SIMILAR PATTERNS OF AMINO ACIDS FOR 5HV1_A_RFPA902_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1coy CHOLESTEROL OXIDASE

(Brevibacterium
sterolicum) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 ALA A 282
VAL A 263
LEU A 307
LEU A  30
ILE A 501
 None
 1.11A 5hv1A-1coyA:
0.0		 5hv1A-1coyA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h65 CHLOROPLAST OUTER
ENVELOPE PROTEIN
OEP34

(Pisum sativum) 		PF04548
(AIG1) 		5 VAL A  56
PRO A  77
VAL A  65
LEU A 115
ILE A 145
 None
 1.15A 5hv1A-1h65A:
undetectable		 5hv1A-1h65A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jpu GLYCEROL
DEHYDROGENASE

(Geobacillus
stearothermophilus) 		PF00465
(Fe-ADH) 		5 VAL A 284
GLN A 285
ALA A 332
VAL A 350
SER A 183
 None
 0.98A 5hv1A-1jpuA:
undetectable		 5hv1A-1jpuA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jpu GLYCEROL
DEHYDROGENASE

(Geobacillus
stearothermophilus) 		PF00465
(Fe-ADH) 		5 VAL A 284
GLN A 285
VAL A 350
SER A 183
MET A 192
 None
 0.99A 5hv1A-1jpuA:
undetectable		 5hv1A-1jpuA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kae HISTIDINOL
DEHYDROGENASE

(Escherichia
coli) 		PF00815
(Histidinol_dh) 		5 VAL A 178
PRO A 148
ALA A 149
VAL A 157
LEU A 193
 None
 1.20A 5hv1A-1kaeA:
0.0		 5hv1A-1kaeA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l0q SURFACE LAYER
PROTEIN

(Methanosarcina
mazei) 		PF00801
(PKD)
PF10282
(Lactonase) 		5 VAL A  88
GLN A  87
PRO A  71
ALA A  72
VAL A  90
 None
 1.20A 5hv1A-1l0qA:
2.8		 5hv1A-1l0qA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT

(Acidaminococcus
fermentans) 		PF01039
(Carboxyl_trans) 		5 VAL A 409
GLN A 446
VAL A 358
SER A 442
LEU A  98
 None
 1.22A 5hv1A-1pixA:
0.0		 5hv1A-1pixA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rh1 COLICIN B

(Escherichia
coli) 		PF01024
(Colicin)
PF03515
(Cloacin) 		5 VAL A 268
ALA A 216
VAL A 270
LEU A  64
ILE A 138
 None
 1.17A 5hv1A-1rh1A:
0.0		 5hv1A-1rh1A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rh9 ENDO-BETA-MANNANASE

(Solanum
lycopersicum) 		PF00150
(Cellulase) 		5 TYR A 171
ALA A 224
VAL A 220
LEU A 179
ILE A 196
 None
 1.24A 5hv1A-1rh9A:
1.5		 5hv1A-1rh9A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6p PHENYLALANINE
AMMONIA-LYASE

(Rhodotorula
toruloides) 		PF00221
(Lyase_aromatic) 		5 ALA A 506
VAL A 418
SER A 175
LEU A 160
ILE A 221
 None
 0.94A 5hv1A-1t6pA:
0.0		 5hv1A-1t6pA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tki TITIN

(Homo sapiens) 		PF00069
(Pkinase) 		5 TYR A 152
PRO A 147
VAL A 128
LEU A 278
ILE A 290
 None
 1.21A 5hv1A-1tkiA:
undetectable		 5hv1A-1tkiA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1us8 DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE

(Pyrococcus
furiosus) 		no annotation 5 VAL B 769
ALA B 752
VAL B 767
LEU B 789
LEU B 812
 None
 1.07A 5hv1A-1us8B:
undetectable		 5hv1A-1us8B:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uvy MYOGLOBIN

(Paramecium
caudatum) 		PF01152
(Bac_globin) 		5 VAL A  99
ALA A  92
VAL A  94
LEU A  53
ILE A  23
 None
 1.16A 5hv1A-1uvyA:
undetectable		 5hv1A-1uvyA:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x87 UROCANASE PROTEIN

