SIMILAR PATTERNS OF AMINO ACIDS FOR 5HNX_B_TA1B902_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1idu VANADIUM
CHLOROPEROXIDASE

(Curvularia
inaequalis) 		PF01569
(PAP2) 		5 VAL A 340
ASP A 344
LEU A  57
LEU A 113
ARG A 232
 None
 1.19A 5hnxB-1iduA:
undetectable		 5hnxB-1iduA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1izc MACROPHOMATE
SYNTHASE
INTERMOLECULAR
DIELS-ALDERASE

(Macrophoma
commelinae) 		PF03328
(HpcH_HpaI) 		5 VAL A 122
LEU A  28
PHE A  66
LEU A  43
THR A  42
 None
 1.34A 5hnxB-1izcA:
2.6		 5hnxB-1izcA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmo HEPARIN COFACTOR II

(Homo sapiens) 		PF00079
(Serpin) 		5 VAL A 452
ASP A 453
LEU A 350
THR A 349
ARG A 295
 None
None
None
None
TYS  A  60 ( 3.9A)
 1.38A 5hnxB-1jmoA:
undetectable		 5hnxB-1jmoA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k5s PENICILLIN G ACYLASE
BETA SUBUNIT

(Escherichia
coli) 		PF01804
(Penicil_amidase) 		5 VAL B 543
ASP B 542
HIS B  38
LEU B  37
LEU B  55
 None
 1.08A 5hnxB-1k5sB:
undetectable		 5hnxB-1k5sB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kya LACCASE

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 VAL A 425
ASP A 424
LEU A 148
THR A 147
ARG A 199
 None
 1.40A 5hnxB-1kyaA:
undetectable		 5hnxB-1kyaA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oy3 TRANSCRIPTION FACTOR
INHIBITOR
I-KAPPA-B-BETA

(Mus musculus) 		PF12796
(Ank_2)
PF13637
(Ank_4) 		5 LEU D 200
LEU D 226
ARG D 136
PRO D 244
ARG D 242
 None
 1.38A 5hnxB-1oy3D:
undetectable		 5hnxB-1oy3D:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhg ATP-DEPENDENT
HELICASE PCRA

(Geobacillus
stearothermophilus) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		5 ASP A 632
GLU A 582
LEU A 577
LEU A 564
THR A 563
 None
 1.02A 5hnxB-1qhgA:
undetectable		 5hnxB-1qhgA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhh PROTEIN (PCRA
(SUBUNIT))

(Geobacillus
stearothermophilus) 		PF13361
(UvrD_C) 		5 ASP D 632
GLU D 582
LEU D 577
LEU D 564
THR D 563
 None
 0.95A 5hnxB-1qhhD:
undetectable		 5hnxB-1qhhD:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrq SARCOSINE OXIDASE
ALPHA SUBUNIT

(Corynebacterium
sp. U-96) 		PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF12831
(FAD_oxidored)
PF13510
(Fer2_4) 		6 VAL A 907
GLU A 885
LEU A 875
PHE A 920
LEU A 954
ARG A 929
 None
None
None
None
None
SO4  A2008 (-3.1A)
 1.34A 5hnxB-1vrqA:
1.0		 5hnxB-1vrqA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z0n 5'-AMP-ACTIVATED
PROTEIN KINASE,
BETA-1 SUBUNIT

(Rattus
norvegicus) 		PF16561
(AMPK1_CBM) 		5 LEU A 103
PHE A  97
LEU A 116
THR A  80
ARG A  83
 None
 1.35A 5hnxB-1z0nA:
undetectable		 5hnxB-1z0nA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a81 CARB

(Pectobacterium
carotovorum) 		PF00378
(ECH_1) 		5 ASP A 117
PHE A  58
LEU A  15
THR A  14
ARG A  11
 None
 1.38A 5hnxB-2a81A:
undetectable		 5hnxB-2a81A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aka DYNAMIN-1

