SIMILAR PATTERNS OF AMINO ACIDS FOR 5HNW_B_TA1B902

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bf5 SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA

(Homo sapiens) 		PF00017
(SH2)
PF01017
(STAT_alpha)
PF02864
(STAT_bind) 		5 VAL A 368
LEU A 335
LEU A 433
LEU A 409
THR A 337
 None
 1.18A 5hnwB-1bf5A:
undetectable		 5hnwB-1bf5A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyt CYTOSOL
AMINOPEPTIDASE

(Escherichia
coli) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		5 GLU A 114
LEU A  52
LEU A  28
LEU A  75
THR A  59
 None
 1.11A 5hnwB-1gytA:
undetectable		 5hnwB-1gytA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqo PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Zea mays) 		PF00311
(PEPcase) 		5 VAL A 307
ASP A 306
LEU A 559
ARG A 556
PRO A 301
 None
 1.20A 5hnwB-1jqoA:
1.3		 5hnwB-1jqoA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k5s PENICILLIN G ACYLASE
BETA SUBUNIT

(Escherichia
coli) 		PF01804
(Penicil_amidase) 		5 VAL B 543
ASP B 542
HIS B  38
LEU B  37
LEU B  55
 None
 1.07A 5hnwB-1k5sB:
undetectable		 5hnwB-1k5sB:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kzh PHOSPHOFRUCTOKINASE

(Borreliella
burgdorferi) 		PF00365
(PFK) 		5 LEU A 485
HIS A 213
SER A  59
THR A 483
ARG A  42
 None
 1.16A 5hnwB-1kzhA:
undetectable		 5hnwB-1kzhA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n5x XANTHINE
DEHYDROGENASE

(Bos taurus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 VAL A 330
LEU A 404
LEU A 372
THR A 373
PRO A 410
 None
FAD  A3005 (-4.6A)
None
None
None
 0.98A 5hnwB-1n5xA:
undetectable		 5hnwB-1n5xA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ovm INDOLE-3-PYRUVATE
DECARBOXYLASE

(Enterobacter
cloacae) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 VAL A 517
LEU A 460
LEU A 432
THR A 433
PRO A 455
 None
 1.18A 5hnwB-1ovmA:
undetectable		 5hnwB-1ovmA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhg ATP-DEPENDENT
HELICASE PCRA

(Geobacillus
stearothermophilus) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		5 ASP A 632
GLU A 582
LEU A 577
LEU A 564
THR A 563
 None
 1.05A 5hnwB-1qhgA:
undetectable		 5hnwB-1qhgA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhh PROTEIN (PCRA
(SUBUNIT))

(Geobacillus
stearothermophilus) 		PF13361
(UvrD_C) 		5 ASP D 632
GLU D 582
LEU D 577
LEU D 564
THR D 563
 None
 0.99A 5hnwB-1qhhD:
undetectable		 5hnwB-1qhhD:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tvi HYPOTHETICAL UPF0054
PROTEIN TM1509

(Thermotoga
maritima) 		PF02130
(UPF0054) 		5 VAL A  60
ASP A  59
LEU A  21
LEU A  14
PRO A  78
 None
 1.12A 5hnwB-1tviA:
undetectable		 5hnwB-1tviA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2v ARP2/3 COMPLEX 16KDA
SUBUNIT

(Bos taurus) 		PF04699
(P16-Arc) 		5 VAL G 151
LEU G  98
LEU G 106
LEU G  55
PRO G  37
 None
 1.12A 5hnwB-1u2vG:
undetectable		 5hnwB-1u2vG:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrq SARCOSINE OXIDASE
ALPHA SUBUNIT

(Corynebacterium
sp. U-96) 		PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF12831
(FAD_oxidored)
PF13510
(Fer2_4) 		6 VAL A 907
GLU A 885
LEU A 875
PHE A 920
LEU A 954
ARG A 929
 None
None
None
None
None
SO4  A2008 (-3.1A)
 1.33A 5hnwB-1vrqA:
undetectable		 5hnwB-1vrqA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wjm BETA-SPECTRIN III

