SIMILAR PATTERNS OF AMINO ACIDS FOR 5HW8_H_FK5H201

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e4o MALTODEXTRIN
PHOSPHORYLASE

(Escherichia
coli) 		PF00343
(Phosphorylase) 		4 TYR A  63
PHE A 122
ILE A 791
TRP A 792
 None
 0.95A 5hw8H-1e4oA:
undetectable		 5hw8H-1e4oA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ee0 2-PYRONE SYNTHASE

(Gerbera hybrid
cultivar) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 ASP A 352
VAL A 194
ILE A 193
ILE A 241
 None
 0.93A 5hw8H-1ee0A:
undetectable		 5hw8H-1ee0A:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f20 NITRIC-OXIDE
SYNTHASE

(Rattus
norvegicus) 		PF00175
(NAD_binding_1)
PF00667
(FAD_binding_1) 		4 TYR A1175
VAL A1195
ILE A1194
ILE A1218
 FAD  A1501 (-4.3A)
NAP  A1502 ( 4.5A)
None
None
 0.73A 5hw8H-1f20A:
undetectable		 5hw8H-1f20A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila) 		PF00254
(FKBP_C)
PF01346
(FKBP_N) 		6 TYR A 131
ASP A 142
VAL A 158
ILE A 159
TRP A 162
PHE A 202
 None
 0.77A 5hw8H-1fd9A:
13.0		 5hw8H-1fd9A:
23.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fkk FK506 BINDING
PROTEIN

(Bos taurus) 		PF00254
(FKBP_C) 		8 TYR A  26
ASP A  37
PHE A  46
VAL A  55
ILE A  56
TRP A  59
ILE A  90
PHE A  99
 None
 0.66A 5hw8H-1fkkA:
15.7		 5hw8H-1fkkA:
45.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h0p PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
5

(Caenorhabditis
elegans) 		PF00160
(Pro_isomerase) 		4 VAL A  30
ILE A  46
ILE A 166
PHE A 136
 None
 0.75A 5hw8H-1h0pA:
undetectable		 5hw8H-1h0pA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i4s RIBONUCLEASE III

(Aquifex
aeolicus) 		PF14622
(Ribonucleas_3_3) 		4 ASP A 138
VAL A  47
ILE A  51
PHE A  79
 None
 0.88A 5hw8H-1i4sA:
undetectable		 5hw8H-1i4sA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ibv HISTIDINE
DECARBOXYLASE ALPHA
CHAIN

(Lactobacillus
sp. 30A) 		PF02329
(HDC) 		4 PHE B 195
VAL B  90
ILE B  91
ILE B 150
 None
 0.98A 5hw8H-1ibvB:
undetectable		 5hw8H-1ibvB:
20.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR

(Trypanosoma
cruzi) 		PF00254
(FKBP_C) 		4 TYR A  92
ASP A 103
TRP A 123
PHE A 163
 None
 0.77A 5hw8H-1jvwA:
12.2		 5hw8H-1jvwA:
32.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR

(Trypanosoma
cruzi) 		PF00254
(FKBP_C) 		5 TYR A  92
VAL A 119
ILE A 120
TRP A 123
PHE A 163
 None
 0.71A 5hw8H-1jvwA:
12.2		 5hw8H-1jvwA:
32.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kt1 FK506-BINDING
PROTEIN FKBP51

(Saimiri
boliviensis) 		PF00254
(FKBP_C)
PF00515
(TPR_1)
PF13181
(TPR_8) 		4 PHE A  77
ILE A  87
TRP A  90
PHE A 130
 None
 0.92A 5hw8H-1kt1A:
11.6		 5hw8H-1kt1A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kt1 FK506-BINDING
PROTEIN FKBP51

(Saimiri
boliviensis) 		PF00254
(FKBP_C)
PF00515
(TPR_1)
PF13181
(TPR_8) 		4 PHE A  77
VAL A  86
TRP A  90
PHE A 130
 None
 0.83A 5hw8H-1kt1A:
11.6		 5hw8H-1kt1A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kt1 FK506-BINDING
PROTEIN FKBP51

(Saimiri
boliviensis) 		PF00254
(FKBP_C)
PF00515
(TPR_1)
PF13181
(TPR_8) 		4 TYR A  57
PHE A  77
VAL A  86
TRP A  90
 None
 0.54A 5hw8H-1kt1A:
11.6		 5hw8H-1kt1A:
18.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1n1a FKBP52

