SIMILAR PATTERNS OF AMINO ACIDS FOR 5HWA_A_GCSA301_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5l UREASE (ALPHA
SUBUNIT)

(Klebsiella
aerogenes) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		4 ILE C 424
ASP C  77
GLY C 129
THR C 408
 None
 0.83A 5hwaA-1a5lC:
0.4		 5hwaA-1a5lC:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)

(Hepacivirus C) 		PF02907
(Peptidase_S29)
PF07652
(Flavi_DEAD) 		4 ILE A 713
GLY A 141
THR A  46
LEU A 143
 None
 0.80A 5hwaA-1cu1A:
0.0		 5hwaA-1cu1A:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e9y UREASE SUBUNIT ALPHA
UREASE SUBUNIT BETA

(Helicobacter
pylori) 		PF00449
(Urease_alpha)
PF00547
(Urease_gamma)
PF00699
(Urease_beta)
PF01979
(Amidohydro_1) 		4 ILE A 100
GLY A  73
LEU B 565
ASN A  31
 None
 1.06A 5hwaA-1e9yA:
undetectable		 5hwaA-1e9yA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1evj GLUCOSE-FRUCTOSE
OXIDOREDUCTASE

(Zymomonas
mobilis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 ILE A 214
ARG A 200
GLY A 209
ASN A 108
 None
NAD  A 500 (-3.0A)
None
NAD  A 500 (-3.7A)
 0.95A 5hwaA-1evjA:
0.0		 5hwaA-1evjA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h6d PRECURSOR FORM OF
GLUCOSE-FRUCTOSE
OXIDOREDUCTASE

(Zymomonas
mobilis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 ILE A 266
ARG A 252
GLY A 261
ASN A 160
 None
NDP  A 500 ( 2.8A)
None
NDP  A 500 (-3.7A)
 0.94A 5hwaA-1h6dA:
0.0		 5hwaA-1h6dA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h6d PRECURSOR FORM OF
GLUCOSE-FRUCTOSE
OXIDOREDUCTASE

(Zymomonas
mobilis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 ILE A 268
ASP A 404
ARG A 275
LEU A 277
 None
 0.97A 5hwaA-1h6dA:
0.0		 5hwaA-1h6dA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hn0 CHONDROITIN ABC
LYASE I

(Proteus
vulgaris) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF09092
(Lyase_N)
PF09093
(Lyase_catalyt) 		4 GLN A 684
ILE A 790
GLY A 682
LEU A 679
 None
 0.97A 5hwaA-1hn0A:
0.0		 5hwaA-1hn0A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iid PEPTIDE
N-MYRISTOYLTRANSFERA
SE

(Saccharomyces
cerevisiae) 		PF01233
(NMT)
PF02799
(NMT_C) 		4 ARG A 447
GLY A 435
THR A 405
ASN A 449
 None
 0.98A 5hwaA-1iidA:
0.0		 5hwaA-1iidA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ndf CARNITINE
ACETYLTRANSFERASE

(Mus musculus) 		PF00755
(Carn_acyltransf) 		4 ILE A 279
GLY A 249
THR A 252
ASN A 320
 None
 0.93A 5hwaA-1ndfA:
0.0		 5hwaA-1ndfA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nyt SHIKIMATE
5-DEHYDROGENASE

(Escherichia
coli) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		4 ARG A  78
GLY A  98
THR A  76
ASN A  86
 None
None
None
DTV  A1405 (-4.0A)
 1.06A 5hwaA-1nytA:
undetectable		 5hwaA-1nytA:
23.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qgi PROTEIN
(CHITOSANASE)

(Bacillus
circulans) 		PF01374
(Glyco_hydro_46) 		5 ILE A  53
ASP A  55
ARG A  57
GLY A  65
THR A  67
 NAG  A 602 ( 4.7A)
None
GCS  A 600 (-3.7A)
GCS  A 601 ( 4.6A)
None
 0.52A 5hwaA-1qgiA:
39.1		 5hwaA-1qgiA:
99.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w1w STRUCTURAL
MAINTENANCE OF
CHROMOSOME 1

