SIMILAR PATTERNS OF AMINO ACIDS FOR 5HP1_A_PPFA602

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b74 GLUTAMATE RACEMASE

(Aquifex
pyrophilus) 		PF01177
(Asp_Glu_race) 		4 ARG A  20
GLY A 216
ASP A  27
ASP A 214
 None
 1.30A 5hp1A-1b74A:
undetectable		 5hp1A-1b74A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bci CYTOSOLIC
PHOSPHOLIPASE A2

(Homo sapiens) 		PF00168
(C2) 		4 ASP A  93
GLY A  36
ASP A  37
ASP A  43
 CA  A 140 (-3.6A)
None
None
CA  A 139 ( 2.9A)
 1.19A 5hp1A-1bciA:
undetectable		 5hp1A-1bciA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3e TYROSYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00579
(tRNA-synt_1b) 		4 ARG A 155
GLY A  88
ASP A 157
ASP A  85
 None
None
None
TYE  A1434 (-3.8A)
 1.32A 5hp1A-1h3eA:
0.4		 5hp1A-1h3eA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ihb CYCLIN-DEPENDENT
KINASE 6 INHIBITOR

(Homo sapiens) 		PF13637
(Ank_4)
PF13857
(Ank_5) 		4 ARG A  79
ASP A  67
GLY A  70
ASP A 100
 None
 1.12A 5hp1A-1ihbA:
undetectable		 5hp1A-1ihbA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kzh PHOSPHOFRUCTOKINASE

(Borreliella
burgdorferi) 		PF00365
(PFK) 		4 ARG A 146
ASP A 208
GLY A 175
ASP A 176
 SO4  A 600 ( 3.6A)
None
SO4  A 601 (-3.1A)
SO4  A 601 (-3.8A)
 1.31A 5hp1A-1kzhA:
undetectable		 5hp1A-1kzhA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrk UDP-GLUCOSE
4-EPIMERASE

(Escherichia
coli) 		PF16363
(GDP_Man_Dehyd) 		4 ARG A 231
ASP A 130
GLY A 294
ASP A 295
 UD1  A 341 (-4.0A)
None
None
UD1  A 341 (-3.5A)
 1.13A 5hp1A-1lrkA:
undetectable		 5hp1A-1lrkA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m53 ISOMALTULOSE
SYNTHASE

(Klebsiella sp.
LX3) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 ARG A 165
GLY A 198
ASP A 194
ASP A 172
 None
 0.96A 5hp1A-1m53A:
undetectable		 5hp1A-1m53A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q0u BSTDEAD

(Geobacillus
stearothermophilus) 		PF00270
(DEAD) 		4 ARG A 142
ASP A 170
GLY A 135
ASP A 139
 None
 1.29A 5hp1A-1q0uA:
undetectable		 5hp1A-1q0uA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q15 CARA

(Pectobacterium
carotovorum) 		PF00733
(Asn_synthase)
PF09147
(DUF1933) 		4 ARG A 394
ASP A  81
GLY A  57
ASP A 103
 None
 1.30A 5hp1A-1q15A:
undetectable		 5hp1A-1q15A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txo PUTATIVE BACTERIAL
ENZYME

(Mycobacterium
tuberculosis) 		PF13672
(PP2C_2) 		4 ARG A  20
ASP A  38
GLY A  39
ASP A  25
 None
MN  A 700 ( 2.6A)
MN  A 701 (-4.2A)
MN  A 700 ( 4.8A)
 1.30A 5hp1A-1txoA:
undetectable		 5hp1A-1txoA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txo PUTATIVE BACTERIAL
ENZYME

(Mycobacterium
tuberculosis) 		PF13672
(PP2C_2) 		4 ARG A  20
ASP A 191
GLY A 192
ASP A 195
 None
MN  A 700 ( 2.6A)
MN  A 700 ( 4.9A)
MN  A 702 ( 4.1A)
 1.17A 5hp1A-1txoA:
undetectable		 5hp1A-1txoA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2v ACTIN-RELATED
PROTEIN 3
ARP2/3 COMPLEX 34KDA
SUBUNIT

(Bos taurus) 		PF00022
(Actin)
PF04045
(P34-Arc) 		4 ARG D 248
ASP A 107
GLY D  40
ASP D  39
 None
 1.21A 5hp1A-1u2vD:
3.7		 5hp1A-1u2vD:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w0h 3'-5' EXONUCLEASE
ERI1

