SIMILAR PATTERNS OF AMINO ACIDS FOR 5HW4_B_SAMB801

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1anu COHESIN-2

(Ruminiclostridium
thermocellum) 		PF00963
(Cohesin) 		5 ILE A  46
GLY A  48
ASP A  50
ALA A 101
LEU A  44
 None
 1.34A 5hw4B-1anuA:
undetectable		 5hw4B-1anuA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b0a PROTEIN (FOLD
BIFUNCTIONAL
PROTEIN)

(Escherichia
coli) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		5 ILE A  92
GLY A  35
ALA A  37
LEU A  86
VAL A  39
 None
 1.26A 5hw4B-1b0aA:
undetectable		 5hw4B-1b0aA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jwa MOLYBDOPTERIN
BIOSYNTHESIS MOEB
PROTEIN

(Escherichia
coli) 		PF00899
(ThiF) 		5 ILE B 200
GLY B 152
ALA B 154
LEU B 196
VAL B 192
 None
 1.23A 5hw4B-1jwaB:
2.2		 5hw4B-1jwaB:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m64 FLAVOCYTOCHROME C3

(Shewanella
frigidimarina) 		PF00890
(FAD_binding_2)
PF14537
(Cytochrom_c3_2) 		5 ILE A 155
GLY A 278
ASP A 344
LEU A 154
GLU A 156
 None
FAD  A3000 (-3.8A)
FAD  A3000 (-3.4A)
None
FAD  A3000 (-2.7A)
 1.20A 5hw4B-1m64A:
undetectable		 5hw4B-1m64A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT

(Acidaminococcus
fermentans) 		PF01039
(Carboxyl_trans) 		5 ASP A 321
ALA A 362
LYS A 393
GLU A 337
VAL A 360
 None
 1.29A 5hw4B-1pixA:
undetectable		 5hw4B-1pixA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1puo MAJOR ALLERGEN I
POLYPEPTIDE, FUSED
CHAIN 2, CHAIN 1

(Felis catus) 		PF01099
(Uteroglobin)
PF09252
(Feld-I_B) 		5 ASP A 138
ALA A 130
TYR A 113
LEU A 127
VAL A 117
 None
 1.27A 5hw4B-1puoA:
undetectable		 5hw4B-1puoA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qs0 2-OXOISOVALERATE
DEHYDROGENASE
ALPHA-SUBUNIT
2-OXOISOVALERATE
DEHYDROGENASE
BETA-SUBUNIT

(Pseudomonas
putida;
Pseudomonas
putida) 		PF00676
(E1_dh)
PF12573
(OxoDH_E1alpha_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 GLY A 193
ALA B  69
TYR B  29
LEU B 115
VAL B  81
 None
 1.30A 5hw4B-1qs0A:
undetectable		 5hw4B-1qs0A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sg3 ALLANTOICASE

(Saccharomyces
cerevisiae) 		PF03561
(Allantoicase) 		5 ILE A  49
GLY A  32
LEU A  48
GLU A  46
VAL A  84
 None
 1.23A 5hw4B-1sg3A:
undetectable		 5hw4B-1sg3A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1su1 HYPOTHETICAL PROTEIN
YFCE

(Escherichia
coli) 		PF12850
(Metallophos_2) 		5 ILE A  34
GLY A  36
ALA A   7
LEU A  32
VAL A  20
 None
 1.21A 5hw4B-1su1A:
undetectable		 5hw4B-1su1A:
25.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tlt PUTATIVE
OXIDOREDUCTASE
(VIRULENCE FACTOR
MVIM HOMOLOG)

(Escherichia
coli) 		PF01408
(GFO_IDH_MocA) 		5 ILE A   8
GLY A   9
ALA A  68
LEU A   6
VAL A 279
 None
 1.19A 5hw4B-1tltA:
undetectable		 5hw4B-1tltA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE

(Escherichia
coli) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 ILE A  89
ALA A  65
PHE A  24
LEU A  62
VAL A   9
 None
 1.22A 5hw4B-1uagA:
1.9		 5hw4B-1uagA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wve 4-CRESOL
DEHYDROGENASE
[HYDROXYLATING]
FLAVOPROTEIN SUBUNIT

