SIMILAR PATTERNS OF AMINO ACIDS FOR 5HNZ_B_TA1B902_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bf2 | ISOAMYLASE (Pseudomonasamyloderamosa) |
PF00128(Alpha-amylase)PF02922(CBM_48) | 5 | VAL A 125LEU A 32ALA A 122SER A 257ARG A 80 | None | 1.41A | 5hnzB-1bf2A:undetectable | 5hnzB-1bf2A:18.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1c7o | CYSTALYSIN (Treponemadenticola) |
PF00155(Aminotran_1_2) | 5 | ASP A 203LEU A 17ASP A 40SER A 248PRO A 100 | PPG A1500 (-3.0A)PPG A1500 (-3.5A)NonePPG A1500 ( 3.9A)None | 1.38A | 5hnzB-1c7oA:3.1 | 5hnzB-1c7oA:21.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j31 | HYPOTHETICAL PROTEINPH0642 (Pyrococcushorikoshii) |
PF00795(CN_hydrolase) | 5 | VAL A 141ASP A 148ALA A 167THR A 87ARG A 112 | None | 1.42A | 5hnzB-1j31A:undetectable | 5hnzB-1j31A:20.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jqo | PHOSPHOENOLPYRUVATECARBOXYLASE (Zea mays) |
PF00311(PEPcase) | 5 | VAL A 307ASP A 306LEU A 559ARG A 556PRO A 301 | None | 1.23A | 5hnzB-1jqoA:undetectable | 5hnzB-1jqoA:17.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kzh | PHOSPHOFRUCTOKINASE (Borreliellaburgdorferi) |
PF00365(PFK) | 5 | LEU A 485HIS A 213SER A 59THR A 483ARG A 42 | None | 1.14A | 5hnzB-1kzhA:undetectable | 5hnzB-1kzhA:20.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lw7 | TRANSCRIPTIONALREGULATOR NADR (Haemophilusinfluenzae) |
PF01467(CTP_transf_like)PF13521(AAA_28) | 5 | ASP A 99SER A 106PHE A 225ARG A 119PRO A 69 | None | 1.42A | 5hnzB-1lw7A:3.2 | 5hnzB-1lw7A:21.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mg5 | ALCOHOLDEHYDROGENASE (Drosophilamelanogaster) |
PF00106(adh_short) | 5 | VAL A 65ASP A 64LEU A 189ALA A 13THR A 188 | NAI A 850 (-3.5A)NAI A 850 (-3.4A)NAI A 850 (-3.3A)NAI A 850 (-3.2A)NAI A 850 ( 4.9A) | 1.35A | 5hnzB-1mg5A:8.7 | 5hnzB-1mg5A:19.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1n5x | XANTHINEDEHYDROGENASE (Bos taurus) |
PF00111(Fer2)PF00941(FAD_binding_5)PF01315(Ald_Xan_dh_C)PF01799(Fer2_2)PF02738(Ald_Xan_dh_C2)PF03450(CO_deh_flav_C) | 5 | GLU A 929SER A 928PHE A1271THR A1301ARG A1306 | None | 1.42A | 5hnzB-1n5xA:undetectable | 5hnzB-1n5xA:15.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q51 | MENB (Mycobacteriumtuberculosis) |
PF00378(ECH_1) | 5 | ASP A 81LEU A 34HIS A 75ALA A 76THR A 38 | None | 1.30A | 5hnzB-1q51A:undetectable | 5hnzB-1q51A:22.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rkt | PROTEIN YFIR (Bacillussubtilis) |
PF00440(TetR_N) | 5 | LEU A 114SER A 55PHE A 30THR A 116ARG A 124 | UNX A 423 ( 4.8A)NoneNoneNoneNone | 1.36A | 5hnzB-1rktA:undetectable | 5hnzB-1rktA:19.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tqy | ACTINORHODINPOLYKETIDE PUTATIVEBETA-KETOACYLSYNTHASE 2 (Streptomycescoelicolor) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | VAL B 293ASP B 292LEU B 165ALA B 345SER B 348 | None | 1.30A | 5hnzB-1tqyB:undetectable | 5hnzB-1tqyB:21.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1txk | GLUCANS BIOSYNTHESISPROTEIN G (Escherichiacoli) |
