SIMILAR PATTERNS OF AMINO ACIDS FOR 5HP1_C_PPFC601_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f1m OUTER SURFACE
PROTEIN C

(Borreliella
burgdorferi) 		PF01441
(Lipoprotein_6) 		4 ASP A 152
GLY A  77
ASP A  91
LYS A 156
 None
 1.41A 5hp1C-1f1mA:
0.0		 5hp1C-1f1mA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ka0 HALOTOLERANCE
PROTEIN HAL2

(Saccharomyces
cerevisiae) 		PF00459
(Inositol_P) 		4 ARG A 281
ASP A 145
GLY A 146
ASP A 142
 AMP  A 401 (-3.1A)
None
AMP  A 401 ( 4.1A)
NA  A 501 (-2.8A)
 1.35A 5hp1C-1ka0A:
0.0		 5hp1C-1ka0A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pl0 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Homo sapiens) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		4 ARG A 307
GLY A 340
ASP A 339
LYS A 357
 None
 1.18A 5hp1C-1pl0A:
0.0		 5hp1C-1pl0A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txo PUTATIVE BACTERIAL
ENZYME

(Mycobacterium
tuberculosis) 		PF13672
(PP2C_2) 		4 ARG A  20
ASP A  38
GLY A  39
ASP A  25
 None
MN  A 700 ( 2.6A)
MN  A 701 (-4.2A)
MN  A 700 ( 4.8A)
 1.22A 5hp1C-1txoA:
0.0		 5hp1C-1txoA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6r CREATINE KINASE, M
CHAIN

(Oryctolagus
cuniculus) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		4 ASP A 118
GLY A 116
ASP A 119
LYS A 246
 None
 1.31A 5hp1C-1u6rA:
4.3		 5hp1C-1u6rA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uok OLIGO-1,6-GLUCOSIDAS
E

(Bacillus cereus) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 LYS A 395
ARG A 399
ASP A 295
GLY A 292
 None
 1.21A 5hp1C-1uokA:
0.0		 5hp1C-1uokA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vdc NADPH DEPENDENT
THIOREDOXIN
REDUCTASE

(Arabidopsis
thaliana) 		PF07992
(Pyr_redox_2) 		4 ARG A 293
ASP A 259
GLY A 261
ASP A 261
 None
 1.43A 5hp1C-1vdcA:
0.0		 5hp1C-1vdcA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y8q UBIQUITIN-LIKE 2
ACTIVATING ENZYME
E1B

(Homo sapiens) 		PF00899
(ThiF)
PF14732
(UAE_UbL)
PF16195
(UBA2_C) 		4 ARG B  59
ASP B 347
ASP B  53
LYS B 346
 ATP  B 802 (-4.1A)
ATP  B 802 ( 4.3A)
None
ATP  B 802 (-2.9A)
 1.22A 5hp1C-1y8qB:
0.8		 5hp1C-1y8qB:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yjg SURFACE PROTEIN VSPA

(Borrelia
turicatae) 		PF01441
(Lipoprotein_6) 		4 ASP A 154
GLY A  76
ASP A  89
LYS A 158
 None
 1.43A 5hp1C-1yjgA:
2.6		 5hp1C-1yjgA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D

(Pyrococcus
abyssi) 		PF00710
(Asparaginase) 		4 ARG A 370
ASP A 270
GLY A 425
LYS A 253
 None
 1.39A 5hp1C-1zq1A:
undetectable		 5hp1C-1zq1A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ctz O-ACETYL-L-HOMOSERIN
E SULFHYDRYLASE

(Thermus
thermophilus) 		PF01053
(Cys_Met_Meta_PP) 		4 ASP A 263
GLY A 264
ASP A 267
LYS A 259
 None
 1.42A 5hp1C-2ctzA:
2.1		 5hp1C-2ctzA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f7l 455AA LONG
HYPOTHETICAL
PHOSPHO-SUGAR MUTASE

(Sulfurisphaera
tokodaii) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 ARG A  11
ASP A 243
GLY A 242
ASP A 245
 None
 1.13A 5hp1C-2f7lA:
3.9		 5hp1C-2f7lA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2faq PROBABLE
ATP-DEPENDENT DNA
LIGASE

(Pseudomonas
aeruginosa) 		no annotation 4 ARG A 776
ASP A 671
GLY A 708
ASP A 669
 ATP  A1304 (-3.0A)
MN  A 501 (-2.5A)
ATP  A1304 (-3.8A)
MN  A 501 (-2.2A)
 1.25A 5hp1C-2faqA:
3.7		 5hp1C-2faqA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2faq PROBABLE
ATP-DEPENDENT DNA
LIGASE