(Homo sapiens) 		PF00254
(FKBP_C) 		5 ASP A  68
PHE A  77
VAL A  86
ILE A  87
TRP A  90
 None
 0.55A 5hw8H-1n1aA:
13.5		 5hw8H-1n1aA:
36.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1n1a FKBP52

(Homo sapiens) 		PF00254
(FKBP_C) 		6 TYR A  57
ASP A  68
PHE A  77
VAL A  86
TRP A  90
PHE A 130
 None
 0.59A 5hw8H-1n1aA:
13.5		 5hw8H-1n1aA:
36.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oc2 DTDP-GLUCOSE
4,6-DEHYDRATASE

(Streptococcus
suis) 		PF16363
(GDP_Man_Dehyd) 		4 TYR A  82
PHE A  20
ILE A 240
ILE A 228
 None
 0.96A 5hw8H-1oc2A:
undetectable		 5hw8H-1oc2A:
16.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pbk FKBP25

(Homo sapiens) 		PF00254
(FKBP_C) 		6 TYR A 135
ASP A 146
VAL A 171
ILE A 172
TRP A 175
PHE A 216
 RAP  A 225 (-3.9A)
RAP  A 225 (-3.0A)
RAP  A 225 (-3.5A)
RAP  A 225 (-3.9A)
RAP  A 225 (-3.4A)
None
 0.53A 5hw8H-1pbkA:
14.8		 5hw8H-1pbkA:
40.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q6h FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA

(Escherichia
coli) 		PF00254
(FKBP_C)
PF01346
(FKBP_N) 		5 TYR A 146
ASP A 157
VAL A 173
ILE A 174
PHE A 216
 None
 0.46A 5hw8H-1q6hA:
13.1		 5hw8H-1q6hA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q6h FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA

(Escherichia
coli) 		PF00254
(FKBP_C)
PF01346
(FKBP_N) 		5 TYR A 146
VAL A 173
ILE A 174
TRP A 177
PHE A 216
 None
 0.57A 5hw8H-1q6hA:
13.1		 5hw8H-1q6hA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qdn PROTEIN
(N-ETHYLMALEIMIDE
SENSITIVE FUSION
PROTEIN (NSF))

(Cricetulus
griseus) 		PF02359
(CDC48_N)
PF02933
(CDC48_2) 		4 PHE A  85
VAL A 174
ILE A 152
ILE A 122
 None
 0.91A 5hw8H-1qdnA:
undetectable		 5hw8H-1qdnA:
20.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1r9h FK506 BINDING
PROTEIN FAMILY

(Caenorhabditis
elegans) 		PF00254
(FKBP_C) 		6 TYR A  40
ASP A  51
PHE A  60
ILE A  70
TRP A  73
PHE A 113
 None
 0.72A 5hw8H-1r9hA:
15.0		 5hw8H-1r9hA:
34.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1r9h FK506 BINDING
PROTEIN FAMILY

(Caenorhabditis
elegans) 		PF00254
(FKBP_C) 		6 TYR A  40
PHE A  60
VAL A  69
ILE A  70
TRP A  73
PHE A 113
 None
 0.64A 5hw8H-1r9hA:
15.0		 5hw8H-1r9hA:
34.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rc7 RIBONUCLEASE III

(Aquifex
aeolicus) 		PF00035
(dsrm)
PF14622
(Ribonucleas_3_3) 		4 ASP A 138
VAL A  47
ILE A  51
PHE A  79
 None
 0.79A 5hw8H-1rc7A:
undetectable		 5hw8H-1rc7A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sfs HYPOTHETICAL PROTEIN

(Geobacillus
stearothermophilus) 		PF08924
(DUF1906) 		4 ASP A   9
VAL A  59
ILE A  54
ILE A  64
 None
 0.94A 5hw8H-1sfsA:
undetectable		 5hw8H-1sfsA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tll NITRIC-OXIDE
SYNTHASE, BRAIN

(Rattus
norvegicus) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		4 TYR A1175
VAL A1195
ILE A1194
ILE A1218
 FAD  A1452 (-4.4A)
NAP  A1453 (-3.6A)
None
None
 0.79A 5hw8H-1tllA:
undetectable		 5hw8H-1tllA:
11.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u79 FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
3