PF04349(MdoG) | 5 | VAL A 474GLU A 459ALA A 426THR A 486ARG A 489 | None | 1.40A | 5hnzB-1txkA:undetectable | 5hnzB-1txkA:21.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uxi | MALATE DEHYDROGENASE (Chloroflexusaurantiacus) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 5 | VAL A 140LEU A 303ASP A 123ALA A 130SER A 133 | None | 1.31A | 5hnzB-1uxiA:5.8 | 5hnzB-1uxiA:21.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z1w | TRICORN PROTEASEINTERACTING FACTORF3 (Thermoplasmaacidophilum) |
PF01433(Peptidase_M1)PF11838(ERAP1_C) | 5 | VAL A 3ASP A 28GLU A 2ASP A 7ALA A 119 | None | 1.29A | 5hnzB-1z1wA:undetectable | 5hnzB-1z1wA:19.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bfr | HYPOTHETICAL PROTEINAF1521 (Archaeoglobusfulgidus) |
PF01661(Macro) | 5 | VAL A 168LEU A 157PHE A 137THR A 155PRO A 123 | None | 1.19A | 5hnzB-2bfrA:undetectable | 5hnzB-2bfrA:16.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2db3 | ATP-DEPENDENT RNAHELICASE VASA (Drosophilamelanogaster) |
PF00270(DEAD)PF00271(Helicase_C) | 5 | ASP A 399ASP A 572HIS A 575ALA A 433THR A 580 | MG A2801 (-3.4A)NoneNoneANP A2901 ( 3.7A)None | 1.36A | 5hnzB-2db3A:undetectable | 5hnzB-2db3A:22.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ffu | POLYPEPTIDEN-ACETYLGALACTOSAMINYLTRANSFERASE 2 (Homo sapiens) |
PF00535(Glycos_transf_2)PF00652(Ricin_B_lectin) | 5 | LEU A 173ALA A 151SER A 109THR A 143ARG A 197 | NoneNoneNoneUDP A 601 (-3.8A)None | 1.30A | 5hnzB-2ffuA:undetectable | 5hnzB-2ffuA:21.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gdq | YITF (Bacillussubtilis) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | VAL A 144GLU A 148ASP A 170HIS A 173ALA A 176 | None | 1.37A | 5hnzB-2gdqA:2.3 | 5hnzB-2gdqA:22.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i6t | UBIQUITIN-CONJUGATING ENZYME E2-LIKEISOFORM A (Homo sapiens) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 5 | ASP A 352LEU A 446ASP A 449SER A 458THR A 444 | NoneNoneNoneNoneGOL A 11 (-3.8A) | 1.34A | 5hnzB-2i6tA:2.2 | 5hnzB-2i6tA:21.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ix2 | DNA POLYMERASESLIDING CLAMP B (Sulfolobussolfataricus) |
PF00705(PCNA_N) | 5 | VAL A 56ASP A 55LEU A 28SER A 237PHE A 15 | None | 1.38A | 5hnzB-2ix2A:undetectable | 5hnzB-2ix2A:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nz9 | BOTULINUM NEUROTOXINTYPE A (Clostridiumbotulinum) |
PF01742(Peptidase_M27)PF07951(Toxin_R_bind_C)PF07952(Toxin_trans)PF07953(Toxin_R_bind_N) | 5 | VAL A 355ASP A 352GLU A 351LEU A 208PHE A 196 | None | 1.32A | 5hnzB-2nz9A:undetectable | 5hnzB-2nz9A:15.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ovl | PUTATIVE RACEMASE (Streptomycescoelicolor) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | VAL A 301ASP A 303LEU A 20HIS A 321PHE A 31 | None | 1.33A | 5hnzB-2ovlA:undetectable | 5hnzB-2ovlA:20.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qs9 | RETINOBLASTOMA-BINDING PROTEIN 9 (Homo sapiens) |
PF06821(Ser_hydrolase) | 5 | VAL A 90ASP A 66LEU A 174ALA A 92PRO A 4 | None | 1.14A | 5hnzB-2qs9A:3.3 | 5hnzB-2qs9A:15.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wl1 | PYRIN (Homo sapiens) |
PF00622(SPRY)PF13765(PRY) | 5 | VAL A 587LEU A 709HIS A 739SER A 728THR A 707 | NoneNoneNoneNoneSCN A1778 ( 4.7A) | 1.09A | 5hnzB-2wl1A:undetectable | 5hnzB-2wl1A:17.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wp9 | SUCCINATEDEHYDROGENASEIRON-SULFUR SUBUNIT (Escherichiacoli) |
