SIMILAR PATTERNS OF AMINO ACIDS FOR 5HM8_B_ADNB501
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ak0 | P1 NUCLEASE (Penicilliumcitrinum) |
PF02265(S1-P1_nuclease) | 5 | ASP A 153ASP A 45HIS A 149GLY A 119HIS A 116 | ZN A 272 ( 2.1A) ZN A 271 (-3.2A)THS A 295 ( 3.4A)None ZN A 271 (-3.5A) | 1.35A | 5hm8B-1ak0A:undetectable | 5hm8B-1ak0A:18.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g7r | TRANSLATIONINITIATION FACTORIF2/EIF5B (Methanothermobacterthermautotrophicus) |
PF00009(GTP_EFTU)PF03144(GTP_EFTU_D2)PF11987(IF-2)PF14578(GTP_EFTU_D4) | 5 | LEU A 161ASP A 162ASP A 183MET A 147PHE A 146 | None | 1.20A | 5hm8B-1g7rA:3.1 | 5hm8B-1g7rA:22.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h3e | TYROSYL-TRNASYNTHETASE (Thermusthermophilus) |
PF00579(tRNA-synt_1b) | 5 | LEU A 269LEU A 243GLY A 242HIS A 52MET A 233 | NoneNoneNoneATP A1433 (-4.3A)None | 1.39A | 5hm8B-1h3eA:undetectable | 5hm8B-1h3eA:21.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ksp | PROTEIN (DNAPOLYMERASE I-KLENOWFRAGMENT(E.C.2.7.7.7)) (Escherichiacoli) |
PF00476(DNA_pol_A)PF01612(DNA_pol_A_exo1) | 5 | HIS A 509THR A 442GLY A 418MET A 531PHE A 526 | None | 1.47A | 5hm8B-1kspA:undetectable | 5hm8B-1kspA:22.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o2d | ALCOHOLDEHYDROGENASE,IRON-CONTAINING (Thermotogamaritima) |
PF00465(Fe-ADH) | 5 | HIS A 270THR A 263ASP A 189HIS A 193GLY A 259 | FE A 900 ( 3.4A)None FE A 900 ( 2.5A) FE A 900 ( 3.4A)None | 1.12A | 5hm8B-1o2dA:2.6 | 5hm8B-1o2dA:24.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tj7 | ARGININOSUCCINATELYASE (Escherichiacoli) |
PF00206(Lyase_1)PF14698(ASL_C2) | 5 | LEU A 103HIS A 104ASP A 33LEU A 3HIS A 85 | None | 1.47A | 5hm8B-1tj7A:undetectable | 5hm8B-1tj7A:22.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uan | HYPOTHETICAL PROTEINTT1542 (Thermusthermophilus) |
PF02585(PIG-L) | 5 | HIS A 10ASP A 13HIS A 111GLY A 43PHE A 177 | None | 1.46A | 5hm8B-1uanA:3.1 | 5hm8B-1uanA:17.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1upx | HYDROXYLAMINEREDUCTASE (Desulfovibriodesulfuricans) |
PF03063(Prismane) | 5 | THR A 216ASP A 241LYS A 342HIS A 159GLY A 164 | None | 1.49A | 5hm8B-1upxA:3.4 | 5hm8B-1upxA:24.83 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1v8b | ADENOSYLHOMOCYSTEINASE (Plasmodiumfalciparum) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 11 | LEU A 53HIS A 54THR A 56ASP A 134LYS A 230ASP A 234LEU A 392GLY A 397HIS A 398MET A 403PHE A 407 | NoneADN A 502 (-4.1A)ADN A 502 (-3.0A)ADN A 502 (-3.1A)ADN A 502 (-3.0A)ADN A 502 (-2.8A)ADN A 502 ( 4.9A)ADN A 502 ( 3.7A)ADN A 502 ( 3.5A)ADN A 502 (-3.6A)None | 0.21A | 5hm8B-1v8bA:56.0 | 5hm8B-1v8bA:52.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vlj | NADH-DEPENDENTBUTANOLDEHYDROGENASE (Thermotogamaritima) |
PF00465(Fe-ADH) | 5 | HIS A 199ASP A 195ASP A 103HIS A 268LEU A 252 | FE A 400 ( 3.3A) FE A 400 (-2.2A)NAP A 800 (-2.9A) FE A 400 (-3.4A)NAP A 800 (-4.6A) | 1.31A | 5hm8B-1vljA:undetectable | 5hm8B-1vljA:22.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bmo | OXYGENASE-ALPHA NBDO (Comamonas sp.JS765) |
PF00355(Rieske)PF00848(Ring_hydroxyl_A) | 5 | LEU A 305THR A 326ASP A 360GLY A 351PHE A 200 | NoneNone FE A1441 ( 2.0A)NoneEDO A1442 (-3.7A) | 1.30A | 5hm8B-2bmoA:undetectable | 5hm8B-2bmoA:22.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2eh0 | KINESIN-LIKE PROTEINKIF1B (Homo sapiens) |
PF00498(FHA)PF16183(Kinesin_assoc) | 5 | LEU A 11LEU A 48GLY A 36HIS A 57PHE A 60 | None | 1.28A | 5hm8B-2eh0A:undetectable | 5hm8B-2eh0A:13.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g1l | KINESIN-LIKE PROTEINKIF1C (Homo sapiens) |
PF00498(FHA)PF16183(Kinesin_assoc) | 5 | LEU A 501LEU A 534GLY A 526HIS A 543PHE A 546 | None | 1.14A | 5hm8B-2g1lA:undetectable | 5hm8B-2g1lA:13.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hfq | HYPOTHETICAL PROTEIN (Nitrosomonaseuropaea) |