(Pseudomonas
aeruginosa) 		no annotation 4 ARG A 778
ASP A 671
GLY A 708
ASP A 669
 ATP  A1304 (-2.6A)
MN  A 501 (-2.5A)
ATP  A1304 (-3.8A)
MN  A 501 (-2.2A)
 1.18A 5hp1C-2faqA:
3.7		 5hp1C-2faqA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fym ENOLASE

(Escherichia
coli) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 ARG A  45
ASP A 290
GLY A 315
ASP A 316
 None
None
None
MG  A1431 (-3.3A)
 0.91A 5hp1C-2fymA:
undetectable		 5hp1C-2fymA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ga0 SURFACE PROTEIN VSPA

(Borrelia
turicatae) 		PF01441
(Lipoprotein_6) 		4 ASP A 154
GLY A  76
ASP A  89
LYS A 158
 None
 1.41A 5hp1C-2ga0A:
undetectable		 5hp1C-2ga0A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7n RNA-DEPENDENT RNA
POLYMERASE

(Neurospora
crassa) 		PF05183
(RdRP) 		4 LYS A1119
ASP A1007
GLY A 710
ASP A 709
 None
MG  A3374 (-2.6A)
None
None
 1.44A 5hp1C-2j7nA:
undetectable		 5hp1C-2j7nA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7n RNA-DEPENDENT RNA
POLYMERASE

(Neurospora
crassa) 		PF05183
(RdRP) 		4 LYS A1119
ASP A1009
GLY A 710
ASP A1007
 None
MG  A3374 (-2.4A)
None
MG  A3374 (-2.6A)
 1.41A 5hp1C-2j7nA:
undetectable		 5hp1C-2j7nA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zkt 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Pyrococcus
horikoshii) 		PF01676
(Metalloenzyme)
PF10143
(PhosphMutase) 		4 ASP A  13
GLY A  14
ASP A 346
LYS A 302
 ZN  A 414 (-2.2A)
None
ZN  A 414 (-2.8A)
ZN  A 415 ( 4.5A)
 1.18A 5hp1C-2zktA:
undetectable		 5hp1C-2zktA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zux YESW PROTEIN

(Bacillus
subtilis) 		no annotation 4 ARG A  40
ASP A 371
GLY A 372
ASP A 373
 None
CA  A 638 ( 2.7A)
None
CA  A 638 ( 2.6A)
 1.33A 5hp1C-2zuxA:
undetectable		 5hp1C-2zuxA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Schizosaccharomyces
pombe) 		PF00562
(RNA_pol_Rpb2_6)
PF00623
(RNA_pol_Rpb1_2)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 ARG B 755
ASP A 489
GLY B 977
ASP B 826
 None
 1.23A 5hp1C-3h0gB:
undetectable		 5hp1C-3h0gB:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT

(Eubacterium
barkeri) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 ARG A 266
GLY A 241
ASP A 244
LYS A 277
 None
 1.26A 5hp1C-3hrdA:
undetectable		 5hp1C-3hrdA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT

(Saccharomyces
cerevisiae) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 LYS A 701
ARG A 674
ASP A 764
ASP A 608
 DCP  A 986 (-2.7A)
DCP  A 986 (-2.9A)
CA  A   2 (-2.8A)
CA  A   3 ( 2.3A)
 1.44A 5hp1C-3iayA:
4.8		 5hp1C-3iayA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icf SERINE/THREONINE-PRO
TEIN PHOSPHATASE T

(Saccharomyces
cerevisiae) 		PF00149
(Metallophos)
PF08321
(PPP5) 		4 ARG A 432
ASP A 278
GLY A 277
ASP A 249
 None
FE  A 601 (-2.5A)
None
FE  A 602 (-3.1A)
 1.44A 5hp1C-3icfA:
undetectable		 5hp1C-3icfA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jur EXO-POLY-ALPHA-D-GAL
ACTURONOSIDASE

(Thermotoga
maritima) 		PF00295
(Glyco_hydro_28)
PF12708
(Pectate_lyase_3) 		4 ARG A 189
ASP A 260
GLY A 259
ASP A 239
 None
 1.27A 5hp1C-3jurA:
undetectable		 5hp1C-3jurA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kd6 CARBOHYDRATE KINASE,
PFKB FAMILY