(Homo sapiens) 		PF15410
(PH_9) 		5 GLU A   8
LEU A  89
LEU A  44
LEU A  87
ARG A  69
 None
 0.92A 5hnwB-1wjmA:
undetectable		 5hnwB-1wjmA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xa6 BETA2-CHIMAERIN

(Homo sapiens) 		PF00017
(SH2)
PF00130
(C1_1)
PF00620
(RhoGAP) 		5 VAL A 411
LEU A 401
PHE A 429
LEU A 433
ARG A 288
 None
 0.99A 5hnwB-1xa6A:
undetectable		 5hnwB-1xa6A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5m DAMAGE-SPECIFIC DNA
BINDING PROTEIN 1

(Homo sapiens) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		5 VAL A 509
LEU A 602
LEU A 555
LEU A 546
THR A 594
 None
 1.13A 5hnwB-2b5mA:
undetectable		 5hnwB-2b5mA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bfr HYPOTHETICAL PROTEIN
AF1521

(Archaeoglobus
fulgidus) 		PF01661
(Macro) 		5 VAL A 168
LEU A 157
PHE A 137
THR A 155
PRO A 123
 None
 1.13A 5hnwB-2bfrA:
undetectable		 5hnwB-2bfrA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bg9 ACETYLCHOLINE
RECEPTOR PROTEIN,
ALPHA CHAIN

(Torpedo
marmorata) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		5 VAL A 413
LEU A 250
PHE A 225
LEU A 253
THR A 254
 None
 1.21A 5hnwB-2bg9A:
undetectable		 5hnwB-2bg9A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bi0 HYPOTHETICAL PROTEIN
RV0216

(Mycobacterium
tuberculosis) 		no annotation 5 LEU A 109
LEU A  32
THR A  31
ARG A 142
PRO A  64
 None
 1.17A 5hnwB-2bi0A:
undetectable		 5hnwB-2bi0A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d6l LECTIN, GALACTOSE
BINDING, SOLUBLE 9

(Mus musculus) 		PF00337
(Gal-bind_lectin) 		5 VAL X 111
LEU X 141
LEU X 139
THR X  36
PRO X  91
 None
 1.14A 5hnwB-2d6lX:
undetectable		 5hnwB-2d6lX:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d6l LECTIN, GALACTOSE
BINDING, SOLUBLE 9

(Mus musculus) 		PF00337
(Gal-bind_lectin) 		5 VAL X 111
LEU X 141
PHE X  44
LEU X 139
THR X  36
 None
 1.19A 5hnwB-2d6lX:
undetectable		 5hnwB-2d6lX:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gah HETEROTETRAMERIC
SARCOSINE OXIDASE
ALPHA-SUBUNIT

(Stenotrophomonas
maltophilia) 		PF01571
(GCV_T)
PF07992
(Pyr_redox_2)
PF08669
(GCV_T_C)
PF13510
(Fer2_4) 		6 VAL A 908
GLU A 886
LEU A 876
PHE A 921
LEU A 955
ARG A 930
 None
 1.38A 5hnwB-2gahA:
undetectable		 5hnwB-2gahA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oba PROBABLE 6-PYRUVOYL
TETRAHYDROBIOPTERIN
SYNTHASE

(Pseudomonas
aeruginosa) 		PF01242
(PTPS) 		5 LEU A  71
HIS A  30
SER A 111
LEU A  85
ARG A  14
 None
ZN  A 200 (-3.4A)
None
None
None
 1.04A 5hnwB-2obaA:
undetectable		 5hnwB-2obaA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2osa N-CHIMAERIN

(Homo sapiens) 		PF00620
(RhoGAP) 		5 VAL A 404
LEU A 394
PHE A 422
LEU A 426
ARG A 281
 None
 1.05A 5hnwB-2osaA:
undetectable		 5hnwB-2osaA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ovl PUTATIVE RACEMASE

(Streptomyces
coelicolor) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		6 VAL A 301
ASP A 303
LEU A  20
HIS A 321
PHE A  31
LEU A  16
 None
 1.36A 5hnwB-2ovlA:
undetectable		 5hnwB-2ovlA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pjr PROTEIN (HELICASE
PCRA)

