SIMILAR PATTERNS OF AMINO ACIDS FOR 5HPU_A_IPHA101_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6b GLUTATHIONE
S-TRANSFERASE

(Arabidopsis
thaliana) 		PF13409
(GST_N_2)
PF14497
(GST_C_3) 		4 CYH A 195
LEU A 151
LEU A 171
ALA A 103
 None
 1.07A 5hpuA-1e6bA:
undetectable
5hpuB-1e6bA:
undetectable		 5hpuA-1e6bA:
10.20
5hpuB-1e6bA:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8p MAGNESIUM-CHELATASE
38 KDA SUBUNIT

(Rhodobacter
capsulatus) 		PF01078
(Mg_chelatase) 		4 CYH A 280
LEU A 294
LEU A 323
ALA A 319
 None
 1.11A 5hpuA-1g8pA:
undetectable
5hpuB-1g8pA:
undetectable		 5hpuA-1g8pA:
4.23
5hpuB-1g8pA:
8.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzk RAC-BETA
SERINE/THREONINE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		4 CYH A 345
LEU A 381
LEU A 373
ALA A 377
 None
 0.91A 5hpuA-1gzkA:
undetectable
5hpuB-1gzkA:
undetectable		 5hpuA-1gzkA:
7.94
5hpuB-1gzkA:
8.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iv3 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Thermus
thermophilus) 		PF02542
(YgbB) 		4 CYH A  21
LEU A  96
LEU A 116
ALA A  94
 None
 1.03A 5hpuA-1iv3A:
undetectable
5hpuB-1iv3A:
undetectable		 5hpuA-1iv3A:
6.04
5hpuB-1iv3A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus) 		PF01425
(Amidase) 		4 CYH A 293
LEU A 174
LEU A 134
ALA A 179
 None
 1.11A 5hpuA-1mt5A:
undetectable
5hpuB-1mt5A:
undetectable		 5hpuA-1mt5A:
4.21
5hpuB-1mt5A:
4.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE BETA
SUBUNIT

(Thauera
aromatica) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		4 CYH B 117
LEU B 207
LEU B 190
ALA B 174
 FAD  B1900 (-3.5A)
FAD  B1900 (-4.6A)
None
None
 0.82A 5hpuA-1sb3B:
undetectable
5hpuB-1sb3B:
undetectable		 5hpuA-1sb3B:
6.31
5hpuB-1sb3B:
7.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sfe ADA
O6-METHYLGUANINE-DNA
METHYLTRANSFERASE

(Escherichia
coli) 		PF01035
(DNA_binding_1)
PF02870
(Methyltransf_1N) 		4 CYH A 135
LEU A 118
LEU A 104
ALA A 103
 None
 0.80A 5hpuA-1sfeA:
undetectable
5hpuB-1sfeA:
undetectable		 5hpuA-1sfeA:
10.27
5hpuB-1sfeA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sgv TRNA PSEUDOURIDINE
SYNTHASE B

(Mycobacterium
tuberculosis) 		PF01509
(TruB_N)
PF09142
(TruB_C)
PF16198
(TruB_C_2) 		4 CYH A 232
LEU A 290
LEU A 276
ALA A 288
 None
 0.86A 5hpuA-1sgvA:
undetectable
5hpuB-1sgvA:
undetectable		 5hpuA-1sgvA:
5.71
5hpuB-1sgvA:
7.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tj7 ARGININOSUCCINATE
LYASE

(Escherichia
coli) 		PF00206
(Lyase_1)
PF14698
(ASL_C2) 		4 CYH A 121
LEU A 238
LEU A 190
ALA A 186
 None
 0.78A 5hpuA-1tj7A:
undetectable
5hpuB-1tj7A:
undetectable		 5hpuA-1tj7A:
4.70
5hpuB-1tj7A:
5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6g TIP120 PROTEIN

(Homo sapiens) 		PF08623
(TIP120) 		4 CYH C 527
LEU C 484
LEU C 498
ALA C 497
 None
 1.09A 5hpuA-1u6gC:
undetectable
5hpuB-1u6gC:
undetectable		 5hpuA-1u6gC:
3.59
5hpuB-1u6gC:
2.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wox HEME OXYGENASE 2

(Synechocystis
sp. PCC 6803) 		PF01126
(Heme_oxygenase) 		4 CYH A 123
LEU A  56
LEU A  52
ALA A  55
 None
 0.91A 5hpuA-1woxA:
undetectable
5hpuB-1woxA:
undetectable		 5hpuA-1woxA:
9.30
5hpuB-1woxA:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x4n FAR UPSTREAM ELEMENT
BINDING PROTEIN 1

(Mus musculus) 		PF00013
(KH_1) 		4 CYH A  62
LEU A  78
LEU A  64
ALA A  74
 None
 1.09A 5hpuA-1x4nA:
undetectable
5hpuB-1x4nA:
undetectable		 5hpuA-1x4nA:
14.29
5hpuB-1x4nA:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xnj BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1