(Rattus
norvegicus) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M) 		5 VAL B  64
LEU B 134
THR B 133
PRO B  68
ARG B  67
 None
 1.37A 5hnxB-2akaB:
undetectable		 5hnxB-2akaB:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dc0 PROBABLE AMIDASE

(Thermus
thermophilus) 		PF01425
(Amidase) 		5 VAL A  78
GLU A  97
LEU A  70
LEU A 219
THR A 220
 None
 1.32A 5hnxB-2dc0A:
undetectable		 5hnxB-2dc0A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2exh BETA-D-XYLOSIDASE

(Geobacillus
stearothermophilus) 		PF04616
(Glyco_hydro_43) 		5 HIS A 264
LEU A 265
SER A 236
THR A  10
PRO A 243
 None
 1.28A 5hnxB-2exhA:
undetectable		 5hnxB-2exhA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fbi PROBABLE
TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa) 		PF01047
(MarR) 		5 ASP A  86
LEU A  54
LEU A  69
THR A  66
ARG A  88
 None
 1.35A 5hnxB-2fbiA:
undetectable		 5hnxB-2fbiA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gah HETEROTETRAMERIC
SARCOSINE OXIDASE
ALPHA-SUBUNIT

(Stenotrophomonas
maltophilia) 		PF01571
(GCV_T)
PF07992
(Pyr_redox_2)
PF08669
(GCV_T_C)
PF13510
(Fer2_4) 		6 VAL A 908
GLU A 886
LEU A 876
PHE A 921
LEU A 955
ARG A 930
 None
 1.39A 5hnxB-2gahA:
undetectable		 5hnxB-2gahA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hb6 LEUCINE
AMINOPEPTIDASE 1

(Caenorhabditis
elegans) 		PF00883
(Peptidase_M17) 		5 ASP A 382
GLU A 388
LEU A 249
LEU A 298
THR A 297
 None
GOL  A2012 (-3.1A)
None
None
None
 1.40A 5hnxB-2hb6A:
undetectable		 5hnxB-2hb6A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ovl PUTATIVE RACEMASE

(Streptomyces
coelicolor) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 VAL A 301
ASP A 303
HIS A 321
PHE A  31
LEU A  16
 None
 1.30A 5hnxB-2ovlA:
undetectable		 5hnxB-2ovlA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pjr PROTEIN (HELICASE
PCRA)

(Geobacillus
stearothermophilus) 		PF13361
(UvrD_C) 		5 ASP B 632
GLU B 582
LEU B 577
LEU B 564
THR B 563
 None
 1.05A 5hnxB-2pjrB:
undetectable		 5hnxB-2pjrB:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pjr PROTEIN (HELICASE
PCRA)

(Geobacillus
stearothermophilus) 		PF13361
(UvrD_C) 		5 GLU B 582
LEU B 577
SER B 635
LEU B 564
THR B 563
 None
 1.37A 5hnxB-2pjrB:
undetectable		 5hnxB-2pjrB:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wfw ARC

(Rhodococcus
erythropolis) 		PF16450
(Prot_ATP_ID_OB) 		5 VAL A 205
ASP A 206
GLU A 142
LEU A 157
SER A 144
 None
 1.40A 5hnxB-2wfwA:
undetectable		 5hnxB-2wfwA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ws2 GLUTATHIONE
S-TRANSFERASE

(Haemonchus
contortus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 VAL A  88
ASP A  89
GLU A  85
LEU A 153
LEU A  24
 None
 1.27A 5hnxB-2ws2A:
undetectable		 5hnxB-2ws2A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		5 VAL A 277
HIS A 247
LEU A 168
THR A 169
PRO A 146
 None
 1.24A 5hnxB-2wtbA:
undetectable		 5hnxB-2wtbA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x50 TRYPANOTHIONE
REDUCTASE

(Leishmania
infantum) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 VAL A 137
GLU A 149
PHE A 122
LEU A  48
THR A  39
 None
None
None
None
SO4  A1491 (-3.2A)
 1.28A 5hnxB-2x50A:
undetectable		 5hnxB-2x50A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyb LACCASE