PF13085(Fer2_3)PF13534(Fer4_17) | 5 | ASP B 32LEU B 65ASP B 63ALA B 38PHE B 5 | NoneNoneFES B 302 (-2.2A)NoneNone | 1.18A | 5hnzB-2wp9B:undetectable | 5hnzB-2wp9B:17.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xd4 | PHOSPHORIBOSYLAMINE--GLYCINE LIGASE (Bacillussubtilis) |
PF01071(GARS_A)PF02843(GARS_C)PF02844(GARS_N) | 5 | VAL A 358ASP A 35HIS A 360ALA A 378THR A 344 | None | 1.40A | 5hnzB-2xd4A:undetectable | 5hnzB-2xd4A:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fvw | PUTATIVENAD(P)H-DEPENDENTFMN REDUCTASE (Streptococcusmutans) |
PF03358(FMN_red) | 5 | VAL A 143ASP A 144ASP A 110HIS A 141ALA A 181 | None | 1.33A | 5hnzB-3fvwA:undetectable | 5hnzB-3fvwA:18.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gwf | CYCLOHEXANONEMONOOXYGENASE (Rhodococcus sp.HI-31) |
PF00743(FMO-like) | 5 | GLU A 252LEU A 74ASP A 235ALA A 241SER A 244 | None | 1.29A | 5hnzB-3gwfA:undetectable | 5hnzB-3gwfA:22.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iwj | PUTATIVEAMINOALDEHYDEDEHYDROGENASE (Pisum sativum) |
PF00171(Aldedh) | 5 | VAL A 155ASP A 232LEU A 206ALA A 175PRO A 151 | None | 1.07A | 5hnzB-3iwjA:undetectable | 5hnzB-3iwjA:20.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iwk | AMINOALDEHYDEDEHYDROGENASE (Pisum sativum) |
PF00171(Aldedh) | 5 | VAL A 155ASP A 232LEU A 206ALA A 175PRO A 151 | None | 1.10A | 5hnzB-3iwkA:undetectable | 5hnzB-3iwkA:22.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iwt | 178AA LONGHYPOTHETICALMOLYBDENUM COFACTORBIOSYNTHESIS PROTEINB (Sulfurisphaeratokodaii) |
PF00994(MoCF_biosynth) | 5 | VAL A 62LEU A 106ALA A 72SER A 60ARG A 104 | None | 1.35A | 5hnzB-3iwtA:undetectable | 5hnzB-3iwtA:17.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ju8 | SUCCINYLGLUTAMICSEMIALDEHYDEDEHYDROGENASE (Pseudomonasaeruginosa) |
PF00171(Aldedh) | 5 | VAL A 140ASP A 216LEU A 191ALA A 160PRO A 136 | None | 1.13A | 5hnzB-3ju8A:undetectable | 5hnzB-3ju8A:21.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lm3 | UNCHARACTERIZEDPROTEIN (Parabacteroidesdistasonis) |
PF12979(DUF3863)PF12980(DUF3864) | 5 | GLU A 424LEU A 70ALA A 143SER A 181PRO A 425 | None | 1.42A | 5hnzB-3lm3A:undetectable | 5hnzB-3lm3A:20.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lov | PROTOPORPHYRINOGENOXIDASE (Exiguobacteriumsibiricum) |
PF01593(Amino_oxidase) | 5 | ASP A 369HIS A 307ALA A 175SER A 171THR A 311 | None | 1.23A | 5hnzB-3lovA:undetectable | 5hnzB-3lovA:23.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lsc | TRIAZINE HYDROLASE (Paenarthrobacteraurescens) |
PF01979(Amidohydro_1) | 5 | LEU A 296HIS A 238SER A 161THR A 324ARG A 302 | None ZN A 458 (-3.2A)NoneNoneNone | 1.15A | 5hnzB-3lscA:2.9 | 5hnzB-3lscA:22.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n23 | SODIUM/POTASSIUM-TRANSPORTING ATPASESUBUNIT ALPHA-1 (Sus scrofa) |
PF00122(E1-E2_ATPase)PF00689(Cation_ATPase_C)PF00690(Cation_ATPase_N)PF13246(Cation_ATPase) | 5 | VAL A 734ASP A 733ALA A 264SER A 268THR A 254 | None | 1.07A | 5hnzB-3n23A:2.5 | 5hnzB-3n23A:17.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qk8 | ENOYL-COA HYDRATASEECHA15 (Mycobacteriummarinum) |