(Homo sapiens) 		no annotation 4 CYH B 507
LEU B 552
LEU B 546
ALA B 549
 None
 0.60A 5hpuA-1xnjB:
undetectable
5hpuB-1xnjB:
undetectable		 5hpuA-1xnjB:
4.82
5hpuB-1xnjB:
4.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y1u SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 5A

(Mus musculus) 		PF00017
(SH2)
PF01017
(STAT_alpha)
PF02864
(STAT_bind) 		4 CYH A 279
LEU A 248
LEU A 327
ALA A 326
 None
 1.14A 5hpuA-1y1uA:
undetectable
5hpuB-1y1uA:
undetectable		 5hpuA-1y1uA:
3.48
5hpuB-1y1uA:
4.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli) 		PF04952
(AstE_AspA) 		4 CYH A 207
LEU A 209
LEU A 176
ALA A 179
 None
 1.05A 5hpuA-1yw6A:
undetectable
5hpuB-1yw6A:
undetectable		 5hpuA-1yw6A:
5.13
5hpuB-1yw6A:
6.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zel HYPOTHETICAL PROTEIN
RV2827C

(Mycobacterium
tuberculosis) 		PF09407
(AbiEi_1)
PF13338
(AbiEi_4) 		4 CYH A 211
LEU A 184
LEU A 235
ALA A 231
 None
 1.01A 5hpuA-1zelA:
undetectable
5hpuB-1zelA:
undetectable		 5hpuA-1zelA:
4.48
5hpuB-1zelA:
7.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2avd CATECHOL-O-METHYLTRA
NSFERASE

(Homo sapiens) 		PF01596
(Methyltransf_3) 		4 CYH A 198
LEU A 109
LEU A 167
ALA A 163
 None
None
None
SAM  A 501 (-3.5A)
 0.98A 5hpuA-2avdA:
undetectable
5hpuB-2avdA:
undetectable		 5hpuA-2avdA:
7.46
5hpuB-2avdA:
8.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfh TRAFFICKING PROTEIN
PARTICLE COMPLEX
SUBUNIT 6B

(Homo sapiens) 		PF04051
(TRAPP) 		4 CYH C 149
LEU C 102
LEU C 119
ALA C 115
 None
 1.01A 5hpuA-2cfhC:
undetectable
5hpuB-2cfhC:
undetectable		 5hpuA-2cfhC:
12.96
5hpuB-2cfhC:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d5u N-GLYCANASE 1

(Mus musculus) 		PF09409
(PUB) 		4 CYH A  79
LEU A  40
LEU A  25
ALA A  36
 None
 1.13A 5hpuA-2d5uA:
undetectable
5hpuB-2d5uA:
undetectable		 5hpuA-2d5uA:
10.26
5hpuB-2d5uA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hqy CONSERVED
HYPOTHETICAL PROTEIN

(Bacteroides
thetaiotaomicron) 		PF09924
(DUF2156) 		4 CYH A  35
LEU A   9
LEU A 204
ALA A 203
 None
 1.12A 5hpuA-2hqyA:
undetectable
5hpuB-2hqyA:
undetectable		 5hpuA-2hqyA:
16.09
5hpuB-2hqyA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0e PROTEIN KINASE
C-BETA II

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		4 CYH A 572
LEU A 535
LEU A 531
ALA A 443
 None
 1.08A 5hpuA-2i0eA:
undetectable
5hpuB-2i0eA:
undetectable		 5hpuA-2i0eA:
5.72
5hpuB-2i0eA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jsw TALIN-1

(Mus musculus) 		PF01608
(I_LWEQ) 		4 CYH A2442
LEU A2438
LEU A2393
ALA A2396
 None
 1.08A 5hpuA-2jswA:
undetectable
5hpuB-2jswA:
undetectable		 5hpuA-2jswA:
8.33
5hpuB-2jswA:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nwh CARBOHYDRATE KINASE

(Agrobacterium
fabrum) 		PF00294
(PfkB) 		4 CYH A 138
LEU A 161
LEU A 150
ALA A 154
 None
 1.09A 5hpuA-2nwhA:
undetectable
5hpuB-2nwhA:
undetectable		 5hpuA-2nwhA:
5.74
5hpuB-2nwhA:
7.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pvp D-ALANINE-D-ALANINE
LIGASE

(Helicobacter
pylori) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		4 CYH A 287
LEU A 275
LEU A 298
ALA A 137
 None
 1.10A 5hpuA-2pvpA:
undetectable
5hpuB-2pvpA:
undetectable		 5hpuA-2pvpA:
4.89
5hpuB-2pvpA:
6.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjf BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1

(Homo sapiens) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		4 CYH A 507
LEU A 552
LEU A 546
ALA A 549
 None
 0.64A 5hpuA-2qjfA:
undetectable
5hpuB-2qjfA:
undetectable		 5hpuA-2qjfA:
4.71
5hpuB-2qjfA:
6.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qrd SNF1-LIKE PROTEIN
KINASE SSP2
SPCC1919.03C PROTEIN

