SIMILAR PATTERNS OF AMINO ACIDS FOR 5HS6_A_J3ZA302

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bev BOVINE ENTEROVIRUS
COAT PROTEINS VP1 TO
VP4

(Enterovirus E) 		PF00073
(Rhv) 		4 HIS 2 172
LEU 2 125
LEU 2 123
THR 2 121
 None
 1.08A 5hs6A-1bev2:
undetectable		 5hs6A-1bev2:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hu8 CELLULAR TUMOR
ANTIGEN P53

(Mus musculus) 		PF00870
(P53) 		4 TYR A 231
LEU A 142
LEU A 108
THR A  99
 None
 1.12A 5hs6A-1hu8A:
undetectable		 5hs6A-1hu8A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfi PHOSPHOGLUCOMUTASE 1

(Paramecium
tetraurelia) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 HIS A 401
LEU A 212
LEU A 216
THR A 416
 None
 0.97A 5hs6A-1kfiA:
undetectable		 5hs6A-1kfiA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n21 (+)-BORNYL
DIPHOSPHATE SYNTHASE

(Salvia
officinalis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 HIS A 111
TYR A 115
LEU A 159
LEU A 155
 None
 1.02A 5hs6A-1n21A:
undetectable		 5hs6A-1n21A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5m PROSTAGLANDIN-E2
9-REDUCTASE

(Oryctolagus
cuniculus) 		PF00248
(Aldo_ket_red) 		4 TYR A  81
LEU A 103
LEU A  99
MET A 151
 None
 1.18A 5hs6A-1q5mA:
undetectable		 5hs6A-1q5mA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Escherichia
coli) 		PF00311
(PEPcase) 		4 HIS A 579
GLN A 561
LEU A 608
LEU A 596
 None
 0.97A 5hs6A-1qb4A:
undetectable		 5hs6A-1qb4A:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s2n EXTRACELLULAR
SUBTILISIN-LIKE
SERINE PROTEINASE

(Vibrio sp.
PA-44) 		PF00082
(Peptidase_S8) 		4 TYR A 233
LEU A 269
LEU A 197
THR A 265
 None
 1.12A 5hs6A-1s2nA:
4.4		 5hs6A-1s2nA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t0i YLR011WP

(Saccharomyces
cerevisiae) 		PF03358
(FMN_red) 		4 TYR A 124
LEU A 162
LEU A 170
THR A  26
 FMN  A 200 (-4.6A)
None
None
None
 1.13A 5hs6A-1t0iA:
6.0		 5hs6A-1t0iA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1we5 PUTATIVE FAMILY 31
GLUCOSIDASE YICI

(Escherichia
coli) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		4 GLN A 757
LEU A 669
LEU A 671
THR A 735
 None
 1.16A 5hs6A-1we5A:
undetectable		 5hs6A-1we5A:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wls L-ASPARAGINASE

(Pyrococcus
horikoshii) 		PF00710
(Asparaginase) 		4 LEU A  63
TRP A  60
LEU A  93
THR A 297
 None
 1.19A 5hs6A-1wlsA:
undetectable		 5hs6A-1wlsA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wvc GLUCOSE-1-PHOSPHATE
CYTIDYLYLTRANSFERASE

(Salmonella
enterica) 		PF00483
(NTP_transferase) 		4 HIS A 228
LEU A 136
MET A  42
THR A 257
 None
 1.17A 5hs6A-1wvcA:
2.4		 5hs6A-1wvcA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xi8 MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN

(Pyrococcus
furiosus) 		PF00994
(MoCF_biosynth)
PF03453
(MoeA_N)
PF03454
(MoeA_C) 		4 HIS A 313
LEU A  18
LEU A  14
THR A 279
 None
 1.03A 5hs6A-1xi8A:
undetectable		 5hs6A-1xi8A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yhf HYPOTHETICAL PROTEIN
SPY1581

(Streptococcus
pyogenes) 		PF07883
(Cupin_2) 		4 LEU A  15
LEU A 104
MET A  60
THR A  84
 None
 0.98A 5hs6A-1yhfA:
undetectable		 5hs6A-1yhfA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c21 TRYPANOTHIONE-DEPEND
ENT GLYOXALASE I

