SIMILAR PATTERNS OF AMINO ACIDS FOR 5HW8_G_FK5G201

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aug PYROGLUTAMYL
PEPTIDASE-1

(Bacillus
amyloliquefaciens) 		PF01470
(Peptidase_C15) 		3 ILE A 131
PRO A 132
ILE A 126
 None
 0.41A 5hw8F-1augA:
0.0		 5hw8F-1augA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b5t PROTEIN
(METHYLENETETRAHYDRO
FOLATE REDUCTASE)

(Escherichia
coli) 		PF02219
(MTHFR) 		3 ILE A 208
PRO A 209
ILE A 181
 None
None
FAD  A 395 ( 4.0A)
 0.38A 5hw8F-1b5tA:
0.0		 5hw8F-1b5tA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cle CHOLESTEROL ESTERASE

([Candida]
cylindracea) 		PF00135
(COesterase) 		3 ILE A  26
PRO A  27
ILE A 100
 None
 0.45A 5hw8F-1cleA:
0.0		 5hw8F-1cleA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dms DMSO REDUCTASE

(Rhodobacter
capsulatus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		3 ILE A 198
PRO A 199
ILE A 487
 None
 0.41A 5hw8F-1dmsA:
0.0		 5hw8F-1dmsA:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ey2 HOMOGENTISATE
1,2-DIOXYGENASE

(Homo sapiens) 		PF04209
(HgmA) 		3 ILE A 229
PRO A 230
ILE A   7
 None
 0.36A 5hw8F-1ey2A:
undetectable		 5hw8F-1ey2A:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1foh PHENOL HYDROXYLASE

(Cutaneotrichosporon
cutaneum) 		PF01494
(FAD_binding_3)
PF07976
(Phe_hydrox_dim) 		3 ILE A 100
PRO A 101
ILE A  83
 None
 0.30A 5hw8F-1fohA:
0.3		 5hw8F-1fohA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gze MONO-ADP-RIBOSYLTRAN
SFERASE C3

(Clostridium
botulinum) 		PF03496
(ADPrib_exo_Tox) 		3 ILE A 188
PRO A 187
ILE A 237
 None
 0.40A 5hw8F-1gzeA:
0.0		 5hw8F-1gzeA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ig8 HEXOKINASE PII

(Saccharomyces
cerevisiae) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		3 ILE A 180
PRO A 181
ILE A 183
 None
 0.26A 5hw8F-1ig8A:
0.0		 5hw8F-1ig8A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k91 CALRETICULIN

(Rattus
norvegicus) 		PF00262
(Calreticulin) 		3 ILE A 225
PRO A 226
ILE A 249
 None
 0.41A 5hw8F-1k91A:
undetectable		 5hw8F-1k91A:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l2q MONOMETHYLAMINE
METHYLTRANSFERASE

(Methanosarcina
barkeri) 		PF05369
(MtmB) 		3 ILE A  52
PRO A  53
ILE A 398
 None
 0.43A 5hw8F-1l2qA:
0.0		 5hw8F-1l2qA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n76 LACTOFERRIN

(Homo sapiens) 		PF00405
(Transferrin) 		3 ILE A  43
PRO A  42
ILE A  46
 None
 0.44A 5hw8F-1n76A:
undetectable		 5hw8F-1n76A:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nov NODAMURA VIRUS COAT
PROTEINS

(Nodamura virus) 		PF01829
(Peptidase_A6) 		3 ILE A 118
PRO A 119
ILE A 121
 None
 0.30A 5hw8F-1novA:
undetectable		 5hw8F-1novA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nt4 GLUCOSE-1-PHOSPHATAS
E

(Escherichia
coli) 		PF00328
(His_Phos_2) 		3 ILE A 112
PRO A 113
ILE A 103
 None
 0.39A 5hw8F-1nt4A:
undetectable		 5hw8F-1nt4A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pzt BETA-1,4-GALACTOSYLT
RANSFERASE 1

(Bos taurus) 		PF02709
(Glyco_transf_7C)
PF13733
(Glyco_transf_7N) 		3 ILE A 256
PRO A 257
ILE A 147
 None
 0.46A 5hw8F-1pztA:
undetectable		 5hw8F-1pztA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q6y HYPOTHETICAL PROTEIN
YFDW

(Escherichia
coli) 		PF02515
(CoA_transf_3) 		3 ILE A  54
PRO A  55
ILE A  57
 None
 0.26A 5hw8F-1q6yA:
undetectable		 5hw8F-1q6yA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qon ACETYLCHOLINESTERASE

(Drosophila
melanogaster) 		PF00135
(COesterase) 		3 ILE A  32
PRO A  33
ILE A  96
 None
 0.44A 5hw8F-1qonA:
undetectable		 5hw8F-1qonA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tjy SUGAR TRANSPORT
PROTEIN

(Salmonella
enterica) 		PF13407
(Peripla_BP_4) 		3 ILE A 296
PRO A 297
ILE A 299
 None
 0.40A 5hw8F-1tjyA:
undetectable		 5hw8F-1tjyA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1urh 3-MERCAPTOPYRUVATE
SULFURTRANSFERASE

(Escherichia
coli) 		PF00581
(Rhodanese) 		3 ILE A  46
PRO A  47
ILE A  22
 None
 0.43A 5hw8F-1urhA:
undetectable		 5hw8F-1urhA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wy2 XAA-PRO DIPEPTIDASE

(Pyrococcus
horikoshii) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		3 ILE A 321
PRO A 322
ILE A 324
 None
 0.35A 5hw8F-1wy2A:
undetectable		 5hw8F-1wy2A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y23 HISTIDINE TRIAD
PROTEIN

(Bacillus
subtilis) 		PF01230
(HIT) 		3 ILE A  17
PRO A  18
ILE A  12
 None
 0.41A 5hw8F-1y23A:
undetectable		 5hw8F-1y23A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yf2 TYPE I
RESTRICTION-MODIFICA
TION ENZYME, S
SUBUNIT

(Methanocaldococcus
jannaschii) 		PF01420
(Methylase_S) 		3 ILE A  51
PRO A  52
ILE A  73
 None
 0.36A 5hw8F-1yf2A:
undetectable		 5hw8F-1yf2A:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yt8 THIOSULFATE
SULFURTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00581
(Rhodanese) 		3 ILE A 163
PRO A 164
ILE A 149
 None
 0.45A 5hw8F-1yt8A:
undetectable		 5hw8F-1yt8A:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy8 DIHYDROLIPOYL
DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 ILE A 312
PRO A 313
ILE A 315
 None
 0.38A 5hw8F-1zy8A:
undetectable		 5hw8F-1zy8A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bov MONO-ADP-RIBOSYLTRAN
SFERASE C3

(Clostridium
botulinum) 		PF03496
(ADPrib_exo_Tox) 		3 ILE B1188
PRO B1187
ILE B1237
 None
 0.45A 5hw8F-2bovB:
undetectable		 5hw8F-2bovB:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2col BIFUNCTIONAL
HEMOLYSIN-ADENYLATE
CYCLASE

(Bordetella
pertussis) 		PF03497
(Anthrax_toxA) 		3 ILE A  76
PRO A  77
ILE A 177
 None
 0.37A 5hw8F-2colA:
undetectable		 5hw8F-2colA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dlg FILAMIN-B

(Homo sapiens) 		PF00630
(Filamin) 		3 ILE A  25
PRO A  26
ILE A  28
 None
 0.43A 5hw8F-2dlgA:
undetectable		 5hw8F-2dlgA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ds2 SWEET PROTEIN
MABINLIN-2 CHAIN B

(Capparis
masaikai) 		PF00234
(Tryp_alpha_amyl) 		3 ILE B  61
PRO B  62
ILE B  64
 None
 0.28A 5hw8F-2ds2B:
undetectable		 5hw8F-2ds2B:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f42 STIP1 HOMOLOGY AND
U-BOX CONTAINING
PROTEIN 1

(Danio rerio) 		PF04564
(U-box) 		3 ILE A 262
PRO A 263
ILE A 226
 None
 0.43A 5hw8F-2f42A:
undetectable		 5hw8F-2f42A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fim TUBBY RELATED
PROTEIN 1