(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe) 		PF16579
(AdenylateSensor)
PF04739
(AMPKBI) 		4 CYH A 566
LEU B 265
LEU B 277
ALA B 267
 None
 0.99A 5hpuA-2qrdA:
undetectable
5hpuB-2qrdA:
undetectable		 5hpuA-2qrdA:
12.20
5hpuB-2qrdA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r1h HEMOGLOBIN SUBUNIT
ALPHA-4

(Oncorhynchus
mykiss) 		PF00042
(Globin) 		4 CYH A  70
LEU A  81
LEU A 133
ALA A 136
 None
 1.14A 5hpuA-2r1hA:
undetectable
5hpuB-2r1hA:
undetectable		 5hpuA-2r1hA:
10.94
5hpuB-2r1hA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9k UNCHARACTERIZED
PROTEIN FLJ32312

(Homo sapiens) 		no annotation 4 CYH A 112
LEU A 116
LEU A 182
ALA A 185
 ZN  A1533 (-2.3A)
ZN  A1533 ( 4.9A)
None
None
 1.02A 5hpuA-2v9kA:
undetectable
5hpuB-2v9kA:
undetectable		 5hpuA-2v9kA:
4.03
5hpuB-2v9kA:
5.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vws YFAU, 2-KETO-3-DEOXY
SUGAR ALDOLASE

(Escherichia
coli) 		PF03328
(HpcH_HpaI) 		4 CYH A 147
LEU A  13
LEU A 149
ALA A 212
 None
 1.05A 5hpuA-2vwsA:
undetectable
5hpuB-2vwsA:
undetectable		 5hpuA-2vwsA:
10.34
5hpuB-2vwsA:
7.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vx2 ENOYL-COA HYDRATASE
DOMAIN-CONTAINING
PROTEIN 3

(Homo sapiens) 		PF00378
(ECH_1) 		4 CYH A 155
LEU A 219
LEU A 190
ALA A 193
 None
 1.11A 5hpuA-2vx2A:
undetectable
5hpuB-2vx2A:
undetectable		 5hpuA-2vx2A:
6.27
5hpuB-2vx2A:
6.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wd5 STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
1A

(Mus musculus) 		PF06470
(SMC_hinge) 		4 CYH A 523
LEU A 519
LEU A 609
ALA A 608
 None
 1.03A 5hpuA-2wd5A:
undetectable
5hpuB-2wd5A:
undetectable		 5hpuA-2wd5A:
8.39
5hpuB-2wd5A:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wd5 STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
1A

(Mus musculus) 		PF06470
(SMC_hinge) 		4 CYH A 523
LEU A 538
LEU A 609
ALA A 612
 None
 1.08A 5hpuA-2wd5A:
undetectable
5hpuB-2wd5A:
undetectable		 5hpuA-2wd5A:
8.39
5hpuB-2wd5A:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtz UDP-N-ACETYLMURAMOYL
-L-ALANYL-D-GLUTAMAT
E--2,6-DIAMINOPIMELA
TE LIGASE

(Mycobacterium
tuberculosis) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 CYH A 348
LEU A 369
LEU A 352
ALA A 365
 None
 1.02A 5hpuA-2wtzA:
undetectable
5hpuB-2wtzA:
undetectable		 5hpuA-2wtzA:
3.16
5hpuB-2wtzA:
4.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsb HYALURONOGLUCOSAMINI
DASE

(Oceanicola
granulosus) 		PF07555
(NAGidase) 		4 CYH A 400
LEU A 333
LEU A 353
ALA A 352
 None
 1.06A 5hpuA-2xsbA:
undetectable
5hpuB-2xsbA:
undetectable		 5hpuA-2xsbA:
4.27
5hpuB-2xsbA:
5.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yjg LACTATE RACEMASE
APOPROTEIN

(Thermoanaerobacterium
thermosaccharolyticum) 		PF09861
(DUF2088) 		4 CYH A 195
LEU A 153
LEU A 187
ALA A 227
 None
 1.12A 5hpuA-2yjgA:
undetectable
5hpuB-2yjgA:
undetectable		 5hpuA-2yjgA:
4.43
5hpuB-2yjgA:
5.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zzr UNSATURATED
GLUCURONYL HYDROLASE

(Streptococcus
agalactiae) 		PF07470
(Glyco_hydro_88) 		4 CYH A  77
LEU A 358
LEU A  40
ALA A  36
 None
 0.98A 5hpuA-2zzrA:
undetectable
5hpuB-2zzrA:
undetectable		 5hpuA-2zzrA:
4.60
5hpuB-2zzrA:
6.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eh2 PROTEIN TRANSPORT
PROTEIN SEC24C