PF00378(ECH_1) | 5 | VAL A 33LEU A 235HIS A 38ALA A 117ARG A 85 | NoneNoneUNL A 291 ( 4.0A)UNL A 291 ( 3.3A)None | 1.24A | 5hnzB-3qk8A:undetectable | 5hnzB-3qk8A:20.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r9j | SEPTUMSITE-DETERMININGPROTEIN MIND (Escherichiacoli) |
PF01656(CbiA) | 5 | VAL A 227ALA A 233SER A 216ARG A 251PRO A 212 | None | 1.39A | 5hnzB-3r9jA:5.4 | 5hnzB-3r9jA:20.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rrv | ENOYL-COAHYDRATASE/ISOMERASE (Mycobacteriumavium) |
PF00378(ECH_1) | 5 | VAL A 30ASP A 68ASP A 88SER A 64ARG A 82 | None | 1.41A | 5hnzB-3rrvA:undetectable | 5hnzB-3rrvA:21.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s5s | MANDELATERACEMASE/MUCONATELACTONIZING ENZYMEFAMILY PROTEIN (Sorangiumcellulosum) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | VAL A 236GLU A 235ASP A 194ALA A 204ARG A 227 | None | 1.41A | 5hnzB-3s5sA:3.1 | 5hnzB-3s5sA:21.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sgz | HYDROXYACID OXIDASE2 (Rattusnorvegicus) |
PF01070(FMN_dh) | 5 | GLU A 88LEU A 161ASP A 167SER A 109THR A 158 | NoneHO6 A 402 ( 4.5A)NoneNoneHO6 A 402 ( 4.6A) | 1.35A | 5hnzB-3sgzA:undetectable | 5hnzB-3sgzA:20.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sr6 | XANTHINEDEHYDROGENASE/OXIDASE (Bos taurus) |
PF01315(Ald_Xan_dh_C)PF02738(Ald_Xan_dh_C2) | 5 | GLU C 929SER C 928PHE C1271THR C1301ARG C1306 | None | 1.30A | 5hnzB-3sr6C:undetectable | 5hnzB-3sr6C:20.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v34 | RIBONUCLEASE ZC3H12A (Homo sapiens) |
PF11977(RNase_Zc3h12a) | 5 | VAL A 139ASP A 226ALA A 233SER A 236PHE A 259 | None MG A 1 (-2.8A)NoneNoneNone | 1.27A | 5hnzB-3v34A:undetectable | 5hnzB-3v34A:18.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vc7 | PUTATIVEOXIDOREDUCTASE (Sinorhizobiummeliloti) |
PF13561(adh_short_C2) | 5 | VAL A 134ALA A 229SER A 132PHE A 230ARG A 25 | None | 1.06A | 5hnzB-3vc7A:7.5 | 5hnzB-3vc7A:20.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zus | BOTULINUM NEUROTOXINTYPE A,SYNAPTOSOMAL-ASSOCIATED PROTEIN 23 (Clostridiumbotulinum;Homo sapiens) |
PF01742(Peptidase_M27)PF07952(Toxin_trans) | 5 | VAL A 355ASP A 352GLU A 351LEU A 208PHE A 196 | None | 1.32A | 5hnzB-3zusA:undetectable | 5hnzB-3zusA:18.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zzu | ELONGATION FACTOR G (Staphylococcusaureus) |
PF00009(GTP_EFTU)PF00679(EFG_C)PF03144(GTP_EFTU_D2)PF03764(EFG_IV)PF14492(EFG_II) | 5 | VAL A 630ASP A 631LEU A 658ASP A 622THR A 667 | None | 1.28A | 5hnzB-3zzuA:undetectable | 5hnzB-3zzuA:21.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a0m | BETAINE ALDEHYDEDEHYDROGENASE,CHLOROPLASTIC (Spinaciaoleracea) |
PF00171(Aldedh) | 5 | VAL A 152ASP A 229LEU A 203ALA A 172PRO A 148 | None | 1.00A | 5hnzB-4a0mA:undetectable | 5hnzB-4a0mA:23.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bgf | ARYLAMINEN-ACETYLTRANSFERASENAT (Mycobacteriumtuberculosis) |
PF00797(Acetyltransf_2) | 5 | LEU A 52ASP A 50ALA A 196SER A 202PRO A 107 | None | 1.33A | 5hnzB-4bgfA:undetectable | 5hnzB-4bgfA:22.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4blq | P4 (Pseudomonasphage phi8) |
