SIMILAR PATTERNS OF AMINO ACIDS FOR 5HSW_A_ACTA501_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1abr ABRIN-A

(Abrus
precatorius) 		PF00652
(Ricin_B_lectin) 		4 SER B 116
SER B 117
SER B 118
SER B 213
 None
 1.35A 5hswA-1abrB:
0.0		 5hswA-1abrB:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b7g PROTEIN
(GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE)

(Sulfolobus
solfataricus) 		PF01113
(DapB_N)
PF02800
(Gp_dh_C) 		4 ARG O 135
SER O 118
SER O 199
SER O 138
 SO4  O 611 ( 4.1A)
None
None
SO4  O 601 ( 2.8A)
 1.20A 5hswA-1b7gO:
0.0		 5hswA-1b7gO:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ckr HEAT SHOCK SUBSTRATE
BINDING DOMAIN OF
HSC-70

(Rattus
norvegicus) 		PF00012
(HSP70) 		4 SER A 534
SER A 535
SER A 538
SER A 430
 None
 1.35A 5hswA-1ckrA:
undetectable		 5hswA-1ckrA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f2n CAPSID PROTEIN

(Rice yellow
mottle virus) 		PF00729
(Viral_coat) 		4 ARG A  68
SER A 207
SER A 208
SER A 148
 None
 1.12A 5hswA-1f2nA:
undetectable		 5hswA-1f2nA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gk2 HISTIDINE
AMMONIA-LYASE

(Pseudomonas
putida) 		PF00221
(Lyase_aromatic) 		4 SER A 263
SER A 264
SER A 267
SER A 458
 None
 1.49A 5hswA-1gk2A:
0.0		 5hswA-1gk2A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hg8 ENDOPOLYGALACTURONAS
E

(Fusarium
verticillioides) 		PF00295
(Glyco_hydro_28) 		4 SER A 219
SER A 197
SER A 196
SER A 245
 None
 1.41A 5hswA-1hg8A:
0.0		 5hswA-1hg8A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1it5 PHOSPHOLIPASE A2

(Streptomyces
violaceoruber) 		PF09056
(Phospholip_A2_3) 		4 SER A  18
SER A  19
SER A  16
SER A  11
 None
 1.06A 5hswA-1it5A:
0.3		 5hswA-1it5A:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kvk MEVALONATE KINASE

(Rattus
norvegicus) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 ARG A  36
SER A   9
SER A 378
SER A 208
 None
 1.39A 5hswA-1kvkA:
0.0		 5hswA-1kvkA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qjm LACTOFERRIN

(Equus caballus) 		PF00405
(Transferrin) 		4 SER A  12
SER A 184
SER A 185
SER A  42
 None
 1.50A 5hswA-1qjmA:
0.0		 5hswA-1qjmA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rz6 CYTOCHROME C
PEROXIDASE

(Marinobacter
hydrocarbonoclasticus) 		PF00034
(Cytochrom_C)
PF03150
(CCP_MauG) 		4 SER A  44
SER A  45
SER A  46
SER A 116
 CIT  A 502 (-4.7A)
None
None
CIT  A 502 (-3.5A)
 0.93A 5hswA-1rz6A:
undetectable		 5hswA-1rz6A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ux6 THROMBOSPONDIN-1

(Homo sapiens) 		PF02412
(TSP_3)
PF05735
(TSP_C) 		4 SER A1013
SER A1014
SER A1015
SER A 829
 None
 0.94A 5hswA-1ux6A:
undetectable		 5hswA-1ux6A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dmz INAD-LIKE PROTEIN

(Homo sapiens) 		PF00595
(PDZ) 		4 ARG A 104
SER A 110
SER A 108
SER A 109
 None
 1.36A 5hswA-2dmzA:
undetectable		 5hswA-2dmzA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Escherichia
coli) 		PF01019
(G_glu_transpept) 		4 ARG A 337
SER A 295
SER A 294
SER A 463
 None
 1.29A 5hswA-2e0wA:
undetectable		 5hswA-2e0wA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i76 HYPOTHETICAL PROTEIN

