SIMILAR PATTERNS OF AMINO ACIDS FOR 5HNZ_B_TA1B902_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aor ALDEHYDE FERREDOXIN
OXIDOREDUCTASE

(Pyrococcus
furiosus) 		PF01314
(AFOR_C)
PF02730
(AFOR_N) 		3 LEU A 510
LEU A 493
ARG A 222
 None
 0.61A 5hnzB-1aorA:
undetectable		 5hnzB-1aorA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxc XYLOSE ISOMERASE

(Thermus
caldophilus) 		PF01261
(AP_endonuc_2) 		3 LEU A 128
LEU A  78
ARG A   9
 None
 0.33A 5hnzB-1bxcA:
undetectable		 5hnzB-1bxcA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cja PROTEIN
(ACTIN-FRAGMIN
KINASE)

(Physarum
polycephalum) 		PF09192
(Act-Frag_cataly) 		3 LEU A 170
LEU A 190
ARG A 224
 None
 0.63A 5hnzB-1cjaA:
undetectable		 5hnzB-1cjaA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cnv CONCANAVALIN B

(Canavalia
ensiformis) 		PF00704
(Glyco_hydro_18) 		3 LEU A 118
LEU A  81
ARG A  44
 None
 0.66A 5hnzB-1cnvA:
undetectable		 5hnzB-1cnvA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1t LYSYL-TRNA
SYNTHETASE, HEAT
INDUCIBLE

(Escherichia
coli) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		3 LEU A 429
LEU A 464
ARG A 236
 None
 0.58A 5hnzB-1e1tA:
undetectable		 5hnzB-1e1tA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1evs ONCOSTATIN M

(Homo sapiens) 		PF01291
(LIF_OSM) 		3 LEU A  30
LEU A  85
ARG A  52
 None
 0.49A 5hnzB-1evsA:
undetectable		 5hnzB-1evsA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ex0 COAGULATION FACTOR
XIII A CHAIN

(Homo sapiens) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		3 LEU A 598
LEU A 529
ARG A 661
 None
 0.64A 5hnzB-1ex0A:
undetectable		 5hnzB-1ex0A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE,
GLYCOSOMAL

(Trypanosoma
brucei) 		PF00274
(Glycolytic) 		3 LEU A  87
LEU A  73
ARG A 313
 None
 0.61A 5hnzB-1f2jA:
undetectable		 5hnzB-1f2jA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ff9 SACCHAROPINE
REDUCTASE

(Magnaporthe
grisea) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		3 LEU A 360
LEU A 125
ARG A 355
 None
 0.59A 5hnzB-1ff9A:
4.5		 5hnzB-1ff9A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gxl CHROMOSOME
SEGREGATION SMC
PROTEIN

(Thermotoga
maritima) 		PF06470
(SMC_hinge) 		3 LEU A 613
LEU A 571
ARG A 650
 None
 0.66A 5hnzB-1gxlA:
undetectable		 5hnzB-1gxlA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyt CYTOSOL
AMINOPEPTIDASE

(Escherichia
coli) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		3 LEU A 388
LEU A 420
ARG A 443
 None
 0.59A 5hnzB-1gytA:
undetectable		 5hnzB-1gytA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h0h FORMATE
DEHYDROGENASE
SUBUNIT ALPHA

(Desulfovibrio
gigas) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		3 LEU A 608
LEU A  92
ARG A 103
 None
 0.54A 5hnzB-1h0hA:
1.8		 5hnzB-1h0hA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1im8 YECO

(Haemophilus
influenzae) 		PF13649
(Methyltransf_25) 		3 LEU A 145
LEU A 130
ARG A 166
 None
 0.65A 5hnzB-1im8A:
3.1		 5hnzB-1im8A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1inp INOSITOL
POLYPHOSPHATE
1-PHOSPHATASE

(Bos taurus) 		PF00459
(Inositol_P) 		3 LEU A  56
LEU A  96
ARG A  10
 None
 0.63A 5hnzB-1inpA:
undetectable		 5hnzB-1inpA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itk CATALASE-PEROXIDASE