(Arabidopsis
thaliana) 		PF00254
(FKBP_C) 		6 TYR A  37
ASP A  48
VAL A  66
ILE A  67
TRP A  70
PHE A 121
 None
 0.65A 5hw8H-1u79A:
14.7		 5hw8H-1u79A:
40.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w2u ENDOGLUCANASE

(Humicola grisea) 		PF01670
(Glyco_hydro_12) 		4 TYR A 190
ILE A  80
ILE A 198
PHE A 181
 None
 0.98A 5hw8H-1w2uA:
undetectable		 5hw8H-1w2uA:
21.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1yat FK506 BINDING
PROTEIN

(Saccharomyces
cerevisiae) 		PF00254
(FKBP_C) 		7 TYR A  26
ASP A  37
PHE A  46
VAL A  55
ILE A  56
TRP A  59
PHE A  99
 FK5  A 108 ( 4.0A)
FK5  A 108 ( 3.3A)
FK5  A 108 ( 4.0A)
FK5  A 108 ( 3.4A)
FK5  A 108 ( 3.7A)
FK5  A 108 ( 3.6A)
None
 0.60A 5hw8H-1yatA:
15.9		 5hw8H-1yatA:
55.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygp YEAST GLYCOGEN
PHOSPHORYLASE

(Saccharomyces
cerevisiae) 		PF00343
(Phosphorylase) 		4 TYR A  84
PHE A 143
ILE A 824
TRP A 825
 None
 0.91A 5hw8H-1ygpA:
undetectable		 5hw8H-1ygpA:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yp1 FII

(Deinagkistrodon
acutus) 		PF01421
(Reprolysin) 		4 TYR A  22
ASP A 128
ILE A  56
ILE A 126
 None
 0.82A 5hw8H-1yp1A:
undetectable		 5hw8H-1yp1A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buc DIPEPTIDYL PEPTIDASE
IV

(Sus scrofa) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 TYR A 118
ASP A 133
ILE A 155
ILE A 143
 None
 0.84A 5hw8H-2bucA:
undetectable		 5hw8H-2bucA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4m GLYCOGEN
PHOSPHORYLASE

(Corynebacterium
callunae) 		PF00343
(Phosphorylase) 		4 TYR A  63
PHE A 122
ILE A 784
TRP A 785
 None
 0.89A 5hw8H-2c4mA:
undetectable		 5hw8H-2c4mA:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fbv WERNER SYNDROME
HELICASE

(Homo sapiens) 		PF01612
(DNA_pol_A_exo1) 		4 ASP A  82
VAL A 181
ILE A 223
ILE A 140
 MN  A 238 ( 2.8A)
None
None
None
 0.96A 5hw8H-2fbvA:
undetectable		 5hw8H-2fbvA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hcz BETA-EXPANSIN 1A

(Zea mays) 		PF01357
(Pollen_allerg_1)
PF03330
(DPBB_1) 		4 VAL X 175
ILE X 174
ILE X 223
PHE X 244
 None
 0.69A 5hw8H-2hczX:
undetectable		 5hw8H-2hczX:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nul PEPTIDYLPROLYL
ISOMERASE

(Escherichia
coli) 		PF00160
(Pro_isomerase) 		4 VAL A   2
ILE A  13
ILE A 136
PHE A  98
 None
 0.84A 5hw8H-2nulA:
undetectable		 5hw8H-2nulA:
22.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2pbc FK506-BINDING
PROTEIN 2

(Homo sapiens) 		PF00254
(FKBP_C) 		7 TYR A  56
ASP A  67
PHE A  76
VAL A  85
ILE A  86
TRP A  89
PHE A 129
 PEG  A 201 (-4.4A)
None
PEG  A 201 ( 3.9A)
PEG  A 201 (-3.6A)
PEG  A 201 (-3.8A)
PEG  A 201 (-3.7A)
None
 0.68A 5hw8H-2pbcA:
13.6		 5hw8H-2pbcA:
44.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rmc PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
C

(Mus musculus) 		PF00160
(Pro_isomerase) 		4 VAL A  40
ILE A  56
ILE A 176
PHE A 146
 None
 0.77A 5hw8H-2rmcA:
undetectable		 5hw8H-2rmcA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v91 STRICTOSIDINE
SYNTHASE