(Trametes
cinnabarina) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 VAL A 425
ASP A 424
LEU A 148
THR A 147
ARG A 199
 None
 1.40A 5hnxB-2xybA:
undetectable		 5hnxB-2xybA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zie PUTATIVE
MODIFICATION
METHYLASE

(Thermus
thermophilus) 		PF01555
(N6_N4_Mtase) 		5 VAL A  32
HIS A  25
LEU A  24
LEU A 250
ARG A 259
 None
 1.38A 5hnxB-2zieA:
2.5		 5hnxB-2zieA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5i FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA

(Salmonella
enterica) 		PF00771
(FHIPEP) 		5 HIS A 538
LEU A 541
PHE A 400
LEU A 545
PRO A 403
 None
 1.28A 5hnxB-3a5iA:
undetectable		 5hnxB-3a5iA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e73 LANC-LIKE PROTEIN 1

(Homo sapiens) 		PF05147
(LANC_like) 		5 VAL A  78
ASP A  77
LEU A 386
LEU A 333
THR A 334
 None
 1.23A 5hnxB-3e73A:
undetectable		 5hnxB-3e73A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3efm FERRIC ALCALIGIN
SIDEROPHORE RECEPTOR

(Bordetella
pertussis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 VAL A 219
LEU A 158
SER A 221
LEU A  25
THR A  26
 None
 1.34A 5hnxB-3efmA:
undetectable		 5hnxB-3efmA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fhc NUCLEAR PORE COMPLEX
PROTEIN NUP214

(Homo sapiens) 		PF12894
(ANAPC4_WD40) 		5 VAL A 366
LEU A  98
PHE A  52
LEU A 107
THR A 106
 None
 1.23A 5hnxB-3fhcA:
undetectable		 5hnxB-3fhcA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fp9 PROTEASOME-ASSOCIATE
D ATPASE

(Mycobacterium
tuberculosis) 		PF16450
(Prot_ATP_ID_OB) 		5 VAL A 222
ASP A 223
GLU A 160
LEU A 175
SER A 162
 None
 1.40A 5hnxB-3fp9A:
undetectable		 5hnxB-3fp9A:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdn R-OXYNITRILE LYASE
ISOENZYME 1

(Prunus dulcis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 VAL A 291
HIS A 288
LEU A 228
THR A 229
ARG A 475
 None
 1.30A 5hnxB-3gdnA:
undetectable		 5hnxB-3gdnA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ieh PUTATIVE
METALLOPEPTIDASE

(Shewanella
baltica) 		PF04952
(AstE_AspA) 		5 GLU A 124
LEU A  45
LEU A 105
PRO A 126
ARG A 128
 None
 1.31A 5hnxB-3iehA:
undetectable		 5hnxB-3iehA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kxw SAFRAMYCIN MX1
SYNTHETASE B

(Legionella
pneumophila) 		PF00501
(AMP-binding) 		5 HIS A 187
LEU A  11
PHE A  80
LEU A  81
ARG A  65
 None
 0.97A 5hnxB-3kxwA:
undetectable		 5hnxB-3kxwA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kxw SAFRAMYCIN MX1
SYNTHETASE B

(Legionella
pneumophila) 		PF00501
(AMP-binding) 		5 VAL A 185
LEU A  11
PHE A  80
LEU A  81
ARG A  65
 None
 1.37A 5hnxB-3kxwA:
undetectable		 5hnxB-3kxwA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lmd GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Corynebacterium
glutamicum) 		PF00348
(polyprenyl_synt) 		5 GLU A 273
LEU A 299
SER A 305
PHE A 244
ARG A 272
 None
 1.30A 5hnxB-3lmdA:
undetectable		 5hnxB-3lmdA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzs CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME

(Bos taurus) 		PF00067
(p450) 		5 LEU A 300
SER A 306
LEU A 437
THR A 434
PRO A 398
 None
 0.98A 5hnxB-3mzsA:
undetectable		 5hnxB-3mzsA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nv9 MALIC ENZYME

