SIMILAR PATTERNS OF AMINO ACIDS FOR 5HS1_A_VORA602_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b63 MUTL

(Escherichia
coli) 		PF01119
(DNA_mis_repair)
PF13589
(HATPase_c_3) 		4 GLY A  62
THR A 143
LEU A 110
LEU A  72
 ANP  A 380 (-4.1A)
ANP  A 380 (-3.7A)
None
None
 0.74A 5hs1A-1b63A:
undetectable		 5hs1A-1b63A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dc1 BSOBI RESTRICTION
ENDONUCLEASE

(Geobacillus
stearothermophilus) 		PF09194
(Endonuc-BsobI) 		4 ILE A 320
GLY A 239
LEU A 301
LEU A 296
 None
 0.84A 5hs1A-1dc1A:
undetectable		 5hs1A-1dc1A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1c METHYLMALONYL-COA
MUTASE ALPHA CHAIN

(Propionibacterium
freudenreichii) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding) 		4 PHE A 117
ILE A 174
LEU A 158
LEU A 192
 None
 0.76A 5hs1A-1e1cA:
undetectable		 5hs1A-1e1cA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hk7 HEAT SHOCK PROTEIN
HSP82

(Saccharomyces
cerevisiae) 		PF00183
(HSP90) 		4 PHE A 317
ILE A 392
PHE A 309
LEU A 362
 None
 0.88A 5hs1A-1hk7A:
undetectable		 5hs1A-1hk7A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ihm CAPSID PROTEIN

(Norwalk virus) 		PF00915
(Calici_coat)
PF08435
(Calici_coat_C) 		4 GLY A1115
THR A1119
LEU A1190
LEU A1186
 None
 0.88A 5hs1A-1ihmA:
undetectable		 5hs1A-1ihmA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l0q SURFACE LAYER
PROTEIN

(Methanosarcina
mazei) 		PF00801
(PKD)
PF10282
(Lactonase) 		4 PHE A 294
ILE A   6
GLY A 248
THR A 217
 None
 0.87A 5hs1A-1l0qA:
undetectable		 5hs1A-1l0qA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l7p PHOSPHOSERINE
PHOSPHATASE

(Methanocaldococcus
jannaschii) 		PF12710
(HAD) 		4 ILE A 206
GLY A  80
LEU A 113
LEU A 115
 None
 0.80A 5hs1A-1l7pA:
undetectable		 5hs1A-1l7pA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ozh ACETOLACTATE
SYNTHASE, CATABOLIC

(Klebsiella
pneumoniae) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 PHE A 408
ILE A 401
LEU A 521
LEU A 371
 None
 0.79A 5hs1A-1ozhA:
undetectable		 5hs1A-1ozhA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4n AMYLOID BETA
PRECURSOR
PROTEIN-BINDING
PROTEIN 1
UBIQUITIN-ACTIVATING
ENZYME E1C

(Homo sapiens) 		PF00899
(ThiF)
PF08825
(E2_bind) 		4 ILE A 493
THR B 332
LEU B 322
LEU B 318
 None
 0.79A 5hs1A-1r4nA:
undetectable		 5hs1A-1r4nA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r5m SIR4-INTERACTING
PROTEIN SIF2

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		4 ILE A 356
GLY A 336
LEU A 365
LEU A 374
 None
 0.84A 5hs1A-1r5mA:
undetectable		 5hs1A-1r5mA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tjr BX1

(Zea mays) 		PF00290
(Trp_syntA) 		4 GLY A 111
THR A 118
LEU A 135
LEU A 183
 None
 0.84A 5hs1A-1tjrA:
undetectable		 5hs1A-1tjrA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2

(Streptomyces
coelicolor) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 ILE B 144
GLY B 186
LEU B 168
LEU B 236
 None
 0.84A 5hs1A-1tqyB:
undetectable		 5hs1A-1tqyB:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tuo PUTATIVE
PHOSPHOMANNOMUTASE