(Rauvolfia
serpentina) 		PF03088
(Str_synth) 		4 TYR A  56
ASP A  49
PHE A  77
VAL A 128
 None
 0.94A 5hw8H-2v91A:
undetectable		 5hw8H-2v91A:
19.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vcd OUTER MEMBRANE
PROTEIN MIP

(Legionella
pneumophila) 		PF00254
(FKBP_C)
PF01346
(FKBP_N) 		5 TYR A  55
ASP A  66
VAL A  82
ILE A  83
TRP A  86
 RAP  A 138 (-2.6A)
RAP  A 138 (-2.7A)
RAP  A 138 (-3.2A)
RAP  A 138 (-3.6A)
RAP  A 138 (-2.3A)
 0.75A 5hw8H-2vcdA:
11.5		 5hw8H-2vcdA:
34.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vn1 70 KDA
PEPTIDYLPROLYL
ISOMERASE

(Plasmodium
falciparum) 		PF00254
(FKBP_C) 		7 TYR A  44
ASP A  56
PHE A  65
VAL A  74
ILE A  75
TRP A  78
PHE A 118
 FK5  A 501 (-4.1A)
FK5  A 501 (-3.4A)
FK5  A 501 (-4.1A)
FK5  A 501 (-3.5A)
FK5  A 501 (-4.3A)
FK5  A 501 (-3.3A)
FK5  A 501 (-4.8A)
 0.58A 5hw8H-2vn1A:
14.5		 5hw8H-2vn1A:
33.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT

(Methanosarcina
mazei) 		PF07521
(RMMBL)
PF07650
(KH_2)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		4 ILE A 128
TRP A 130
ILE A  91
PHE A  96
 None
 0.93A 5hw8H-2xr1A:
undetectable		 5hw8H-2xr1A:
11.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2y78 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Burkholderia
pseudomallei) 		PF00254
(FKBP_C) 		5 TYR A  33
ASP A  44
PHE A  53
TRP A  66
PHE A 106
 None
 0.70A 5hw8H-2y78A:
14.5		 5hw8H-2y78A:
47.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2y78 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Burkholderia
pseudomallei) 		PF00254
(FKBP_C) 		6 TYR A  33
PHE A  53
VAL A  62
ILE A  63
TRP A  66
PHE A 106
 None
 0.66A 5hw8H-2y78A:
14.5		 5hw8H-2y78A:
47.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cem GLYCOGEN
PHOSPHORYLASE, LIVER
FORM

(Homo sapiens) 		PF00343
(Phosphorylase) 		4 TYR A  84
PHE A 143
ILE A 824
TRP A 825
 None
 0.89A 5hw8H-3cemA:
undetectable		 5hw8H-3cemA:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7x FEMALE-SPECIFIC
HISTAMINE-BINDING
PROTEIN 2

(Rhipicephalus
appendiculatus) 		PF02098
(His_binding) 		4 ASP A  39
PHE A  67
ILE A 122
TRP A 137
 HSM  A 174 (-2.8A)
None
None
None
 0.99A 5hw8H-3g7xA:
undetectable		 5hw8H-3g7xA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5q NUCLEOPORIN NUP170

(Saccharomyces
cerevisiae) 		no annotation 4 PHE B1308
VAL B1335
ILE B1336
ILE B1374
 None
 0.79A 5hw8H-3i5qB:
undetectable		 5hw8H-3i5qB:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lhl PUTATIVE AGMATINASE

(Clostridioides
difficile) 		PF00491
(Arginase) 		4 TYR A 211
ASP A 258
ILE A  97
ILE A 107
 None
 0.99A 5hw8H-3lhlA:
undetectable		 5hw8H-3lhlA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n5f N-CARBAMOYL-L-AMINO
ACID HYDROLASE

(Geobacillus
stearothermophilus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 VAL A 247
ILE A 248
ILE A 213
PHE A 217
 None
 0.84A 5hw8H-3n5fA:
undetectable		 5hw8H-3n5fA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o5d PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5

(Homo sapiens) 		PF00254
(FKBP_C) 		6 TYR A  57
ASP A  68
PHE A  77
ILE A  87
TRP A  90
PHE A 130
 None
 0.90A 5hw8H-3o5dA:
14.2		 5hw8H-3o5dA:
27.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o5d PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5

(Homo sapiens) 		PF00254
(FKBP_C) 		6 TYR A  57
PHE A  77
VAL A  86
ILE A  87
TRP A  90
PHE A 130
 None
 0.83A 5hw8H-3o5dA:
14.2		 5hw8H-3o5dA:
27.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o5e PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5