PF11602(NTPase_P4) | 5 | VAL A 21LEU A 173ALA A 156THR A 214ARG A 174 | None | 1.03A | 5hnzB-4blqA:undetectable | 5hnzB-4blqA:22.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bwy | P4 (Pseudomonasphage phi8) |
PF11602(NTPase_P4) | 5 | VAL A 21LEU A 173ALA A 156THR A 214ARG A 174 | None | 1.04A | 5hnzB-4bwyA:undetectable | 5hnzB-4bwyA:23.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fmc | RORF2 (Escherichiacoli) |
PF06872(EspG) | 5 | VAL A 340LEU A 234ALA A 290SER A 342PHE A 291 | None | 1.28A | 5hnzB-4fmcA:undetectable | 5hnzB-4fmcA:20.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g2b | SECRETED EFFECTORPROTEIN SSEI (Salmonellaenterica) |
PF15645(Tox-PLDMTX) | 5 | ALA A 234SER A 233PHE A 237THR A 264ARG A 261 | None | 1.27A | 5hnzB-4g2bA:undetectable | 5hnzB-4g2bA:17.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i8p | AMINOALDEHYDEDEHYDROGENASE 1 (Zea mays) |
PF00171(Aldedh) | 5 | VAL A 157ASP A 234ALA A 177ARG A 62PRO A 153 | None | 1.40A | 5hnzB-4i8pA:undetectable | 5hnzB-4i8pA:19.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i8p | AMINOALDEHYDEDEHYDROGENASE 1 (Zea mays) |
PF00171(Aldedh) | 5 | VAL A 157ASP A 234LEU A 208ALA A 177PRO A 153 | None | 1.03A | 5hnzB-4i8pA:undetectable | 5hnzB-4i8pA:19.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i8q | PUTATIVE BETAINEALDEHYDEDEHYROGENASE (Solanumlycopersicum) |
PF00171(Aldedh) | 5 | VAL A 155ASP A 232LEU A 206ALA A 175PRO A 151 | None | 0.97A | 5hnzB-4i8qA:undetectable | 5hnzB-4i8qA:22.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4idt | MITOGEN-ACTIVATEDPROTEIN KINASEKINASE KINASE 14 (Homo sapiens) |
PF00069(Pkinase) | 5 | VAL A 338GLU A 334LEU A 433ASP A 376ARG A 366 | None | 1.39A | 5hnzB-4idtA:undetectable | 5hnzB-4idtA:21.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iq4 | NON-HAEMBROMOPEROXIDASEBPO-A2, MATRIXPROTEIN 1 (Influenza Avirus;Kitasatosporaaureofaciens) |
PF00561(Abhydrolase_1)PF00598(Flu_M1) | 5 | VAL A 104LEU A 46ALA A 120PHE A 274ARG A 52 | None | 0.89A | 5hnzB-4iq4A:3.9 | 5hnzB-4iq4A:23.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jqp | 4-HYDROXYTHREONINE-4-PHOSPHATEDEHYDROGENASE (Paraburkholderiaphymatum) |
PF04166(PdxA) | 5 | VAL A 323GLU A 31ASP A 310HIS A 311ALA A 314 | None | 1.33A | 5hnzB-4jqpA:undetectable | 5hnzB-4jqpA:22.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lg9 | F-BOX-LIKE/WDREPEAT-CONTAININGPROTEIN TBL1XR1 (Homo sapiens) |
PF00400(WD40) | 5 | VAL A 352ASP A 369LEU A 415ALA A 354ARG A 425 | None | 1.32A | 5hnzB-4lg9A:undetectable | 5hnzB-4lg9A:19.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lsd | FIBRONECTIN TYPE IIIDOMAIN-CONTAININGPROTEIN 5 (Homo sapiens) |
PF00041(fn3) | 5 | VAL A 59ASP A 56GLU A 55ALA A 104ARG A 40 | None | 1.08A | 5hnzB-4lsdA:undetectable | 5hnzB-4lsdA:10.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m8n | PLEXINC1INTRACELLULAR REGION (Danio rerio) |
PF08337(Plexin_cytopl) | 5 | VAL A1067ASP A 988HIS A 991PHE A 972ARG A 711 | NoneNoneNoneNoneGDP E 201 ( 2.9A) | 1.34A | 5hnzB-4m8nA:undetectable | 5hnzB-4m8nA:20.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mnr | PEPTIDOGLYCANGLYCOSYLTRANSFERASE (Eggerthellalenta) |
PF00905(Transpeptidase) | 5 | VAL A 300GLU A 298ASP A 283ALA A 294PRO A 180 | None | 1.25A | 5hnzB-4mnrA:undetectable | 5hnzB-4mnrA:25.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n17 | TRAP DICARBOXYLATETRANSPORTER, DCTPSUBUNIT (Burkholderiaambifaria) |