(Pseudomonas
putida) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		5 GLY A 469
ALA A 471
TYR A 487
LEU A 462
VAL A 483
 None
 1.20A 5hw4B-1wveA:
undetectable		 5hw4B-1wveA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x7p RRNA
METHYLTRANSFERASE

(Streptomyces
viridochromogenes) 		PF00588
(SpoU_methylase) 		5 ALA A 182
PHE A  41
TYR A 165
LEU A 155
VAL A 164
 None
 1.10A 5hw4B-1x7pA:
2.4		 5hw4B-1x7pA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xny PROPIONYL-COA
CARBOXYLASE COMPLEX
B SUBUNIT

(Streptomyces
coelicolor) 		PF01039
(Carboxyl_trans) 		5 ILE A 170
CYH A 133
ALA A 128
PHE A 102
LEU A 129
 None
 1.27A 5hw4B-1xnyA:
undetectable		 5hw4B-1xnyA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xx4 3,2-TRANS-ENOYL-COA
ISOMERASE,
MITOCHONDRIAL

(Rattus
norvegicus) 		PF00378
(ECH_1) 		5 ILE A  78
GLY A  80
ALA A  45
PHE A  65
VAL A  36
 None
 1.33A 5hw4B-1xx4A:
undetectable		 5hw4B-1xx4A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z8y SPIKE GLYCOPROTEIN
E1

(Sindbis virus) 		PF01589
(Alpha_E1_glycop) 		5 ILE A 214
GLY A 193
ALA A 215
LEU A 213
VAL A 108
 None
 1.26A 5hw4B-1z8yA:
undetectable		 5hw4B-1z8yA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zkr MAJOR ALLERGEN I
POLYPEPTIDE, FUSED
CHAIN 1, CHAIN 2

(Felis catus) 		PF01099
(Uteroglobin)
PF09252
(Feld-I_B) 		5 ASP A  46
ALA A  38
TYR A  21
LEU A  35
VAL A  25
 None
 1.28A 5hw4B-1zkrA:
undetectable		 5hw4B-1zkrA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4m GLYCOGEN
PHOSPHORYLASE

(Corynebacterium
callunae) 		PF00343
(Phosphorylase) 		5 ILE A 664
GLY A 644
ALA A 662
PHE A 771
VAL A 657
 None
 1.08A 5hw4B-2c4mA:
undetectable		 5hw4B-2c4mA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fvz INOSITOL
MONOPHOSPHATASE 2

(Homo sapiens) 		PF00459
(Inositol_P) 		5 ILE A 239
GLY A 244
ALA A 263
LEU A 211
VAL A 261
 None
 1.00A 5hw4B-2fvzA:
undetectable		 5hw4B-2fvzA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g4b SPLICING FACTOR U2AF
65 KDA SUBUNIT

(Homo sapiens) 		PF00076
(RRM_1) 		5 ILE A 156
GLY A 154
ALA A 198
PHE A 202
VAL A 189
 None
U  B   4 ( 4.0A)
None
None
None
 1.14A 5hw4B-2g4bA:
undetectable		 5hw4B-2g4bA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iai PUTATIVE
TRANSCRIPTIONAL
REGULATOR SCO3833

(Streptomyces
coelicolor) 		PF00440
(TetR_N) 		5 GLY A 112
ASP A  28
PHE A  22
GLU A  54
VAL A  61
 None
 1.27A 5hw4B-2iaiA:
undetectable		 5hw4B-2iaiA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A 171
GLY A 176
CYH A 177
ALA A 178
VAL A 147
 None
 1.35A 5hw4B-2iwiA:
undetectable		 5hw4B-2iwiA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jss CHIMERA OF HISTONE
H2B.1 AND HISTONE
H2A.Z
UNCHARACTERIZED
PROTEIN YER030W

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF00125
(Histone)
PF16211
(Histone_H2A_C)
PF09649
(CHZ) 		5 ILE A  62
ASP B  28
ALA A 129
GLU A  61
VAL A 125
 None
 1.30A 5hw4B-2jssA:
undetectable		 5hw4B-2jssA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p11 HYPOTHETICAL PROTEIN

(Paraburkholderia
xenovorans) 		no annotation 5 ILE A 214
GLY A 215
ALA A 100
LEU A  21
VAL A  96
 None
 1.07A 5hw4B-2p11A:
2.7		 5hw4B-2p11A:
27.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p5u UDP-GLUCOSE
4-EPIMERASE

