SIMILAR PATTERNS OF AMINO ACIDS FOR 5HM8_G_ADNG501_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dlc DELTA-ENDOTOXIN
CRYIIIA

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		4 GLU A 639
THR A 510
GLU A 298
LEU A 282
 None
 1.25A 5hm8G-1dlcA:
undetectable		 5hm8G-1dlcA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ji6 PESTICIDIAL CRYSTAL
PROTEIN CRY3BB

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		4 GLU A 646
THR A 513
GLU A 299
LEU A 283
 None
 1.22A 5hm8G-1ji6A:
undetectable		 5hm8G-1ji6A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k26 NUDIX HOMOLOG

(Pyrobaculum
aerophilum) 		PF00293
(NUDIX) 		4 THR A   4
GLU A  49
THR A  50
LEU A   8
 None
GOL  A 211 (-3.7A)
None
None
 1.23A 5hm8G-1k26A:
undetectable		 5hm8G-1k26A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oru YUAD PROTEIN

(Bacillus
subtilis) 		no annotation 4 GLU A  10
GLU A  89
THR A  22
LEU A  28
 None
 1.25A 5hm8G-1oruA:
undetectable		 5hm8G-1oruA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1svd RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE/OXYGENAS
E LARGE SUBUNIT

(Halothiobacillus
neapolitanus) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 GLU A 252
GLU A 219
THR A 218
LEU A 233
 None
 1.27A 5hm8G-1svdA:
undetectable		 5hm8G-1svdA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ua4 ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
furiosus) 		PF04587
(ADP_PFK_GK) 		4 GLU A 352
THR A 351
THR A 454
LEU A 228
 None
 1.26A 5hm8G-1ua4A:
3.9		 5hm8G-1ua4A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v72 ALDOLASE

(Pseudomonas
putida) 		PF01212
(Beta_elim_lyase) 		4 GLU A 132
THR A 130
THR A  80
LEU A 111
 None
 1.01A 5hm8G-1v72A:
undetectable		 5hm8G-1v72A:
20.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1v8b ADENOSYLHOMOCYSTEINA
SE

(Plasmodium
falciparum) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 GLU A  58
GLU A 200
THR A 201
LEU A 389
 ADN  A 502 (-3.6A)
ADN  A 502 (-4.0A)
NAD  A 501 ( 2.8A)
NAD  A 501 ( 3.8A)
 0.45A 5hm8G-1v8bA:
55.9		 5hm8G-1v8bA:
52.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w4i PYRUVATE
DEHYDROGENASE E2

(Pyrobaculum
aerophilum) 		PF02817
(E3_binding) 		4 GLU A 161
GLU A 169
THR A 170
LEU A 142
 None
 1.22A 5hm8G-1w4iA:
undetectable		 5hm8G-1w4iA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x5r GLUTAMATE RECEPTOR
INTERACTING PROTEIN
2

(Homo sapiens) 		PF00595
(PDZ) 		4 GLU A  79
THR A  78
GLU A 102
THR A  17
 None
 1.19A 5hm8G-1x5rA:
undetectable		 5hm8G-1x5rA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ytu HYPOTHETICAL PROTEIN
AF1318

(Archaeoglobus
fulgidus) 		PF02171
(Piwi) 		4 GLU A 264
THR A 265
THR A 250
LEU A 292
 None
 1.12A 5hm8G-1ytuA:
undetectable		 5hm8G-1ytuA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yvd RAS-RELATED PROTEIN
RAB-22A

(Mus musculus) 		PF00071
(Ras) 		4 GLU A 127
THR A  88
GLU A 146
LEU A  96
 None
 1.23A 5hm8G-1yvdA:
2.1		 5hm8G-1yvdA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z0a RAS-RELATED PROTEIN
RAB-2A

(Homo sapiens) 		PF00071
(Ras) 		4 GLU A 128
THR A  89
GLU A 147
LEU A  97
 None
 1.27A 5hm8G-1z0aA:
undetectable		 5hm8G-1z0aA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3