PF03480(DctP) | 5 | GLU A 323ASP A 113HIS A 116ALA A 120THR A 234 | None | 1.21A | 5hnzB-4n17A:undetectable | 5hnzB-4n17A:23.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p6b | EST-Y29 (metagenome) |
PF00144(Beta-lactamase) | 5 | ASP A 268ALA A 274PHE A 353THR A 351PRO A 62 | None | 1.25A | 5hnzB-4p6bA:undetectable | 5hnzB-4p6bA:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q2e | PHOSPHATIDATECYTIDYLYLTRANSFERASE (Thermotogamaritima) |
PF01148(CTP_transf_1) | 5 | ASP A 235LEU A 56ALA A 275SER A 278PHE A 141 | MG A 304 ( 3.8A)NoneNoneNoneNone | 1.05A | 5hnzB-4q2eA:undetectable | 5hnzB-4q2eA:22.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wa8 | FLAP ENDONUCLEASE 1 (Methanopyruskandleri) |
PF00752(XPG_N)PF00867(XPG_I) | 5 | ASP A 125GLU A 126LEU A 310HIS A 57ALA A 132 | None | 1.05A | 5hnzB-4wa8A:undetectable | 5hnzB-4wa8A:21.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wis | LIPID SCRAMBLASE ([Nectria]haematococca) |
PF04547(Anoctamin) | 5 | VAL A 500ASP A 499LEU A 565SER A 184THR A 563 | None | 1.05A | 5hnzB-4wisA:undetectable | 5hnzB-4wisA:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yla | AROMATICPRENYLTRANSFERASE (Marinactinosporathermotolerans) |
PF11991(Trp_DMAT) | 5 | LEU A 90HIS A 43ALA A 56THR A 105PRO A 170 | NoneNoneNoneDST A 405 ( 3.8A)None | 1.25A | 5hnzB-4ylaA:undetectable | 5hnzB-4ylaA:22.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ysw | XANTHINEDEHYDROGENASE/OXIDASE (Rattusnorvegicus) |
PF00111(Fer2)PF00941(FAD_binding_5)PF01315(Ald_Xan_dh_C)PF01799(Fer2_2)PF02738(Ald_Xan_dh_C2)PF03450(CO_deh_flav_C) | 5 | GLU A 929SER A 928PHE A1271THR A1300ARG A1305 | None | 1.36A | 5hnzB-4yswA:undetectable | 5hnzB-4yswA:16.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ztx | COBALAMIN-INDEPENDENT METHIONINESYNTHASE (Neurosporacrassa) |
PF01717(Meth_synt_2)PF08267(Meth_synt_1) | 5 | VAL A 161GLU A 210HIS A 68SER A 165PHE A 117 | None | 1.35A | 5hnzB-4ztxA:2.7 | 5hnzB-4ztxA:20.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b7s | CYSTEINE DESULFURASE (Thermococcusonnurineus) |
PF00266(Aminotran_5) | 5 | VAL A 200ALA A 191SER A 194THR A 83PRO A 218 | NoneNoneNoneNoneLLP A 216 ( 4.0A) | 1.38A | 5hnzB-5b7sA:2.1 | 5hnzB-5b7sA:20.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5by3 | BTGH115A (Bacteroidesthetaiotaomicron) |
PF15979(Glyco_hydro_115) | 5 | VAL A 394LEU A 202ALA A 440SER A 407ARG A 207 | None | 1.42A | 5hnzB-5by3A:undetectable | 5hnzB-5by3A:19.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5by3 | BTGH115A (Bacteroidesthetaiotaomicron) |
PF15979(Glyco_hydro_115) | 5 | VAL A 394LEU A 206ALA A 440SER A 407PRO A 411 | None | 1.27A | 5hnzB-5by3A:undetectable | 5hnzB-5by3A:19.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e02 | FRQ-INTERACTING RNAHELICASE (Neurosporacrassa) |
PF00270(DEAD)PF00271(Helicase_C)PF08148(DSHCT)PF13234(rRNA_proc-arch) | 5 | ASP A 351ALA A 325SER A 201THR A 567PRO A 328 | None | 1.15A | 5hnzB-5e02A:undetectable | 5hnzB-5e02A:17.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e7g | IPT/TIGDOMAIN-CONTAININGPROTEIN BACOVA_02650 (Bacteroidesovatus) |