(Leishmania
major) 		PF00903
(Glyoxalase) 		4 TYR A 117
LEU A  60
LEU A  58
THR A  56
 None
 1.12A 5hs6A-2c21A:
undetectable		 5hs6A-2c21A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpn GLYCEROL KINASE

(Thermus
thermophilus) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 HIS A  96
LEU A 149
LEU A 142
THR A 106
 None
 1.10A 5hs6A-2dpnA:
undetectable		 5hs6A-2dpnA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gaf POLY(A) POLYMERASE
CATALYTIC SUBUNIT

(Vaccinia virus) 		PF03296
(Pox_polyA_pol)
PF12629
(Pox_polyA_pol_C)
PF12630
(Pox_polyA_pol_N) 		4 GLN D 207
LEU D 115
LEU D 112
THR D 107
 None
 1.14A 5hs6A-2gafD:
undetectable		 5hs6A-2gafD:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ilx 2',3'-CYCLIC-NUCLEOT
IDE
3'-PHOSPHODIESTERASE

(Rattus
norvegicus) 		PF05881
(CNPase) 		4 GLN A 119
LEU A 169
LEU A 168
THR A 112
 None
 0.94A 5hs6A-2ilxA:
undetectable		 5hs6A-2ilxA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipf (3(17)ALPHA-HYDROXYS
TEROID
DEHYDROGENASE)

(Mus musculus) 		PF00248
(Aldo_ket_red) 		4 TYR A  81
LEU A 103
LEU A  99
MET A 151
 None
 1.16A 5hs6A-2ipfA:
undetectable		 5hs6A-2ipfA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipj ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		4 TYR A  81
LEU A 103
LEU A  99
MET A 151
 None
 1.17A 5hs6A-2ipjA:
undetectable		 5hs6A-2ipjA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivd PROTOPORPHYRINOGEN
OXIDASE

(Myxococcus
xanthus) 		PF01593
(Amino_oxidase) 		4 HIS A 437
LEU A 458
LEU A 462
THR A  33
 None
 1.18A 5hs6A-2ivdA:
5.9		 5hs6A-2ivdA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k3q TUSP1

(Nephila
antipodiana) 		PF16763
(Spidroin_N) 		4 GLN A  55
LEU A   7
LEU A  10
THR A  62
 None
 1.14A 5hs6A-2k3qA:
undetectable		 5hs6A-2k3qA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m6r FLAVODOXIN

(Escherichia
coli) 		PF00258
(Flavodoxin_1) 		4 GLN A 114
LEU A  45
TRP A  44
LEU A  41
 None
 1.11A 5hs6A-2m6rA:
2.1		 5hs6A-2m6rA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mbg RALA-BINDING PROTEIN
1

(Homo sapiens) 		PF00620
(RhoGAP) 		4 HIS A 413
GLN A 417
LEU A 409
LEU A 429
 None
 1.06A 5hs6A-2mbgA:
undetectable		 5hs6A-2mbgA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pvc DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3-LIKE

(Homo sapiens) 		no annotation 4 HIS B 264
GLN B 268
LEU B 260
LEU B 302
 None
 1.14A 5hs6A-2pvcB:
5.7		 5hs6A-2pvcB:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r39 FIXG-RELATED PROTEIN

(Vibrio
parahaemolyticus) 		PF11614
(FixG_C) 		4 TYR A 418
LEU A 444
LEU A 446
MET A 448
 None
 0.99A 5hs6A-2r39A:
undetectable		 5hs6A-2r39A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r8q CLASS I
PHOSPHODIESTERASE
PDEB1

(Leishmania
major) 		PF00233
(PDEase_I) 		4 HIS A 694
TYR A 698
LEU A 715
LEU A 647
 None
 1.15A 5hs6A-2r8qA:
undetectable		 5hs6A-2r8qA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rae TRANSCRIPTIONAL
REGULATOR, ACRR
FAMILY PROTEIN

(Rhodococcus
jostii) 		PF00440
(TetR_N) 		4 LEU A 182
LEU A 186
MET A 190
THR A  94
 None
 1.18A 5hs6A-2raeA:
undetectable		 5hs6A-2raeA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vvy PROTEIN B15

(Vaccinia virus) 		PF06227
(Poxvirus) 		4 HIS A  14
GLN A  28
LEU A  50
LEU A  20
 None
 1.17A 5hs6A-2vvyA:
undetectable		 5hs6A-2vvyA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT

(Escherichia
coli) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 TYR A 355
LEU A 408
LEU A 405
THR A 134
 FAD  A 601 (-4.3A)
FAD  A 601 (-4.0A)
FAD  A 601 (-3.6A)
None
 1.13A 5hs6A-2wu5A:
undetectable		 5hs6A-2wu5A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzv NFNB PROTEIN

(Mycolicibacterium
smegmatis) 		PF00881
(Nitroreductase) 		4 GLN A 180
LEU A  73
LEU A  77
THR A 131
 None
 1.12A 5hs6A-2wzvA:
undetectable		 5hs6A-2wzvA:
26.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1

(Gracilariopsis
lemaneiformis) 		PF01055
(Glyco_hydro_31) 		4 TYR A 399
LEU A 409
LEU A 454
THR A 897
 None
 1.02A 5hs6A-2x2iA:
undetectable		 5hs6A-2x2iA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cfx UPF0100 PROTEIN
MA_0280

(Methanosarcina
acetivorans) 		PF13531
(SBP_bac_11) 		4 TRP A 142
LEU A 146
MET A 188
THR A 171
 None
 1.04A 5hs6A-3cfxA:
undetectable		 5hs6A-3cfxA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cwg SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 3

(Mus musculus) 		PF00017
(SH2)
PF01017
(STAT_alpha)
PF02864
(STAT_bind) 		4 HIS A 147
LEU A 148
LEU A 144
THR A 138
 None
 1.02A 5hs6A-3cwgA:
undetectable		 5hs6A-3cwgA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7r ESTERASE

(Staphylococcus
aureus) 		PF07859
(Abhydrolase_3) 		4 HIS A  83
GLN A  90
TRP A  96
LEU A 112
 None
 1.09A 5hs6A-3d7rA:
2.2		 5hs6A-3d7rA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f67 PUTATIVE
DIENELACTONE
HYDROLASE

(Klebsiella
pneumoniae) 		PF01738
(DLH) 		4 HIS A  44
TYR A 215
LEU A  48
THR A 117
 None
 1.07A 5hs6A-3f67A:
4.5		 5hs6A-3f67A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fru BETA-2-MICROGLOBULIN
NEONATAL FC RECEPTOR

(Rattus
norvegicus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 GLN A  93
LEU A  21
LEU B  54
THR A  27
 None
 0.96A 5hs6A-3fruA:
undetectable		 5hs6A-3fruA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fvq FE(3+) IONS IMPORT
ATP-BINDING PROTEIN
FBPC

(Neisseria
gonorrhoeae) 		PF00005
(ABC_tran) 		4 GLN A 282
TYR A 283
LEU A 259
LEU A 262
 None
 1.13A 5hs6A-3fvqA:
undetectable		 5hs6A-3fvqA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hfs ANTHOCYANIDIN
REDUCTASE

(Vitis vinifera) 		PF01370
(Epimerase) 		4 TYR A 317
LEU A  28
LEU A  24
THR A 204
 None
 1.16A 5hs6A-3hfsA:
14.0		 5hs6A-3hfsA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ij6 UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE

(Lactobacillus
acidophilus) 		PF04909
(Amidohydro_2) 		4 HIS A 204
TYR A   8
LEU A 180
TRP A 176
 ZN  A 312 (-3.6A)
None
None
None
 1.01A 5hs6A-3ij6A:
undetectable		 5hs6A-3ij6A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kg9 CURK

(Lyngbya
majuscula) 		PF14765
(PS-DH) 		4 GLN A1199
LEU A1150
LEU A1167
THR A1007
 None
 1.17A 5hs6A-3kg9A:
undetectable		 5hs6A-3kg9A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3knz PUTATIVE SUGAR
BINDING PROTEIN

(Salmonella
enterica) 		PF01380
(SIS) 		4 HIS A 144
GLN A 315
LEU A   8
LEU A 183
 None
 1.04A 5hs6A-3knzA:
4.9		 5hs6A-3knzA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksy SON OF SEVENLESS
HOMOLOG 1

(Homo sapiens) 		PF00125
(Histone)
PF00169
(PH)
PF00617
(RasGEF)
PF00618
(RasGEF_N)
PF00621
(RhoGEF) 		4 GLN A 975
LEU A 821
LEU A 804
THR A 629
 None
 1.05A 5hs6A-3ksyA:
undetectable		 5hs6A-3ksyA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l8k DIHYDROLIPOYL
DEHYDROGENASE

