SIMILAR PATTERNS OF AMINO ACIDS FOR 5HRQ_C_IPHC101_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ecg GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Escherichia
coli) 		PF00156
(Pribosyltran)
PF13522
(GATase_6) 		4 CYH A 169
ILE A   3
LEU A  98
HIS A  71
 None
 1.45A 5hrqC-1ecgA:
undetectable
5hrqD-1ecgA:
undetectable
5hrqL-1ecgA:
undetectable		 5hrqC-1ecgA:
3.39
5hrqD-1ecgA:
7.57
5hrqL-1ecgA:
7.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1la2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE

(Saccharomyces
cerevisiae) 		PF01658
(Inos-1-P_synth)
PF07994
(NAD_binding_5) 		4 CYH A 202
ILE A 185
LEU A 205
HIS A 219
 None
 0.71A 5hrqC-1la2A:
undetectable
5hrqD-1la2A:
undetectable
5hrqL-1la2A:
undetectable		 5hrqC-1la2A:
3.71
5hrqD-1la2A:
7.10
5hrqL-1la2A:
7.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mda METHYLAMINE
DEHYDROGENASE (HEAVY
SUBUNIT)

(Paracoccus
denitrificans) 		PF06433
(Me-amine-dh_H) 		4 CYH H 167
CYH H 183
LEU H 180
HIS H 169
 None
 1.45A 5hrqC-1mdaH:
undetectable
5hrqD-1mdaH:
undetectable
5hrqL-1mdaH:
undetectable		 5hrqC-1mdaH:
9.77
5hrqD-1mdaH:
7.69
5hrqL-1mdaH:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nq7 NUCLEAR RECEPTOR
ROR-BETA

(Rattus
norvegicus) 		PF00104
(Hormone_recep) 		4 CYH A 262
ILE A 266
LEU A 333
HIS A 423
 ARL  A 800 (-3.5A)
None
None
ARL  A 800 ( 4.3A)
 1.40A 5hrqC-1nq7A:
undetectable
5hrqD-1nq7A:
undetectable
5hrqL-1nq7A:
undetectable		 5hrqC-1nq7A:
5.61
5hrqD-1nq7A:
10.81
5hrqL-1nq7A:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pwe L-SERINE DEHYDRATASE

(Rattus
norvegicus) 		PF00291
(PALP) 		4 CYH A 270
ILE A 301
CYH A 303
LEU A 274
 None
 1.39A 5hrqC-1pweA:
undetectable
5hrqD-1pweA:
undetectable
5hrqL-1pweA:
undetectable		 5hrqC-1pweA:
4.29
5hrqD-1pweA:
6.92
5hrqL-1pweA:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1raj GENOME POLYPROTEIN

(Enterovirus C) 		PF00680
(RdRP_1) 		4 CYH A 418
ILE A 397
LEU A 433
HIS A 398
 None
 1.39A 5hrqC-1rajA:
undetectable
5hrqD-1rajA:
undetectable
5hrqL-1rajA:
undetectable		 5hrqC-1rajA:
6.88
5hrqD-1rajA:
9.48
5hrqL-1rajA:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ta9 GLYCEROL
DEHYDROGENASE

(Schizosaccharomyces
pombe) 		PF00465
(Fe-ADH) 		4 CYH A 365
ILE A 448
LEU A 367
HIS A 444
 None
 1.43A 5hrqC-1ta9A:
undetectable
5hrqD-1ta9A:
undetectable
5hrqL-1ta9A:
undetectable		 5hrqC-1ta9A:
4.21
5hrqD-1ta9A:
5.41
5hrqL-1ta9A:
5.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5v CITE

(Mycobacterium
tuberculosis) 		PF03328
(HpcH_HpaI) 		4 CYH A 208
ILE A 185
LEU A  11
HIS A 210
 None
 1.40A 5hrqC-1u5vA:
undetectable
5hrqD-1u5vA:
undetectable
5hrqL-1u5vA:
undetectable		 5hrqC-1u5vA:
3.75
5hrqD-1u5vA:
7.97
5hrqL-1u5vA:
7.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ecw TRIPARTITE
MOTIF-CONTAINING
PROTEIN 30