no annotation | 5 | VAL A 248LEU A 315SER A 246THR A 292PRO A 288 | None | 1.29A | 5hnzB-5e7gA:undetectable | 5hnzB-5e7gA:21.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e7h | IPT/TIGDOMAIN-CONTAININGPROTEIN BACOVA_02650 (Bacteroidesovatus) |
PF01833(TIG) | 5 | VAL A 248LEU A 315SER A 246THR A 292PRO A 288 | None | 1.27A | 5hnzB-5e7hA:undetectable | 5hnzB-5e7hA:21.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f7s | GLYCOSIDE HYDROLASEFAMILY 31 (Trueperellapyogenes) |
PF01055(Glyco_hydro_31)PF13802(Gal_mutarotas_2) | 5 | VAL A 176ASP A 186ALA A 216PHE A 228ARG A 191 | None | 1.36A | 5hnzB-5f7sA:undetectable | 5hnzB-5f7sA:19.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fje | COPPER STORAGEPROTEIN 1 (Methylosinustrichosporium) |
no annotation | 5 | VAL A 29ASP A 32ASP A 21HIS A 25ALA A 109 | NoneNoneNoneNoneCU1 A1127 ( 4.2A) | 1.39A | 5hnzB-5fjeA:undetectable | 5hnzB-5fjeA:16.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g37 | 41.9 KDAINSECTICIDAL TOXIN (Lysinibacillussphaericus) |
PF05431(Toxin_10) | 5 | GLU A 296LEU A 266ALA A 339PHE A 264THR A 288 | None | 1.31A | 5hnzB-5g37A:undetectable | 5hnzB-5g37A:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h6b | PUTATIVE SECRETEDLIPASE (Streptomycessp. W007) |
PF01674(Lipase_2) | 5 | VAL A 202ASP A 200GLU A 231LEU A 77PHE A 153 | None | 1.33A | 5hnzB-5h6bA:4.2 | 5hnzB-5h6bA:21.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h9v | RIBONUCLEASE ZC3H12A (Mus musculus) |
PF11977(RNase_Zc3h12a) | 5 | VAL A 139ASP A 226ALA A 233SER A 236PHE A 259 | None | 1.26A | 5hnzB-5h9vA:undetectable | 5hnzB-5h9vA:19.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5iv8 | LPS BIOSYNTHESISPROTEIN (Klebsiellapneumoniae) |
PF04453(OstA_C) | 5 | ASP A 629GLU A 658LEU A 536ALA A 632SER A 656 | None | 1.30A | 5hnzB-5iv8A:undetectable | 5hnzB-5iv8A:21.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kzm | TRYPTOPHAN SYNTHASEBETA CHAIN (Francisellatularensis) |
PF00291(PALP) | 5 | ASP B 382LEU B 120ALA B 84SER B 376THR B 118 | NoneNoneLLP B 86 ( 4.0A)LLP B 86 ( 2.8A)None | 1.29A | 5hnzB-5kzmB:undetectable | 5hnzB-5kzmB:21.37 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5mjs | TUBULIN BETA CHAIN (Schizosaccharomycespombe) |
no annotation | 5 | ASP A 26GLU A 27ASP A 224ALA A 231PRO A 357 | None | 1.19A | 5hnzB-5mjsA:54.3 | 5hnzB-5mjsA:59.22 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5mjs | TUBULIN BETA CHAIN (Schizosaccharomycespombe) |
no annotation | 6 | ASP A 26GLU A 27LEU A 215ASP A 224HIS A 227PRO A 357 | None | 0.95A | 5hnzB-5mjsA:54.3 | 5hnzB-5mjsA:59.22 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5n5n | TUBULIN BETA CHAIN (Homo sapiens) |
no annotation | 7 | VAL B 23ASP B 26GLU B 27HIS B 229ALA B 233SER B 236THR B 276 | None | 1.07A | 5hnzB-5n5nB:54.6 | 5hnzB-5n5nB:97.89 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5n5n | TUBULIN BETA CHAIN (Homo sapiens) |
no annotation | 8 | VAL B 23ASP B 26GLU B 27LEU B 217ASP B 226HIS B 229ALA B 233THR B 276 | None | 1.07A | 5hnzB-5n5nB:54.6 | 5hnzB-5n5nB:97.89 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5n5n | TUBULIN BETA CHAIN (Homo sapiens) |