(Thermoplasma
acidophilum) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 GLU A 694
THR A 695
THR A 633
LEU A 639
 None
 1.26A 5hm8G-1z1wA:
undetectable		 5hm8G-1z1wA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fe0 SMALL MYRISTOYLATED
PROTEIN 1

(Leishmania
major) 		PF09149
(DUF1935) 		4 GLU A 121
GLU A  97
THR A  98
LEU A  37
 None
 1.15A 5hm8G-2fe0A:
undetectable		 5hm8G-2fe0A:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fjk FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Thermus
caldophilus) 		PF01116
(F_bP_aldolase) 		4 GLU A 114
THR A 115
GLU A 120
LEU A  92
 None
 1.28A 5hm8G-2fjkA:
2.4		 5hm8G-2fjkA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hpg ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF03480
(DctP) 		4 GLU A 265
GLU A 246
THR A  87
LEU A 139
 None
 1.11A 5hm8G-2hpgA:
undetectable		 5hm8G-2hpgA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lc0 PUTATIVE
UNCHARACTERIZED
PROTEIN TB39.8

(Mycobacterium
tuberculosis) 		PF12401
(DUF3662) 		4 GLU A 130
THR A 131
GLU A  61
THR A 124
 None
 1.13A 5hm8G-2lc0A:
2.4		 5hm8G-2lc0A:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pq7 PREDICTED HD
SUPERFAMILY
HYDROLASE

(uncultured
Thermotogales
bacterium) 		PF01966
(HD) 		4 GLU A 187
GLU A 192
THR A 193
LEU A 133
 None
 1.25A 5hm8G-2pq7A:
undetectable		 5hm8G-2pq7A:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qua EXTRACELLULAR LIPASE

(Serratia
marcescens) 		no annotation 4 THR A 524
GLU A 427
THR A 426
LEU A 435
 None
 1.02A 5hm8G-2quaA:
undetectable		 5hm8G-2quaA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wmo DEDICATOR OF
CYTOKINESIS PROTEIN
9

(Homo sapiens) 		PF06920
(DHR-2) 		4 GLU A 143
THR A 142
GLU A 105
LEU A 134
 None
 1.12A 5hm8G-2wmoA:
undetectable		 5hm8G-2wmoA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ygk NURA

(Sulfolobus
solfataricus) 		PF09376
(NurA) 		4 GLU A 225
THR A 224
GLU A 221
LEU A 263
 None
 1.03A 5hm8G-2ygkA:
undetectable		 5hm8G-2ygkA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yia RNA-DIRECTED RNA
POLYMERASE

(Infectious
pancreatic
necrosis virus) 		PF04197
(Birna_RdRp) 		4 THR A 739
GLU A 784
THR A 785
LEU A 274
 None
 1.10A 5hm8G-2yiaA:
undetectable		 5hm8G-2yiaA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yv2 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN

(Aeropyrum
pernix) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		4 GLU A  13
THR A  14
THR A 124
LEU A 200
 None
 1.14A 5hm8G-2yv2A:
3.4		 5hm8G-2yv2A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yyh 8-OXO-DGTPASE DOMAIN

(Aquifex
aeolicus) 		PF00293
(NUDIX) 		4 THR A  64
GLU A  59
THR A  12
LEU A  70
 None
 1.07A 5hm8G-2yyhA:
undetectable		 5hm8G-2yyhA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0f XYLOGLUCANASE

(Geotrichum sp.
M128) 		no annotation 4 GLU A 435
THR A 437
THR A 406
LEU A 374
 None
 1.00A 5hm8G-3a0fA:
undetectable		 5hm8G-3a0fA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2f DNA POLYMERASE

(Pyrococcus
furiosus) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 GLU A 659
GLU A 622
THR A 623
LEU A 651
 None
 1.27A 5hm8G-3a2fA:
undetectable		 5hm8G-3a2fA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3axs PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1