(Geobacillus
stearothermophilus) 		PF13361
(UvrD_C) 		5 ASP B 632
GLU B 582
LEU B 577
LEU B 564
THR B 563
 None
 1.08A 5hnwB-2pjrB:
undetectable		 5hnwB-2pjrB:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wl1 PYRIN

(Homo sapiens) 		PF00622
(SPRY)
PF13765
(PRY) 		5 VAL A 587
LEU A 709
HIS A 739
SER A 728
THR A 707
 None
None
None
None
SCN  A1778 ( 4.7A)
 1.05A 5hnwB-2wl1A:
undetectable		 5hnwB-2wl1A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		5 VAL A 277
HIS A 247
LEU A 168
THR A 169
PRO A 146
 None
 1.16A 5hnwB-2wtbA:
undetectable		 5hnwB-2wtbA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yys PROLINE
IMINOPEPTIDASE-RELAT
ED PROTEIN

(Thermus
thermophilus) 		PF12697
(Abhydrolase_6) 		5 VAL A  78
ASP A  79
LEU A 243
LEU A 214
THR A 215
 None
 0.86A 5hnwB-2yysA:
undetectable		 5hnwB-2yysA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9j XANTHINE OXIDASE

(Bos taurus) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		5 VAL B 330
LEU B 404
LEU B 372
THR B 373
PRO B 410
 None
FAD  B 606 (-4.6A)
None
None
None
 0.95A 5hnwB-3b9jB:
undetectable		 5hnwB-3b9jB:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ckl SULFOTRANSFERASE
FAMILY CYTOSOLIC 1B
MEMBER 1

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		5 LEU A  62
PHE A 211
LEU A 212
ARG A 104
PRO A 188
 None
 1.13A 5hnwB-3cklA:
undetectable		 5hnwB-3cklA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e73 LANC-LIKE PROTEIN 1

(Homo sapiens) 		PF05147
(LANC_like) 		5 VAL A  78
ASP A  77
LEU A 386
LEU A 333
THR A 334
 None
 1.17A 5hnwB-3e73A:
undetectable		 5hnwB-3e73A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gut TRANSCRIPTION FACTOR
P65

(Homo sapiens) 		PF00554
(RHD_DNA_bind)
PF16179
(RHD_dimer) 		5 LEU A  90
LEU A 159
PHE A 113
LEU A 116
ARG A  96
 None
 1.05A 5hnwB-3gutA:
undetectable		 5hnwB-3gutA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hww 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE-1-CARBOXYLA
TE SYNTHASE

(Escherichia
coli) 		PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
PF16582
(TPP_enzyme_M_2) 		5 VAL A 237
GLU A 233
LEU A 294
LEU A 289
THR A 290
 None
 0.87A 5hnwB-3hwwA:
undetectable		 5hnwB-3hwwA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3il3 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Haemophilus
influenzae) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 VAL A 116
LEU A 227
LEU A 313
LEU A 237
PRO A 242
 None
 1.13A 5hnwB-3il3A:
undetectable		 5hnwB-3il3A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6i UNCHARACTERIZED
LIPOPROTEIN YCEB

(Escherichia
coli) 		PF07273
(DUF1439) 		5 VAL A 167
LEU A  28
LEU A 105
LEU A  67
THR A  54
 None
 1.19A 5hnwB-3l6iA:
undetectable		 5hnwB-3l6iA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lmd GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Corynebacterium
glutamicum) 		PF00348
(polyprenyl_synt) 		5 VAL A 277
GLU A 273
LEU A 289
SER A 305
LEU A 258
 None
 1.02A 5hnwB-3lmdA:
undetectable		 5hnwB-3lmdA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lsc TRIAZINE HYDROLASE

(Paenarthrobacter
aurescens) 		PF01979
(Amidohydro_1) 		5 LEU A 296
HIS A 238
SER A 161
THR A 324
ARG A 302
 None
ZN  A 458 (-3.2A)
None
None
None
 1.16A 5hnwB-3lscA:
2.4		 5hnwB-3lscA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lvv GLUTAMATE--CYSTEINE
LIGASE