(Homo sapiens) 		PF01167
(Tub) 		3 ILE A 372
PRO A 373
ILE A 406
 None
None
3DP  A1003 ( 4.8A)
 0.42A 5hw8F-2fimA:
undetectable		 5hw8F-2fimA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ilu ALDEHYDE
DEHYDROGENASE A

(Escherichia
coli) 		PF00171
(Aldedh) 		3 ILE A  38
PRO A  39
ILE A  24
 None
 0.41A 5hw8F-2iluA:
undetectable		 5hw8F-2iluA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2joi HYPOTHETICAL PROTEIN
TA0095

(Thermoplasma
acidophilum) 		no annotation 3 ILE A  61
PRO A  62
ILE A  64
 None
 0.31A 5hw8F-2joiA:
undetectable		 5hw8F-2joiA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n4p TAR DNA-BINDING
PROTEIN 43

(Homo sapiens) 		no annotation 3 ILE A  30
PRO A  31
ILE A  17
 None
 0.38A 5hw8F-2n4pA:
undetectable		 5hw8F-2n4pA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ppv UNCHARACTERIZED
PROTEIN

(Staphylococcus
epidermidis) 		PF01933
(UPF0052) 		3 ILE A 122
PRO A 123
ILE A  32
 None
 0.43A 5hw8F-2ppvA:
undetectable		 5hw8F-2ppvA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjp CYTOCHROME B

(Rhodobacter
sphaeroides) 		PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B) 		3 ILE A 169
PRO A 170
ILE A 172
 None
 0.41A 5hw8F-2qjpA:
undetectable		 5hw8F-2qjpA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Homo sapiens) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		3 ILE A 649
PRO A 650
ILE A 641
 None
 0.42A 5hw8F-2vxoA:
undetectable		 5hw8F-2vxoA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT

(Homo sapiens) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC) 		3 ILE A 669
PRO A 670
ILE A 672
 None
 0.46A 5hw8F-2wghA:
undetectable		 5hw8F-2wghA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwg SORTASE

(Actinomyces
oris) 		PF04203
(Sortase) 		3 ILE A 160
PRO A 161
ILE A 163
 None
 0.45A 5hw8F-2xwgA:
undetectable		 5hw8F-2xwgA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yh2 ESTERASE

(Pyrobaculum
calidifontis) 		PF07859
(Abhydrolase_3) 		3 ILE A  56
PRO A  57
ILE A  63
 None
 0.41A 5hw8F-2yh2A:
undetectable		 5hw8F-2yh2A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zyv TYROSINE-ESTER
SULFOTRANSFERASE

(Mus musculus) 		PF00685
(Sulfotransfer_1) 		3 ILE X  86
PRO X  87
ILE X  89
 None
None
NPO  X1602 (-4.2A)
 0.42A 5hw8F-2zyvX:
undetectable		 5hw8F-2zyvX:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3biw NEUROLIGIN-1

(Rattus
norvegicus) 		PF00135
(COesterase) 		3 ILE A 385
PRO A 386
ILE A 380
 None
 0.39A 5hw8F-3biwA:
undetectable		 5hw8F-3biwA:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bw8 MONO-ADP-RIBOSYLTRAN
SFERASE C3

(Hathewaya
limosa) 		PF03496
(ADPrib_exo_Tox) 		3 ILE A 148
PRO A 147
ILE A 197
 None
 0.45A 5hw8F-3bw8A:
undetectable		 5hw8F-3bw8A:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c5n TUBBY-RELATED
PROTEIN 1

(Homo sapiens) 		PF01167
(Tub) 		3 ILE A 372
PRO A 373
ILE A 406
 None
 0.46A 5hw8F-3c5nA:
undetectable		 5hw8F-3c5nA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egh SPINOPHILIN

(Rattus
norvegicus) 		PF00595
(PDZ) 		3 ILE C 434
PRO C 435
ILE C 456
 None
 0.42A 5hw8F-3eghC:
undetectable		 5hw8F-3eghC:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f9k INTEGRASE

(Human
immunodeficiency
virus 2) 		PF00665
(rve)
PF02022
(Integrase_Zn) 		3 ILE A  89
PRO A  90
ILE A  72
 None
 0.46A 5hw8F-3f9kA:
undetectable		 5hw8F-3f9kA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3frt CHARGED
MULTIVESICULAR BODY
PROTEIN 3

(Homo sapiens) 		PF03357
(Snf7) 		3 ILE A 120
PRO A 121
ILE A 123
 None
 0.44A 5hw8F-3frtA:
undetectable		 5hw8F-3frtA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1

(Homo sapiens) 		PF00632
(HECT) 		3 ILE A4234
PRO A4235
ILE A4239
 None
 0.44A 5hw8F-3g1nA:
undetectable		 5hw8F-3g1nA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g68 PUTATIVE
PHOSPHOSUGAR
ISOMERASE

(Clostridioides
difficile) 		PF01380
(SIS) 		3 ILE A 317
PRO A 316
ILE A 320
 None
 0.42A 5hw8F-3g68A:
undetectable		 5hw8F-3g68A:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gd7 FUSION COMPLEX OF
CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR, RESIDUES
1193-1427 AND
MALTOSE/MALTODEXTRIN
IMPORT ATP-BINDING
PROTEIN MALK,
RESIDUES 219-371

(Escherichia
coli;
Homo sapiens) 		PF00005
(ABC_tran)
PF08402
(TOBE_2) 		3 ILE A1529
PRO A1530
ILE A1532
 None
 0.43A 5hw8F-3gd7A:
undetectable		 5hw8F-3gd7A:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h84 ATPASE GET3

(Saccharomyces
cerevisiae) 		PF02374
(ArsA_ATPase) 		3 ILE A 133
PRO A 134
ILE A 136
 None
 0.36A 5hw8F-3h84A:
undetectable		 5hw8F-3h84A:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN

(Rhodobacter
sphaeroides) 		PF02126
(PTE) 		3 ILE A  21
PRO A  22
ILE A  14
 None
 0.44A 5hw8F-3k2gA:
undetectable		 5hw8F-3k2gA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nm1 THIAMINE
BIOSYNTHETIC
BIFUNCTIONAL ENZYME

([Candida]
glabrata) 		PF02110
(HK)
PF02581
(TMP-TENI) 		3 ILE A  98
PRO A  99
ILE A 101
 None
 0.35A 5hw8F-3nm1A:
undetectable		 5hw8F-3nm1A:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p1i EPHRIN TYPE-B
RECEPTOR 3

(Homo sapiens) 		PF01404
(Ephrin_lbd) 		3 ILE A 119
PRO A 120
ILE A 122
 None
 0.42A 5hw8F-3p1iA:
undetectable		 5hw8F-3p1iA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rlf MALTOSE/MALTODEXTRIN
IMPORT ATP-BINDING
PROTEIN MALK

(Escherichia
coli) 		PF00005
(ABC_tran)
PF08402
(TOBE_2) 		3 ILE A 320
PRO A 321
ILE A 323
 None
 0.34A 5hw8F-3rlfA:
undetectable		 5hw8F-3rlfA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t95 AUTOINDUCER
2-BINDING PROTEIN
LSRB

(Yersinia pestis) 		PF13407
(Peripla_BP_4) 		3 ILE A 295
PRO A 296
ILE A 298
 None
 0.38A 5hw8F-3t95A:
undetectable		 5hw8F-3t95A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3toy MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Bradyrhizobium
sp. ORS 278) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ILE A 242
PRO A 243
ILE A 221
 None
 0.45A 5hw8F-3toyA:
undetectable		 5hw8F-3toyA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4k FIMBRIA ADHESIN
PROTEIN

(Klebsiella
pneumoniae) 		no annotation 3 ILE A  96
PRO A  97
ILE A  99
 None
 0.40A 5hw8F-3u4kA:
undetectable		 5hw8F-3u4kA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ufc PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		PF01881
(Cas_Cas6) 		3 ILE X  16
PRO X  17
ILE X  68
 None
 0.45A 5hw8F-3ufcX:
undetectable		 5hw8F-3ufcX:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsc PROTEIN CYSO

