SIMILAR PATTERNS OF AMINO ACIDS FOR 5HRQ_G_IPHG101

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgn ICEBERG (PROTEASE
INHIBITOR)

(Homo sapiens) 		PF00619
(CARD) 		4 HIS A  75
LEU A  25
CYH A  69
CYH A  70
 None
 1.34A 5hrqD-1dgnA:
undetectable
5hrqG-1dgnA:
undetectable
5hrqH-1dgnA:
undetectable		 5hrqD-1dgnA:
14.93
5hrqG-1dgnA:
11.49
5hrqH-1dgnA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgn ICEBERG (PROTEASE
INHIBITOR)

(Homo sapiens) 		PF00619
(CARD) 		4 HIS A  75
LEU A  29
CYH A  69
CYH A  70
 None
 1.41A 5hrqD-1dgnA:
undetectable
5hrqG-1dgnA:
undetectable
5hrqH-1dgnA:
undetectable		 5hrqD-1dgnA:
14.93
5hrqG-1dgnA:
11.49
5hrqH-1dgnA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ef4 DNA-DIRECTED RNA
POLYMERASE

(Methanothermobacter
thermautotrophicus) 		PF01194
(RNA_pol_N) 		4 CYH A  44
CYH A   6
HIS A  51
LEU A  48
 ZN  A  56 (-2.3A)
ZN  A  56 (-2.2A)
None
None
 1.28A 5hrqD-1ef4A:
undetectable
5hrqG-1ef4A:
undetectable
5hrqH-1ef4A:
undetectable		 5hrqD-1ef4A:
18.18
5hrqG-1ef4A:
20.45
5hrqH-1ef4A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f20 NITRIC-OXIDE
SYNTHASE

(Rattus
norvegicus) 		PF00175
(NAD_binding_1)
PF00667
(FAD_binding_1) 		4 HIS A1391
CYH A1244
HIS A1235
LEU A1236
 None
 1.29A 5hrqD-1f20A:
undetectable
5hrqG-1f20A:
undetectable
5hrqH-1f20A:
undetectable		 5hrqD-1f20A:
7.35
5hrqG-1f20A:
4.43
5hrqH-1f20A:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyn FRUCTOSE-BISPHOSPHAT
E ALDOLASE II

(Escherichia
coli) 		PF01116
(F_bP_aldolase) 		4 LEU A 123
CYH A 157
HIS A 141
LEU A 171
 None
 1.11A 5hrqD-1gynA:
undetectable
5hrqG-1gynA:
undetectable
5hrqH-1gynA:
undetectable		 5hrqD-1gynA:
6.55
5hrqG-1gynA:
4.36
5hrqH-1gynA:
6.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h2t 80 KDA NUCLEAR CAP
BINDING PROTEIN

(Homo sapiens) 		PF02854
(MIF4G)
PF09088
(MIF4G_like)
PF09090
(MIF4G_like_2) 		4 HIS C 724
LEU C 725
CYH C 743
HIS C 777
 None
 1.48A 5hrqD-1h2tC:
undetectable
5hrqG-1h2tC:
undetectable
5hrqH-1h2tC:
undetectable		 5hrqD-1h2tC:
4.41
5hrqG-1h2tC:
2.59
5hrqH-1h2tC:
4.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ib1 SEROTONIN
N-ACETYLTRANSFERASE

(Ovis aries) 		PF00583
(Acetyltransf_1) 		4 LEU E 104
CYH E 193
HIS E 120
LEU E 121
 None
 1.35A 5hrqD-1ib1E:
undetectable
5hrqG-1ib1E:
undetectable
5hrqH-1ib1E:
undetectable		 5hrqD-1ib1E:
12.58
5hrqG-1ib1E:
7.95
5hrqH-1ib1E:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j5s URONATE ISOMERASE

(Thermotoga
maritima) 		PF02614
(UxaC) 		4 HIS A 161
LEU A 158
CYH A 149
HIS A 225
 None
 1.22A 5hrqD-1j5sA:
undetectable
5hrqG-1j5sA:
undetectable
5hrqH-1j5sA:
undetectable		 5hrqD-1j5sA:
5.38
5hrqG-1j5sA:
4.12
5hrqH-1j5sA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mzh DEOXYRIBOSE-PHOSPHAT
E ALDOLASE

(Aquifex
aeolicus) 		PF01791
(DeoC) 		4 CYH A 138
CYH A 157
HIS A 143
LEU A 113
 None
 1.40A 5hrqD-1mzhA:
undetectable
5hrqG-1mzhA:
undetectable
5hrqH-1mzhA:
undetectable		 5hrqD-1mzhA:
13.94
5hrqG-1mzhA:
6.74
5hrqH-1mzhA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nkq HYPOTHETICAL 28.8
KDA PROTEIN IN
PSD1-SKO1 INTERGENIC
REGION

(Saccharomyces
cerevisiae) 		PF01557
(FAA_hydrolase) 		4 LEU A 234
CYH A 231
CYH A 174
LEU A 118
 None
 1.24A 5hrqD-1nkqA:
undetectable
5hrqG-1nkqA:
undetectable
5hrqH-1nkqA:
undetectable		 5hrqD-1nkqA:
9.78
5hrqG-1nkqA:
6.25
5hrqH-1nkqA:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oe5 SINGLE-STRAND
SELECTIVE
MONOFUNCTIONAL
URACIL DNA
GLYCOSYLASE