(Saccharomyces
cerevisiae) 		PF03074
(GCS) 		5 VAL A 269
LEU A 596
LEU A 492
LEU A 592
ARG A 602
 None
 1.19A 5hnwB-3lvvA:
undetectable		 5hnwB-3lvvA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzs CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME

(Bos taurus) 		PF00067
(p450) 		5 LEU A 296
LEU A 300
SER A 306
LEU A 437
PRO A 398
 None
 1.12A 5hnwB-3mzsA:
undetectable		 5hnwB-3mzsA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzs CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME

(Bos taurus) 		PF00067
(p450) 		5 LEU A 300
SER A 306
LEU A 437
THR A 434
PRO A 398
 None
 0.87A 5hnwB-3mzsA:
undetectable		 5hnwB-3mzsA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ns1 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos taurus) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		5 VAL B 330
LEU B 404
LEU B 372
THR B 373
PRO B 410
 None
FAD  B 606 (-4.8A)
None
None
None
 0.97A 5hnwB-3ns1B:
undetectable		 5hnwB-3ns1B:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rv2 S-ADENOSYLMETHIONINE
SYNTHASE

(Mycobacterium
marinum) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		5 LEU A 160
LEU A 228
LEU A 156
ARG A 162
PRO A 147
 None
 1.13A 5hnwB-3rv2A:
undetectable		 5hnwB-3rv2A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ryt RAS-RELATED C3
BOTULINUM TOXIN
SUBSTRATE 1

(Homo sapiens) 		PF00071
(Ras) 		5 VAL C 101
LEU C  19
LEU C  79
LEU C  20
THR C  17
 None
None
None
None
GNP  C 179 ( 3.6A)
 1.18A 5hnwB-3rytC:
undetectable		 5hnwB-3rytC:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sbu HYPOTHETICAL
NTF2-LIKE PROTEIN

(Bacteroides
fragilis) 		PF14254
(DUF4348) 		5 ASP A 176
GLU A 175
LEU A 254
LEU A 229
LEU A 265
 None
GOL  A 288 (-3.2A)
MLY  A 255 ( 4.5A)
None
None
 1.13A 5hnwB-3sbuA:
undetectable		 5hnwB-3sbuA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujh GLUCOSE-6-PHOSPHATE
ISOMERASE

(Toxoplasma
gondii) 		PF00342
(PGI) 		5 VAL A 341
GLU A 382
LEU A 490
SER A 329
LEU A 493
 None
None
None
None
CL  A 565 ( 4.4A)
 1.12A 5hnwB-3ujhA:
undetectable		 5hnwB-3ujhA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4o MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1

(Homo sapiens) 		PF00656
(Peptidase_C14) 		6 GLU A 500
LEU A 372
LEU A 515
LEU A 369
THR A 370
PRO A 362
 None
 1.47A 5hnwB-3v4oA:
2.6		 5hnwB-3v4oA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v7n THREONINE SYNTHASE

(Burkholderia
thailandensis) 		PF00291
(PALP)
PF14821
(Thr_synth_N) 		5 LEU A 104
LEU A 411
LEU A 114
ARG A 400
PRO A 432
 None
 1.18A 5hnwB-3v7nA:
2.5		 5hnwB-3v7nA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyn LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4B

(Mus musculus) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 LEU A 278
LEU A 236
LEU A 254
THR A 255
ARG A 304
 None
 1.17A 5hnwB-3zynA:
undetectable		 5hnwB-3zynA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b9y ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B

(Cellvibrio
japonicus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16338
(DUF4968)
PF17137
(DUF5110) 		5 LEU A 740
LEU A 758
LEU A 727
THR A 726
PRO A 572
 None
 1.15A 5hnwB-4b9yA:
undetectable		 5hnwB-4b9yA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bqm GLUTAMINASE LIVER
ISOFORM,
MITOCHONDRIAL