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		4 CYH A  49
LEU A 480
LEU A 502
ALA A 478
 None
 1.06A 5hpuA-3eh2A:
undetectable
5hpuB-3eh2A:
undetectable		 5hpuA-3eh2A:
2.73
5hpuB-3eh2A:
5.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqx FIC DOMAIN
CONTAINING
TRANSCRIPTIONAL
REGULATOR

(Shewanella
oneidensis) 		PF02661
(Fic)
PF13784
(Fic_N) 		4 CYH A 311
LEU A 316
LEU A 331
ALA A 327
 None
 1.11A 5hpuA-3eqxA:
undetectable
5hpuB-3eqxA:
undetectable		 5hpuA-3eqxA:
6.33
5hpuB-3eqxA:
4.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0r ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B

(Aquifex
aeolicus) 		PF02637
(GatB_Yqey)
PF02934
(GatB_N) 		4 CYH B 194
LEU B  11
LEU B 170
ALA B 166
 None
 1.10A 5hpuA-3h0rB:
undetectable
5hpuB-3h0rB:
undetectable		 5hpuA-3h0rB:
8.43
5hpuB-3h0rB:
5.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ilh TWO COMPONENT
RESPONSE REGULATOR

(Cytophaga
hutchinsonii) 		PF00072
(Response_reg) 		4 CYH A  63
LEU A 130
LEU A 122
ALA A 126
 None
 0.86A 5hpuA-3ilhA:
undetectable
5hpuB-3ilhA:
undetectable		 5hpuA-3ilhA:
10.45
5hpuB-3ilhA:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k3n PHD FINGER PROTEIN 8

(Homo sapiens) 		PF02373
(JmjC) 		4 CYH A 368
LEU A 344
LEU A 400
ALA A 399
 None
 1.02A 5hpuA-3k3nA:
undetectable
5hpuB-3k3nA:
undetectable		 5hpuA-3k3nA:
5.29
5hpuB-3k3nA:
5.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kv6 JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 1D

(Homo sapiens) 		PF00628
(PHD)
PF02373
(JmjC) 		4 CYH A 403
LEU A 379
LEU A 435
ALA A 434
 None
 1.10A 5hpuA-3kv6A:
undetectable
5hpuB-3kv6A:
undetectable		 5hpuA-3kv6A:
4.37
5hpuB-3kv6A:
4.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ljn HYPOTHETICAL PROTEIN

(Leishmania
major) 		PF00023
(Ank)
PF12796
(Ank_2) 		4 CYH A  57
LEU A  53
LEU A  99
ALA A  69
 None
 1.08A 5hpuA-3ljnA:
undetectable
5hpuB-3ljnA:
undetectable		 5hpuA-3ljnA:
5.38
5hpuB-3ljnA:
8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3md2 MATRIX PROTEIN 1

(Influenza A
virus) 		PF00598
(Flu_M1) 		4 CYH A 127
LEU A 103
LEU A 146
ALA A 142
 None
 1.13A 5hpuA-3md2A:
undetectable
5hpuB-3md2A:
undetectable		 5hpuA-3md2A:
13.10
5hpuB-3md2A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqb OXIDOREDUCTASE

(Bradyrhizobium
diazoefficiens) 		PF01408
(GFO_IDH_MocA) 		4 CYH A 112
LEU A 354
LEU A 100
ALA A 130
 None
 1.00A 5hpuA-3oqbA:
undetectable
5hpuB-3oqbA:
undetectable		 5hpuA-3oqbA:
4.32
5hpuB-3oqbA:
5.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3owc PROBABLE
ACETYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00583
(Acetyltransf_1) 		4 CYH A  81
LEU A  14
LEU A 116
ALA A 115
 None
 1.07A 5hpuA-3owcA:
undetectable
5hpuB-3owcA:
undetectable		 5hpuA-3owcA:
7.49
5hpuB-3owcA:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8c WISKOTT-ALDRICH
SYNDROME PROTEIN
FAMILY MEMBER 1
PROBABLE PROTEIN
BRICK1
ABL INTERACTOR 2

(Homo sapiens;
Homo sapiens;
Homo sapiens) 		PF02205
(WH2)
no annotation
PF07815
(Abi_HHR) 		4 CYH E  43
LEU F  76
LEU D  55
ALA D  59
 None
 1.08A 5hpuA-3p8cE:
undetectable
5hpuB-3p8cE:
undetectable		 5hpuA-3p8cE:
17.46
5hpuB-3p8cE:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfq PROTEIN KINASE C
BETA TYPE

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00130
(C1_1)
PF00168
(C2)
PF00433
(Pkinase_C) 		4 CYH A 572
LEU A 535
LEU A 531
ALA A 443
 None
 1.09A 5hpuA-3pfqA:
undetectable
5hpuB-3pfqA:
undetectable		 5hpuA-3pfqA:
2.88
5hpuB-3pfqA:
4.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3px2 N-METHYLTRANSFERASE