(Thermus
thermophilus) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 ILE A  12
PHE A 120
LEU A 106
LEU A 116
 None
 0.84A 5hs1A-1tuoA:
undetectable		 5hs1A-1tuoA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ud9 DNA POLYMERASE
SLIDING CLAMP A

(Sulfurisphaera
tokodaii) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		4 TYR A   5
PHE A  27
ILE A  34
LEU A 210
 None
 0.88A 5hs1A-1ud9A:
undetectable		 5hs1A-1ud9A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x8v CYTOCHROME P450 51

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		5 TYR A  76
PHE A  83
THR A 260
LEU A 321
LEU A 324
 ESL  A 471 ( 3.8A)
None
HEM  A 470 (-3.6A)
HEM  A 470 (-4.1A)
HEM  A 470 ( 3.9A)
 0.91A 5hs1A-1x8vA:
35.5		 5hs1A-1x8vA:
27.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xa6 BETA2-CHIMAERIN

(Homo sapiens) 		PF00017
(SH2)
PF00130
(C1_1)
PF00620
(RhoGAP) 		4 ILE A 343
GLY A 308
LEU A 425
LEU A 408
 None
 0.81A 5hs1A-1xa6A:
undetectable		 5hs1A-1xa6A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xi8 MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN

(Pyrococcus
furiosus) 		PF00994
(MoCF_biosynth)
PF03453
(MoeA_N)
PF03454
(MoeA_C) 		5 PHE A 276
ILE A  16
GLY A 290
LEU A 253
LEU A 318
 None
 1.18A 5hs1A-1xi8A:
undetectable		 5hs1A-1xi8A:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9v GMP SYNTHASE

(Thermoplasma
acidophilum) 		PF00117
(GATase) 		4 TYR A  74
PHE A 183
GLY A  78
LEU A  40
 None
 0.71A 5hs1A-2a9vA:
undetectable		 5hs1A-2a9vA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE

(Thermotoga
maritima) 		PF00294
(PfkB) 		4 GLY A   7
THR A 136
LEU A 147
LEU A 151
 None
 0.82A 5hs1A-2afbA:
undetectable		 5hs1A-2afbA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cvh DNA REPAIR AND
RECOMBINATION
PROTEIN RADB

(Thermococcus
kodakarensis) 		PF08423
(Rad51) 		4 GLY A  16
THR A   4
LEU A  36
LEU A 182
 None
 0.87A 5hs1A-2cvhA:
undetectable		 5hs1A-2cvhA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6h MYOSIN-2

(Saccharomyces
cerevisiae) 		PF01843
(DIL) 		4 ILE X 244
GLY X 118
LEU X 183
LEU X 256
 None
 0.78A 5hs1A-2f6hX:
undetectable		 5hs1A-2f6hX:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9y ACETYL-COA
CARBOXYLASE,
CARBOXYLTRANSFERASE
ALPHA CHAIN
ACETYL-COENZYME A
CARBOXYLASE CARBOXYL
TRANSFERASE SUBUNIT
BETA

(Escherichia
coli) 		PF01039
(Carboxyl_trans)
PF03255
(ACCA) 		4 PHE B 227
ILE A 181
GLY A 165
LEU B 171
 None
 0.82A 5hs1A-2f9yB:
undetectable		 5hs1A-2f9yB:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hsj PUTATIVE PLATELET
ACTIVATING FACTOR

(Streptococcus
pneumoniae) 		PF13472
(Lipase_GDSL_2) 		4 GLY A  91
THR A  67
LEU A 108
LEU A 160
 None
 0.74A 5hs1A-2hsjA:
undetectable		 5hs1A-2hsjA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jzj CYANOVIRIN-N HOMOLOG

(Ceratopteris
richardii) 		PF08881
(CVNH) 		4 GLY A  56
THR A  62
LEU A  70
LEU A  88
 None
 0.85A 5hs1A-2jzjA:
undetectable		 5hs1A-2jzjA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kjz ATC0852

(Agrobacterium
fabrum) 		PF00903
(Glyoxalase) 		5 PHE A  39
GLY A  48
THR A   7
LEU A  68
LEU A 115
 None
 1.30A 5hs1A-2kjzA:
undetectable		 5hs1A-2kjzA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1t ENDOPLASMIN

