SIMILAR PATTERNS OF AMINO ACIDS FOR 5HW4_A_SAMA801_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1epx FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE

(Leishmania
mexicana) 		PF00274
(Glycolytic) 		5 ILE A  86
THR A 117
ASP A 118
CYH A 155
LEU A  39
 None
 0.95A 5hw4A-1epxA:
undetectable		 5hw4A-1epxA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE,
GLYCOSOMAL

(Trypanosoma
brucei) 		PF00274
(Glycolytic) 		5 ILE A  86
THR A 117
ASP A 118
CYH A 155
LEU A  39
 None
 0.97A 5hw4A-1f2jA:
undetectable		 5hw4A-1f2jA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hzf COMPLEMENT FACTOR
C4A

(Homo sapiens) 		PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl) 		5 THR A1286
ALA A1000
PHE A1125
LEU A 999
VAL A1066
 None
 1.13A 5hw4A-1hzfA:
undetectable		 5hw4A-1hzfA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m64 FLAVOCYTOCHROME C3

(Shewanella
frigidimarina) 		PF00890
(FAD_binding_2)
PF14537
(Cytochrom_c3_2) 		5 ILE A 155
GLY A 278
ASP A 344
LEU A 154
GLU A 156
 None
FAD  A3000 (-3.8A)
FAD  A3000 (-3.4A)
None
FAD  A3000 (-2.7A)
 1.24A 5hw4A-1m64A:
undetectable		 5hw4A-1m64A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ms8 TRANS-SIALIDASE

(Trypanosoma
cruzi) 		PF13385
(Laminin_G_3)
PF13859
(BNR_3) 		5 ILE A 627
GLY A 628
THR A 629
LEU A 620
VAL A 485
 None
 1.24A 5hw4A-1ms8A:
undetectable		 5hw4A-1ms8A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1puo MAJOR ALLERGEN I
POLYPEPTIDE, FUSED
CHAIN 2, CHAIN 1

(Felis catus) 		PF01099
(Uteroglobin)
PF09252
(Feld-I_B) 		5 ASP A 138
ALA A 130
TYR A 113
LEU A 127
VAL A 117
 None
 1.26A 5hw4A-1puoA:
undetectable		 5hw4A-1puoA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT

(Wolinella
succinogenes) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		5 ILE A  11
GLY A 236
THR A 235
ALA A 181
LEU A  34
 None
FAD  A1656 ( 4.5A)
FAD  A1656 (-3.8A)
FAD  A1656 (-3.8A)
None
 1.17A 5hw4A-1qlbA:
0.0		 5hw4A-1qlbA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qs0 2-OXOISOVALERATE
DEHYDROGENASE
BETA-SUBUNIT

(Pseudomonas
putida) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 GLY B  71
ALA B  69
PHE B  56
TYR B  29
VAL B  81
 None
 1.20A 5hw4A-1qs0B:
undetectable		 5hw4A-1qs0B:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sg3 ALLANTOICASE

(Saccharomyces
cerevisiae) 		PF03561
(Allantoicase) 		5 ILE A  49
GLY A  32
LEU A  48
GLU A  46
VAL A  84
 None
 1.17A 5hw4A-1sg3A:
undetectable		 5hw4A-1sg3A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1su1 HYPOTHETICAL PROTEIN
YFCE

(Escherichia
coli) 		PF12850
(Metallophos_2) 		5 ILE A  34
GLY A  36
ALA A   7
LEU A  32
VAL A  20
 None
 1.22A 5hw4A-1su1A:
0.8		 5hw4A-1su1A:
25.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE

(Escherichia
coli) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 ILE A  89
ALA A  65
PHE A  24
LEU A  62
VAL A   9
 None
 1.21A 5hw4A-1uagA:
3.2		 5hw4A-1uagA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v47 ATP SULFURYLASE

(Thermus
thermophilus) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		5 ILE A 190
GLY A 192
ASP A  13
GLU A 237
VAL A 244
 None
 1.03A 5hw4A-1v47A:
undetectable		 5hw4A-1v47A:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vm7 RIBOKINASE