(Streptomyces
fradiae) 		PF13649
(Methyltransf_25) 		4 CYH A  59
LEU A  97
LEU A  65
ALA A  95
 None
 1.13A 5hpuA-3px2A:
undetectable
5hpuB-3px2A:
undetectable		 5hpuA-3px2A:
15.79
5hpuB-3px2A:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tbk RIG-I HELICASE
DOMAIN

(Mus musculus) 		PF00271
(Helicase_C)
PF04851
(ResIII) 		4 CYH A 375
LEU A 435
LEU A 431
ALA A 434
 None
 1.05A 5hpuA-3tbkA:
undetectable
5hpuB-3tbkA:
undetectable		 5hpuA-3tbkA:
4.29
5hpuB-3tbkA:
4.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txo PROTEIN KINASE C ETA
TYPE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		4 CYH A 549
LEU A 585
LEU A 577
ALA A 581
 None
 1.05A 5hpuA-3txoA:
undetectable
5hpuB-3txoA:
undetectable		 5hpuA-3txoA:
7.34
5hpuB-3txoA:
8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u78 LYSINE-SPECIFIC
DEMETHYLASE 7

(Homo sapiens) 		PF02373
(JmjC) 		4 CYH A 403
LEU A 379
LEU A 435
ALA A 434
 None
 0.97A 5hpuA-3u78A:
undetectable
5hpuB-3u78A:
undetectable		 5hpuA-3u78A:
5.35
5hpuB-3u78A:
5.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v77 PUTATIVE
FUMARYLACETOACETATE
ISOMERASE/HYDROLASE

(Oleispira
antarctica) 		PF01557
(FAA_hydrolase) 		4 CYH A 127
LEU A 189
LEU A 129
ALA A  73
 None
 1.12A 5hpuA-3v77A:
undetectable
5hpuB-3v77A:
undetectable		 5hpuA-3v77A:
7.04
5hpuB-3v77A:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wec CYTOCHROME P450

(Rhodococcus
erythropolis) 		PF00067
(p450) 		4 CYH A 247
LEU A 228
LEU A 224
ALA A 118
 None
 1.09A 5hpuA-3wecA:
undetectable
5hpuB-3wecA:
undetectable		 5hpuA-3wecA:
5.18
5hpuB-3wecA:
5.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wtf UNCHARACTERIZED
PROTEIN C9ORF142

(Homo sapiens) 		PF15384
(PAXX) 		4 CYH A  22
LEU A  87
LEU A  96
ALA A  94
 None
 1.11A 5hpuA-3wtfA:
undetectable
5hpuB-3wtfA:
undetectable		 5hpuA-3wtfA:
6.35
5hpuB-3wtfA:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d6v G PROTEIN BETA
SUBUNIT GIB2

(Cryptococcus
neoformans) 		PF00400
(WD40) 		4 CYH A 249
LEU A 298
LEU A 289
ALA A 300
 None
 0.88A 5hpuA-4d6vA:
undetectable
5hpuB-4d6vA:
undetectable		 5hpuA-4d6vA:
6.08
5hpuB-4d6vA:
8.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eag EG:132E8.2 PROTEIN
5'-AMP-ACTIVATED
PROTEIN KINASE
SUBUNIT BETA-1

(Drosophila
melanogaster;
Rattus
norvegicus) 		PF16579
(AdenylateSensor)
PF04739
(AMPKBI) 		4 CYH A 573
LEU B 239
LEU B 251
ALA B 241
 None
 1.09A 5hpuA-4eagA:
undetectable
5hpuB-4eagA:
undetectable		 5hpuA-4eagA:
9.84
5hpuB-4eagA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eal 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
5'-AMP-ACTIVATED
PROTEIN KINASE
SUBUNIT BETA-1

(Rattus
norvegicus;
Rattus
norvegicus) 		PF16579
(AdenylateSensor)
PF04739
(AMPKBI) 		4 CYH A 539
LEU B 239
LEU B 251
ALA B 241
 None
 1.07A 5hpuA-4ealA:
undetectable
5hpuB-4ealA:
undetectable		 5hpuA-4ealA:
13.13
5hpuB-4ealA:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fqd NIKO PROTEIN

(Streptomyces
tendae) 		PF00275
(EPSP_synthase) 		4 CYH A 273
LEU A 349
LEU A 417
ALA A 418
 None
 1.07A 5hpuA-4fqdA:
undetectable
5hpuB-4fqdA:
undetectable		 5hpuA-4fqdA:
3.82
5hpuB-4fqdA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3

(Legionella
pneumophila) 		no annotation 4 CYH A 602
LEU A 471
LEU A 571
ALA A 570
 None
 0.94A 5hpuA-4fyeA:
undetectable
5hpuB-4fyeA:
undetectable		 5hpuA-4fyeA:
2.79
5hpuB-4fyeA:
3.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i93 PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE
AT5G41260