(Xenopus laevis) 		no annotation 4 HIS A 175
LEU A  93
CYH A 210
LEU A 236
 None
 0.98A 5hrqD-1oe5A:
undetectable
5hrqG-1oe5A:
undetectable
5hrqH-1oe5A:
undetectable		 5hrqD-1oe5A:
9.21
5hrqG-1oe5A:
9.46
5hrqH-1oe5A:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sc0 HYPOTHETICAL PROTEIN
HI1161

(Haemophilus
influenzae) 		PF03061
(4HBT) 		4 HIS A  89
CYH A 126
HIS A  54
LEU A  53
 None
 1.30A 5hrqD-1sc0A:
undetectable
5hrqG-1sc0A:
undetectable
5hrqH-1sc0A:
undetectable		 5hrqD-1sc0A:
14.17
5hrqG-1sc0A:
10.62
5hrqH-1sc0A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tll NITRIC-OXIDE
SYNTHASE, BRAIN

(Rattus
norvegicus) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		4 HIS A1391
CYH A1244
HIS A1235
LEU A1236
 None
 1.33A 5hrqD-1tllA:
undetectable
5hrqG-1tllA:
undetectable
5hrqH-1tllA:
undetectable		 5hrqD-1tllA:
7.35
5hrqG-1tllA:
2.34
5hrqH-1tllA:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zc6 PROBABLE
N-ACETYLGLUCOSAMINE
KINASE

(Chromobacterium
violaceum) 		PF01869
(BcrAD_BadFG) 		4 LEU A 288
CYH A  77
HIS A  28
LEU A  27
 None
 1.11A 5hrqD-1zc6A:
undetectable
5hrqG-1zc6A:
undetectable
5hrqH-1zc6A:
undetectable		 5hrqD-1zc6A:
6.76
5hrqG-1zc6A:
5.21
5hrqH-1zc6A:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buj SERINE/THREONINE-PRO
TEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		4 HIS A 140
CYH A 133
HIS A 282
LEU A 286
 None
 1.42A 5hrqD-2bujA:
undetectable
5hrqG-2bujA:
undetectable
5hrqH-2bujA:
undetectable		 5hrqD-2bujA:
6.02
5hrqG-2bujA:
8.52
5hrqH-2bujA:
6.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0n PRECORRIN-2
C20-METHYLTRANSFERAS
E

(Chlorobaculum
tepidum) 		PF00590
(TP_methylase) 		4 LEU A 155
CYH A 232
HIS A 173
LEU A 170
 None
 1.40A 5hrqD-2e0nA:
undetectable
5hrqG-2e0nA:
undetectable
5hrqH-2e0nA:
undetectable		 5hrqD-2e0nA:
10.93
5hrqG-2e0nA:
6.63
5hrqH-2e0nA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ecm RING FINGER AND CHY
ZINC FINGER
DOMAIN-CONTAINING
PROTEIN 1

(Mus musculus) 		PF13639
(zf-RING_2) 		4 LEU A  48
CYH A  11
HIS A  29
LEU A  31
 ZN  A 401 ( 4.9A)
ZN  A 201 (-2.3A)
ZN  A 401 (-3.0A)
None
 1.46A 5hrqD-2ecmA:
undetectable
5hrqG-2ecmA:
undetectable
5hrqH-2ecmA:
undetectable		 5hrqD-2ecmA:
20.37
5hrqG-2ecmA:
21.28
5hrqH-2ecmA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix8 ELONGATION FACTOR 3A

(Saccharomyces
cerevisiae) 		PF00005
(ABC_tran) 		4 LEU A1655
CYH A1690
HIS A1915
LEU A1916
 None
 1.04A 5hrqD-2ix8A:
undetectable
5hrqG-2ix8A:
undetectable
5hrqH-2ix8A:
undetectable		 5hrqD-2ix8A:
3.39
5hrqG-2ix8A:
2.02
5hrqH-2ix8A:
3.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix8 ELONGATION FACTOR 3A

(Saccharomyces
cerevisiae) 		PF00005
(ABC_tran) 		4 LEU A1655
CYH A1690
HIS A1915
LEU A1916
 None
 1.25A 5hrqD-2ix8A:
undetectable
5hrqG-2ix8A:
undetectable
5hrqH-2ix8A:
undetectable		 5hrqD-2ix8A:
3.39
5hrqG-2ix8A:
2.02
5hrqH-2ix8A:
3.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k8d PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRB

(Methanothermobacter
thermautotrophicus) 		PF01641
(SelR) 		4 CYH A 116
CYH A 119
HIS A 122
LEU A 123
 ZN  A 155 ( 2.3A)
ZN  A 155 ( 2.4A)
None
None
 1.39A 5hrqD-2k8dA:
undetectable
5hrqG-2k8dA:
undetectable
5hrqH-2k8dA:
undetectable		 5hrqD-2k8dA:
9.70
5hrqG-2k8dA:
9.42
5hrqH-2k8dA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oga TRANSAMINASE

(Streptomyces
venezuelae) 		PF01041
(DegT_DnrJ_EryC1) 		4 HIS A 169
LEU A 253
CYH A 197
LEU A 246
 None
 1.27A 5hrqD-2ogaA:
undetectable
5hrqG-2ogaA:
undetectable
5hrqH-2ogaA:
undetectable		 5hrqD-2ogaA:
8.28
5hrqG-2ogaA:
7.26
5hrqH-2ogaA:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pft EXOCYTOSIS PROTEIN

