SIMILAR PATTERNS OF AMINO ACIDS FOR 5HNZ_B_TA1B902

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bf2 ISOAMYLASE

(Pseudomonas
amyloderamosa) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		5 VAL A 125
LEU A  32
ALA A 122
SER A 257
ARG A  80
 None
 1.41A 5hnzB-1bf2A:
undetectable		 5hnzB-1bf2A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7o CYSTALYSIN

(Treponema
denticola) 		PF00155
(Aminotran_1_2) 		5 ASP A 203
LEU A  17
ASP A  40
SER A 248
PRO A 100
 PPG  A1500 (-3.0A)
PPG  A1500 (-3.5A)
None
PPG  A1500 ( 3.9A)
None
 1.38A 5hnzB-1c7oA:
3.1		 5hnzB-1c7oA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j31 HYPOTHETICAL PROTEIN
PH0642

(Pyrococcus
horikoshii) 		PF00795
(CN_hydrolase) 		5 VAL A 141
ASP A 148
ALA A 167
THR A  87
ARG A 112
 None
 1.42A 5hnzB-1j31A:
undetectable		 5hnzB-1j31A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqo PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Zea mays) 		PF00311
(PEPcase) 		5 VAL A 307
ASP A 306
LEU A 559
ARG A 556
PRO A 301
 None
 1.23A 5hnzB-1jqoA:
undetectable		 5hnzB-1jqoA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kzh PHOSPHOFRUCTOKINASE

(Borreliella
burgdorferi) 		PF00365
(PFK) 		5 LEU A 485
HIS A 213
SER A  59
THR A 483
ARG A  42
 None
 1.14A 5hnzB-1kzhA:
undetectable		 5hnzB-1kzhA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lw7 TRANSCRIPTIONAL
REGULATOR NADR

(Haemophilus
influenzae) 		PF01467
(CTP_transf_like)
PF13521
(AAA_28) 		5 ASP A  99
SER A 106
PHE A 225
ARG A 119
PRO A  69
 None
 1.42A 5hnzB-1lw7A:
3.2		 5hnzB-1lw7A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mg5 ALCOHOL
DEHYDROGENASE

(Drosophila
melanogaster) 		PF00106
(adh_short) 		5 VAL A  65
ASP A  64
LEU A 189
ALA A  13
THR A 188
 NAI  A 850 (-3.5A)
NAI  A 850 (-3.4A)
NAI  A 850 (-3.3A)
NAI  A 850 (-3.2A)
NAI  A 850 ( 4.9A)
 1.35A 5hnzB-1mg5A:
8.7		 5hnzB-1mg5A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n5x XANTHINE
DEHYDROGENASE

(Bos taurus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 GLU A 929
SER A 928
PHE A1271
THR A1301
ARG A1306
 None
 1.42A 5hnzB-1n5xA:
undetectable		 5hnzB-1n5xA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q51 MENB

(Mycobacterium
tuberculosis) 		PF00378
(ECH_1) 		5 ASP A  81
LEU A  34
HIS A  75
ALA A  76
THR A  38
 None
 1.30A 5hnzB-1q51A:
undetectable		 5hnzB-1q51A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rkt PROTEIN YFIR

(Bacillus
subtilis) 		PF00440
(TetR_N) 		5 LEU A 114
SER A  55
PHE A  30
THR A 116
ARG A 124
 UNX  A 423 ( 4.8A)
None
None
None
None
 1.36A 5hnzB-1rktA:
undetectable		 5hnzB-1rktA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2

(Streptomyces
coelicolor) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 VAL B 293
ASP B 292
LEU B 165
ALA B 345
SER B 348
 None
 1.30A 5hnzB-1tqyB:
undetectable		 5hnzB-1tqyB:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txk GLUCANS BIOSYNTHESIS
PROTEIN G

(Escherichia
coli) 		PF04349
(MdoG) 		5 VAL A 474
GLU A 459
ALA A 426
THR A 486
ARG A 489
 None
 1.40A 5hnzB-1txkA:
undetectable		 5hnzB-1txkA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uxi MALATE DEHYDROGENASE

(Chloroflexus
aurantiacus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 VAL A 140
LEU A 303
ASP A 123
ALA A 130
SER A 133
 None
 1.31A 5hnzB-1uxiA:
5.8		 5hnzB-1uxiA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3

(Thermoplasma
acidophilum) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		5 VAL A   3
ASP A  28
GLU A   2
ASP A   7
ALA A 119
 None
 1.29A 5hnzB-1z1wA:
undetectable		 5hnzB-1z1wA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bfr HYPOTHETICAL PROTEIN
AF1521

(Archaeoglobus
fulgidus) 		PF01661
(Macro) 		5 VAL A 168
LEU A 157
PHE A 137
THR A 155
PRO A 123
 None
 1.19A 5hnzB-2bfrA:
undetectable		 5hnzB-2bfrA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2db3 ATP-DEPENDENT RNA
HELICASE VASA

(Drosophila
melanogaster) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 ASP A 399
ASP A 572
HIS A 575
ALA A 433
THR A 580
 MG  A2801 (-3.4A)
None
None
ANP  A2901 ( 3.7A)
None
 1.36A 5hnzB-2db3A:
undetectable		 5hnzB-2db3A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ffu POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 2

(Homo sapiens) 		PF00535
(Glycos_transf_2)
PF00652
(Ricin_B_lectin) 		5 LEU A 173
ALA A 151
SER A 109
THR A 143
ARG A 197
 None
None
None
UDP  A 601 (-3.8A)
None
 1.30A 5hnzB-2ffuA:
undetectable		 5hnzB-2ffuA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gdq YITF

(Bacillus
subtilis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 VAL A 144
GLU A 148
ASP A 170
HIS A 173
ALA A 176
 None
 1.37A 5hnzB-2gdqA:
2.3		 5hnzB-2gdqA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6t UBIQUITIN-CONJUGATIN
G ENZYME E2-LIKE
ISOFORM A

(Homo sapiens) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ASP A 352
LEU A 446
ASP A 449
SER A 458
THR A 444
 None
None
None
None
GOL  A  11 (-3.8A)
 1.34A 5hnzB-2i6tA:
2.2		 5hnzB-2i6tA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix2 DNA POLYMERASE
SLIDING CLAMP B

(Sulfolobus
solfataricus) 		PF00705
(PCNA_N) 		5 VAL A  56
ASP A  55
LEU A  28
SER A 237
PHE A  15
 None
 1.38A 5hnzB-2ix2A:
undetectable		 5hnzB-2ix2A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nz9 BOTULINUM NEUROTOXIN
TYPE A

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		5 VAL A 355
ASP A 352
GLU A 351
LEU A 208
PHE A 196
 None
 1.32A 5hnzB-2nz9A:
undetectable		 5hnzB-2nz9A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ovl PUTATIVE RACEMASE

(Streptomyces
coelicolor) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 VAL A 301
ASP A 303
LEU A  20
HIS A 321
PHE A  31
 None
 1.33A 5hnzB-2ovlA:
undetectable		 5hnzB-2ovlA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qs9 RETINOBLASTOMA-BINDI
NG PROTEIN 9

(Homo sapiens) 		PF06821
(Ser_hydrolase) 		5 VAL A  90
ASP A  66
LEU A 174
ALA A  92
PRO A   4
 None
 1.14A 5hnzB-2qs9A:
3.3		 5hnzB-2qs9A:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wl1 PYRIN