(Chlorobaculum
tepidum) 		PF00294
(PfkB) 		4 ARG A  94
ASP A 147
GLY A 236
ASP A 237
 AMP  A 509 (-2.7A)
GOL  A 501 (-3.2A)
GOL  A 501 ( 3.2A)
AMP  A 509 ( 3.3A)
 1.39A 5hp1C-3kd6A:
undetectable		 5hp1C-3kd6A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nm1 THIAMINE
BIOSYNTHETIC
BIFUNCTIONAL ENZYME

([Candida]
glabrata) 		PF02110
(HK)
PF02581
(TMP-TENI) 		4 LYS A 146
ASP A  95
GLY A  92
ASP A  76
 POP  A 543 (-2.9A)
MG  A 544 ( 2.6A)
POP  A 543 (-2.9A)
MG  A 544 ( 3.2A)
 1.31A 5hp1C-3nm1A:
undetectable		 5hp1C-3nm1A:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvs 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Vibrio cholerae) 		PF00275
(EPSP_synthase) 		4 ARG A 345
ASP A  49
GLY A  96
LYS A  22
 GPJ  A 429 (-2.6A)
GPJ  A 429 ( 4.7A)
GPJ  A 429 (-3.2A)
S3P  A 427 (-2.6A)
 1.09A 5hp1C-3nvsA:
undetectable		 5hp1C-3nvsA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sun DNA POLYMERASE

(Escherichia
virus RB69) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 LYS A 560
ARG A 482
ASP A 623
ASP A 411
 TTP  A 896 (-2.8A)
TTP  A 896 (-2.9A)
CA  A 897 (-2.9A)
CA  A 897 (-2.4A)
 1.30A 5hp1C-3sunA:
3.0		 5hp1C-3sunA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ugs UNDECAPRENYL
PYROPHOSPHATE
SYNTHASE

(Campylobacter
jejuni) 		no annotation 4 ARG B 144
ASP B  99
GLY B  98
ASP B 136
 None
 1.29A 5hp1C-3ugsB:
undetectable		 5hp1C-3ugsB:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a01 PROTON
PYROPHOSPHATASE

(Vigna radiata) 		PF03030
(H_PPase) 		4 ASP A 727
GLY A 726
ASP A 723
LYS A 250
 MG  A1769 ( 2.5A)
None
MG  A1769 ( 3.9A)
2PN  A1773 (-3.1A)
 1.44A 5hp1C-4a01A:
0.9		 5hp1C-4a01A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ee1 DNA PRIMASE

(Staphylococcus
aureus) 		PF08275
(Toprim_N)
PF13155
(Toprim_2) 		4 ARG A 146
ASP A 270
GLY A 267
ASP A 343
 CTP  A 501 (-2.9A)
CTP  A 501 ( 3.9A)
CTP  A 501 (-3.0A)
MN  A 504 (-2.7A)
 1.19A 5hp1C-4ee1A:
undetectable		 5hp1C-4ee1A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9i HYDROGENASE
MATURATION PROTEIN
HYPF

(Thermococcus
kodakarensis) 		PF00708
(Acylphosphatase)
PF00814
(Peptidase_M22)
PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF) 		4 ARG A 628
ASP A 509
GLY A 714
ASP A 746
 None
ZN  A1003 (-2.2A)
ZN  A1003 ( 4.6A)
ZN  A1003 (-2.4A)
 1.11A 5hp1C-4g9iA:
2.3		 5hp1C-4g9iA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mgg MUCONATE LACTONIZING
ENZYME

(Labrenzia
aggregata) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ARG A 205
ASP A 172
GLY A 168
ASP A 169
 None
 1.50A 5hp1C-4mggA:
undetectable		 5hp1C-4mggA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nen INTEGRIN ALPHA-X

(Homo sapiens) 		PF00092
(VWA)
PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		4 ARG A 480
GLY A 542
ASP A 449
LYS A 868
 None
None
CA  A1115 (-2.9A)
None
 1.21A 5hp1C-4nenA:
undetectable		 5hp1C-4nenA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6m AF2299, A
CDP-ALCOHOL
PHOSPHOTRANSFERASE

(Archaeoglobus
fulgidus) 		PF01066
(CDP-OH_P_transf) 		4 LYS A 148
ASP A 214
GLY A 215
ASP A 235
 SO4  A 411 (-4.9A)
CA  A 401 (-2.7A)
CA  A 401 ( 4.7A)
CA  A 401 (-2.2A)
 1.35A 5hp1C-4o6mA:
undetectable		 5hp1C-4o6mA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pc4 30K LIPOPROTEIN