PF09630(DUF2024) | 5 | LEU A 40LYS A 80GLY A 15HIS A 16MET A 18 | None | 1.16A | 5hm8B-2hfqA:undetectable | 5hm8B-2hfqA:11.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hp3 | IDS-EPIMERASE (Agrobacteriumtumefaciens) |
PF03972(MmgE_PrpD) | 5 | LEU A 263ASP A 91LEU A 104GLY A 159MET A 96 | None | 1.30A | 5hm8B-2hp3A:undetectable | 5hm8B-2hp3A:21.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ijd | PICORNAIN 3C,RNA-DIRECTED RNAPOLYMERASE (Enterovirus C) |
PF00548(Peptidase_C3)PF00680(RdRP_1) | 5 | LEU 1 28THR 1 152GLY 1 155HIS 1 89MET 1 10 | None | 1.49A | 5hm8B-2ijd1:undetectable | 5hm8B-2ijd1:23.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2inc | TOLUENE, O-XYLENEMONOOXYGENASEOXYGENASE SUBUNIT (Pseudomonasstutzeri) |
PF02332(Phenol_Hydrox) | 5 | LEU B 250THR B 126ASP B 247HIS B 109LEU B 176 | None | 1.37A | 5hm8B-2incB:undetectable | 5hm8B-2incB:19.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ood | BLR3880 PROTEIN (Bradyrhizobiumdiazoefficiens) |
PF01979(Amidohydro_1) | 5 | HIS A 81ASP A 77HIS A 234GLY A 330PHE A 123 | ZN A 500 ( 3.3A)NoneGUN A 600 ( 2.8A)NoneNone | 1.37A | 5hm8B-2oodA:2.1 | 5hm8B-2oodA:21.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r2d | ZN-DEPENDENTHYDROLASES (Agrobacteriumfabrum) |
PF00753(Lactamase_B) | 5 | LEU A 231HIS A 191HIS A 113GLY A 258HIS A 259 | None ZN A 278 ( 3.2A) ZN A 278 ( 3.2A)None ZN A 277 (-3.2A) | 1.46A | 5hm8B-2r2dA:undetectable | 5hm8B-2r2dA:20.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xsr | CATECHOL 1,2DIOXYGENASE (Acinetobacterradioresistens) |
PF00775(Dioxygenase_C)PF04444(Dioxygenase_N) | 5 | ASP A 246LEU A 207GLY A 214HIS A 213PHE A 250 | None | 1.40A | 5hm8B-2xsrA:undetectable | 5hm8B-2xsrA:20.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z1a | 5'-NUCLEOTIDASE (Thermusthermophilus) |
PF00149(Metallophos)PF02872(5_nucleotid_C) | 5 | HIS A 215THR A 172ASP A 83ASP A 119HIS A 240 | ZN A5648 (-3.4A)None ZN A5648 (-2.7A)THM A6510 (-3.7A) ZN A5647 ( 3.5A) | 1.48A | 5hm8B-2z1aA:2.4 | 5hm8B-2z1aA:22.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zwv | PROBABLE RIBOSOMALRNA SMALL SUBUNITMETHYLTRANSFERASE (Thermusthermophilus) |
PF05175(MTS) | 5 | LEU A 293ASP A 290HIS A 9GLY A 241PHE A 299 | NoneNoneNoneSAH A 376 (-3.1A)None | 1.32A | 5hm8B-2zwvA:6.1 | 5hm8B-2zwvA:22.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3azq | AMINOPEPTIDASE (Streptomycesmorookaense) |
PF00326(Peptidase_S9) | 5 | THR A 531ASP A 445LEU A 533GLY A 509PHE A 449 | None | 1.36A | 5hm8B-3azqA:undetectable | 5hm8B-3azqA:20.32 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ce6 | ADENOSYLHOMOCYSTEINASE (Mycobacteriumtuberculosis) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 6 | HIS A 69THR A 74ASP A 156ASP A 252HIS A 363MET A 421 | ADN A 500 (-4.0A)ADN A 500 (-4.5A)ADN A 500 (-2.9A)ADN A 500 (-2.7A)ADN A 500 ( 3.7A)ADN A 500 (-3.7A) | 1.31A | 5hm8B-3ce6A:53.7 | 5hm8B-3ce6A:49.14 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ce6 | ADENOSYLHOMOCYSTEINASE (Mycobacteriumtuberculosis) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | LEU A 68ASP A 156LYS A 248ASP A 252LEU A 407 | NoneADN A 500 (-2.9A)ADN A 500 (-2.8A)ADN A 500 (-2.7A)NAD A 550 (-4.2A) | 1.06A | 5hm8B-3ce6A:53.7 | 5hm8B-3ce6A:49.14 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ce6 | ADENOSYLHOMOCYSTEINASE (Mycobacteriumtuberculosis) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 12 | LEU A 68HIS A 69THR A 71ASP A 156LYS A 248ASP A 252HIS A 363LEU A 410GLY A 415HIS A 416MET A 421PHE A 425 | NoneADN A 500 (-4.0A)ADN A 500 (-2.8A)ADN A 500 (-2.9A)ADN A 500 (-2.8A)ADN A 500 (-2.7A)ADN A 500 ( 3.7A)ADN A 500 ( 4.8A)ADN A 500 ( 3.6A)ADN A 500 ( 3.6A)ADN A 500 (-3.7A)ADN A 500 (-4.8A) | 0.22A | 5hm8B-3ce6A:53.7 | 5hm8B-3ce6A:49.14 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3g1u | ADENOSYLHOMOCYSTEINASE (Leishmaniamajor) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | HIS A 52THR A 57ASP A 130HIS A 300MET A 357 | ADN A 438 (-4.0A)ADN A 438 (-4.6A)ADN A 438 (-4.1A)ADN A 438 ( 4.0A)ADN A 438 (-3.7A) | 1.38A | 