(Homo sapiens) 		PF00622
(SPRY)
PF13765
(PRY) 		5 VAL A 587
LEU A 709
HIS A 739
SER A 728
THR A 707
 None
None
None
None
SCN  A1778 ( 4.7A)
 1.09A 5hnzB-2wl1A:
undetectable		 5hnzB-2wl1A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wp9 SUCCINATE
DEHYDROGENASE
IRON-SULFUR SUBUNIT

(Escherichia
coli) 		PF13085
(Fer2_3)
PF13534
(Fer4_17) 		5 ASP B  32
LEU B  65
ASP B  63
ALA B  38
PHE B   5
 None
None
FES  B 302 (-2.2A)
None
None
 1.18A 5hnzB-2wp9B:
undetectable		 5hnzB-2wp9B:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xd4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Bacillus
subtilis) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		5 VAL A 358
ASP A  35
HIS A 360
ALA A 378
THR A 344
 None
 1.40A 5hnzB-2xd4A:
undetectable		 5hnzB-2xd4A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fvw PUTATIVE
NAD(P)H-DEPENDENT
FMN REDUCTASE

(Streptococcus
mutans) 		PF03358
(FMN_red) 		5 VAL A 143
ASP A 144
ASP A 110
HIS A 141
ALA A 181
 None
 1.33A 5hnzB-3fvwA:
undetectable		 5hnzB-3fvwA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwf CYCLOHEXANONE
MONOOXYGENASE

(Rhodococcus sp.
HI-31) 		PF00743
(FMO-like) 		5 GLU A 252
LEU A  74
ASP A 235
ALA A 241
SER A 244
 None
 1.29A 5hnzB-3gwfA:
undetectable		 5hnzB-3gwfA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwj PUTATIVE
AMINOALDEHYDE
DEHYDROGENASE

(Pisum sativum) 		PF00171
(Aldedh) 		5 VAL A 155
ASP A 232
LEU A 206
ALA A 175
PRO A 151
 None
 1.07A 5hnzB-3iwjA:
undetectable		 5hnzB-3iwjA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwk AMINOALDEHYDE
DEHYDROGENASE

(Pisum sativum) 		PF00171
(Aldedh) 		5 VAL A 155
ASP A 232
LEU A 206
ALA A 175
PRO A 151
 None
 1.10A 5hnzB-3iwkA:
undetectable		 5hnzB-3iwkA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwt 178AA LONG
HYPOTHETICAL
MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
B

(Sulfurisphaera
tokodaii) 		PF00994
(MoCF_biosynth) 		5 VAL A  62
LEU A 106
ALA A  72
SER A  60
ARG A 104
 None
 1.35A 5hnzB-3iwtA:
undetectable		 5hnzB-3iwtA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ju8 SUCCINYLGLUTAMIC
SEMIALDEHYDE
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00171
(Aldedh) 		5 VAL A 140
ASP A 216
LEU A 191
ALA A 160
PRO A 136
 None
 1.13A 5hnzB-3ju8A:
undetectable		 5hnzB-3ju8A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm3 UNCHARACTERIZED
PROTEIN

(Parabacteroides
distasonis) 		PF12979
(DUF3863)
PF12980
(DUF3864) 		5 GLU A 424
LEU A  70
ALA A 143
SER A 181
PRO A 425
 None
 1.42A 5hnzB-3lm3A:
undetectable		 5hnzB-3lm3A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lov PROTOPORPHYRINOGEN
OXIDASE

(Exiguobacterium
sibiricum) 		PF01593
(Amino_oxidase) 		5 ASP A 369
HIS A 307
ALA A 175
SER A 171
THR A 311
 None
 1.23A 5hnzB-3lovA:
undetectable		 5hnzB-3lovA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lsc TRIAZINE HYDROLASE

(Paenarthrobacter
aurescens) 		PF01979
(Amidohydro_1) 		5 LEU A 296
HIS A 238
SER A 161
THR A 324
ARG A 302
 None
ZN  A 458 (-3.2A)
None
None
None
 1.15A 5hnzB-3lscA:
2.9		 5hnzB-3lscA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus scrofa) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		5 VAL A 734
ASP A 733
ALA A 264
SER A 268
THR A 254
 None
 1.07A 5hnzB-3n23A:
2.5		 5hnzB-3n23A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qk8 ENOYL-COA HYDRATASE
ECHA15

(Mycobacterium
marinum) 		PF00378
(ECH_1) 		5 VAL A  33
LEU A 235
HIS A  38
ALA A 117
ARG A  85
 None
None
UNL  A 291 ( 4.0A)
UNL  A 291 ( 3.3A)
None
 1.24A 5hnzB-3qk8A:
undetectable		 5hnzB-3qk8A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9j SEPTUM
SITE-DETERMINING
PROTEIN MIND

(Escherichia
coli) 		PF01656
(CbiA) 		5 VAL A 227
ALA A 233
SER A 216
ARG A 251
PRO A 212
 None
 1.39A 5hnzB-3r9jA:
5.4		 5hnzB-3r9jA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rrv ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacterium
avium) 		PF00378
(ECH_1) 		5 VAL A  30
ASP A  68
ASP A  88
SER A  64
ARG A  82
 None
 1.41A 5hnzB-3rrvA:
undetectable		 5hnzB-3rrvA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5s MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Sorangium
cellulosum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 VAL A 236
GLU A 235
ASP A 194
ALA A 204
ARG A 227
 None
 1.41A 5hnzB-3s5sA:
3.1		 5hnzB-3s5sA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sgz HYDROXYACID OXIDASE
2

(Rattus
norvegicus) 		PF01070
(FMN_dh) 		5 GLU A  88
LEU A 161
ASP A 167
SER A 109
THR A 158
 None
HO6  A 402 ( 4.5A)
None
None
HO6  A 402 ( 4.6A)
 1.35A 5hnzB-3sgzA:
undetectable		 5hnzB-3sgzA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos taurus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 GLU C 929
SER C 928
PHE C1271
THR C1301
ARG C1306
 None
 1.30A 5hnzB-3sr6C:
undetectable		 5hnzB-3sr6C:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v34 RIBONUCLEASE ZC3H12A

(Homo sapiens) 		PF11977
(RNase_Zc3h12a) 		5 VAL A 139
ASP A 226
ALA A 233
SER A 236
PHE A 259
 None
MG  A   1 (-2.8A)
None
None
None
 1.27A 5hnzB-3v34A:
undetectable		 5hnzB-3v34A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vc7 PUTATIVE
OXIDOREDUCTASE

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		5 VAL A 134
ALA A 229
SER A 132
PHE A 230
ARG A  25
 None
 1.06A 5hnzB-3vc7A:
7.5		 5hnzB-3vc7A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23

(Clostridium
botulinum;
Homo sapiens) 		PF01742
(Peptidase_M27)
PF07952
(Toxin_trans) 		5 VAL A 355
ASP A 352
GLU A 351
LEU A 208
PHE A 196
 None
 1.32A 5hnzB-3zusA:
undetectable		 5hnzB-3zusA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zzu ELONGATION FACTOR G

(Staphylococcus
aureus) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF14492
(EFG_II) 		5 VAL A 630
ASP A 631
LEU A 658
ASP A 622
THR A 667
 None
 1.28A 5hnzB-3zzuA:
undetectable		 5hnzB-3zzuA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0m BETAINE ALDEHYDE
DEHYDROGENASE,
CHLOROPLASTIC