(Mus musculus) 		PF13445
(zf-RING_UBOX) 		4 CYH A  42
ILE A  46
CYH A  45
LEU A  29
 ZN  A 201 ( 2.3A)
None
ZN  A 201 ( 2.1A)
None
 1.43A 5hrqC-2ecwA:
undetectable
5hrqD-2ecwA:
undetectable
5hrqL-2ecwA:
undetectable		 5hrqC-2ecwA:
13.70
5hrqD-2ecwA:
14.47
5hrqL-2ecwA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2egp TRIPARTITE
MOTIF-CONTAINING
PROTEIN 34

(Homo sapiens) 		PF13445
(zf-RING_UBOX) 		4 CYH A  35
ILE A  39
CYH A  38
LEU A  22
 ZN  A 200 (-2.2A)
None
ZN  A 200 (-2.2A)
None
 1.39A 5hrqC-2egpA:
undetectable
5hrqD-2egpA:
undetectable
5hrqL-2egpA:
undetectable		 5hrqC-2egpA:
13.92
5hrqD-2egpA:
13.92
5hrqL-2egpA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gez L-ASPARAGINASE ALPHA
SUBUNIT
L-ASPARAGINASE BETA
SUBUNIT

(Lupinus luteus;
Lupinus luteus) 		PF01112
(Asparaginase_2)
PF01112
(Asparaginase_2) 		4 ILE B 289
CYH B 196
LEU A  59
HIS A   9
 None
 1.14A 5hrqC-2gezB:
undetectable
5hrqD-2gezB:
undetectable
5hrqL-2gezB:
undetectable		 5hrqC-2gezB:
19.51
5hrqD-2gezB:
12.03
5hrqL-2gezB:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ot3 RAS-RELATED PROTEIN
RAB-21

(Homo sapiens) 		PF00071
(Ras) 		4 ILE B 129
CYH B 128
LEU B 172
HIS B 158
 None
 1.46A 5hrqC-2ot3B:
undetectable
5hrqD-2ot3B:
undetectable
5hrqL-2ot3B:
undetectable		 5hrqC-2ot3B:
7.27
5hrqD-2ot3B:
14.29
5hrqL-2ot3B:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pvc DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3-LIKE

(Homo sapiens) 		no annotation 4 CYH B  56
ILE B  54
CYH B  53
HIS B  65
 ZN  B 604 (-2.2A)
None
ZN  B 604 (-2.1A)
None
 1.47A 5hrqC-2pvcB:
undetectable
5hrqD-2pvcB:
undetectable
5hrqL-2pvcB:
undetectable		 5hrqC-2pvcB:
7.12
5hrqD-2pvcB:
7.47
5hrqL-2pvcB:
7.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rkb SERINE
DEHYDRATASE-LIKE

(Homo sapiens) 		PF00291
(PALP) 		4 CYH A 276
ILE A 307
CYH A 309
LEU A 280
 None
None
PLP  A 400 (-3.6A)
None
 1.48A 5hrqC-2rkbA:
undetectable
5hrqD-2rkbA:
undetectable
5hrqL-2rkbA:
undetectable		 5hrqC-2rkbA:
5.28
5hrqD-2rkbA:
9.09
5hrqL-2rkbA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwu IMPORTIN13

(Homo sapiens) 		PF03810
(IBN_N)
PF08389
(Xpo1) 		4 CYH B 309
ILE B 340
CYH B 343
LEU B 359
 None
 1.48A 5hrqC-2xwuB:
undetectable
5hrqD-2xwuB:
undetectable
5hrqL-2xwuB:
undetectable		 5hrqC-2xwuB:
3.04
5hrqD-2xwuB:
2.65
5hrqL-2xwuB:
2.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1b DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A,
HISTONE H3.1

(Homo sapiens) 		no annotation 4 CYH A 497
ILE A 495
CYH A 494
HIS A 506
 ZN  A   1 (-2.3A)
None
ZN  A   1 (-2.2A)
None
 1.44A 5hrqC-3a1bA:
undetectable
5hrqD-3a1bA:
undetectable
5hrqL-3a1bA:
undetectable		 5hrqC-3a1bA:
16.47
5hrqD-3a1bA:
9.43
5hrqL-3a1bA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8k DIHYDROLIPOYLLYSINE-
RESIDUE
ACETYLTRANSFERASE

(Homo sapiens) 		PF00198
(2-oxoacid_dh) 		4 ILE A 493
CYH A 500
LEU A 530
HIS A 359
 None
 1.50A 5hrqC-3b8kA:
undetectable
5hrqD-3b8kA:
undetectable
5hrqL-3b8kA:
undetectable		 5hrqC-3b8kA:
5.51
5hrqD-3b8kA:
8.44
5hrqL-3b8kA:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f0w NUMB-LIKE PROTEIN