(Homo sapiens) 		PF04960
(Glutaminase) 		5 VAL A 274
LEU A 422
LEU A 224
SER A 229
LEU A 367
 None
 1.15A 5hnwB-4bqmA:
undetectable		 5hnwB-4bqmA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cke MRNA-CAPPING ENZYME
REGULATORY SUBUNIT

(Vaccinia virus) 		PF03341
(Pox_mRNA-cap) 		6 ASP B 192
HIS B 260
LEU B 263
SER B 188
LEU B  61
THR B  58
 None
 1.45A 5hnwB-4ckeB:
undetectable		 5hnwB-4ckeB:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4emi TODA

(Pseudomonas
putida) 		PF07992
(Pyr_redox_2)
PF14759
(Reductase_C) 		5 VAL A 367
LEU A 198
HIS A 326
LEU A 195
THR A 196
 None
 1.04A 5hnwB-4emiA:
undetectable		 5hnwB-4emiA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fml VSDC

(Aeromonas
hydrophila) 		PF03496
(ADPrib_exo_Tox) 		5 ASP A 182
GLU A 213
LEU A 224
LEU A 191
THR A 222
 None
 1.14A 5hnwB-4fmlA:
undetectable		 5hnwB-4fmlA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gip FUSION GLYCOPROTEIN
F1
FUSION GLYCOPROTEIN
F2

(Mammalian
rubulavirus 5) 		PF00523
(Fusion_gly) 		5 VAL D 402
LEU D 305
LEU A  25
LEU D 289
THR D 307
 None
 1.20A 5hnwB-4gipD:
undetectable		 5hnwB-4gipD:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igl YENC2

(Yersinia
entomophaga) 		no annotation 5 ASP B 391
LEU B 487
LEU B 660
LEU B 479
THR B 489
 None
 1.18A 5hnwB-4iglB:
undetectable		 5hnwB-4iglB:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iq4 NON-HAEM
BROMOPEROXIDASE
BPO-A2, MATRIX
PROTEIN 1

(Influenza A
virus;
Kitasatospora
aureofaciens) 		PF00561
(Abhydrolase_1)
PF00598
(Flu_M1) 		5 VAL A 104
LEU A  46
PHE A 274
LEU A 275
ARG A  52
 None
 1.11A 5hnwB-4iq4A:
4.0		 5hnwB-4iq4A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7q PHOSPHATIDYLINOSITOL
TRANSFER PROTEIN
PDR16

(Saccharomyces
cerevisiae) 		PF00650
(CRAL_TRIO)
PF03765
(CRAL_TRIO_N) 		5 VAL A 136
LEU A 160
HIS A 176
LEU A 158
ARG A 164
 None
 0.89A 5hnwB-4j7qA:
undetectable		 5hnwB-4j7qA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7q PHOSPHATIDYLINOSITOL
TRANSFER PROTEIN
PDR16

(Saccharomyces
cerevisiae) 		PF00650
(CRAL_TRIO)
PF03765
(CRAL_TRIO_N) 		5 VAL A 136
LEU A 160
HIS A 176
LEU A 177
ARG A 164
 None
None
None
B7N  A 401 (-4.3A)
None
 1.19A 5hnwB-4j7qA:
undetectable		 5hnwB-4j7qA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7e BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana) 		no annotation 5 VAL D  62
LEU D 118
LEU D  97
LEU D 115
THR D 116
 None
 1.00A 5hnwB-4m7eD:
undetectable		 5hnwB-4m7eD:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nf1 ACETYLGLUTAMATE
KINASE

(Xylella
fastidiosa) 		PF04768
(NAT) 		5 VAL A 334
LEU A 436
LEU A 319
THR A 318
ARG A 316
 None
NLG  A 501 ( 4.7A)
None
None
None
 1.08A 5hnwB-4nf1A:
undetectable		 5hnwB-4nf1A:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pel PENICILLIN G ACYLASE
SUBUNIT BETA

(Kluyvera
cryocrescens) 		PF01804
(Penicil_amidase) 		5 VAL B 543
ASP B 542
HIS B  38
LEU B  37
LEU B  55
 None
 1.04A 5hnwB-4pelB:
undetectable		 5hnwB-4pelB:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4per ANGIOGENIN
RIBONUCLEASE
INHIBITOR