(Spinacia
oleracea) 		PF00171
(Aldedh) 		5 VAL A 152
ASP A 229
LEU A 203
ALA A 172
PRO A 148
 None
 1.00A 5hnzB-4a0mA:
undetectable		 5hnzB-4a0mA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bgf ARYLAMINE
N-ACETYLTRANSFERASE
NAT

(Mycobacterium
tuberculosis) 		PF00797
(Acetyltransf_2) 		5 LEU A  52
ASP A  50
ALA A 196
SER A 202
PRO A 107
 None
 1.33A 5hnzB-4bgfA:
undetectable		 5hnzB-4bgfA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4blq P4

(Pseudomonas
phage phi8) 		PF11602
(NTPase_P4) 		5 VAL A  21
LEU A 173
ALA A 156
THR A 214
ARG A 174
 None
 1.03A 5hnzB-4blqA:
undetectable		 5hnzB-4blqA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bwy P4

(Pseudomonas
phage phi8) 		PF11602
(NTPase_P4) 		5 VAL A  21
LEU A 173
ALA A 156
THR A 214
ARG A 174
 None
 1.04A 5hnzB-4bwyA:
undetectable		 5hnzB-4bwyA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fmc RORF2

(Escherichia
coli) 		PF06872
(EspG) 		5 VAL A 340
LEU A 234
ALA A 290
SER A 342
PHE A 291
 None
 1.28A 5hnzB-4fmcA:
undetectable		 5hnzB-4fmcA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g2b SECRETED EFFECTOR
PROTEIN SSEI

(Salmonella
enterica) 		PF15645
(Tox-PLDMTX) 		5 ALA A 234
SER A 233
PHE A 237
THR A 264
ARG A 261
 None
 1.27A 5hnzB-4g2bA:
undetectable		 5hnzB-4g2bA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8p AMINOALDEHYDE
DEHYDROGENASE 1

(Zea mays) 		PF00171
(Aldedh) 		5 VAL A 157
ASP A 234
ALA A 177
ARG A  62
PRO A 153
 None
 1.40A 5hnzB-4i8pA:
undetectable		 5hnzB-4i8pA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8p AMINOALDEHYDE
DEHYDROGENASE 1

(Zea mays) 		PF00171
(Aldedh) 		5 VAL A 157
ASP A 234
LEU A 208
ALA A 177
PRO A 153
 None
 1.03A 5hnzB-4i8pA:
undetectable		 5hnzB-4i8pA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8q PUTATIVE BETAINE
ALDEHYDE
DEHYROGENASE

(Solanum
lycopersicum) 		PF00171
(Aldedh) 		5 VAL A 155
ASP A 232
LEU A 206
ALA A 175
PRO A 151
 None
 0.97A 5hnzB-4i8qA:
undetectable		 5hnzB-4i8qA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A 338
GLU A 334
LEU A 433
ASP A 376
ARG A 366
 None
 1.39A 5hnzB-4idtA:
undetectable		 5hnzB-4idtA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iq4 NON-HAEM
BROMOPEROXIDASE
BPO-A2, MATRIX
PROTEIN 1

(Influenza A
virus;
Kitasatospora
aureofaciens) 		PF00561
(Abhydrolase_1)
PF00598
(Flu_M1) 		5 VAL A 104
LEU A  46
ALA A 120
PHE A 274
ARG A  52
 None
 0.89A 5hnzB-4iq4A:
3.9		 5hnzB-4iq4A:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jqp 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE

(Paraburkholderia
phymatum) 		PF04166
(PdxA) 		5 VAL A 323
GLU A  31
ASP A 310
HIS A 311
ALA A 314
 None
 1.33A 5hnzB-4jqpA:
undetectable		 5hnzB-4jqpA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg9 F-BOX-LIKE/WD
REPEAT-CONTAINING
PROTEIN TBL1XR1

(Homo sapiens) 		PF00400
(WD40) 		5 VAL A 352
ASP A 369
LEU A 415
ALA A 354
ARG A 425
 None
 1.32A 5hnzB-4lg9A:
undetectable		 5hnzB-4lg9A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lsd FIBRONECTIN TYPE III
DOMAIN-CONTAINING
PROTEIN 5

(Homo sapiens) 		PF00041
(fn3) 		5 VAL A  59
ASP A  56
GLU A  55
ALA A 104
ARG A  40
 None
 1.08A 5hnzB-4lsdA:
undetectable		 5hnzB-4lsdA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m8n PLEXINC1
INTRACELLULAR REGION

(Danio rerio) 		PF08337
(Plexin_cytopl) 		5 VAL A1067
ASP A 988
HIS A 991
PHE A 972
ARG A 711
 None
None
None
None
GDP  E 201 ( 2.9A)
 1.34A 5hnzB-4m8nA:
undetectable		 5hnzB-4m8nA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE

(Eggerthella
lenta) 		PF00905
(Transpeptidase) 		5 VAL A 300
GLU A 298
ASP A 283
ALA A 294
PRO A 180
 None
 1.25A 5hnzB-4mnrA:
undetectable		 5hnzB-4mnrA:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n17 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Burkholderia
ambifaria) 		PF03480
(DctP) 		5 GLU A 323
ASP A 113
HIS A 116
ALA A 120
THR A 234
 None
 1.21A 5hnzB-4n17A:
undetectable		 5hnzB-4n17A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p6b EST-Y29

(metagenome) 		PF00144
(Beta-lactamase) 		5 ASP A 268
ALA A 274
PHE A 353
THR A 351
PRO A  62
 None
 1.25A 5hnzB-4p6bA:
undetectable		 5hnzB-4p6bA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2e PHOSPHATIDATE
CYTIDYLYLTRANSFERASE

(Thermotoga
maritima) 		PF01148
(CTP_transf_1) 		5 ASP A 235
LEU A  56
ALA A 275
SER A 278
PHE A 141
 MG  A 304 ( 3.8A)
None
None
None
None
 1.05A 5hnzB-4q2eA:
undetectable		 5hnzB-4q2eA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wa8 FLAP ENDONUCLEASE 1

(Methanopyrus
kandleri) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		5 ASP A 125
GLU A 126
LEU A 310
HIS A  57
ALA A 132
 None
 1.05A 5hnzB-4wa8A:
undetectable		 5hnzB-4wa8A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wis LIPID SCRAMBLASE

([Nectria]
haematococca) 		PF04547
(Anoctamin) 		5 VAL A 500
ASP A 499
LEU A 565
SER A 184
THR A 563
 None
 1.05A 5hnzB-4wisA:
undetectable		 5hnzB-4wisA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yla AROMATIC
PRENYLTRANSFERASE

(Marinactinospora
thermotolerans) 		PF11991
(Trp_DMAT) 		5 LEU A  90
HIS A  43
ALA A  56
THR A 105
PRO A 170
 None
None
None
DST  A 405 ( 3.8A)
None
 1.25A 5hnzB-4ylaA:
undetectable		 5hnzB-4ylaA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysw XANTHINE
DEHYDROGENASE/OXIDAS
E

(Rattus
norvegicus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 GLU A 929
SER A 928
PHE A1271
THR A1300
ARG A1305
 None
 1.36A 5hnzB-4yswA:
undetectable		 5hnzB-4yswA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE

(Neurospora
crassa) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		5 VAL A 161
GLU A 210
HIS A  68
SER A 165
PHE A 117
 None
 1.35A 5hnzB-4ztxA:
2.7		 5hnzB-4ztxA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7s CYSTEINE DESULFURASE