(Thermotoga
maritima) 		PF00294
(PfkB) 		5 GLY A 269
THR A 270
ALA A 265
LEU A 256
GLU A 258
 None
 1.09A 5hw4A-1vm7A:
undetectable		 5hw4A-1vm7A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wve 4-CRESOL
DEHYDROGENASE
[HYDROXYLATING]
FLAVOPROTEIN SUBUNIT

(Pseudomonas
putida) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		5 GLY A 469
ALA A 471
TYR A 487
LEU A 462
VAL A 483
 None
 1.20A 5hw4A-1wveA:
undetectable		 5hw4A-1wveA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00348
(polyprenyl_synt) 		5 ILE A 192
GLY A 193
THR A 194
ASP A 195
VAL A 141
 None
 1.22A 5hw4A-1wy0A:
undetectable		 5hw4A-1wy0A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x7p RRNA
METHYLTRANSFERASE

(Streptomyces
viridochromogenes) 		PF00588
(SpoU_methylase) 		5 ALA A 182
PHE A  41
TYR A 165
LEU A 155
VAL A 164
 None
 1.08A 5hw4A-1x7pA:
2.1		 5hw4A-1x7pA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ywg GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Plasmodium
falciparum) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 ILE O   8
GLY O  10
THR O  99
LEU O   6
VAL O 327
 None
NAD  O 401 (-3.5A)
NAD  O 401 (-3.9A)
None
None
 1.15A 5hw4A-1ywgO:
undetectable		 5hw4A-1ywgO:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aa4 PUTATIVE
N-ACETYLMANNOSAMINE
KINASE

(Escherichia
coli) 		PF00480
(ROK) 		5 GLY A 240
THR A 128
TYR A 249
LEU A 268
VAL A 253
 None
 1.17A 5hw4A-2aa4A:
undetectable		 5hw4A-2aa4A:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4m GLYCOGEN
PHOSPHORYLASE

(Corynebacterium
callunae) 		PF00343
(Phosphorylase) 		5 ILE A 664
GLY A 644
ALA A 662
PHE A 771
VAL A 657
 None
 1.12A 5hw4A-2c4mA:
1.8		 5hw4A-2c4mA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fvz INOSITOL
MONOPHOSPHATASE 2

(Homo sapiens) 		PF00459
(Inositol_P) 		5 ILE A 239
GLY A 244
ALA A 263
LEU A 211
VAL A 261
 None
 1.00A 5hw4A-2fvzA:
undetectable		 5hw4A-2fvzA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g4b SPLICING FACTOR U2AF
65 KDA SUBUNIT

(Homo sapiens) 		PF00076
(RRM_1) 		5 ILE A 156
GLY A 154
ALA A 198
PHE A 202
VAL A 189
 None
U  B   4 ( 4.0A)
None
None
None
 1.16A 5hw4A-2g4bA:
undetectable		 5hw4A-2g4bA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i1y RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 ILE A 922
THR A 884
ALA A 962
LEU A 921
VAL A 953
 None
 1.26A 5hw4A-2i1yA:
2.9		 5hw4A-2i1yA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lfd DIIRON PROTEIN

(Escherichia
coli) 		no annotation 5 GLY A  14
ALA A  10
LEU A   7
GLU A  74
VAL A  50
 None
None
None
ZN  A 400 ( 2.4A)
None
 1.24A 5hw4A-2lfdA:
undetectable		 5hw4A-2lfdA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n03 PLECTIN

(Homo sapiens) 		PF00681
(Plectin) 		5 ILE A4535
GLY A4456
CYH A4454
PHE A4496
LEU A4534
 None
 1.16A 5hw4A-2n03A:
undetectable		 5hw4A-2n03A:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p11 HYPOTHETICAL PROTEIN

(Paraburkholderia
xenovorans) 		no annotation 5 ILE A 214
GLY A 215
ALA A 100
LEU A  21
VAL A  96
 None
 1.05A 5hw4A-2p11A:
2.3		 5hw4A-2p11A:
27.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2paa PHOSPHOGLYCERATE
KINASE, TESTIS
SPECIFIC

(Mus musculus) 		PF00162
(PGK) 		5 GLY A 383
THR A 384
ASP A 386
CYH A 379
ALA A 380
 None
 1.09A 5hw4A-2paaA:
2.5		 5hw4A-2paaA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q6d INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE

(Avian
coronavirus) 		PF05409
(Peptidase_C30) 		5 ILE A 252
THR A 199
LEU A 255
GLU A 295
VAL A 297
 None
 1.25A 5hw4A-2q6dA:
undetectable		 5hw4A-2q6dA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q6d INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE

(Avian
coronavirus) 		PF05409
(Peptidase_C30) 		5 THR A 199
ALA A 204
LEU A 255
GLU A 295
VAL A 297
 None
 1.19A 5hw4A-2q6dA:
undetectable		 5hw4A-2q6dA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cu2 RIBULOSE-5-PHOSPHATE
3-EPIMERASE

(Histophilus
somni) 		PF00834
(Ribul_P_3_epim) 		5 ILE A 148
GLY A 129
THR A  96
LEU A 145
VAL A 176
 None
 1.22A 5hw4A-3cu2A:
undetectable		 5hw4A-3cu2A:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3efm FERRIC ALCALIGIN
SIDEROPHORE RECEPTOR

(Bordetella
pertussis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 ILE A  80
GLY A  79
ASP A 522
ALA A  77
VAL A  57
 None
 1.19A 5hw4A-3efmA:
undetectable		 5hw4A-3efmA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gf7 GLUTACONYL-COA
DECARBOXYLASE
SUBUNIT A

([Clostridium]
symbiosum) 		PF01039
(Carboxyl_trans) 		5 ASP A 325
ALA A 366
LYS A 396
GLU A 341
VAL A 364
 None
 1.17A 5hw4A-3gf7A:
undetectable		 5hw4A-3gf7A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hps 2-ISOPROPYLMALATE
SYNTHASE

(Mycobacterium
tuberculosis) 		PF00682
(HMGL-like)
PF08502
(LeuA_dimer) 		5 GLY A 195
ALA A 192
PHE A 249
TYR A 215
VAL A 231
 None
 1.25A 5hw4A-3hpsA:
undetectable		 5hw4A-3hpsA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hpx 2-ISOPROPYLMALATE
SYNTHASE

(Mycobacterium
tuberculosis) 		PF00682
(HMGL-like) 		5 GLY A 195
ALA A 192
PHE A 249
TYR A 215
VAL A 231
 None
 1.24A 5hw4A-3hpxA:
undetectable		 5hw4A-3hpxA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6d PROTOPORPHYRINOGEN
OXIDASE

(Bacillus
subtilis) 		PF01593
(Amino_oxidase) 		5 GLY A 331
THR A 346
CYH A 345
LEU A  98
VAL A 394
 None
 1.05A 5hw4A-3i6dA:
undetectable		 5hw4A-3i6dA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6d PROTOPORPHYRINOGEN
OXIDASE

(Bacillus
subtilis) 		PF01593
(Amino_oxidase) 		5 ILE A  10
GLY A  17
THR A  16
ALA A  21
LEU A  37
 None
None
FAD  A 600 (-3.4A)
None
None
 1.18A 5hw4A-3i6dA:
undetectable		 5hw4A-3i6dA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ief TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Bartonella
henselae) 		PF01746
(tRNA_m1G_MT) 		5 ASP A  79
ALA A   5
LEU A  35
GLU A  36
VAL A   7
 None
 1.22A 5hw4A-3iefA:
2.8		 5hw4A-3iefA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kio RIBONUCLEASE H2
SUBUNIT A
RIBONUCLEASE H2
SUBUNIT C

(Mus musculus;
Mus musculus) 		PF01351
(RNase_HII)
PF08615
(RNase_H2_suC) 		5 GLY C  67
THR A 104
ALA C  61
PHE A 229
LEU C  59
 None
 1.21A 5hw4A-3kioC:
undetectable		 5hw4A-3kioC:
25.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kwp PREDICTED
METHYLTRANSFERASE

(Lactobacillus
brevis) 		PF00590
(TP_methylase) 		5 ILE A  22
GLY A  95
ALA A 125
LEU A 199
GLU A 226
 None
 0.83A 5hw4A-3kwpA:
28.8		 5hw4A-3kwpA:
42.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kwp PREDICTED
METHYLTRANSFERASE