(Gallus gallus) 		PF00074
(RnaseA)
PF13516
(LRR_6) 		5 VAL A 438
ASP A 439
LEU A 413
LEU A 400
ARG B  41
 None
 0.98A 5hnwB-4perA:
undetectable		 5hnwB-4perA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4piv FATTY ACID SYNTHASE

(Homo sapiens) 		PF08242
(Methyltransf_12)
PF08659
(KR) 		5 LEU A1386
LEU A1336
LEU A1342
ARG A1383
PRO A1299
 None
 1.18A 5hnwB-4pivA:
5.7		 5hnwB-4pivA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tu3 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 74

(Saccharomyces
cerevisiae) 		PF05719
(GPP34) 		5 GLU A  72
LEU A 272
LEU A 228
LEU A 269
THR A 270
 None
 0.99A 5hnwB-4tu3A:
undetectable		 5hnwB-4tu3A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uer EIF3A

(Lachancea
kluyveri) 		no annotation 5 ASP a 338
GLU a 339
LEU a 330
LEU a 424
LEU a 387
 None
 1.19A 5hnwB-4uera:
undetectable		 5hnwB-4uera:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v2d FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 2

(Homo sapiens) 		PF01463
(LRRCT)
PF13855
(LRR_8) 		5 VAL A  47
LEU A 114
LEU A  95
LEU A 107
ARG A 112
 None
 1.09A 5hnwB-4v2dA:
undetectable		 5hnwB-4v2dA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wis LIPID SCRAMBLASE

([Nectria]
haematococca) 		PF04547
(Anoctamin) 		5 VAL A 500
ASP A 499
LEU A 565
SER A 184
THR A 563
 None
 0.98A 5hnwB-4wisA:
undetectable		 5hnwB-4wisA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgc ORIGIN RECOGNITION
COMPLEX SUBUNIT 4

(Drosophila
melanogaster) 		PF13191
(AAA_16)
PF14629
(ORC4_C) 		5 LEU D  70
LEU D 178
SER D 168
LEU D  40
PRO D 174
 None
 1.10A 5hnwB-4xgcD:
undetectable		 5hnwB-4xgcD:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysw XANTHINE
DEHYDROGENASE/OXIDAS
E

(Rattus
norvegicus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 VAL A 329
LEU A 403
LEU A 371
THR A 372
PRO A 409
 None
FAD  A3004 (-4.7A)
None
None
None
 1.03A 5hnwB-4yswA:
undetectable		 5hnwB-4yswA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zu2 PUTATIVE
ISOHEXENYLGLUTACONYL
-COA HYDRATASE

(Pseudomonas
aeruginosa) 		PF00378
(ECH_1) 		5 VAL A 123
LEU A   9
PHE A  64
LEU A  22
THR A  21
 None
 1.20A 5hnwB-4zu2A:
undetectable		 5hnwB-4zu2A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c5s UNCONVENTIONAL
MYOSIN-IXB

(Homo sapiens) 		PF00620
(RhoGAP) 		5 VAL A 251
LEU A 135
HIS A 247
PHE A 269
LEU A 194
 None
 1.12A 5hnwB-5c5sA:
undetectable		 5hnwB-5c5sA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyr RNA-DEPENDENT RNA
POLYMERASE

(Thosea asigna
virus) 		no annotation 5 VAL B 293
SER B 297
PHE B 446
LEU B 436
ARG B 429
 None
 1.04A 5hnwB-5cyrB:
undetectable		 5hnwB-5cyrB:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g0q BETA-GLUCURONIDASE

(Acidobacterium
capsulatum) 		PF03662
(Glyco_hydro_79n) 		5 VAL A 453
GLU A 451
LEU A 370
LEU A 379
THR A 380
 None
 0.95A 5hnwB-5g0qA:
2.6		 5hnwB-5g0qA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijb TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B CHIMERA