(Aeropyrum
pernix) 		PF00291
(PALP) 		3 ILE A 293
PRO A 294
ILE A 296
 None
None
PLP  A 401 (-4.6A)
 0.33A 5hw8F-3vscA:
undetectable		 5hw8F-3vscA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfz LACTO-N-BIOSE
PHOSPHORYLASE

(Bifidobacterium
longum) 		PF09508
(Lact_bio_phlase)
PF17385
(LBP_M)
PF17386
(LBP_C) 		3 ILE A 179
PRO A 180
ILE A  64
 None
 0.41A 5hw8F-3wfzA:
undetectable		 5hw8F-3wfzA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4anj UNCONVENTIONAL
MYOSIN-VI, GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Sus scrofa) 		PF00063
(Myosin_head)
PF01353
(GFP) 		3 ILE A 103
PRO A 104
ILE A 106
 None
 0.40A 5hw8F-4anjA:
undetectable		 5hw8F-4anjA:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3h DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA190

(Saccharomyces
cerevisiae) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		3 ILE A1501
PRO A1502
ILE A1504
 None
 0.27A 5hw8F-4c3hA:
undetectable		 5hw8F-4c3hA:
5.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvu BETA-MANNOSIDASE

(Trichoderma
harzianum) 		PF00703
(Glyco_hydro_2) 		3 ILE A 554
PRO A 553
ILE A 546
 None
 0.45A 5hw8F-4cvuA:
undetectable		 5hw8F-4cvuA:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ezd UREA TRANSPORTER 1

(Bos taurus) 		PF03253
(UT) 		3 ILE A  71
PRO A  70
ILE A  74
 None
 0.45A 5hw8F-4ezdA:
undetectable		 5hw8F-4ezdA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1h SORTASE FAMILY
PROTEIN

(Streptococcus
agalactiae) 		PF04203
(Sortase) 		3 ILE A 112
PRO A 113
ILE A 115
 None
 0.45A 5hw8F-4g1hA:
undetectable		 5hw8F-4g1hA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h7n ALDEHYDE
DEHYDROGENASE

(Trichormus
variabilis) 		PF00171
(Aldedh) 		3 ILE A 112
PRO A 113
ILE A 115
 None
 0.43A 5hw8F-4h7nA:
undetectable		 5hw8F-4h7nA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i7u DIHYDRODIPICOLINATE
SYNTHASE

(Agrobacterium
sp. H13-3) 		PF00701
(DHDPS) 		3 ILE A   6
PRO A   7
ILE A 204
 None
 0.38A 5hw8F-4i7uA:
undetectable		 5hw8F-4i7uA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m6w FANCONI ANEMIA GROUP
M PROTEIN

(Homo sapiens) 		PF02732
(ERCC4) 		3 ILE A1979
PRO A1980
ILE A1982
 None
 0.45A 5hw8F-4m6wA:
undetectable		 5hw8F-4m6wA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4npb PROTEIN DISULFIDE
ISOMERASE II

(Yersinia pestis) 		PF10411
(DsbC_N)
PF13098
(Thioredoxin_2) 		3 ILE A  45
PRO A  46
ILE A  48
 None
 0.36A 5hw8F-4npbA:
undetectable		 5hw8F-4npbA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p9n CARBOXYLESTERASE

(Sulfolobus
shibatae) 		PF07859
(Abhydrolase_3) 		3 ILE A  51
PRO A  52
ILE A  58
 None
 0.43A 5hw8F-4p9nA:
undetectable		 5hw8F-4p9nA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pmw DIS3-LIKE
EXONUCLEASE 2

(Mus musculus) 		PF00773
(RNB)
PF17216
(Rrp44_CSD1) 		3 ILE A  85
PRO A  86
ILE A  94
 None
 0.37A 5hw8F-4pmwA:
undetectable		 5hw8F-4pmwA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r03 UNCHARACTERIZED
PROTEIN

(Parabacteroides
distasonis) 		PF12930
(DUF3836) 		3 ILE A 126
PRO A 127
ILE A 103
 None
 0.46A 5hw8F-4r03A:
undetectable		 5hw8F-4r03A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9g MBP1

(Caldanaerobius
polysaccharolyticus) 		PF13416
(SBP_bac_8) 		3 ILE A 311
PRO A 312
ILE A 101
 None
 0.42A 5hw8F-4r9gA:
undetectable		 5hw8F-4r9gA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u6d CONSERVED
HYPOTHETICAL
PERIPLASMIC PROTEIN

(Zobellia
galactanivorans) 		no annotation 3 ILE A 216
PRO A 217
ILE A 229
 None
 0.44A 5hw8F-4u6dA:
undetectable		 5hw8F-4u6dA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgx FAD:PROTEIN FMN
TRANSFERASE

(Escherichia
coli) 		PF02424
(ApbE) 		3 ILE A  31
PRO A  32
ILE A  34
 None
 0.44A 5hw8F-4xgxA:
undetectable		 5hw8F-4xgxA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zqv CDII IMMUNITY
PROTEIN

(Yersinia
kristensenii) 		PF07262
(CdiI) 		3 ILE A 143
PRO A 144
ILE A 117
 None
 0.42A 5hw8F-4zqvA:
undetectable		 5hw8F-4zqvA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahr DNA CROSS-LINK
REPAIR 1A PROTEIN

(Homo sapiens) 		PF07522
(DRMBL)
PF12706
(Lactamase_B_2) 		3 ILE A 913
PRO A 914
ILE A 916
 None
 0.45A 5hw8F-5ahrA:
undetectable		 5hw8F-5ahrA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ayd BETA-1,4-MANNOOLIGOS
ACCHARIDE
PHOSPHORYLASE

(Ruminococcus
albus) 		PF04041
(Glyco_hydro_130) 		3 ILE A  36
PRO A  37
ILE A  47
 None
 0.36A 5hw8F-5aydA:
undetectable		 5hw8F-5aydA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ghs SSDNA-SPECIFIC
EXONUCLEASE

(Thermococcus
kodakarensis) 		PF02272
(DHHA1) 		3 ILE A 219
PRO A 220
ILE A 222
 None
 0.39A 5hw8F-5ghsA:
undetectable		 5hw8F-5ghsA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7j ELONGATION FACTOR 2

(Pyrococcus
horikoshii) 		no annotation 3 ILE A 510
PRO A 511
ILE A 505
 None
 0.44A 5hw8F-5h7jA:
undetectable		 5hw8F-5h7jA:
18.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i98 FK506-BINDING
PROTEIN 1

(Candida
albicans) 		PF00254
(FKBP_C) 		3 ILE A 102
PRO A 103
ILE A 105
 None
 0.39A 5hw8F-5i98A:
18.9		 5hw8F-5i98A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5it5 ATP BINDING
MOTIF-CONTAINING
PROTEIN PILF

(Thermus
thermophilus) 		no annotation 3 ILE F 684
PRO F 685
ILE F 687
 None
 0.37A 5hw8F-5it5F:
undetectable		 5hw8F-5it5F:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j0a LYMPHOKINE-ACTIVATED
KILLER
T-CELL-ORIGINATED
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		3 ILE A 245
PRO A 246
ILE A 248
 None
 0.40A 5hw8F-5j0aA:
undetectable		 5hw8F-5j0aA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j98 VP3

(Slow bee
paralysis virus) 		PF00073
(Rhv) 		3 ILE C 150
PRO C 151
ILE C 153
 None
 0.37A 5hw8F-5j98C:
undetectable		 5hw8F-5j98C:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1

(Homo sapiens) 		no annotation 3 ILE B4234
PRO B4235
ILE B4239
 None
 0.46A 5hw8F-5lp8B:
undetectable		 5hw8F-5lp8B:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrg TAR DNA-BINDING
PROTEIN 43

(Homo sapiens) 		no annotation 3 ILE A  30
PRO A  31
ILE A  17
 None
 0.42A 5hw8F-5mrgA:
undetectable		 5hw8F-5mrgA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mxp -