(Lactobacillus
brevis) 		PF00590
(TP_methylase) 		8 ILE A  22
GLY A  95
ALA A 125
PHE A 145
TYR A 170
LEU A 199
LYS A 201
VAL A 228
 None
 0.54A 5hw4A-3kwpA:
28.8		 5hw4A-3kwpA:
42.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpe PUTATIVE
TRANSCRIPTION
ANTITERMINATION
PROTEIN NUSG
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
E''

(Methanocaldococcus
jannaschii;
Methanocaldococcus
jannaschii) 		PF03439
(Spt5-NGN)
PF06093
(Spt4) 		5 ILE B  32
GLY A  17
LYS B  50
GLU A  24
VAL A  30
 None
 1.24A 5hw4A-3lpeB:
undetectable		 5hw4A-3lpeB:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lzk FUMARYLACETOACETATE
HYDROLASE FAMILY
PROTEIN

(Sinorhizobium
meliloti) 		PF01557
(FAA_hydrolase) 		5 GLY A 140
THR A 264
ASP A 170
CYH A 286
LEU A 223
 None
None
CA  A 339 (-3.5A)
None
None
 1.25A 5hw4A-3lzkA:
undetectable		 5hw4A-3lzkA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mg0 PROTEASOME COMPONENT
PRE6

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		5 ILE C  70
ALA C  92
TYR C 115
LEU C  76
VAL C 116
 None
 1.21A 5hw4A-3mg0C:
undetectable		 5hw4A-3mg0C:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mru AMINOACYL-HISTIDINE
DIPEPTIDASE

(Vibrio
alginolyticus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 ILE A 235
GLY A 236
PHE A 316
LEU A 210
VAL A 270
 None
 0.94A 5hw4A-3mruA:
undetectable		 5hw4A-3mruA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nnk UREIDOGLYCINE-GLYOXY
LATE
AMINOTRANSFERASE

(Klebsiella
pneumoniae) 		PF00266
(Aminotran_5) 		5 GLY A 147
ALA A 175
PHE A 171
LEU A 179
VAL A 194
 None
 1.19A 5hw4A-3nnkA:
1.8		 5hw4A-3nnkA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3no5 UNCHARACTERIZED
PROTEIN

(Cupriavidus
pinatubonensis) 		PF05853
(BKACE) 		5 GLY A 203
THR A 202
CYH A 224
ALA A 214
LEU A 211
 None
 1.19A 5hw4A-3no5A:
undetectable		 5hw4A-3no5A:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nv7 PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Helicobacter
pylori) 		PF01467
(CTP_transf_like) 		5 ILE A 135
GLY A 140
ALA A 142
TYR A 151
VAL A 146
 None
 1.03A 5hw4A-3nv7A:
undetectable		 5hw4A-3nv7A:
25.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppl ASPARTATE
AMINOTRANSFERASE

(Corynebacterium
glutamicum) 		PF12897
(Aminotran_MocR) 		5 ASP A  20
PHE A   9
LEU A 335
GLU A 337
VAL A 340
 None
 1.04A 5hw4A-3pplA:
2.1		 5hw4A-3pplA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q58 N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE

(Salmonella
enterica) 		PF04131
(NanE) 		5 ILE A 150
GLY A 151
THR A 153
ALA A 131
PHE A 108
 None
 1.22A 5hw4A-3q58A:
undetectable		 5hw4A-3q58A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ss6 ACETYL-COA
ACETYLTRANSFERASE

(Bacillus
anthracis) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 ILE A 169
ASP A 175
ALA A 320
LEU A 163
GLU A 161
 None
 1.00A 5hw4A-3ss6A:
undetectable		 5hw4A-3ss6A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t8i PURINE NUCLEOSIDASE,
(IUNH-2)

(Sulfolobus
solfataricus) 		PF01156
(IU_nuc_hydro) 		5 ILE A 102
THR A 125
ASP A   7
ALA A 130
VAL A 137
 None
 1.21A 5hw4A-3t8iA:
undetectable		 5hw4A-3t8iA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr9 DIHYDROPTEROATE
SYNTHASE

(Coxiella
burnetii) 		PF00809
(Pterin_bind) 		5 ILE A  97
GLY A 125
ALA A 121
LEU A  93
VAL A 117
 None
 1.26A 5hw4A-3tr9A:
undetectable		 5hw4A-3tr9A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tva XYLOSE ISOMERASE
DOMAIN PROTEIN TIM
BARREL