(Eptatretus
burgeri;
Mus musculus) 		PF00560
(LRR_1)
PF11921
(DUF3439)
PF13855
(LRR_8) 		5 GLU A 141
LEU A 227
LEU A 197
PHE A 170
LEU A 205
 None
 1.20A 5hnwB-5ijbA:
undetectable		 5hnwB-5ijbA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ja1 ENTEROBACTIN
SYNTHASE COMPONENT F

(Escherichia
coli) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C) 		5 VAL A 293
LEU A 382
LEU A 349
LEU A 253
THR A 249
 None
 1.14A 5hnwB-5ja1A:
undetectable		 5hnwB-5ja1A:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3r CELL DIVISION
PROTEIN FTSY
HOMOLOG,
CHLOROPLASTIC
SIGNAL RECOGNITION
PARTICLE 54 KDA
PROTEIN,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		5 ASP B 108
LEU A 325
SER A 120
LEU A 322
THR A 323
 None
None
None
None
GCP  A 401 ( 4.8A)
 1.07A 5hnwB-5l3rB:
undetectable		 5hnwB-5l3rB:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3s SIGNAL RECOGNITION
PARTICLE RECEPTOR
FTSY

(Sulfolobus
acidocaldarius) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		5 VAL B 115
GLU B 114
LEU B 319
LEU B 334
LEU B 293
 None
 1.14A 5hnwB-5l3sB:
undetectable		 5hnwB-5l3sB:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldt MOMP PORIN

(Campylobacter
jejuni) 		PF05538
(Campylo_MOMP) 		5 VAL A 339
GLU A 358
LEU A 255
LEU A 310
ARG A 316
 None
 1.05A 5hnwB-5ldtA:
undetectable		 5hnwB-5ldtA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5loi RAD26

(Thermothelomyces
thermophila) 		PF12331
(DUF3636) 		5 ASP A 499
LEU A 492
SER A 569
ARG A 511
PRO A 573
 None
 1.17A 5hnwB-5loiA:
undetectable		 5hnwB-5loiA:
21.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mjs TUBULIN BETA CHAIN

(Schizosaccharomyces
pombe) 		no annotation 6 ASP A  26
GLU A  27
LEU A 215
HIS A 227
LEU A 228
PRO A 357
 None
 1.08A 5hnwB-5mjsA:
54.3		 5hnwB-5mjsA:
58.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mjs TUBULIN BETA CHAIN

(Schizosaccharomyces
pombe) 		no annotation 5 GLU A  27
LEU A 215
LEU A 228
LEU A 272
PRO A 357
 None
 1.02A 5hnwB-5mjsA:
54.3		 5hnwB-5mjsA:
58.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpd 26S PROTEASOME
REGULATORY SUBUNIT
RPN6

(Saccharomyces
cerevisiae) 		PF01399
(PCI) 		5 VAL Q 278
ASP Q 277
LEU Q 342
LEU Q 338
THR Q 341
 None
 1.00A 5hnwB-5mpdQ:
undetectable		 5hnwB-5mpdQ:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mz9 -

(-) 		no annotation 5 ASP A 731
LEU A 159
LEU A 269
THR A 158
PRO A 720
 None
 1.16A 5hnwB-5mz9A:
undetectable		 5hnwB-5mz9A:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 6 VAL B  23
ASP B  26
GLU B  27
HIS B 229
SER B 236
THR B 276
 None
 1.14A 5hnwB-5n5nB:
54.6		 5hnwB-5n5nB:
97.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 7 VAL B  23
ASP B  26
GLU B  27
LEU B 217
HIS B 229
LEU B 230
THR B 276
 None
 1.24A 5hnwB-5n5nB:
54.6		 5hnwB-5n5nB:
97.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 7 VAL B  23
GLU B  27
HIS B 229
SER B 236
PHE B 272
THR B 276
PRO B 360
 None
 0.92A 5hnwB-5n5nB:
54.6		 5hnwB-5n5nB:
97.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 8 VAL B  23
GLU B  27
LEU B 217
HIS B 229
LEU B 230
PHE B 272
THR B 276
PRO B 360
 None
 1.02A 5hnwB-5n5nB:
54.6		 5hnwB-5n5nB:
97.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 8 VAL B  23
LEU B 217
HIS B 229
LEU B 230
PHE B 272
LEU B 275
THR B 276
PRO B 360
 None
 0.95A 5hnwB-5n5nB:
54.6		 5hnwB-5n5nB:
97.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oon UNDECAPRENYL-DIPHOSP
HATASE