(Aquifex
aeolicus) 		PF02005
(TRM) 		4 GLU A  73
THR A  74
GLU A 296
LEU A  38
 None
 1.21A 5hm8G-3axsA:
4.4		 5hm8G-3axsA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bz6 UPF0502 PROTEIN
PSPTO_2686

(Pseudomonas
syringae group
genomosp. 3) 		PF04337
(DUF480) 		4 GLU A  77
GLU A  23
THR A  22
LEU A  48
 None
 1.27A 5hm8G-3bz6A:
undetectable		 5hm8G-3bz6A:
18.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ce6 ADENOSYLHOMOCYSTEINA
SE

(Mycobacterium
tuberculosis) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 THR A  74
GLU A 218
THR A 219
LEU A 407
 ADN  A 500 (-4.5A)
ADN  A 500 (-2.6A)
NAD  A 550 ( 2.8A)
NAD  A 550 (-4.2A)
 0.93A 5hm8G-3ce6A:
53.6		 5hm8G-3ce6A:
49.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eo8 BLUB-LIKE
FLAVOPROTEIN

(Clostridioides
difficile) 		PF00881
(Nitroreductase) 		4 GLU A  57
GLU A 179
THR A 180
LEU A 104
 None
 1.24A 5hm8G-3eo8A:
undetectable		 5hm8G-3eo8A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f8r THIOREDOXIN
REDUCTASE (TRXB-3)

(Sulfolobus
solfataricus) 		PF07992
(Pyr_redox_2) 		4 GLU A 101
GLU A 111
THR A 106
LEU A  42
 None
 1.13A 5hm8G-3f8rA:
4.6		 5hm8G-3f8rA:
22.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g1u ADENOSYLHOMOCYSTEINA
SE

(Leishmania
major) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 THR A  57
GLU A 155
THR A 156
LEU A 343
 ADN  A 438 (-4.6A)
ADN  A 438 (-3.8A)
NAD  A 439 ( 3.0A)
NAD  A 439 ( 4.0A)
 0.77A 5hm8G-3g1uA:
50.8		 5hm8G-3g1uA:
50.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3glq ADENOSYLHOMOCYSTEINA
SE

(Burkholderia
pseudomallei) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 THR A  67
GLU A 199
THR A 200
LEU A 385
 RAB  A 602 (-4.5A)
RAB  A 602 (-4.6A)
NAD  A 601 ( 2.9A)
NAD  A 601 ( 4.1A)
 0.78A 5hm8G-3glqA:
55.0		 5hm8G-3glqA:
50.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3h9u ADENOSYLHOMOCYSTEINA
SE

(Trypanosoma
brucei) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 THR A  57
GLU A 155
THR A 156
LEU A 343
 ADN  A 439 (-4.7A)
None
NAD  A 438 (-3.8A)
NAD  A 438 (-4.0A)
 0.68A 5hm8G-3h9uA:
52.9		 5hm8G-3h9uA:
51.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hq2 BACILLUS SUBTILIS
M32 CARBOXYPEPTIDASE

(Bacillus
subtilis) 		PF02074
(Peptidase_M32) 		4 GLU A 273
THR A 238
GLU A 266
THR A 263
 None
None
PO4  A 503 (-3.0A)
None
 1.21A 5hm8G-3hq2A:
undetectable		 5hm8G-3hq2A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ixw HEMOCYANIN AA6 CHAIN

(Androctonus
australis) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 GLU A 436
GLU A 537
THR A 507
LEU A 483
 None
 1.24A 5hm8G-3ixwA:
2.8		 5hm8G-3ixwA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k6g TELOMERIC
REPEAT-BINDING
FACTOR 2
TELOMERIC
REPEAT-BINDING
FACTOR 2-INTERACTING
PROTEIN 1

(Homo sapiens) 		PF11626
(Rap1_C)
PF16772
(TERF2_RBM) 		4 GLU A 395
GLU A 342
THR A 346
LEU D 288
 None
 1.08A 5hm8G-3k6gA:
undetectable		 5hm8G-3k6gA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9t PUTATIVE PEPTIDASE