(Geobacillus
stearothermophilus) 		PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C) 		5 VAL A 500
ALA A  24
VAL A 434
LEU A 513
LEU A  70
 None
 1.21A 5hv1A-1x87A:
undetectable		 5hv1A-1x87A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y56 HYPOTHETICAL PROTEIN
PH1363

(Pyrococcus
horikoshii) 		PF07992
(Pyr_redox_2)
PF13510
(Fer2_4) 		5 VAL A 210
PRO A 116
ALA A 117
LEU A 334
ILE A 216
 None
ATP  A 801 (-3.3A)
ATP  A 801 (-3.4A)
None
None
 1.23A 5hv1A-1y56A:
undetectable		 5hv1A-1y56A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ylo HYPOTHETICAL PROTEIN
SF2450

(Shigella
flexneri) 		PF05343
(Peptidase_M42) 		5 PRO A 187
ALA A 188
VAL A  57
LEU A 258
ILE A 269
 None
 1.22A 5hv1A-1yloA:
undetectable		 5hv1A-1yloA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bdz MEXICAIN

(Jacaratia
mexicana) 		PF00112
(Peptidase_C1) 		5 VAL A 132
GLN A  68
ALA A 124
VAL A 130
LEU A  72
 None
E64  A 501 ( 4.8A)
None
None
None
 1.20A 5hv1A-2bdzA:
undetectable		 5hv1A-2bdzA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epg HYPOTHETICAL PROTEIN
TTHA1785

(Thermus
thermophilus) 		PF01139
(RtcB) 		5 ALA A 122
VAL A 311
LEU A 107
SER A 105
ILE A 234
 None
 1.23A 5hv1A-2epgA:
undetectable		 5hv1A-2epgA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fkn UROCANATE HYDRATASE

(Bacillus
subtilis) 		PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C) 		5 VAL A 501
ALA A  25
VAL A 435
LEU A 514
LEU A  71
 None
 1.20A 5hv1A-2fknA:
undetectable		 5hv1A-2fknA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r14 MORPHINONE REDUCTASE

(Pseudomonas
putida) 		PF00724
(Oxidored_FMN) 		5 VAL A 222
ALA A 187
VAL A 185
LEU A 269
ILE A 212
 None
 1.22A 5hv1A-2r14A:
undetectable		 5hv1A-2r14A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w8i PUTATIVE OUTER
MEMBRANE LIPOPROTEIN
WZA

(Escherichia
coli) 		PF02563
(Poly_export)
PF10531
(SLBB) 		5 GLN A 335
ALA A 281
VAL A 257
LEU A 318
ILE A  60
 None
 1.23A 5hv1A-2w8iA:
undetectable		 5hv1A-2w8iA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wbp L-ARGININE
BETA-HYDROXYLASE

(Streptomyces
vinaceus) 		PF02668
(TauD) 		5 VAL A 131
PRO A  54
VAL A 142
LEU A 355
SER A 344
 None
 1.16A 5hv1A-2wbpA:
undetectable		 5hv1A-2wbpA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzl PHOSPHOPROTEIN

(Mokola
lyssavirus) 		PF03012
(PP_M1) 		5 VAL A 239
PRO A 259
VAL A 206
LEU A 231
SER A 271
 None
 1.22A 5hv1A-2wzlA:
undetectable		 5hv1A-2wzlA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y2w ARABINOFURANOSIDASE

(Bifidobacterium
longum) 		PF06964
(Alpha-L-AF_C) 		5 PRO A 448
ALA A 447
VAL A  56
LEU A  63
LEU A 498
 None
 1.20A 5hv1A-2y2wA:
3.4		 5hv1A-2y2wA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2e LYSOZYME C, MILK
ISOZYME

(Canis lupus) 		PF00062
(Lys) 		5 ALA A 110
LEU A 120
SER A  24
LEU A  59
ILE A  92
 None
 1.23A 5hv1A-2z2eA:
undetectable		 5hv1A-2z2eA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE

(Homo sapiens) 		PF16113
(ECH_2) 		5 VAL A 178
VAL A 148
LEU A 184
LEU A 350
MET A 302
 HIU  A 502 (-4.6A)
None
None
QUE  A 501 (-4.6A)
None
 1.18A 5hv1A-3bptA:
undetectable		 5hv1A-3bptA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3drk OLIGOPEPTIDE-BINDING
PROTEIN OPPA

(Lactococcus
lactis) 		PF00496
(SBP_bac_5) 		5 TYR A 119
ALA A  98
VAL A  89
SER A 477
LEU A 146
 None
 1.03A 5hv1A-3drkA:
undetectable		 5hv1A-3drkA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dxx TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE

(Escherichia
coli) 		PF02390
(Methyltransf_4) 		5 VAL A 138
GLN A 139
ALA A 122
LEU A  78
SER A  77
 None
 1.23A 5hv1A-3dxxA:
undetectable		 5hv1A-3dxxA:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5s METHYLENETETRAHYDROF
OLATE--TRNA-(URACIL-
5-)-METHYLTRANSFERAS
E TRMFO

(Thermus
thermophilus) 		PF01134
(GIDA) 		5 PRO A  39
ALA A  40
VAL A  50
LEU A  11
SER A  14
 None
FAD  A 444 ( 4.1A)
None
FAD  A 444 (-4.2A)
None
 1.19A 5hv1A-3g5sA:
undetectable		 5hv1A-3g5sA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdi PROCESSING PROTEASE

(Bacillus
halodurans) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		5 VAL A 311
GLN A 315
ALA A 300
SER A 319
LEU A 142
 None
 1.17A 5hv1A-3hdiA:
undetectable		 5hv1A-3hdiA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kiz PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Cytophaga
hutchinsonii) 		PF02769
(AIRS_C) 		5 VAL A 216
ALA A 256
LEU A 221
SER A 228
ILE A  81
 None
 1.23A 5hv1A-3kizA:
undetectable		 5hv1A-3kizA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l8k DIHYDROLIPOYL
DEHYDROGENASE

(Sulfolobus
solfataricus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 VAL A 338
PRO A 312
ALA A 311
VAL A 340
ILE A 136
 None
 1.24A 5hv1A-3l8kA:
undetectable		 5hv1A-3l8kA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lmd GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Corynebacterium
glutamicum) 		PF00348
(polyprenyl_synt) 		5 ALA A 205
VAL A 102
LEU A 170
LEU A 341
ILE A 233
 None
 1.22A 5hv1A-3lmdA:
2.5		 5hv1A-3lmdA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nva CTP SYNTHASE

(Sulfolobus
solfataricus) 		PF00117
(GATase)
PF06418
(CTP_synth_N) 		5 VAL A 119
PRO A  43
ALA A  92
VAL A  95
ILE A 205
 None
 1.23A 5hv1A-3nvaA:
undetectable		 5hv1A-3nvaA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o1l FORMYLTETRAHYDROFOLA
TE DEFORMYLASE

(Pseudomonas
syringae group
genomosp. 3) 		PF00551
(Formyl_trans_N) 		5 ALA A 163
VAL A 158
LEU A 175
LEU A 268
ILE A 232
 None
 1.20A 5hv1A-3o1lA:
2.9		 5hv1A-3o1lA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o66 GLYCINE
BETAINE/CARNITINE/CH
OLINE ABC
TRANSPORTER

(Staphylococcus
aureus) 		PF04069
(OpuAC) 		5 VAL A  69
LEU A  40
SER A  45
LEU A 254
ILE A 265
 None
 1.17A 5hv1A-3o66A:
undetectable		 5hv1A-3o66A:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oam 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE

(Vibrio cholerae) 		PF02348
(CTP_transf_3) 		5 VAL A  58
GLN A  31
PRO A   8
ALA A   9
VAL A  54
 None
 1.15A 5hv1A-3oamA:
undetectable		 5hv1A-3oamA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ol2 SEMAPHORIN-4D

(Homo sapiens) 		PF00047
(ig)
PF01403
(Sema)
PF01437
(PSI) 		5 GLN A 465
PRO A 499
ALA A 498
VAL A 496
ILE A  30
 None
 1.20A 5hv1A-3ol2A:
undetectable		 5hv1A-3ol2A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pyg 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE

(Mycobacterium
tuberculosis) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 VAL A  38
ALA A 262
VAL A  14
LEU A 210
SER A 164
 None
 1.01A 5hv1A-3pygA:
undetectable		 5hv1A-3pygA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r3s OXIDOREDUCTASE

(Salmonella
enterica) 		PF13561
(adh_short_C2) 		5 GLN A 242
PRO A  24
ALA A  23
LEU A 196
ILE A  61
 None
None
None
None
NAD  A 300 (-3.7A)
 1.23A 5hv1A-3r3sA:
undetectable		 5hv1A-3r3sA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rj8 CARBOHYDRATE OXIDASE

(Microdochium
nivale) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 VAL A 165
VAL A 163
SER A  67
LEU A 450
ILE A 426
 None
None
FAD  A 501 (-3.4A)
None
None
 1.15A 5hv1A-3rj8A:
undetectable		 5hv1A-3rj8A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t3w ENOYL-COA HYDRATASE

(Mycolicibacterium
thermoresistibile) 		PF00378
(ECH_1) 		5 GLN A 190
ALA A 141
VAL A 197
LEU A 130
ILE A 176
 None
 1.24A 5hv1A-3t3wA:
undetectable		 5hv1A-3t3wA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tcr MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN

(Mycobacteroides
abscessus) 		PF00994
(MoCF_biosynth) 		5 VAL A  28
ALA A  99
VAL A  30
LEU A 107
ILE A 114
 None
 0.98A 5hv1A-3tcrA:
undetectable		 5hv1A-3tcrA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tcr MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN

(Mycobacteroides
abscessus) 		PF00994
(MoCF_biosynth) 		5 VAL A  28
PRO A 100
ALA A  99
VAL A  30
ILE A 114
 None
 1.21A 5hv1A-3tcrA:
undetectable		 5hv1A-3tcrA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsd INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Bacillus
anthracis) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 ALA A 295
VAL A 264
LEU A  40
ILE A  47
MET A 362
 None
None
None
None
XMP  A 500 ( 3.8A)
 1.06A 5hv1A-3tsdA:
2.0		 5hv1A-3tsdA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uyq CARBONIC ANHYDRASE 3

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 VAL A 217
ALA A 116
SER A 182
LEU A 228
ILE A  59
 None
 1.20A 5hv1A-3uyqA:
undetectable		 5hv1A-3uyqA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zcw KINESIN-LIKE PROTEIN
KIF11

(Homo sapiens) 		PF00225
(Kinesin) 		5 VAL A 210
VAL A 204
LEU A 172
LEU A  90
ILE A 101
 None
 1.24A 5hv1A-3zcwA:
undetectable		 5hv1A-3zcwA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4blp PACKAGING ENZYME P4

(Pseudomonas
phage phi13) 		PF11602
(NTPase_P4) 		5 VAL A 277
ALA A 255
VAL A 150
LEU A 235
LEU A 201
 None
 1.23A 5hv1A-4blpA:
undetectable		 5hv1A-4blpA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bma UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE

(Aspergillus
fumigatus) 		PF01704
(UDPGP) 		5 ALA A 302
SER A 368
LEU A 123
ILE A 270
MET A 265
 None
 1.15A 5hv1A-4bmaA:
undetectable		 5hv1A-4bmaA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fqd NIKO PROTEIN

(Streptomyces
tendae) 		PF00275
(EPSP_synthase) 		5 VAL A  41
ALA A  89
LEU A 228
LEU A  97
MET A 148
 None
 1.21A 5hv1A-4fqdA:
undetectable		 5hv1A-4fqdA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g56 HSL7 PROTEIN

(Xenopus laevis) 		PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C) 		5 VAL A 429
PRO A 366
LEU A 433
SER A 442
LEU A 397
 None
 1.11A 5hv1A-4g56A:
undetectable		 5hv1A-4g56A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4huj UNCHARACTERIZED
PROTEIN

(Sinorhizobium
meliloti) 		PF03807
(F420_oxidored) 		5 VAL A 113
LEU A 177
SER A 180
LEU A  16
ILE A 164
 None
 1.11A 5hv1A-4hujA:
undetectable		 5hv1A-4hujA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hyr GLUCARATE
DEHYDRATASE