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		4 CYH A 292
LEU A 288
LEU A 306
ALA A 309
 None
 0.97A 5hpuA-4i93A:
undetectable
5hpuB-4i93A:
undetectable		 5hpuA-4i93A:
5.68
5hpuB-4i93A:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j2h SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		4 CYH A 233
LEU A  30
LEU A   8
ALA A  35
 None
 1.13A 5hpuA-4j2hA:
undetectable
5hpuB-4j2hA:
undetectable		 5hpuA-4j2hA:
7.56
5hpuB-4j2hA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lij FAR UPSTREAM
ELEMENT-BINDING
PROTEIN 1

(Homo sapiens) 		PF00013
(KH_1) 		4 CYH A 147
LEU A 163
LEU A 149
ALA A 159
 None
 1.04A 5hpuA-4lijA:
undetectable
5hpuB-4lijA:
undetectable		 5hpuA-4lijA:
14.06
5hpuB-4lijA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nwb MRNA TURNOVER
PROTEIN 4

(Chaetomium
thermophilum) 		PF00466
(Ribosomal_L10) 		4 CYH A 195
LEU A 216
LEU A 201
ALA A 125
 None
 1.13A 5hpuA-4nwbA:
undetectable
5hpuB-4nwbA:
undetectable		 5hpuA-4nwbA:
14.66
5hpuB-4nwbA:
7.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfz 5-CARBOXYMETHYL-2-HY
DROXYMUCONATE
DELTA-ISOMERASE

(Mycolicibacterium
smegmatis) 		PF01557
(FAA_hydrolase)
PF10370
(DUF2437) 		4 CYH A 186
LEU A 244
LEU A 188
ALA A 136
 None
 1.13A 5hpuA-4pfzA:
undetectable
5hpuB-4pfzA:
undetectable		 5hpuA-4pfzA:
13.43
5hpuB-4pfzA:
6.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV

(Bacteroides
ovatus) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 CYH A  57
LEU A 466
LEU A 454
ALA A 464
 None
 0.96A 5hpuA-4q1vA:
undetectable
5hpuB-4q1vA:
undetectable		 5hpuA-4q1vA:
2.83
5hpuB-4q1vA:
4.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ra4 PROTEIN KINASE C

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		4 CYH A 569
LEU A 532
LEU A 528
ALA A 440
 None
 1.01A 5hpuA-4ra4A:
undetectable
5hpuB-4ra4A:
undetectable		 5hpuA-4ra4A:
5.71
5hpuB-4ra4A:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 CYH A 725
LEU A 721
LEU A 739
ALA A 742
 None
 1.06A 5hpuA-4xcuA:
undetectable
5hpuB-4xcuA:
undetectable		 5hpuA-4xcuA:
5.65
5hpuB-4xcuA:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xcw MOLYBDOPTERIN
ADENYLYLTRANSFERASE

(Helicobacter
pylori) 		PF00994
(MoCF_biosynth) 		4 CYH A 153
LEU A 128
LEU A  96
ALA A 121
 None
 1.13A 5hpuA-4xcwA:
undetectable
5hpuB-4xcwA:
undetectable		 5hpuA-4xcwA:
10.24
5hpuB-4xcwA:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgc ORIGIN RECOGNITION
COMPLEX SUBUNIT 4

(Drosophila
melanogaster) 		PF13191
(AAA_16)
PF14629
(ORC4_C) 		4 CYH D 219
LEU D 288
LEU D 279
ALA D 284
 None
 1.10A 5hpuA-4xgcD:
undetectable
5hpuB-4xgcD:
undetectable		 5hpuA-4xgcD:
5.59
5hpuB-4xgcD:
7.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE

(Neurospora
crassa) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		4 CYH A 568
LEU A 591
LEU A 587
ALA A 590
 None
 1.09A 5hpuA-4ztxA:
undetectable
5hpuB-4ztxA:
undetectable		 5hpuA-4ztxA:
2.24
5hpuB-4ztxA:
2.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d28 GM-CSF/IL-2
INHIBITION FACTOR

(Orf virus) 		no annotation 4 CYH A  90
LEU A 149
LEU A  40
ALA A 212
 None
 1.13A 5hpuA-5d28A:
undetectable
5hpuB-5d28A:
undetectable		 5hpuA-5d28A:
6.48
5hpuB-5d28A:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmq REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H P80

(Murine leukemia
virus) 		PF00075
(RNase_H)
PF00078
(RVT_1) 		4 CYH A 310
LEU A 280
LEU A 351
ALA A 354
 None
 1.14A 5hpuA-5dmqA:
undetectable
5hpuB-5dmqA:
undetectable		 5hpuA-5dmqA:
3.12
5hpuB-5dmqA:
3.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dzt CYLM