(Thermus
thermophilus) 		PF01370
(Epimerase) 		5 GLY A 171
ALA A 120
TYR A 143
LEU A 275
GLU A 183
 None
None
NAD  A1118 (-4.4A)
None
None
 1.17A 5hw4B-2p5uA:
undetectable		 5hw4B-2p5uA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r5f TRANSCRIPTIONAL
REGULATOR, PUTATIVE

(Pseudomonas
syringae group
genomosp. 3) 		PF04198
(Sugar-bind) 		5 ILE A 277
ASP A 112
ALA A 209
LEU A 274
VAL A 211
 None
 1.24A 5hw4B-2r5fA:
undetectable		 5hw4B-2r5fA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2var FRUCTOKINASE

(Sulfolobus
solfataricus) 		PF00294
(PfkB) 		5 GLY A 293
ASP A 252
ALA A  33
TYR A  90
LEU A  37
 None
None
KDF  A1314 (-3.4A)
KDF  A1314 ( 4.0A)
None
 1.35A 5hw4B-2varA:
undetectable		 5hw4B-2varA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vp8 DIHYDROPTEROATE
SYNTHASE 2

(Mycobacterium
tuberculosis) 		PF00809
(Pterin_bind) 		5 ILE A 108
GLY A 137
ALA A 133
LEU A 104
VAL A 129
 None
 1.34A 5hw4B-2vp8A:
undetectable		 5hw4B-2vp8A:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x24 ACETYL-COA
CARBOXYLASE

(Bos taurus) 		PF01039
(Carboxyl_trans) 		5 ASP A 369
ALA A 423
LYS A 461
GLU A 398
VAL A 421
 None
 1.33A 5hw4B-2x24A:
undetectable		 5hw4B-2x24A:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x7x SENSOR PROTEIN

(Bacteroides
thetaiotaomicron) 		PF13407
(Peripla_BP_4) 		5 ILE A 114
GLY A 113
ALA A 109
LEU A  92
VAL A  81
 None
 1.34A 5hw4B-2x7xA:
2.2		 5hw4B-2x7xA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE EPSILON SUBUNIT

(Methanosarcina
barkeri) 		PF02552
(CO_dh) 		5 GLY G  69
ALA G  87
PHE G 119
TYR G 120
VAL G 124
 None
 1.24A 5hw4B-3cf4G:
3.7		 5hw4B-3cf4G:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d0k PUTATIVE
POLY(3-HYDROXYBUTYRA
TE) DEPOLYMERASE
LPQC

(Bordetella
parapertussis) 		no annotation 5 ILE A 266
GLY A 267
ALA A 272
PHE A 142
LEU A 295
 None
 1.32A 5hw4B-3d0kA:
undetectable		 5hw4B-3d0kA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3efm FERRIC ALCALIGIN
SIDEROPHORE RECEPTOR

(Bordetella
pertussis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 ILE A  80
GLY A  79
ASP A 522
ALA A  77
VAL A  57
 None
 1.25A 5hw4B-3efmA:
undetectable		 5hw4B-3efmA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fsx TETRAHYDRODIPICOLINA
TE
N-SUCCINYLTRANSFERAS
E

(Mycobacterium
tuberculosis) 		PF14602
(Hexapep_2)
PF14789
(THDPS_M) 		5 ILE A 248
GLY A 247
ALA A 278
LEU A 281
VAL A 276
 None
 1.29A 5hw4B-3fsxA:
undetectable		 5hw4B-3fsxA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gf7 GLUTACONYL-COA
DECARBOXYLASE
SUBUNIT A

([Clostridium]
symbiosum) 		PF01039
(Carboxyl_trans) 		5 ASP A 325
ALA A 366
LYS A 396
GLU A 341
VAL A 364
 None
 1.16A 5hw4B-3gf7A:
undetectable		 5hw4B-3gf7A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ief TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Bartonella
henselae) 		PF01746
(tRNA_m1G_MT) 		5 ASP A  79
ALA A   5
LEU A  35
GLU A  36
VAL A   7
 None
 1.16A 5hw4B-3iefA:
undetectable		 5hw4B-3iefA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ivr PUTATIVE
LONG-CHAIN-FATTY-ACI
D COA LIGASE