(Entamoeba
histolytica) 		PF00390
(malic)
PF03949
(Malic_M) 		5 VAL A 421
ASP A 420
GLU A 417
LEU A 371
PRO A 415
 None
 1.30A 5hnxB-3nv9A:
undetectable		 5hnxB-3nv9A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qwx CELL DEATH
ABNORMALITY PROTEIN
2

(Caenorhabditis
elegans) 		PF00017
(SH2)
PF00018
(SH3_1) 		5 VAL X  82
LEU X  51
PHE X  99
LEU X 104
THR X 105
 None
 1.33A 5hnxB-3qwxX:
undetectable		 5hnxB-3qwxX:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r4v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pseudomonas
phage 201phi2-1) 		PF00091
(Tubulin) 		5 VAL A 260
HIS A 183
PHE A 267
LEU A 230
ARG A 173
 None
 1.35A 5hnxB-3r4vA:
20.8		 5hnxB-3r4vA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rc3 ATP-DEPENDENT RNA
HELICASE SUPV3L1,
MITOCHONDRIAL

(Homo sapiens) 		PF00271
(Helicase_C)
PF12513
(SUV3_C) 		5 VAL A  69
HIS A 165
PHE A 170
LEU A 115
PRO A  66
 None
 1.34A 5hnxB-3rc3A:
undetectable		 5hnxB-3rc3A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos taurus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 GLU C 929
SER C 928
PHE C1271
THR C1301
ARG C1306
 None
 1.29A 5hnxB-3sr6C:
undetectable		 5hnxB-3sr6C:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t2n SERINE PROTEASE
HEPSIN

(Homo sapiens) 		PF00089
(Trypsin)
PF09272
(Hepsin-SRCR) 		5 VAL A 120
ASP A 121
GLU A 122
LEU A  63
SER A  79
 None
 1.40A 5hnxB-3t2nA:
undetectable		 5hnxB-3t2nA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tk3 CYTOCHROME P450 2B4

(Oryctolagus
cuniculus) 		PF00067
(p450) 		5 VAL A 113
LEU A 288
SER A 128
PHE A 283
ARG A 122
 HEM  A 500 (-4.7A)
None
None
None
None
 1.40A 5hnxB-3tk3A:
undetectable		 5hnxB-3tk3A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4amm DYNE8

(Micromonospora
chersina) 		PF00698
(Acyl_transf_1) 		5 VAL A 841
GLU A 834
LEU A 564
LEU A 557
ARG A 838
 None
 1.26A 5hnxB-4ammA:
undetectable		 5hnxB-4ammA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cke MRNA-CAPPING ENZYME
REGULATORY SUBUNIT

(Vaccinia virus) 		PF03341
(Pox_mRNA-cap) 		6 ASP B 192
HIS B 260
LEU B 263
SER B 188
LEU B  61
THR B  58
 None
 1.47A 5hnxB-4ckeB:
undetectable		 5hnxB-4ckeB:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dyo ASPARTYL
AMINOPEPTIDASE

(Homo sapiens) 		PF02127
(Peptidase_M18) 		5 GLU A 444
LEU A 100
LEU A 134
THR A 135
PRO A 261
 None
 1.31A 5hnxB-4dyoA:
3.6		 5hnxB-4dyoA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fe4 XYLOSE OPERON
REGULATORY PROTEIN

(Escherichia
coli) 		PF12833
(HTH_18)
PF13377
(Peripla_BP_3) 		5 VAL A 386
ASP A 385
GLU A 382
LEU A 339
PRO A 380
 None
 1.34A 5hnxB-4fe4A:
3.2		 5hnxB-4fe4A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jza UNCHARACTERIZED
PROTEIN

(Legionella
longbeachae) 		no annotation 5 VAL A 157
ASP A 156
LEU A 149
LEU A 599
ARG A 591
 None
 1.37A 5hnxB-4jzaA:
undetectable		 5hnxB-4jzaA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0h CONSERVED
HYPOTHETICAL
PROTEIN, PUTATIVE
ANTI-SIGMA FACTOR