(Homo sapiens) 		PF00929
(RNase_T) 		4 ARG A 272
ASP A 234
GLY A 231
ASP A 230
 None
MG  A1000 ( 3.1A)
None
None
 1.12A 5hp1A-1w0hA:
undetectable		 5hp1A-1w0hA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ws0 PEPTIDE DEFORMYLASE
1

(Bacillus cereus) 		PF01327
(Pep_deformylase) 		4 ASP A  66
GLY A  68
ASP A  62
ASP A  64
 None
 1.27A 5hp1A-1ws0A:
undetectable		 5hp1A-1ws0A:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bod ENDOGLUCANASE E-2

(Thermobifida
fusca) 		PF01341
(Glyco_hydro_6) 		4 LYS X 259
ARG X 221
GLY X 266
ASP X 233
 BGC  X1289 ( 2.7A)
BGC  X1289 ( 4.7A)
None
None
 1.20A 5hp1A-2bodX:
undetectable		 5hp1A-2bodX:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4b BARNASE MCOEETI
FUSION

(Bacillus
amyloliquefaciens;
Ecballium
elaterium;
Momordica
cochinchinensis) 		PF00299
(Squash)
PF00545
(Ribonuclease) 		4 ARG A  83
GLY A  52
ASP A  75
ASP A  54
 SO4  A1161 ( 3.2A)
None
None
None
 1.31A 5hp1A-2c4bA:
undetectable		 5hp1A-2c4bA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dfj DIADENOSINETETRAPHOS
PHATASE

(Shigella
flexneri) 		PF00149
(Metallophos) 		4 ARG A  41
ASP A 244
GLY A 246
ASP A   8
 None
MN  A1002 ( 4.5A)
None
MN  A1002 (-3.2A)
 1.08A 5hp1A-2dfjA:
undetectable		 5hp1A-2dfjA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e5v L-ASPARTATE OXIDASE

(Sulfurisphaera
tokodaii) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 ASP A 340
GLY A 342
ASP A  70
ASP A 205
 None
 1.10A 5hp1A-2e5vA:
undetectable		 5hp1A-2e5vA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2faq PROBABLE
ATP-DEPENDENT DNA
LIGASE

(Pseudomonas
aeruginosa) 		no annotation 4 ARG A 776
ASP A 671
GLY A 708
ASP A 669
 ATP  A1304 (-3.0A)
MN  A 501 (-2.5A)
ATP  A1304 (-3.8A)
MN  A 501 (-2.2A)
 0.85A 5hp1A-2faqA:
3.8		 5hp1A-2faqA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2faq PROBABLE
ATP-DEPENDENT DNA
LIGASE

(Pseudomonas
aeruginosa) 		no annotation 4 ARG A 778
ASP A 671
GLY A 708
ASP A 669
 ATP  A1304 (-2.6A)
MN  A 501 (-2.5A)
ATP  A1304 (-3.8A)
MN  A 501 (-2.2A)
 0.89A 5hp1A-2faqA:
3.8		 5hp1A-2faqA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fym ENOLASE

(Escherichia
coli) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 ARG A  45
ASP A 290
GLY A 315
ASP A 316
 None
None
None
MG  A1431 (-3.3A)
 1.30A 5hp1A-2fymA:
undetectable		 5hp1A-2fymA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ics ADENINE DEAMINASE

(Enterococcus
faecalis) 		PF01979
(Amidohydro_1) 		4 ASP A 243
GLY A 245
ASP A 272
ASP A  59
 None
None
ZN  A 400 (-2.8A)
None
 1.18A 5hp1A-2icsA:
undetectable		 5hp1A-2icsA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jft SER-THR PHOSPHATASE
MSPP

(Mycolicibacterium
smegmatis) 		PF13672
(PP2C_2) 		4 ARG A  17
ASP A  35
GLY A  36
ASP A  22
 SO4  A 306 (-2.8A)
MN  A 302 ( 2.6A)
MG  A 301 (-4.1A)
MN  A 302 ( 4.8A)
 1.33A 5hp1A-2jftA:
undetectable		 5hp1A-2jftA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ml1 POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 6