(Rhodopseudomonas
palustris) 		PF00501
(AMP-binding) 		5 ILE A  80
ASP A  52
ALA A  46
PHE A 144
LEU A  79
 None
 1.35A 5hw4B-3ivrA:
undetectable		 5hw4B-3ivrA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb5 MAJOR CAPSID PROTEIN

(Propionibacterium
virus PA6) 		no annotation 5 ILE A 167
GLY A 244
ALA A 299
LEU A 166
VAL A 150
 None
 1.25A 5hw4B-3jb5A:
undetectable		 5hw4B-3jb5A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4h PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Bacillus
cytotoxicus) 		PF13377
(Peripla_BP_3) 		5 ILE A  35
GLY A 251
ALA A 255
LEU A  11
VAL A 259
 None
 1.29A 5hw4B-3k4hA:
2.8		 5hw4B-3k4hA:
22.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kwp PREDICTED
METHYLTRANSFERASE

(Lactobacillus
brevis) 		PF00590
(TP_methylase) 		5 ILE A  22
GLY A  95
ALA A 125
LEU A 199
GLU A 226
 None
 0.86A 5hw4B-3kwpA:
28.9		 5hw4B-3kwpA:
42.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kwp PREDICTED
METHYLTRANSFERASE

(Lactobacillus
brevis) 		PF00590
(TP_methylase) 		8 ILE A  22
GLY A  95
ALA A 125
PHE A 145
TYR A 170
LEU A 199
LYS A 201
VAL A 228
 None
 0.53A 5hw4B-3kwpA:
28.9		 5hw4B-3kwpA:
42.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpe PUTATIVE
TRANSCRIPTION
ANTITERMINATION
PROTEIN NUSG
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
E''

(Methanocaldococcus
jannaschii;
Methanocaldococcus
jannaschii) 		PF03439
(Spt5-NGN)
PF06093
(Spt4) 		5 ILE B  32
GLY A  17
LYS B  50
GLU A  24
VAL A  30
 None
 1.33A 5hw4B-3lpeB:
undetectable		 5hw4B-3lpeB:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mru AMINOACYL-HISTIDINE
DIPEPTIDASE

(Vibrio
alginolyticus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 ILE A 235
GLY A 236
PHE A 316
LEU A 210
VAL A 270
 None
 0.98A 5hw4B-3mruA:
undetectable		 5hw4B-3mruA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzo LIN2634 PROTEIN

(Listeria
innocua) 		PF12917
(HD_2) 		5 ILE A 132
GLY A  45
ALA A  41
LEU A 133
VAL A  37
 None
 1.31A 5hw4B-3mzoA:
undetectable		 5hw4B-3mzoA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nnk UREIDOGLYCINE-GLYOXY
LATE
AMINOTRANSFERASE

(Klebsiella
pneumoniae) 		PF00266
(Aminotran_5) 		5 GLY A 147
ALA A 175
PHE A 171
LEU A 179
VAL A 194
 None
 1.20A 5hw4B-3nnkA:
1.8		 5hw4B-3nnkA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nv7 PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Helicobacter
pylori) 		PF01467
(CTP_transf_like) 		5 ILE A 135
GLY A 140
ALA A 142
TYR A 151
VAL A 146
 None
 1.09A 5hw4B-3nv7A:
undetectable		 5hw4B-3nv7A:
25.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppl ASPARTATE
AMINOTRANSFERASE

(Corynebacterium
glutamicum) 		PF12897
(Aminotran_MocR) 		5 ASP A  20
PHE A   9
LEU A 335
GLU A 337
VAL A 340
 None
 1.00A 5hw4B-3pplA:
undetectable		 5hw4B-3pplA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ry7 RIBOKINASE

(Staphylococcus
aureus) 		PF00294
(PfkB) 		5 ILE A  72
GLY A  39
ASP A  14
ALA A  69
LEU A  73
 None
None
GOL  A 401 (-3.1A)
None
None
 1.29A 5hw4B-3ry7A:
undetectable		 5hw4B-3ry7A:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sm9 METABOTROPIC
GLUTAMATE RECEPTOR 3

(Homo sapiens) 		PF01094
(ANF_receptor) 		5 ILE A  51
ALA A  50
PHE A 415
TYR A 373
VAL A 369
 None
 1.32A 5hw4B-3sm9A:
2.6		 5hw4B-3sm9A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ss6 ACETYL-COA
ACETYLTRANSFERASE