(-) 		no annotation 3 ILE A 135
PRO A 136
ILE A 212
 None
 0.43A 5hw8F-5mxpA:
undetectable		 5hw8F-5mxpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5npr UDP-N-ACETYLGLUCOSAM
INE--PEPTIDE
N-ACETYLGLUCOSAMINYL
TRANSFERASE 110 KDA
SUBUNIT

(Homo sapiens) 		no annotation 3 ILE A 767
PRO A 768
ILE A 711
 None
 0.41A 5hw8F-5nprA:
undetectable		 5hw8F-5nprA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opg ENVELOPE
GLYCOPROTEIN GN

(Hantaan
orthohantavirus) 		PF01567
(Hanta_G1) 		3 ILE A 356
PRO A 357
ILE A 327
 None
 0.45A 5hw8F-5opgA:
undetectable		 5hw8F-5opgA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ti8 AMINOTRANSFERASE

(Pseudomonas sp.
M1) 		PF00202
(Aminotran_3) 		3 ILE A 179
PRO A 180
ILE A 182
 None
 0.27A 5hw8F-5ti8A:
undetectable		 5hw8F-5ti8A:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT

(Homo sapiens) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		3 ILE A 669
PRO A 670
ILE A 672
 None
 0.31A 5hw8F-5tusA:
undetectable		 5hw8F-5tusA:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u3c CTP SYNTHASE

(Escherichia
coli) 		PF00117
(GATase)
PF06418
(CTP_synth_N) 		3 ILE A 373
PRO A 374
ILE A 347
 None
 0.40A 5hw8F-5u3cA:
undetectable		 5hw8F-5u3cA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vg9 PROTEIN-S-ISOPRENYLC
YSTEINE
O-METHYLTRANSFERASE

(Tribolium
castaneum) 		no annotation 3 ILE A 273
PRO A 274
ILE A 276
 None
 0.46A 5hw8F-5vg9A:
undetectable		 5hw8F-5vg9A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y2v RUBISCO OPERON
TRANSCRIPTIONAL
REGULATOR

(Synechocystis
sp. PCC 6803) 		no annotation 3 ILE A 182
PRO A 183
ILE A 260
 None
 0.42A 5hw8F-5y2vA:
undetectable		 5hw8F-5y2vA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y2w RUBISCO OPERON
TRANSCRIPTIONAL
REGULATOR

(Synechocystis
sp. PCC 6803) 		no annotation 3 ILE A 182
PRO A 183
ILE A 260
 None
 0.41A 5hw8F-5y2wA:
undetectable		 5hw8F-5y2wA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yg7 RIBOSE
1,5-BISPHOSPHATE
ISOMERASE

(Pyrococcus
horikoshii) 		no annotation 3 ILE A 299
PRO A 300
ILE A 292
 None
 0.45A 5hw8F-5yg7A:
undetectable		 5hw8F-5yg7A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yk7 MAINTENANCE OF
MITOCHONDRIAL
MORPHOLOGY PROTEIN 1

(Zygosaccharomyces
rouxii) 		no annotation 3 ILE A 397
PRO A 398
ILE A 400
 None
 0.41A 5hw8F-5yk7A:
undetectable		 5hw8F-5yk7A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zdh TYPE II SECRETION
SYSTEM PROTEIN D

(Escherichia
coli) 		no annotation 3 ILE A 557
PRO A 558
ILE A 560
 None
 0.45A 5hw8F-5zdhA:
undetectable		 5hw8F-5zdhA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bk7 ELONGATION FACTOR G

(Enterococcus
faecalis) 		no annotation 3 ILE A 164
PRO A 165
ILE A 176
 None
 0.43A 5hw8F-6bk7A:
undetectable		 5hw8F-6bk7A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c4u FORKHEAD-ASSOCIATED
1

(Saccharomyces
cerevisiae) 		no annotation 3 ILE B  45
PRO B  44
ILE B  37
 None
 0.41A 5hw8F-6c4uB:
undetectable		 5hw8F-6c4uB:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE

(Rhodothermus
marinus) 		no annotation 3 ILE B  92
PRO B  93
ILE B  95
 None
 0.32A 5hw8F-6f0kB:
undetectable		 5hw8F-6f0kB:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bhe POLYGALACTURONASE

(Pectobacterium
carotovorum) 		PF00295
(Glyco_hydro_28) 		5 ASP A 224
VAL A 267
ILE A 242
ILE A 204
PHE A 247
 None
 1.20A 5hw8G-1bheA:
undetectable		 5hw8G-1bheA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ef9 METHYLMALONYL COA
DECARBOXYLASE

(Escherichia
coli) 		PF00378
(ECH_1) 		5 VAL A  16
ILE A  17
ILE A  92
ILE A  88
PHE A  19
 None
 1.11A 5hw8G-1ef9A:
undetectable		 5hw8G-1ef9A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila) 		PF00254
(FKBP_C)
PF01346
(FKBP_N) 		6 PHE A 153
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
 None
 1.08A 5hw8G-1fd9A:
15.4		 5hw8G-1fd9A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila) 		PF00254
(FKBP_C)
PF01346
(FKBP_N) 		8 TYR A 131
ASP A 142
VAL A 158
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
 None
 0.61A 5hw8G-1fd9A:
15.4		 5hw8G-1fd9A:
23.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fkk FK506 BINDING
PROTEIN

(Bos taurus) 		PF00254
(FKBP_C) 		9 TYR A  26
ASP A  37
PHE A  46
VAL A  55
ILE A  56
TRP A  59
TYR A  82
ILE A  91
PHE A  99
 None
 0.62A 5hw8G-1fkkA:
18.0		 5hw8G-1fkkA:
45.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fkk FK506 BINDING
PROTEIN

(Bos taurus) 		PF00254
(FKBP_C) 		6 TYR A  26
PHE A  46
TRP A  59
ILE A  90
ILE A  91
PHE A  99
 None
 1.36A 5hw8G-1fkkA:
18.0		 5hw8G-1fkkA:
45.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR

(Trypanosoma
cruzi) 		PF00254
(FKBP_C) 		6 PHE A 114
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 1.00A 5hw8G-1jvwA:
14.3		 5hw8G-1jvwA:
32.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR

(Trypanosoma
cruzi) 		PF00254
(FKBP_C) 		7 TYR A  92
ASP A 103
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.61A 5hw8G-1jvwA:
14.3		 5hw8G-1jvwA:
32.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR

(Trypanosoma
cruzi) 		PF00254
(FKBP_C) 		7 TYR A  92
VAL A 119
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.56A 5hw8G-1jvwA:
14.3		 5hw8G-1jvwA:
32.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kt1 FK506-BINDING
PROTEIN FKBP51

(Saimiri
boliviensis) 		PF00254
(FKBP_C)
PF00515
(TPR_1)
PF13181
(TPR_8) 		6 PHE A  77
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
 None
 1.44A 5hw8G-1kt1A:
14.6		 5hw8G-1kt1A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kt1 FK506-BINDING
PROTEIN FKBP51

(Saimiri
boliviensis) 		PF00254
(FKBP_C)
PF00515
(TPR_1)
PF13181
(TPR_8) 		7 PHE A  77
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
 None
 0.91A 5hw8G-1kt1A:
14.6		 5hw8G-1kt1A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kt1 FK506-BINDING
PROTEIN FKBP51

(Saimiri
boliviensis) 		PF00254
(FKBP_C)
PF00515
(TPR_1)
PF13181
(TPR_8) 		6 TYR A  57
PHE A  77
VAL A  86
ILE A  87
TRP A  90
ILE A 122
 None
 1.02A 5hw8G-1kt1A:
14.6		 5hw8G-1kt1A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kt1 FK506-BINDING
PROTEIN FKBP51

(Saimiri
boliviensis) 		PF00254
(FKBP_C)
PF00515
(TPR_1)
PF13181
(TPR_8) 		7 TYR A  57
PHE A  77
VAL A  86
ILE A  87
TRP A  90
ILE A 122
PHE A 130
 None
 0.74A 5hw8G-1kt1A:
14.6		 5hw8G-1kt1A:
18.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1n1a FKBP52