no annotation | 8 | VAL B 23GLU B 27HIS B 229ALA B 233SER B 236PHE B 272THR B 276PRO B 360 | None | 0.96A | 5hnzB-5n5nB:54.6 | 5hnzB-5n5nB:97.89 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5n5n | TUBULIN BETA CHAIN (Homo sapiens) |
no annotation | 9 | VAL B 23GLU B 27LEU B 217ASP B 226HIS B 229ALA B 233PHE B 272THR B 276PRO B 360 | None | 0.81A | 5hnzB-5n5nB:54.6 | 5hnzB-5n5nB:97.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n9x | ADENYLATION DOMAIN (Streptomycessp.) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 5 | VAL A 111LEU A 60ASP A 69ALA A 72PRO A 123 | None | 1.33A | 5hnzB-5n9xA:undetectable | 5hnzB-5n9xA:21.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nth | PUTATIVEAMINOPEPTIDASE (Leishmaniamajor) |
PF00883(Peptidase_M17) | 5 | VAL A 152GLU A 149LEU A 62ALA A 144SER A 148 | None | 1.32A | 5hnzB-5nthA:3.6 | 5hnzB-5nthA:21.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5oc1 | ARYL-ALCOHOL OXIDASE (Pleurotuseryngii) |
no annotation | 5 | GLU A 179LEU A 314ASP A 448ALA A 455SER A 458 | None | 1.36A | 5hnzB-5oc1A:undetectable | 5hnzB-5oc1A:21.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5oqp | CONDENSIN COMPLEXSUBUNIT 3 (Saccharomycescerevisiae) |
no annotation | 5 | ASP A 433ASP A 371ALA A 428PHE A 362PRO A 383 | None | 1.41A | 5hnzB-5oqpA:undetectable | 5hnzB-5oqpA:18.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v4f | PUTATIVETRANSLATIONALINHIBITOR PROTEIN (Yersinia pestis) |
PF01042(Ribonuc_L-PSP) | 5 | VAL A 23LEU A 66ASP A 75ALA A 108SER A 20 | None | 1.40A | 5hnzB-5v4fA:undetectable | 5hnzB-5v4fA:17.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v6t | PLEXIN-D1 (Mus musculus) |
PF08337(Plexin_cytopl) | 5 | VAL A1835ASP A1757HIS A1760PHE A1741ARG A1484 | None | 1.24A | 5hnzB-5v6tA:undetectable | 5hnzB-5v6tA:22.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vhi | 26S PROTEASOMENON-ATPASEREGULATORY SUBUNIT 2 (Homo sapiens) |
PF00004(AAA) | 5 | GLU f 312LEU f 501ALA f 526SER f 529THR f 499 | None | 1.08A | 5hnzB-5vhif:undetectable | 5hnzB-5vhif:18.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vpq | BETA-LACTAMASE (Paraburkholderiaphymatum) |
PF13354(Beta-lactamase2) | 5 | VAL A 108GLU A 81LEU A 189SER A 130ARG A 192 | None | 1.36A | 5hnzB-5vpqA:undetectable | 5hnzB-5vpqA:20.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vxz | GROWTHARREST-SPECIFICPROTEIN 6 (Homo sapiens) |
PF00054(Laminin_G_1)PF02210(Laminin_G_2) | 5 | ASP A 329GLU A 331ALA A 349THR A 422PRO A 439 | CA A 703 (-2.2A)NoneNoneNoneNone | 1.14A | 5hnzB-5vxzA:undetectable | 5hnzB-5vxzA:23.33 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5w3j | TUBULIN BETA CHAIN (Saccharomycescerevisiae) |
PF00091(Tubulin)PF03953(Tubulin_C) | 7 | VAL B 23ASP B 26GLU B 27LEU B 215ASP B 224THR B 274PRO B 358 | TA1 B 502 (-3.9A)TA1 B 502 (-4.1A)TA1 B 502 (-3.6A)NoneNoneTA1 B 502 (-4.7A)None | 0.52A | 5hnzB-5w3jB:54.2 | 5hnzB-5w3jB:75.61 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5w3j | TUBULIN BETA CHAIN (Saccharomycescerevisiae) |
PF00091(Tubulin)PF03953(Tubulin_C) | 5 | VAL B 23ASP B 26GLU B 27SER B 234PRO B 358 | TA1 B 502 (-3.9A)TA1 B 502 (-4.1A)TA1 B 502 (-3.6A)TA1 B 502 ( 4.9A)None | 0.95A | 5hnzB-5w3jB:54.2 | 5hnzB-5w3jB:75.61 |