5hm8B-3g1uA:50.9 | 5hm8B-3g1uA:50.50 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3g1u | ADENOSYLHOMOCYSTEINASE (Leishmaniamajor) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 10 | LEU A 51HIS A 52THR A 54ASP A 130HIS A 300LEU A 346GLY A 351HIS A 352MET A 357PHE A 361 | NoneADN A 438 (-4.0A)ADN A 438 (-2.8A)ADN A 438 (-4.1A)ADN A 438 ( 4.0A)ADN A 438 ( 4.8A)ADN A 438 ( 3.8A)ADN A 438 ( 3.6A)ADN A 438 (-3.7A)None | 0.52A | 5hm8B-3g1uA:50.9 | 5hm8B-3g1uA:50.50 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3glq | ADENOSYLHOMOCYSTEINASE (Burkholderiapseudomallei) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 6 | HIS A 62THR A 67ASP A 139ASP A 233HIS A 344MET A 399 | RAB A 602 (-3.8A)RAB A 602 (-4.5A)RAB A 602 (-3.0A)RAB A 602 (-2.5A)RAB A 602 ( 3.5A)RAB A 602 (-3.6A) | 1.34A | 5hm8B-3glqA:55.0 | 5hm8B-3glqA:50.78 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3glq | ADENOSYLHOMOCYSTEINASE (Burkholderiapseudomallei) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 6 | LEU A 61ASP A 139LYS A 229ASP A 233LEU A 385HIS A 394 | NoneRAB A 602 (-3.0A)RAB A 602 (-3.0A)RAB A 602 (-2.5A)NAD A 601 ( 4.1A)NAD A 601 ( 3.6A) | 1.24A | 5hm8B-3glqA:55.0 | 5hm8B-3glqA:50.78 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3glq | ADENOSYLHOMOCYSTEINASE (Burkholderiapseudomallei) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 12 | LEU A 61HIS A 62THR A 64ASP A 139LYS A 229ASP A 233HIS A 344LEU A 388GLY A 393HIS A 394MET A 399PHE A 403 | NoneRAB A 602 (-3.8A)RAB A 602 (-2.7A)RAB A 602 (-3.0A)RAB A 602 (-3.0A)RAB A 602 (-2.5A)RAB A 602 ( 3.5A)RAB A 602 ( 4.7A)RAB A 602 ( 3.8A)NAD A 601 ( 3.6A)RAB A 602 (-3.6A)None | 0.23A | 5hm8B-3glqA:55.0 | 5hm8B-3glqA:50.78 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3h9u | ADENOSYLHOMOCYSTEINASE (Trypanosomabrucei) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 6 | HIS A 52ASP A 130LYS A 185ASP A 189LEU A 343HIS A 352 | ADN A 439 ( 4.7A)NoneNAD A 438 ( 3.9A)NAD A 438 ( 4.4A)NAD A 438 (-4.0A)ADN A 439 ( 3.3A) | 1.44A | 5hm8B-3h9uA:52.9 | 5hm8B-3h9uA:51.70 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3h9u | ADENOSYLHOMOCYSTEINASE (Trypanosomabrucei) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | HIS A 52THR A 57ASP A 130ASP A 189HIS A 300 | ADN A 439 ( 4.7A)ADN A 439 (-4.7A)NoneNAD A 438 ( 4.4A)None | 1.32A | 5hm8B-3h9uA:52.9 | 5hm8B-3h9uA:51.70 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3h9u | ADENOSYLHOMOCYSTEINASE (Trypanosomabrucei) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 12 | LEU A 51HIS A 52THR A 54ASP A 130LYS A 185ASP A 189HIS A 300LEU A 346GLY A 351HIS A 352MET A 357PHE A 361 | NoneADN A 439 ( 4.7A)ADN A 439 (-2.7A)NoneNAD A 438 ( 3.9A)NAD A 438 ( 4.4A)NoneADN A 439 ( 4.7A)ADN A 439 (-3.5A)ADN A 439 ( 3.3A)ADN A 439 ( 3.7A)None | 0.23A | 5hm8B-3h9uA:52.9 | 5hm8B-3h9uA:51.70 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3n58 | ADENOSYLHOMOCYSTEINASE (Brucellaabortus) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 6 | HIS A 55THR A 60ASP A 132ASP A 226HIS A 337MET A 392 | ADN A 500 (-4.0A)ADN A 500 (-4.6A)ADN A 500 (-3.3A)ADN A 500 ( 2.6A)ADN A 500 ( 3.6A)ADN A 500 (-3.7A) | 1.31A | 5hm8B-3n58A:55.1 | 5hm8B-3n58A:52.30 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3n58 | ADENOSYLHOMOCYSTEINASE (Brucellaabortus) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 6 | LEU A 54ASP A 132LYS A 222ASP A 226LEU A 378HIS A 387 | NoneADN A 500 (-3.3A)ADN A 500 (-2.7A)ADN A 500 ( 2.6A)NAD A 550 (-4.3A)ADN A 500 (-3.4A) | 1.23A | 5hm8B-3n58A:55.1 | 5hm8B-3n58A:52.30 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3n58 | ADENOSYLHOMOCYSTEINASE (Brucellaabortus) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 12 | LEU A 54HIS A 55THR A 57ASP A 132LYS A 222ASP A 226HIS A 337LEU A 381GLY A 386HIS A 387MET A 392PHE A 396 | NoneADN A 500 (-4.0A)ADN A 500 (-2.8A)ADN A 500 (-3.3A)ADN A 500 (-2.7A)ADN A 500 ( 2.6A)ADN A 500 ( 3.6A)ADN A 500 ( 4.8A)ADN A 500 (-3.7A)ADN A 500 (-3.4A)ADN A 500 (-3.7A)None | 0.25A | 5hm8B-3n58A:55.1 | 5hm8B-3n58A:52.30 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3one | ADENOSYLHOMOCYSTEINASE (Lupinus luteus) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 6 | HIS A 62ASP A 139LYS A 235ASP A 239LEU A 395HIS A 404 | ADE A 506 (-4.6A)NoneNAD A 501 ( 4.2A)NAD A 501 ( 4.5A)NAD A 501 (-4.2A)ADE A 506 (-3.4A) | 1.43A | 5hm8B-3oneA:54.9 | 5hm8B-3oneA:55.91 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3one | ADENOSYLHOMOCYSTEINASE (Lupinus luteus) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | HIS A 62THR A 67ASP A 139ASP A 239HIS A 350 | ADE A 506 (-4.6A)ADE A 506 (-4.5A)NoneNAD A 501 ( 4.5A)None | 1.27A | 5hm8B-3oneA:54.9 | 5hm8B-3oneA:55.91 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3one | ADENOSYLHOMOCYSTEINASE (Lupinus luteus) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 12 | LEU A 61HIS A 62THR A 64ASP A 139LYS A 235ASP A 239HIS A 350LEU A 398GLY A 403HIS A 404MET A 409PHE A 413 | NoneADE A 506 (-4.6A)ADE A 506 (-2.8A)NoneNAD A 501 ( 4.2A)NAD A 501 ( 4.5A)NoneADE A 506 ( 4.7A)ADE A 506 ( 3.6A)ADE A 506 (-3.4A)ADE A 506 (-3.8A)ADE A 506 (-4.9A) | 0.52A | 5hm8B-3oneA:54.9 | 5hm8B-3oneA:55.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pf7 | BENZOYL-COAOXYGENASE COMPONENTB (Azoarcusevansii) |
no annotation | 5 | LEU A 427HIS A 423LYS A 398HIS A 406PHE A 395 | None | 0.92A | 5hm8B-3pf7A:undetectable | 5hm8B-3pf7A:23.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qvn | MANGANESE-CONTAININGSUPEROXIDE DISMUTASE (Candidaalbicans) |
PF00081(Sod_Fe_N)PF02777(Sod_Fe_C) | 5 | HIS A 80ASP A 170HIS A 174GLY A 75PHE A 136 | MN A 207 (-3.4A) MN A 207 (-2.7A) MN A 207 (-3.0A)NoneNone | 1.00A | 5hm8B-3qvnA:undetectable | 5hm8B-3qvnA:18.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sze | SERINE PROTEASE ESPP (Escherichiacoli) |
PF02395(Peptidase_S6) | 5 | LEU A 162THR A 148ASP A 346HIS A 411GLY A 364 | None | 1.39A | 5hm8B-3szeA:undetectable | 5hm8B-3szeA:19.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tad | LIPRIN-BETA-1 (Mus musculus) |
PF00536(SAM_1)PF07647(SAM_2) | 5 | LEU C 726HIS C 727LEU C 692GLY C 691HIS C 793 | None | 1.48A | 5hm8B-3tadC:undetectable | 5hm8B-3tadC:19.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uet | ALPHA-1,3/4-FUCOSIDASE (Bifidobacteriumlongum) |
PF01120(Alpha_L_fucos) | 5 | THR A 82ASP A 87HIS A 99LEU A 91PHE A 291 | None | 1.27A | 5hm8B-3uetA:2.1 | 5hm8B-3uetA:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wfa | ALPHA-GLUCOSIDASE (Bacteroidesthetaiotaomicron) |
PF10566(Glyco_hydro_97)PF14508(GH97_N)PF14509(GH97_C) | 5 | LEU A 597ASP A 558HIS A 507LEU A 389GLY A 329 | None | 1.46A | 5hm8B-3wfaA:undetectable | 5hm8B-3wfaA:22.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c1n | CODEHYDROGENASE/ACETYL-COA SYNTHASE,IRON-SULFUR PROTEIN (Carboxydothermushydrogenoformans) |
PF03599(CdhD) | 5 | LEU B 305ASP B 31GLY B 287HIS B 288PHE B 36 | None | 1.43A | 5hm8B-4c1nB:undetectable | 5hm8B-4c1nB:20.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cw4 | BETA-KETOACYLSYNTHASE (Pseudomonasaeruginosa) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | HIS A 23ASP A 581ASP A 196GLY A 17PHE A 10 | None | 1.23A | 5hm8B-4cw4A:undetectable | 5hm8B-4cw4A:23.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cxo | ENDONUCLEASE 2 (Arabidopsisthaliana) |
PF02265(S1-P1_nuclease) | 5 | HIS A 120ASP A 124ASP A 158HIS A 58LEU A 42 | ZN A 451 ( 3.4A) ZN A 453 (-2.6A) ZN A 452 (-2.0A) ZN A 451 ( 3.2A)None | 1.36A | 5hm8B-4cxoA:undetectable | 5hm8B-4cxoA:18.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4egx | KINESIN-LIKE PROTEINKIF1A (Homo sapiens) |
PF00498(FHA)PF16183(Kinesin_assoc) | 5 | LEU A 494LEU A 531GLY A 519HIS A 540PHE A 543 | None | 1.15A | 5hm8B-4egxA:undetectable | 5hm8B-4egxA:17.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ejq | KINESIN-LIKE PROTEINKIF1A (Homo sapiens) |