(Azotobacter
vinelandii) 		PF00353
(HemolysinCabind) 		4 ASP A  62
GLY A  39
ASP A  26
ASP A  73
 CA  A 205 (-3.3A)
CA  A 205 (-4.2A)
CA  A 201 ( 2.5A)
CA  A 205 (-2.2A)
 1.33A 5hp1A-2ml1A:
undetectable		 5hp1A-2ml1A:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o04 PECTATE LYASE

(Bacillus
subtilis) 		PF00544
(Pec_lyase_C) 		4 ARG A 206
GLY A 142
ASP A 161
ASP A  63
 None
 0.86A 5hp1A-2o04A:
undetectable		 5hp1A-2o04A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o6s VARIABLE LYMPHOCYTE
RECEPTOR B

(Eptatretus
burgeri) 		PF11921
(DUF3439)
PF12799
(LRR_4)
PF13855
(LRR_8) 		4 ARG A 191
ASP A 168
GLY A 165
ASP A 164
 None
 1.06A 5hp1A-2o6sA:
undetectable		 5hp1A-2o6sA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pk0 SERINE/THREONINE
PROTEIN PHOSPHATASE
STP1

(Streptococcus
agalactiae) 		PF13672
(PP2C_2) 		4 ARG A  13
ASP A  36
GLY A  37
ASP A  18
 None
MG  A 502 ( 2.7A)
MG  A 501 (-4.0A)
MG  A 502 ( 4.7A)
 1.31A 5hp1A-2pk0A:
undetectable		 5hp1A-2pk0A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qua EXTRACELLULAR LIPASE

(Serratia
marcescens) 		no annotation 4 ASP A 379
GLY A 377
ASP A 376
ASP A 397
 CA  A 619 (-3.2A)
CA  A 619 (-4.4A)
None
CA  A 619 ( 2.2A)
 1.34A 5hp1A-2quaA:
undetectable		 5hp1A-2quaA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rag DIPEPTIDASE

(Caulobacter
vibrioides) 		PF01244
(Peptidase_M19) 		4 ARG A 333
ASP A 375
GLY A 369
ASP A 368
 None
 1.12A 5hp1A-2ragA:
undetectable		 5hp1A-2ragA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rbi RIBONUCLEASE

(Bacillus
intermedius) 		PF00545
(Ribonuclease) 		4 ARG A  82
GLY A  51
ASP A  74
ASP A  53
 None
 1.33A 5hp1A-2rbiA:
undetectable		 5hp1A-2rbiA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhp THROMBOSPONDIN-2

(Homo sapiens) 		PF02412
(TSP_3)
PF05735
(TSP_C)
PF07645
(EGF_CA)
PF12947
(EGF_3) 		4 ASP A 718
GLY A 699
ASP A1164
ASP A 696
 CA  A  29 ( 2.3A)
None
None
CA  A  28 ( 2.6A)
 1.20A 5hp1A-2rhpA:
undetectable		 5hp1A-2rhpA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w45 ALKALINE EXONUCLEASE

(Human
gammaherpesvirus
4) 		PF01771
(Herpes_alk_exo) 		4 LYS A 231
ARG A 229
GLY A 282
ASP A 283
 None
 1.34A 5hp1A-2w45A:
undetectable		 5hp1A-2w45A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x7j 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE
-1-CARBOXYLATE
SYNTHASE

(Bacillus
subtilis) 		PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
PF16582
(TPP_enzyme_M_2) 		4 ARG A 369
ASP A 412
ASP A 269
ASP A 272
 None
 1.34A 5hp1A-2x7jA:
undetectable		 5hp1A-2x7jA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xf2 CATALASE

(Penicillium
janthinellum) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 ARG A 203
ASP A 561
GLY A 559
ASP A 529
 None
 1.32A 5hp1A-2xf2A:
undetectable		 5hp1A-2xf2A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y6p 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE

(Aquifex
aeolicus) 		PF02348
(CTP_transf_3) 		4 ARG A  15
GLY A 217
ASP A 223
ASP A  95
 CTP  A1233 (-3.7A)
None
None
MG  A1234 ( 2.6A)
 1.15A 5hp1A-2y6pA:
undetectable		 5hp1A-2y6pA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a24 ALPHA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C) 		4 ARG A  51
GLY A 202
ASP A 201
ASP A 198
 None
 1.31A 5hp1A-3a24A:
undetectable		 5hp1A-3a24A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cze SUCROSE HYDROLASE