(Canis lupus) 		PF00183
(HSP90) 		4 PHE A 383
ILE A 460
PHE A 375
LEU A 430
 None
 0.84A 5hs1A-2o1tA:
undetectable		 5hs1A-2o1tA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1v ENDOPLASMIN

(Canis lupus) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		4 PHE A 383
ILE A 460
PHE A 375
LEU A 430
 None
 0.87A 5hs1A-2o1vA:
undetectable		 5hs1A-2o1vA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1w ENDOPLASMIN

(Canis lupus) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		4 PHE A 383
ILE A 460
PHE A 375
LEU A 430
 None
 0.84A 5hs1A-2o1wA:
undetectable		 5hs1A-2o1wA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o7r CXE CARBOXYLESTERASE

(Actinidia
eriantha) 		PF07859
(Abhydrolase_3) 		4 PHE A 104
ILE A 103
GLY A  92
LEU A 222
 None
None
4PA  A 369 (-3.5A)
None
 0.81A 5hs1A-2o7rA:
undetectable		 5hs1A-2o7rA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phc UNCHARACTERIZED
PROTEIN PH0987

(Pyrococcus
horikoshii) 		PF02682
(CT_C_D) 		4 ILE B 181
GLY B 159
THR B 189
LEU B 137
 None
 0.87A 5hs1A-2phcB:
undetectable		 5hs1A-2phcB:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r8q CLASS I
PHOSPHODIESTERASE
PDEB1

(Leishmania
major) 		PF00233
(PDEase_I) 		4 PHE A 898
ILE A 902
LEU A 714
LEU A 697
 None
 0.87A 5hs1A-2r8qA:
undetectable		 5hs1A-2r8qA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wlb ELECTRON TRANSFER
PROTEIN 1,
MITOCHONDRIAL

(Schizosaccharomyces
pombe) 		PF00111
(Fer2) 		4 ILE A 617
GLY A 601
LEU A 588
LEU A 594
 None
 0.58A 5hs1A-2wlbA:
undetectable		 5hs1A-2wlbA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wlc POLYSIALIC ACID
O-ACETYLTRANSFERASE

(Neisseria
meningitidis) 		PF00132
(Hexapep) 		4 ILE A 139
GLY A 104
THR A  86
LEU A 109
 None
EDO  A1218 (-3.5A)
None
None
 0.79A 5hs1A-2wlcA:
undetectable		 5hs1A-2wlcA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwu IMPORTIN13

(Homo sapiens) 		PF03810
(IBN_N)
PF08389
(Xpo1) 		4 ILE B  84
PHE B  61
GLY B  78
LEU B  30
 None
 0.82A 5hs1A-2xwuB:
undetectable		 5hs1A-2xwuB:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yq4 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE

(Lactobacillus
delbrueckii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 ILE A 203
GLY A 259
LEU A 246
LEU A 223
 None
 0.85A 5hs1A-2yq4A:
undetectable		 5hs1A-2yq4A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8e YGHU, GLUTATHIONE
S-TRANSFERASE
HOMOLOGUE

(Escherichia
coli) 		PF02798
(GST_N)
PF13410
(GST_C_2) 		4 ILE A  82
GLY A  55
THR A  59
LEU A  47
 GSH  A 289 (-3.7A)
None
None
None
 0.81A 5hs1A-3c8eA:
2.2		 5hs1A-3c8eA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ef8 PUTATIVE SCYALONE
DEHYDRATASE

(Novosphingobium
aromaticivorans) 		PF13577
(SnoaL_4) 		4 TYR A  55
PHE A  47
LEU A  23
LEU A  31
 None
 0.80A 5hs1A-3ef8A:
undetectable		 5hs1A-3ef8A:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ego PROBABLE
2-DEHYDROPANTOATE
2-REDUCTASE

(Bacillus
subtilis) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		4 ILE A  38
GLY A   7
THR A  72
LEU A  19
 None
 0.82A 5hs1A-3egoA:
undetectable		 5hs1A-3egoA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fj4 MUCONATE
CYCLOISOMERASE