(Haloarcula
marismortui) 		PF00141
(peroxidase) 		3 LEU A 687
LEU A 651
ARG A 694
 None
 0.66A 5hnzB-1itkA:
undetectable		 5hnzB-1itkA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itu RENAL DIPEPTIDASE

(Homo sapiens) 		PF01244
(Peptidase_M19) 		3 LEU A 208
LEU A 196
ARG A 182
 None
 0.64A 5hnzB-1ituA:
undetectable		 5hnzB-1ituA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iuf CENTROMERE ABP1
PROTEIN

(Schizosaccharomyces
pombe) 		PF03221
(HTH_Tnp_Tc5) 		3 LEU A  54
LEU A  33
ARG A   7
 None
 0.50A 5hnzB-1iufA:
undetectable		 5hnzB-1iufA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ixr RUVB

(Thermus
thermophilus) 		PF05491
(RuvB_C)
PF05496
(RuvB_N) 		3 LEU C  54
LEU C 165
ARG C 209
 None
 0.60A 5hnzB-1ixrC:
undetectable		 5hnzB-1ixrC:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jgs MULTIPLE ANTIBIOTIC
RESISTANCE PROTEIN
MARR

(Escherichia
coli) 		PF01047
(MarR) 		3 LEU A  60
LEU A  75
ARG A  94
 None
SAL  A 256 ( 4.6A)
None
 0.62A 5hnzB-1jgsA:
undetectable		 5hnzB-1jgsA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqo PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Zea mays) 		PF00311
(PEPcase) 		3 LEU A 318
LEU A 450
ARG A 388
 None
 0.64A 5hnzB-1jqoA:
2.0		 5hnzB-1jqoA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqo PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Zea mays) 		PF00311
(PEPcase) 		3 LEU A 544
LEU A 581
ARG A 456
 None
 0.45A 5hnzB-1jqoA:
2.0		 5hnzB-1jqoA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m5y SURVIVAL PROTEIN
SURA

(Escherichia
coli) 		PF00639
(Rotamase)
PF09312
(SurA_N)
PF13616
(Rotamase_3) 		3 LEU A 226
LEU A  66
ARG A  57
 None
 0.47A 5hnzB-1m5yA:
undetectable		 5hnzB-1m5yA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mlz 7,8-DIAMINO-PELARGON
IC ACID
AMINOTRANSFERASE

(Escherichia
coli) 		PF00202
(Aminotran_3) 		3 LEU A 399
LEU A 347
ARG A 221
 None
 0.57A 5hnzB-1mlzA:
undetectable		 5hnzB-1mlzA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n97 CYP175A1

(Thermus
thermophilus) 		PF00067
(p450) 		3 LEU A 219
LEU A 190
ARG A  77
 None
 0.48A 5hnzB-1n97A:
undetectable		 5hnzB-1n97A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o1y CONSERVED
HYPOTHETICAL PROTEIN
TM1158

(Thermotoga
maritima) 		PF00117
(GATase) 		3 LEU A 220
LEU A 170
ARG A 131
 None
None
SO4  A 404 (-3.1A)
 0.53A 5hnzB-1o1yA:
undetectable		 5hnzB-1o1yA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o99 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Geobacillus
stearothermophilus) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		3 LEU A 487
LEU A   8
ARG A 348
 None
 0.65A 5hnzB-1o99A:
1.7		 5hnzB-1o99A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o9r AGROBACTERIUM
TUMEFACIENS DPS

(Agrobacterium
tumefaciens) 		PF00210
(Ferritin) 		3 LEU A  62
LEU A 147
ARG A  72
 None
 0.56A 5hnzB-1o9rA:
undetectable		 5hnzB-1o9rA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oyj GLUTATHIONE
S-TRANSFERASE

(Oryza sativa) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		3 LEU A 115
LEU A 144
ARG A 105
 None
 0.62A 5hnzB-1oyjA:
undetectable		 5hnzB-1oyjA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q15 CARA