(Saccharomyces
cerevisiae) 		PF02463
(SMC_N) 		4 ILE A1188
ASP A1157
GLY A  38
ASN A  35
 None
MG  A2001 ( 4.1A)
AGS  A2224 (-3.0A)
AGS  A2224 (-3.8A)
 0.96A 5hwaA-1w1wA:
undetectable		 5hwaA-1w1wA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w93 ACETYL-COENZYME A
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 ILE A 110
GLY A  68
THR A 474
ASN A 495
 None
 0.88A 5hwaA-1w93A:
undetectable		 5hwaA-1w93A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3i SIMILAR TO
RAD54-LIKE

(Danio rerio) 		PF00176
(SNF2_N)
PF00271
(Helicase_C) 		4 ILE X 317
ASP X 290
GLY X 182
THR X 184
 None
None
SO4  X 901 ( 3.3A)
SO4  X 902 (-3.9A)
 1.06A 5hwaA-1z3iX:
undetectable		 5hwaA-1z3iX:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cdq ASPARTOKINASE

(Arabidopsis
thaliana) 		PF00696
(AA_kinase) 		4 GLN A 294
ASP A 181
THR A 178
LEU A 235
 None
 1.06A 5hwaA-2cdqA:
undetectable		 5hwaA-2cdqA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f3o PYRUVATE
FORMATE-LYASE 2

(Archaeoglobus
fulgidus) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 GLN A 541
ASP A 424
GLY A 539
THR A 437
 None
 0.83A 5hwaA-2f3oA:
undetectable		 5hwaA-2f3oA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2glx 1,5-ANHYDRO-D-FRUCTO
SE REDUCTASE

(Ensifer
adhaerens) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 ILE A 177
ARG A 163
GLY A 172
ASN A  73
 None
NDP  A1500 (-3.0A)
None
NDP  A1500 (-3.4A)
 1.06A 5hwaA-2glxA:
undetectable		 5hwaA-2glxA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mta METHYLAMINE
DEHYDROGENASE (LIGHT
SUBUNIT)

(Paracoccus
denitrificans) 		PF02975
(Me-amine-dh_L) 		4 ILE L 107
GLY L  33
THR L 122
LEU L  89
 None
None
TRQ  L  57 ( 3.1A)
None
 0.96A 5hwaA-2mtaL:
undetectable		 5hwaA-2mtaL:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpw HYPOTHETICAL
MEMBRANE SPANNING
PROTEIN

(Thermus
thermophilus) 		PF14589
(NrfD_2) 		4 ARG C  47
GLY C 103
THR C  50
LEU C 116
 None
 0.96A 5hwaA-2vpwC:
undetectable		 5hwaA-2vpwC:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zau SELENIDE, WATER
DIKINASE

(Aquifex
aeolicus) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 ASP A  60
GLY A 296
THR A 221
LEU A 298
 None
 1.03A 5hwaA-2zauA:
undetectable		 5hwaA-2zauA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT
C,LINKER,GLUTAMATE--
TRNA LIGASE 2

(Thermotoga
maritima;
synthetic
construct) 		PF00749
(tRNA-synt_1c)
PF02686
(Glu-tRNAGln) 		4 GLN C 550
GLY C 554
THR C 557
LEU C 560
 U  E  35 ( 3.6A)
None
None
None
 0.98A 5hwaA-3al0C:
0.1		 5hwaA-3al0C:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3anv D-SERINE DEHYDRATASE

(Gallus gallus) 		PF01168
(Ala_racemase_N)
PF14031
(D-ser_dehydrat) 		4 ASP A 247
GLY A 241
THR A  46
ASN A  25
 None
PLP  A 401 (-3.4A)
None
None
 1.03A 5hwaA-3anvA:
undetectable		 5hwaA-3anvA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2d CD180 ANTIGEN
LYMPHOCYTE ANTIGEN
86