(Planctopirus
limnophila) 		PF01261
(AP_endonuc_2) 		5 GLY A 191
THR A 190
ALA A 196
LEU A 197
VAL A 200
 None
 1.23A 5hw4A-3tvaA:
undetectable		 5hw4A-3tvaA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0f BETA-KETOACYL
SYNTHASE

(Brucella
abortus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 ILE A 100
GLY A  99
THR A  98
LEU A 144
VAL A 235
 None
 1.09A 5hw4A-3u0fA:
undetectable		 5hw4A-3u0fA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v5r PROTEIN GAL3

(Saccharomyces
cerevisiae) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		5 ILE A 324
GLY A 325
THR A 326
LEU A 400
VAL A 396
 None
 1.14A 5hw4A-3v5rA:
undetectable		 5hw4A-3v5rA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bev COPPER EFFLUX ATPASE

(Legionella
pneumophila) 		PF00122
(E1-E2_ATPase)
PF00702
(Hydrolase) 		5 GLY A 642
THR A 643
ALA A 640
LYS A 409
GLU A 650
 None
 1.16A 5hw4A-4bevA:
1.3		 5hw4A-4bevA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dws CHI2

(Yersinia
entomophaga) 		PF00704
(Glyco_hydro_18) 		5 ILE A 373
GLY A 415
PHE A 335
LEU A 372
VAL A 328
 None
 1.22A 5hw4A-4dwsA:
undetectable		 5hw4A-4dwsA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ft2 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Zea mays) 		PF00145
(DNA_methylase)
PF00385
(Chromo)
PF01426
(BAH) 		5 GLY A 352
THR A 355
ASP A 345
ALA A 858
GLU A 559
 SAH  A1000 (-3.9A)
None
SAH  A1000 ( 4.9A)
None
None
 1.19A 5hw4A-4ft2A:
undetectable		 5hw4A-4ft2A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gtn ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Acinetobacter
sp. ADP1) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		5 ILE A  30
ALA A  26
LEU A  61
GLU A  74
VAL A  44
 None
 1.13A 5hw4A-4gtnA:
undetectable		 5hw4A-4gtnA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h4g (3R)-HYDROXYMYRISTOY
L-[ACYL-CARRIER-PROT
EIN] DEHYDRATASE

(Burkholderia
thailandensis) 		PF07977
(FabA) 		5 ILE A  43
THR A  83
ALA A  78
LEU A 119
VAL A  31
 None
 1.20A 5hw4A-4h4gA:
undetectable		 5hw4A-4h4gA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpf POTASSIUM CHANNEL
SUBFAMILY U MEMBER 1

(Homo sapiens) 		PF03493
(BK_channel_a) 		5 ILE A 754
GLY A 755
CYH A 779
ALA A 780
LEU A 786
 None
 0.82A 5hw4A-4hpfA:
undetectable		 5hw4A-4hpfA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpf POTASSIUM CHANNEL
SUBFAMILY U MEMBER 1

(Homo sapiens) 		PF03493
(BK_channel_a) 		5 ILE A 754
GLY A 778
CYH A 779
ALA A 780
VAL A 799
 None
 1.25A 5hw4A-4hpfA:
undetectable		 5hw4A-4hpfA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iw7 8-AMINO-7-OXONONANOA
TE SYNTHASE

(Francisella
tularensis) 		PF00155
(Aminotran_1_2) 		5 ILE A  50
GLY A  53
ALA A 259
PHE A  92
LEU A  46
 None
 1.25A 5hw4A-4iw7A:
undetectable		 5hw4A-4iw7A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ixo NIFS-LIKE PROTEIN

(Rickettsia
africae) 		PF00266
(Aminotran_5) 		5 ILE A 197
GLY A 176
THR A 248
ALA A 243
VAL A  16
 LLP  A 196 ( 4.0A)
None
None
None
None
 1.13A 5hw4A-4ixoA:
1.5		 5hw4A-4ixoA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ktb PUTATIVE
UNCHARACTERIZED
PROTEIN

(Jonesia
denitrificans) 		PF16262
(DUF4916) 		5 ILE A 166
CYH A 162
ALA A 161
LEU A  58
VAL A  56
 None
 1.17A 5hw4A-4ktbA:
undetectable		 5hw4A-4ktbA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n3n EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN,
EIF5B(517-C)