(Homo sapiens) 		PF00640
(PID) 		4 ILE A 170
CYH A 171
LEU A 106
HIS A  87
 None
 1.33A 5hrqC-3f0wA:
undetectable
5hrqD-3f0wA:
undetectable
5hrqL-3f0wA:
undetectable		 5hrqC-3f0wA:
11.21
5hrqD-3f0wA:
9.15
5hrqL-3f0wA:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcx S-FORMYLGLUTATHIONE
HYDROLASE

(Homo sapiens) 		PF00756
(Esterase) 		4 ILE A 157
CYH A 158
LEU A  51
HIS A 153
 MG  A 283 ( 4.9A)
None
None
MG  A 283 (-3.7A)
 1.48A 5hrqC-3fcxA:
undetectable
5hrqD-3fcxA:
undetectable
5hrqL-3fcxA:
undetectable		 5hrqC-3fcxA:
5.34
5hrqD-3fcxA:
17.24
5hrqL-3fcxA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sql GLYCOSYL HYDROLASE
FAMILY 3

(Synechococcus
sp. PCC 7002) 		PF00933
(Glyco_hydro_3) 		4 ILE A 418
CYH A 514
LEU A 445
HIS A 422
 None
 1.21A 5hrqC-3sqlA:
undetectable
5hrqD-3sqlA:
undetectable
5hrqL-3sqlA:
undetectable		 5hrqC-3sqlA:
3.46
5hrqD-3sqlA:
4.76
5hrqL-3sqlA:
4.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uto TWITCHIN

(Caenorhabditis
elegans) 		PF00041
(fn3)
PF00069
(Pkinase)
PF07679
(I-set) 		4 ILE A 402
CYH A 262
LEU A 278
HIS A 269
 None
 1.31A 5hrqC-3utoA:
undetectable
5hrqD-3utoA:
undetectable
5hrqL-3utoA:
undetectable		 5hrqC-3utoA:
3.18
5hrqD-3utoA:
3.22
5hrqL-3utoA:
3.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h0o ACETATE KINASE

(Entamoeba
histolytica) 		PF00871
(Acetate_kinase) 		4 CYH A 197
CYH A 206
LEU A 199
HIS A 172
 None
 1.05A 5hrqC-4h0oA:
undetectable
5hrqD-4h0oA:
undetectable
5hrqL-4h0oA:
undetectable		 5hrqC-4h0oA:
3.98
5hrqD-4h0oA:
7.77
5hrqL-4h0oA:
7.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE

(Homo sapiens) 		PF00291
(PALP) 		4 CYH A 270
ILE A 301
CYH A 303
LEU A 274
 None
None
LLP  A  41 ( 3.2A)
None
 1.44A 5hrqC-4h27A:
undetectable
5hrqD-4h27A:
undetectable
5hrqL-4h27A:
undetectable		 5hrqC-4h27A:
4.63
5hrqD-4h27A:
7.98
5hrqL-4h27A:
7.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jz5 GP26

(Listeria phage
P40) 		PF01183
(Glyco_hydro_25) 		4 CYH A 111
ILE A 115
LEU A 140
HIS A 145
 None
 1.32A 5hrqC-4jz5A:
undetectable
5hrqD-4jz5A:
undetectable
5hrqL-4jz5A:
undetectable		 5hrqC-4jz5A:
7.91
5hrqD-4jz5A:
9.48
5hrqL-4jz5A:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mwf FAB AR3C HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 CYH A  92
CYH A  22
LEU A  34
HIS A  79
 None
 1.34A 5hrqC-4mwfA:
undetectable
5hrqD-4mwfA:
undetectable
5hrqL-4mwfA:
undetectable		 5hrqC-4mwfA:
6.60
5hrqD-4mwfA:
10.18
5hrqL-4mwfA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otp SERINE/THREONINE-PRO
TEIN KINASE RIO1

(Homo sapiens) 		PF01163
(RIO1) 		4 CYH A 264
ILE A 339
LEU A 254
HIS A 322
 None
None
None
PHD  A 341 ( 3.9A)
 1.46A 5hrqC-4otpA:
undetectable
5hrqD-4otpA:
undetectable
5hrqL-4otpA:
undetectable		 5hrqC-4otpA:
4.58
5hrqD-4otpA:
4.83
5hrqL-4otpA:
4.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pu6 L-ASPARAGINASE ALPHA
SUBUNIT
L-ASPARAGINASE BETA
SUBUNIT