(Thermotoga
maritima) 		PF10728
(DUF2520) 		4 ARG A 100
SER A  92
SER A  91
SER A 152
 None
 1.17A 5hswA-2i76A:
undetectable		 5hswA-2i76A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ice COMPLEMENT C3 BETA
CHAIN

(Homo sapiens) 		PF01835
(A2M_N)
PF07703
(A2M_N_2) 		4 ARG A 522
SER A 628
SER A 627
SER A   5
 None
 1.16A 5hswA-2iceA:
undetectable		 5hswA-2iceA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j4l URIDYLATE KINASE

(Sulfolobus
solfataricus) 		PF00696
(AA_kinase) 		4 SER A 132
SER A 131
SER A 130
SER A 195
 None
 1.33A 5hswA-2j4lA:
undetectable		 5hswA-2j4lA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qck FLAVIN REDUCTASE
DOMAIN PROTEIN

(Arthrobacter
sp. FB24) 		PF01613
(Flavin_Reduct) 		4 ARG A  94
SER A  62
SER A  60
SER A  61
 None
 1.46A 5hswA-2qckA:
undetectable		 5hswA-2qckA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r3v MEVALONATE KINASE

(Homo sapiens) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 ARG A  36
SER A   9
SER A 378
SER A 208
 None
 1.34A 5hswA-2r3vA:
undetectable		 5hswA-2r3vA:
22.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2w45 ALKALINE EXONUCLEASE

(Human
gammaherpesvirus
4) 		PF01771
(Herpes_alk_exo) 		4 SER A 128
SER A 129
SER A 130
SER A 201
 None
 0.68A 5hswA-2w45A:
44.0		 5hswA-2w45A:
41.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzf GLUCOSYLTRANSFERASE

(Legionella
pneumophila) 		PF16849
(Glyco_transf_88) 		4 SER A 173
SER A 174
SER A 175
SER A 201
 None
 1.11A 5hswA-2wzfA:
undetectable		 5hswA-2wzfA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzg GLUCOSYLTRANSFERASE

(Legionella
pneumophila) 		PF16849
(Glyco_transf_88) 		4 SER A 173
SER A 174
SER A 175
SER A 201
 None
 0.97A 5hswA-2wzgA:
undetectable		 5hswA-2wzgA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhe UNC18

(Monosiga
brevicollis) 		PF00995
(Sec1) 		4 SER A 158
SER A 156
SER A 157
SER A 154
 None
 1.44A 5hswA-2xheA:
undetectable		 5hswA-2xheA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ymu WD-40 REPEAT PROTEIN

(Nostoc
punctiforme) 		PF00400
(WD40) 		4 ARG A 102
SER A 100
SER A  99
SER A 141
 None
 1.20A 5hswA-2ymuA:
undetectable		 5hswA-2ymuA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ymu WD-40 REPEAT PROTEIN

(Nostoc
punctiforme) 		PF00400
(WD40) 		4 ARG A 389
SER A 387
SER A 386
SER A 428
 None
 1.30A 5hswA-2ymuA:
undetectable		 5hswA-2ymuA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ymu WD-40 REPEAT PROTEIN

(Nostoc
punctiforme) 		PF00400
(WD40) 		4 ARG A 512
SER A 510
SER A 509
SER A 551
 None
 1.26A 5hswA-2ymuA:
undetectable		 5hswA-2ymuA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3els PRE-MRNA LEAKAGE
PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00498
(FHA) 		4 SER A 162
SER A 161
SER A 137
SER A 189
 None
 1.37A 5hswA-3elsA:
undetectable		 5hswA-3elsA:
16.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pov ORF 37

(Human
gammaherpesvirus
8) 		PF01771
(Herpes_alk_exo) 		4 SER A 144
SER A 145
SER A 146
SER A 219
 FMT  A 489 ( 4.6A)
FMT  A 489 (-2.5A)
None
None
 0.64A 5hswA-3povA:
53.5		 5hswA-3povA:
99.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qum FAB 5D5A5 HEAVY
CHAIN
PROSTATE-SPECIFIC
ANTIGEN