(Sulfolobus
solfataricus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 LEU A 395
TRP A 408
LEU A 393
MET A 377
 None
 1.09A 5hs6A-3l8kA:
5.9		 5hs6A-3l8kA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p4s FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT

(Escherichia
coli) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 TYR A 356
LEU A 399
LEU A 396
THR A 124
 FAD  A 601 (-4.4A)
FAD  A 601 (-4.1A)
FAD  A 601 (-3.8A)
None
 1.03A 5hs6A-3p4sA:
undetectable		 5hs6A-3p4sA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r6n DESMOPLAKIN

(Homo sapiens) 		no annotation 4 LEU A 536
TRP A 537
LEU A 540
MET A 544
 None
 0.94A 5hs6A-3r6nA:
undetectable		 5hs6A-3r6nA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s4l CAS3 METAL DEPENDENT
PHOSPHOHYDROLASE

(Methanocaldococcus
jannaschii) 		no annotation 4 HIS A 123
LEU A 212
LEU A 215
MET A  24
 CA  A 501 (-3.5A)
None
None
None
 1.02A 5hs6A-3s4lA:
undetectable		 5hs6A-3s4lA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sg1 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1

(Bacillus
anthracis) 		PF00275
(EPSP_synthase) 		4 HIS A 335
GLN A 308
LEU A 377
THR A 239
 None
 1.04A 5hs6A-3sg1A:
undetectable		 5hs6A-3sg1A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqg METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT

(uncultured
archaeon) 		PF02240
(MCR_gamma) 		4 TYR C 109
LEU C  25
LEU C 142
THR C 148
 GOL  C 281 (-4.6A)
None
None
None
 1.05A 5hs6A-3sqgC:
undetectable		 5hs6A-3sqgC:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sut BETA-HEXOSAMINIDASE

(Paenibacillus
sp. TS12) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b) 		4 HIS A 485
GLN A 129
LEU A 482
LEU A 460
 None
 1.10A 5hs6A-3sutA:
undetectable		 5hs6A-3sutA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swd UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Escherichia
coli) 		PF00275
(EPSP_synthase) 		4 HIS A 334
GLN A 307
LEU A 376
THR A 237
 None
 1.15A 5hs6A-3swdA:
undetectable		 5hs6A-3swdA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swe UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Haemophilus
influenzae) 		PF00275
(EPSP_synthase) 		4 HIS A 336
GLN A 309
LEU A 378
THR A 239
 None
 1.16A 5hs6A-3sweA:
undetectable		 5hs6A-3sweA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swg UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Aquifex
aeolicus) 		PF00275
(EPSP_synthase) 		4 HIS A 340
GLN A 313
LEU A 382
THR A 244
 None
 1.03A 5hs6A-3swgA:
undetectable		 5hs6A-3swgA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tlk FERRIENTEROBACTIN-BI
NDING PERIPLASMIC
PROTEIN

(Escherichia
coli) 		PF01497
(Peripla_BP_2) 		4 GLN A 269
TYR A 276
LEU A 262
LEU A 264
 None
 0.97A 5hs6A-3tlkA:
3.6		 5hs6A-3tlkA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zh4 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Streptococcus
pneumoniae) 		PF00275
(EPSP_synthase) 		4 HIS A 335
GLN A 308
LEU A 339
THR A 239
 None
 1.16A 5hs6A-3zh4A:
undetectable		 5hs6A-3zh4A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1o BETA-XYLOSIDASE

(Parageobacillus
thermoglucosidasius) 		PF03512
(Glyco_hydro_52) 		4 HIS A 684
LEU A 688
LEU A 655
THR A 718
 None
 1.18A 5hs6A-4c1oA:
undetectable		 5hs6A-4c1oA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4flm S-FORMYLGLUTATHIONE
HYDROLASE

(Saccharomyces
cerevisiae) 		PF00756
(Esterase) 		4 LEU A 137
LEU A 133
MET A 125
THR A  24
 None
 0.97A 5hs6A-4flmA:
2.1		 5hs6A-4flmA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1

(Trypanosoma
brucei) 		PF00233
(PDEase_I) 		4 HIS A 682
TYR A 686
LEU A 703
LEU A 635
 None
 1.13A 5hs6A-4i15A:
undetectable		 5hs6A-4i15A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iqq THYMIDYLATE SYNTHASE