(Homo sapiens) 		PF00254
(FKBP_C) 		9 TYR A  57
ASP A  68
PHE A  77
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
 None
 0.62A 5hw8G-1n1aA:
16.6		 5hw8G-1n1aA:
36.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pbk FKBP25

(Homo sapiens) 		PF00254
(FKBP_C) 		7 TYR A 135
ASP A 146
VAL A 171
ILE A 172
TRP A 175
TYR A 198
ILE A 208
 RAP  A 225 (-3.9A)
RAP  A 225 (-3.0A)
RAP  A 225 (-3.5A)
RAP  A 225 (-3.9A)
RAP  A 225 (-3.4A)
RAP  A 225 (-4.6A)
RAP  A 225 ( 4.9A)
 1.41A 5hw8G-1pbkA:
17.4		 5hw8G-1pbkA:
40.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pbk FKBP25

(Homo sapiens) 		PF00254
(FKBP_C) 		8 TYR A 135
ASP A 146
VAL A 171
ILE A 172
TRP A 175
TYR A 198
ILE A 208
PHE A 216
 RAP  A 225 (-3.9A)
RAP  A 225 (-3.0A)
RAP  A 225 (-3.5A)
RAP  A 225 (-3.9A)
RAP  A 225 (-3.4A)
RAP  A 225 (-4.6A)
RAP  A 225 ( 4.9A)
None
 0.38A 5hw8G-1pbkA:
17.4		 5hw8G-1pbkA:
40.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q6h FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA

(Escherichia
coli) 		PF00254
(FKBP_C)
PF01346
(FKBP_N) 		6 PHE A 168
ILE A 174
TRP A 177
TYR A 200
ILE A 208
PHE A 216
 None
 1.43A 5hw8G-1q6hA:
15.2		 5hw8G-1q6hA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q6h FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA

(Escherichia
coli) 		PF00254
(FKBP_C)
PF01346
(FKBP_N) 		8 TYR A 146
ASP A 157
VAL A 173
ILE A 174
TRP A 177
TYR A 200
ILE A 208
PHE A 216
 None
 0.58A 5hw8G-1q6hA:
15.2		 5hw8G-1q6hA:
25.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1r9h FK506 BINDING
PROTEIN FAMILY

(Caenorhabditis
elegans) 		PF00254
(FKBP_C) 		9 TYR A  40
ASP A  51
PHE A  60
VAL A  69
ILE A  70
TRP A  73
TYR A  96
ILE A 105
PHE A 113
 None
 0.69A 5hw8G-1r9hA:
17.7		 5hw8G-1r9hA:
34.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ry2 ACETYL-COENZYME A
SYNTHETASE 1

(Saccharomyces
cerevisiae) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		5 PHE A 349
VAL A 466
ILE A 465
TYR A 454
ILE A 458
 None
 1.17A 5hw8G-1ry2A:
undetectable		 5hw8G-1ry2A:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u10 PENICILLIN-INSENSITI
VE MUREIN
ENDOPEPTIDASE

(Escherichia
coli) 		PF03411
(Peptidase_M74) 		5 VAL A  93
ILE A 121
ILE A 164
ILE A 176
PHE A  77
 None
 1.11A 5hw8G-1u10A:
undetectable		 5hw8G-1u10A:
17.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u79 FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
3

(Arabidopsis
thaliana) 		PF00254
(FKBP_C) 		8 TYR A  37
ASP A  48
VAL A  66
ILE A  67
TRP A  70
TYR A  99
ILE A 113
PHE A 121
 None
 0.54A 5hw8G-1u79A:
17.4		 5hw8G-1u79A:
40.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1yat FK506 BINDING
PROTEIN

(Saccharomyces
cerevisiae) 		PF00254
(FKBP_C) 		8 TYR A  26
ASP A  37
PHE A  46
VAL A  55
ILE A  56
TRP A  59
TYR A  82
ILE A  91
 FK5  A 108 ( 4.0A)
FK5  A 108 ( 3.3A)
FK5  A 108 ( 4.0A)
FK5  A 108 ( 3.4A)
FK5  A 108 ( 3.7A)
FK5  A 108 ( 3.6A)
FK5  A 108 ( 4.7A)
None
 1.49A 5hw8G-1yatA:
18.7		 5hw8G-1yatA:
55.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1yat FK506 BINDING
PROTEIN

(Saccharomyces
cerevisiae) 		PF00254
(FKBP_C) 		9 TYR A  26
ASP A  37
PHE A  46
VAL A  55
ILE A  56
TRP A  59
TYR A  82
ILE A  91
PHE A  99
 FK5  A 108 ( 4.0A)
FK5  A 108 ( 3.3A)
FK5  A 108 ( 4.0A)
FK5  A 108 ( 3.4A)
FK5  A 108 ( 3.7A)
FK5  A 108 ( 3.6A)
FK5  A 108 ( 4.7A)
None
None
 0.42A 5hw8G-1yatA:
18.7		 5hw8G-1yatA:
55.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bwl ANGIOGENIN

(Mus musculus) 		PF00074
(RnaseA) 		5 ASP A 115
PHE A 119
VAL A  77
ILE A  46
ILE A  56
 None
 1.21A 5hw8G-2bwlA:
undetectable		 5hw8G-2bwlA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dry 29-KDA
GALACTOSE-BINDING
LECTIN

(Lumbricus
terrestris) 		PF00652
(Ricin_B_lectin) 		5 PHE A 134
VAL A 214
ILE A 219
ILE A 198
ILE A 242
 None
 1.26A 5hw8G-2dryA:
undetectable		 5hw8G-2dryA:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iwa GLUTAMINE
CYCLOTRANSFERASE

(Carica papaya) 		PF05096
(Glu_cyclase_2) 		5 ASP A 194
VAL A  33
ILE A 255
ILE A 210
ILE A 196
 None
 1.26A 5hw8G-2iwaA:
undetectable		 5hw8G-2iwaA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jfw GLUTAMATE RACEMASE

(Enterococcus
faecium) 		PF01177
(Asp_Glu_race) 		5 VAL A  99
ILE A 100
TYR A 130
ILE A 185
ILE A 118
 None
 1.19A 5hw8G-2jfwA:
undetectable		 5hw8G-2jfwA:
18.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2lpv FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Aedes aegypti) 		PF00254
(FKBP_C) 		5 TYR A  27
PHE A  47
ILE A  57
TRP A  60
ILE A  92
 None
 1.04A 5hw8G-2lpvA:
15.7		 5hw8G-2lpvA:
46.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2lpv FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Aedes aegypti) 		PF00254
(FKBP_C) 		5 TYR A  27
VAL A  56
ILE A  57
TRP A  60
ILE A  92
 None
 1.08A 5hw8G-2lpvA:
15.7		 5hw8G-2lpvA:
46.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE

(Nostoc
punctiforme) 		PF00221
(Lyase_aromatic) 		5 TYR A 475
VAL A 249
ILE A 323
ILE A 326
PHE A 472
 None
 1.22A 5hw8G-2nyfA:
undetectable		 5hw8G-2nyfA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2paj PUTATIVE
CYTOSINE/GUANINE
DEAMINASE

(unidentified) 		PF01979
(Amidohydro_1) 		5 ASP A  38
VAL A 408
ILE A  46
ILE A  20
ILE A  68
 None
 1.05A 5hw8G-2pajA:
undetectable		 5hw8G-2pajA:
13.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2pbc FK506-BINDING
PROTEIN 2

(Homo sapiens) 		PF00254
(FKBP_C) 		9 TYR A  56
ASP A  67
PHE A  76
VAL A  85
ILE A  86
TRP A  89
TYR A 112
ILE A 121
PHE A 129
 PEG  A 201 (-4.4A)
None
PEG  A 201 ( 3.9A)
PEG  A 201 (-3.6A)
PEG  A 201 (-3.8A)
PEG  A 201 (-3.7A)
None
None
None
 0.72A 5hw8G-2pbcA:
14.5		 5hw8G-2pbcA:
44.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vcd OUTER MEMBRANE
PROTEIN MIP