(Pseudomonas
protegens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ILE A  21
GLY A 332
THR A 303
LEU A  26
 None
None
MUC  A 383 (-4.6A)
None
 0.78A 5hs1A-3fj4A:
undetectable		 5hs1A-3fj4A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fmb DIMERIC PROTEIN OF
UNKNOWN FUNCTION AND
FERREDOXIN-LIKE FOLD

(Bacteroides
fragilis) 		PF07876
(Dabb) 		4 PHE A   8
ILE A  57
GLY A  82
LEU A  33
 None
 0.69A 5hs1A-3fmbA:
undetectable		 5hs1A-3fmbA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jbl NLR FAMILY CARD
DOMAIN-CONTAINING
PROTEIN 4

(Mus musculus) 		no annotation 4 PHE K 957
GLY K 928
LEU K 912
LEU K 939
 None
 0.87A 5hs1A-3jblK:
undetectable		 5hs1A-3jblK:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jr3 NAD-DEPENDENT
DEACETYLASE

(Thermotoga
maritima) 		PF02146
(SIR2) 		4 ILE A 245
PHE A   6
THR A  18
LEU A 187
 None
 0.73A 5hs1A-3jr3A:
undetectable		 5hs1A-3jr3A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khz PUTATIVE DIPEPTIDASE
SACOL1801

(Staphylococcus
aureus) 		PF01546
(Peptidase_M20) 		4 PHE A 373
GLY A 343
LEU A 206
LEU A 287
 None
 0.81A 5hs1A-3khzA:
undetectable		 5hs1A-3khzA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4d STEROL 14-ALPHA
DEMETHYLASE

(Leishmania
infantum) 		PF00067
(p450) 		4 TYR A 102
THR A 294
LEU A 355
LEU A 358
 HEM  A 481 (-4.7A)
TPF  A 490 ( 3.5A)
TPF  A 490 (-4.4A)
HEM  A 481 (-3.6A)
 0.53A 5hs1A-3l4dA:
39.7		 5hs1A-3l4dA:
28.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpp SUCRASE-ISOMALTASE

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		4 PHE A 589
ILE A 594
GLY A 243
THR A 229
 None
 0.84A 5hs1A-3lppA:
undetectable		 5hs1A-3lppA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mil ISOAMYL
ACETATE-HYDROLYZING
ESTERASE

(Saccharomyces
cerevisiae) 		PF13472
(Lipase_GDSL_2) 		4 ILE A 102
GLY A  10
THR A  14
LEU A 169
 None
 0.71A 5hs1A-3milA:
undetectable		 5hs1A-3milA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nra ASPARTATE
AMINOTRANSFERASE

(Rhodobacter
sphaeroides) 		PF00155
(Aminotran_1_2) 		4 ILE A 247
GLY A 109
LEU A 293
LEU A  86
 None
LLP  A 252 ( 3.5A)
None
None
 0.85A 5hs1A-3nraA:
undetectable		 5hs1A-3nraA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8c ABL INTERACTOR 2
NCK-ASSOCIATED
PROTEIN 1

(Homo sapiens) 		PF07815
(Abi_HHR)
PF09735
(Nckap1) 		4 ILE F 141
GLY B  24
THR B 139
LEU B 111
 None
 0.73A 5hs1A-3p8cF:
undetectable		 5hs1A-3p8cF:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfk UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		4 PHE A  88
ILE A  52
PHE A 134
LEU A 260
 None
 0.78A 5hs1A-3qfkA:
undetectable		 5hs1A-3qfkA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3skv SSFX3

(Streptomyces
sp. SF2575) 		PF13472
(Lipase_GDSL_2) 		4 ILE A 220
GLY A 172
LEU A 189
LEU A 200
 None
 0.81A 5hs1A-3skvA:
undetectable		 5hs1A-3skvA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0b OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN

(Mycolicibacterium
smegmatis) 		PF13561
(adh_short_C2) 		4 ILE A 177
GLY A 187
LEU A 411
LEU A  30
 None
 0.79A 5hs1A-3u0bA:
undetectable		 5hs1A-3u0bA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w2z METHYL-ACCEPTING
CHEMOTAXIS PROTEIN

(Nostoc sp. PCC
7120) 		PF01590
(GAF) 		4 TYR A  59
ILE A 137
GLY A 101
THR A  98
 CYC  A 201 (-4.0A)
CYC  A 201 (-4.7A)
None
None
 0.88A 5hs1A-3w2zA:
undetectable		 5hs1A-3w2zA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x0v L-LYSINE OXIDASE

(Trichoderma
viride) 		PF01593
(Amino_oxidase) 		4 TYR A  92
ILE A  90
GLY A 230
THR A  51
 None
 0.81A 5hs1A-3x0vA:
undetectable		 5hs1A-3x0vA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x0y DSZC

(Rhodococcus
erythropolis) 		PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2) 		4 ILE A 257
GLY A  91
LEU A  52
LEU A  58
 None
 0.84A 5hs1A-3x0yA:
undetectable		 5hs1A-3x0yA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayj BOGT -
METAL-INDEPENDENT
GLYCOSYLTRANSFERASE

(Bacteroides
ovatus) 		PF03414
(Glyco_transf_6) 		4 PHE A 100
PHE A  94
THR A 120
LEU A 118
 None
 0.87A 5hs1A-4ayjA:
undetectable		 5hs1A-4ayjA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bn5 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL

(Homo sapiens) 		PF02146
(SIR2) 		4 PHE A 327
GLY A 145
LEU A 225
LEU A 244
 None
CNA  A1395 ( 3.7A)
None
None
 0.81A 5hs1A-4bn5A:
undetectable		 5hs1A-4bn5A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4db1 MYOSIN-7

(Homo sapiens) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		4 PHE A 312
ILE A 356
GLY A 425
LEU A 399
 None
 0.88A 5hs1A-4db1A:
undetectable		 5hs1A-4db1A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dns FAD-LINKED
OXIDOREDUCTASE BG60

(Cynodon
dactylon) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 PHE A 358
ILE A 245
GLY A 272
LEU A 297
 None
 0.85A 5hs1A-4dnsA:
undetectable		 5hs1A-4dnsA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4g METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		4 ILE A 100
THR A 145
LEU A 170
LEU A 197
 None
 0.85A 5hs1A-4e4gA:
undetectable		 5hs1A-4e4gA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjl NAPHTHALENE
1,2-DIOXYGENASE
SUBUNIT ALPHA

(Pseudomonas sp.
C18) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		4 PHE A 432
GLY A 247
THR A 243
LEU A 443
 None
 0.85A 5hs1A-4hjlA:
undetectable		 5hs1A-4hjlA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1

(Trypanosoma
brucei) 		PF00233
(PDEase_I) 		4 PHE A 885
ILE A 889
LEU A 702
LEU A 685
 None
 0.76A 5hs1A-4i15A:
undetectable		 5hs1A-4i15A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k0e HEAVY METAL CATION
TRICOMPONENT EFFLUX
PUMP ZNEA(CZCA-LIKE)

(Cupriavidus
metallidurans) 		PF00873
(ACR_tran) 		4 ILE A 700
THR A 611
LEU A 577
LEU A 641
 None
 0.83A 5hs1A-4k0eA:
undetectable		 5hs1A-4k0eA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p53 CYCLASE

(Streptomyces
hygroscopicus) 		PF01761
(DHQ_synthase) 		4 ILE A 139
GLY A 133
THR A 158
LEU A 129
 None
NAI  A 502 (-3.2A)
NAI  A 502 (-3.5A)
None
 0.82A 5hs1A-4p53A:
undetectable		 5hs1A-4p53A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pua GLUTATHIONE
S-TRANSFERASE

(Streptococcus
pneumoniae) 		PF02798
(GST_N)
PF13410
(GST_C_2) 		4 ILE A  80
GLY A  53
THR A  57
LEU A  45
 GSH  A 302 ( 3.8A)
None
None
None
 0.87A 5hs1A-4puaA:
undetectable		 5hs1A-4puaA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pua GLUTATHIONE
S-TRANSFERASE