(Enterococcus
faecalis) 		PF05147
(LANC_like)
PF13575
(DUF4135) 		4 CYH A 654
LEU A 978
LEU A 708
ALA A 707
 None
 1.08A 5hpuA-5dztA:
undetectable
5hpuB-5dztA:
undetectable		 5hpuA-5dztA:
3.35
5hpuB-5dztA:
3.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e76 SUSD-LIKE PROTEIN
BACOVA_02651

(Bacteroides
ovatus) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 CYH A 146
LEU A 273
LEU A 142
ALA A 205
 None
 1.11A 5hpuA-5e76A:
undetectable
5hpuB-5e76A:
undetectable		 5hpuA-5e76A:
3.23
5hpuB-5e76A:
5.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epg ALDEHYDE OXIDASE

(Homo sapiens) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 CYH A 161
LEU A 144
LEU A 140
ALA A 143
 None
 1.11A 5hpuA-5epgA:
undetectable
5hpuB-5epgA:
undetectable		 5hpuA-5epgA:
2.77
5hpuB-5epgA:
1.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ic9 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF04003
(Utp12) 		4 CYH A 875
LEU A 910
LEU A 906
ALA A 909
 None
 1.13A 5hpuA-5ic9A:
undetectable
5hpuB-5ic9A:
undetectable		 5hpuA-5ic9A:
8.86
5hpuB-5ic9A:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ica PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF04003
(Utp12) 		4 CYH A 875
LEU A 910
LEU A 906
ALA A 909
 None
 1.08A 5hpuA-5icaA:
undetectable
5hpuB-5icaA:
undetectable		 5hpuA-5icaA:
11.02
5hpuB-5icaA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jk0 TYROSINE RECOMBINASE
XERH

(Helicobacter
pylori) 		PF00589
(Phage_integrase) 		4 CYH A  61
LEU A  57
LEU A  48
ALA A  51
 None
 1.09A 5hpuA-5jk0A:
undetectable
5hpuB-5jk0A:
undetectable		 5hpuA-5jk0A:
4.79
5hpuB-5jk0A:
6.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1b WD REPEAT-CONTAINING
PROTEIN 48

(Homo sapiens) 		PF00400
(WD40)
PF11816
(DUF3337) 		4 CYH B 200
LEU B 143
LEU B 164
ALA B 133
 None
 1.09A 5hpuA-5k1bB:
undetectable
5hpuB-5k1bB:
undetectable		 5hpuA-5k1bB:
3.54
5hpuB-5k1bB:
4.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ko9 EMBRYONIC STEM
CELL-SPECIFIC
5-HYDROXYMETHYLCYTOS
INE-BINDING PROTEIN

(Homo sapiens) 		PF02586
(SRAP) 		4 CYH A   7
LEU A 173
LEU A  14
ALA A  17
 None
 0.97A 5hpuA-5ko9A:
undetectable
5hpuB-5ko9A:
undetectable		 5hpuA-5ko9A:
7.92
5hpuB-5ko9A:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF12859
(ANAPC1) 		4 CYH A1887
LEU A1800
LEU A1811
ALA A1796
 None
 1.07A 5hpuA-5lcwA:
undetectable
5hpuB-5lcwA:
undetectable		 5hpuA-5lcwA:
1.63
5hpuB-5lcwA:
1.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5log PUTATIVE
O-METHYLTRANSFERASE

(Myxococcus
xanthus) 		PF01596
(Methyltransf_3) 		4 CYH A  90
LEU A 124
LEU A  64
ALA A 155
 None
 1.04A 5hpuA-5logA:
undetectable
5hpuB-5logA:
undetectable		 5hpuA-5logA:
8.28
5hpuB-5logA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mu5 UNCHARACTERIZED
PROTEIN

(Magnetospirillum
magneticum) 		no annotation 4 CYH A 557
LEU A 575
LEU A 598
ALA A 602
 None
 1.14A 5hpuA-5mu5A:
undetectable
5hpuB-5mu5A:
undetectable		 5hpuA-5mu5A:
2.90
5hpuB-5mu5A:
4.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Homo sapiens) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 CYH A2454
LEU A2502
LEU A2437
ALA A2436
 None
 1.00A 5hpuA-5nugA:
undetectable
5hpuB-5nugA:
undetectable		 5hpuA-5nugA:
0.56
5hpuB-5nugA:
0.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t8y EPOXYQUEUOSINE
REDUCTASE

(Bacillus
subtilis) 		PF08331
(DUF1730)
PF13484
(Fer4_16)
PF13646
(HEAT_2) 		4 CYH A 156
LEU A 209
LEU A 203
ALA A 202
 B12  A 503 ( 4.5A)
B12  A 503 ( 3.9A)
SF4  A 502 ( 4.6A)
SF4  A 502 ( 3.9A)
 1.03A 5hpuA-5t8yA:
undetectable
5hpuB-5t8yA:
undetectable		 5hpuA-5t8yA:
3.62
5hpuB-5t8yA:
4.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		4 CYH A1065
LEU A1150
LEU A1040
ALA A1054
 None
 0.98A 5hpuA-5tuyA:
undetectable
5hpuB-5tuyA:
undetectable		 5hpuA-5tuyA:
9.68
5hpuB-5tuyA:
8.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u5g 6-PHOSPHOGLUCONATE
DEHYDROGENASE