(Acidaminococcus
intestini) 		PF13378
(MR_MLE_C) 		5 VAL A  67
VAL A  63
LEU A 109
ILE A 342
MET A 346
 None
 1.24A 5hv1A-4hyrA:
undetectable		 5hv1A-4hyrA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jin RIO-TYPE
SERINE/THREONINE-PRO
TEIN KINASE RIO1

(Archaeoglobus
fulgidus) 		PF01163
(RIO1) 		5 VAL A 134
ALA A 190
VAL A 132
LEU A 197
MET A  92
 None
 1.24A 5hv1A-4jinA:
4.1		 5hv1A-4jinA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 682
TYR A 695
PRO A 663
ALA A 662
LEU A 744
 None
 1.19A 5hv1A-4k33A:
2.3		 5hv1A-4k33A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lbw ELONGATION FACTOR
TU-A

(Thermus
thermophilus) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		5 GLN A  98
ALA A 102
VAL A 128
LEU A  31
ILE A  50
 None
 1.17A 5hv1A-4lbwA:
undetectable		 5hv1A-4lbwA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lr2 BIS(5'-ADENOSYL)-TRI
PHOSPHATASE ENPP4

(Homo sapiens) 		PF01663
(Phosphodiest) 		5 ALA A 132
VAL A 178
LEU A 378
LEU A 164
ILE A 234
 None
 1.23A 5hv1A-4lr2A:
undetectable		 5hv1A-4lr2A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9c BACTERIAL
TRANSFERASE
HEXAPEPTIDE (THREE
REPEATS) FAMILY
PROTEIN

(Acinetobacter
baumannii) 		PF00132
(Hexapep) 		5 VAL A  21
GLN A  24
ALA A  69
VAL A  17
LEU A  83
 None
 1.22A 5hv1A-4m9cA:
undetectable		 5hv1A-4m9cA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mgg MUCONATE LACTONIZING
ENZYME

(Labrenzia
aggregata) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ALA A 334
LEU A  13
SER A  33
LEU A 121
ILE A 266
 None
 1.18A 5hv1A-4mggA:
3.7		 5hv1A-4mggA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mx6 TRAP-TYPE
C4-DICARBOXYLATE:H+
SYMPORT SYSTEM
SUBSTRATE-BINDING
COMPONENT DCTP

(Shewanella
oneidensis) 		PF03480
(DctP) 		5 VAL A  72
ALA A 269
VAL A  62
LEU A 258
LEU A 154
 None
 1.15A 5hv1A-4mx6A:
undetectable		 5hv1A-4mx6A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ncj DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE

(Pyrococcus
furiosus) 		PF02463
(SMC_N) 		5 VAL A 769
ALA A 752
VAL A 767
LEU A 789
LEU A 812
 None
 1.14A 5hv1A-4ncjA:
undetectable		 5hv1A-4ncjA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p47 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Ochrobactrum
anthropi) 		PF03480
(DctP) 		5 VAL A  65
ALA A 263
VAL A  55
LEU A 252
ILE A 241
 None
 1.23A 5hv1A-4p47A:
undetectable		 5hv1A-4p47A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT D
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E

(Vibrio cholerae) 		PF02508
(Rnf-Nqr) 		5 VAL D 105
ALA D  80
VAL D  83
SER D  30
ILE E 122
 None
 1.16A 5hv1A-4p6vD:
2.6		 5hv1A-4p6vD:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj3 INTRON-BINDING
PROTEIN AQUARIUS

(Homo sapiens) 		PF13086
(AAA_11)
PF13087
(AAA_12)
PF16399
(Aquarius_N) 		5 VAL A1050
GLN A1079
LEU A 850
LEU A 466
ILE A 691
 None
 1.19A 5hv1A-4pj3A:
3.7		 5hv1A-4pj3A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qzv SPIKE PROTEIN S1

(Tylonycteris
bat coronavirus
HKU4) 		PF09408
(Spike_rec_bind) 		5 VAL B 118
GLN B 202
PRO B  28
ALA B  27
ILE B  90
 None
 1.20A 5hv1A-4qzvB:
undetectable		 5hv1A-4qzvB:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tnm IMPORTIN SUBUNIT
ALPHA