PF00498(FHA)PF16183(Kinesin_assoc) | 5 | LEU A 494LEU A 531GLY A 519HIS A 540PHE A 543 | None | 1.08A | 5hm8B-4ejqA:undetectable | 5hm8B-4ejqA:17.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f6e | SUPEROXIDE DISMUTASE[MN], MITOCHONDRIAL (Saccharomycescerevisiae) |
PF00081(Sod_Fe_N)PF02777(Sod_Fe_C) | 5 | HIS A 81ASP A 168HIS A 172GLY A 76PHE A 135 | MN A 301 (-3.4A) MN A 301 (-2.6A) MN A 301 (-3.4A)MLY A 72 ( 3.5A)None | 1.07A | 5hm8B-4f6eA:undetectable | 5hm8B-4f6eA:19.54 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4lvc | S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE(SAHASE) (Bradyrhizobiumelkanii) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 6 | HIS A 58ASP A 135LYS A 227ASP A 231LEU A 383HIS A 392 | ADN A 501 (-4.0A)ADN A 501 (-3.0A)ADN A 501 (-2.7A)ADN A 501 (-3.1A)NAD A 503 ( 3.9A)ADN A 501 (-3.5A) | 1.47A | 5hm8B-4lvcA:54.7 | 5hm8B-4lvcA:51.28 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4lvc | S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE(SAHASE) (Bradyrhizobiumelkanii) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 6 | HIS A 58THR A 63ASP A 135ASP A 231HIS A 342MET A 397 | ADN A 501 (-4.0A)ADN A 501 (-4.5A)ADN A 501 (-3.0A)ADN A 501 (-3.1A)ADN A 501 ( 3.7A)ADN A 501 (-3.7A) | 1.27A | 5hm8B-4lvcA:54.7 | 5hm8B-4lvcA:51.28 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4lvc | S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE(SAHASE) (Bradyrhizobiumelkanii) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 12 | LEU A 57HIS A 58THR A 60ASP A 135LYS A 227ASP A 231HIS A 342LEU A 386GLY A 391HIS A 392MET A 397PHE A 401 | NoneADN A 501 (-4.0A)ADN A 501 (-2.8A)ADN A 501 (-3.0A)ADN A 501 (-2.7A)ADN A 501 (-3.1A)ADN A 501 ( 3.7A)ADN A 501 ( 4.7A)ADN A 501 (-3.6A)ADN A 501 (-3.5A)ADN A 501 (-3.7A)ADN A 501 (-4.8A) | 0.21A | 5hm8B-4lvcA:54.7 | 5hm8B-4lvcA:51.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m0v | EXONUCLEASE SUBUNITSBCD (Escherichiacoli) |
PF00149(Metallophos)PF12320(SbcD_C) | 5 | HIS A 10ASP A 8HIS A 224GLY A 12HIS A 24 | MN A 402 (-3.3A) MN A 402 (-3.2A) MN A 402 (-4.0A)NoneNone | 1.48A | 5hm8B-4m0vA:2.5 | 5hm8B-4m0vA:23.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mo9 | PERIPLASMIC BINDINGPROTEIN (Veillonellaparvula) |
PF01497(Peripla_BP_2) | 5 | ASP A 77LEU A 314GLY A 313MET A 78PHE A 82 | None | 1.31A | 5hm8B-4mo9A:undetectable | 5hm8B-4mo9A:23.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qgs | ALCOHOLDEHYDROGENASE YQHD (Escherichiacoli) |
PF00465(Fe-ADH) | 5 | HIS A 281THR A 274ASP A 194HIS A 198GLY A 270 | ZN A 401 (-3.3A)None ZN A 401 (-2.5A) ZN A 401 (-3.2A)None | 1.30A | 5hm8B-4qgsA:undetectable | 5hm8B-4qgsA:24.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qiw | DNA-DIRECTED RNAPOLYMERASE (Thermococcuskodakarensis) |
PF00562(RNA_pol_Rpb2_6)PF00623(RNA_pol_Rpb1_2)PF04560(RNA_pol_Rpb2_7)PF04561(RNA_pol_Rpb2_2)PF04563(RNA_pol_Rpb2_1)PF04565(RNA_pol_Rpb2_3)PF04566(RNA_pol_Rpb2_4)PF04567(RNA_pol_Rpb2_5)PF04983(RNA_pol_Rpb1_3)PF04997(RNA_pol_Rpb1_1)PF04998(RNA_pol_Rpb1_5)PF05000(RNA_pol_Rpb1_4) | 5 | LEU B1073HIS A 73LYS B1102ASP B1106GLY A 75 | None ZN A1002 (-3.1A)NoneNoneNone | 1.35A | 5hm8B-4qiwB:undetectable | 5hm8B-4qiwB:19.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ud8 | FAD-BINDING AND BBEDOMAIN-CONTAININGPROTEIN (Arabidopsisthaliana) |
PF01565(FAD_binding_4)PF08031(BBE) | 5 | LEU A 178LYS A 436HIS A 187GLY A 201PHE A 290 | FAD A 601 (-3.9A)NoneFAD A 601 (-4.0A)NoneNone | 1.43A | 5hm8B-4ud8A:undetectable | 5hm8B-4ud8A:22.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gr1 | 1,4-ALPHA-GLUCANBRANCHING ENZYMEGLGB (Cyanothece sp.ATCC 51142) |
PF00128(Alpha-amylase)PF02806(Alpha-amylase_C)PF02922(CBM_48) | 5 | ASP A 113HIS A 122LEU A 129GLY A 130HIS A 132 | None | 1.40A | 5hm8B-5gr1A:undetectable | 5hm8B-5gr1A:21.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jiu | RAN-BINDING PROTEIN9 (Homo sapiens) |
PF00622(SPRY) | 5 | HIS A 255ASP A 258LEU A 244GLY A 317PHE A 275 | None | 1.38A | 5hm8B-5jiuA:undetectable | 5hm8B-5jiuA:19.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kqc | PEPTIDASE M23 (Staphylococcusaureus) |