(Chaetomium
thermophilum) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF11987
(IF-2) 		5 ILE A1038
GLY A1037
THR A1036
PHE A 992
VAL A1002
 None
 1.14A 5hw4A-4n3nA:
3.0		 5hw4A-4n3nA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oyd APOPTOSIS REGULATOR
BHRF1

(Human
gammaherpesvirus
4) 		PF00452
(Bcl-2) 		5 ILE A 144
GLY A 149
THR A 152
TYR A  50
LEU A 140
 None
 1.11A 5hw4A-4oydA:
undetectable		 5hw4A-4oydA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wli YUIC

(Bacillus
subtilis) 		PF06725
(3D) 		5 ILE A 156
GLY A 153
ALA A 127
TYR A  93
LEU A 161
 None
EDO  A 301 (-3.6A)
EDO  A 301 (-3.5A)
EDO  A 301 (-3.6A)
None
 1.14A 5hw4A-4wliA:
undetectable		 5hw4A-4wliA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wlk YUIC

(Bacillus
subtilis) 		PF06725
(3D) 		5 ILE A 156
GLY A 153
ALA A 127
TYR A  93
LEU A 161
 None
3QL  A 301 (-3.6A)
3QL  A 301 (-3.6A)
3QL  A 301 (-3.6A)
None
 1.17A 5hw4A-4wlkA:
undetectable		 5hw4A-4wlkA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yog 3C-LIKE PROTEINASE

(Tylonycteris
bat coronavirus
HKU4) 		PF05409
(Peptidase_C30) 		5 ILE A 251
THR A 204
ALA A 209
LEU A 254
VAL A 296
 None
 1.02A 5hw4A-4yogA:
undetectable		 5hw4A-4yogA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yz6 TRANSCRIPTION FACTOR
MYC3

(Arabidopsis
thaliana) 		PF14215
(bHLH-MYC_N) 		5 GLY A 195
ALA A 192
PHE A 159
LEU A 178
GLU A 214
 None
 1.24A 5hw4A-4yz6A:
undetectable		 5hw4A-4yz6A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zn1 TRANSCRIPTION
ELONGATION FACTOR
SPT5
TRANSCRIPTION
ELONGATION FACTOR
SPT4

(Methanocaldococcus
jannaschii;
Methanocaldococcus
jannaschii) 		PF00467
(KOW)
PF03439
(Spt5-NGN)
PF06093
(Spt4) 		5 ILE B  32
GLY A  17
LYS B  50
GLU A  24
VAL A  30
 None
 1.22A 5hw4A-4zn1B:
undetectable		 5hw4A-4zn1B:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpi PUTATIVE
OXIDASE/HYDROXYLASE

(Streptomyces
hygroscopicus) 		PF05721
(PhyH) 		5 THR A 220
ALA A 138
TYR A 224
LEU A 199
VAL A  75
 None
 1.20A 5hw4A-4zpiA:
undetectable		 5hw4A-4zpiA:
26.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5u EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT I

(Oryctolagus
cuniculus) 		PF00400
(WD40) 		5 GLY I 311
THR I 298
ALA I 309
PHE I 277
LEU I 319
 None
 1.20A 5hw4A-5a5uI:
undetectable		 5hw4A-5a5uI:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bym SUPPRESSOR PROTEIN
MPT5

(Saccharomyces
cerevisiae) 		PF00806
(PUF) 		5 ILE A 569
GLY A 566
PHE A 465
TYR A 531
VAL A 528
 None
 1.18A 5hw4A-5bymA:
undetectable		 5hw4A-5bymA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gqf LACTO-N-BIOSIDASE

(Bifidobacterium
longum) 		no annotation 5 ILE A 175
GLY A 213
THR A 212
LEU A 173
VAL A 170
 None
 1.15A 5hw4A-5gqfA:
undetectable		 5hw4A-5gqfA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hbt FAB35, HEAVY CHAIN

(Rattus
norvegicus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 GLY D  91
THR D  92
PHE D 153
LEU D  85
VAL D  12
 None
 1.26A 5hw4A-5hbtD:
undetectable		 5hw4A-5hbtD:
20.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hw4 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I