(Arabidopsis
thaliana) 		PF00514
(Arm)
PF01749
(IBB)
PF16186
(Arm_3) 		5 VAL A 315
ALA A 330
VAL A 325
LEU A 338
ILE A 374
 None
 0.94A 5hv1A-4tnmA:
undetectable		 5hv1A-4tnmA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tr4 TYPE III
IODOTHYRONINE
DEIODINASE

(Mus musculus) 		PF00837
(T4_deiodinase) 		5 VAL A 282
GLN A 281
ALA A 175
LEU A 232
ILE A 198
 None
 1.14A 5hv1A-4tr4A:
undetectable		 5hv1A-4tr4A:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tw0 SCAVENGER RECEPTOR
CLASS B MEMBER 2

(Homo sapiens) 		PF01130
(CD36) 		5 VAL A 389
PRO A 139
LEU A  76
LEU A 201
ILE A 133
 None
 1.15A 5hv1A-4tw0A:
undetectable		 5hv1A-4tw0A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4utt PUTATIVE
N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE

(Clostridium
perfringens) 		PF04131
(NanE) 		5 GLN A  14
ALA A  34
LEU A 189
ILE A 178
MET A 124
 CL  A1221 (-3.4A)
None
None
None
None
 1.19A 5hv1A-4uttA:
2.2		 5hv1A-4uttA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbt PROBABLE
HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Sinorhizobium
meliloti) 		PF00155
(Aminotran_1_2) 		5 VAL A 126
ALA A 110
VAL A 106
LEU A  10
SER A  13
 None
 1.22A 5hv1A-4wbtA:
undetectable		 5hv1A-4wbtA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wk5 GERANYLTRANSTRANSFER
ASE

(Thermotoga
neapolitana) 		PF00348
(polyprenyl_synt) 		5 PRO A 175
ALA A 174
LEU A 134
SER A  70
LEU A  43
 None
 1.15A 5hv1A-4wk5A:
undetectable		 5hv1A-4wk5A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wwv AMINOPEPTIDASE FROM
FAMILY M42

(Desulfurococcus
amylolyticus) 		PF05343
(Peptidase_M42) 		5 VAL A 187
PRO A 260
ALA A 343
VAL A 191
ILE A 299
 None
 1.07A 5hv1A-4wwvA:
undetectable		 5hv1A-4wwvA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhj ENVELOPE
GLYCOPROTEIN H

(Human
alphaherpesvirus
3) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C) 		5 VAL A 394
GLN A 397
ALA A 195
LEU A 425
SER A 423
 None
 1.21A 5hv1A-4xhjA:
1.0		 5hv1A-4xhjA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0x ANTIBODY HC26AM
LIGHT CHAIN VARIABLE
DOMAIN

(Homo sapiens) 		PF07686
(V-set) 		5 GLN A  78
TYR A  85
ALA A  18
VAL A  12
LEU A  47
 None
 1.24A 5hv1A-4z0xA:
undetectable		 5hv1A-4z0xA:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8d CARBOHYDRATE BINDING
FAMILY 6

(Ruminiclostridium
thermocellum) 		PF04616
(Glyco_hydro_43) 		5 VAL A 305
ALA A 274
VAL A 285
LEU A  83
LEU A 119
 None
GOL  A1340 (-3.0A)
None
None
None
 1.23A 5hv1A-5a8dA:
undetectable		 5hv1A-5a8dA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT DELTA

(Schizosaccharomyces
pombe) 		PF01008
(IF-2B) 		5 VAL G 442
ALA G 261
VAL G 444
SER G 362
MET G 333
 None
 1.05A 5hv1A-5b04G:
3.0		 5hv1A-5b04G:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B

(Homo sapiens) 		PF00233
(PDEase_I) 		5 ALA A 260
VAL A 235
LEU A 248
LEU A 208
ILE A 199
 None
 0.83A 5hv1A-5b25A:
1.7		 5hv1A-5b25A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp8 ENT-COPALYL
DIPHOSPHATE SYNTHASE