(Xanthomonas
citri) 		PF00128
(Alpha-amylase) 		4 ARG A 100
ASP A 507
GLY A 503
ASP A 501
 None
 1.13A 5hp1A-3czeA:
undetectable		 5hp1A-3czeA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dnh UNCHARACTERIZED
PROTEIN ATU2129

(Agrobacterium
fabrum) 		PF13883
(Pyrid_oxidase_2) 		4 ARG A  31
GLY A 221
ASP A 220
ASP A 223
 None
 1.31A 5hp1A-3dnhA:
undetectable		 5hp1A-3dnhA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwl ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 2
ACTIN-RELATED
PROTEIN 3

(Schizosaccharomyces
pombe) 		PF00022
(Actin)
PF04045
(P34-Arc) 		4 ARG D 266
ASP A 123
GLY D  36
ASP D  35
 None
 1.04A 5hp1A-3dwlD:
3.1		 5hp1A-3dwlD:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e82 PUTATIVE
OXIDOREDUCTASE

(Klebsiella
pneumoniae) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 ARG A 262
GLY A 282
ASP A 284
ASP A 280
 None
 1.32A 5hp1A-3e82A:
undetectable		 5hp1A-3e82A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g4s 50S RIBOSOMAL
PROTEIN L6P

(Haloarcula
marismortui) 		PF00347
(Ribosomal_L6) 		4 ASP E  25
GLY E  24
ASP E  12
ASP E  10
 None
 1.28A 5hp1A-3g4sE:
5.1		 5hp1A-3g4sE:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ghg FIBRINOGEN GAMMA
CHAIN

(Homo sapiens) 		PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha) 		4 ARG C 247
ASP C 285
GLY C 284
ASP C 261
 ARG  C 247 ( 0.6A)
ASP  C 285 ( 0.6A)
GLY  C 284 ( 0.0A)
ASP  C 261 ( 0.6A)
 1.34A 5hp1A-3ghgC:
undetectable		 5hp1A-3ghgC:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gmg UNCHARACTERIZED
PROTEIN
RV1825/MT1873

(Mycobacterium
tuberculosis) 		PF05949
(DUF881) 		4 ARG A 261
ASP A 186
GLY A 254
ASP A 257
 None
 1.31A 5hp1A-3gmgA:
2.1		 5hp1A-3gmgA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i23 OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY

(Enterococcus
faecalis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 ASP A 252
GLY A 299
ASP A 300
ASP A 128
 None
 0.97A 5hp1A-3i23A:
undetectable		 5hp1A-3i23A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1t GLUTAMATE--CYSTEINE
LIGASE GSHA

(Methylobacillus
flagellatus) 		PF08886
(GshA) 		4 LYS A 207
ARG A 205
GLY A 181
ASP A 178
 None
 1.33A 5hp1A-3k1tA:
undetectable		 5hp1A-3k1tA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kd6 CARBOHYDRATE KINASE,
PFKB FAMILY

(Chlorobaculum
tepidum) 		PF00294
(PfkB) 		4 ARG A  94
ASP A 147
GLY A 236
ASP A 237
 AMP  A 509 (-2.7A)
GOL  A 501 (-3.2A)
GOL  A 501 ( 3.2A)
AMP  A 509 ( 3.3A)
 1.07A 5hp1A-3kd6A:
undetectable		 5hp1A-3kd6A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kdj PROTEIN PHOSPHATASE
2C 56

(Arabidopsis
thaliana) 		PF00481
(PP2C) 		4 ARG B 138
ASP B 347
GLY B 348
ASP B 351
 None
MN  B 435 (-2.9A)
None
None
 1.23A 5hp1A-3kdjB:
undetectable		 5hp1A-3kdjB:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kom TRANSKETOLASE

(Francisella
tularensis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 ARG A   7
ASP A 219
GLY A 220
ASP A  37
 None
 1.30A 5hp1A-3komA:
2.1		 5hp1A-3komA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nm1 THIAMINE
BIOSYNTHETIC
BIFUNCTIONAL ENZYME

([Candida]
glabrata) 		PF02110
(HK)
PF02581
(TMP-TENI) 		4 LYS A 146
ASP A  95
GLY A  92
ASP A  76
 POP  A 543 (-2.9A)
MG  A 544 ( 2.6A)
POP  A 543 (-2.9A)
MG  A 544 ( 3.2A)
 1.30A 5hp1A-3nm1A:
undetectable		 5hp1A-3nm1A:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3okz PUTATIVE
UNCHARACTERIZED
PROTEIN GBS0355

