa) 		PF00437
(T2SSE) 		3 ALA A 288
ASN A 291
LEU A 292
 None
 0.41A 5i1nC-3jvvA:
undetectable		 5i1nC-3jvvA:
7.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k0b PREDICTED
N6-ADENINE-SPECIFIC
DNA METHYLASE

(Listeria
monocytogenes) 		PF01170
(UPF0020)
PF02926
(THUMP) 		3 ALA A  46
ASN A  49
LEU A  50
 None
 0.51A 5i1nC-3k0bA:
undetectable		 5i1nC-3k0bA:
8.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k85 D-GLYCERO-D-MANNO-HE
PTOSE 1-PHOSPHATE
KINASE

(Bacteroides
thetaiotaomicron) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		3 ALA A 317
ASN A 320
LEU A 321
 None
 0.36A 5i1nC-3k85A:
undetectable		 5i1nC-3k85A:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6y CATENIN DELTA-1

(Homo sapiens) 		PF00514
(Arm) 		3 ALA A 727
ASN A 730
LEU A 731
 None
 0.45A 5i1nC-3l6yA:
undetectable		 5i1nC-3l6yA:
4.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llx PREDICTED AMINO ACID
ALDOLASE OR RACEMASE

(Idiomarina
loihiensis) 		PF01168
(Ala_racemase_N)
PF14031
(D-ser_dehydrat) 		3 ALA A 198
ASN A 201
LEU A 202
 None
 0.49A 5i1nC-3llxA:
undetectable		 5i1nC-3llxA:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mve UPF0255 PROTEIN
VV1_0328

(Vibrio
vulnificus) 		PF06500
(DUF1100) 		3 ALA A  20
ASN A 144
LEU A 145
 None
None
EDO  A 419 ( 3.6A)
 0.45A 5i1nC-3mveA:
undetectable		 5i1nC-3mveA:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzn GLUCARATE
DEHYDRATASE

(Chromohalobacter
salexigens) 		PF13378
(MR_MLE_C) 		3 ALA A 183
ASN A 186
LEU A 187
 None
 0.44A 5i1nC-3mznA:
undetectable		 5i1nC-3mznA:
7.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntv MW1564 PROTEIN

(Staphylococcus
aureus) 		PF01596
(Methyltransf_3) 		3 ALA A 111
ASN A 114
LEU A 115
 None
 0.45A 5i1nC-3ntvA:
undetectable		 5i1nC-3ntvA:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pl5 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
mutans) 		PF02645
(DegV) 		3 ALA A 241
ASN A 244
LEU A 245
 None
 0.50A 5i1nC-3pl5A:
undetectable		 5i1nC-3pl5A:
8.76