(Mus musculus;
Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set)
PF00089
(Trypsin) 		4 ARG P 107
SER B  30
SER B  53
SER B  28
 None
 1.28A 5hswA-3qumP:
undetectable		 5hswA-3qumP:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rmt 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE 1

(Bacillus
halodurans) 		PF00275
(EPSP_synthase) 		4 ARG A 392
SER A 239
SER A 238
SER A 419
 None
 1.40A 5hswA-3rmtA:
undetectable		 5hswA-3rmtA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rnr STAGE II SPORULATION
E FAMILY PROTEIN

(Thermanaerovibrio
acidaminovorans) 		PF07228
(SpoIIE) 		4 SER A 105
SER A 143
SER A  87
SER A 145
 None
 1.45A 5hswA-3rnrA:
undetectable		 5hswA-3rnrA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3shm CAPSID PROTEIN VP1

(Adeno-associated
dependoparvovirus
A) 		PF00740
(Parvo_coat) 		4 SER A 262
SER A 261
SER A 385
SER A 264
 None
 1.45A 5hswA-3shmA:
undetectable		 5hswA-3shmA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttb EIGHT-HEME NITRITE
REDUCTASE

(Thioalkalivibrio
paradoxus) 		PF02335
(Cytochrom_C552) 		4 ARG A 401
SER A 399
SER A  76
SER A  79
 None
 1.08A 5hswA-3ttbA:
undetectable		 5hswA-3ttbA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 SER A  74
SER A  95
SER A  96
SER A  71
 None
None
None
SO4  A 406 ( 4.4A)
 1.49A 5hswA-3tz6A:
undetectable		 5hswA-3tz6A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vyw MNMC2

(Aquifex
aeolicus) 		PF05430
(Methyltransf_30) 		4 ARG A 232
SER A 244
SER A 245
SER A 224
 None
 1.10A 5hswA-3vywA:
undetectable		 5hswA-3vywA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vyw MNMC2

(Aquifex
aeolicus) 		PF05430
(Methyltransf_30) 		4 ARG A 232
SER A 245
SER A 244
SER A 224
 None
 1.49A 5hswA-3vywA:
undetectable		 5hswA-3vywA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wb1 UNCHARACTERIZED
PROTEIN MJ0488

(Methanocaldococcus
jannaschii) 		PF11576
(DUF3236) 		4 ARG A 102
SER A 112
SER A 129
SER A 127
 SO4  A 203 (-4.6A)
SO4  A 203 (-3.4A)
None
None
 1.25A 5hswA-3wb1A:
undetectable		 5hswA-3wb1A:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wky PROPHENOLOXIDASE B

(Marsupenaeus
japonicus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 SER A 556
SER A 616
SER A 573
SER A 552
 None
 1.28A 5hswA-3wkyA:
undetectable		 5hswA-3wkyA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wky PROPHENOLOXIDASE B

(Marsupenaeus
japonicus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 SER A 556
SER A 616
SER A 573
SER A 553
 None
 1.25A 5hswA-3wkyA:
undetectable		 5hswA-3wkyA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wmy EXTRACELLULAR
EXO-ALPHA-L-ARABINOF
URANOSIDASE

(Streptomyces
coelicolor) 		PF03664
(Glyco_hydro_62) 		4 SER A 220
SER A 219
SER A 223
SER A 463
 None
 1.26A 5hswA-3wmyA:
undetectable		 5hswA-3wmyA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wst PROTEIN ARGININE
N-METHYLTRANSFERASE
7

(Caenorhabditis
elegans) 		PF13649
(Methyltransf_25) 		4 SER A 572
SER A 570
SER A 571
SER A 623
 None
 1.37A 5hswA-3wstA:
undetectable		 5hswA-3wstA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF16417
(CNOT1_TTP_bind)
PF16418
(CNOT1_HEAT)
PF16419
(CNOT1_HEAT_N) 		4 ARG A 397
SER A 351
SER A 348
SER A 296
 None
 1.48A 5hswA-4b8bA:
undetectable		 5hswA-4b8bA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bi3 SSP1