PF01551(Peptidase_M23) | 5 | HIS A 159ASP A 80HIS A 76LEU A 124GLY A 106 | ZN A 201 (-3.2A) ZN A 201 (-1.5A) ZN A 201 (-3.7A)NoneNone | 1.49A | 5hm8B-5kqcA:undetectable | 5hm8B-5kqcA:14.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uq6 | TARTRATE-RESISTANTACID PHOSPHATASETYPE 5 (Sus scrofa) |
PF00149(Metallophos) | 5 | LEU A 95HIS A 92ASP A 146GLY A 51HIS A 186 | NonePO4 A 404 (-3.7A)PO4 A 404 ( 4.6A)None FE A 403 ( 3.4A) | 1.45A | 5hm8B-5uq6A:2.0 | 5hm8B-5uq6A:21.29 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5utu | ADENOSYLHOMOCYSTEINASE (Cryptosporidiumparvum) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 6 | HIS A 53ASP A 137LYS A 241ASP A 245LEU A 401HIS A 410 | SAH A 502 (-4.0A)SAH A 502 (-3.4A)SAH A 502 (-2.9A)SAH A 502 (-2.8A)NAD A 501 (-4.1A)SAH A 502 ( 3.5A) | 1.48A | 5hm8B-5utuA:62.7 | 5hm8B-5utuA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5utu | ADENOSYLHOMOCYSTEINASE (Cryptosporidiumparvum) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 11 | LEU A 52HIS A 53THR A 55ASP A 137LYS A 241ASP A 245LEU A 404GLY A 409HIS A 410MET A 415PHE A 419 | NoneSAH A 502 (-4.0A)SAH A 502 (-2.7A)SAH A 502 (-3.4A)SAH A 502 (-2.9A)SAH A 502 (-2.8A)SAH A 502 ( 4.7A)SAH A 502 ( 3.7A)SAH A 502 ( 3.5A)SAH A 502 (-3.6A)SAH A 502 (-4.8A) | 0.13A | 5hm8B-5utuA:62.7 | 5hm8B-5utuA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5v96 | S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE (Naegleriafowleri) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 6 | HIS A 59ASP A 136LYS A 227ASP A 231LEU A 386HIS A 395 | ADN A 502 ( 3.9A)ADN A 502 (-2.9A)ADN A 502 (-2.9A)ADN A 502 (-2.8A)NAD A 501 (-3.9A)ADN A 502 ( 3.4A) | 1.49A | 5hm8B-5v96A:55.5 | 5hm8B-5v96A:54.62 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5v96 | S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE (Naegleriafowleri) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 11 | LEU A 58HIS A 59THR A 61ASP A 136LYS A 227ASP A 231LEU A 389GLY A 394HIS A 395MET A 400PHE A 404 | NoneADN A 502 ( 3.9A)ADN A 502 (-2.9A)ADN A 502 (-2.9A)ADN A 502 (-2.9A)ADN A 502 (-2.8A)ADN A 502 ( 4.7A)ADN A 502 (-3.7A)ADN A 502 ( 3.4A)ADN A 502 (-3.8A)ADN A 502 (-4.9A) | 0.19A | 5hm8B-5v96A:55.5 | 5hm8B-5v96A:54.62 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5w4b | ADENOSYLHOMOCYSTEINASE (Homo sapiens) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 7 | LEU A 54ASP A 131LYS A 186ASP A 190HIS A 353MET A 358PHE A 362 | NoneNoneNoneNAD A 501 (-4.1A)NAD A 501 (-4.5A)9W4 A 502 (-3.6A)None | 0.87A | 5hm8B-5w4bA:44.5 | 5hm8B-5w4bA:48.30 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5w4b | ADENOSYLHOMOCYSTEINASE (Homo sapiens) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 8 | LEU A 54HIS A 55THR A 57ASP A 131LYS A 186ASP A 190MET A 358PHE A 362 | None9W4 A 502 (-3.7A)9W4 A 502 (-2.9A)NoneNoneNAD A 501 (-4.1A)9W4 A 502 (-3.6A)None | 0.70A | 5hm8B-5w4bA:44.5 | 5hm8B-5w4bA:48.30 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5w4b | ADENOSYLHOMOCYSTEINASE (Homo sapiens) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 6 | LYS A 186ASP A 190GLY A 352HIS A 353MET A 358PHE A 362 | NoneNAD A 501 (-4.1A)9W4 A 502 ( 3.9A)NAD A 501 (-4.5A)9W4 A 502 (-3.6A)None | 0.91A | 5hm8B-5w4bA:44.5 | 5hm8B-5w4bA:48.30 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5w4b | ADENOSYLHOMOCYSTEINASE (Homo sapiens) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 6 | LYS A 186ASP A 190LEU A 347GLY A 352HIS A 353MET A 358 | NoneNAD A 501 (-4.1A)9W4 A 502 (-4.1A)9W4 A 502 ( 3.9A)NAD A 501 (-4.5A)9W4 A 502 (-3.6A) | 0.88A | 5hm8B-5w4bA:44.5 | 5hm8B-5w4bA:48.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xgs | RCC1-LIKE GEXCHANGINGFACTOR-LIKE PROTEIN (Homo sapiens) |