(Homo sapiens) 		PF00560
(LRR_1)
PF02221
(E1_DerP2_DerF2)
PF13855
(LRR_8) 		4 GLN A 134
ILE C  73
GLY A 110
THR A  85
 None
 0.81A 5hwaA-3b2dA:
undetectable		 5hwaA-3b2dA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bgk PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
mutans) 		PF01256
(Carb_kinase) 		4 ILE A 268
GLY A 221
THR A 218
LEU A  29
 None
 1.03A 5hwaA-3bgkA:
undetectable		 5hwaA-3bgkA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bxz PREPROTEIN
TRANSLOCASE SUBUNIT
SECA

(Escherichia
coli) 		PF07517
(SecA_DEAD) 		4 GLN A 578
GLY A 107
THR A 111
ASN A 415
 None
ADP  A 901 (-3.5A)
None
None
 0.88A 5hwaA-3bxzA:
undetectable		 5hwaA-3bxzA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c75 METHYLAMINE
DEHYDROGENASE LIGHT
CHAIN

(Paracoccus
versutus) 		PF02975
(Me-amine-dh_L) 		4 ILE L 107
GLY L  33
THR L 122
LEU L  89
 None
None
TRQ  L  57 ( 3.4A)
None
 0.92A 5hwaA-3c75L:
undetectable		 5hwaA-3c75L:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ckl SULFOTRANSFERASE
FAMILY CYTOSOLIC 1B
MEMBER 1

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		4 GLY A  93
THR A  91
LEU A  97
ASN A 100
 None
 0.98A 5hwaA-3cklA:
undetectable		 5hwaA-3cklA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dbo UNCHARACTERIZED
PROTEIN

(Mycobacterium
tuberculosis) 		PF01850
(PIN)
PF02604
(PhdYeFM_antitox) 		4 ILE B  70
ASP A  71
GLY B  61
LEU A  81
 None
 1.06A 5hwaA-3dboB:
undetectable		 5hwaA-3dboB:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE

(Mycobacterium
tuberculosis) 		PF00795
(CN_hydrolase)
PF02540
(NAD_synthase) 		4 GLN A 347
ILE A 513
ASP A 372
GLY A 507
 None
 1.06A 5hwaA-3dlaA:
undetectable		 5hwaA-3dlaA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ed5 YFNB

(Bacillus
subtilis) 		PF13419
(HAD_2) 		4 GLN A 100
ASP A  12
GLY A  98
LEU A  24
 None
FMT  A 244 (-3.9A)
None
FMT  A 242 (-4.1A)
 0.97A 5hwaA-3ed5A:
undetectable		 5hwaA-3ed5A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f6t ASPARTATE
AMINOTRANSFERASE

(Lactobacillus
acidophilus) 		PF00155
(Aminotran_1_2) 		5 ILE A 411
ASP A 412
GLY A 405
THR A 402
ASN A 292
 None
 1.25A 5hwaA-3f6tA:
undetectable		 5hwaA-3f6tA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbv PUTATIVE LACI-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Bacteroides
fragilis) 		PF13407
(Peripla_BP_4) 		4 ASP A 163
GLY A 142
THR A 140
ASN A 148
 None
None
EDO  A 362 (-4.2A)
None
 0.96A 5hwaA-3gbvA:
undetectable		 5hwaA-3gbvA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gms PUTATIVE
NADPH:QUINONE
REDUCTASE

(Bacillus
thuringiensis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ASP A  46
GLY A  68
THR A  96
LEU A  89
 None
 0.97A 5hwaA-3gmsA:
undetectable		 5hwaA-3gmsA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4g SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN BF1063

(Bacteroides
fragilis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 GLN A 425
ILE A 423
GLY A 426
ASN A 433
 None
 1.06A 5hwaA-3i4gA:
undetectable		 5hwaA-3i4gA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llx PREDICTED AMINO ACID
ALDOLASE OR RACEMASE

(Idiomarina
loihiensis) 		PF01168
(Ala_racemase_N)
PF14031
(D-ser_dehydrat) 		4 ASP A 241
GLY A 235
THR A  47
ASN A  26
 None
LLP  A  46 ( 3.5A)
LLP  A  46 ( 4.3A)
EDO  A 384 (-4.3A)
 1.04A 5hwaA-3llxA:
undetectable		 5hwaA-3llxA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8q SHIKIMATE
5-DEHYDROGENASE I
ALPHA