(Mus musculus) 		PF03081
(Exo70) 		4 HIS A 356
LEU A 357
CYH A 285
LEU A 324
 None
 1.18A 5hrqD-2pftA:
undetectable
5hrqG-2pftA:
undetectable
5hrqH-2pftA:
undetectable		 5hrqD-2pftA:
4.38
5hrqG-2pftA:
3.29
5hrqH-2pftA:
4.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pgc UNCHARACTERIZED
PROTEIN

(uncultured
marine organism) 		no annotation 4 HIS A 185
LEU A 182
CYH A 133
LEU A 191
 None
 1.27A 5hrqD-2pgcA:
undetectable
5hrqG-2pgcA:
undetectable
5hrqH-2pgcA:
undetectable		 5hrqD-2pgcA:
8.38
5hrqG-2pgcA:
7.04
5hrqH-2pgcA:
8.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2quq CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
B

(Saccharomyces
cerevisiae) 		PF16846
(Cep3) 		4 HIS A 313
LEU A 312
CYH A 299
LEU A 257
 None
 1.17A 5hrqD-2quqA:
undetectable
5hrqG-2quqA:
undetectable
5hrqH-2quqA:
undetectable		 5hrqD-2quqA:
7.14
5hrqG-2quqA:
5.61
5hrqH-2quqA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ro1 TRANSCRIPTION
INTERMEDIARY FACTOR
1-BETA

(Homo sapiens) 		PF00628
(PHD) 		4 HIS A 652
LEU A 649
CYH A 640
CYH A 666
 None
None
ZN  A 301 (-2.2A)
ZN  A 301 ( 2.2A)
 1.21A 5hrqD-2ro1A:
undetectable
5hrqG-2ro1A:
undetectable
5hrqH-2ro1A:
undetectable		 5hrqD-2ro1A:
11.67
5hrqG-2ro1A:
11.21
5hrqH-2ro1A:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9k UNCHARACTERIZED
PROTEIN FLJ32312

(Homo sapiens) 		no annotation 4 CYH A 230
CYH A 233
HIS A 224
LEU A 226
 None
 1.31A 5hrqD-2v9kA:
undetectable
5hrqG-2v9kA:
undetectable
5hrqH-2v9kA:
undetectable		 5hrqD-2v9kA:
5.64
5hrqG-2v9kA:
4.03
5hrqH-2v9kA:
5.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wal GROWTH ARREST AND
DNA-DAMAGE-INDUCIBLE
PROTEIN GADD45 GAMMA

(Homo sapiens) 		PF01248
(Ribosomal_L7Ae) 		4 HIS A  77
LEU A  74
CYH A 119
LEU A  62
 MLA  A1161 (-4.0A)
None
None
None
 1.41A 5hrqD-2walA:
undetectable
5hrqG-2walA:
undetectable
5hrqH-2walA:
undetectable		 5hrqD-2walA:
6.92
5hrqG-2walA:
7.38
5hrqH-2walA:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c19 UNCHARACTERIZED
PROTEIN MK0293

(Methanopyrus
kandleri) 		PF01969
(DUF111) 		4 HIS A  42
CYH A  41
HIS A  55
LEU A  57
 PO4  A 185 (-4.2A)
None
None
None
 1.33A 5hrqD-3c19A:
undetectable
5hrqG-3c19A:
undetectable
5hrqH-3c19A:
undetectable		 5hrqD-3c19A:
12.69
5hrqG-3c19A:
5.81
5hrqH-3c19A:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c7j TRANSCRIPTIONAL
REGULATOR, GNTR
FAMILY

(Pseudomonas
syringae group
genomosp. 3) 		PF00392
(GntR)
PF07729
(FCD) 		4 HIS A 214
LEU A 215
CYH A 207
LEU A 109
 NI  A 301 (-3.4A)
None
None
None
 1.42A 5hrqD-3c7jA:
undetectable
5hrqG-3c7jA:
undetectable
5hrqH-3c7jA:
undetectable		 5hrqD-3c7jA:
10.31
5hrqG-3c7jA:
10.45
5hrqH-3c7jA:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dxn CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3

(Toxoplasma
gondii) 		PF00069
(Pkinase) 		4 HIS A 138
LEU A 137
CYH A 203
LEU A 147
 None
 1.41A 5hrqD-3dxnA:
undetectable
5hrqG-3dxnA:
undetectable
5hrqH-3dxnA:
undetectable		 5hrqD-3dxnA:
6.71
5hrqG-3dxnA:
4.96
5hrqH-3dxnA:
6.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ebj POLYMERASE ACIDIC
PROTEIN

(Influenza A
virus) 		PF00603
(Flu_PA) 		4 HIS A 146
LEU A 163
CYH A  45
LEU A 109
 None
 1.27A 5hrqD-3ebjA:
undetectable
5hrqG-3ebjA:
undetectable
5hrqH-3ebjA:
undetectable		 5hrqD-3ebjA:
8.64
5hrqG-3ebjA:
6.64
5hrqH-3ebjA:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f5x CYCLIN-A2