(Bombyx mori) 		PF03260
(Lipoprotein_11) 		4 ASP A 122
GLY A 121
ASP A 221
LYS A 126
 None
 1.34A 5hp1C-4pc4A:
undetectable		 5hp1C-4pc4A:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qww ACETYLCHOLINESTERASE

(Bungarus
fasciatus) 		PF00135
(COesterase) 		4 ARG A 517
ASP A 392
GLY A 328
ASP A 326
 None
 1.06A 5hp1C-4qwwA:
undetectable		 5hp1C-4qwwA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3p 4-ALPHA-GLUCANOTRANS
FERASE

(Escherichia
coli) 		PF02446
(Glyco_hydro_77) 		4 ARG A 245
ASP A 163
GLY A 162
ASP A 166
 None
 1.26A 5hp1C-4s3pA:
undetectable		 5hp1C-4s3pA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uwa RYANODINE RECEPTOR 1

(Oryctolagus
cuniculus) 		PF00622
(SPRY)
PF01365
(RYDR_ITPR)
PF02026
(RyR)
PF02815
(MIR)
PF08709
(Ins145_P3_rec) 		4 ARG A 652
ASP A 709
GLY A 708
ASP A 710
 None
 1.41A 5hp1C-4uwaA:
undetectable		 5hp1C-4uwaA:
8.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x0q DNA POLYMERASE THETA

(Homo sapiens) 		PF00476
(DNA_pol_A) 		4 ARG A2379
ASP A2330
ASP A2540
LYS A2575
 DG3  A2604 (-3.4A)
MG  A2603 ( 2.3A)
MG  A2603 ( 2.6A)
DG3  A2604 ( 3.7A)
 1.06A 5hp1C-4x0qA:
4.5		 5hp1C-4x0qA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c5v ACIDOCALCISOMAL
PYROPHOSPHATASE

(Trypanosoma
brucei) 		PF00719
(Pyrophosphatase) 		4 LYS A 237
ARG A 259
ASP A 296
ASP A 328
 2PN  A 501 (-2.7A)
2PN  A 501 ( 2.9A)
MG  A 505 (-2.3A)
MG  A 503 (-2.3A)
 1.35A 5hp1C-5c5vA:
undetectable		 5hp1C-5c5vA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsw RNA DEPENDENT RNA
POLYMERASE QDE-1

(Thielavia
terrestris) 		PF05183
(RdRP) 		4 LYS A 741
ASP A 628
GLY A 627
ASP A 632
 None
 1.42A 5hp1C-5fswA:
2.2		 5hp1C-5fswA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m04 GTPASE OBGE/CGTA

(Escherichia
coli) 		PF01018
(GTP1_OBG)
PF01926
(MMR_HSR1) 		4 ASP A  44
GLY A  43
ASP A  85
LYS A 119
 None
 1.22A 5hp1C-5m04A:
undetectable		 5hp1C-5m04A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ti1 FUMARYLACETOACETATE
HYDROLASE

(Paraburkholderia
xenovorans) 		PF01557
(FAA_hydrolase)
PF09298
(FAA_hydrolase_N) 		4 ARG A 256
ASP A 145
GLY A 368
ASP A 252
 None
MG  A 501 (-2.9A)
MG  A 501 ( 4.7A)
NA  A 502 ( 3.3A)
 1.23A 5hp1C-5ti1A:
undetectable		 5hp1C-5ti1A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vjw RHIZOBIALES-LIKE
PHOSPHATASE 2

(Arabidopsis
thaliana) 		no annotation 4 ARG A 245
ASP A  13
GLY A 283
ASP A  47
 WO4  A 403 (-2.5A)
ZN  A 402 (-3.1A)
None
ZN  A 401 (-2.7A)
 1.28A 5hp1C-5vjwA:
undetectable		 5hp1C-5vjwA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ar3 GSI-IIC RT

(Geobacillus
stearothermophilus) 		no annotation 5 LYS A  69
ARG A  75
ASP A 138
ASP A 223
LYS A 258
 DTP  A 501 (-2.9A)
DTP  A 501 (-4.0A)
MG  A 502 ( 2.8A)
MG  A 502 ( 2.9A)
DTP  A 501 (-2.8A)
 1.24A 5hp1C-6ar3A:
7.6		 5hp1C-6ar3A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b67 PROTEIN PHOSPHATASE
1A

(Homo sapiens) 		no annotation 4 ARG A  33
ASP A  60
GLY A  61
ASP A  38
 None
CA  A 302 ( 2.8A)
CA  A 301 (-4.2A)
None
 1.33A 5hp1C-6b67A:
undetectable		 5hp1C-6b67A:
8.81