(Vibrio cholerae) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		4 ARG B  82
GLY B 102
THR B  80
ASN B  90
 None
 1.03A 5hwaA-3o8qB:
undetectable		 5hwaA-3o8qB:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pc3 CG1753, ISOFORM A

(Drosophila
melanogaster) 		PF00291
(PALP)
PF00571
(CBS) 		4 ILE A 111
GLY A  92
THR A 119
ASN A 194
 None
None
P1T  A 702 (-3.9A)
None
 1.02A 5hwaA-3pc3A:
undetectable		 5hwaA-3pc3A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pv2 DEGQ

(Legionella
fallonii) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		4 ILE A  86
ASP A  83
ARG A  87
LEU A  29
 None
 1.03A 5hwaA-3pv2A:
undetectable		 5hwaA-3pv2A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxn KINESIN-LIKE PROTEIN
NOD

(Drosophila
melanogaster) 		PF00225
(Kinesin) 		4 GLY A 252
THR A 278
LEU A 254
ASN A 257
 None
 1.05A 5hwaA-3pxnA:
undetectable		 5hwaA-3pxnA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qxz ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus) 		PF00378
(ECH_1) 		4 ILE A 108
GLY A  32
THR A  28
LEU A   5
 EDO  A 264 (-4.7A)
None
None
None
 0.98A 5hwaA-3qxzA:
undetectable		 5hwaA-3qxzA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rc2 SUGAR
3-KETOREDUCTASE

(Actinomadura
kijaniata) 		PF01408
(GFO_IDH_MocA) 		4 ILE A  10
ARG A  11
GLY A  13
THR A  38
 None
 0.93A 5hwaA-3rc2A:
undetectable		 5hwaA-3rc2A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3smt HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3

(Homo sapiens) 		PF00856
(SET)
PF09273
(Rubis-subs-bind) 		4 GLN A 300
ILE A 308
GLY A 281
THR A 279
 None
 0.97A 5hwaA-3smtA:
0.2		 5hwaA-3smtA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9h ACRIFLAVINE
RESISTANCE PROTEIN B

(Escherichia
coli) 		PF00873
(ACR_tran) 		4 GLN A 577
ASP A  83
GLY A 616
ASN A 623
 None
 0.88A 5hwaA-3w9hA:
1.6		 5hwaA-3w9hA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0s OCTENOYL-COA
REDUCTASE/CARBOXYLAS
E

(Streptomyces
cinnabarigriseus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLN A  99
ARG A 105
GLY A 100
ASN A  96
 None
 1.02A 5hwaA-4a0sA:
undetectable		 5hwaA-4a0sA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cn8 PROXIMAL THREAD
MATRIX PROTEIN 1

(Mytilus
galloprovincialis) 		PF00092
(VWA) 		4 ILE A 264
ASP A 369
GLY A 333
THR A 335
 None
 1.03A 5hwaA-4cn8A:
undetectable		 5hwaA-4cn8A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4evf GIARDIN SUBUNIT
ALPHA-1

(Giardia
intestinalis) 		PF00191
(Annexin) 		4 ILE A 276
ARG A 278
GLY A 243
ASN A 240
 None
 1.00A 5hwaA-4evfA:
undetectable		 5hwaA-4evfA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f1k THROMBOSPONDIN
RELATED ANONYMOUS
PROTEIN

(Plasmodium
falciparum) 		PF00092
(VWA) 		4 ILE A  59
ASP A 162
GLY A 129
THR A 131
 None
 1.06A 5hwaA-4f1kA:
undetectable		 5hwaA-4f1kA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1h SORTASE FAMILY
PROTEIN

(Streptococcus
agalactiae) 		PF04203
(Sortase) 		4 GLN A 106
ASP A 118
GLY A 108
THR A 180
 None
 0.89A 5hwaA-4g1hA:
undetectable		 5hwaA-4g1hA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gtr PROTEIN
FARNESYLTRANSFERASE/
GERANYLGERANYLTRANSF
ERASE TYPE-1 SUBUNIT
ALPHA