(Homo sapiens) 		PF00134
(Cyclin_N)
PF02984
(Cyclin_C) 		4 LEU B 430
CYH B 390
HIS B 395
LEU B 394
 None
 1.37A 5hrqD-3f5xB:
undetectable
5hrqG-3f5xB:
undetectable
5hrqH-3f5xB:
undetectable		 5hrqD-3f5xB:
7.51
5hrqG-3f5xB:
7.34
5hrqH-3f5xB:
7.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hcs TNF
RECEPTOR-ASSOCIATED
FACTOR 6

(Homo sapiens) 		PF13923
(zf-C3HC4_2) 		4 LEU A  64
CYH A  70
CYH A  73
LEU A  77
 None
ZN  A 301 (-2.5A)
ZN  A 301 (-2.4A)
None
 1.34A 5hrqD-3hcsA:
undetectable
5hrqG-3hcsA:
undetectable
5hrqH-3hcsA:
undetectable		 5hrqD-3hcsA:
14.89
5hrqG-3hcsA:
11.27
5hrqH-3hcsA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF10

(Schizosaccharomyces
pombe) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF16004
(EFTUD2) 		4 HIS B 220
LEU B 150
CYH B 911
HIS B 151
 None
None
None
GDP  B1000 ( 4.8A)
 1.41A 5hrqD-3jb9B:
undetectable
5hrqG-3jb9B:
undetectable
5hrqH-3jb9B:
undetectable		 5hrqD-3jb9B:
2.65
5hrqG-3jb9B:
3.57
5hrqH-3jb9B:
2.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kv4 PHD FINGER PROTEIN 8

(Homo sapiens) 		PF00628
(PHD)
PF02373
(JmjC) 		4 HIS A  49
LEU A  47
CYH A  26
CYH A  53
 None
None
ZN  A 449 (-1.9A)
ZN  A 449 (-2.4A)
 1.45A 5hrqD-3kv4A:
undetectable
5hrqG-3kv4A:
undetectable
5hrqH-3kv4A:
undetectable		 5hrqD-3kv4A:
5.29
5hrqG-3kv4A:
4.33
5hrqH-3kv4A:
5.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpm PUTATIVE
METHYLTRANSFERASE

(Listeria
monocytogenes) 		PF05175
(MTS) 		4 LEU A 165
CYH A  57
CYH A 125
LEU A 108
 None
 1.42A 5hrqD-3lpmA:
undetectable
5hrqG-3lpmA:
undetectable
5hrqH-3lpmA:
undetectable		 5hrqD-3lpmA:
9.72
5hrqG-3lpmA:
8.95
5hrqH-3lpmA:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwm PUTATIVE METAL
UPTAKE REGULATION
PROTEIN

(Streptomyces
coelicolor) 		PF01475
(FUR) 		4 LEU A  67
CYH A  90
CYH A  93
HIS A  87
 None
ZN  A 140 (-2.3A)
ZN  A 140 (-2.2A)
ZN  A 141 (-3.1A)
 1.29A 5hrqD-3mwmA:
undetectable
5hrqG-3mwmA:
undetectable
5hrqH-3mwmA:
undetectable		 5hrqD-3mwmA:
15.38
5hrqG-3mwmA:
8.70
5hrqH-3mwmA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o5a PERIPLASMIC NITRATE
REDUCTASE
DIHEME CYTOCHROME C
NAPB

(Cupriavidus
necator;
Cupriavidus
necator) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4)
PF03892
(NapB) 		4 LEU A 711
CYH B 101
HIS A 698
LEU A 696
 None
HEC  B1129 (-2.1A)
None
None
 1.41A 5hrqD-3o5aA:
undetectable
5hrqG-3o5aA:
undetectable
5hrqH-3o5aA:
undetectable		 5hrqD-3o5aA:
3.25
5hrqG-3o5aA:
3.88
5hrqH-3o5aA:
3.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L

(Homo sapiens) 		PF00856
(SET) 		4 HIS A2258
LEU A2196
CYH A2224
LEU A2239
 None
 1.41A 5hrqD-3opeA:
undetectable
5hrqG-3opeA:
undetectable
5hrqH-3opeA:
undetectable		 5hrqD-3opeA:
16.98
5hrqG-3opeA:
8.14
5hrqH-3opeA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qyb TBC1 DOMAIN FAMILY
MEMBER 4

(Homo sapiens) 		PF00566
(RabGAP-TBC) 		4 HIS A1073
LEU A1070
CYH A1135
LEU A1145
 None
 1.05A 5hrqD-3qybA:
undetectable
5hrqG-3qybA:
undetectable
5hrqH-3qybA:
undetectable		 5hrqD-3qybA:
6.51
5hrqG-3qybA:
5.56
5hrqH-3qybA:
6.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r7w GTP-BINDING PROTEIN
GTR2

(Saccharomyces
cerevisiae) 		PF04670
(Gtr1_RagA) 		4 HIS B 124
LEU B 122
CYH B  26
LEU B  14
 GNP  B 500 (-3.7A)
None
None
None
 1.40A 5hrqD-3r7wB:
undetectable
5hrqG-3r7wB:
undetectable
5hrqH-3r7wB:
undetectable		 5hrqD-3r7wB:
5.54
5hrqG-3r7wB:
5.70
5hrqH-3r7wB:
5.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3two MANNITOL
DEHYDROGENASE