(Bacillus
anthracis) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 ILE A 169
ASP A 175
ALA A 320
LEU A 163
GLU A 161
 None
 1.07A 5hw4B-3ss6A:
undetectable		 5hw4B-3ss6A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqv NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE

(Francisella
tularensis) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		5 ILE A 185
ASP A 209
ALA A 214
PHE A 227
VAL A 222
 None
 1.23A 5hw4B-3tqvA:
undetectable		 5hw4B-3tqvA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr9 DIHYDROPTEROATE
SYNTHASE

(Coxiella
burnetii) 		PF00809
(Pterin_bind) 		5 ILE A  97
GLY A 125
ALA A 121
LEU A  93
VAL A 117
 None
 1.27A 5hw4B-3tr9A:
undetectable		 5hw4B-3tr9A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0b OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN

(Mycolicibacterium
smegmatis) 		PF13561
(adh_short_C2) 		5 ILE A 332
GLY A 336
PHE A 229
LEU A 326
VAL A 213
 None
 1.32A 5hw4B-3u0bA:
2.0		 5hw4B-3u0bA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4asi ACETYL-COA
CARBOXYLASE 1

(Homo sapiens) 		PF01039
(Carboxyl_trans) 		5 ASP A1970
ALA A2024
LYS A2062
GLU A1999
VAL A2022
 None
 1.29A 5hw4B-4asiA:
undetectable		 5hw4B-4asiA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cxk ARYLSULFATASE

(Pseudomonas
aeruginosa) 		PF00884
(Sulfatase) 		5 GLY A  70
ALA A  67
LEU A  90
GLU A  87
VAL A  94
 None
 1.26A 5hw4B-4cxkA:
undetectable		 5hw4B-4cxkA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g2r ACCD6,
CARBOXYLTRANSFERASE
BETA-SUBUNIT OF
ACYL-COA CARBOXYLASE

(Mycobacterium
tuberculosis) 		PF01039
(Carboxyl_trans) 		5 ASP A 243
ALA A 285
LYS A 302
GLU A 260
VAL A 283
 None
 1.29A 5hw4B-4g2rA:
undetectable		 5hw4B-4g2rA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g7e UREASE

(Cajanus cajan) 		PF00449
(Urease_alpha)
PF00547
(Urease_gamma)
PF00699
(Urease_beta)
PF01979
(Amidohydro_1) 		5 CYH B 237
ALA B 240
PHE B 182
GLU B 175
VAL B 244
 None
 1.26A 5hw4B-4g7eB:
undetectable		 5hw4B-4g7eB:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gbf PHIKZ131

(Pseudomonas
virus phiKZ) 		no annotation 5 GLY A 668
ASP A 716
ALA A 702
TYR A 696
VAL A 677
 None
 1.30A 5hw4B-4gbfA:
undetectable		 5hw4B-4gbfA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gi5 QUINONE REDUCTASE

(Klebsiella
pneumoniae) 		PF02525
(Flavodoxin_2) 		5 ILE A 172
GLY A 167
TYR A 195
LEU A 173
VAL A 193
 None
 1.24A 5hw4B-4gi5A:
undetectable		 5hw4B-4gi5A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpf POTASSIUM CHANNEL
SUBFAMILY U MEMBER 1

(Homo sapiens) 		PF03493
(BK_channel_a) 		5 ILE A 754
GLY A 755
CYH A 779
ALA A 780
LEU A 786
 None
 0.79A 5hw4B-4hpfA:
undetectable		 5hw4B-4hpfA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpf POTASSIUM CHANNEL
SUBFAMILY U MEMBER 1

(Homo sapiens) 		PF03493
(BK_channel_a) 		5 ILE A 754
GLY A 778
CYH A 779
ALA A 780
VAL A 799
 None
 1.23A 5hw4B-4hpfA:
undetectable		 5hw4B-4hpfA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iw7 8-AMINO-7-OXONONANOA
TE SYNTHASE

(Francisella
tularensis) 		PF00155
(Aminotran_1_2) 		5 ILE A  50
GLY A  53
ALA A 259
PHE A  92
LEU A  46
 None
 1.22A 5hw4B-4iw7A:
undetectable		 5hw4B-4iw7A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j1y COMPLEMENT C1S
SUBCOMPONENT