(Rattus
norvegicus) 		PF01239
(PPTA) 		4 GLN A 364
ARG A 357
GLY A 360
LEU A 338
 None
 1.02A 5hwaA-4gtrA:
undetectable		 5hwaA-4gtrA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i99 CHROMOSOME PARTITION
PROTEIN SMC

(Pyrococcus
furiosus) 		PF02463
(SMC_N) 		4 ILE A1127
ASP A1097
GLY A  38
ASN A  35
 None
None
PO4  A1202 (-3.3A)
None
 1.04A 5hwaA-4i99A:
undetectable		 5hwaA-4i99A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iug BETA-GALACTOSIDASE A

(Aspergillus
oryzae) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 GLY A 818
THR A 747
LEU A 728
ASN A 799
 None
 1.04A 5hwaA-4iugA:
undetectable		 5hwaA-4iugA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jd0 NUCLEOTIDYL
TRANSFERASE

(Thermotoga
maritima) 		PF00483
(NTP_transferase) 		4 ASP A 219
GLY A 168
LEU A 191
ASN A  85
 NA  A 315 (-3.5A)
1KH  A 301 (-3.4A)
1KH  A 301 (-4.3A)
GOL  A 314 ( 2.9A)
 0.79A 5hwaA-4jd0A:
undetectable		 5hwaA-4jd0A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Mus musculus) 		PF00069
(Pkinase) 		4 ILE A 114
ARG A 143
LEU A  98
ASN A 103
 None
 1.04A 5hwaA-4jlcA:
undetectable		 5hwaA-4jlcA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kc5 RHIE PROTEIN

(Paraburkholderia
rhizoxinica) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 GLY A3403
THR A3290
LEU A3405
ASN A3256
 None
 1.00A 5hwaA-4kc5A:
undetectable		 5hwaA-4kc5A:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l4i RYANODINE RECEPTOR 2

(Mus musculus) 		PF01365
(RYDR_ITPR)
PF02815
(MIR)
PF08709
(Ins145_P3_rec) 		4 GLN A 225
ILE A 229
ASP A 232
GLY A 226
 None
 1.01A 5hwaA-4l4iA:
undetectable		 5hwaA-4l4iA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLN A 170
ILE A 143
ASP A 203
GLY A 166
 None
 0.98A 5hwaA-4lg4A:
undetectable		 5hwaA-4lg4A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lsb LYASE/MUTASE

(Burkholderia
cenocepacia) 		PF13714
(PEP_mutase) 		4 ILE A  26
GLY A 114
THR A 154
LEU A  88
 None
 0.92A 5hwaA-4lsbA:
undetectable		 5hwaA-4lsbA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9x TCDB2, TCCC3

(Photorhabdus
luminescens) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		4 ILE A1241
ASP A1235
ARG A1239
GLY A  51
 None
 1.05A 5hwaA-4o9xA:
undetectable		 5hwaA-4o9xA:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9x TCDB2, TCCC3

(Photorhabdus
luminescens) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		4 ILE A1241
ASP A1235
ARG A1239
GLY A  52
 None
 1.01A 5hwaA-4o9xA:
undetectable		 5hwaA-4o9xA:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4omu SHIKIMATE
DEHYDROGENASE

(Pseudomonas
putida) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		4 ARG A  77
GLY A  97
THR A  75
ASN A  85
 None
 1.03A 5hwaA-4omuA:
undetectable		 5hwaA-4omuA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q5r GLUTATHIONE
S-TRANSFERASE

(Blattella
germanica) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 ILE A  89
ASP A  90
ARG A  70
GLY A  73
 None
 0.78A 5hwaA-4q5rA:
undetectable		 5hwaA-4q5rA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qmh LP04448P

(Drosophila
melanogaster) 		PF12348
(CLASP_N) 		4 ILE A 916
GLY A 880
THR A 876
LEU A 865
 None
 1.03A 5hwaA-4qmhA:
undetectable		 5hwaA-4qmhA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qwp CHITOSANASE