(Streptomyces
platensis) 		PF00432
(Prenyltrans)
PF13243
(SQHop_cyclase_C) 		5 PRO A 137
ALA A 136
VAL A  78
SER A 225
LEU A 177
 None
 1.19A 5hv1A-5bp8A:
2.6		 5hv1A-5bp8A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e6g DE NOVO DESIGNED
PROTEIN CA01

(synthetic
construct) 		no annotation 5 GLN A  18
PRO A 110
ALA A 111
LEU A  88
ILE A   8
 None
 1.03A 5hv1A-5e6gA:
undetectable		 5hv1A-5e6gA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5enz UDP-GLCNAC
2-EPIMERASE

(Staphylococcus
aureus) 		PF02350
(Epimerase_2) 		5 VAL A 265
PRO A  19
ALA A  18
VAL A  47
SER A 282
 UDP  A 401 (-3.7A)
None
None
None
UDP  A 401 (-2.7A)
 1.22A 5hv1A-5enzA:
undetectable		 5hv1A-5enzA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epg ALDEHYDE OXIDASE

(Homo sapiens) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 PRO A1011
ALA A1166
VAL A1188
SER A1256
ILE A 968
 None
 1.17A 5hv1A-5epgA:
undetectable		 5hv1A-5epgA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exe OXALATE
OXIDOREDUCTASE
SUBUNIT BETA

(Moorella
thermoacetica) 		PF02775
(TPP_enzyme_C) 		6 PRO C  12
ALA C  11
LEU C  31
LEU C   2
ILE C 105
MET C 107
 None
 1.46A 5hv1A-5exeC:
undetectable		 5hv1A-5exeC:
17.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fbu PHOSPHOENOLPYRUVATE
SYNTHASE

(Listeria
monocytogenes) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N) 		11 VAL A 333
TYR A 351
PRO A 356
ALA A 357
VAL A 368
LEU A 387
SER A 390
LEU A 478
ILE A 487
MET A 488
MET A 491
 5WP  A 901 (-3.6A)
5WP  A 901 (-4.5A)
5WP  A 901 (-4.3A)
5WP  A 901 ( 4.0A)
5WP  A 901 (-4.5A)
5WP  A 901 (-4.3A)
5WP  A 901 ( 3.7A)
5WP  A 901 (-4.7A)
None
5WP  A 901 (-4.2A)
5WP  A 901 (-3.6A)
 0.51A 5hv1A-5fbuA:
51.3		 5hv1A-5fbuA:
98.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fbu PHOSPHOENOLPYRUVATE
SYNTHASE

(Listeria
monocytogenes) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N) 		6 VAL A 333
TYR A 351
VAL A 368
LEU A 387
ILE A 484
MET A 488
 5WP  A 901 (-3.6A)
5WP  A 901 (-4.5A)
5WP  A 901 (-4.5A)
5WP  A 901 (-4.3A)
None
5WP  A 901 (-4.2A)
 1.06A 5hv1A-5fbuA:
51.3		 5hv1A-5fbuA:
98.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fbu PHOSPHOENOLPYRUVATE
SYNTHASE

(Listeria
monocytogenes) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N) 		6 VAL A 333
TYR A 351
VAL A 368
LEU A 387
LEU A 478
ILE A 484
 5WP  A 901 (-3.6A)
5WP  A 901 (-4.5A)
5WP  A 901 (-4.5A)
5WP  A 901 (-4.3A)
5WP  A 901 (-4.7A)
None
 1.32A 5hv1A-5fbuA:
51.3		 5hv1A-5fbuA:
98.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ghf AMINOTRANSFERASE
CLASS-III

(Ochrobactrum
anthropi) 		PF00202
(Aminotran_3) 		5 TYR A 240
PRO A 226
VAL A 234
LEU A 164
LEU A 255
 None
 1.24A 5hv1A-5ghfA:
undetectable		 5hv1A-5ghfA:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kre LYSOPHOSPHOLIPASE-LI
KE PROTEIN 1

(Homo sapiens) 		PF02230
(Abhydrolase_2) 		5 GLN A 139
ALA A 130
VAL A 144
LEU A 161
SER A 164
 None
 1.05A 5hv1A-5kreA:
undetectable		 5hv1A-5kreA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4L