(Homo sapiens) 		PF00254
(FKBP_C) 		4 PHE A  77
VAL A  86
ILE A  87
TRP A  90
 None
 0.71A 5hw8H-3o5eA:
14.1		 5hw8H-3o5eA:
39.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o5e PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5

(Homo sapiens) 		PF00254
(FKBP_C) 		4 TYR A  57
ASP A  68
PHE A  77
ILE A  87
 None
 0.68A 5hw8H-3o5eA:
14.1		 5hw8H-3o5eA:
39.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o5e PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5

(Homo sapiens) 		PF00254
(FKBP_C) 		4 TYR A  57
PHE A  77
ILE A  87
TRP A  90
 None
 0.76A 5hw8H-3o5eA:
14.1		 5hw8H-3o5eA:
39.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pa7 70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE

(Plasmodium
vivax) 		PF00254
(FKBP_C) 		6 TYR A  43
ASP A  55
PHE A  64
VAL A  73
TRP A  77
PHE A 117
 None
 0.68A 5hw8H-3pa7A:
14.3		 5hw8H-3pa7A:
36.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pa7 70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE

(Plasmodium
vivax) 		PF00254
(FKBP_C) 		6 TYR A  43
PHE A  64
VAL A  73
ILE A  74
TRP A  77
PHE A 117
 None
 0.65A 5hw8H-3pa7A:
14.3		 5hw8H-3pa7A:
36.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u8p CYTOCHROME B562
INTEGRAL FUSION WITH
ENHANCED GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Escherichia
coli) 		PF01353
(GFP)
PF07361
(Cytochrom_B562) 		4 TYR A 200
PHE A 192
VAL A 271
ILE A 231
 None
 0.94A 5hw8H-3u8pA:
undetectable		 5hw8H-3u8pA:
15.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bf8 FPR4

(Saccharomyces
cerevisiae) 		PF00254
(FKBP_C) 		5 TYR A 313
ASP A 324
PHE A 332
TRP A 345
PHE A 384
 None
 0.74A 5hw8H-4bf8A:
13.3		 5hw8H-4bf8A:
37.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bf8 FPR4

(Saccharomyces
cerevisiae) 		PF00254
(FKBP_C) 		6 TYR A 313
ASP A 324
VAL A 341
ILE A 342
TRP A 345
PHE A 384
 None
 0.58A 5hw8H-4bf8A:
13.3		 5hw8H-4bf8A:
37.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana) 		PF00343
(Phosphorylase) 		4 TYR A  87
PHE A 146
ILE A 832
TRP A 833
 None
 0.98A 5hw8H-4bqiA:
undetectable		 5hw8H-4bqiA:
9.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dz3 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Burkholderia
pseudomallei) 		PF00254
(FKBP_C) 		7 TYR A  33
ASP A  44
PHE A  53
VAL A  62
ILE A  63
TRP A  66
PHE A 106
 FK5  A 201 ( 3.9A)
FK5  A 201 (-3.5A)
FK5  A 201 (-4.1A)
FK5  A 201 ( 3.6A)
FK5  A 201 (-3.8A)
FK5  A 201 (-3.4A)
FK5  A 201 (-4.8A)
 0.58A 5hw8H-4dz3A:
15.2		 5hw8H-4dz3A:
47.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eco UNCHARACTERIZED
PROTEIN

(Bacteroides
eggerthii) 		no annotation 4 PHE A 536
VAL A 522
ILE A 546
ILE A 554
 None
 0.77A 5hw8H-4ecoA:
undetectable		 5hw8H-4ecoA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fnq ALPHA-GALACTOSIDASE
AGAB

(Geobacillus
stearothermophilus) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		4 ASP A 382
VAL A 455
ILE A 459
ILE A 384
 None
 0.71A 5hw8H-4fnqA:
undetectable		 5hw8H-4fnqA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl2 INTERFERON-INDUCED
HELICASE C
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF11648
(RIG-I_C-RD) 		4 TYR A 461
ASP A 514
ILE A 881
ILE A 873
 None
 0.99A 5hw8H-4gl2A:
undetectable		 5hw8H-4gl2A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ieg RNA-DEPENDENT RNA
POLYMERASE P2