(Thermococcus
onnurineus) 		PF00266
(Aminotran_5) 		5 VAL A 200
ALA A 191
SER A 194
THR A  83
PRO A 218
 None
None
None
None
LLP  A 216 ( 4.0A)
 1.38A 5hnzB-5b7sA:
2.1		 5hnzB-5b7sA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5by3 BTGH115A

(Bacteroides
thetaiotaomicron) 		PF15979
(Glyco_hydro_115) 		5 VAL A 394
LEU A 202
ALA A 440
SER A 407
ARG A 207
 None
 1.42A 5hnzB-5by3A:
undetectable		 5hnzB-5by3A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5by3 BTGH115A

(Bacteroides
thetaiotaomicron) 		PF15979
(Glyco_hydro_115) 		5 VAL A 394
LEU A 206
ALA A 440
SER A 407
PRO A 411
 None
 1.27A 5hnzB-5by3A:
undetectable		 5hnzB-5by3A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e02 FRQ-INTERACTING RNA
HELICASE

(Neurospora
crassa) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch) 		5 ASP A 351
ALA A 325
SER A 201
THR A 567
PRO A 328
 None
 1.15A 5hnzB-5e02A:
undetectable		 5hnzB-5e02A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7g IPT/TIG
DOMAIN-CONTAINING
PROTEIN BACOVA_02650

(Bacteroides
ovatus) 		no annotation 5 VAL A 248
LEU A 315
SER A 246
THR A 292
PRO A 288
 None
 1.29A 5hnzB-5e7gA:
undetectable		 5hnzB-5e7gA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7h IPT/TIG
DOMAIN-CONTAINING
PROTEIN BACOVA_02650

(Bacteroides
ovatus) 		PF01833
(TIG) 		5 VAL A 248
LEU A 315
SER A 246
THR A 292
PRO A 288
 None
 1.27A 5hnzB-5e7hA:
undetectable		 5hnzB-5e7hA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7s GLYCOSIDE HYDROLASE
FAMILY 31

(Trueperella
pyogenes) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		5 VAL A 176
ASP A 186
ALA A 216
PHE A 228
ARG A 191
 None
 1.36A 5hnzB-5f7sA:
undetectable		 5hnzB-5f7sA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fje COPPER STORAGE
PROTEIN 1

(Methylosinus
trichosporium) 		no annotation 5 VAL A  29
ASP A  32
ASP A  21
HIS A  25
ALA A 109
 None
None
None
None
CU1  A1127 ( 4.2A)
 1.39A 5hnzB-5fjeA:
undetectable		 5hnzB-5fjeA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g37 41.9 KDA
INSECTICIDAL TOXIN

(Lysinibacillus
sphaericus) 		PF05431
(Toxin_10) 		5 GLU A 296
LEU A 266
ALA A 339
PHE A 264
THR A 288
 None
 1.31A 5hnzB-5g37A:
undetectable		 5hnzB-5g37A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h6b PUTATIVE SECRETED
LIPASE

(Streptomyces
sp. W007) 		PF01674
(Lipase_2) 		5 VAL A 202
ASP A 200
GLU A 231
LEU A  77
PHE A 153
 None
 1.33A 5hnzB-5h6bA:
4.2		 5hnzB-5h6bA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9v RIBONUCLEASE ZC3H12A

(Mus musculus) 		PF11977
(RNase_Zc3h12a) 		5 VAL A 139
ASP A 226
ALA A 233
SER A 236
PHE A 259
 None
 1.26A 5hnzB-5h9vA:
undetectable		 5hnzB-5h9vA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iv8 LPS BIOSYNTHESIS
PROTEIN

(Klebsiella
pneumoniae) 		PF04453
(OstA_C) 		5 ASP A 629
GLU A 658
LEU A 536
ALA A 632
SER A 656
 None
 1.30A 5hnzB-5iv8A:
undetectable		 5hnzB-5iv8A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzm TRYPTOPHAN SYNTHASE
BETA CHAIN

(Francisella
tularensis) 		PF00291
(PALP) 		5 ASP B 382
LEU B 120
ALA B  84
SER B 376
THR B 118
 None
None
LLP  B  86 ( 4.0A)
LLP  B  86 ( 2.8A)
None
 1.29A 5hnzB-5kzmB:
undetectable		 5hnzB-5kzmB:
21.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mjs TUBULIN BETA CHAIN

(Schizosaccharomyces
pombe) 		no annotation 5 ASP A  26
GLU A  27
ASP A 224
ALA A 231
PRO A 357
 None
 1.19A 5hnzB-5mjsA:
54.3		 5hnzB-5mjsA:
59.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mjs TUBULIN BETA CHAIN

(Schizosaccharomyces
pombe) 		no annotation 6 ASP A  26
GLU A  27
LEU A 215
ASP A 224
HIS A 227
PRO A 357
 None
 0.95A 5hnzB-5mjsA:
54.3		 5hnzB-5mjsA:
59.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 7 VAL B  23
ASP B  26
GLU B  27
HIS B 229
ALA B 233
SER B 236
THR B 276
 None
 1.07A 5hnzB-5n5nB:
54.6		 5hnzB-5n5nB:
97.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 8 VAL B  23
ASP B  26
GLU B  27
LEU B 217
ASP B 226
HIS B 229
ALA B 233
THR B 276
 None
 1.07A 5hnzB-5n5nB:
54.6		 5hnzB-5n5nB:
97.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 8 VAL B  23
GLU B  27
HIS B 229
ALA B 233
SER B 236
PHE B 272
THR B 276
PRO B 360
 None
 0.96A 5hnzB-5n5nB:
54.6		 5hnzB-5n5nB:
97.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 9 VAL B  23
GLU B  27
LEU B 217
ASP B 226
HIS B 229
ALA B 233
PHE B 272
THR B 276
PRO B 360
 None
 0.81A 5hnzB-5n5nB:
54.6		 5hnzB-5n5nB:
97.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n9x ADENYLATION DOMAIN

(Streptomyces
sp.) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 VAL A 111
LEU A  60
ASP A  69
ALA A  72
PRO A 123
 None
 1.33A 5hnzB-5n9xA:
undetectable		 5hnzB-5n9xA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nth PUTATIVE
AMINOPEPTIDASE

(Leishmania
major) 		PF00883
(Peptidase_M17) 		5 VAL A 152
GLU A 149
LEU A  62
ALA A 144
SER A 148
 None
 1.32A 5hnzB-5nthA:
3.6		 5hnzB-5nthA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oc1 ARYL-ALCOHOL OXIDASE

(Pleurotus
eryngii) 		no annotation 5 GLU A 179
LEU A 314
ASP A 448
ALA A 455
SER A 458
 None
 1.36A 5hnzB-5oc1A:
undetectable		 5hnzB-5oc1A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oqp CONDENSIN COMPLEX
SUBUNIT 3

(Saccharomyces
cerevisiae) 		no annotation 5 ASP A 433
ASP A 371
ALA A 428
PHE A 362
PRO A 383
 None
 1.41A 5hnzB-5oqpA:
undetectable		 5hnzB-5oqpA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v4f PUTATIVE
TRANSLATIONAL
INHIBITOR PROTEIN

(Yersinia pestis) 		PF01042
(Ribonuc_L-PSP) 		5 VAL A  23
LEU A  66
ASP A  75
ALA A 108
SER A  20
 None
 1.40A 5hnzB-5v4fA:
undetectable		 5hnzB-5v4fA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v6t PLEXIN-D1