(Streptococcus
agalactiae) 		PF03816
(LytR_cpsA_psr) 		4 ARG A 225
ASP A 219
GLY A 218
ASP A 215
 None
 1.11A 5hp1A-3okzA:
1.0		 5hp1A-3okzA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p4g ANTIFREEZE PROTEIN

(Marinomonas
primoryensis) 		no annotation 4 ASP A 219
GLY A 214
ASP A 213
ASP A 200
 CA  A 409 ( 2.4A)
CA  A 409 (-4.5A)
None
CA  A 408 ( 2.4A)
 1.24A 5hp1A-3p4gA:
undetectable		 5hp1A-3p4gA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rim TRANSKETOLASE

(Mycobacterium
tuberculosis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 ARG A 123
ASP A 484
GLY A 544
ASP A 482
 None
 1.24A 5hp1A-3rimA:
undetectable		 5hp1A-3rimA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rim TRANSKETOLASE

(Mycobacterium
tuberculosis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 ARG A 123
GLY A 544
ASP A 482
ASP A 484
 None
 1.29A 5hp1A-3rimA:
undetectable		 5hp1A-3rimA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ru8 EPITOPE SCAFFOLD
2BODX43

(Human
immunodeficiency
virus;
Thermobifida
fusca;
synthetic
construct) 		PF01341
(Glyco_hydro_6) 		4 LYS X 247
ARG X 209
GLY X 254
ASP X 221
 GOL  X 284 (-2.9A)
None
None
None
 1.23A 5hp1A-3ru8X:
undetectable		 5hp1A-3ru8X:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1

(Bos taurus) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF08282
(Hydrolase_3)
PF13246
(Cation_ATPase) 		4 ARG A 559
ASP A 702
GLY A 354
ASP A 351
 ACP  A1001 (-3.2A)
MG  A1005 (-2.2A)
MG  A1005 ( 4.6A)
ACP  A1001 ( 2.3A)
 1.07A 5hp1A-3tlmA:
undetectable		 5hp1A-3tlmA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ugs UNDECAPRENYL
PYROPHOSPHATE
SYNTHASE

(Campylobacter
jejuni) 		no annotation 4 ARG B 144
ASP B  99
GLY B  98
ASP B 136
 None
 1.25A 5hp1A-3ugsB:
undetectable		 5hp1A-3ugsB:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		4 ARG A  71
ASP A 412
GLY A 401
ASP A  33
 22E  A 500 ( 4.0A)
None
None
22E  A 500 (-3.6A)
 1.31A 5hp1A-4aw2A:
undetectable		 5hp1A-4aw2A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bgb PUTATIVE SUGAR
KINASE MK0840

(Methanopyrus
kandleri) 		PF03702
(AnmK) 		4 ASP A 114
GLY A 137
ASP A 138
ASP A 144
 K  A1357 ( 3.8A)
None
K  A1356 (-3.7A)
K  A1357 ( 2.4A)
 1.24A 5hp1A-4bgbA:
3.8		 5hp1A-4bgbA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bom ENVELOPE
GLYCOPROTEIN B

(Human
alphaherpesvirus
1) 		PF00606
(Glycoprotein_B)
PF17416
(Glycoprot_B_PH1)
PF17417
(Glycoprot_B_PH2) 		4 ARG A 360
GLY A 410
ASP A 411
ASP A 408
 None
 1.27A 5hp1A-4bomA:
2.1		 5hp1A-4bomA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cu5 ENDOLYSIN

(Clostridium
virus phiCD27) 		no annotation 4 LYS A 240
GLY A 195
ASP A 218
ASP A 198
 None
 1.30A 5hp1A-4cu5A:
undetectable		 5hp1A-4cu5A:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fe9 OUTER MEMBRANE
PROTEIN SUSF

(Bacteroides
thetaiotaomicron) 		PF16411
(SusF_SusE)
PF17142
(DUF5115) 		4 ARG A 266
ASP A 233
GLY A 236
ASP A 237
 None
 1.15A 5hp1A-4fe9A:
undetectable		 5hp1A-4fe9A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h7o SERINE
ACETYLTRANSFERASE