(Clostridium
acetobutylicum) 		PF09940
(DUF2172)
PF16221
(HTH_47)
PF16254
(DUF4910) 		4 GLU A 353
GLU A 347
THR A 344
LEU A 248
 None
MRD  A 439 ( 4.8A)
None
None
 1.21A 5hm8G-3k9tA:
undetectable		 5hm8G-3k9tA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mln TRANSCRIPTION FACTOR
COE1

(Mus musculus) 		PF16422
(COE1_DBD) 		4 GLU A 123
THR A 122
GLU A  85
LEU A 188
 None
 1.28A 5hm8G-3mlnA:
undetectable		 5hm8G-3mlnA:
17.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n58 ADENOSYLHOMOCYSTEINA
SE

(Brucella
abortus) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 THR A  60
GLU A 192
THR A 193
LEU A 378
 ADN  A 500 (-4.6A)
ADN  A 500 (-3.6A)
NAD  A 550 ( 3.0A)
NAD  A 550 (-4.3A)
 0.68A 5hm8G-3n58A:
55.0		 5hm8G-3n58A:
52.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3now UNC-45 PROTEIN,
SD10334P

(Drosophila
melanogaster) 		PF11701
(UNC45-central) 		4 GLU A 198
THR A 195
THR A 248
LEU A 169
 None
 1.00A 5hm8G-3nowA:
undetectable		 5hm8G-3nowA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nsj PERFORIN-1

(Mus musculus) 		PF00168
(C2)
PF01823
(MACPF) 		4 GLU A 174
THR A 172
GLU A 119
LEU A  52
 None
 1.25A 5hm8G-3nsjA:
undetectable		 5hm8G-3nsjA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odw RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1

(Homo sapiens) 		PF00621
(RhoGEF) 		4 GLU A 581
THR A 579
GLU A 589
LEU A 497
 None
 1.17A 5hm8G-3odwA:
undetectable		 5hm8G-3odwA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odx RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1

(Homo sapiens) 		PF00621
(RhoGEF) 		4 GLU A 581
THR A 579
GLU A 589
LEU A 497
 None
 1.15A 5hm8G-3odxA:
undetectable		 5hm8G-3odxA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogk CORONATINE-INSENSITI
VE PROTEIN 1

(Arabidopsis
thaliana) 		no annotation 4 GLU B 234
GLU B 213
THR B 214
LEU B 184
 None
 1.11A 5hm8G-3ogkB:
undetectable		 5hm8G-3ogkB:
21.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3one ADENOSYLHOMOCYSTEINA
SE

(Lupinus luteus) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 THR A  67
GLU A 205
THR A 206
LEU A 395
 ADE  A 506 (-4.5A)
None
NAD  A 501 (-2.8A)
NAD  A 501 (-4.2A)
 0.53A 5hm8G-3oneA:
54.8		 5hm8G-3oneA:
55.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oth CALG1

(Micromonospora
echinospora) 		PF00201
(UDPGT)
PF03033
(Glyco_transf_28) 		4 GLU A 117
THR A  14
THR A  32
LEU A 102
 None
 1.10A 5hm8G-3othA:
3.4		 5hm8G-3othA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3thw DNA MISMATCH REPAIR
PROTEIN MSH3

(Homo sapiens) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05192
(MutS_III) 		4 GLU B 302
THR B 301
GLU B 242
LEU B 223
 None
 1.04A 5hm8G-3thwB:
2.2		 5hm8G-3thwB:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr5 PEPTIDE CHAIN
RELEASE FACTOR 3

(Coxiella
burnetii) 		PF00009
(GTP_EFTU)
PF16658
(RF3_C) 		4 GLU A 521
THR A 522
GLU A  94
LEU A 123
 None
 0.95A 5hm8G-3tr5A:
undetectable		 5hm8G-3tr5A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u1t DMMA HALOALKANE
DEHALOGENASE