(Parabacteroides
distasonis) 		PF04773
(FecR)
PF16344
(DUF4974) 		5 VAL A 203
PHE A 185
LEU A 140
THR A 139
ARG A 217
 None
 1.40A 5hnxB-4m0hA:
undetectable		 5hnxB-4m0hA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m73 METHYLTRANSFERASE
MPPJ

(Streptomyces
hygroscopicus) 		PF13649
(Methyltransf_25) 		5 VAL A 332
LEU A 336
LEU A 255
THR A 254
PRO A 303
 None
 1.33A 5hnxB-4m73A:
2.5		 5hnxB-4m73A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4me3 DNA REPLICATION
LICENSING FACTOR MCM
RELATED PROTEIN

(Thermoplasma
acidophilum) 		PF17207
(MCM_OB) 		5 VAL A  73
PHE A  55
LEU A  48
ARG A  93
ARG A  68
 None
 1.15A 5hnxB-4me3A:
undetectable		 5hnxB-4me3A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ol8 REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Saccharomyces
cerevisiae) 		PF00078
(RVT_1) 		5 LEU A 409
PHE A 412
LEU A 355
THR A 356
ARG A 300
 None
None
None
None
A  C   8 ( 4.2A)
 1.03A 5hnxB-4ol8A:
undetectable		 5hnxB-4ol8A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pel PENICILLIN G ACYLASE
SUBUNIT BETA

(Kluyvera
cryocrescens) 		PF01804
(Penicil_amidase) 		5 VAL B 543
ASP B 542
HIS B  38
LEU B  37
LEU B  55
 None
 1.06A 5hnxB-4pelB:
undetectable		 5hnxB-4pelB:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4per ANGIOGENIN
RIBONUCLEASE
INHIBITOR

(Gallus gallus) 		PF00074
(RnaseA)
PF13516
(LRR_6) 		5 VAL A 438
ASP A 439
LEU A 413
LEU A 400
ARG B  41
 None
 1.07A 5hnxB-4perA:
undetectable		 5hnxB-4perA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pgh CAFFEIC ACID
O-METHYLTRANSFERASE

(Sorghum bicolor) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		5 VAL A 298
GLU A 331
PHE A 360
LEU A 278
ARG A 332
 None
 1.37A 5hnxB-4pghA:
undetectable		 5hnxB-4pghA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ri6 PHI CLASS
GLUTATHIONE
TRANSFERASE GSTF1

(Populus tremula
x Populus
tremuloides) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 VAL A 128
ASP A 129
GLU A 130
LEU A 122
LEU A 176
 None
 1.21A 5hnxB-4ri6A:
undetectable		 5hnxB-4ri6A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u3a ENDOGLUCANASE H

(Ruminiclostridium
thermocellum) 		PF00150
(Cellulase) 		5 VAL A 153
ASP A 154
LEU A 203
PHE A 204
THR A 236
 None
 1.33A 5hnxB-4u3aA:
undetectable		 5hnxB-4u3aA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u7t DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A

(Homo sapiens) 		PF00145
(DNA_methylase) 		5 VAL A 687
LEU A 738
PHE A 755
LEU A 773
ARG A 729
 SAH  A1004 (-3.7A)
None
None
None
None
 1.34A 5hnxB-4u7tA:
undetectable		 5hnxB-4u7tA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjv RIBOSOME ASSEMBLY
PROTEIN 4

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		5 HIS A 325
LEU A 326
SER A 234
LEU A 328
THR A 330
 None
 1.31A 5hnxB-4wjvA:
undetectable		 5hnxB-4wjvA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yef 5'-AMP-ACTIVATED
PROTEIN KINASE
SUBUNIT BETA-1

(Rattus
norvegicus) 		PF16561
(AMPK1_CBM) 		5 LEU A 103
PHE A  97
LEU A 116
THR A  80
ARG A  83
 None
 1.37A 5hnxB-4yefA:
undetectable		 5hnxB-4yefA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysw XANTHINE
DEHYDROGENASE/OXIDAS
E