(Escherichia
coli) 		PF00590
(TP_methylase) 		12 ILE A  21
GLY A  94
THR A  95
ASP A 100
CYH A 123
ALA A 124
PHE A 144
TYR A 169
LEU A 198
LYS A 200
GLU A 227
VAL A 229
 SAM  A 801 (-4.0A)
SAM  A 801 (-3.7A)
SAM  A 801 (-4.4A)
SAM  A 801 (-3.7A)
SAM  A 801 ( 3.7A)
SAM  A 801 (-3.3A)
SAM  A 801 (-4.7A)
SAM  A 801 (-3.5A)
SAM  A 801 (-3.8A)
SAM  A 801 ( 4.4A)
SAM  A 801 (-3.6A)
SAM  A 801 (-4.5A)
 0.01A 5hw4A-5hw4A:
38.3		 5hw4A-5hw4A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5inf CARBOXYL TRANSFERASE

(Streptomyces
ambofaciens) 		PF01039
(Carboxyl_trans) 		5 ASP A 298
ALA A 339
LYS A 356
GLU A 314
VAL A 337
 None
 1.16A 5hw4A-5infA:
undetectable		 5hw4A-5infA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jtw COMPLEMENT C4-A

(Homo sapiens) 		PF00207
(A2M)
PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl) 		5 THR B1305
ALA B1019
PHE B1144
LEU B1018
VAL B1085
 None
 1.18A 5hw4A-5jtwB:
undetectable		 5hw4A-5jtwB:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jy9 PUTATIVE SALICYLATE
SYNTHETASE

(Yersinia
enterocolitica) 		PF00425
(Chorismate_bind) 		5 ILE A  53
GLY A  57
THR A  58
ALA A  60
LEU A  51
 None
 1.23A 5hw4A-5jy9A:
undetectable		 5hw4A-5jy9A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kwa PROTEASOME-ASSOCIATE
D ATPASE

(Mycobacterium
tuberculosis) 		PF00004
(AAA)
PF16450
(Prot_ATP_ID_OB) 		5 ILE A 519
GLY A 516
ALA A 445
TYR A 487
VAL A 483
 None
ADP  A 701 (-3.4A)
None
None
None
 1.20A 5hw4A-5kwaA:
2.3		 5hw4A-5kwaA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l6s GLUCOSE-1-PHOSPHATE
ADENYLYLTRANSFERASE

(Escherichia
coli) 		PF00483
(NTP_transferase) 		5 ILE A  62
GLY A  65
CYH A  61
GLU A  97
VAL A  99
 None
 1.22A 5hw4A-5l6sA:
undetectable		 5hw4A-5l6sA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8j DIVALENT METAL
CATION TRANSPORTER
MNTH

(Eremococcus
coleocola) 		PF01566
(Nramp) 		5 ILE A 122
GLY A 347
THR A 346
ALA A 236
GLU A 119
 None
 1.09A 5hw4A-5m8jA:
undetectable		 5hw4A-5m8jA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqz PUTATIVE
BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE

(Archaeoglobus
fulgidus) 		no annotation 5 ILE A 261
GLY A 262
ALA A 238
LEU A 235
VAL A 191
 None
 1.24A 5hw4A-5mqzA:
undetectable		 5hw4A-5mqzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mr6 XIAF PROTEIN

(Streptomyces
sp.) 		PF08028
(Acyl-CoA_dh_2) 		5 GLY A 116
ASP A 152
ALA A  53
LEU A  52
VAL A  89
 None
 1.11A 5hw4A-5mr6A:
undetectable		 5hw4A-5mr6A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6v AMYLOSUCRASE

(Neisseria
polysaccharea) 		no annotation 5 ILE A 468
GLY A 491
THR A 492
ALA A 451
LEU A 471
 None
 1.24A 5hw4A-5n6vA:
undetectable		 5hw4A-5n6vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0s GLUCOSYLCERAMIDASE

(Thermoanaerobacterium
xylanolyticum) 		PF04685
(DUF608)
PF12215
(Glyco_hydr_116N)
PF17168
(DUF5127) 		5 GLY A 503
ALA A 567
TYR A 538
LEU A 568
VAL A 539
 None
 1.21A 5hw4A-5o0sA:
undetectable		 5hw4A-5o0sA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u47 PENICILLIN BINDING
PROTEIN 2X