(Pectobacterium
carotovorum) 		PF00733
(Asn_synthase)
PF09147
(DUF1933) 		3 LEU A  55
LEU A  59
ARG A  91
 None
 0.65A 5hnzB-1q15A:
undetectable		 5hnzB-1q15A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Escherichia
coli) 		PF00311
(PEPcase) 		3 LEU A 484
LEU A 521
ARG A 396
 None
 0.60A 5hnzB-1qb4A:
2.4		 5hnzB-1qb4A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qw1 DIPHTHERIA TOXIN
REPRESSOR

(Corynebacterium
diphtheriae) 		no annotation 3 LEU A 120
LEU A 217
ARG A 125
 None
 0.53A 5hnzB-1qw1A:
undetectable		 5hnzB-1qw1A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qzm ATP-DEPENDENT
PROTEASE LA

(Escherichia
coli) 		no annotation 3 LEU A 551
LEU A 521
ARG A 504
 None
 0.58A 5hnzB-1qzmA:
undetectable		 5hnzB-1qzmA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qzz ACLACINOMYCIN-10-HYD
ROXYLASE

(Streptomyces
purpurascens) 		PF00891
(Methyltransf_2) 		3 LEU A 202
LEU A 230
ARG A 184
 None
 0.65A 5hnzB-1qzzA:
2.5		 5hnzB-1qzzA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r9j TRANSKETOLASE

(Leishmania
mexicana) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		3 LEU A 370
LEU A 505
ARG A 332
 None
 0.66A 5hnzB-1r9jA:
undetectable		 5hnzB-1r9jA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rpn GDP-MANNOSE
4,6-DEHYDRATASE

(Pseudomonas
aeruginosa) 		PF16363
(GDP_Man_Dehyd) 		3 LEU A  32
LEU A 108
ARG A   3
 None
 0.61A 5hnzB-1rpnA:
7.3		 5hnzB-1rpnA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ser PROTEIN (SERYL-TRNA
SYNTHETASE
(E.C.6.1.1.11))

(Thermus
thermophilus) 		PF00587
(tRNA-synt_2b)
PF02403
(Seryl_tRNA_N) 		3 LEU A   7
LEU A  98
ARG A 363
 None
 0.60A 5hnzB-1serA:
undetectable		 5hnzB-1serA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sk7 HYPOTHETICAL PROTEIN
PA-HO

(Pseudomonas
aeruginosa) 		PF01126
(Heme_oxygenase) 		3 LEU A 109
LEU A  68
ARG A 188
 None
 0.63A 5hnzB-1sk7A:
undetectable		 5hnzB-1sk7A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sma MALTOGENIC AMYLASE

(Thermus sp.
IM6501) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C) 		3 LEU A 228
LEU A 195
ARG A 200
 None
 0.65A 5hnzB-1smaA:
undetectable		 5hnzB-1smaA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sq8 DH434

(Escherichia
virus Lambda) 		PF01381
(HTH_3) 		3 LEU A  60
LEU A  45
ARG A   7
 None
 0.58A 5hnzB-1sq8A:
undetectable		 5hnzB-1sq8A:
8.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 40 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF13177
(DNA_pol3_delta2) 		3 LEU E 113
LEU E  94
ARG E 134
 None
 0.58A 5hnzB-1sxjE:
undetectable		 5hnzB-1sxjE:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tjr BX1

(Zea mays) 		PF00290
(Trp_syntA) 		3 LEU A 135
LEU A 170
ARG A  87
 None
 0.64A 5hnzB-1tjrA:
undetectable		 5hnzB-1tjrA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u10 PENICILLIN-INSENSITI
VE MUREIN
ENDOPEPTIDASE

(Escherichia
coli) 		PF03411
(Peptidase_M74) 		3 LEU A 163
LEU A  81
ARG A 175
 None
 0.66A 5hnzB-1u10A:
undetectable		 5hnzB-1u10A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6g TIP120 PROTEIN

(Homo sapiens) 		PF08623
(TIP120) 		3 LEU C 181
LEU C 199
ARG C 228
 None
 0.47A 5hnzB-1u6gC:
2.3		 5hnzB-1u6gC:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6g TIP120 PROTEIN