(Pseudomonas
phage phi12) 		no annotation 5 TYR A 353
VAL A 434
ILE A 435
ILE A 362
PHE A 498
 None
 1.23A 5hw8H-4iegA:
undetectable		 5hw8H-4iegA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jrb GREEN FLUORESCENT
PROTEIN

(Aequorea
victoria;
Blattella
germanica) 		PF01353
(GFP)
PF06757
(Ins_allergen_rp) 		4 TYR A  92
PHE A  84
VAL A 163
ILE A 123
 None
 0.95A 5hw8H-4jrbA:
undetectable		 5hw8H-4jrbA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4

(Homo sapiens) 		PF00254
(FKBP_C) 		4 TYR A  57
ASP A  68
PHE A  77
ILE A 122
 None
 0.94A 5hw8H-4lawA:
14.8		 5hw8H-4lawA:
27.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4

(Homo sapiens) 		PF00254
(FKBP_C) 		7 TYR A  57
ASP A  68
PHE A  77
VAL A  86
ILE A  87
TRP A  90
PHE A 130
 None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
DMS  A 304 (-4.3A)
 0.69A 5hw8H-4lawA:
14.8		 5hw8H-4lawA:
27.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ldg PROTEIN WITH A SET
DOMAIN WITHIN
CARBOXY REGION

(Cryptosporidium
parvum) 		PF00856
(SET) 		4 PHE A  34
VAL A 111
ILE A 112
ILE A 251
 None
 0.95A 5hw8H-4ldgA:
undetectable		 5hw8H-4ldgA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n03 ABC-TYPE
BRANCHED-CHAIN AMINO
ACID TRANSPORT
SYSTEMS PERIPLASMIC
COMPONENT-LIKE
PROTEIN

(Thermomonospora
curvata) 		PF13458
(Peripla_BP_6) 		4 TYR A 198
PHE A 194
VAL A  63
ILE A 295
 PLM  A 601 (-3.9A)
None
None
None
 0.85A 5hw8H-4n03A:
undetectable		 5hw8H-4n03A:
18.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nnr PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP2

(Homo sapiens) 		PF00254
(FKBP_C) 		7 TYR A  56
ASP A  67
PHE A  76
VAL A  85
ILE A  86
TRP A  89
PHE A 129
 FK5  A 201 (-4.1A)
FK5  A 201 (-3.4A)
FK5  A 201 (-4.0A)
FK5  A 201 (-3.4A)
FK5  A 201 (-3.8A)
FK5  A 201 (-3.5A)
FK5  A 201 (-4.9A)
 0.58A 5hw8H-4nnrA:
13.7		 5hw8H-4nnrA:
36.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r0x PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5

(Homo sapiens) 		PF00254
(FKBP_C) 		4 TYR A  57
ASP A  68
PHE A  77
ILE A 122
 None
 0.89A 5hw8H-4r0xA:
14.6		 5hw8H-4r0xA:
40.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r0x PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5

(Homo sapiens) 		PF00254
(FKBP_C) 		4 TYR A  57
ASP A  68
PHE A  77
PHE A 130
 None
 0.60A 5hw8H-4r0xA:
14.6		 5hw8H-4r0xA:
40.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r0x PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5

(Homo sapiens) 		PF00254
(FKBP_C) 		5 TYR A  57
PHE A  77
VAL A  86
ILE A  87
TRP A  90
 None
 0.57A 5hw8H-4r0xA:
14.6		 5hw8H-4r0xA:
40.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r0x PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5

(Homo sapiens) 		PF00254
(FKBP_C) 		5 TYR A  57
PHE A  77
VAL A  86
TRP A  90
PHE A 130
 None
 0.72A 5hw8H-4r0xA:
14.6		 5hw8H-4r0xA:
40.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqv ALGM1
ALGM2

(Sphingomonas
sp.) 		PF00528
(BPD_transp_1) 		4 VAL A 203
ILE A 202
ILE B 207
PHE B 282
 None
 0.95A 5hw8H-4tqvA:
undetectable		 5hw8H-4tqvA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z4m GREEN FLUORESCENT
PROTEIN,TAX1-BINDING
PROTEIN 1

(Aequorea
victoria;
Homo sapiens) 		PF01353
(GFP) 		4 TYR A  92
PHE A  84
VAL A 163
ILE A 123
 None
 0.94A 5hw8H-4z4mA:
undetectable		 5hw8H-4z4mA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zv1 ANCQR