(unidentified) 		PF00561
(Abhydrolase_1) 		4 GLU A 168
THR A 314
THR A 213
LEU A 190
 None
MLI  A 351 (-4.0A)
None
None
 1.06A 5hm8G-3u1tA:
undetectable		 5hm8G-3u1tA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u7z PUTATIVE METAL
BINDING PROTEIN
RUMGNA_00854

([Ruminococcus]
gnavus) 		PF14478
(DUF4430) 		4 GLU A  50
THR A  49
GLU A  89
LEU A  71
 None
 1.27A 5hm8G-3u7zA:
undetectable		 5hm8G-3u7zA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vov GLUCOKINASE

(Thermus
thermophilus) 		PF00480
(ROK) 		4 GLU A  53
GLU A  48
THR A  98
LEU A   6
 None
 0.92A 5hm8G-3vovA:
undetectable		 5hm8G-3vovA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vz0 PUTATIVE
NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Gluconobacter
oxydans) 		PF00171
(Aldedh) 		4 GLU A  74
GLU A  85
THR A  89
LEU A 171
 None
 1.13A 5hm8G-3vz0A:
3.9		 5hm8G-3vz0A:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ade SUCCINYLORNITHINE
TRANSAMINASE

(Escherichia
coli) 		PF00202
(Aminotran_3) 		4 GLU A 234
GLU A 224
THR A 250
LEU A 296
 None
 1.15A 5hm8G-4adeA:
undetectable		 5hm8G-4adeA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayg GLUCANSUCRASE

(Lactobacillus
reuteri) 		PF01473
(CW_binding_1)
PF02324
(Glyco_hydro_70) 		4 GLU A 841
GLU A 812
THR A 822
LEU A1620
 None
 1.14A 5hm8G-4aygA:
2.2		 5hm8G-4aygA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1n CARBON MONOXIDE
DEHYDROGENASE
CORRINOID/IRON-SULFU
R PROTEIN, GAMMA
SUBUNIT

(Carboxydothermus
hydrogenoformans) 		PF03599
(CdhD)
PF04060
(FeS) 		4 GLU A 165
GLU A 172
THR A 173
LEU A 160
 None
 1.15A 5hm8G-4c1nA:
undetectable		 5hm8G-4c1nA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4evw NUCLEOSIDE-DIPHOSPHA
TE-SUGAR
PYROPHOSPHORYLASE

(Vibrio cholerae) 		no annotation 4 GLU A 202
GLU A  89
THR A  92
LEU A 208
 None
 1.23A 5hm8G-4evwA:
undetectable		 5hm8G-4evwA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fml VSDC

(Aeromonas
hydrophila) 		PF03496
(ADPrib_exo_Tox) 		4 GLU A 173
THR A 222
GLU A 131
LEU A 204
 None
 1.24A 5hm8G-4fmlA:
undetectable		 5hm8G-4fmlA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLU A 215
THR A 212
THR A 122
LEU A 154
 None
 1.23A 5hm8G-4fr4A:
undetectable		 5hm8G-4fr4A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h62 MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 11
MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 22

(Saccharomyces
cerevisiae) 		no annotation 4 GLU V 106
GLU V 113
THR V 114
LEU K 105
 None
 1.19A 5hm8G-4h62V:
undetectable		 5hm8G-4h62V:
6.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iqz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA'

(Escherichia
coli) 		no annotation 4 GLU A  82
GLU A  70
THR A  69
LEU A  92
 None
IOD  A 309 (-3.7A)
None
None
 1.00A 5hm8G-4iqzA:
undetectable		 5hm8G-4iqzA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j57 THIOREDOXIN
REDUCTASE 2

(Plasmodium
falciparum) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 THR A 486
GLU A 402
THR A 399
LEU A 257
 None
 1.24A 5hm8G-4j57A:
undetectable		 5hm8G-4j57A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6j WINGS APART-LIKE
PROTEIN HOMOLOG