(Homo sapiens) 		PF08623
(TIP120) 		3 LEU C 461
LEU C 469
ARG C 451
 None
 0.56A 5hnzB-1u6gC:
2.3		 5hnzB-1u6gC:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uj2 URIDINE-CYTIDINE
KINASE 2

(Homo sapiens) 		PF00485
(PRK) 		3 LEU A  44
LEU A 229
ARG A  52
 None
 0.64A 5hnzB-1uj2A:
undetectable		 5hnzB-1uj2A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1unl CYCLIN-DEPENDENT
KINASE 5 ACTIVATOR 1

(Homo sapiens) 		PF03261
(CDK5_activator) 		3 LEU D 155
LEU D 226
ARG D 183
 None
 0.56A 5hnzB-1unlD:
undetectable		 5hnzB-1unlD:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1urj MAJOR DNA-BINDING
PROTEIN

(Human
alphaherpesvirus
1) 		PF00747
(Viral_DNA_bp) 		3 LEU A  37
LEU A  55
ARG A 101
 None
 0.55A 5hnzB-1urjA:
undetectable		 5hnzB-1urjA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1urj MAJOR DNA-BINDING
PROTEIN

(Human
alphaherpesvirus
1) 		PF00747
(Viral_DNA_bp) 		3 LEU A 469
LEU A 451
ARG A  40
 None
 0.62A 5hnzB-1urjA:
undetectable		 5hnzB-1urjA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w18 LEVANSUCRASE

(Gluconacetobacter
diazotrophicus) 		PF02435
(Glyco_hydro_68) 		3 LEU A 111
LEU A 454
ARG A 514
 None
 0.61A 5hnzB-1w18A:
undetectable		 5hnzB-1w18A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8j MYOSIN VA

(Gallus gallus) 		PF00063
(Myosin_head) 		3 LEU A 265
LEU A 333
ARG A 219
 None
 0.58A 5hnzB-1w8jA:
undetectable		 5hnzB-1w8jA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wwv CONNECTOR ENHANCER
OF KINASE SUPPRESSOR
OF RAS 1

(Homo sapiens) 		PF00536
(SAM_1) 		3 LEU A  68
LEU A  53
ARG A  24
 None
 0.56A 5hnzB-1wwvA:
undetectable		 5hnzB-1wwvA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wz8 ENOYL-COA HYDRATASE

(Thermus
thermophilus) 		PF00378
(ECH_1) 		3 LEU A  42
LEU A  12
ARG A 105
 None
 0.66A 5hnzB-1wz8A:
undetectable		 5hnzB-1wz8A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xls ORPHAN NUCLEAR
RECEPTOR NR1I3
RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens;
Mus musculus) 		PF00104
(Hormone_recep) 		3 LEU E 322
LEU E 302
ARG A 414
 None
 0.61A 5hnzB-1xlsE:
undetectable		 5hnzB-1xlsE:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y4c MALTOSE BINDING
PROTEIN FUSED WITH
DESIGNED HELICAL
PROTEIN

(Escherichia
coli) 		PF13416
(SBP_bac_8) 		3 LEU A 552
LEU A 611
ARG A 585
 None
 0.66A 5hnzB-1y4cA:
undetectable		 5hnzB-1y4cA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygp YEAST GLYCOGEN
PHOSPHORYLASE

(Saccharomyces
cerevisiae) 		PF00343
(Phosphorylase) 		3 LEU A 293
LEU A 344
ARG A 220
 None
 0.51A 5hnzB-1ygpA:
0.4		 5hnzB-1ygpA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yrg GTPASE-ACTIVATING
PROTEIN RNA1_SCHPO

(Schizosaccharomyces
pombe) 		no annotation 3 LEU A 129
LEU A 118
ARG A 162
 None
 0.56A 5hnzB-1yrgA:
undetectable		 5hnzB-1yrgA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6t APOPTOTIC PROTEASE
ACTIVATING FACTOR 1