(Serratia
marcescens) 		PF14113
(Tae4) 		4 SER A  15
SER A  14
SER A 148
SER A  18
 K  A1167 ( 3.2A)
None
K  A1167 (-4.3A)
None
 1.19A 5hswA-4bi3A:
undetectable		 5hswA-4bi3A:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bj8 ZEBAVIDIN

(Danio rerio) 		PF01382
(Avidin) 		4 ARG A 113
SER A 100
SER A  74
SER A  76
 None
BTN  A1123 ( 4.8A)
BTN  A1123 (-2.5A)
BTN  A1123 (-3.3A)
 1.27A 5hswA-4bj8A:
undetectable		 5hswA-4bj8A:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bms ALCLOHOL
DEHYDROGENASE/SHORT-
CHAIN DEHYDROGENASE

(Ralstonia sp.
DSMZ 6428) 		PF13561
(adh_short_C2) 		4 SER A 136
SER A 137
SER A 179
SER A 151
 None
NAP  A1250 (-3.1A)
None
None
 1.27A 5hswA-4bmsA:
undetectable		 5hswA-4bmsA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bqq INTEGRASE

(Streptomyces
virus phiC31) 		PF00239
(Resolvase) 		4 ARG A  13
SER A  95
SER A  92
SER A  12
 None
 1.46A 5hswA-4bqqA:
undetectable		 5hswA-4bqqA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dgq NON-HEME
CHLOROPEROXIDASE

(Burkholderia
cenocepacia) 		PF00561
(Abhydrolase_1) 		4 ARG A  62
SER A  34
SER A  35
SER A  63
 None
 1.35A 5hswA-4dgqA:
undetectable		 5hswA-4dgqA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 SER A 278
SER A 253
SER A 277
SER A 231
 NAG  A 804 ( 4.1A)
NAG  A 803 (-2.3A)
NAG  A 803 (-3.1A)
NAG  A 803 ( 4.5A)
 1.44A 5hswA-4m7eA:
undetectable		 5hswA-4m7eA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 ARG A 707
SER A 731
SER A 730
SER A 681
 NAG  A 903 (-3.8A)
None
None
NAG  A 903 (-2.5A)
 1.11A 5hswA-4mn8A:
undetectable		 5hswA-4mn8A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4plj 8G12 HEAVY CHAIN

(Mus musculus) 		no annotation 4 SER H  74
SER H  75
SER H  76
SER H  23
 None
 1.38A 5hswA-4pljH:
undetectable		 5hswA-4pljH:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ

(Escherichia
coli) 		PF00588
(SpoU_methylase) 		4 ARG A  82
SER A 141
SER A 142
SER A  80
 None
None
SAH  A 301 (-3.4A)
SAH  A 301 (-3.2A)
 1.20A 5hswA-4xboA:
undetectable		 5hswA-4xboA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0b ANTIBODY HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 SER H 192
SER H 193
SER H 194
SER H 142
 None
 0.88A 5hswA-4z0bH:
undetectable		 5hswA-4z0bH:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d5p HCGB

(Methanococcus
maripaludis) 		PF11576
(DUF3236) 		4 ARG A 101
SER A 111
SER A 128
SER A 126
 None
 1.39A 5hswA-5d5pA:
undetectable		 5hswA-5d5pA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dgt BENZOYLFORMATE
DECARBOXYLASE

(Pseudomonas
putida) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 SER A 180
SER A 181
SER A 182
SER A 147
 None
 1.01A 5hswA-5dgtA:
undetectable		 5hswA-5dgtA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ec1 ANTIBODY FAB
FRAGMENT LIGHT CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ARG B  18
SER B  74
SER B  63
SER B  77
 None
 1.02A 5hswA-5ec1B:
undetectable		 5hswA-5ec1B:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gs2 ANTI-MBP