(Homo sapiens) 		PF07814
(WAPL) 		4 GLU A 852
GLU A 859
THR A 862
LEU A 880
 None
 1.26A 5hm8G-4k6jA:
undetectable		 5hm8G-4k6jA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kq7 HYPOTHETICAL PROTEIN

(Bacteroides
uniformis) 		PF11175
(DUF2961) 		4 GLU A 222
THR A 221
GLU A 228
THR A 229
 None
 1.28A 5hm8G-4kq7A:
undetectable		 5hm8G-4kq7A:
21.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lvc S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE)

(Bradyrhizobium
elkanii) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 THR A  63
GLU A 197
THR A 198
LEU A 383
 ADN  A 501 (-4.5A)
ADN  A 501 (-3.6A)
NAD  A 503 ( 2.9A)
NAD  A 503 ( 3.9A)
 0.50A 5hm8G-4lvcA:
54.6		 5hm8G-4lvcA:
51.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ndk E23P-YFP, GFP-LIKE
FLUORESCENT
CHROMOPROTEIN FP506,
RELATED, CHIMERIC
CONSTRUCT,

(Aequorea
victoria;
Eimeria
acervulina) 		PF00046
(Homeobox)
PF01353
(GFP) 		4 GLU A  70
GLU A 177
THR A 161
LEU A 113
 None
 1.26A 5hm8G-4ndkA:
undetectable		 5hm8G-4ndkA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nq8 PUTATIVE PERIPLASMIC
SUBSTRATE-BINDING
TRANSPORT PROTEIN

(Bordetella
bronchiseptica) 		PF03480
(DctP) 		4 GLU A 172
THR A 171
THR A 101
LEU A 237
 None
PAF  A 401 (-4.5A)
None
None
 1.12A 5hm8G-4nq8A:
undetectable		 5hm8G-4nq8A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9x TCDB2, TCCC3

(Photorhabdus
luminescens) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		4 GLU A2060
GLU A1798
THR A1806
LEU A1817
 None
 1.24A 5hm8G-4o9xA:
undetectable		 5hm8G-4o9xA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4up5 PYGOPUS HOMOLOG 2,
B-CELL CLL/LYMPHOMA
9-LIKE PROTEIN

(Homo sapiens) 		PF00628
(PHD) 		4 GLU A 372
THR A 371
THR A 362
LEU A1251
 None
 1.02A 5hm8G-4up5A:
undetectable		 5hm8G-4up5A:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y25 POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
EXPORT PROTEIN

(Escherichia
coli) 		no annotation 4 GLU A 678
THR A 668
GLU A 627
LEU A 635
 None
 1.14A 5hm8G-4y25A:
undetectable		 5hm8G-4y25A:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ye5 PEPTIDOGLYCAN
SYNTHETASE
PENICILLIN-BINDING
PROTEIN 3

(Bifidobacterium
adolescentis) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		4 GLU A 299
THR A 298
GLU A 262
LEU A  77
 None
 1.29A 5hm8G-4ye5A:
undetectable		 5hm8G-4ye5A:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zi6 CYTOSOL
AMINOPEPTIDASE

(Helicobacter
pylori) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		4 GLU A 312
THR A 311
GLU A 342
THR A 339
 None
None
ZN  A 501 (-2.5A)
None
 1.02A 5hm8G-4zi6A:
undetectable		 5hm8G-4zi6A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aga DNA POLYMERASE THETA

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 GLU A 332
THR A 333
THR A 488
LEU A 293
 None
 1.20A 5hm8G-5agaA:
undetectable		 5hm8G-5agaA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ehk LANTIBIOTIC
DEHYDRATASE

(Microbispora
corallina) 		PF04738
(Lant_dehydr_N)
PF14028
(Lant_dehydr_C) 		4 GLU A 482
THR A 484
THR A 686
LEU A 394
 None
 1.23A 5hm8G-5ehkA:
2.9		 5hm8G-5ehkA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fqe BETA-N-ACETYLGALACTO
SAMINIDASE