(Helicobacter
pylori) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 HIS A  47
LEU A 266
CYH A  42
LEU A 188
 NDP  A 601 (-4.0A)
NDP  A 601 (-4.7A)
ZN  A 350 ( 2.5A)
NDP  A 601 (-3.5A)
 1.49A 5hrqD-3twoA:
undetectable
5hrqG-3twoA:
undetectable
5hrqH-3twoA:
undetectable		 5hrqD-3twoA:
8.71
5hrqG-3twoA:
5.52
5hrqH-3twoA:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umc HALOACID
DEHALOGENASE

(Pseudomonas
aeruginosa) 		PF13419
(HAD_2) 		4 HIS A  68
LEU A 127
HIS A  96
LEU A  98
 None
 1.32A 5hrqD-3umcA:
undetectable
5hrqG-3umcA:
undetectable
5hrqH-3umcA:
undetectable		 5hrqD-3umcA:
9.23
5hrqG-3umcA:
6.93
5hrqH-3umcA:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umg HALOACID
DEHALOGENASE

(Rhodococcus
jostii) 		PF00702
(Hydrolase) 		4 HIS A  82
LEU A 144
HIS A 113
LEU A 115
 None
 1.35A 5hrqD-3umgA:
undetectable
5hrqG-3umgA:
undetectable
5hrqH-3umgA:
undetectable		 5hrqD-3umgA:
10.24
5hrqG-3umgA:
10.34
5hrqH-3umgA:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 HIS A2270
LEU A2387
CYH A2411
LEU A2367
 None
 1.03A 5hrqD-3vkgA:
undetectable
5hrqG-3vkgA:
undetectable
5hrqH-3vkgA:
undetectable		 5hrqD-3vkgA:
1.34
5hrqG-3vkgA:
0.68
5hrqH-3vkgA:
1.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zvz E3 UBIQUITIN-PROTEIN
LIGASE UHRF1

(Homo sapiens) 		PF00628
(PHD) 		4 HIS B 319
LEU B 320
CYH B 333
CYH B 336
 None
None
ZN  B 434 (-2.3A)
ZN  B 434 (-2.3A)
 1.38A 5hrqD-3zvzB:
undetectable
5hrqG-3zvzB:
undetectable
5hrqH-3zvzB:
undetectable		 5hrqD-3zvzB:
20.75
5hrqG-3zvzB:
18.18
5hrqH-3zvzB:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4awm POLYMERASE PA

(Influenza A
virus) 		PF00603
(Flu_PA) 		4 HIS A 146
LEU A 163
CYH A  45
LEU A 109
 None
 1.20A 5hrqD-4awmA:
undetectable
5hrqG-4awmA:
undetectable
5hrqH-4awmA:
undetectable		 5hrqD-4awmA:
11.39
5hrqG-4awmA:
11.63
5hrqH-4awmA:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1n CARBON MONOXIDE
DEHYDROGENASE
CORRINOID/IRON-SULFU
R PROTEIN, GAMMA
SUBUNIT

(Carboxydothermus
hydrogenoformans) 		PF03599
(CdhD)
PF04060
(FeS) 		4 LEU A  53
CYH A  42
HIS A  11
LEU A  12
 None
SF4  A1444 (-2.3A)
None
SF4  A1444 ( 4.5A)
 1.38A 5hrqD-4c1nA:
undetectable
5hrqG-4c1nA:
undetectable
5hrqH-4c1nA:
undetectable		 5hrqD-4c1nA:
7.37
5hrqG-4c1nA:
3.76
5hrqH-4c1nA:
7.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4flc ADENYLOSUCCINATE
LYASE

(Homo sapiens) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		4 HIS A 310
LEU A 311
CYH A 340
LEU A 252
 None
 1.50A 5hrqD-4flcA:
undetectable
5hrqG-4flcA:
undetectable
5hrqH-4flcA:
undetectable		 5hrqD-4flcA:
6.20
5hrqG-4flcA:
3.49
5hrqH-4flcA:
6.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g25 PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL

(Arabidopsis
thaliana) 		PF16953
(PRORP)
PF17177
(PPR_long) 		4 LEU A 100
CYH A 107
HIS A 134
LEU A 138
 None
 1.15A 5hrqD-4g25A:
undetectable
5hrqG-4g25A:
undetectable
5hrqH-4g25A:
undetectable		 5hrqD-4g25A:
5.84
5hrqG-4g25A:
3.80
5hrqH-4g25A:
5.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gmf YERSINIABACTIN
BIOSYNTHETIC PROTEIN
YBTU

(Yersinia
enterocolitica) 		PF01408
(GFO_IDH_MocA) 		4 HIS A 308
LEU A 309
CYH A 318
HIS A  96
 None
 1.26A 5hrqD-4gmfA:
undetectable
5hrqG-4gmfA:
undetectable
5hrqH-4gmfA:
undetectable		 5hrqD-4gmfA:
5.93
5hrqG-4gmfA:
5.22
5hrqH-4gmfA:
5.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpp PROBABLE GLUTAMINE
SYNTHETASE

(Pseudomonas
aeruginosa) 		PF00120
(Gln-synt_C)
PF16952
(Gln-synt_N_2) 		4 HIS A 273
LEU A 277
CYH A 405
LEU A 398
 None
 1.39A 5hrqD-4hppA:
undetectable
5hrqG-4hppA:
undetectable
5hrqH-4hppA:
undetectable		 5hrqD-4hppA:
5.80
5hrqG-4hppA:
3.82
5hrqH-4hppA:
5.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hx6 OXIDOREDUCTASE