(Rattus
norvegicus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 GLU A 929
SER A 928
PHE A1271
THR A1300
ARG A1305
 None
 1.35A 5hnxB-4yswA:
undetectable		 5hnxB-4yswA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zo6 LIN1840 PROTEIN

(Listeria
innocua) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 VAL A 428
GLU A 427
LEU A 539
LEU A 525
ARG A 426
 None
 0.78A 5hnxB-4zo6A:
5.6		 5hnxB-4zo6A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE

(Neurospora
crassa) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		5 VAL A 161
GLU A 210
HIS A  68
SER A 165
PHE A 117
 None
 1.31A 5hnxB-4ztxA:
1.5		 5hnxB-4ztxA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a3f DYNAMIN 3

(Homo sapiens) 		PF00169
(PH)
PF00350
(Dynamin_N)
PF01031
(Dynamin_M)
PF02212
(GED) 		5 VAL A 592
LEU A 546
LEU A 522
THR A 523
ARG A 597
 None
 1.30A 5hnxB-5a3fA:
undetectable		 5hnxB-5a3fA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cj4 XRCC4-MYH7-(1562-162
2) CHIMERA PROTEIN

(Homo sapiens) 		PF06632
(XRCC4) 		5 VAL A  22
LEU A  36
SER A   6
PHE A  86
ARG A  71
 MLY  A   4 ( 4.2A)
None
None
None
None
 1.35A 5hnxB-5cj4A:
undetectable		 5hnxB-5cj4A:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cju ISOBUTYRYL-COA
MUTASE FUSED

(Cupriavidus
metallidurans) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding)
PF03308
(ArgK) 		5 ASP A 360
SER A 435
THR A 226
ARG A 265
ARG A 361
 GDP  A1104 (-3.0A)
None
None
GDP  A1104 (-3.5A)
None
 1.37A 5hnxB-5cjuA:
0.4		 5hnxB-5cjuA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cow PUTATIVE
UNCHARACTERIZED
PROTEIN

(Caenorhabditis
remanei) 		no annotation 5 VAL A 303
PHE A 368
LEU A 272
THR A 271
ARG A 292
 None
None
None
None
SO4  A 502 (-4.3A)
 1.30A 5hnxB-5cowA:
undetectable		 5hnxB-5cowA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyr RNA-DEPENDENT RNA
POLYMERASE

(Thosea asigna
virus) 		no annotation 5 VAL B 293
SER B 297
PHE B 446
LEU B 436
ARG B 429
 None
 1.05A 5hnxB-5cyrB:
undetectable		 5hnxB-5cyrB:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9a BETA-GALACTOSIDASE

(Rahnella sp. R3) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		5 VAL A  83
LEU A 139
LEU A  57
THR A  65
PRO A  22
 None
 1.29A 5hnxB-5e9aA:
1.6		 5hnxB-5e9aA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fby CLEAVED PEPTIDE
SEPARASE

(Chaetomium
thermophilum;
synthetic
construct) 		PF03568
(Peptidase_C50)
no annotation 		5 ASP A1723
LEU B  16
SER A1720
LEU A1699
THR A1696
 None
 1.37A 5hnxB-5fbyA:
undetectable		 5hnxB-5fbyA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g1q CLP PROTEASE
PROTEOLYTIC SUBUNIT
P

(Francisella
tularensis) 		PF00574
(CLP_protease) 		5 ASP A  82
LEU A 107
LEU A 188
THR A 161
ARG A 152
 None
 1.35A 5hnxB-5g1qA:
undetectable		 5hnxB-5g1qA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5khn RND TRANSPORTER

(Burkholderia
multivorans) 		no annotation 5 VAL B 189
LEU B 182
SER B 609
LEU B 164
ARG B 577
 None
 1.14A 5hnxB-5khnB:
undetectable		 5hnxB-5khnB:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5khn RND TRANSPORTER