(Clostridium
perfringens) 		PF13320
(DUF4091) 		4 GLU A 172
THR A 173
GLU A 521
LEU A 165
 None
None
BR  A1589 ( 4.7A)
None
 1.15A 5hm8G-5fqeA:
2.0		 5hm8G-5fqeA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gjn LYSINE/ORNITHINE
DECARBOXYLASE

(Selenomonas
ruminantium) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		4 THR A 353
GLU A 287
THR A 269
LEU A 305
 None
 1.28A 5hm8G-5gjnA:
2.8		 5hm8G-5gjnA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m89 SPLICEOSOME WD40 SC

(Chaetomium
thermophilum) 		no annotation 4 GLU A 212
THR A 251
GLU A 249
LEU A 225
 None
 1.25A 5hm8G-5m89A:
undetectable		 5hm8G-5m89A:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n1q METHYL-COENZYME M
REDUCTASE III FROM
METHANOTHERMOCOCCUS
THERMOLITHOTROPHICUS
SUBUNIT BETA

(Methanothermococcus
thermolithotrophicus) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		4 GLU B 225
THR B 221
GLU B 219
LEU B 178
 None
 1.10A 5hm8G-5n1qB:
undetectable		 5hm8G-5n1qB:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT

(Methanotorris
formicicus) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		4 GLU B 225
THR B 221
GLU B 219
LEU B 178
 None
 1.09A 5hm8G-5n28B:
undetectable		 5hm8G-5n28B:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4w CULLIN-2

(Homo sapiens) 		PF00888
(Cullin)
PF10557
(Cullin_Nedd8) 		4 GLU A 166
GLU A 214
THR A 215
LEU A 254
 None
 1.14A 5hm8G-5n4wA:
undetectable		 5hm8G-5n4wA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nit GLUCOSE OXIDASE

(Aspergillus
niger) 		no annotation 4 THR A 104
GLU A 231
THR A 170
LEU A 569
 FAD  A 601 (-4.5A)
None
None
None
 1.20A 5hm8G-5nitA:
undetectable		 5hm8G-5nitA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o6b ATP-DEPENDENT DNA
HELICASE PIF1

(Saccharomyces
cerevisiae) 		no annotation 4 GLU A 739
GLU A 443
THR A 440
LEU A 428
 None
 1.23A 5hm8G-5o6bA:
undetectable		 5hm8G-5o6bA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5szu ACYL-COA HYDROLASE

(Neisseria
meningitidis) 		PF03061
(4HBT) 		4 GLU A 140
GLU A  89
THR A 113
LEU A 150
 None
None
None
COA  A 201 (-4.4A)
 1.20A 5hm8G-5szuA:
undetectable		 5hm8G-5szuA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5um8 GLYCOPROTEIN GP120

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		4 GLU G  49
THR G  50
GLU G 490
LEU G 226
 None
 1.04A 5hm8G-5um8G:
undetectable		 5hm8G-5um8G:
21.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5utu ADENOSYLHOMOCYSTEINA
SE

(Cryptosporidium
parvum) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 GLU A  57
THR A  58
GLU A 211
THR A 212
LEU A 401
 SAH  A 502 (-3.7A)
SAH  A 502 (-4.2A)
SAH  A 502 (-3.8A)
NAD  A 501 ( 4.1A)
NAD  A 501 (-4.1A)
 0.64A 5hm8G-5utuA:
49.9		 5hm8G-5utuA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v4b F-BOX/WD
REPEAT-CONTAINING
PROTEIN 7

(Homo sapiens) 		PF00400
(WD40)
PF12937
(F-box-like) 		4 GLU B2471
GLU B2489
THR B2490
LEU B2494
 None
 1.23A 5hm8G-5v4bB:
undetectable		 5hm8G-5v4bB:
21.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE

(Naegleria
fowleri) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 GLU A  63
THR A  64
GLU A 197
THR A 198
LEU A 386
 ADN  A 502 (-3.6A)
ADN  A 502 (-4.4A)
ADN  A 502 (-3.5A)
NAD  A 501 ( 2.9A)
NAD  A 501 (-3.9A)
 0.47A 5hm8G-5v96A:
55.4		 5hm8G-5v96A:
54.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vrb TRANSKETOLASE

(Neisseria
gonorrhoeae) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 GLU A 557
THR A 554
THR A 478
LEU A 432
 EDO  A 701 (-3.8A)
None
None
None
 1.19A 5hm8G-5vrbA:
undetectable		 5hm8G-5vrbA:
22.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w4b ADENOSYLHOMOCYSTEINA
SE

(Homo sapiens) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 GLU A  59
THR A  60
GLU A 156
THR A 157
 9W4  A 502 (-3.8A)
None
None
None
 0.83A 5hm8G-5w4bA:
44.5		 5hm8G-5w4bA:
48.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xex POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Staphylococcus
aureus) 		no annotation 4 GLU A 504
THR A 502
GLU A 198
LEU A 175
 None
 1.27A 5hm8G-5xexA:
2.5		 5hm8G-5xexA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xey PHLORETIN HYDROLASE

(Mycobacteroides
abscessus) 		no annotation 4 GLU A  62
GLU A  71
THR A  67
LEU A  90
 None
 1.23A 5hm8G-5xeyA:
undetectable		 5hm8G-5xeyA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgc RAP1 GTPASE-GDP
DISSOCIATION
STIMULATOR 1

(Homo sapiens) 		PF00514
(Arm) 		4 GLU A 239
THR A 242
GLU A 197
LEU A 179
 None
 1.07A 5hm8G-5xgcA:
undetectable		 5hm8G-5xgcA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yi4 DISRUPTED IN
SCHIZOPHRENIA 1
HOMOLOG,NUCLEAR
DISTRIBUTION PROTEIN
NUDE-LIKE 1

(Mus musculus) 		no annotation 4 GLU A  33
GLU A  54
THR A  57
LEU A 120
 None
 1.28A 5hm8G-5yi4A:
undetectable		 5hm8G-5yi4A:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ymu OUTER CAPSID PROTEIN
VP4

(Rotavirus A) 		no annotation 4 GLU A 134
THR A  33
GLU A  31
THR A  57
 None
 1.24A 5hm8G-5ymuA:
undetectable		 5hm8G-5ymuA:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ze8 CYTOCHROME C552

(Thermochromatium
tepidum) 		no annotation 4 GLU A 382
THR A 383
GLU A 385
LEU A 323
 None
 1.19A 5hm8G-5ze8A:
undetectable		 5hm8G-5ze8A:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bhu MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1

(Bos taurus) 		no annotation 4 GLU A1156
GLU A 760
THR A 759
LEU A 768
 None
 0.86A 5hm8G-6bhuA:
undetectable		 5hm8G-6bhuA:
0.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY

(Thermobifida
fusca) 		no annotation 4 GLU G 106
THR G  89
THR A 541
LEU A 421
 None
 1.23A 5hm8G-6c66G:
undetectable		 5hm8G-6c66G:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3m -

(-) 		no annotation 4 THR B  66
GLU B 164
THR B 165
LEU B 373
 ADN  B 502 (-4.6A)
ADN  B 502 (-3.6A)
NAD  B 501 ( 2.8A)
NAD  B 501 ( 3.9A)
 0.52A 5hm8G-6f3mB:
49.2		 5hm8G-6f3mB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gbn -

(-) 		no annotation 4 THR A  61
GLU A 159
THR A 160
LEU A 347
 ADN  A 501 (-4.6A)
ADN  A 501 (-3.9A)
NAD  A 502 ( 2.8A)
NAD  A 502 (-3.9A)
 0.53A 5hm8G-6gbnA:
52.8		 5hm8G-6gbnA:
undetectable