(Mus musculus) 		PF08337
(Plexin_cytopl) 		5 VAL A1835
ASP A1757
HIS A1760
PHE A1741
ARG A1484
 None
 1.24A 5hnzB-5v6tA:
undetectable		 5hnzB-5v6tA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vhi 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 2

(Homo sapiens) 		PF00004
(AAA) 		5 GLU f 312
LEU f 501
ALA f 526
SER f 529
THR f 499
 None
 1.08A 5hnzB-5vhif:
undetectable		 5hnzB-5vhif:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vpq BETA-LACTAMASE

(Paraburkholderia
phymatum) 		PF13354
(Beta-lactamase2) 		5 VAL A 108
GLU A  81
LEU A 189
SER A 130
ARG A 192
 None
 1.36A 5hnzB-5vpqA:
undetectable		 5hnzB-5vpqA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vxz GROWTH
ARREST-SPECIFIC
PROTEIN 6

(Homo sapiens) 		PF00054
(Laminin_G_1)
PF02210
(Laminin_G_2) 		5 ASP A 329
GLU A 331
ALA A 349
THR A 422
PRO A 439
 CA  A 703 (-2.2A)
None
None
None
None
 1.14A 5hnzB-5vxzA:
undetectable		 5hnzB-5vxzA:
23.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w3j TUBULIN BETA CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		7 VAL B  23
ASP B  26
GLU B  27
LEU B 215
ASP B 224
THR B 274
PRO B 358
 TA1  B 502 (-3.9A)
TA1  B 502 (-4.1A)
TA1  B 502 (-3.6A)
None
None
TA1  B 502 (-4.7A)
None
 0.52A 5hnzB-5w3jB:
54.2		 5hnzB-5w3jB:
75.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w3j TUBULIN BETA CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		5 VAL B  23
ASP B  26
GLU B  27
SER B 234
PRO B 358
 TA1  B 502 (-3.9A)
TA1  B 502 (-4.1A)
TA1  B 502 (-3.6A)
TA1  B 502 ( 4.9A)
None
 0.95A 5hnzB-5w3jB:
54.2		 5hnzB-5w3jB:
75.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aor ALDEHYDE FERREDOXIN
OXIDOREDUCTASE

(Pyrococcus
furiosus) 		PF01314
(AFOR_C)
PF02730
(AFOR_N) 		3 LEU A 510
LEU A 493
ARG A 222
 None
 0.61A 5hnzB-1aorA:
undetectable		 5hnzB-1aorA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxc XYLOSE ISOMERASE

(Thermus
caldophilus) 		PF01261
(AP_endonuc_2) 		3 LEU A 128
LEU A  78
ARG A   9
 None
 0.33A 5hnzB-1bxcA:
undetectable		 5hnzB-1bxcA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cja PROTEIN
(ACTIN-FRAGMIN
KINASE)

(Physarum
polycephalum) 		PF09192
(Act-Frag_cataly) 		3 LEU A 170
LEU A 190
ARG A 224
 None
 0.63A 5hnzB-1cjaA:
undetectable		 5hnzB-1cjaA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cnv CONCANAVALIN B

(Canavalia
ensiformis) 		PF00704
(Glyco_hydro_18) 		3 LEU A 118
LEU A  81
ARG A  44
 None
 0.66A 5hnzB-1cnvA:
undetectable		 5hnzB-1cnvA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1t LYSYL-TRNA
SYNTHETASE, HEAT
INDUCIBLE

(Escherichia
coli) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		3 LEU A 429
LEU A 464
ARG A 236
 None
 0.58A 5hnzB-1e1tA:
undetectable		 5hnzB-1e1tA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1evs ONCOSTATIN M

(Homo sapiens) 		PF01291
(LIF_OSM) 		3 LEU A  30
LEU A  85
ARG A  52
 None
 0.49A 5hnzB-1evsA:
undetectable		 5hnzB-1evsA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ex0 COAGULATION FACTOR
XIII A CHAIN

(Homo sapiens) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		3 LEU A 598
LEU A 529
ARG A 661
 None
 0.64A 5hnzB-1ex0A:
undetectable		 5hnzB-1ex0A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE,
GLYCOSOMAL

(Trypanosoma
brucei) 		PF00274
(Glycolytic) 		3 LEU A  87
LEU A  73
ARG A 313
 None
 0.61A 5hnzB-1f2jA:
undetectable		 5hnzB-1f2jA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ff9 SACCHAROPINE
REDUCTASE

(Magnaporthe
grisea) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		3 LEU A 360
LEU A 125
ARG A 355
 None
 0.59A 5hnzB-1ff9A:
4.5		 5hnzB-1ff9A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gxl CHROMOSOME
SEGREGATION SMC
PROTEIN

(Thermotoga
maritima) 		PF06470
(SMC_hinge) 		3 LEU A 613
LEU A 571
ARG A 650
 None
 0.66A 5hnzB-1gxlA:
undetectable		 5hnzB-1gxlA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyt CYTOSOL
AMINOPEPTIDASE

(Escherichia
coli) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		3 LEU A 388
LEU A 420
ARG A 443
 None
 0.59A 5hnzB-1gytA:
undetectable		 5hnzB-1gytA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h0h FORMATE
DEHYDROGENASE
SUBUNIT ALPHA

(Desulfovibrio
gigas) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		3 LEU A 608
LEU A  92
ARG A 103
 None
 0.54A 5hnzB-1h0hA:
1.8		 5hnzB-1h0hA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1im8 YECO

(Haemophilus
influenzae) 		PF13649
(Methyltransf_25) 		3 LEU A 145
LEU A 130
ARG A 166
 None
 0.65A 5hnzB-1im8A:
3.1		 5hnzB-1im8A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1inp INOSITOL
POLYPHOSPHATE
1-PHOSPHATASE

(Bos taurus) 		PF00459
(Inositol_P) 		3 LEU A  56
LEU A  96
ARG A  10
 None
 0.63A 5hnzB-1inpA:
undetectable		 5hnzB-1inpA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itk CATALASE-PEROXIDASE

(Haloarcula
marismortui) 		PF00141
(peroxidase) 		3 LEU A 687
LEU A 651
ARG A 694
 None
 0.66A 5hnzB-1itkA:
undetectable		 5hnzB-1itkA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itu RENAL DIPEPTIDASE

(Homo sapiens) 		PF01244
(Peptidase_M19) 		3 LEU A 208
LEU A 196
ARG A 182
 None
 0.64A 5hnzB-1ituA:
undetectable		 5hnzB-1ituA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iuf CENTROMERE ABP1
PROTEIN

(Schizosaccharomyces
pombe) 		PF03221
(HTH_Tnp_Tc5) 		3 LEU A  54
LEU A  33
ARG A   7
 None
 0.50A 5hnzB-1iufA:
undetectable		 5hnzB-1iufA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ixr RUVB

(Thermus
thermophilus) 		PF05491
(RuvB_C)
PF05496
(RuvB_N) 		3 LEU C  54
LEU C 165
ARG C 209
 None
 0.60A 5hnzB-1ixrC:
undetectable		 5hnzB-1ixrC:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jgs MULTIPLE ANTIBIOTIC
RESISTANCE PROTEIN
MARR

(Escherichia
coli) 		PF01047
(MarR) 		3 LEU A  60
LEU A  75
ARG A  94
 None
SAL  A 256 ( 4.6A)
None
 0.62A 5hnzB-1jgsA:
undetectable		 5hnzB-1jgsA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqo PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Zea mays) 		PF00311
(PEPcase) 		3 LEU A 318
LEU A 450
ARG A 388
 None
 0.64A 5hnzB-1jqoA:
2.0		 5hnzB-1jqoA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqo PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Zea mays) 		PF00311
(PEPcase) 		3 LEU A 544
LEU A 581
ARG A 456
 None
 0.45A 5hnzB-1jqoA:
2.0		 5hnzB-1jqoA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m5y SURVIVAL PROTEIN
SURA