(Caenorhabditis
elegans) 		PF00303
(Thymidylat_synt) 		4 HIS A 252
GLN A 216
LEU A 250
LEU A 229
 None
UMP  A 401 (-4.4A)
None
None
 1.15A 5hs6A-4iqqA:
undetectable		 5hs6A-4iqqA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iug BETA-GALACTOSIDASE A

(Aspergillus
oryzae) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 HIS A 473
LEU A 447
LEU A 445
THR A 411
 None
 1.18A 5hs6A-4iugA:
undetectable		 5hs6A-4iugA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6j WINGS APART-LIKE
PROTEIN HOMOLOG

(Homo sapiens) 		PF07814
(WAPL) 		4 LEU A 750
LEU A 747
MET A 724
THR A 798
 None
 1.12A 5hs6A-4k6jA:
undetectable		 5hs6A-4k6jA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ko2 PERIPLASMIC [NIFESE]
HYDROGENASE SMALL
SUBUNIT

(Desulfomicrobium
baculatum) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		4 HIS S  46
GLN S  14
LEU S  43
MET S 171
 None
 1.14A 5hs6A-4ko2S:
3.3		 5hs6A-4ko2S:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m64 MELIBIOSE CARRIER
PROTEIN

(Salmonella
enterica) 		PF13347
(MFS_2) 		4 TYR A  28
LEU A  94
LEU A  91
THR A 119
 None
 1.06A 5hs6A-4m64A:
undetectable		 5hs6A-4m64A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mbg CAAX
FARNESYLTRANSFERASE
BETA SUBUNIT RAM1

(Aspergillus
fumigatus) 		PF00432
(Prenyltrans) 		4 HIS B 129
GLN B 415
LEU B 165
LEU B 438
 None
 1.14A 5hs6A-4mbgB:
undetectable		 5hs6A-4mbgB:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n01 PERIPLASMIC BINDING
PROTEIN

(Veillonella
parvula) 		PF01497
(Peripla_BP_2) 		4 GLN A 217
LEU A 292
MET A 239
THR A 220
 None
 1.17A 5hs6A-4n01A:
2.9		 5hs6A-4n01A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nao PUTATIVE OXYGENASE

(Claviceps
purpurea) 		PF05721
(PhyH) 		4 HIS A 141
GLN A 138
LEU A 189
TRP A 140
 FE2  A 404 ( 3.7A)
AKG  A 402 (-3.5A)
None
None
 0.86A 5hs6A-4naoA:
undetectable		 5hs6A-4naoA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ohx PROTEIN CLPF-1

(Caenorhabditis
elegans) 		PF06807
(Clp1)
PF16573
(CLP1_N)
PF16575
(CLP1_P) 		4 HIS A 421
LEU A 366
LEU A 389
THR A 317
 None
 1.04A 5hs6A-4ohxA:
3.3		 5hs6A-4ohxA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4okj 3'-5'
EXORIBONUCLEASE
RV2179C/MT2234.1

(Mycobacterium
tuberculosis) 		PF16473
(DUF5051) 		4 TYR A   5
LEU A  73
LEU A  77
THR A 112
 None
 1.18A 5hs6A-4okjA:
undetectable		 5hs6A-4okjA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p37 PUTATIVE POLY(A)
POLYMERASE CATALYTIC
SUBUNIT

(Megavirus
chiliensis) 		no annotation 4 TYR B 373
LEU B 201
LEU B 200
THR B  76
 PEG  B 602 ( 4.5A)
None
None
None
 0.90A 5hs6A-4p37B:
undetectable		 5hs6A-4p37B:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q0m L-ASPARAGINASE

(Pyrococcus
furiosus) 		PF00710
(Asparaginase) 		4 HIS A  81
LEU A  63
TRP A  60
THR A 297
 None
 1.12A 5hs6A-4q0mA:
undetectable		 5hs6A-4q0mA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q65 DIPEPTIDE PERMEASE D

(Escherichia
coli) 		PF00854
(PTR2) 		4 GLN A 286
LEU A 384
LEU A 362
THR A 463
 None
 1.05A 5hs6A-4q65A:
undetectable		 5hs6A-4q65A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q8g PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2