(Burkholderia
multivorans) 		no annotation 5 VAL B 189
LEU B 182
SER B 609
LEU B 164
ARG B 621
 None
 1.28A 5hnxB-5khnB:
undetectable		 5hnxB-5khnB:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ku7 TIR-NB-LRR TYPE
RESISTANCE PROTEIN
RPV1

(Vitis
rotundifolia) 		PF01582
(TIR) 		5 VAL A 119
GLU A  86
LEU A 153
SER A 130
LEU A  95
 None
 1.34A 5hnxB-5ku7A:
undetectable		 5hnxB-5ku7A:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kwa PROTEASOME-ASSOCIATE
D ATPASE

(Mycobacterium
tuberculosis) 		PF00004
(AAA)
PF16450
(Prot_ATP_ID_OB) 		5 VAL A 222
ASP A 223
GLU A 160
LEU A 175
SER A 162
 None
 1.40A 5hnxB-5kwaA:
undetectable		 5hnxB-5kwaA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5la7 HEPARANASE

(Homo sapiens) 		PF03662
(Glyco_hydro_79n) 		5 LEU A 464
SER A 528
LEU A 452
THR A 451
ARG A 535
 None
 1.37A 5hnxB-5la7A:
undetectable		 5hnxB-5la7A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5li8 PUTATIVE CYTOCHROME
P450 126

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		5 VAL A 294
GLU A 291
LEU A  64
THR A  60
ARG A 348
 None
 1.39A 5hnxB-5li8A:
undetectable		 5hnxB-5li8A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5loi RAD26

(Thermothelomyces
thermophila) 		PF12331
(DUF3636) 		5 ASP A 499
LEU A 492
SER A 569
ARG A 511
PRO A 573
 None
 1.21A 5hnxB-5loiA:
undetectable		 5hnxB-5loiA:
21.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mjs TUBULIN BETA CHAIN

(Schizosaccharomyces
pombe) 		no annotation 5 ASP A  26
GLU A  27
HIS A 227
LEU A 228
PRO A 357
 None
 1.11A 5hnxB-5mjsA:
54.4		 5hnxB-5mjsA:
59.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 6 VAL B  23
ASP B  26
GLU B  27
HIS B 229
LEU B 230
THR B 276
 None
 1.33A 5hnxB-5n5nB:
54.6		 5hnxB-5n5nB:
97.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 6 VAL B  23
ASP B  26
GLU B  27
HIS B 229
SER B 236
THR B 276
 None
 1.16A 5hnxB-5n5nB:
54.6		 5hnxB-5n5nB:
97.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 7 VAL B  23
GLU B  27
HIS B 229
LEU B 230
PHE B 272
THR B 276
PRO B 360
 None
 0.94A 5hnxB-5n5nB:
54.6		 5hnxB-5n5nB:
97.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 7 VAL B  23
GLU B  27
HIS B 229
SER B 236
PHE B 272
THR B 276
PRO B 360
 None
 0.85A 5hnxB-5n5nB:
54.6		 5hnxB-5n5nB:
97.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 7 VAL B  23
HIS B 229
LEU B 230
PHE B 272
LEU B 275
THR B 276
PRO B 360
 None
 0.92A 5hnxB-5n5nB:
54.6		 5hnxB-5n5nB:
97.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0l RETICULON-4 RECEPTOR

(Mus musculus) 		no annotation 5 GLU A 284
LEU A 233
SER A 283
LEU A 238
PRO A 286
 None
 1.37A 5hnxB-5o0lA:
undetectable		 5hnxB-5o0lA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o7g ALPHA/BETA HYDROLASE
FAMILY PROTEIN

(Bacillus
coagulans) 		no annotation 5 SER A 114
PHE A 143
LEU A 173
PRO A 252
ARG A 283
 None
 1.36A 5hnxB-5o7gA:
undetectable		 5hnxB-5o7gA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olp PECTATE LYASE