(Escherichia
coli) 		PF00639
(Rotamase)
PF09312
(SurA_N)
PF13616
(Rotamase_3) 		3 LEU A 226
LEU A  66
ARG A  57
 None
 0.47A 5hnzB-1m5yA:
undetectable		 5hnzB-1m5yA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mlz 7,8-DIAMINO-PELARGON
IC ACID
AMINOTRANSFERASE

(Escherichia
coli) 		PF00202
(Aminotran_3) 		3 LEU A 399
LEU A 347
ARG A 221
 None
 0.57A 5hnzB-1mlzA:
undetectable		 5hnzB-1mlzA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n97 CYP175A1

(Thermus
thermophilus) 		PF00067
(p450) 		3 LEU A 219
LEU A 190
ARG A  77
 None
 0.48A 5hnzB-1n97A:
undetectable		 5hnzB-1n97A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o1y CONSERVED
HYPOTHETICAL PROTEIN
TM1158

(Thermotoga
maritima) 		PF00117
(GATase) 		3 LEU A 220
LEU A 170
ARG A 131
 None
None
SO4  A 404 (-3.1A)
 0.53A 5hnzB-1o1yA:
undetectable		 5hnzB-1o1yA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o99 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Geobacillus
stearothermophilus) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		3 LEU A 487
LEU A   8
ARG A 348
 None
 0.65A 5hnzB-1o99A:
1.7		 5hnzB-1o99A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o9r AGROBACTERIUM
TUMEFACIENS DPS

(Agrobacterium
tumefaciens) 		PF00210
(Ferritin) 		3 LEU A  62
LEU A 147
ARG A  72
 None
 0.56A 5hnzB-1o9rA:
undetectable		 5hnzB-1o9rA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oyj GLUTATHIONE
S-TRANSFERASE

(Oryza sativa) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		3 LEU A 115
LEU A 144
ARG A 105
 None
 0.62A 5hnzB-1oyjA:
undetectable		 5hnzB-1oyjA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q15 CARA

(Pectobacterium
carotovorum) 		PF00733
(Asn_synthase)
PF09147
(DUF1933) 		3 LEU A  55
LEU A  59
ARG A  91
 None
 0.65A 5hnzB-1q15A:
undetectable		 5hnzB-1q15A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Escherichia
coli) 		PF00311
(PEPcase) 		3 LEU A 484
LEU A 521
ARG A 396
 None
 0.60A 5hnzB-1qb4A:
2.4		 5hnzB-1qb4A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qw1 DIPHTHERIA TOXIN
REPRESSOR

(Corynebacterium
diphtheriae) 		no annotation 3 LEU A 120
LEU A 217
ARG A 125
 None
 0.53A 5hnzB-1qw1A:
undetectable		 5hnzB-1qw1A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qzm ATP-DEPENDENT
PROTEASE LA

(Escherichia
coli) 		no annotation 3 LEU A 551
LEU A 521
ARG A 504
 None
 0.58A 5hnzB-1qzmA:
undetectable		 5hnzB-1qzmA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qzz ACLACINOMYCIN-10-HYD
ROXYLASE

(Streptomyces
purpurascens) 		PF00891
(Methyltransf_2) 		3 LEU A 202
LEU A 230
ARG A 184
 None
 0.65A 5hnzB-1qzzA:
2.5		 5hnzB-1qzzA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r9j TRANSKETOLASE

(Leishmania
mexicana) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		3 LEU A 370
LEU A 505
ARG A 332
 None
 0.66A 5hnzB-1r9jA:
undetectable		 5hnzB-1r9jA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rpn GDP-MANNOSE
4,6-DEHYDRATASE

(Pseudomonas
aeruginosa) 		PF16363
(GDP_Man_Dehyd) 		3 LEU A  32
LEU A 108
ARG A   3
 None
 0.61A 5hnzB-1rpnA:
7.3		 5hnzB-1rpnA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ser PROTEIN (SERYL-TRNA
SYNTHETASE
(E.C.6.1.1.11))

(Thermus
thermophilus) 		PF00587
(tRNA-synt_2b)
PF02403
(Seryl_tRNA_N) 		3 LEU A   7
LEU A  98
ARG A 363
 None
 0.60A 5hnzB-1serA:
undetectable		 5hnzB-1serA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sk7 HYPOTHETICAL PROTEIN
PA-HO

(Pseudomonas
aeruginosa) 		PF01126
(Heme_oxygenase) 		3 LEU A 109
LEU A  68
ARG A 188
 None
 0.63A 5hnzB-1sk7A:
undetectable		 5hnzB-1sk7A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sma MALTOGENIC AMYLASE

(Thermus sp.
IM6501) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C) 		3 LEU A 228
LEU A 195
ARG A 200
 None
 0.65A 5hnzB-1smaA:
undetectable		 5hnzB-1smaA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sq8 DH434

(Escherichia
virus Lambda) 		PF01381
(HTH_3) 		3 LEU A  60
LEU A  45
ARG A   7
 None
 0.58A 5hnzB-1sq8A:
undetectable		 5hnzB-1sq8A:
8.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 40 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF13177
(DNA_pol3_delta2) 		3 LEU E 113
LEU E  94
ARG E 134
 None
 0.58A 5hnzB-1sxjE:
undetectable		 5hnzB-1sxjE:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tjr BX1

(Zea mays) 		PF00290
(Trp_syntA) 		3 LEU A 135
LEU A 170
ARG A  87
 None
 0.64A 5hnzB-1tjrA:
undetectable		 5hnzB-1tjrA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u10 PENICILLIN-INSENSITI
VE MUREIN
ENDOPEPTIDASE

(Escherichia
coli) 		PF03411
(Peptidase_M74) 		3 LEU A 163
LEU A  81
ARG A 175
 None
 0.66A 5hnzB-1u10A:
undetectable		 5hnzB-1u10A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6g TIP120 PROTEIN

(Homo sapiens) 		PF08623
(TIP120) 		3 LEU C 181
LEU C 199
ARG C 228
 None
 0.47A 5hnzB-1u6gC:
2.3		 5hnzB-1u6gC:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6g TIP120 PROTEIN

(Homo sapiens) 		PF08623
(TIP120) 		3 LEU C 461
LEU C 469
ARG C 451
 None
 0.56A 5hnzB-1u6gC:
2.3		 5hnzB-1u6gC:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uj2 URIDINE-CYTIDINE
KINASE 2

(Homo sapiens) 		PF00485
(PRK) 		3 LEU A  44
LEU A 229
ARG A  52
 None
 0.64A 5hnzB-1uj2A:
undetectable		 5hnzB-1uj2A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1unl CYCLIN-DEPENDENT
KINASE 5 ACTIVATOR 1

(Homo sapiens) 		PF03261
(CDK5_activator) 		3 LEU D 155
LEU D 226
ARG D 183
 None
 0.56A 5hnzB-1unlD:
undetectable		 5hnzB-1unlD:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1urj MAJOR DNA-BINDING
PROTEIN