(Pseudomonas sp.
A-01) 		PF01374
(Glyco_hydro_46) 		4 ILE A  41
ARG A  45
GLY A  53
THR A  55
 GCS  A 303 (-4.2A)
GCS  A 302 (-4.0A)
None
GCS  A 302 ( 4.2A)
 0.20A 5hwaA-4qwpA:
10.7		 5hwaA-4qwpA:
26.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6h SOLUTE BINDING
PROTEIN MSME

(Bacillus
subtilis) 		PF01547
(SBP_bac_1) 		4 GLN A 119
GLY A 327
LEU A 101
ASN A 100
 None
 0.81A 5hwaA-4r6hA:
undetectable		 5hwaA-4r6hA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1

(Homo sapiens;
synthetic
construct) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 GLN A3759
ASP A1720
GLY A3758
LEU A3762
 None
 1.04A 5hwaA-4rh7A:
undetectable		 5hwaA-4rh7A:
5.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rn7 N-ACETYLMURAMOYL-L-A
LANINE AMIDASE

(Clostridioides
difficile) 		PF01520
(Amidase_3) 		4 ILE A 258
GLY A 290
THR A 226
LEU A 292
 None
None
None
GOL  A 402 ( 4.5A)
 0.83A 5hwaA-4rn7A:
undetectable		 5hwaA-4rn7A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rzl RESTRICTION
ENDONUCLEASE LPNPI

(Legionella
pneumophila) 		no annotation 4 ILE A  16
ASP A  17
GLY A  78
THR A  75
 None
 0.93A 5hwaA-4rzlA:
undetectable		 5hwaA-4rzlA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tx1 ESTERASE

(Sinorhizobium
meliloti) 		PF13472
(Lipase_GDSL_2) 		4 ILE A  96
ASP A  91
GLY A  50
LEU A  48
 None
 1.03A 5hwaA-4tx1A:
undetectable		 5hwaA-4tx1A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z3y BENZOYL-COA
REDUCTASE, PUTATIVE

(Geobacter
metallireducens) 		PF01314
(AFOR_C)
PF02730
(AFOR_N) 		4 ILE A 649
ARG A 585
GLY A 587
LEU A  89
 None
 1.07A 5hwaA-4z3yA:
undetectable		 5hwaA-4z3yA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z6g MICROTUBULE-ACTIN
CROSS-LINKING FACTOR
1, ISOFORMS 1/2/3/5

(Homo sapiens) 		PF00307
(CH) 		4 GLY A 138
THR A 142
LEU A 135
ASN A 122
 None
 0.86A 5hwaA-4z6gA:
undetectable		 5hwaA-4z6gA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a05 ALDOSE-ALDOSE
OXIDOREDUCTASE

(Caulobacter
vibrioides) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 ILE A 186
ARG A 172
GLY A 181
ASN A  83
 None
NDP  A1340 (-2.8A)
None
NDP  A1340 (-3.9A)
 0.89A 5hwaA-5a05A:
undetectable		 5hwaA-5a05A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aey PLASMID SEGREGATION
PROTEIN PARM

(Escherichia
coli) 		PF06406
(StbA) 		4 GLN A 308
ILE A 227
GLY A 281
ASN A  11
 ANP  A 500 (-2.6A)
ANP  A 500 (-4.0A)
ANP  A 500 (-3.6A)
ANP  A 500 (-4.3A)
 1.04A 5hwaA-5aeyA:
undetectable		 5hwaA-5aeyA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cer BD0816

(Bdellovibrio
bacteriovorus) 		PF02113
(Peptidase_S13) 		4 ARG A 144
GLY A 105
LEU A 135
ASN A 165
 None
 1.02A 5hwaA-5cerA:
undetectable		 5hwaA-5cerA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dac PUTATIVE
UNCHARACTERIZED
PROTEIN,PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF13476
(AAA_23) 		4 ILE A1273
ASP A1237
GLY A  39
ASN A  36
 None
MG  A1401 ( 3.7A)
AGS  A1402 (-3.1A)
AGS  A1402 (-3.7A)
 0.98A 5hwaA-5dacA:
undetectable		 5hwaA-5dacA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dl5 MEMBRANE PROTEIN