PF00415(RCC1)PF13540(RCC1_2) | 5 | LEU A 187HIS A 185GLY A 255HIS A 241PHE A 244 | None | 1.40A | 5hm8B-5xgsA:undetectable | 5hm8B-5xgsA:21.26 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6aph | ADENOSYLHOMOCYSTEINASE (Elizabethkingiaanophelis) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 6 | HIS A 58THR A 63ASP A 136ASP A 195HIS A 306MET A 363 | ADN A 501 (-3.9A)ADN A 501 (-4.5A)ADN A 501 (-3.0A)ADN A 501 (-2.7A)ADN A 501 ( 3.7A)ADN A 501 (-3.7A) | 1.29A | 5hm8B-6aphA:28.9 | 5hm8B-6aphA:45.87 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6aph | ADENOSYLHOMOCYSTEINASE (Elizabethkingiaanophelis) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 6 | LEU A 57ASP A 136LYS A 191ASP A 195LEU A 349HIS A 358 | NoneADN A 501 (-3.0A)ADN A 501 (-2.8A)ADN A 501 (-2.7A)NAD A 500 ( 4.3A)ADN A 501 ( 3.5A) | 1.27A | 5hm8B-6aphA:28.9 | 5hm8B-6aphA:45.87 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6aph | ADENOSYLHOMOCYSTEINASE (Elizabethkingiaanophelis) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 12 | LEU A 57HIS A 58THR A 60ASP A 136LYS A 191ASP A 195HIS A 306LEU A 352GLY A 357HIS A 358MET A 363PHE A 367 | NoneADN A 501 (-3.9A)ADN A 501 (-2.8A)ADN A 501 (-3.0A)ADN A 501 (-2.8A)ADN A 501 (-2.7A)ADN A 501 ( 3.7A)ADN A 501 ( 4.8A)ADN A 501 (-3.6A)ADN A 501 ( 3.5A)ADN A 501 (-3.7A)None | 0.23A | 5hm8B-6aphA:28.9 | 5hm8B-6aphA:45.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cey | BIFUNCTIONAL AAC/APH (Staphylococcusaureus) |
no annotation | 5 | LEU A 247ASP A 405GLY A 311HIS A 310PHE A 305 | None | 1.46A | 5hm8B-6ceyA:undetectable | 5hm8B-6ceyA:11.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f3m | - (-) |
no annotation | 6 | HIS B 61ASP B 139LYS B 194ASP B 198LEU B 373HIS B 382 | ADN B 502 ( 4.0A) ZN B 505 ( 2.5A)ADN B 502 (-2.8A)ADN B 502 (-2.7A)NAD B 501 ( 3.9A)ADN B 502 (-3.4A) | 1.44A | 5hm8B-6f3mB:49.3 | 5hm8B-6f3mB:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f3m | - (-) |
no annotation | 11 | HIS B 61THR B 63ASP B 139LYS B 194ASP B 198HIS B 323LEU B 376GLY B 381HIS B 382MET B 387PHE B 391 | ADN B 502 ( 4.0A)ADN B 502 (-2.8A) ZN B 505 ( 2.5A)ADN B 502 (-2.8A)ADN B 502 (-2.7A) ZN B 505 (-3.2A)ADN B 502 ( 4.8A)ADN B 502 ( 3.7A)ADN B 502 (-3.4A)ADN B 502 (-3.7A)ADN B 502 (-4.9A) | 0.24A | 5hm8B-6f3mB:49.3 | 5hm8B-6f3mB:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f3m | - (-) |
no annotation | 6 | HIS B 61THR B 66ASP B 139ASP B 198HIS B 323MET B 387 | ADN B 502 ( 4.0A)ADN B 502 (-4.6A) ZN B 505 ( 2.5A)ADN B 502 (-2.7A) ZN B 505 (-3.2A)ADN B 502 (-3.7A) | 1.30A | 5hm8B-6f3mB:49.3 | 5hm8B-6f3mB:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6gbn | - (-) |
no annotation | 6 | HIS A 56ASP A 134LYS A 189ASP A 193LEU A 347HIS A 356 | ADN A 501 (-3.9A)ADN A 501 (-2.9A)ADN A 501 (-2.9A)ADN A 501 (-2.7A)NAD A 502 (-3.9A)ADN A 501 (-3.4A) | 1.46A | 5hm8B-6gbnA:27.3 | 5hm8B-6gbnA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6gbn | - (-) |
no annotation | 6 | HIS A 56THR A 61ASP A 134ASP A 193HIS A 304MET A 361 | ADN A 501 (-3.9A)ADN A 501 (-4.6A)ADN A 501 (-2.9A)ADN A 501 (-2.7A)ADN A 501 ( 3.6A)ADN A 501 (-3.6A) | 1.28A | 5hm8B-6gbnA:27.3 | 5hm8B-6gbnA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6gbn | - (-) |
no annotation | 12 | LEU A 55HIS A 56THR A 58ASP A 134LYS A 189ASP A 193HIS A 304LEU A 350GLY A 355HIS A 356MET A 361PHE A 365 | NoneADN A 501 (-3.9A)ADN A 501 (-2.8A)ADN A 501 (-2.9A)ADN A 501 (-2.9A)ADN A 501 (-2.7A)ADN A 501 ( 3.6A)ADN A 501 ( 4.7A)ADN A 501 (-3.8A)ADN A 501 (-3.4A)ADN A 501 (-3.6A)None | 0.21A | 5hm8B-6gbnA:27.3 | 5hm8B-6gbnA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dlc | DELTA-ENDOTOXINCRYIIIA (Bacillusthuringiensis) |
PF00555(Endotoxin_M)PF03944(Endotoxin_C)PF03945(Endotoxin_N) | 4 | GLU A 639THR A 510GLU A 298LEU A 282 | None | 1.15A | 5hm8B-1dlcA:undetectable | 5hm8B-1dlcA:21.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hfy | ALPHA-LACTALBUMIN (Capra hircus) |
PF00062(Lys) | 4 | THR A 33GLU A 49THR A 48LEU A 81 | None | 1.23A | 5hm8B-1hfyA:undetectable | 5hm8B-1hfyA:12.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hml | ALPHA-LACTALBUMIN (Homo sapiens) |