(Streptomyces
globisporus) 		PF01613
(Flavin_Reduct) 		4 LEU A 122
CYH A 132
HIS A 129
LEU A 130
 None
 1.37A 5hrqD-4hx6A:
undetectable
5hrqG-4hx6A:
undetectable
5hrqH-4hx6A:
undetectable		 5hrqD-4hx6A:
11.11
5hrqG-4hx6A:
7.53
5hrqH-4hx6A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7m PROTEIN DOM3Z

(Mus musculus) 		PF08652
(RAI1) 		4 LEU A 151
CYH A 331
HIS A 134
LEU A 135
 None
 1.46A 5hrqD-4j7mA:
undetectable
5hrqG-4j7mA:
undetectable
5hrqH-4j7mA:
undetectable		 5hrqD-4j7mA:
5.34
5hrqG-4j7mA:
4.68
5hrqH-4j7mA:
5.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jqp 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE

(Paraburkholderia
phymatum) 		PF04166
(PdxA) 		4 LEU A 329
CYH A  46
HIS A  39
LEU A  37
 None
 1.22A 5hrqD-4jqpA:
undetectable
5hrqG-4jqpA:
undetectable
5hrqH-4jqpA:
undetectable		 5hrqD-4jqpA:
7.69
5hrqG-4jqpA:
5.73
5hrqH-4jqpA:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k49 ESTERASE YDII

(Escherichia
coli) 		no annotation 4 HIS C  89
CYH C 126
HIS C  54
LEU C  53
 HFQ  C 201 (-4.1A)
None
HFQ  C 201 (-3.7A)
None
 1.47A 5hrqD-4k49C:
undetectable
5hrqG-4k49C:
undetectable
5hrqH-4k49C:
undetectable		 5hrqD-4k49C:
17.24
5hrqG-4k49C:
11.36
5hrqH-4k49C:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k4d PROOFREADING
THIOESTERASE ENTH

(Escherichia
coli) 		PF03061
(4HBT) 		4 HIS A  89
CYH A 126
HIS A  54
LEU A  53
 HFQ  A 201 (-4.2A)
None
HFQ  A 201 (-3.2A)
None
 1.37A 5hrqD-4k4dA:
undetectable
5hrqG-4k4dA:
undetectable
5hrqH-4k4dA:
undetectable		 5hrqD-4k4dA:
14.29
5hrqG-4k4dA:
8.70
5hrqH-4k4dA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kf9 GLUTATHIONE
S-TRANSFERASE
PROTEIN

(Ralstonia
solanacearum) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		4 HIS A   9
LEU A   8
CYH A  66
HIS A  10
 None
 1.27A 5hrqD-4kf9A:
undetectable
5hrqG-4kf9A:
undetectable
5hrqH-4kf9A:
undetectable		 5hrqD-4kf9A:
6.77
5hrqG-4kf9A:
4.26
5hrqH-4kf9A:
6.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ldq METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE

(Homo sapiens) 		PF01008
(IF-2B) 		4 HIS A 196
LEU A 194
CYH A 199
LEU A 216
 None
 0.96A 5hrqD-4ldqA:
undetectable
5hrqG-4ldqA:
undetectable
5hrqH-4ldqA:
undetectable		 5hrqD-4ldqA:
6.54
5hrqG-4ldqA:
5.82
5hrqH-4ldqA:
6.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m5o POLYMERASE PA

(Influenza A
virus) 		PF00603
(Flu_PA) 		4 HIS A 146
LEU A 163
CYH A  45
LEU A 109
 None
 1.20A 5hrqD-4m5oA:
undetectable
5hrqG-4m5oA:
undetectable
5hrqH-4m5oA:
undetectable		 5hrqD-4m5oA:
11.76
5hrqG-4m5oA:
9.62
5hrqH-4m5oA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mlg BETA-XYLOSIDASE

(uncultured
organism) 		PF04616
(Glyco_hydro_43) 		4 HIS A 275
LEU A 286
CYH A 247
HIS A 288
 None
 1.25A 5hrqD-4mlgA:
undetectable
5hrqG-4mlgA:
undetectable
5hrqH-4mlgA:
undetectable		 5hrqD-4mlgA:
7.55
5hrqG-4mlgA:
5.43
5hrqH-4mlgA:
7.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mlg BETA-XYLOSIDASE

(uncultured
organism) 		PF04616
(Glyco_hydro_43) 		4 HIS A 275
LEU A 286
CYH A 247
HIS A 288
 None
 1.37A 5hrqD-4mlgA:
undetectable
5hrqG-4mlgA:
undetectable
5hrqH-4mlgA:
undetectable		 5hrqD-4mlgA:
7.55
5hrqG-4mlgA:
5.43
5hrqH-4mlgA:
7.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2

(Plasmodium
falciparum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 HIS A 184
LEU A 183
CYH A 249
LEU A 193
 None
 1.24A 5hrqD-4mvfA:
undetectable
5hrqG-4mvfA:
undetectable
5hrqH-4mvfA:
undetectable		 5hrqD-4mvfA:
4.61
5hrqG-4mvfA:
5.15
5hrqH-4mvfA:
4.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mwf FAB AR3C HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 HIS A  79
CYH A  92
CYH A  22
LEU A  34
 None
 1.21A 5hrqD-4mwfA:
undetectable
5hrqG-4mwfA:
undetectable
5hrqH-4mwfA:
undetectable		 5hrqD-4mwfA:
10.18
5hrqG-4mwfA:
6.60
5hrqH-4mwfA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nfz POLYMERASE PA