(Homo sapiens) 		PF00619
(CARD)
PF00931
(NB-ARC) 		3 LEU A  16
LEU A  75
ARG A  44
 None
 0.56A 5hnzB-1z6tA:
undetectable		 5hnzB-1z6tA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zcz BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Thermotoga
maritima) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		3 LEU A   8
LEU A  18
ARG A  79
 None
 0.64A 5hnzB-1zczA:
undetectable		 5hnzB-1zczA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zoq INTERFERON
REGULATORY FACTOR 3

(Homo sapiens) 		PF10401
(IRF-3) 		3 LEU A 322
LEU A 372
ARG A 338
 None
 0.60A 5hnzB-1zoqA:
undetectable		 5hnzB-1zoqA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zup HYPOTHETICAL PROTEIN
TM1739

(Thermotoga
maritima) 		PF09376
(NurA) 		3 LEU A 257
LEU A 233
ARG A  37
 None
 0.49A 5hnzB-1zupA:
undetectable		 5hnzB-1zupA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aj4 GALACTOKINASE

(Saccharomyces
cerevisiae) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		3 LEU A 402
LEU A 343
ARG A 277
 None
 0.55A 5hnzB-2aj4A:
undetectable		 5hnzB-2aj4A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bv7 GLYCOLIPID TRANSFER
PROTEIN

(Bos taurus) 		PF08718
(GLTP) 		3 LEU A 101
LEU A  30
ARG A 181
 None
GM3  A1212 ( 4.8A)
None
 0.58A 5hnzB-2bv7A:
undetectable		 5hnzB-2bv7A:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4t 5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE

(Streptomyces
cattleya) 		PF01887
(SAM_adeno_trans) 		3 LEU A 267
LEU A 250
ARG A 277
 None
 0.53A 5hnzB-2c4tA:
undetectable		 5hnzB-2c4tA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cjw GTP-BINDING PROTEIN
GEM

(Homo sapiens) 		PF00071
(Ras) 		3 LEU A  91
LEU A 231
ARG A  77
 None
 0.63A 5hnzB-2cjwA:
2.1		 5hnzB-2cjwA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cxh PROBABLE BRIX-DOMAIN
RIBOSOMAL BIOGENESIS
PROTEIN

(Aeropyrum
pernix) 		no annotation 3 LEU A  35
LEU A 182
ARG A 109
 None
 0.48A 5hnzB-2cxhA:
undetectable		 5hnzB-2cxhA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1c ISOCITRATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00180
(Iso_dh) 		3 LEU A 462
LEU A 477
ARG A 471
 None
 0.66A 5hnzB-2d1cA:
undetectable		 5hnzB-2d1cA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epj GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Aeropyrum
pernix) 		PF00202
(Aminotran_3) 		3 LEU A 363
LEU A 424
ARG A 331
 None
 0.61A 5hnzB-2epjA:
undetectable		 5hnzB-2epjA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fef HYPOTHETICAL PROTEIN
PA2201

(Pseudomonas
aeruginosa) 		PF08929
(DUF1911) 		3 LEU A 263
LEU A 207
ARG A 231
 None
 0.62A 5hnzB-2fefA:
undetectable		 5hnzB-2fefA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fhp METHYLASE, PUTATIVE

(Enterococcus
faecalis) 		PF03602
(Cons_hypoth95) 		3 LEU A 132
LEU A 119
ARG A 102
 None
 0.53A 5hnzB-2fhpA:
undetectable		 5hnzB-2fhpA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqx MEMBRANE LIPOPROTEIN
TMPC

(Treponema
pallidum) 		PF02608
(Bmp) 		3 LEU A 255
LEU A 302
ARG A 261
 None
 0.58A 5hnzB-2fqxA:
1.9		 5hnzB-2fqxA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g37 PROLINE
DEHYDROGENASE/DELTA-
1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE

(Thermus
thermophilus) 		PF01619
(Pro_dh) 		3 LEU A  45
LEU A  60
ARG A 263
 None
 0.41A 5hnzB-2g37A:
2.8		 5hnzB-2g37A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gd2 PROBABLE
ALPHA-METHYLACYL-COA
RACEMASE MCR