(Streptococcus
pneumoniae) 		PF02798
(GST_N)
PF13410
(GST_C_2) 		4 ILE A  80
GLY A  53
THR A  57
LEU A  75
 GSH  A 302 ( 3.8A)
None
None
None
 0.64A 5hs1A-4puaA:
undetectable		 5hs1A-4puaA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qnk IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
2, CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00475
(IGPD) 		4 ILE A  83
PHE A 179
THR A 187
LEU A 118
 None
 0.87A 5hs1A-4qnkA:
undetectable		 5hs1A-4qnkA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rz2 SITE-DETERMINING
PROTEIN

(Geobacillus
thermodenitrificans) 		PF10609
(ParA) 		4 PHE A 284
ILE A 119
PHE A 151
LEU A  78
 None
 0.82A 5hs1A-4rz2A:
undetectable		 5hs1A-4rz2A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xri PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		4 TYR A 821
PHE A 830
GLY A 815
LEU A 782
 None
 0.80A 5hs1A-4xriA:
undetectable		 5hs1A-4xriA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzr POLYKETIDE
BIOSYNTHESIS
CYTOCHROME P450 PKSS

(Bacillus
subtilis) 		PF00067
(p450) 		4 PHE A 168
ILE A 160
PHE A 193
LEU A 216
 PHE  A 168 ( 1.3A)
ILE  A 160 ( 0.6A)
PHE  A 193 ( 1.3A)
LEU  A 216 ( 0.6A)
 0.85A 5hs1A-4yzrA:
29.2		 5hs1A-4yzrA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z61 PHYTOSULFOKINE
RECEPTOR 1

(Daucus carota) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		4 PHE A 146
ILE A 126
LEU A  91
LEU A 112
 None
 0.84A 5hs1A-4z61A:
undetectable		 5hs1A-4z61A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zi5 P91

(metagenome) 		PF01738
(DLH) 		4 PHE A 236
GLY A  31
LEU A  98
LEU A 127
 None
 0.86A 5hs1A-4zi5A:
undetectable		 5hs1A-4zi5A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a6b N-ACETYL-BETA-D-GLUC
OSAMINIDASE

(Streptococcus
pneumoniae) 		PF00728
(Glyco_hydro_20) 		4 ILE D 617
GLY D 341
THR D 343
LEU D 494
 None
 0.87A 5hs1A-5a6bD:
undetectable		 5hs1A-5a6bD:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aov GLYOXYLATE REDUCTASE

(Pyrococcus
furiosus) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 ILE A 209
GLY A 263
LEU A 250
LEU A 227
 None
 0.83A 5hs1A-5aovA:
undetectable		 5hs1A-5aovA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czc MALONYL-COA-[ACYL-CA
RRIER-PROTEIN]
TRANSACYLASE

(Streptomyces
halstedii) 		no annotation 4 ILE A  78
GLY A 130
LEU A 235
LEU A 119
 None
 0.86A 5hs1A-5czcA:
undetectable		 5hs1A-5czcA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dnw SHKAI2IB

(Striga
hermonthica) 		PF12697
(Abhydrolase_6) 		4 ILE A 193
PHE A 157
GLY A  27
LEU A 247
 None
 0.81A 5hs1A-5dnwA:
undetectable		 5hs1A-5dnwA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e0e CYTOCHROME P450
FAMILY 2 SUBFAMILY B

(Neotoma lepida) 		PF00067
(p450) 		4 TYR A  79
ILE A  84
GLY A 366
LEU A  52
 None
 0.82A 5hs1A-5e0eA:
30.4		 5hs1A-5e0eA:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es9 LINEAR GRAMICIDIN
SYNTHETASE SUBUNIT A

(Brevibacillus
parabrevis) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00551
(Formyl_trans_N)
PF13193
(AMP-binding_C) 		4 ILE A 713
GLY A 727
LEU A 751
LEU A 760
 None
 0.82A 5hs1A-5es9A:
undetectable		 5hs1A-5es9A:
22.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fsa CYP51 VARIANT1