(Influenza A
virus) 		PF00603
(Flu_PA) 		4 HIS A 146
LEU A 163
CYH A  45
LEU A 109
 None
 1.34A 5hrqD-4nfzA:
undetectable
5hrqG-4nfzA:
undetectable
5hrqH-4nfzA:
undetectable		 5hrqD-4nfzA:
12.61
5hrqG-4nfzA:
13.11
5hrqH-4nfzA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7a HISTONE-BINDING
PROTEIN RBBP4

(Homo sapiens) 		PF00400
(WD40)
PF12265
(CAF1C_H4-bd) 		4 LEU B  86
CYH B 391
HIS B  64
LEU B  66
 None
 1.41A 5hrqD-4r7aB:
undetectable
5hrqG-4r7aB:
undetectable
5hrqH-4r7aB:
undetectable		 5hrqD-4r7aB:
10.28
5hrqG-4r7aB:
3.97
5hrqH-4r7aB:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ruw ENDONUCLEASE/EXONUCL
EASE/PHOSPHATASE

(Beutenbergia
cavernae) 		PF03372
(Exo_endo_phos) 		4 HIS A 194
LEU A 178
HIS A 220
LEU A 218
 None
 1.14A 5hrqD-4ruwA:
undetectable
5hrqG-4ruwA:
undetectable
5hrqH-4ruwA:
undetectable		 5hrqD-4ruwA:
4.90
5hrqG-4ruwA:
3.26
5hrqH-4ruwA:
4.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yk3 BEPE PROTEIN

(Bartonella
henselae) 		no annotation 4 HIS A 165
CYH A 167
HIS A 230
LEU A 231
 None
 1.33A 5hrqD-4yk3A:
undetectable
5hrqG-4yk3A:
undetectable
5hrqH-4yk3A:
undetectable		 5hrqD-4yk3A:
13.01
5hrqG-4yk3A:
11.22
5hrqH-4yk3A:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr0 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		4 LEU A 281
CYH A 325
HIS A 331
LEU A 329
 None
 1.49A 5hrqD-4zr0A:
undetectable
5hrqG-4zr0A:
undetectable
5hrqH-4zr0A:
undetectable		 5hrqD-4zr0A:
9.23
5hrqG-4zr0A:
4.90
5hrqH-4zr0A:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		4 LEU A 281
CYH A 325
HIS A 331
LEU A 329
 None
BOG  A 405 ( 4.9A)
None
None
 1.48A 5hrqD-4zr1A:
undetectable
5hrqG-4zr1A:
undetectable
5hrqH-4zr1A:
undetectable		 5hrqD-4zr1A:
9.23
5hrqG-4zr1A:
5.04
5hrqH-4zr1A:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b16 RIBONUCLEASE
3,DROSHA,RIBONUCLEAS
E
3,DROSHA,RIBONUCLEAS
E 3

(Homo sapiens) 		PF00035
(dsrm)
PF00636
(Ribonuclease_3)
PF14622
(Ribonucleas_3_3) 		4 HIS A1120
LEU A1123
HIS A1084
LEU A1083
 None
 1.14A 5hrqD-5b16A:
undetectable
5hrqG-5b16A:
undetectable
5hrqH-5b16A:
undetectable		 5hrqD-5b16A:
3.92
5hrqG-5b16A:
2.54
5hrqH-5b16A:
3.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5diz PROTEINACEOUS RNASE
P 2

(Arabidopsis
thaliana) 		PF16953
(PRORP)
PF17177
(PPR_long) 		4 LEU A  33
CYH A  40
HIS A  68
LEU A  72
 None
 1.30A 5hrqD-5dizA:
undetectable
5hrqG-5dizA:
undetectable
5hrqH-5dizA:
undetectable		 5hrqD-5dizA:
4.75
5hrqG-5dizA:
5.36
5hrqH-5dizA:
4.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF09334
(tRNA-synt_1g) 		4 HIS A 793
LEU A 773
CYH A 787
LEU A 244
 None
 1.50A 5hrqD-5gl7A:
undetectable
5hrqG-5gl7A:
undetectable
5hrqH-5gl7A:
undetectable		 5hrqD-5gl7A:
3.79
5hrqG-5gl7A:
4.15
5hrqH-5gl7A:
3.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5irm UNCHARACTERIZED
PROTEIN

(Oryctolagus
cuniculus) 		PF05729
(NACHT)
PF13516
(LRR_6) 		4 HIS A 440
LEU A 436
CYH A 475
LEU A 479
 None
 1.48A 5hrqD-5irmA:
undetectable
5hrqG-5irmA:
undetectable
5hrqH-5irmA:
undetectable		 5hrqD-5irmA:
3.36
5hrqG-5irmA:
2.25
5hrqH-5irmA:
3.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mjs TUBULIN BETA CHAIN

(Schizosaccharomyces
pombe) 		no annotation 4 HIS A  44
LEU A  47
HIS A  28
LEU A  30
 None
 0.78A 5hrqD-5mjsA:
undetectable
5hrqG-5mjsA:
undetectable
5hrqH-5mjsA:
undetectable		 5hrqD-5mjsA:
undetectable
5hrqG-5mjsA:
undetectable
5hrqH-5mjsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nr1 FTSZ-BINDING PROTEIN
FZLA