(Mycobacterium
tuberculosis) 		PF02515
(CoA_transf_3) 		3 LEU A 275
LEU A 252
ARG A 233
 None
 0.39A 5hnzB-2gd2A:
undetectable		 5hnzB-2gd2A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2glj PROBABLE M18-FAMILY
AMINOPEPTIDASE 1

(Clostridium
acetobutylicum) 		PF02127
(Peptidase_M18) 		3 LEU A 118
LEU A 225
ARG A  42
 None
 0.60A 5hnzB-2gljA:
undetectable		 5hnzB-2gljA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gs9 HYPOTHETICAL PROTEIN
TT1324

(Thermus
thermophilus) 		PF08241
(Methyltransf_11) 		3 LEU A 182
LEU A  19
ARG A 146
 None
 0.60A 5hnzB-2gs9A:
2.7		 5hnzB-2gs9A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h0a TRANSCRIPTIONAL
REGULATOR

(Thermus
thermophilus) 		PF13377
(Peripla_BP_3) 		3 LEU A 246
LEU A 235
ARG A 331
 None
 0.66A 5hnzB-2h0aA:
undetectable		 5hnzB-2h0aA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h7v PROTEIN KINASE YPKA

(Yersinia
pseudotuberculosis) 		PF09632
(Rac1) 		3 LEU C 693
LEU C 714
ARG C 684
 None
 0.49A 5hnzB-2h7vC:
undetectable		 5hnzB-2h7vC:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iag PROSTACYCLIN
SYNTHASE

(Homo sapiens) 		PF00067
(p450) 		3 LEU A 164
LEU A 464
ARG A 197
 None
 0.56A 5hnzB-2iagA:
undetectable		 5hnzB-2iagA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iag PROSTACYCLIN
SYNTHASE

(Homo sapiens) 		PF00067
(p450) 		3 LEU A 384
LEU A  54
ARG A  25
 None
 0.61A 5hnzB-2iagA:
undetectable		 5hnzB-2iagA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ici EXOTOXIN I

(Streptococcus
pyogenes) 		PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C) 		3 LEU A 146
LEU A 222
ARG A 163
 None
 0.57A 5hnzB-2iciA:
undetectable		 5hnzB-2iciA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iou PERTACTIN
EXTRACELLULAR DOMAIN

(Bordetella
bronchiseptica) 		PF03212
(Pertactin) 		3 LEU G 477
LEU G 497
ARG G 427
 None
 0.62A 5hnzB-2iouG:
undetectable		 5hnzB-2iouG:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ip4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Thermus
thermophilus) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		3 LEU A  15
LEU A 298
ARG A  27
 None
 0.66A 5hnzB-2ip4A:
undetectable		 5hnzB-2ip4A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ixm SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
REGULATORY SUBUNIT
B'

(Homo sapiens) 		PF03095
(PTPA) 		3 LEU A 139
LEU A  84
ARG A 106
 None
 0.66A 5hnzB-2ixmA:
undetectable		 5hnzB-2ixmA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jeo URIDINE-CYTIDINE
KINASE 1

(Homo sapiens) 		PF00485
(PRK) 		3 LEU A  47
LEU A 231
ARG A  55
 None
 0.63A 5hnzB-2jeoA:
undetectable		 5hnzB-2jeoA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kbq HARMONIN

(Homo sapiens) 		no annotation 3 LEU A  26
LEU A  58
ARG A   3
 None
 0.66A 5hnzB-2kbqA:
undetectable		 5hnzB-2kbqA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l7b APOLIPOPROTEIN E

(Homo sapiens) 		PF01442
(Apolipoprotein) 		3 LEU A 159
LEU A  71
ARG A  15
 None
 0.54A 5hnzB-2l7bA:
undetectable		 5hnzB-2l7bA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lak AHSA1-LIKE PROTEIN
RHE_CH02687

(Rhizobium etli) 		PF08327
(AHSA1) 		3 LEU A  27
LEU A 134
ARG A  74
 None
 0.56A 5hnzB-2lakA:
undetectable		 5hnzB-2lakA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lf8 TRANSCRIPTION FACTOR
ETV6