(Acinetobacter
baumannii) 		PF03573
(OprD) 		4 GLN A 293
ILE A 312
ASP A 310
GLY A 292
 None
 1.05A 5hwaA-5dl5A:
undetectable		 5hwaA-5dl5A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fse UREASE SUBUNIT ALPHA

(Sporosarcina
pasteurii) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		4 ILE C 427
ASP C  78
GLY C 132
THR C 411
 None
 0.96A 5hwaA-5fseC:
undetectable		 5hwaA-5fseC:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h2v IMPORTIN SUBUNIT
BETA-3

(Saccharomyces
cerevisiae) 		PF13513
(HEAT_EZ) 		4 ILE A 916
ASP A 913
ARG A 915
LEU A 835
 None
 1.03A 5hwaA-5h2vA:
undetectable		 5hwaA-5h2vA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h5l GLUTATHIONE
S-TRANSFERASE S2

(Nilaparvata
lugens) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 ILE A  88
ASP A  89
ARG A  69
GLY A  72
 None
 0.70A 5hwaA-5h5lA:
undetectable		 5hwaA-5h5lA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hcf CALRETICULIN,
PUTATIVE,CALRETICULI
N, PUTATIVE

(Trypanosoma
cruzi) 		PF00262
(Calreticulin) 		4 GLN A 321
ILE A 317
GLY A 107
LEU A 103
 None
None
ACY  A 402 ( 4.9A)
None
 0.94A 5hwaA-5hcfA:
undetectable		 5hwaA-5hcfA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jta NEUTRAL TREHALASE

(Saccharomyces
cerevisiae) 		no annotation 4 ILE A 215
ASP A 212
ARG A 349
LEU A 353
 None
 1.04A 5hwaA-5jtaA:
undetectable		 5hwaA-5jtaA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli) 		PF01043
(SecA_PP_bind)
PF07517
(SecA_DEAD) 		4 GLN A 578
GLY A 107
THR A 111
ASN A 415
 None
ADP  A 901 (-3.0A)
None
None
 0.99A 5hwaA-5k9tA:
undetectable		 5hwaA-5k9tA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ksd ATPASE 2, PLASMA
MEMBRANE-TYPE

(Arabidopsis
thaliana) 		PF00122
(E1-E2_ATPase)
PF00690
(Cation_ATPase_N)
PF00702
(Hydrolase) 		4 ILE A 374
ASP A 375
GLY A 424
THR A 407
 ACP  A 904 (-4.3A)
ACP  A 904 (-3.4A)
ACP  A 904 ( 3.8A)
ACP  A 904 (-3.6A)
 1.02A 5hwaA-5ksdA:
undetectable		 5hwaA-5ksdA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lew DNA POLYMERASE III
SUBUNIT ALPHA

(Mycobacterium
tuberculosis) 		no annotation 4 GLN A 164
ASP A 226
GLY A 157
THR A 109
 None
ZN  A1002 (-2.5A)
None
None
 0.98A 5hwaA-5lewA:
undetectable		 5hwaA-5lewA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lki TCDA1

(Photorhabdus
luminescens) 		PF03538
(VRP1) 		4 ILE A2475
GLY A2436
THR A2481
LEU A1983
 None
 1.04A 5hwaA-5lkiA:
1.3		 5hwaA-5lkiA:
7.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqc VP1

(Black queen
cell virus) 		PF08762
(CRPV_capsid) 		4 ILE A  74
ARG A  54
GLY A 215
THR A 104
 None
 1.06A 5hwaA-5mqcA:
undetectable		 5hwaA-5mqcA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n1t FLAVIN-BINDING
SUBUNIT OF SULFIDE
DEHYDROGENASE

(Thioalkalivibrio
paradoxus) 		no annotation 4 ILE A 288
ARG A 290
GLY A 293
THR A 295
 FAD  A 501 (-3.3A)
None
None
None
 0.84A 5hwaA-5n1tA:
undetectable		 5hwaA-5n1tA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nop ATTACHMENT
GLYCOPROTEIN