(Vibrio cholerae) 		PF00132
(Hexapep)
PF06426
(SATase_N) 		4 ARG A 115
ASP A 172
GLY A 153
ASP A  84
 None
 1.19A 5hp1A-4h7oA:
undetectable		 5hp1A-4h7oA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzc CYSE, SERINE
ACETYLTRANSFERASE

(Brucella
abortus) 		PF00132
(Hexapep)
PF06426
(SATase_N) 		4 ARG A 125
ASP A 182
GLY A 163
ASP A  94
 None
 1.28A 5hp1A-4hzcA:
undetectable		 5hp1A-4hzcA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcm CYCLODEXTRIN
GLUCANOTRANSFERASE

([Bacillus]
clarkii) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		4 ARG A 117
ASP A  53
GLY A 110
ASP A 111
 None
CA  A 701 (-3.4A)
None
GOL  A 736 (-4.1A)
 1.13A 5hp1A-4jcmA:
undetectable		 5hp1A-4jcmA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcm CYCLODEXTRIN
GLUCANOTRANSFERASE

([Bacillus]
clarkii) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		4 ARG A 117
GLY A 110
ASP A 111
ASP A  53
 None
None
GOL  A 736 (-4.1A)
CA  A 701 (-3.4A)
 1.29A 5hp1A-4jcmA:
undetectable		 5hp1A-4jcmA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Mus musculus) 		PF00069
(Pkinase) 		4 ARG A 574
GLY A 410
ASP A 409
ASP A 411
 None
 1.22A 5hp1A-4jlcA:
4.5		 5hp1A-4jlcA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mlg BETA-XYLOSIDASE

(uncultured
organism) 		PF04616
(Glyco_hydro_43) 		4 LYS A 102
ARG A  81
GLY A  43
ASP A  44
 None
 1.32A 5hp1A-4mlgA:
undetectable		 5hp1A-4mlgA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0g PROTEIN PHOSPHATASE
2C 37

(Arabidopsis
thaliana) 		PF00481
(PP2C) 		4 ARG A 114
ASP A 327
GLY A 328
ASP A 331
 None
MG  A 403 ( 3.0A)
None
MG  A 405 (-2.0A)
 1.24A 5hp1A-4n0gA:
undetectable		 5hp1A-4n0gA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n4u PUTATIVE ABC
TRANSPORTER
PERIPLASMIC
SOLUTE-BINDING
PROTEIN

(Bordetella
bronchiseptica) 		PF03480
(DctP) 		4 ARG A 103
ASP A  89
GLY A 230
ASP A 229
 None
 1.17A 5hp1A-4n4uA:
undetectable		 5hp1A-4n4uA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6m AF2299, A
CDP-ALCOHOL
PHOSPHOTRANSFERASE

(Archaeoglobus
fulgidus) 		PF01066
(CDP-OH_P_transf) 		4 LYS A 148
ASP A 214
GLY A 215
ASP A 235
 SO4  A 411 (-4.9A)
CA  A 401 (-2.7A)
CA  A 401 ( 4.7A)
CA  A 401 (-2.2A)
 1.24A 5hp1A-4o6mA:
undetectable		 5hp1A-4o6mA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oic PROBABLE PROTEIN
PHOSPHATASE 2C 6

(Oryza sativa) 		PF00481
(PP2C) 		4 ARG B 159
ASP B 386
GLY B 387
ASP B 390
 None
MN  B 501 ( 2.9A)
None
MN  B 503 (-2.3A)
 1.11A 5hp1A-4oicB:
undetectable		 5hp1A-4oicB:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oxi ENTEROBACTIN
SYNTHETASE COMPONENT
F-RELATED PROTEIN

(Vibrio cholerae) 		PF00501
(AMP-binding) 		4 LYS A 271
ARG A  86
ASP A 243
ASP A 252
 None
 1.30A 5hp1A-4oxiA:
undetectable		 5hp1A-4oxiA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4raf PROTEIN PHOSPHATASE
1A

(Homo sapiens) 		PF00481
(PP2C)
PF07830
(PP2C_C) 		4 ARG A  33
ASP A 239
GLY A 240
ASP A 243
 None
MN  A 401 (-2.6A)
MN  A 401 ( 4.8A)
None
 1.27A 5hp1A-4rafA:
undetectable		 5hp1A-4rafA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tuf MAJOR EXTRACELLULAR
ENDOGLUCANASE