(Escherichia
coli) 		no annotation 5 LEU A  71
LEU A 198
PHE A 195
LEU A  90
THR A  91
 None
 1.09A 5hnwB-5oonA:
undetectable		 5hnwB-5oonA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oyn DEHYDRATASE,
ILVD/EDD FAMILY

(Caulobacter
vibrioides) 		no annotation 5 VAL A  71
LEU A 114
LEU A 124
LEU A 110
THR A 113
 None
 1.18A 5hnwB-5oynA:
undetectable		 5hnwB-5oynA:
10.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ucy TUBULIN ALPHA CHAIN

(Tetrahymena
thermophila) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		5 GLU A  27
LEU A 217
LEU A 230
SER A 236
PRO A 360
 None
 0.95A 5hnwB-5ucyA:
49.9		 5hnwB-5ucyA:
41.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w3f TUBULIN ALPHA-1
CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		5 GLU A  27
LEU A 218
LEU A 231
SER A 237
PRO A 361
 None
 0.98A 5hnwB-5w3fA:
54.9		 5hnwB-5w3fA:
42.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w3j TUBULIN BETA CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		6 VAL B  23
ASP B  26
GLU B  27
LEU B 215
THR B 274
PRO B 358
 TA1  B 502 (-3.9A)
TA1  B 502 (-4.1A)
TA1  B 502 (-3.6A)
None
TA1  B 502 (-4.7A)
None
 0.59A 5hnwB-5w3jB:
54.1		 5hnwB-5w3jB:
75.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w3j TUBULIN BETA CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		6 VAL B  23
ASP B  26
GLU B  27
LEU B 228
THR B 274
PRO B 358
 TA1  B 502 (-3.9A)
TA1  B 502 (-4.1A)
TA1  B 502 (-3.6A)
None
TA1  B 502 (-4.7A)
None
 0.79A 5hnwB-5w3jB:
54.1		 5hnwB-5w3jB:
75.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w3j TUBULIN BETA CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		5 VAL B  23
ASP B  26
GLU B  27
SER B 234
PRO B 358
 TA1  B 502 (-3.9A)
TA1  B 502 (-4.1A)
TA1  B 502 (-3.6A)
TA1  B 502 ( 4.9A)
None
 0.92A 5hnwB-5w3jB:
54.1		 5hnwB-5w3jB:
75.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wt4 CYSTEINE DESULFURASE
ISCS

(Helicobacter
pylori) 		no annotation 5 VAL A 107
LEU A 216
SER A 149
LEU A 224
THR A 225
 None
 1.09A 5hnwB-5wt4A:
2.9		 5hnwB-5wt4A:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8z PENICILLIN V
ACYLASE-LIKE PROTEIN

(Shewanella
loihica) 		no annotation 5 VAL A 127
GLU A 126
LEU A  14
LEU A 283
THR A  12
 None
 1.19A 5hnwB-5x8zA:
undetectable		 5hnwB-5x8zA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6brd RIFAMPIN
MONOOXYGENASE

(Streptomyces
venezuelae) 		no annotation 5 VAL A 132
LEU A  16
PHE A 273
LEU A 300
ARG A  21
 None
 1.03A 5hnwB-6brdA:
undetectable		 5hnwB-6brdA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ch3 FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA

(Salmonella
enterica) 		no annotation 5 HIS A 538
LEU A 541
PHE A 400
LEU A 545
PRO A 403
 None
 1.20A 5hnwB-6ch3A:
undetectable		 5hnwB-6ch3A:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f9m SERINE PROTEASE

(Planococcus
plakortidis) 		no annotation 5 VAL A 150
LEU A 306
SER A 152
LEU A 304
THR A 289
 None
 1.15A 5hnwB-6f9mA:
undetectable		 5hnwB-6f9mA:
10.27