(synthetic
construct) 		PF00497
(SBP_bac_3) 		4 ASP A 167
PHE A 149
VAL A 101
ILE A 185
 ARG  A 301 (-2.9A)
None
None
None
 0.84A 5hw8H-4zv1A:
undetectable		 5hw8H-4zv1A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b48 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
BETA SUBUNIT

(Sulfurisphaera
tokodaii) 		PF02775
(TPP_enzyme_C)
PF12367
(PFO_beta_C) 		4 VAL B  29
ILE B  28
ILE B 114
PHE B  53
 None
 0.83A 5hw8H-5b48B:
undetectable		 5hw8H-5b48B:
18.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Coccidioides
immitis) 		PF00254
(FKBP_C) 		7 TYR C  36
ASP C  56
PHE C  64
VAL C  73
ILE C  74
TRP C  77
PHE C 117
 FK5  C 201 (-4.1A)
FK5  C 201 ( 3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.5A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.4A)
FK5  C 201 (-4.7A)
 0.56A 5hw8H-5b8iC:
15.2		 5hw8H-5b8iC:
37.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dbj FADH2-DEPENDENT
HALOGENASE PLTA

(Pseudomonas
protegens) 		no annotation 4 TYR E 299
ASP E 322
VAL E  44
PHE E 320
 FAD  E 501 ( 4.3A)
None
FAD  E 501 (-4.7A)
FAD  E 501 ( 4.2A)
 0.76A 5hw8H-5dbjE:
undetectable		 5hw8H-5dbjE:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF17137
(DUF5110) 		4 PHE A 196
VAL A 380
ILE A 274
PHE A 265
 None
 0.91A 5hw8H-5dkxA:
undetectable		 5hw8H-5dkxA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dm4 METHYLTRANSFERASE
DOMAIN FAMILY

(Bacillus
pumilus) 		PF13489
(Methyltransf_23) 		4 ASP A  65
ILE A 104
ILE A  63
PHE A 108
 SAH  A 300 ( 4.4A)
None
None
None
 0.86A 5hw8H-5dm4A:
undetectable		 5hw8H-5dm4A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e59 FRNE PROTEIN

(Deinococcus
radiodurans) 		PF01323
(DSBA) 		4 PHE A  32
VAL A  47
TRP A  49
ILE A 188
 None
 0.92A 5hw8H-5e59A:
undetectable		 5hw8H-5e59A:
20.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i7p PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A,FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A

(Escherichia
coli;
Homo sapiens) 		PF00254
(FKBP_C) 		7 TYR A  26
ASP A  37
PHE A  46
VAL A  55
ILE A  56
TRP A  59
PHE A 146
 None
 0.69A 5hw8H-5i7pA:
13.9		 5hw8H-5i7pA:
32.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i7q PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A,FKBP-TYPE 16
KDA PEPTIDYL-PROLYL
CIS-TRANS
ISOMERASE,PEPTIDYL-P
ROLYL CIS-TRANS
ISOMERASE FKBP1A

(Escherichia
coli;
Homo sapiens) 		PF00254
(FKBP_C) 		7 TYR A  26
ASP A  37
PHE A  46
VAL A  55
ILE A  56
TRP A  59
PHE A 147
 None
 0.61A 5hw8H-5i7qA:
14.1		 5hw8H-5i7qA:
32.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i98 FK506-BINDING
PROTEIN 1

(Candida
albicans) 		PF00254
(FKBP_C) 		4 PHE A  50
TRP A  63
ILE A 102
PHE A 114
 None
 0.80A 5hw8H-5i98A:
17.2		 5hw8H-5i98A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i98 FK506-BINDING
PROTEIN 1

(Candida
albicans) 		PF00254
(FKBP_C) 		8 TYR A  30
ASP A  41
PHE A  50
VAL A  59
ILE A  60
TRP A  63
ILE A 105
PHE A 114
 None
 0.62A 5hw8H-5i98A:
17.2		 5hw8H-5i98A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM

(Homo sapiens) 		PF00343
(Phosphorylase) 		4 TYR A  84
PHE A 143
ILE A 824
TRP A 825
 None
 0.93A 5hw8H-5ikpA:
undetectable		 5hw8H-5ikpA:
10.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j6e FK506-BINDING
PROTEIN 1A