(Mus musculus) 		PF00178
(Ets) 		3 LEU A 344
LEU A 372
ARG A 414
 None
 0.44A 5hnzB-2lf8A:
undetectable		 5hnzB-2lf8A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2x HYPOTHETICAL PROTEIN

(Mesorhizobium
loti) 		PF13242
(Hydrolase_like) 		3 LEU A 157
LEU A 204
ARG A  37
 None
 0.62A 5hnzB-2o2xA:
3.8		 5hnzB-2o2xA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ob1 LEUCINE CARBOXYL
METHYLTRANSFERASE 1

(Saccharomyces
cerevisiae) 		PF04072
(LCM) 		3 LEU A  49
LEU A  13
ARG A 141
 None
 0.40A 5hnzB-2ob1A:
undetectable		 5hnzB-2ob1A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogx MOLYBDENUM STORAGE
PROTEIN SUBUNIT
ALPHA

(Azotobacter
vinelandii) 		PF00696
(AA_kinase) 		3 LEU A  75
LEU A 141
ARG A  66
 None
 0.45A 5hnzB-2ogxA:
undetectable		 5hnzB-2ogxA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p8e PPM1B BETA ISOFORM
VARIANT 6

(Homo sapiens) 		PF00481
(PP2C) 		3 LEU A 268
LEU A 262
ARG A 153
 None
 0.63A 5hnzB-2p8eA:
undetectable		 5hnzB-2p8eA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pl3 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX10

(Homo sapiens) 		PF00270
(DEAD) 		3 LEU A  76
LEU A 104
ARG A  50
 None
 0.46A 5hnzB-2pl3A:
2.6		 5hnzB-2pl3A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2py6 METHYLTRANSFERASE
FKBM

(Methylobacillus
flagellatus) 		PF05050
(Methyltransf_21) 		3 LEU A 393
LEU A 176
ARG A 386
 None
 0.61A 5hnzB-2py6A:
1.3		 5hnzB-2py6A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Homo sapiens) 		PF00348
(polyprenyl_synt) 		3 LEU A 158
LEU A 114
ARG A 278
 None
 0.54A 5hnzB-2q80A:
undetectable		 5hnzB-2q80A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qq8 TBC1 DOMAIN FAMILY
MEMBER 14

(Homo sapiens) 		PF00566
(RabGAP-TBC) 		3 LEU A 398
LEU A 367
ARG A 587
 None
 0.50A 5hnzB-2qq8A:
undetectable		 5hnzB-2qq8A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r3u PROTEASE DEGS

(Escherichia
coli) 		PF13365
(Trypsin_2) 		3 LEU A 138
LEU A 108
ARG A  52
 None
 0.62A 5hnzB-2r3uA:
undetectable		 5hnzB-2r3uA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rk0 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE
DOMAIN

(Frankia sp.
EAN1pec) 		PF00903
(Glyoxalase) 		3 LEU A  76
LEU A  11
ARG A  70
 None
 0.61A 5hnzB-2rk0A:
undetectable		 5hnzB-2rk0A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uvf EXOPOLYGALACTURONASE

(Yersinia
enterocolitica) 		PF00295
(Glyco_hydro_28)
PF12708
(Pectate_lyase_3) 		3 LEU A 201
LEU A 217
ARG A 330
 None
 0.59A 5hnzB-2uvfA:
undetectable		 5hnzB-2uvfA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v5d O-GLCNACASE NAGJ

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C)
PF02838
(Glyco_hydro_20b)
PF07555
(NAGidase) 		3 LEU A 162
LEU A 135
ARG A  83
 None
 0.64A 5hnzB-2v5dA:
1.8		 5hnzB-2v5dA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vak SIGMA A

(Avian
orthoreovirus) 		PF03084
(Sigma_1_2) 		3 LEU A 338
LEU A 229
ARG A 157
 None
 0.56A 5hnzB-2vakA:
undetectable		 5hnzB-2vakA:
22.67