SIMILAR PATTERNS OF AMINO ACIDS FOR 5HPW_B_3CJB609_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1d7w MYELOPEROXIDASE

(Homo sapiens) 		PF03098
(An_peroxidase) 		4 GLN A  91
HIS A  95
ARG C 239
ARG C 333
 HEM  A 605 ( 3.4A)
CYN  A1844 (-4.1A)
HEM  A 605 (-4.3A)
HEM  A 605 (-2.9A)
 0.32A 5hpwB-1d7wA:
0.0		 5hpwB-1d7wA:
38.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gjm LACTOPEROXIDASE

(Bubalus bubalis) 		PF03098
(An_peroxidase) 		4 GLN A  91
HIS A  95
ARG A 239
ARG A 333
 HEM  A 605 (-3.4A)
SCN  A1502 ( 4.8A)
HEM  A 605 (-4.7A)
HEM  A 605 (-2.8A)
 0.38A 5hpwB-2gjmA:
59.0		 5hpwB-2gjmA:
95.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k9h 0940_GH29

(unidentified) 		PF00754
(F5_F8_type_C)
PF01120
(Alpha_L_fucos) 		4 GLN A  18
HIS A 401
ARG A 402
ARG A  68
 None
None
GOL  A 606 (-3.3A)
SCN  A 624 ( 3.6A)
 1.26A 5hpwB-5k9hA:
0.0		 5hpwB-5k9hA:
21.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mfa MYELOPEROXIDASE

(Homo sapiens) 		PF03098
(An_peroxidase) 		4 GLN A 257
HIS A 261
ARG A 405
ARG A 499
 HEM  A 812 (-3.3A)
None
HEM  A 812 (-3.7A)
HEM  A 812 (-2.8A)
 0.33A 5hpwB-5mfaA:
53.6		 5hpwB-5mfaA:
49.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6azp MYELOPEROXIDASE

(Homo sapiens) 		no annotation 4 GLN A 257
HIS A 261
ARG A 405
ARG A 499
 None
 0.51A 5hpwB-6azpA:
53.9		 5hpwB-6azpA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6erc PEROXINECTIN A

(Dictyostelium
discoideum) 		no annotation 4 GLN A  97
HIS A 101
ARG A 233
ARG A 322
 HEM  A 604 (-3.4A)
None
HEM  A 604 (-3.1A)
HEM  A 604 (-2.4A)
 0.71A 5hpwB-6ercA:
29.6		 5hpwB-6ercA:
8.99