(Pseudomonas
syringae) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		4 CYH A  18
LEU A  10
LEU A  41
ALA A  38
 None
 1.13A 5hpuA-5u5gA:
undetectable
5hpuB-5u5gA:
undetectable		 5hpuA-5u5gA:
9.09
5hpuB-5u5gA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ux2 ALDEHYDE
DECARBONYLASE

(Synechococcus
sp. RS9917) 		no annotation 4 CYH A 110
LEU A 106
LEU A 142
ALA A 145
 None
 1.02A 5hpuA-5ux2A:
undetectable
5hpuB-5ux2A:
undetectable		 5hpuA-5ux2A:
undetectable
5hpuB-5ux2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vkq NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L

(Drosophila
melanogaster) 		PF00023
(Ank)
PF00520
(Ion_trans)
PF12796
(Ank_2)
PF13637
(Ank_4) 		4 CYH A1097
LEU A1129
LEU A1081
ALA A1085
 None
 0.98A 5hpuA-5vkqA:
undetectable
5hpuB-5vkqA:
undetectable		 5hpuA-5vkqA:
3.06
5hpuB-5vkqA:
1.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vm1 XYLULOKINASE

(Brucella ovis) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 CYH A 446
LEU A 432
LEU A 283
ALA A 282
 None
 1.13A 5hpuA-5vm1A:
undetectable
5hpuB-5vm1A:
undetectable		 5hpuA-5vm1A:
4.72
5hpuB-5vm1A:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vve PHOSPHOGLYCERATE
MUTASE

(Naegleria
fowleri) 		PF00300
(His_Phos_1) 		4 CYH A  54
LEU A  70
LEU A  66
ALA A  69
 None
 1.13A 5hpuA-5vveA:
undetectable
5hpuB-5vveA:
undetectable		 5hpuA-5vveA:
6.09
5hpuB-5vveA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xd6 PROTEIN KINASE
SUPERFAMILY PROTEIN

(Arabidopsis
thaliana) 		no annotation 4 CYH A 303
LEU A 295
LEU A 270
ALA A 324
 None
 0.92A 5hpuA-5xd6A:
undetectable
5hpuB-5xd6A:
undetectable		 5hpuA-5xd6A:
undetectable
5hpuB-5xd6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xn6 OS02G0668100 PROTEIN

(Oryza sativa) 		PF00348
(polyprenyl_synt) 		4 CYH C 193
LEU C 151
LEU C  77
ALA C  76
 None
 0.98A 5hpuA-5xn6C:
undetectable
5hpuB-5xn6C:
undetectable		 5hpuA-5xn6C:
6.61
5hpuB-5xn6C:
6.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xn6 OS02G0668100 PROTEIN

(Oryza sativa) 		PF00348
(polyprenyl_synt) 		4 CYH C 197
LEU C 151
LEU C  77
ALA C  76
 None
 1.13A 5hpuA-5xn6C:
undetectable
5hpuB-5xn6C:
undetectable		 5hpuA-5xn6C:
6.61
5hpuB-5xn6C:
6.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a91 -

(-) 		no annotation 4 CYH A 406
LEU A1299
LEU A1292
ALA A1295
 None
 0.90A 5hpuA-6a91A:
undetectable
5hpuB-6a91A:
undetectable		 5hpuA-6a91A:
undetectable
5hpuB-6a91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c54 NUCLEOPROTEIN

(Zaire
ebolavirus) 		no annotation 4 CYH A  78
LEU A 214
LEU A 151
ALA A 154
 None
 0.98A 5hpuA-6c54A:
undetectable
5hpuB-6c54A:
undetectable		 5hpuA-6c54A:
undetectable
5hpuB-6c54A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5o POLYMERASE ACIDIC
PROTEIN

(Influenza B
virus) 		no annotation 4 CYH A 343
LEU A 339
LEU A 356
ALA A 362
 None
 1.14A 5hpuA-6f5oA:
undetectable
5hpuB-6f5oA:
undetectable		 5hpuA-6f5oA:
undetectable
5hpuB-6f5oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fdy -

(-) 		no annotation 4 CYH U 243
LEU U 207
LEU U 203
ALA U 206
 None
 1.00A 5hpuA-6fdyU:
undetectable
5hpuB-6fdyU:
undetectable		 5hpuA-6fdyU:
undetectable
5hpuB-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ftl RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN

(Skeletonema
marinoi) 		no annotation 4 CYH A 387
LEU A 460
LEU A 450
ALA A 453
 None
 0.75A 5hpuA-6ftlA:
undetectable
5hpuB-6ftlA:
undetectable		 5hpuA-6ftlA:
undetectable
5hpuB-6ftlA:
undetectable