(Aspergillus
fumigatus) 		PF00254
(FKBP_C) 		7 TYR A  27
ASP A  38
PHE A  47
VAL A  56
ILE A  57
TRP A  60
PHE A 100
 None
 0.67A 5hw8H-5j6eA:
15.9		 5hw8H-5j6eA:
46.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5je8 3-HYDROXYISOBUTYRATE
DEHYDROGENASE

(Bacillus cereus) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		4 TYR A  75
VAL A  89
ILE A 165
PHE A  82
 None
 0.91A 5hw8H-5je8A:
undetectable		 5hw8H-5je8A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE

(Hordeum vulgare) 		PF00343
(Phosphorylase) 		4 TYR A 131
PHE A 190
ILE A 959
TRP A 960
 None
 0.95A 5hw8H-5lrbA:
undetectable		 5hw8H-5lrbA:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ool 39S RIBOSOMAL
PROTEIN L37,
MITOCHONDRIAL

(Homo sapiens) 		PF07147
(PDCD9) 		4 PHE 5 352
VAL 5 181
ILE 5 185
ILE 5 147
 None
 0.94A 5hw8H-5ool5:
undetectable		 5hw8H-5ool5:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2g PENICILLIN-BINDING
PROTEIN 1A

(Haemophilus
influenzae) 		PF00905
(Transpeptidase)
PF00912
(Transgly)
PF17092
(PCB_OB) 		4 VAL A 684
ILE A 685
ILE A 458
PHE A 566
 None
 0.98A 5hw8H-5u2gA:
undetectable		 5hw8H-5u2gA:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8t UBIQUITIN-LIKE
PROTEIN
SMT3,PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Burkholderia
pseudomallei;
Saccharomyces
cerevisiae) 		no annotation 7 TYR A  33
ASP A  44
PHE A  53
VAL A  62
ILE A  63
TRP A  66
PHE A 106
 8ZV  A 201 (-3.8A)
8ZV  A 201 (-3.9A)
8ZV  A 201 (-3.9A)
8ZV  A 201 (-3.6A)
8ZV  A 201 (-4.0A)
8ZV  A 201 (-3.3A)
8ZV  A 201 (-4.6A)
 0.54A 5hw8H-5v8tA:
15.2		 5hw8H-5v8tA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wzk PUMILIO HOMOLOG 23

(Arabidopsis
thaliana) 		no annotation 4 VAL A 163
ILE A 167
ILE A 137
PHE A 156
 None
 0.95A 5hw8H-5wzkA:
undetectable		 5hw8H-5wzkA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xb0 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Pseudomonas
syringae group
genomosp. 3) 		PF00254
(FKBP_C) 		6 TYR A 147
ASP A 158
VAL A 171
ILE A 172
TRP A 175
PHE A 215
 TLA  A 301 ( 4.4A)
TLA  A 301 (-3.7A)
TLA  A 301 (-3.4A)
TLA  A 301 (-3.4A)
TLA  A 301 (-3.4A)
None
 0.78A 5hw8H-5xb0A:
12.8		 5hw8H-5xb0A:
27.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6r GENOME POLYPROTEIN

(Pestivirus C) 		no annotation 4 TYR A 257
PHE A 225
VAL A 121
ILE A 261
 None
GOL  A 731 (-4.0A)
None
None
 0.99A 5hw8H-5y6rA:
undetectable		 5hw8H-5y6rA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6t ENDO-1,4-BETA-MANNAN
ASE

(Eisenia fetida) 		no annotation 4 VAL A 234
ILE A 235
ILE A 374
PHE A 126
 None
 0.92A 5hw8H-5y6tA:
undetectable		 5hw8H-5y6tA:
21.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6b4p PEPTIDYLPROLYL
ISOMERASE

(Naegleria
fowleri) 		no annotation 7 TYR A  38
ASP A  49
PHE A  58
VAL A  67
ILE A  68
TRP A  71
PHE A 111
 None
 0.67A 5hw8H-6b4pA:
14.9		 5hw8H-6b4pA:
37.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6b4p PEPTIDYLPROLYL
ISOMERASE

(Naegleria
fowleri) 		no annotation 5 TYR A  38
PHE A  58
TRP A  71
ILE A  99
PHE A 111
 None
 1.11A 5hw8H-6b4pA:
14.9		 5hw8H-6b4pA:
37.68