(Mojiang
henipavirus) 		PF00423
(HN) 		4 GLN A 512
ARG A 463
GLY A 510
THR A 508
 None
 0.80A 5hwaA-5nopA:
undetectable		 5hwaA-5nopA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udb CELL DIVISION CYCLE
PROTEIN CDT1

(Saccharomyces
cerevisiae) 		PF16679
(CDT1_C) 		4 GLN 8 543
ILE 8 557
THR 8 514
ASN 8 547
 None
 0.97A 5hwaA-5udb8:
undetectable		 5hwaA-5udb8:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9r CITRATE-SODIUM
SYMPORTER

(Klebsiella
pneumoniae) 		PF03390
(2HCT) 		4 ASP A 407
GLY A 185
LEU A 216
ASN A 220
 None
FLC  A 501 (-3.5A)
None
None
 0.76A 5hwaA-5x9rA:
undetectable		 5hwaA-5x9rA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xei CHROMOSOME PARTITION
PROTEIN SMC

(Pyrococcus
yayanosii) 		PF02463
(SMC_N) 		4 ILE A1127
ASP A1097
GLY A  38
ASN A  35
 None
 1.06A 5hwaA-5xeiA:
undetectable		 5hwaA-5xeiA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Komagataella
phaffii) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		4 GLN B1093
ILE B 756
GLY B 774
LEU B1095
 None
 1.00A 5hwaA-5xogB:
undetectable		 5hwaA-5xogB:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
RNA POLYMERASE
SUBUNIT ABC10-ALPHA

(Komagataella
phaffii) 		PF00562
(RNA_pol_Rpb2_6)
PF03604
(DNA_RNApol_7kD)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		4 ILE B 899
ARG L  65
GLY B 902
THR L  63
 None
 1.01A 5hwaA-5xogB:
undetectable		 5hwaA-5xogB:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xuy AUTOPHAGY-RELATED
PROTEIN 13

(Homo sapiens) 		no annotation 4 ILE A  17
ASP A  14
ARG A  10
GLY A 181
 None
 1.02A 5hwaA-5xuyA:
undetectable		 5hwaA-5xuyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z9y THIAZOLE SYNTHASE

(Mycobacterium
tuberculosis) 		no annotation 4 ILE A  66
GLY A  20
THR A  43
LEU A 206
 None
DXP  A 301 ( 3.8A)
DXP  A 301 (-3.3A)
DXP  A 301 (-4.7A)
 1.04A 5hwaA-5z9yA:
undetectable		 5hwaA-5z9yA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zib -

(-) 		no annotation 4 GLN A 614
GLY A 611
THR A 608
LEU A 256
 None
 0.80A 5hwaA-5zibA:
undetectable		 5hwaA-5zibA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zic -

(-) 		no annotation 4 GLN A 614
GLY A 611
THR A 608
LEU A 256
 None
 0.91A 5hwaA-5zicA:
undetectable		 5hwaA-5zicA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ztp CARBONIC ANHYDRASE

(Glaciozyma
antarctica) 		no annotation 4 ILE A 134
ASP A 131
ARG A 157
THR A  91
 None
 1.06A 5hwaA-5ztpA:
undetectable		 5hwaA-5ztpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b0k IOTA-CARRAGEENAN
SULFATASE

(Pseudoalteromonas) 		no annotation 4 ILE A  53
ASP A  52
GLY A 299
LEU A 296
 None
 1.03A 5hwaA-6b0kA:
undetectable		 5hwaA-6b0kA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bqy TYROSINE--TRNA
LIGASE

(Acinetobacter
baumannii) 		no annotation 4 GLN A 200
ASP A 159
LEU A 204
ASN A 203
 None
 0.88A 5hwaA-6bqyA:
undetectable		 5hwaA-6bqyA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eot DIPEPTIDYL PEPTIDASE
8

(Homo sapiens) 		no annotation 4 ASP A 745
ARG A 748
GLY A 750
LEU A 884
 None
 0.98A 5hwaA-6eotA:
undetectable		 5hwaA-6eotA:
15.08