(Homo sapiens) 		PF07686
(V-set) 		4 SER H  52
SER H  53
SER H  54
SER H  32
 None
 0.95A 5hswA-5gs2H:
undetectable		 5hswA-5gs2H:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08771
(FRB_dom)
PF11865
(DUF3385) 		4 SER A 920
SER A 922
SER A 923
SER A1582
 None
 1.40A 5hswA-5h64A:
undetectable		 5hswA-5h64A:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdq FAB HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 SER H 162
SER H 160
SER H 161
SER H 158
 None
 1.39A 5hswA-5hdqH:
undetectable		 5hswA-5hdqH:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k47 POLYCYSTIN-2

(Homo sapiens) 		PF08016
(PKD_channel) 		4 SER A 351
SER A 352
SER A 349
SER A 330
 None
 1.46A 5hswA-5k47A:
undetectable		 5hswA-5k47A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l6q H5AL

(Homo sapiens) 		PF07686
(V-set) 		4 ARG A  18
SER A  70
SER A  63
SER A  61
 None
 1.47A 5hswA-5l6qA:
undetectable		 5hswA-5l6qA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkf POLYCYSTIN-2

(Homo sapiens) 		PF08016
(PKD_channel) 		4 SER A 351
SER A 352
SER A 349
SER A 330
 None
 1.47A 5hswA-5mkfA:
undetectable		 5hswA-5mkfA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5pep PEPSIN

(Sus scrofa) 		PF00026
(Asp) 		4 SER A 251
SER A 252
SER A 249
SER A 255
 None
 1.48A 5hswA-5pepA:
undetectable		 5hswA-5pepA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uao TRYPTOPHANE-5-HALOGE
NASE

(Microbispora
sp. ATCC
PTA-5024) 		PF04820
(Trp_halogenase) 		4 ARG A 398
SER A 253
SER A 252
SER A 330
 None
 1.40A 5hswA-5uaoA:
undetectable		 5hswA-5uaoA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uhy ZV67 FAB CHAIN 2

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 SER H  75
SER H  76
SER H  77
SER H  25
 None
 1.31A 5hswA-5uhyH:
undetectable		 5hswA-5uhyH:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vn2 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE

(Brucella
melitensis) 		PF13561
(adh_short_C2) 		4 SER A 147
SER A 148
SER A 145
SER A 161
 ACT  A 302 (-3.3A)
None
ACT  A 302 ( 2.6A)
None
 1.11A 5hswA-5vn2A:
undetectable		 5hswA-5vn2A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtg 2,3-DIHYDROXY-2,3-DI
HYDROPHENYLPROPIONAT
E DEHYDROGENASE

(Pseudomonas sp.
MC1) 		PF13561
(adh_short_C2) 		4 SER B 142
SER B 143
SER B 140
SER B 156
 NAD  B 301 ( 4.8A)
None
NAD  B 301 (-2.1A)
None
 1.08A 5hswA-5xtgB:
undetectable		 5hswA-5xtgB:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yew MITOFUSIN-1,MITOFUSI
N-1 FUSION PROTEIN

(Homo sapiens) 		no annotation 4 SER B  90
SER B  89
SER B 103
SER B  85
 GDP  B 801 (-2.5A)
MG  B 804 ( 2.1A)
GDP  B 801 (-4.5A)
K  B 803 ( 2.9A)
 1.44A 5hswA-5yewB:
2.3		 5hswA-5yewB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ykb TREHALOSE SYNTHASE

(Deinococcus
radiodurans) 		no annotation 4 SER A 109
SER A 108
SER A 176
SER A  59
 None
 1.50A 5hswA-5ykbA:
undetectable		 5hswA-5ykbA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7mdh PROTEIN (MALATE
DEHYDROGENASE)

(Sorghum bicolor) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 ARG A 204
SER A 283
SER A 280
SER A 287
 None
 1.41A 5hswA-7mdhA:
undetectable		 5hswA-7mdhA:
22.16