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		5 ILE A 548
ASP A 640
ALA A 649
LEU A 471
VAL A 668
 None
 1.31A 5hw4B-4j1yA:
undetectable		 5hw4B-4j1yA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jb3 HALOACID
DEHALOGENASE-LIKE
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF13419
(HAD_2) 		5 ILE A  16
GLY A  11
PHE A 123
LYS A  20
VAL A 114
 None
NA  A 301 ( 4.0A)
None
None
None
 1.21A 5hw4B-4jb3A:
undetectable		 5hw4B-4jb3A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1

(Physcomitrella
patens) 		PF01156
(IU_nuc_hydro) 		5 ILE A  34
ASP A  25
ALA A  64
LEU A  68
VAL A  78
 None
CA  A 400 (-2.9A)
None
None
None
 1.32A 5hw4B-4kpnA:
1.4		 5hw4B-4kpnA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ktb PUTATIVE
UNCHARACTERIZED
PROTEIN

(Jonesia
denitrificans) 		PF16262
(DUF4916) 		5 ILE A 166
CYH A 162
ALA A 161
LEU A  58
VAL A  56
 None
 1.16A 5hw4B-4ktbA:
undetectable		 5hw4B-4ktbA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l7a UNCHARACTERIZED
PROTEIN

(Bacteroides
caccae) 		PF15890
(Peptidase_Mx1) 		5 ILE A 255
GLY A 211
TYR A 186
LEU A 259
VAL A 262
 None
 1.03A 5hw4B-4l7aA:
undetectable		 5hw4B-4l7aA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mz0 CURL

(Moorea
producens) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 ILE A  71
GLY A 101
ALA A  70
PHE A  60
VAL A  68
 None
 1.19A 5hw4B-4mz0A:
undetectable		 5hw4B-4mz0A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4our PHYTOCHROME B

(Arabidopsis
thaliana) 		PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2) 		5 ILE B 131
GLY B 211
ASP B 209
ALA B 122
VAL B 334
 None
 1.28A 5hw4B-4ourB:
undetectable		 5hw4B-4ourB:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnh MOTILITY REGULATOR

(Pseudomonas
aeruginosa) 		PF00563
(EAL)
PF00990
(GGDEF) 		5 ILE A1263
GLY A1260
ASP A1256
LEU A1277
VAL A1247
 None
 1.29A 5hw4B-4rnhA:
undetectable		 5hw4B-4rnhA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tve NAUMOVOZYMA
DAIRENENSIS EPS1P

(Naumovozyma
dairenensis) 		PF00085
(Thioredoxin) 		5 ILE A  88
GLY A  83
ALA A 142
LEU A  52
VAL A 148
 None
 1.33A 5hw4B-4tveA:
undetectable		 5hw4B-4tveA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u1a ENOYL-COA DELTA
ISOMERASE 2

(Homo sapiens) 		PF00378
(ECH_1) 		5 ILE A 115
GLY A 114
ASP A 147
PHE A 199
LEU A 299
 None
 1.34A 5hw4B-4u1aA:
undetectable		 5hw4B-4u1aA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wli YUIC

(Bacillus
subtilis) 		PF06725
(3D) 		5 ILE A 156
GLY A 153
ALA A 127
TYR A  93
LEU A 161
 None
EDO  A 301 (-3.6A)
EDO  A 301 (-3.5A)
EDO  A 301 (-3.6A)
None
 1.16A 5hw4B-4wliA:
undetectable		 5hw4B-4wliA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yv7 PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR

(Mycolicibacterium
smegmatis) 		PF13407
(Peripla_BP_4) 		5 ILE A 122
GLY A 121
ALA A 117
LEU A 100
VAL A  89
 None
 1.33A 5hw4B-4yv7A:
3.8		 5hw4B-4yv7A:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yz6 TRANSCRIPTION FACTOR
MYC3

(Arabidopsis
thaliana) 		PF14215
(bHLH-MYC_N) 		5 GLY A 195
ALA A 192
PHE A 159
LEU A 178
GLU A 214
 None
 1.23A 5hw4B-4yz6A:
undetectable		 5hw4B-4yz6A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bym SUPPRESSOR PROTEIN
MPT5