(Streptococcus
thermophilus) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF03793
(PASTA) 		5 GLY A 621
THR A 623
ASP A 625
ALA A 617
VAL A 298
 None
 1.22A 5hw4A-5u47A:
undetectable		 5hw4A-5u47A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vmb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Acinetobacter
baumannii) 		PF00464
(SHMT) 		5 ILE A 363
GLY A 364
THR A 365
LEU A 320
VAL A 308
 None
 1.14A 5hw4A-5vmbA:
undetectable		 5hw4A-5vmbA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vyf CHIMERA OF MAJOR
ALLERGEN I
POLYPEPTIDE CHAIN
2,MAJOR ALLERGEN I
POLYPEPTIDE CHAIN 1

(Felis catus) 		no annotation 5 ASP F 138
ALA F 130
TYR F 113
LEU F 127
VAL F 117
 None
 1.22A 5hw4A-5vyfF:
undetectable		 5hw4A-5vyfF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w0g SPLICING FACTOR U2AF
65 KDA SUBUNIT

(Homo sapiens) 		no annotation 5 ILE A 156
GLY A 154
ALA A 198
PHE A 202
VAL A 189
 None
 1.10A 5hw4A-5w0gA:
undetectable		 5hw4A-5w0gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w0s 60 KDA CHAPERONIN

(Escherichia
coli) 		PF00118
(Cpn60_TCP1) 		5 ILE A 162
GLY A 159
THR A 149
ASP A 155
ALA A 399
 None
 1.24A 5hw4A-5w0sA:
undetectable		 5hw4A-5w0sA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1u CARBOXYLIC ESTER
HYDROLASE

(Culex
quinquefasciatus) 		PF00135
(COesterase) 		5 ILE A 140
GLY A 114
THR A 115
LEU A 143
VAL A 264
 None
 1.13A 5hw4A-5w1uA:
undetectable		 5hw4A-5w1uA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wox UNCHARACTERIZED
PROTEIN

(Mycolicibacterium
smegmatis) 		no annotation 5 GLY A  47
ASP A  25
ALA A  54
TYR A  41
LEU A  44
 None
 1.23A 5hw4A-5woxA:
undetectable		 5hw4A-5woxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x2o TASTE RECEPTOR, TYPE
1, MEMBER 3

(Oryzias latipes) 		PF01094
(ANF_receptor) 		5 ILE B 317
GLY B 318
THR B 319
TYR B 309
VAL B 308
 None
 1.07A 5hw4A-5x2oB:
2.6		 5hw4A-5x2oB:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbj FLAGELLAR
HOOK-ASSOCIATED
PROTEIN FLGK

(Campylobacter
jejuni) 		no annotation 5 ILE A 272
THR A 168
ASP A 170
PHE A 256
LEU A 284
 None
 1.17A 5hw4A-5xbjA:
undetectable		 5hw4A-5xbjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjh POLY(ETHYLENE
TEREPHTHALATE)
HYDROLASE

(Ideonella
sakaiensis) 		no annotation 5 ILE A 109
GLY A  66
ASP A 112
ALA A 130
LEU A 131
 None
 1.23A 5hw4A-5xjhA:
undetectable		 5hw4A-5xjhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxu RIBOSOMAL PROTEIN
ES7

(Toxoplasma
gondii) 		PF01251
(Ribosomal_S7e) 		5 ILE H 133
THR H 174
PHE H 191
LEU H 130
VAL H 156
 None
 1.23A 5hw4A-5xxuH:
undetectable		 5hw4A-5xxuH:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ane POLY(ETHYLENE
TEREPHTHALATE)
HYDROLASE

(Ideonella
sakaiensis) 		no annotation 5 ILE A  82
GLY A  39
ASP A  85
ALA A 103
LEU A 104
 None
 1.21A 5hw4A-6aneA:
undetectable		 5hw4A-6aneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g72 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
7, MITOCHONDRIAL
NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
8, MITOCHONDRIAL

(Mus musculus;
Mus musculus) 		no annotation
no annotation 		5 GLY B 134
THR I 116
ALA B 130
LEU B 102
VAL B  98
 None
 1.18A 5hw4A-6g72B:
undetectable		 5hw4A-6g72B:
undetectable