(Candida
albicans) 		PF00067
(p450) 		6 PHE A 126
ILE A 131
PHE A 228
GLY A 307
THR A 311
LEU A 376
 X2N  A 590 (-4.8A)
X2N  A 590 (-4.2A)
X2N  A 590 (-4.9A)
X2N  A 590 (-3.5A)
HEM  A 580 (-3.6A)
X2N  A 590 (-4.3A)
 0.63A 5hs1A-5fsaA:
55.8		 5hs1A-5fsaA:
59.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fsa CYP51 VARIANT1

(Candida
albicans) 		PF00067
(p450) 		6 TYR A 118
PHE A 126
ILE A 131
PHE A 228
GLY A 307
THR A 311
 X2N  A 590 ( 4.0A)
X2N  A 590 (-4.8A)
X2N  A 590 (-4.2A)
X2N  A 590 (-4.9A)
X2N  A 590 (-3.5A)
HEM  A 580 (-3.6A)
 0.39A 5hs1A-5fsaA:
55.8		 5hs1A-5fsaA:
59.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g56 CARBOHYDRATE BINDING
FAMILY 6

(Ruminiclostridium
thermocellum) 		PF00150
(Cellulase)
PF03422
(CBM_6) 		4 PHE A 150
THR A  67
LEU A  91
LEU A 129
 None
 0.73A 5hs1A-5g56A:
undetectable		 5hs1A-5g56A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gyz LUCIFERIN
4-MONOOXYGENASE

(Photinus
pyralis) 		PF00501
(AMP-binding) 		4 ILE A 434
GLY A 341
THR A 345
LEU A 418
 AMP  A 501 ( 4.5A)
7BV  A 500 (-3.9A)
None
None
 0.84A 5hs1A-5gyzA:
undetectable		 5hs1A-5gyzA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h2r PHOSPHODIESTERASE

(Trypanosoma
brucei) 		no annotation 4 PHE A 886
ILE A 890
LEU A 702
LEU A 685
 None
 0.73A 5hs1A-5h2rA:
undetectable		 5hs1A-5h2rA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h6b PUTATIVE SECRETED
LIPASE

(Streptomyces
sp. W007) 		PF01674
(Lipase_2) 		4 ILE A  80
GLY A 111
LEU A 131
LEU A 119
 None
 0.74A 5hs1A-5h6bA:
undetectable		 5hs1A-5h6bA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbo BETA-GLUCOSIDASE

(Trichoderma
harzianum) 		PF00232
(Glyco_hydro_1) 		4 PHE A 275
ILE A 274
GLY A 312
THR A 383
 None
 0.86A 5hs1A-5jboA:
undetectable		 5hs1A-5jboA:
21.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE

([Candida]
glabrata) 		PF00067
(p450) 		8 TYR A 127
PHE A 135
ILE A 140
PHE A 237
GLY A 315
THR A 319
LEU A 381
LEU A 384
 1YN  A 602 ( 3.8A)
1YN  A 602 ( 4.6A)
1YN  A 602 (-4.4A)
1YN  A 602 (-4.5A)
1YN  A 602 ( 3.6A)
HEM  A 601 ( 3.5A)
1YN  A 602 ( 4.7A)
HEM  A 601 (-3.6A)
 0.41A 5hs1A-5jlcA:
49.2		 5hs1A-5jlcA:
84.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k9x TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Legionella
pneumophila) 		PF00290
(Trp_syntA) 		4 GLY A  26
THR A  33
LEU A  50
LEU A  99
 None
 0.82A 5hs1A-5k9xA:
undetectable		 5hs1A-5k9xA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kyv LUCIFERIN
4-MONOOXYGENASE

(Photinus
pyralis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 ILE A 434
GLY A 341
THR A 345
LEU A 418
 SLU  A 601 ( 4.3A)
SLU  A 601 (-4.0A)
None
None
 0.86A 5hs1A-5kyvA:
undetectable		 5hs1A-5kyvA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5li8 PUTATIVE CYTOCHROME
P450 126