(Bos taurus) 		PF00361
(Proton_antipo_M)
PF00420
(Oxidored_q2)
PF06444
(NADH_dehy_S2_C) 		5 PRO N 116
ALA N 180
LEU N 296
SER N 229
LEU K  95
 None
 1.10A 5hv1A-5lc5N:
undetectable		 5hv1A-5lc5N:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ld5 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Atopobium
vaginae) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 VAL A 328
PRO A 185
ALA A 184
SER A 332
ILE A 234
 None
 1.24A 5hv1A-5ld5A:
undetectable		 5hv1A-5ld5A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n1t FLAVIN-BINDING
SUBUNIT OF SULFIDE
DEHYDROGENASE

(Thioalkalivibrio
paradoxus) 		no annotation 5 VAL A 258
TYR A 148
ALA A 185
VAL A 255
MET A 176
 None
 1.19A 5hv1A-5n1tA:
undetectable		 5hv1A-5n1tA:
7.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n5d METHYLTRANSFERASE

(Streptomyces
regensis) 		PF01596
(Methyltransf_3) 		5 VAL A 164
ALA A 152
LEU A  75
SER A  71
LEU A 119
 None
None
None
SAM  A 306 (-2.2A)
None
 1.07A 5hv1A-5n5dA:
undetectable		 5hv1A-5n5dA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngo INACTIVE POLY
[ADP-RIBOSE]
POLYMERASE RCD1

(Arabidopsis
thaliana) 		PF00644
(PARP) 		5 VAL A 343
PRO A 334
ALA A 335
VAL A 339
LEU A 366
 None
 1.23A 5hv1A-5ngoA:
undetectable		 5hv1A-5ngoA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Homo sapiens) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		5 VAL A2701
PRO A2652
ALA A2651
VAL A2649
LEU A2661
 None
 1.16A 5hv1A-5nugA:
undetectable		 5hv1A-5nugA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oqp CONDENSIN COMPLEX
SUBUNIT 3

(Saccharomyces
cerevisiae) 		no annotation 5 ALA A 637
VAL A 674
LEU A 686
LEU A 628
ILE A 658
 None
 1.17A 5hv1A-5oqpA:
4.1		 5hv1A-5oqpA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uuw INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Bacillus
anthracis) 		PF00478
(IMPDH) 		5 ALA A 295
VAL A 264
LEU A  40
ILE A  47
MET A 362
 None
None
None
None
IMP  A 501 ( 3.7A)
 1.19A 5hv1A-5uuwA:
2.1		 5hv1A-5uuwA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vj1 MDCA

(Pseudomonas
aeruginosa) 		PF16957
(Mal_decarbox_Al) 		5 VAL A 309
PRO A 299
ALA A 300
VAL A 306
LEU A 257
 None
 1.06A 5hv1A-5vj1A:
5.2		 5hv1A-5vj1A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ww1 PULULLANASE

(Paenibacillus
barengoltzii) 		no annotation 5 VAL A 461
TYR A 629
ALA A 520
VAL A 438
SER A 485
 None
 1.16A 5hv1A-5ww1A:
undetectable		 5hv1A-5ww1A:
6.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6au1 PUTATIVE HEMIN
STORAGE PROTEIN

(Bordetella
bronchiseptica) 		no annotation 5 VAL A 601
ALA A 550
VAL A 553
LEU A 614
ILE A 322
 None
 1.18A 5hv1A-6au1A:
undetectable		 5hv1A-6au1A:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bq6 THERMOSPERMINE
SYNTHASE

(Medicago
truncatula) 		no annotation 5 VAL A 102
PRO A  91
ALA A  92
VAL A 174
LEU A 201
 None
 1.07A 5hv1A-6bq6A:
undetectable		 5hv1A-6bq6A:
7.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fml INO80

(Chaetomium
thermophilum) 		no annotation 5 VAL G1673
ALA G1662
VAL G1671
LEU G1565
ILE G1582
 None
 1.08A 5hv1A-6fmlG:
undetectable		 5hv1A-6fmlG:
7.28