(Bacteroides
thetaiotaomicron) 		no annotation 5 ASP A 252
GLU A 254
LEU A 198
SER A 123
LEU A 173
 None
 1.28A 5hnxB-5olpA:
undetectable		 5hnxB-5olpA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tf0 GLYCOSYL HYDROLASE
FAMILY 3 N-TERMINAL
DOMAIN PROTEIN

(Bacteroides
intestinalis) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 LEU A 534
LEU A 564
THR A 565
PRO A 166
ARG A 167
 None
 1.38A 5hnxB-5tf0A:
1.5		 5hnxB-5tf0A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tmh POLYPROTEIN

(Zika virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		5 LEU A 567
THR A 564
ARG A 440
PRO A 392
ARG A 393
 None
 1.31A 5hnxB-5tmhA:
undetectable		 5hnxB-5tmhA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uan RETINOIC ACID
RECEPTOR BETA
RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		no annotation 5 ASP B 376
LEU A 375
SER A 380
LEU A 308
ARG A 421
 None
 1.29A 5hnxB-5uanB:
undetectable		 5hnxB-5uanB:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uc7 ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(environmental
samples) 		PF00202
(Aminotran_3) 		5 GLU A 188
LEU A 228
LEU A 210
ARG A 221
ARG A 189
 None
 1.25A 5hnxB-5uc7A:
undetectable		 5hnxB-5uc7A:
20.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w3j TUBULIN BETA CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		6 VAL B  23
ASP B  26
GLU B  27
LEU B 228
THR B 274
PRO B 358
 TA1  B 502 (-3.9A)
TA1  B 502 (-4.1A)
TA1  B 502 (-3.6A)
None
TA1  B 502 (-4.7A)
None
 0.89A 5hnxB-5w3jB:
54.1		 5hnxB-5w3jB:
75.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w3j TUBULIN BETA CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		5 VAL B  23
ASP B  26
GLU B  27
SER B 234
PRO B 358
 TA1  B 502 (-3.9A)
TA1  B 502 (-4.1A)
TA1  B 502 (-3.6A)
TA1  B 502 ( 4.9A)
None
 0.93A 5hnxB-5w3jB:
54.1		 5hnxB-5w3jB:
75.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wt4 CYSTEINE DESULFURASE
ISCS

(Helicobacter
pylori) 		no annotation 5 VAL A 107
LEU A 216
SER A 149
LEU A 224
THR A 225
 None
 1.11A 5hnxB-5wt4A:
undetectable		 5hnxB-5wt4A:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y92 RECEPTOR-LIKE
PROTEIN KINASE
ANXUR2

(Arabidopsis
thaliana) 		no annotation 5 ASP A  42
HIS A 105
LEU A 104
LEU A 102
ARG A 235
 None
 1.38A 5hnxB-5y92A:
undetectable		 5hnxB-5y92A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yew MITOFUSIN-1,MITOFUSI
N-1 FUSION PROTEIN

(Homo sapiens) 		no annotation 5 GLU B 316
LEU B 204
LEU B 212
THR B 211
ARG B 313
 None
 1.40A 5hnxB-5yewB:
1.5		 5hnxB-5yewB:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6brr DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A

(Homo sapiens) 		no annotation 5 VAL A 687
LEU A 738
PHE A 755
LEU A 773
ARG A 729
 SAH  A1001 (-3.7A)
None
None
None
None
 1.37A 5hnxB-6brrA:
undetectable		 5hnxB-6brrA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ch3 FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA

(Salmonella
enterica) 		no annotation 5 HIS A 538
LEU A 541
PHE A 400
LEU A 545
PRO A 403
 None
 1.20A 5hnxB-6ch3A:
undetectable		 5hnxB-6ch3A:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6etz BETA-GALACTOSIDASE

(Arthrobacter
sp. 32cB) 		no annotation 5 LEU A 756
LEU A 842
THR A 832
ARG A 815
ARG A 740
 None
None
None
MLI  A1106 (-3.6A)
None
 1.24A 5hnxB-6etzA:
undetectable		 5hnxB-6etzA:
11.87