(Human
alphaherpesvirus
1) 		PF00747
(Viral_DNA_bp) 		3 LEU A  37
LEU A  55
ARG A 101
 None
 0.55A 5hnzB-1urjA:
undetectable		 5hnzB-1urjA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1urj MAJOR DNA-BINDING
PROTEIN

(Human
alphaherpesvirus
1) 		PF00747
(Viral_DNA_bp) 		3 LEU A 469
LEU A 451
ARG A  40
 None
 0.62A 5hnzB-1urjA:
undetectable		 5hnzB-1urjA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w18 LEVANSUCRASE

(Gluconacetobacter
diazotrophicus) 		PF02435
(Glyco_hydro_68) 		3 LEU A 111
LEU A 454
ARG A 514
 None
 0.61A 5hnzB-1w18A:
undetectable		 5hnzB-1w18A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8j MYOSIN VA

(Gallus gallus) 		PF00063
(Myosin_head) 		3 LEU A 265
LEU A 333
ARG A 219
 None
 0.58A 5hnzB-1w8jA:
undetectable		 5hnzB-1w8jA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wwv CONNECTOR ENHANCER
OF KINASE SUPPRESSOR
OF RAS 1

(Homo sapiens) 		PF00536
(SAM_1) 		3 LEU A  68
LEU A  53
ARG A  24
 None
 0.56A 5hnzB-1wwvA:
undetectable		 5hnzB-1wwvA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wz8 ENOYL-COA HYDRATASE

(Thermus
thermophilus) 		PF00378
(ECH_1) 		3 LEU A  42
LEU A  12
ARG A 105
 None
 0.66A 5hnzB-1wz8A:
undetectable		 5hnzB-1wz8A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xls ORPHAN NUCLEAR
RECEPTOR NR1I3
RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens;
Mus musculus) 		PF00104
(Hormone_recep) 		3 LEU E 322
LEU E 302
ARG A 414
 None
 0.61A 5hnzB-1xlsE:
undetectable		 5hnzB-1xlsE:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y4c MALTOSE BINDING
PROTEIN FUSED WITH
DESIGNED HELICAL
PROTEIN

(Escherichia
coli) 		PF13416
(SBP_bac_8) 		3 LEU A 552
LEU A 611
ARG A 585
 None
 0.66A 5hnzB-1y4cA:
undetectable		 5hnzB-1y4cA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygp YEAST GLYCOGEN
PHOSPHORYLASE

(Saccharomyces
cerevisiae) 		PF00343
(Phosphorylase) 		3 LEU A 293
LEU A 344
ARG A 220
 None
 0.51A 5hnzB-1ygpA:
0.4		 5hnzB-1ygpA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yrg GTPASE-ACTIVATING
PROTEIN RNA1_SCHPO

(Schizosaccharomyces
pombe) 		no annotation 3 LEU A 129
LEU A 118
ARG A 162
 None
 0.56A 5hnzB-1yrgA:
undetectable		 5hnzB-1yrgA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6t APOPTOTIC PROTEASE
ACTIVATING FACTOR 1

(Homo sapiens) 		PF00619
(CARD)
PF00931
(NB-ARC) 		3 LEU A  16
LEU A  75
ARG A  44
 None
 0.56A 5hnzB-1z6tA:
undetectable		 5hnzB-1z6tA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zcz BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Thermotoga
maritima) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		3 LEU A   8
LEU A  18
ARG A  79
 None
 0.64A 5hnzB-1zczA:
undetectable		 5hnzB-1zczA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zoq INTERFERON
REGULATORY FACTOR 3

(Homo sapiens) 		PF10401
(IRF-3) 		3 LEU A 322
LEU A 372
ARG A 338
 None
 0.60A 5hnzB-1zoqA:
undetectable		 5hnzB-1zoqA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zup HYPOTHETICAL PROTEIN
TM1739

(Thermotoga
maritima) 		PF09376
(NurA) 		3 LEU A 257
LEU A 233
ARG A  37
 None
 0.49A 5hnzB-1zupA:
undetectable		 5hnzB-1zupA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aj4 GALACTOKINASE

(Saccharomyces
cerevisiae) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		3 LEU A 402
LEU A 343
ARG A 277
 None
 0.55A 5hnzB-2aj4A:
undetectable		 5hnzB-2aj4A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bv7 GLYCOLIPID TRANSFER
PROTEIN

(Bos taurus) 		PF08718
(GLTP) 		3 LEU A 101
LEU A  30
ARG A 181
 None
GM3  A1212 ( 4.8A)
None
 0.58A 5hnzB-2bv7A:
undetectable		 5hnzB-2bv7A:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4t 5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE

(Streptomyces
cattleya) 		PF01887
(SAM_adeno_trans) 		3 LEU A 267
LEU A 250
ARG A 277
 None
 0.53A 5hnzB-2c4tA:
undetectable		 5hnzB-2c4tA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cjw GTP-BINDING PROTEIN
GEM

(Homo sapiens) 		PF00071
(Ras) 		3 LEU A  91
LEU A 231
ARG A  77
 None
 0.63A 5hnzB-2cjwA:
2.1		 5hnzB-2cjwA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cxh PROBABLE BRIX-DOMAIN
RIBOSOMAL BIOGENESIS
PROTEIN

(Aeropyrum
pernix) 		no annotation 3 LEU A  35
LEU A 182
ARG A 109
 None
 0.48A 5hnzB-2cxhA:
undetectable		 5hnzB-2cxhA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1c ISOCITRATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00180
(Iso_dh) 		3 LEU A 462
LEU A 477
ARG A 471
 None
 0.66A 5hnzB-2d1cA:
undetectable		 5hnzB-2d1cA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epj GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Aeropyrum
pernix) 		PF00202
(Aminotran_3) 		3 LEU A 363
LEU A 424
ARG A 331
 None
 0.61A 5hnzB-2epjA:
undetectable		 5hnzB-2epjA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fef HYPOTHETICAL PROTEIN
PA2201

(Pseudomonas
aeruginosa) 		PF08929
(DUF1911) 		3 LEU A 263
LEU A 207
ARG A 231
 None
 0.62A 5hnzB-2fefA:
undetectable		 5hnzB-2fefA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fhp METHYLASE, PUTATIVE

(Enterococcus
faecalis) 		PF03602
(Cons_hypoth95) 		3 LEU A 132
LEU A 119
ARG A 102
 None
 0.53A 5hnzB-2fhpA:
undetectable		 5hnzB-2fhpA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqx MEMBRANE LIPOPROTEIN
TMPC

(Treponema
pallidum) 		PF02608
(Bmp) 		3 LEU A 255
LEU A 302
ARG A 261
 None
 0.58A 5hnzB-2fqxA:
1.9		 5hnzB-2fqxA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g37 PROLINE
DEHYDROGENASE/DELTA-
1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE

(Thermus
thermophilus) 		PF01619
(Pro_dh) 		3 LEU A  45
LEU A  60
ARG A 263
 None
 0.41A 5hnzB-2g37A:
2.8		 5hnzB-2g37A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gd2 PROBABLE
ALPHA-METHYLACYL-COA
RACEMASE MCR

(Mycobacterium
tuberculosis) 		PF02515
(CoA_transf_3) 		3 LEU A 275
LEU A 252
ARG A 233
 None
 0.39A 5hnzB-2gd2A:
undetectable		 5hnzB-2gd2A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2glj PROBABLE M18-FAMILY
AMINOPEPTIDASE 1

(Clostridium
acetobutylicum) 		PF02127
(Peptidase_M18) 		3 LEU A 118
LEU A 225
ARG A  42
 None
 0.60A 5hnzB-2gljA:
undetectable		 5hnzB-2gljA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gs9 HYPOTHETICAL PROTEIN
TT1324