(Saccharomyces
cerevisiae) 		PF13423
(UCH_1) 		4 GLN A 693
LEU A 739
LEU A 741
THR A 744
 None
 1.14A 5hs6A-4q8gA:
undetectable		 5hs6A-4q8gA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qhr ALANINE RACEMASE

(Acinetobacter
baumannii) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 GLN A 175
TRP A 200
LEU A 203
MET A 158
 None
 1.18A 5hs6A-4qhrA:
2.7		 5hs6A-4qhrA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7u UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Vibrio cholerae) 		PF00275
(EPSP_synthase) 		4 HIS A 335
GLN A 308
LEU A 339
THR A 238
 None
 1.17A 5hs6A-4r7uA:
undetectable		 5hs6A-4r7uA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ra6 L-ASPARAGINASE

(Pyrococcus
furiosus) 		PF00710
(Asparaginase)
no annotation 		4 HIS A  81
LEU A  63
TRP A  60
THR B 297
 None
 1.17A 5hs6A-4ra6A:
2.4		 5hs6A-4ra6A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xrt STFQ
AROMATASE/CYCLASE

(Streptomyces
steffisburgensis) 		PF03364
(Polyketide_cyc) 		4 HIS A 240
LEU A 233
MET A 202
THR A 204
 None
 0.93A 5hs6A-4xrtA:
undetectable		 5hs6A-4xrtA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xt1 G-PROTEIN COUPLED
RECEPTOR HOMOLOG
US28

(Cytomegalovirus) 		PF00001
(7tm_1) 		4 HIS A 162
TYR A 112
LEU A 188
THR A 252
 None
 1.11A 5hs6A-4xt1A:
undetectable		 5hs6A-4xt1A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aw4 NA, K-ATPASE ALPHA
SUBUNIT

(Squalus
acanthias) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		4 GLN A 930
LEU A 954
LEU A 822
THR A 339
 None
 1.05A 5hs6A-5aw4A:
4.9		 5hs6A-5aw4A:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b5u L-ASPARAGINASE

(Pyrococcus
furiosus) 		PF00710
(Asparaginase)
no annotation 		4 HIS A  81
LEU A  63
TRP A  60
THR B 297
 None
 1.16A 5hs6A-5b5uA:
3.9		 5hs6A-5b5uA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bq2 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Pseudomonas
aeruginosa) 		PF00275
(EPSP_synthase) 		4 HIS A 337
GLN A 310
LEU A 379
THR A 240
 None
 1.00A 5hs6A-5bq2A:
undetectable		 5hs6A-5bq2A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ek8 LIPOXYGENASE

(Cyanothece sp.
PCC 8801) 		PF00305
(Lipoxygenase) 		4 TYR A 516
LEU A 255
LEU A 304
THR A 307
 None
 1.10A 5hs6A-5ek8A:
undetectable		 5hs6A-5ek8A:
17.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5en4 17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14

(Homo sapiens) 		PF13561
(adh_short_C2) 		8 HIS A  93
GLN A 148
TYR A 154
LEU A 191
TRP A 192
LEU A 195
MET A 199
THR A 205
 5Q6  A 302 (-3.5A)
5Q6  A 302 (-3.6A)
5Q6  A 302 ( 4.3A)
NAD  A 301 (-3.6A)
5Q6  A 302 ( 3.3A)
5Q6  A 302 (-4.1A)
None
None
 0.33A 5hs6A-5en4A:
45.6		 5hs6A-5en4A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eup CENTROSOME-ASSOCIATE
D ZINC FINGER
PROTEIN CP190

(Drosophila
melanogaster) 		PF00651
(BTB) 		4 LEU A 118
LEU A 115
MET A 110
THR A  53
 None
 0.81A 5hs6A-5eupA:
undetectable		 5hs6A-5eupA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hjl TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE

(Streptococcus
porcinus) 		PF01791
(DeoC) 		4 GLN A 236
LEU A 247
MET A 211
THR A 259
 None
SO4  A 401 ( 4.5A)
None
None
 1.18A 5hs6A-5hjlA:
2.3		 5hs6A-5hjlA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihr PROBABLE
BETA-GALACTOSIDASE A

(Aspergillus
niger) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 HIS A 473
LEU A 447
LEU A 445
THR A 411
 None
 1.16A 5hs6A-5ihrA:
undetectable		 5hs6A-5ihrA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j1f PLECTIN,PLECTIN