(Legionella
pneumophila) 		PF00254
(FKBP_C)
PF01346
(FKBP_N) 		5 ASP A  66
VAL A  82
ILE A  83
TRP A  86
PHE A 126
 RAP  A 138 (-2.7A)
RAP  A 138 (-3.2A)
RAP  A 138 (-3.6A)
RAP  A 138 (-2.3A)
RAP  A 138 ( 4.7A)
 0.75A 5hw8G-2vcdA:
13.1		 5hw8G-2vcdA:
34.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vcd OUTER MEMBRANE
PROTEIN MIP

(Legionella
pneumophila) 		PF00254
(FKBP_C)
PF01346
(FKBP_N) 		6 TYR A  55
ASP A  66
VAL A  82
ILE A  83
TRP A  86
TYR A 109
 RAP  A 138 (-2.6A)
RAP  A 138 (-2.7A)
RAP  A 138 (-3.2A)
RAP  A 138 (-3.6A)
RAP  A 138 (-2.3A)
RAP  A 138 (-3.8A)
 0.89A 5hw8G-2vcdA:
13.1		 5hw8G-2vcdA:
34.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vn1 70 KDA
PEPTIDYLPROLYL
ISOMERASE

(Plasmodium
falciparum) 		PF00254
(FKBP_C) 		9 TYR A  44
ASP A  56
PHE A  65
VAL A  74
ILE A  75
TRP A  78
TYR A 101
ILE A 110
PHE A 118
 FK5  A 501 (-4.1A)
FK5  A 501 (-3.4A)
FK5  A 501 (-4.1A)
FK5  A 501 (-3.5A)
FK5  A 501 (-4.3A)
FK5  A 501 (-3.3A)
FK5  A 501 (-4.7A)
None
FK5  A 501 (-4.8A)
 0.45A 5hw8G-2vn1A:
17.4		 5hw8G-2vn1A:
33.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ww8 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
pneumoniae) 		PF13519
(VWA_2) 		5 PHE A 358
VAL A 441
TYR A 503
ILE A 396
ILE A 512
 None
 1.24A 5hw8G-2ww8A:
undetectable		 5hw8G-2ww8A:
10.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2y78 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Burkholderia
pseudomallei) 		PF00254
(FKBP_C) 		8 TYR A  33
ASP A  44
PHE A  53
ILE A  63
TRP A  66
TYR A  89
ILE A  98
PHE A 106
 None
 0.64A 5hw8G-2y78A:
16.5		 5hw8G-2y78A:
47.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2y78 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Burkholderia
pseudomallei) 		PF00254
(FKBP_C) 		8 TYR A  33
PHE A  53
VAL A  62
ILE A  63
TRP A  66
TYR A  89
ILE A  98
PHE A 106
 None
 0.50A 5hw8G-2y78A:
16.5		 5hw8G-2y78A:
47.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b7x FK506-BINDING
PROTEIN 6

(Homo sapiens) 		PF00254
(FKBP_C) 		5 TYR A  61
ASP A  73
TYR A 118
ILE A 127
PHE A 135
 None
 0.78A 5hw8G-3b7xA:
13.4		 5hw8G-3b7xA:
27.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2t BASEPLATE STRUCTURAL
PROTEIN GP6

(Escherichia
virus T4) 		no annotation 5 VAL A 541
ILE A 540
ILE A 609
ILE A 606
PHE A 515
 None
 1.20A 5hw8G-3h2tA:
undetectable		 5hw8G-3h2tA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmp ELONGATION FACTOR TU
2, ELONGATION FACTOR
TS

(Escherichia
coli) 		PF00009
(GTP_EFTU)
PF00889
(EF_TS)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		5 ASP A  97
VAL A  75
ILE A 131
ILE A  71
PHE A 114
 None
 1.26A 5hw8G-3mmpA:
undetectable		 5hw8G-3mmpA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o5d PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5

(Homo sapiens) 		PF00254
(FKBP_C) 		8 TYR A  57
ASP A  68
PHE A  77
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
 None
 0.73A 5hw8G-3o5dA:
16.6		 5hw8G-3o5dA:
27.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o5d PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5

(Homo sapiens) 		PF00254
(FKBP_C) 		7 TYR A  57
PHE A  77
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
 None
 1.42A 5hw8G-3o5dA:
16.6		 5hw8G-3o5dA:
27.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o5d PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5

(Homo sapiens) 		PF00254
(FKBP_C) 		8 TYR A  57
PHE A  77
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
 None
 0.67A 5hw8G-3o5dA:
16.6		 5hw8G-3o5dA:
27.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o5e PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5

(Homo sapiens) 		PF00254
(FKBP_C) 		7 PHE A  77
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
 None
 0.81A 5hw8G-3o5eA:
16.9		 5hw8G-3o5eA:
39.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o5e PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5

(Homo sapiens) 		PF00254
(FKBP_C) 		7 TYR A  57
ASP A  68
PHE A  77
ILE A  87
TYR A 113
ILE A 122
PHE A 130
 None
 0.74A 5hw8G-3o5eA:
16.9		 5hw8G-3o5eA:
39.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o5e PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5

(Homo sapiens) 		PF00254
(FKBP_C) 		7 TYR A  57
PHE A  77
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
 None
 0.75A 5hw8G-3o5eA:
16.9		 5hw8G-3o5eA:
39.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pa7 70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE

(Plasmodium
vivax) 		PF00254
(FKBP_C) 		9 TYR A  43
ASP A  55
PHE A  64
VAL A  73
ILE A  74
TRP A  77
TYR A 100
ILE A 109
PHE A 117
 None
 0.70A 5hw8G-3pa7A:
17.0		 5hw8G-3pa7A:
36.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3um6 BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Plasmodium
falciparum) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		5 TYR A 569
VAL A 210
ILE A 224
TYR A 226
ILE A 200
 None
 1.15A 5hw8G-3um6A:
undetectable		 5hw8G-3um6A:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bf8 FPR4

(Saccharomyces
cerevisiae) 		PF00254
(FKBP_C) 		7 ASP A 324
VAL A 341
ILE A 342
TRP A 345
TYR A 368
ILE A 376
PHE A 384
 None
 0.80A 5hw8G-4bf8A:
14.9		 5hw8G-4bf8A:
37.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bf8 FPR4

(Saccharomyces
cerevisiae) 		PF00254
(FKBP_C) 		6 TYR A 313
ASP A 324
ILE A 342
TRP A 345
ILE A 376
PHE A 384
 None
 1.46A 5hw8G-4bf8A:
14.9		 5hw8G-4bf8A:
37.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bf8 FPR4

(Saccharomyces
cerevisiae) 		PF00254
(FKBP_C) 		6 TYR A 313
ASP A 324
PHE A 332
VAL A 341
TRP A 345
PHE A 384
 None
 0.92A 5hw8G-4bf8A:
14.9		 5hw8G-4bf8A:
37.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bf8 FPR4

(Saccharomyces
cerevisiae) 		PF00254
(FKBP_C) 		7 TYR A 313
ASP A 324
VAL A 341
ILE A 342
TRP A 345
ILE A 376
PHE A 384
 None
 0.79A 5hw8G-4bf8A:
14.9		 5hw8G-4bf8A:
37.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dip PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP14

(Homo sapiens) 		PF00254
(FKBP_C) 		5 TYR A  52
TRP A  88
TYR A 111
ILE A 119
PHE A 127
 None
 0.50A 5hw8G-4dipA:
16.5		 5hw8G-4dipA:
34.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dz3 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Burkholderia
pseudomallei) 		PF00254
(FKBP_C) 		9 TYR A  33
ASP A  44
PHE A  53
VAL A  62
ILE A  63
TRP A  66
TYR A  89
ILE A  98
PHE A 106
 FK5  A 201 ( 3.9A)
FK5  A 201 (-3.5A)
FK5  A 201 (-4.1A)
FK5  A 201 ( 3.6A)
FK5  A 201 (-3.8A)
FK5  A 201 (-3.4A)
FK5  A 201 (-4.7A)
None
FK5  A 201 (-4.8A)
 0.47A 5hw8G-4dz3A:
17.5		 5hw8G-4dz3A:
47.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fhn NUCLEOPORIN NUP120