(Caulobacter
vibrioides) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		4 HIS A   8
LEU A   7
CYH A  68
HIS A   9
 None
 1.27A 5hrqD-5nr1A:
undetectable
5hrqG-5nr1A:
undetectable
5hrqH-5nr1A:
undetectable		 5hrqD-5nr1A:
11.45
5hrqG-5nr1A:
6.31
5hrqH-5nr1A:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ny5 3,4-DIHYDROXYBENZOAT
E DECARBOXYLASE

(Enterobacter
cloacae) 		PF01977
(UbiD) 		4 HIS A 327
LEU A 330
CYH A 150
LEU A 320
 None
 1.47A 5hrqD-5ny5A:
undetectable
5hrqG-5ny5A:
undetectable
5hrqH-5ny5A:
undetectable		 5hrqD-5ny5A:
4.65
5hrqG-5ny5A:
4.26
5hrqH-5ny5A:
4.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o3m PROTOCATECHUATE
DECARBOXYLASE

(Klebsiella
pneumoniae) 		PF01977
(UbiD) 		4 HIS A 327
LEU A 330
CYH A 150
LEU A 320
 9JE  A 601 (-4.3A)
9JE  A 601 ( 4.3A)
None
None
 1.45A 5hrqD-5o3mA:
undetectable
5hrqG-5o3mA:
undetectable
5hrqH-5o3mA:
undetectable		 5hrqD-5o3mA:
4.59
5hrqG-5o3mA:
3.70
5hrqH-5o3mA:
4.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5td7 ZGC:55652

(Danio rerio) 		PF00850
(Hist_deacetyl) 		4 HIS A 433
LEU A 427
CYH A 485
LEU A 625
 None
 1.46A 5hrqD-5td7A:
undetectable
5hrqG-5td7A:
undetectable
5hrqH-5td7A:
undetectable		 5hrqD-5td7A:
3.77
5hrqG-5td7A:
2.85
5hrqH-5td7A:
3.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tf2 PROLACTIN REGULATORY
ELEMENT-BINDING
PROTEIN

(Homo sapiens) 		PF00400
(WD40) 		4 HIS A 381
LEU A 369
CYH A 378
LEU A  19
 None
 1.47A 5hrqD-5tf2A:
undetectable
5hrqG-5tf2A:
undetectable
5hrqH-5tf2A:
undetectable		 5hrqD-5tf2A:
5.59
5hrqG-5tf2A:
6.40
5hrqH-5tf2A:
5.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ve8 KAP123

(Kluyveromyces
lactis) 		no annotation 4 LEU A 757
CYH A 801
HIS A 796
LEU A 797
 None
 1.19A 5hrqD-5ve8A:
undetectable
5hrqG-5ve8A:
undetectable
5hrqH-5ve8A:
undetectable		 5hrqD-5ve8A:
2.49
5hrqG-5ve8A:
1.84
5hrqH-5ve8A:
2.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vnz TNF
RECEPTOR-ASSOCIATED
FACTOR 6

(Danio rerio) 		no annotation 4 LEU A  65
CYH A  71
CYH A  74
LEU A  78
 None
ZN  A 201 (-2.3A)
ZN  A 201 (-2.3A)
None
 1.35A 5hrqD-5vnzA:
undetectable
5hrqG-5vnzA:
undetectable
5hrqH-5vnzA:
undetectable		 5hrqD-5vnzA:
undetectable
5hrqG-5vnzA:
undetectable
5hrqH-5vnzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vo0 TNF
RECEPTOR-ASSOCIATED
FACTOR 6

(Danio rerio) 		no annotation 4 LEU A  65
CYH A  71
CYH A  74
LEU A  78
 None
ZN  A 301 (-2.3A)
ZN  A 301 (-2.3A)
None
 1.34A 5hrqD-5vo0A:
undetectable
5hrqG-5vo0A:
undetectable
5hrqH-5vo0A:
undetectable		 5hrqD-5vo0A:
undetectable
5hrqG-5vo0A:
undetectable
5hrqH-5vo0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w81 CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR

(Danio rerio) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane)
PF14396
(CFTR_R) 		4 LEU A 577
CYH A 523
CYH A 589
LEU A 557
 None
 1.38A 5hrqD-5w81A:
undetectable
5hrqG-5w81A:
undetectable
5hrqH-5w81A:
undetectable		 5hrqD-5w81A:
3.62
5hrqG-5w81A:
1.71
5hrqH-5w81A:
3.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ayv FRUCTOSE-1,6-BISPHOS
PHATASE CLASS 2

(Mycobacterium
tuberculosis) 		no annotation 4 HIS A 162
LEU A 165
CYH A 155
LEU A 200
 None
GOL  A 404 ( 4.8A)
None
None
 1.41A 5hrqD-6ayvA:
undetectable
5hrqG-6ayvA:
undetectable
5hrqH-6ayvA:
undetectable		 5hrqD-6ayvA:
undetectable
5hrqG-6ayvA:
undetectable
5hrqH-6ayvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ewl CENTROSOMAL PROTEIN
120

(Danio rerio) 		no annotation 4 LEU A  97
CYH A  79
HIS A 112
LEU A 126
 None
 1.28A 5hrqD-6ewlA:
undetectable
5hrqG-6ewlA:
undetectable
5hrqH-6ewlA:
undetectable		 5hrqD-6ewlA:
undetectable
5hrqG-6ewlA:
undetectable
5hrqH-6ewlA:
undetectable