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		4 ILE A 119
GLY A 365
LEU A 250
LEU A 162
 None
HEM  A 501 (-3.3A)
KKK  A 502 ( 4.4A)
None
 0.76A 5hs1A-5li8A:
27.9		 5hs1A-5li8A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nvr TELOMERE LENGTH
REGULATOR PROTEIN
RIF1

(Saccharomyces
cerevisiae) 		PF12231
(Rif1_N) 		4 TYR A 407
PHE A 381
THR A 338
LEU A 369
 None
 0.75A 5hs1A-5nvrA:
undetectable		 5hs1A-5nvrA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o9h C5A ANAPHYLATOXIN
CHEMOTACTIC RECEPTOR
1

(Homo sapiens) 		no annotation 4 PHE A 251
GLY A 210
LEU A 167
LEU A 163
 None
None
None
9P2  A 401 (-4.7A)
 0.88A 5hs1A-5o9hA:
undetectable		 5hs1A-5o9hA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thg I-ONUI_E-HCCR5

(synthetic
construct) 		PF00961
(LAGLIDADG_1) 		4 ILE A  14
GLY A 177
LEU A  49
LEU A  57
 None
CA  A 401 (-4.2A)
None
None
 0.76A 5hs1A-5thgA:
undetectable		 5hs1A-5thgA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uhk O-GLCNACASE
TIM-BARREL DOMAIN

(Homo sapiens) 		PF07555
(NAGidase) 		4 PHE A 145
ILE A 198
PHE A 191
GLY A 140
 None
 0.84A 5hs1A-5uhkA:
undetectable		 5hs1A-5uhkA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wm4 SALICYLATE-AMP
LIGASE

(Streptomyces
gandocaensis) 		no annotation 4 ILE A  62
GLY A  69
LEU A 288
LEU A 248
 None
 0.86A 5hs1A-5wm4A:
undetectable		 5hs1A-5wm4A:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbp 3NT OXYGENASE ALPHA
SUBUNIT

(Diaphorobacter
sp. DS2) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		4 PHE A 430
GLY A 245
THR A 241
LEU A 441
 None
 0.85A 5hs1A-5xbpA:
undetectable		 5hs1A-5xbpA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxo PERIPLASMIC
BETA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		no annotation 4 PHE A 412
ILE A 509
PHE A 591
LEU A 447
 None
 0.85A 5hs1A-5xxoA:
undetectable		 5hs1A-5xxoA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zu5 ALGINATE LYASE

(Vibrio
splendidus) 		no annotation 4 PHE A 236
THR A 290
LEU A 232
LEU A 252
 None
 0.83A 5hs1A-5zu5A:
undetectable		 5hs1A-5zu5A:
10.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6ay4 CYP51, STEROL
14ALPHA-DEMETHYLASE

(Naegleria
fowleri) 		no annotation 4 TYR A 107
PHE A 114
THR A 297
LEU A 358
 TPF  A 506 (-4.2A)
TPF  A 506 (-4.4A)
HEM  A 501 (-3.4A)
TPF  A 506 ( 4.4A)
 0.66A 5hs1A-6ay4A:
42.8		 5hs1A-6ay4A:
32.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bnp UNCONVENTIONAL
MYOSIN-VI

(Sus scrofa) 		no annotation 4 PHE I 484
ILE I 488
LEU I  73
LEU I  68
 None
 0.73A 5hs1A-6bnpI:
undetectable		 5hs1A-6bnpI:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bxa TOLL-LIKE RECEPTOR
5B, VARIABLE
LYMPHOCYTE RECEPTOR
B CHIMERA
VARIABLE LYMPHOCYTE
RECEPTOR 2

(Danio rerio;
Eptatretus
burgeri;
Petromyzon
marinus) 		no annotation 4 ILE A  35
GLY C  55
LEU C  75
LEU C  99
 None
 0.83A 5hs1A-6bxaA:
undetectable		 5hs1A-6bxaA:
11.16