(Saccharomyces
cerevisiae) 		PF00806
(PUF) 		5 ILE A 569
GLY A 566
PHE A 465
TYR A 531
VAL A 528
 None
 1.21A 5hw4B-5bymA:
undetectable		 5hw4B-5bymA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL

(Homo sapiens) 		PF00117
(GATase)
PF00988
(CPSase_sm_chain)
PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		5 ILE A 227
GLY A 226
CYH A 225
ALA A 262
GLU A 379
 None
EDO  A1606 ( 4.1A)
None
None
None
 1.31A 5hw4B-5dotA:
undetectable		 5hw4B-5dotA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqt PROTEASOME-ACTIVATIN
G NUCLEOTIDASE

(Pyrococcus
horikoshii) 		PF00004
(AAA) 		5 ILE A 211
GLY A 212
LEU A 176
GLU A 207
VAL A 171
 None
 1.33A 5hw4B-5eqtA:
undetectable		 5hw4B-5eqtA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5goo ALKALINE INVERTASE

(Nostoc sp. PCC
7120) 		PF12899
(Glyco_hydro_100) 		5 ILE A 160
ALA A 211
PHE A 204
LEU A 215
VAL A 228
 None
 1.33A 5hw4B-5gooA:
undetectable		 5hw4B-5gooA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gui CHAPERONE PROTEIN
CLPC1, CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF02861
(Clp_N) 		5 ILE A 131
ALA A 152
LEU A 127
GLU A 112
VAL A 156
 None
 1.35A 5hw4B-5guiA:
undetectable		 5hw4B-5guiA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzp TRIOSEPHOSPHATE
ISOMERASE

(Plasmodium
falciparum) 		PF00121
(TIM) 		5 ILE A  93
GLY A  94
PHE A   6
LEU A 113
VAL A 160
 None
 1.19A 5hw4B-5gzpA:
undetectable		 5hw4B-5gzpA:
21.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hw4 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I

(Escherichia
coli) 		PF00590
(TP_methylase) 		11 ILE A  21
GLY A  94
ASP A 100
CYH A 123
ALA A 124
PHE A 144
TYR A 169
LEU A 198
LYS A 200
GLU A 227
VAL A 229
 SAM  A 801 (-4.0A)
SAM  A 801 (-3.7A)
SAM  A 801 (-3.7A)
SAM  A 801 ( 3.7A)
SAM  A 801 (-3.3A)
SAM  A 801 (-4.7A)
SAM  A 801 (-3.5A)
SAM  A 801 (-3.8A)
SAM  A 801 ( 4.4A)
SAM  A 801 (-3.6A)
SAM  A 801 (-4.5A)
 0.21A 5hw4B-5hw4A:
34.6		 5hw4B-5hw4A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6g ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		5 ASP A1883
ALA A1934
LYS A1972
GLU A1909
VAL A1932
 None
 1.15A 5hw4B-5i6gA:
undetectable		 5hw4B-5i6gA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jay 8-AMINO-7-OXONONANOA
TE SYNTHASE

(Paraburkholderia
xenovorans) 		PF00155
(Aminotran_1_2) 		5 ILE A 289
GLY A 214
ASP A 209
ALA A 244
VAL A 282
 None
 1.35A 5hw4B-5jayA:
2.6		 5hw4B-5jayA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjp NONRIBOSOMAL PEPTIDE
SYNTHASE

(Streptomyces
sp. MJ635-86F5) 		PF00501
(AMP-binding) 		5 GLY A 421
CYH A 420
ALA A 409
LEU A 417
VAL A 350
 None
 1.34A 5hw4B-5jjpA:
2.4		 5hw4B-5jjpA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kck ANTHRANILATE
SYNTHASE COMPONENT I

(Streptococcus
pneumoniae) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		5 GLY A 386
ASP A  98
ALA A 389
GLU A 381
VAL A 365
 None
 1.24A 5hw4B-5kckA:
undetectable		 5hw4B-5kckA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l6s GLUCOSE-1-PHOSPHATE
ADENYLYLTRANSFERASE

(Escherichia
coli) 		PF00483
(NTP_transferase) 		5 ILE A  62
GLY A  65
CYH A  61
GLU A  97
VAL A  99
 None
 1.25A 5hw4B-5l6sA:
undetectable		 5hw4B-5l6sA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8i CUGBP ELAV-LIKE
FAMILY MEMBER 2