(Thermus
thermophilus) 		PF08241
(Methyltransf_11) 		3 LEU A 182
LEU A  19
ARG A 146
 None
 0.60A 5hnzB-2gs9A:
2.7		 5hnzB-2gs9A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h0a TRANSCRIPTIONAL
REGULATOR

(Thermus
thermophilus) 		PF13377
(Peripla_BP_3) 		3 LEU A 246
LEU A 235
ARG A 331
 None
 0.66A 5hnzB-2h0aA:
undetectable		 5hnzB-2h0aA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h7v PROTEIN KINASE YPKA

(Yersinia
pseudotuberculosis) 		PF09632
(Rac1) 		3 LEU C 693
LEU C 714
ARG C 684
 None
 0.49A 5hnzB-2h7vC:
undetectable		 5hnzB-2h7vC:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iag PROSTACYCLIN
SYNTHASE

(Homo sapiens) 		PF00067
(p450) 		3 LEU A 164
LEU A 464
ARG A 197
 None
 0.56A 5hnzB-2iagA:
undetectable		 5hnzB-2iagA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iag PROSTACYCLIN
SYNTHASE

(Homo sapiens) 		PF00067
(p450) 		3 LEU A 384
LEU A  54
ARG A  25
 None
 0.61A 5hnzB-2iagA:
undetectable		 5hnzB-2iagA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ici EXOTOXIN I

(Streptococcus
pyogenes) 		PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C) 		3 LEU A 146
LEU A 222
ARG A 163
 None
 0.57A 5hnzB-2iciA:
undetectable		 5hnzB-2iciA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iou PERTACTIN
EXTRACELLULAR DOMAIN

(Bordetella
bronchiseptica) 		PF03212
(Pertactin) 		3 LEU G 477
LEU G 497
ARG G 427
 None
 0.62A 5hnzB-2iouG:
undetectable		 5hnzB-2iouG:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ip4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Thermus
thermophilus) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		3 LEU A  15
LEU A 298
ARG A  27
 None
 0.66A 5hnzB-2ip4A:
undetectable		 5hnzB-2ip4A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ixm SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
REGULATORY SUBUNIT
B'

(Homo sapiens) 		PF03095
(PTPA) 		3 LEU A 139
LEU A  84
ARG A 106
 None
 0.66A 5hnzB-2ixmA:
undetectable		 5hnzB-2ixmA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jeo URIDINE-CYTIDINE
KINASE 1

(Homo sapiens) 		PF00485
(PRK) 		3 LEU A  47
LEU A 231
ARG A  55
 None
 0.63A 5hnzB-2jeoA:
undetectable		 5hnzB-2jeoA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kbq HARMONIN

(Homo sapiens) 		no annotation 3 LEU A  26
LEU A  58
ARG A   3
 None
 0.66A 5hnzB-2kbqA:
undetectable		 5hnzB-2kbqA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l7b APOLIPOPROTEIN E

(Homo sapiens) 		PF01442
(Apolipoprotein) 		3 LEU A 159
LEU A  71
ARG A  15
 None
 0.54A 5hnzB-2l7bA:
undetectable		 5hnzB-2l7bA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lak AHSA1-LIKE PROTEIN
RHE_CH02687

(Rhizobium etli) 		PF08327
(AHSA1) 		3 LEU A  27
LEU A 134
ARG A  74
 None
 0.56A 5hnzB-2lakA:
undetectable		 5hnzB-2lakA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lf8 TRANSCRIPTION FACTOR
ETV6

(Mus musculus) 		PF00178
(Ets) 		3 LEU A 344
LEU A 372
ARG A 414
 None
 0.44A 5hnzB-2lf8A:
undetectable		 5hnzB-2lf8A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2x HYPOTHETICAL PROTEIN

(Mesorhizobium
loti) 		PF13242
(Hydrolase_like) 		3 LEU A 157
LEU A 204
ARG A  37
 None
 0.62A 5hnzB-2o2xA:
3.8		 5hnzB-2o2xA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ob1 LEUCINE CARBOXYL
METHYLTRANSFERASE 1

(Saccharomyces
cerevisiae) 		PF04072
(LCM) 		3 LEU A  49
LEU A  13
ARG A 141
 None
 0.40A 5hnzB-2ob1A:
undetectable		 5hnzB-2ob1A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogx MOLYBDENUM STORAGE
PROTEIN SUBUNIT
ALPHA

(Azotobacter
vinelandii) 		PF00696
(AA_kinase) 		3 LEU A  75
LEU A 141
ARG A  66
 None
 0.45A 5hnzB-2ogxA:
undetectable		 5hnzB-2ogxA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p8e PPM1B BETA ISOFORM
VARIANT 6

(Homo sapiens) 		PF00481
(PP2C) 		3 LEU A 268
LEU A 262
ARG A 153
 None
 0.63A 5hnzB-2p8eA:
undetectable		 5hnzB-2p8eA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pl3 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX10

(Homo sapiens) 		PF00270
(DEAD) 		3 LEU A  76
LEU A 104
ARG A  50
 None
 0.46A 5hnzB-2pl3A:
2.6		 5hnzB-2pl3A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2py6 METHYLTRANSFERASE
FKBM

(Methylobacillus
flagellatus) 		PF05050
(Methyltransf_21) 		3 LEU A 393
LEU A 176
ARG A 386
 None
 0.61A 5hnzB-2py6A:
1.3		 5hnzB-2py6A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Homo sapiens) 		PF00348
(polyprenyl_synt) 		3 LEU A 158
LEU A 114
ARG A 278
 None
 0.54A 5hnzB-2q80A:
undetectable		 5hnzB-2q80A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qq8 TBC1 DOMAIN FAMILY
MEMBER 14

(Homo sapiens) 		PF00566
(RabGAP-TBC) 		3 LEU A 398
LEU A 367
ARG A 587
 None
 0.50A 5hnzB-2qq8A:
undetectable		 5hnzB-2qq8A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r3u PROTEASE DEGS

(Escherichia
coli) 		PF13365
(Trypsin_2) 		3 LEU A 138
LEU A 108
ARG A  52
 None
 0.62A 5hnzB-2r3uA:
undetectable		 5hnzB-2r3uA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rk0 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE
DOMAIN

(Frankia sp.
EAN1pec) 		PF00903
(Glyoxalase) 		3 LEU A  76
LEU A  11
ARG A  70
 None
 0.61A 5hnzB-2rk0A:
undetectable		 5hnzB-2rk0A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uvf EXOPOLYGALACTURONASE

(Yersinia
enterocolitica) 		PF00295
(Glyco_hydro_28)
PF12708
(Pectate_lyase_3) 		3 LEU A 201
LEU A 217
ARG A 330
 None
 0.59A 5hnzB-2uvfA:
undetectable		 5hnzB-2uvfA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v5d O-GLCNACASE NAGJ

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C)
PF02838
(Glyco_hydro_20b)
PF07555
(NAGidase) 		3 LEU A 162
LEU A 135
ARG A  83
 None
 0.64A 5hnzB-2v5dA:
1.8		 5hnzB-2v5dA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vak SIGMA A

(Avian
orthoreovirus) 		PF03084
(Sigma_1_2) 		3 LEU A 338
LEU A 229
ARG A 157
 None
 0.56A 5hnzB-2vakA:
undetectable		 5hnzB-2vakA:
22.67