(Homo sapiens) 		no annotation 4 LEU A 909
TRP A 910
LEU A 913
MET A 917
 None
 1.10A 5hs6A-5j1fA:
undetectable		 5hs6A-5j1fA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3x NEGATIVE ELONGATION
FACTOR C/D

(Homo sapiens) 		PF04858
(TH1) 		4 GLN B 442
TYR B 440
LEU B 492
LEU B 484
 None
 0.94A 5hs6A-5l3xB:
undetectable		 5hs6A-5l3xB:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lq3 CMEB

(Campylobacter
jejuni) 		PF00873
(ACR_tran) 		4 LEU A 998
LEU A1002
MET A1006
THR A 978
 None
 1.15A 5hs6A-5lq3A:
undetectable		 5hs6A-5lq3A:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqp GLYCOSIDE HYDROLASE
BT_1002

(Bacteroides
thetaiotaomicron) 		no annotation 4 HIS A 233
GLN A 230
LEU A 335
LEU A 341
 None
 1.11A 5hs6A-5mqpA:
undetectable		 5hs6A-5mqpA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nh1 GASDERMIN-D

(Homo sapiens) 		PF04598
(Gasdermin) 		4 HIS A 386
GLN A 323
LEU A 389
LEU A 320
 None
 1.16A 5hs6A-5nh1A:
undetectable		 5hs6A-5nh1A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Homo sapiens) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 TYR A3586
LEU A3627
LEU A3623
THR A3612
 None
 1.13A 5hs6A-5nugA:
undetectable		 5hs6A-5nugA:
4.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ouo PERFORIN-LIKE
PROTEIN 1

(Toxoplasma
gondii) 		no annotation 4 TYR A 975
LEU A 816
LEU A 981
THR A1071
 None
 1.17A 5hs6A-5ouoA:
undetectable		 5hs6A-5ouoA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sy5 ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
NEURONAL PAS
DOMAIN-CONTAINING
PROTEIN 1

(Mus musculus) 		PF00010
(HLH)
PF00989
(PAS)
PF08447
(PAS_3)
PF14598
(PAS_11) 		4 HIS B 272
GLN A 344
LEU B 291
THR A 309
 None
 1.08A 5hs6A-5sy5B:
undetectable		 5hs6A-5sy5B:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5txk UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE
35,UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 35

(Homo sapiens) 		no annotation 4 TYR A 527
LEU A 480
LEU A 532
THR A 564
 None
 1.02A 5hs6A-5txkA:
undetectable		 5hs6A-5txkA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujs UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Campylobacter
jejuni) 		PF00275
(EPSP_synthase) 		4 HIS A 334
GLN A 307
LEU A 376
THR A 238
 None
 1.05A 5hs6A-5ujsA:
undetectable		 5hs6A-5ujsA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wi5 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1

(Streptococcus
pneumoniae) 		PF00275
(EPSP_synthase) 		4 HIS A 338
GLN A 311
LEU A 380
THR A 241
 None
 1.13A 5hs6A-5wi5A:
undetectable		 5hs6A-5wi5A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wka BETA-GLUCOSIDASE

(metagenome) 		no annotation 4 TYR A 360
LEU A 218
TRP A 245
LEU A 216
 None
 1.09A 5hs6A-5wkaA:
2.1		 5hs6A-5wkaA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cn1 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Pseudomonas
putida) 		no annotation 4 HIS A 337
GLN A 310
LEU A 379
THR A 240
 None
 0.97A 5hs6A-6cn1A:
undetectable		 5hs6A-6cn1A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6du8 -

(-) 		no annotation 4 GLN A 202
LEU A 285
TRP A 158
LEU A 288
 None
 1.11A 5hs6A-6du8A:
undetectable		 5hs6A-6du8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ez8 HUNTINGTIN

(Homo sapiens) 		no annotation 4 LEU A 958
LEU A1828
MET A1821
THR A1824
 None
 1.14A 5hs6A-6ez8A:
undetectable		 5hs6A-6ez8A:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3

(Homo sapiens) 		no annotation 4 TYR A  81
LEU A 103
LEU A  99
MET A 151
 None
 1.11A 5hs6A-6f2uA:
undetectable		 5hs6A-6f2uA:
15.93