(Xanthomonas
campestris) 		PF00150
(Cellulase) 		4 ARG A 358
ASP A 266
GLY A 311
ASP A 315
 None
 0.93A 5hp1A-4tufA:
undetectable		 5hp1A-4tufA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x0q DNA POLYMERASE THETA

(Homo sapiens) 		PF00476
(DNA_pol_A) 		4 LYS A2383
ARG A2379
ASP A2540
ASP A2330
 DG3  A2604 (-2.5A)
DG3  A2604 (-3.4A)
MG  A2603 ( 2.6A)
MG  A2603 ( 2.3A)
 1.29A 5hp1A-4x0qA:
4.7		 5hp1A-4x0qA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ydw DARPIN 44C12V5

(synthetic
construct) 		PF12796
(Ank_2)
PF13637
(Ank_4) 		4 ASP A  44
GLY A  47
ASP A  77
ASP A  45
 None
 1.26A 5hp1A-4ydwA:
undetectable		 5hp1A-4ydwA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzg PROTEIN PHOSPHATASE
2C 57

(Arabidopsis
thaliana) 		PF00481
(PP2C) 		4 ARG A  69
ASP A 296
GLY A 297
ASP A 300
 SO4  A 403 (-2.6A)
MN  A 402 (-2.6A)
None
None
 1.23A 5hp1A-4yzgA:
undetectable		 5hp1A-4yzgA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5afu DYNACTIN

(Sus scrofa) 		PF00022
(Actin) 		4 ARG A 192
ASP A 162
GLY A 187
ASP A 189
 None
ADP  A 800 ( 3.2A)
ADP  A 800 ( 4.7A)
None
 1.34A 5hp1A-5afuA:
undetectable		 5hp1A-5afuA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5anp BA41

(Bizionia
argentinensis) 		PF04536
(TPM_phosphatase) 		4 ASP A 162
GLY A 164
ASP A 147
ASP A 166
 None
 1.30A 5hp1A-5anpA:
undetectable		 5hp1A-5anpA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gll GLYCOSIDE HYDROLASE
FAMILY 43

(uncultured
bacterium) 		PF04616
(Glyco_hydro_43) 		4 LYS A 143
ARG A 122
GLY A  85
ASP A  86
 None
None
ACT  A 405 ( 4.2A)
None
 1.33A 5hp1A-5gllA:
undetectable		 5hp1A-5gllA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gn5 GLYCEROL KINASE

(Trypanosoma
brucei) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 ASP A 186
GLY A 253
ASP A 254
ASP A 170
 None
None
GOL  A 602 (-2.5A)
None
 1.19A 5hp1A-5gn5A:
4.1		 5hp1A-5gn5A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw4 T-COMPLEX PROTEIN 1
SUBUNIT GAMMA

(Saccharomyces
cerevisiae) 		PF00118
(Cpn60_TCP1) 		4 ARG g 394
ASP g  86
GLY g  90
ASP g 398
 None
 1.23A 5hp1A-5gw4g:
undetectable		 5hp1A-5gw4g:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kvu ISOCITRATE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF03971
(IDH) 		4 LYS A 154
ARG A 158
ASP A 540
GLY A 538
 None
 1.17A 5hp1A-5kvuA:
undetectable		 5hp1A-5kvuA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l2e GLUTAMATE RECEPTOR
IONOTROPIC,
DELTA-2,GLUTAMATE
RECEPTOR IONOTROPIC,
DELTA-2

(Rattus
norvegicus) 		PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		4 ARG A 229
ASP A 796
GLY A 795
ASP A 255
 None
 1.11A 5hp1A-5l2eA:
2.1		 5hp1A-5l2eA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ndl CRH-LIKE PROTEIN

(Aspergillus
fumigatus) 		no annotation 4 ASP A 118
GLY A 138
ASP A 141
ASP A 116
 None
 1.29A 5hp1A-5ndlA:
undetectable		 5hp1A-5ndlA:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ndl CRH-LIKE PROTEIN

(Aspergillus
fumigatus) 		no annotation 4 ASP A 118
GLY A 140
ASP A 141
ASP A 116
 None
 1.27A 5hp1A-5ndlA:
undetectable		 5hp1A-5ndlA:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opt 40S RIBOSOMAL
PROTEIN S2, PUTATIVE
40S RIBOSOMAL
PROTEIN S21,
PUTATIVE