(Schizosaccharomyces
pombe) 		PF11715
(Nup160) 		5 VAL B 115
ILE B 131
ILE B 183
ILE B 195
PHE B 167
 None
 1.25A 5hw8G-4fhnB:
undetectable		 5hw8G-4fhnB:
8.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gyi RIO2 KINASE

(Chaetomium
thermophilum) 		PF01163
(RIO1)
PF09202
(Rio2_N) 		5 ASP A 229
VAL A 277
ILE A 217
ILE A 235
ILE A 255
 PHD  A 257 ( 4.0A)
None
None
None
None
 1.15A 5hw8G-4gyiA:
undetectable		 5hw8G-4gyiA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h09 HYPOTHETICAL LEUCINE
RICH REPEAT PROTEIN

(Eubacterium
ventriosum) 		PF13306
(LRR_5) 		5 PHE A 337
VAL A 346
ILE A 369
ILE A 375
PHE A 383
 None
 1.11A 5hw8G-4h09A:
undetectable		 5hw8G-4h09A:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h09 HYPOTHETICAL LEUCINE
RICH REPEAT PROTEIN

(Eubacterium
ventriosum) 		PF13306
(LRR_5) 		5 TYR A 127
VAL A 172
ILE A 171
ILE A 158
ILE A 162
 EDO  A 504 (-3.8A)
None
None
None
None
 1.22A 5hw8G-4h09A:
undetectable		 5hw8G-4h09A:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hbk ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B4
(ALDOSE REDUCTASE)

(Schistosoma
japonicum) 		PF00248
(Aldo_ket_red) 		5 VAL A 254
ILE A  15
TYR A  39
ILE A 264
ILE A  37
 None
 1.03A 5hw8G-4hbkA:
undetectable		 5hw8G-4hbkA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		5 TYR A 669
ASP A 625
PHE A 600
ILE A 619
ILE A 590
 None
 1.19A 5hw8G-4htzA:
undetectable		 5hw8G-4htzA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ijm CIRCADIAN CLOCK
PROTEIN KINASE KAIC

(Synechococcus
elongatus) 		PF06745
(ATPase) 		5 ASP A 122
PHE A 151
ILE A 144
ILE A 127
PHE A  76
 None
 0.95A 5hw8G-4ijmA:
undetectable		 5hw8G-4ijmA:
15.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4iqc PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1B

(Homo sapiens) 		PF00254
(FKBP_C) 		6 PHE A  46
VAL A  55
ILE A  56
TYR A  82
ILE A  91
PHE A  99
 None
 0.77A 5hw8G-4iqcA:
17.9		 5hw8G-4iqcA:
46.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4iqc PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1B

(Homo sapiens) 		PF00254
(FKBP_C) 		7 TYR A  26
ASP A  37
PHE A  46
ILE A  56
TYR A  82
ILE A  91
PHE A  99
 None
 0.84A 5hw8G-4iqcA:
17.9		 5hw8G-4iqcA:
46.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4

(Homo sapiens) 		PF00254
(FKBP_C) 		8 TYR A  57
ASP A  68
PHE A  77
VAL A  86
ILE A  87
TRP A  90
ILE A 122
PHE A 130
 None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
DMS  A 304 (-4.3A)
 0.71A 5hw8G-4lawA:
17.3		 5hw8G-4lawA:
27.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4

(Homo sapiens) 		PF00254
(FKBP_C) 		7 TYR A  57
PHE A  77
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
 None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
None
 1.36A 5hw8G-4lawA:
17.3		 5hw8G-4lawA:
27.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4

(Homo sapiens) 		PF00254
(FKBP_C) 		8 TYR A  57
PHE A  77
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
 None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
None
DMS  A 304 (-4.3A)
 0.59A 5hw8G-4lawA:
17.3		 5hw8G-4lawA:
27.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4msp PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP14

(Homo sapiens) 		PF00254
(FKBP_C)
PF13499
(EF-hand_7) 		5 TYR A  33
TRP A  69
TYR A  92
ILE A 100
PHE A 108
 None
 0.36A 5hw8G-4mspA:
17.1		 5hw8G-4mspA:
26.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nnr PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP2

(Homo sapiens) 		PF00254
(FKBP_C) 		9 TYR A  56
ASP A  67
PHE A  76
VAL A  85
ILE A  86
TRP A  89
TYR A 112
ILE A 121
PHE A 129
 FK5  A 201 (-4.1A)
FK5  A 201 (-3.4A)
FK5  A 201 (-4.0A)
FK5  A 201 (-3.4A)
FK5  A 201 (-3.8A)
FK5  A 201 (-3.5A)
FK5  A 201 (-4.5A)
None
FK5  A 201 (-4.9A)
 0.41A 5hw8G-4nnrA:
15.0		 5hw8G-4nnrA:
36.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4odm PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD

(Thermus
thermophilus) 		PF00254
(FKBP_C) 		5 TYR A  13
ASP A  23
ILE A  37
TYR A  63
PHE A 128
 None
 0.54A 5hw8G-4odmA:
11.1		 5hw8G-4odmA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4odr PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA

(Homo sapiens;
Thermus
thermophilus) 		PF00254
(FKBP_C) 		6 TYR A  13
ASP A  23
ILE A  37
TYR A  63
ILE A  72
PHE A  80
 FK5  A 201 ( 3.6A)
FK5  A 201 (-3.6A)
FK5  A 201 (-3.9A)
FK5  A 201 (-4.4A)
None
FK5  A 201 ( 4.8A)
 0.42A 5hw8G-4odrA:
12.6		 5hw8G-4odrA:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qre METHIONYL-TRNA
SYNTHETASE

(Staphylococcus
aureus) 		PF08264
(Anticodon_1)
PF09334
(tRNA-synt_1g) 		5 TYR A  13
ILE A  88
TRP A  83
TYR A  46
ILE A   8
 ATP  A 602 (-4.5A)
None
None
None
None
 1.14A 5hw8G-4qreA:
undetectable		 5hw8G-4qreA:
12.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r0x PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5

(Homo sapiens) 		PF00254
(FKBP_C) 		8 TYR A  57
ASP A  68
PHE A  77
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
 None
 0.82A 5hw8G-4r0xA:
17.5		 5hw8G-4r0xA:
40.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r0x PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5

(Homo sapiens) 		PF00254
(FKBP_C) 		8 TYR A  57
PHE A  77
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
 None
 0.73A 5hw8G-4r0xA:
17.5		 5hw8G-4r0xA:
40.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7l CAS6B

(Methanococcus
maripaludis) 		PF17262
(DUF5328) 		5 TYR A  31
ILE A  63
TYR A  10
ILE A  94
PHE A  27
 None
 1.24A 5hw8G-4z7lA:
undetectable		 5hw8G-4z7lA:
20.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Coccidioides
immitis) 		PF00254
(FKBP_C) 		9 TYR C  36
ASP C  56
PHE C  64
VAL C  73
ILE C  74
TRP C  77
TYR C 100
ILE C 109
PHE C 117
 FK5  C 201 (-4.1A)
FK5  C 201 ( 3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.5A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.4A)
FK5  C 201 (-4.5A)
None
FK5  C 201 (-4.7A)
 0.32A 5hw8G-5b8iC:
18.1		 5hw8G-5b8iC:
37.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL

(Homo sapiens) 		PF00117
(GATase)
PF00988
(CPSase_sm_chain)
PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		5 PHE A 192
VAL A  49
ILE A  48
ILE A 172
ILE A 173
 None
 1.21A 5hw8G-5dotA:
undetectable		 5hw8G-5dotA:
6.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hsb RNA POLYMERASE

(Andes
orthohantavirus) 		no annotation 5 PHE A  92
VAL A 135
ILE A 154
ILE A 101
PHE A 108
 None
 1.19A 5hw8G-5hsbA:
undetectable		 5hw8G-5hsbA:
20.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i7p PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A,FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A