(Homo sapiens) 		no annotation 5 ILE A  45
GLY A  73
ALA A  58
LEU A  46
VAL A  55
 None
 1.21A 5hw4B-5m8iA:
undetectable		 5hw4B-5m8iA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mmi PLASTID RIBOSOMAL
PROTEIN UL5C

(Spinacia
oleracea) 		PF00281
(Ribosomal_L5)
PF00673
(Ribosomal_L5_C) 		5 ILE F 157
GLY F 227
PHE F 175
LEU F 156
VAL F 183
 None
 1.27A 5hw4B-5mmiF:
undetectable		 5hw4B-5mmiF:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mr6 XIAF PROTEIN

(Streptomyces
sp.) 		PF08028
(Acyl-CoA_dh_2) 		5 GLY A 116
ASP A 152
ALA A  53
LEU A  52
VAL A  89
 None
 1.16A 5hw4B-5mr6A:
undetectable		 5hw4B-5mr6A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5to3 PROTHROMBIN,THROMBOM
ODULIN

(Homo sapiens) 		PF00089
(Trypsin)
PF09064
(Tme5_EGF_like) 		5 GLY B 213
ALA B 215
PHE B 201
TYR B 255
VAL B 240
 None
0G6  B 501 (-3.4A)
None
None
None
 1.28A 5hw4B-5to3B:
undetectable		 5hw4B-5to3B:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u6u CYTOCHROME P450

(Rhodopseudomonas
palustris) 		no annotation 5 ILE A 145
ASP A 385
ALA A 147
LEU A 151
VAL A 261
 None
 1.31A 5hw4B-5u6uA:
undetectable		 5hw4B-5u6uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ulv MALATE DEHYDROGENASE

(Methylobacterium
extorquens) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ASP A  46
ALA A  19
TYR A  60
LEU A   8
VAL A  30
 None
 1.22A 5hw4B-5ulvA:
undetectable		 5hw4B-5ulvA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vyf CHIMERA OF MAJOR
ALLERGEN I
POLYPEPTIDE CHAIN
2,MAJOR ALLERGEN I
POLYPEPTIDE CHAIN 1

(Felis catus) 		no annotation 5 ASP F 138
ALA F 130
TYR F 113
LEU F 127
VAL F 117
 None
 1.24A 5hw4B-5vyfF:
undetectable		 5hw4B-5vyfF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w0g SPLICING FACTOR U2AF
65 KDA SUBUNIT

(Homo sapiens) 		no annotation 5 ILE A 156
GLY A 154
ALA A 198
PHE A 202
VAL A 189
 None
 1.10A 5hw4B-5w0gA:
undetectable		 5hw4B-5w0gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wox UNCHARACTERIZED
PROTEIN

(Mycolicibacterium
smegmatis) 		no annotation 5 GLY A  47
ASP A  25
ALA A  54
TYR A  41
LEU A  44
 None
 1.22A 5hw4B-5woxA:
undetectable		 5hw4B-5woxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjh POLY(ETHYLENE
TEREPHTHALATE)
HYDROLASE

(Ideonella
sakaiensis) 		no annotation 5 ILE A 109
GLY A  66
ASP A 112
ALA A 130
LEU A 131
 None
 1.21A 5hw4B-5xjhA:
undetectable		 5hw4B-5xjhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ane POLY(ETHYLENE
TEREPHTHALATE)
HYDROLASE

(Ideonella
sakaiensis) 		no annotation 5 ILE A  82
GLY A  39
ASP A  85
ALA A 103
LEU A 104
 None
 1.18A 5hw4B-6aneA:
undetectable		 5hw4B-6aneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ax6 PROCOLLAGEN LYSYL
HYDROXYLASE AND
GLYCOSYLTRANSFERASE

(Acanthamoeba
polyphaga
mimivirus) 		no annotation 5 ILE A 835
GLY A 864
ALA A 866
PHE A 715
LEU A 833
 None
 1.28A 5hw4B-6ax6A:
undetectable		 5hw4B-6ax6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfi VIN1

(Oscarella
pearsei) 		no annotation 5 ILE A 723
GLY A  22
ALA A 778
LEU A 722
GLU A  29
 None
 1.34A 5hw4B-6bfiA:
undetectable		 5hw4B-6bfiA:
undetectable