(Phaseolus
vulgaris;
Phaseolus
vulgaris) 		PF01112
(Asparaginase_2)
PF01112
(Asparaginase_2) 		4 ILE B 292
CYH B 199
LEU A  58
HIS A   9
 None
 1.13A 5hrqC-4pu6B:
undetectable
5hrqD-4pu6B:
undetectable
5hrqL-4pu6B:
undetectable		 5hrqC-4pu6B:
9.09
5hrqD-4pu6B:
15.00
5hrqL-4pu6B:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u7t DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A

(Homo sapiens) 		PF00145
(DNA_methylase) 		4 CYH A 497
ILE A 495
CYH A 494
HIS A 506
 ZN  A1001 (-2.2A)
None
ZN  A1001 (-2.1A)
None
 1.43A 5hrqC-4u7tA:
undetectable
5hrqD-4u7tA:
undetectable
5hrqL-4u7tA:
undetectable		 5hrqC-4u7tA:
3.60
5hrqD-4u7tA:
7.67
5hrqL-4u7tA:
7.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjs RSA4

(Chaetomium
thermophilum) 		PF00400
(WD40) 		4 CYH A 152
ILE A 149
LEU A 162
HIS A 145
 None
 1.50A 5hrqC-4wjsA:
undetectable
5hrqD-4wjsA:
undetectable
5hrqL-4wjsA:
undetectable		 5hrqC-4wjsA:
3.73
5hrqD-4wjsA:
5.67
5hrqL-4wjsA:
5.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d68 KREV INTERACTION
TRAPPED PROTEIN 1

(Homo sapiens) 		PF00373
(FERM_M)
PF13857
(Ank_5) 		4 ILE A 395
CYH A 396
LEU A 411
HIS A 360
 None
 1.34A 5hrqC-5d68A:
undetectable
5hrqD-5d68A:
undetectable
5hrqL-5d68A:
undetectable		 5hrqC-5d68A:
4.76
5hrqD-5d68A:
7.69
5hrqL-5d68A:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nfh METHIONYL-TRNA
SYNTHETASE, PUTATIVE

(Trypanosoma
brucei) 		no annotation 4 CYH A 470
ILE A 461
LEU A 456
HIS A 289
 None
 1.21A 5hrqC-5nfhA:
undetectable
5hrqD-5nfhA:
undetectable
5hrqL-5nfhA:
undetectable		 5hrqC-5nfhA:
2.99
5hrqD-5nfhA:
4.90
5hrqL-5nfhA:
4.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5njj PROTEIN NUMB HOMOLOG

(Homo sapiens) 		no annotation 4 ILE A 140
CYH A 141
LEU A  65
HIS A  46
 None
 1.37A 5hrqC-5njjA:
undetectable
5hrqD-5njjA:
undetectable
5hrqL-5njjA:
undetectable		 5hrqC-5njjA:
undetectable
5hrqD-5njjA:
undetectable
5hrqL-5njjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u6s UDP-GLYCOSYLTRANSFER
ASE 74F2

(Arabidopsis
thaliana) 		PF00201
(UDPGT) 		4 ILE A 105
CYH A 107
LEU A  34
HIS A   7
 None
 1.29A 5hrqC-5u6sA:
undetectable
5hrqD-5u6sA:
undetectable
5hrqL-5u6sA:
undetectable		 5hrqC-5u6sA:
4.11
5hrqD-5u6sA:
6.69
5hrqL-5u6sA:
6.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vf0 E3 UBIQUITIN-PROTEIN
LIGASE RAD18

(Homo sapiens) 		no annotation 4 CYH B 204
ILE B 211
LEU B 220
HIS B 215
 ZN  B 300 (-2.3A)
None
None
None
 1.22A 5hrqC-5vf0B:
undetectable
5hrqD-5vf0B:
undetectable
5hrqL-5vf0B:
undetectable		 5hrqC-5vf0B:
21.74
5hrqD-5vf0B:
19.57
5hrqL-5vf0B:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fik POLYKETIDE SYNTHASE

(Cercospora
nicotianae) 		no annotation 4 CYH A 809
ILE A 645
LEU A 667
HIS A 561
 None
 1.16A 5hrqC-6fikA:
undetectable
5hrqD-6fikA:
undetectable
5hrqL-6fikA:
undetectable		 5hrqC-6fikA:
undetectable
5hrqD-6fikA:
undetectable
5hrqL-6fikA:
undetectable