(Escherichia
coli;
Homo sapiens) 		PF00254
(FKBP_C) 		8 TYR A  26
ASP A  37
PHE A  46
VAL A  55
ILE A  56
TRP A  59
TYR A  82
PHE A 146
 None
 0.59A 5hw8G-5i7pA:
16.5		 5hw8G-5i7pA:
32.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i7q PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A,FKBP-TYPE 16
KDA PEPTIDYL-PROLYL
CIS-TRANS
ISOMERASE,PEPTIDYL-P
ROLYL CIS-TRANS
ISOMERASE FKBP1A

(Escherichia
coli;
Homo sapiens) 		PF00254
(FKBP_C) 		8 TYR A  26
ASP A  37
PHE A  46
VAL A  55
ILE A  56
TRP A  59
TYR A  82
PHE A 147
 None
 0.54A 5hw8G-5i7qA:
16.8		 5hw8G-5i7qA:
32.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i98 FK506-BINDING
PROTEIN 1

(Candida
albicans) 		PF00254
(FKBP_C) 		8 TYR A  30
ASP A  41
PHE A  50
VAL A  59
ILE A  60
TRP A  63
TYR A  97
ILE A 102
 None
 1.22A 5hw8G-5i98A:
23.5		 5hw8G-5i98A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i98 FK506-BINDING
PROTEIN 1

(Candida
albicans) 		PF00254
(FKBP_C) 		10 TYR A  30
ASP A  41
PHE A  50
VAL A  59
ILE A  60
TRP A  63
TYR A  97
ILE A 102
ILE A 106
PHE A 114
 None
 0.60A 5hw8G-5i98A:
23.5		 5hw8G-5i98A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i98 FK506-BINDING
PROTEIN 1

(Candida
albicans) 		PF00254
(FKBP_C) 		6 TYR A  30
PHE A  50
TRP A  63
ILE A 105
ILE A 106
PHE A 114
 None
 1.32A 5hw8G-5i98A:
23.5		 5hw8G-5i98A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j6e FK506-BINDING
PROTEIN 1A

(Aspergillus
fumigatus) 		PF00254
(FKBP_C) 		9 TYR A  27
ASP A  38
PHE A  47
VAL A  56
ILE A  57
TRP A  60
TYR A  83
ILE A  92
PHE A 100
 None
 0.64A 5hw8G-5j6eA:
18.4		 5hw8G-5j6eA:
46.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jcv LMO2181 PROTEIN

(Listeria
monocytogenes) 		PF04203
(Sortase) 		5 ASP A 125
VAL A  75
ILE A  89
TYR A 161
ILE A 221
 None
 1.15A 5hw8G-5jcvA:
undetectable		 5hw8G-5jcvA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8f ACETYL-COENZYME A
SYNTHETASE

(Cryptococcus
neoformans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		5 PHE A 318
VAL A 435
ILE A 434
TYR A 423
ILE A 386
 None
 1.18A 5hw8G-5k8fA:
undetectable		 5hw8G-5k8fA:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncs SERPIN

(Tannerella
forsythia) 		PF00079
(Serpin) 		5 VAL A 396
ILE A 397
ILE A 287
ILE A 286
PHE A  49
 None
 1.26A 5hw8G-5ncsA:
undetectable		 5hw8G-5ncsA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5non S-NORCOCLAURINE
SYNTHASE

(Thalictrum
flavum) 		PF00407
(Bet_v_1) 		5 ASP A 185
ILE A 143
TYR A  63
ILE A  59
ILE A 187
 None
 1.14A 5hw8G-5nonA:
undetectable		 5hw8G-5nonA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o6u UNCHARACTERIZED
PROTEIN

(Shewanella
putrefaciens) 		no annotation 5 TYR F  81
VAL F 301
ILE F 299
ILE F 334
PHE F  82
 None
 1.02A 5hw8G-5o6uF:
undetectable		 5hw8G-5o6uF:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8f ORIGIN RECOGNITION
COMPLEX SUBUNIT 2

(Saccharomyces
cerevisiae) 		PF04084
(ORC2) 		5 PHE B 437
VAL B 375
ILE B 379
ILE B 450
ILE B 447
 None
 1.19A 5hw8G-5v8fB:
undetectable		 5hw8G-5v8fB:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8t UBIQUITIN-LIKE
PROTEIN
SMT3,PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Burkholderia
pseudomallei;
Saccharomyces
cerevisiae) 		no annotation 9 TYR A  33
ASP A  44
PHE A  53
VAL A  62
ILE A  63
TRP A  66
TYR A  89
ILE A  98
PHE A 106
 8ZV  A 201 (-3.8A)
8ZV  A 201 (-3.9A)
8ZV  A 201 (-3.9A)
8ZV  A 201 (-3.6A)
8ZV  A 201 (-4.0A)
8ZV  A 201 (-3.3A)
8ZV  A 201 (-4.6A)
8ZV  A 201 ( 4.8A)
8ZV  A 201 (-4.6A)
 0.43A 5hw8G-5v8tA:
17.4		 5hw8G-5v8tA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x00 NUCLEOSIDE
DIPHOSPHATE KINASE

(Vibrio cholerae) 		no annotation 5 PHE A 133
ILE A  34
TYR A  24
ILE A  20
ILE A  23
 None
 1.06A 5hw8G-5x00A:
undetectable		 5hw8G-5x00A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xb0 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Pseudomonas
syringae group
genomosp. 3) 		PF00254
(FKBP_C) 		6 PHE A 166
ILE A 172
TRP A 175
TYR A 198
ILE A 207
PHE A 215
 TLA  A 301 ( 4.6A)
TLA  A 301 (-3.4A)
TLA  A 301 (-3.4A)
None
None
None
 1.06A 5hw8G-5xb0A:
15.2		 5hw8G-5xb0A:
27.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xb0 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Pseudomonas
syringae group
genomosp. 3) 		PF00254
(FKBP_C) 		8 TYR A 147
ASP A 158
VAL A 171
ILE A 172
TRP A 175
TYR A 198
ILE A 207
PHE A 215
 TLA  A 301 ( 4.4A)
TLA  A 301 (-3.7A)
TLA  A 301 (-3.4A)
TLA  A 301 (-3.4A)
TLA  A 301 (-3.4A)
None
None
None
 0.68A 5hw8G-5xb0A:
15.2		 5hw8G-5xb0A:
27.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z0y SERINE
HYDROXYMETHYLTRANSFE
RASE

(Komagataella
phaffii) 		no annotation 5 TYR A 339
ASP A 418
ILE A 395
ILE A 374
PHE A 334
 None
 1.18A 5hw8G-5z0yA:
undetectable		 5hw8G-5z0yA:
18.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6b4p PEPTIDYLPROLYL
ISOMERASE

(Naegleria
fowleri) 		no annotation 8 TYR A  38
ASP A  49
PHE A  58
VAL A  67
ILE A  68
TRP A  71
TYR A  94
ILE A  99
 None
 1.40A 5hw8G-6b4pA:
17.2		 5hw8G-6b4pA:
37.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6b4p PEPTIDYLPROLYL
ISOMERASE

(Naegleria
fowleri) 		no annotation 9 TYR A  38
ASP A  49
PHE A  58
VAL A  67
ILE A  68
TRP A  71
TYR A  94
ILE A  99
PHE A 111
 None
 0.58A 5hw8G-6b4pA:
17.2		 5hw8G-6b4pA:
37.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6b4p PEPTIDYLPROLYL
ISOMERASE

(Naegleria
fowleri) 		no annotation 9 TYR A  38
ASP A  49
PHE A  58
VAL A  67
ILE A  68
TYR A  94
ILE A  99
ILE A 103
PHE A 111
 None
 0.52A 5hw8G-6b4pA:
17.2		 5hw8G-6b4pA:
37.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH DEHYDROGENASE
[UBIQUINONE]
FLAVOPROTEIN 1,
MITOCHONDRIAL

(Mus musculus) 		no annotation 5 TYR F 354
VAL F 415
ILE F 347
ILE F 298
ILE F 335
 None
 1.11A 5hw8G-6g2jF:
undetectable		 5hw8G-6g2jF:
21.30