(Trypanosoma
cruzi) 		no annotation 4 LYS d 154
ASP g  15
GLY g   5
ASP d 235
 None
 1.34A 5hp1A-5optd:
undetectable		 5hp1A-5optd:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opt 40S RIBOSOMAL
PROTEIN S2, PUTATIVE
40S RIBOSOMAL
PROTEIN S21,
PUTATIVE

(Trypanosoma
cruzi) 		no annotation 4 LYS d 154
GLY g   5
ASP d 235
ASP g  15
 None
 1.12A 5hp1A-5optd:
undetectable		 5hp1A-5optd:
17.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ovn POL PROTEIN

(Feline
immunodeficiency
virus) 		no annotation 4 ASP A 109
GLY A 111
ASP A 112
ASP A 184
 None
 1.32A 5hp1A-5ovnA:
27.9		 5hp1A-5ovnA:
55.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj6 GLYCOSYL HYDROLASES
FAMILY 2, SUGAR
BINDING DOMAIN
PROTEIN

(Bacteroides
uniformis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF11721
(Malectin)
PF16355
(DUF4982) 		4 ARG A 403
ASP A 159
GLY A 396
ASP A 399
 None
 1.18A 5hp1A-5uj6A:
undetectable		 5hp1A-5uj6A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujz HEMAGGLUTININ HA1
HEMAGGLUTININ HA2

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 ARG A 311
GLY B 587
ASP B 590
ASP B 585
 None
 1.24A 5hp1A-5ujzA:
undetectable		 5hp1A-5ujzA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ukh UNCHARACTERIZED
PROTEIN

(Streptococcus
intermedius) 		no annotation 4 ASP A 454
GLY A 452
ASP A 537
ASP A 455
 CA  A 601 (-3.1A)
None
None
CA  A 601 (-2.3A)
 1.02A 5hp1A-5ukhA:
undetectable		 5hp1A-5ukhA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vjw RHIZOBIALES-LIKE
PHOSPHATASE 2

(Arabidopsis
thaliana) 		no annotation 4 ARG A 245
ASP A  13
GLY A 283
ASP A  47
 WO4  A 403 (-2.5A)
ZN  A 402 (-3.1A)
None
ZN  A 401 (-2.7A)
 1.25A 5hp1A-5vjwA:
undetectable		 5hp1A-5vjwA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ar3 GSI-IIC RT

(Geobacillus
stearothermophilus) 		no annotation 4 LYS A  69
ARG A  75
ASP A 138
ASP A 223
 DTP  A 501 (-2.9A)
DTP  A 501 (-4.0A)
MG  A 502 ( 2.8A)
MG  A 502 ( 2.9A)
 1.08A 5hp1A-6ar3A:
9.6		 5hp1A-6ar3A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b0t FASCIN

(Homo sapiens) 		no annotation 4 ARG A 398
ASP A 473
GLY A 476
ASP A 405
 None
 1.30A 5hp1A-6b0tA:
undetectable		 5hp1A-6b0tA:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c4m YERSINOPINE
DEHYDROGENASE

(Yersinia pestis) 		no annotation 4 ARG C 411
GLY C 284
ASP C 281
ASP C 288
 None
 1.03A 5hp1A-6c4mC:
undetectable		 5hp1A-6c4mC:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6k POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Acinetobacter
baumannii) 		no annotation 4 ASP A 488
GLY A 491
ASP A 492
ASP A 494
 None
 1.33A 5hp1A-6d6kA:
undetectable		 5hp1A-6d6kA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fao GLYCOSIDE HYDROLASE
FAMILY 6

(metagenome) 		no annotation 4 LYS A 261
ARG A 222
GLY A 268
ASP A 235
 EDO  A 301 (-2.8A)
None
None
None
 1.21A 5hp1A-6faoA:
undetectable		 5hp1A-6faoA:
8.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fea NITROGENASE PROTEIN
ALPHA CHAIN
VANADIUM
NITROGENASE, DELTA
SUBUNIT, VNFG

(Azotobacter
vinelandii) 		no annotation 4 ARG C  16
ASP A 350
GLY A 283
ASP A 280
 None
 1.10A 5hp1A-6feaC:
undetectable		 5hp1A-6feaC:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g3u -

(-) 		no annotation 4 LYS A 153
ARG A 157
ASP A 537
GLY A 535
 None
 1.32A 5hp1A-6g3uA:
undetectable		 5hp1A-6g3uA:
undetectable