PF00062(Lys) | 4 | THR A 33GLU A 49THR A 48LEU A 81 | None ZN A 125 ( 2.1A)NoneNone | 1.26A | 5hm8B-1hmlA:undetectable | 5hm8B-1hmlA:15.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ji6 | PESTICIDIAL CRYSTALPROTEIN CRY3BB (Bacillusthuringiensis) |
PF00555(Endotoxin_M)PF03944(Endotoxin_C)PF03945(Endotoxin_N) | 4 | GLU A 646THR A 513GLU A 299LEU A 283 | None | 1.12A | 5hm8B-1ji6A:undetectable | 5hm8B-1ji6A:21.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nf5 | ALPHA-LACTALBUMIN (Mus musculus) |
PF00062(Lys) | 4 | THR A 33GLU A 49THR A 48LEU A 81 | None | 1.22A | 5hm8B-1nf5A:undetectable | 5hm8B-1nf5A:12.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ort | ORNITHINETRANSCARBAMOYLASE (Pseudomonasaeruginosa) |
PF00185(OTCace)PF02729(OTCace_N) | 4 | GLU A 249GLU A 216THR A 215LEU A 161 | None | 1.26A | 5hm8B-1ortA:4.7 | 5hm8B-1ortA:22.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1oru | YUAD PROTEIN (Bacillussubtilis) |
no annotation | 4 | GLU A 10GLU A 89THR A 22LEU A 28 | None | 1.17A | 5hm8B-1oruA:undetectable | 5hm8B-1oruA:17.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qhg | ATP-DEPENDENTHELICASE PCRA (Geobacillusstearothermophilus) |
PF00580(UvrD-helicase)PF13361(UvrD_C) | 4 | GLU A 523THR A 519GLU A 485LEU A 474 | None | 1.24A | 5hm8B-1qhgA:undetectable | 5hm8B-1qhgA:21.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v72 | ALDOLASE (Pseudomonasputida) |
PF01212(Beta_elim_lyase) | 4 | GLU A 132THR A 130THR A 80LEU A 111 | None | 1.01A | 5hm8B-1v72A:undetectable | 5hm8B-1v72A:20.63 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1v8b | ADENOSYLHOMOCYSTEINASE (Plasmodiumfalciparum) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 4 | GLU A 58GLU A 200THR A 201LEU A 389 | ADN A 502 (-3.6A)ADN A 502 (-4.0A)NAD A 501 ( 2.8A)NAD A 501 ( 3.8A) | 0.18A | 5hm8B-1v8bA:56.0 | 5hm8B-1v8bA:52.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wuf | HYPOTHETICAL PROTEINLIN2664 (Listeriainnocua) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | GLU A1240THR A1057GLU A1098LEU A1262 | MG A5001 (-3.1A)NoneNoneNone | 1.24A | 5hm8B-1wufA:undetectable | 5hm8B-1wufA:23.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1x5r | GLUTAMATE RECEPTORINTERACTING PROTEIN2 (Homo sapiens) |
PF00595(PDZ) | 4 | GLU A 79THR A 78GLU A 102THR A 17 | None | 1.17A | 5hm8B-1x5rA:undetectable | 5hm8B-1x5rA:13.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ytu | HYPOTHETICAL PROTEINAF1318 (Archaeoglobusfulgidus) |
PF02171(Piwi) | 4 | GLU A 264THR A 265THR A 250LEU A 292 | None | 1.11A | 5hm8B-1ytuA:2.2 | 5hm8B-1ytuA:22.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yvd | RAS-RELATED PROTEINRAB-22A (Mus musculus) |
PF00071(Ras) | 4 | GLU A 127THR A 88GLU A 146LEU A 96 | None | 1.17A | 5hm8B-1yvdA:4.8 | 5hm8B-1yvdA:16.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z0a | RAS-RELATED PROTEINRAB-2A (Homo sapiens) |
PF00071(Ras) | 4 | GLU A 128THR A 89GLU A 147LEU A 97 | None | 1.24A | 5hm8B-1z0aA:2.6 | 5hm8B-1z0aA:17.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z1w | TRICORN PROTEASEINTERACTING FACTORF3 (Thermoplasmaacidophilum) |
PF01433(Peptidase_M1)PF11838(ERAP1_C) | 4 | GLU A 694THR A 695THR A 633LEU A 639 | None | 1.26A | 5hm8B-1z1wA:undetectable | 5hm8B-1z1wA:22.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bvm | TOXIN B (Clostridioidesdifficile) |
PF12918(TcdB_N)PF12919(TcdA_TcdB) | 4 | GLU A 82THR A 81THR A 56LEU A 9 | None | 1.23A | 5hm8B-2bvmA:undetectable | 5hm8B-2bvmA:23.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c9k | PESTICIDAL CRYSTALPROTEIN CRY4AA (Bacillusthuringiensis) |
PF00555(Endotoxin_M)PF03944(Endotoxin_C)PF03945(Endotoxin_N) | 4 | GLU A 673THR A 539GLU A 325LEU A 309 | None | 1.15A | 5hm8B-2c9kA:undetectable | 5hm8B-2c9kA:22.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fe0 | SMALL MYRISTOYLATEDPROTEIN 1 (Leishmaniamajor) |
PF09149(DUF1935) | 4 | GLU A 121GLU A 97THR A 98LEU A 37 | None | 1.16A | 5hm8B-2fe0A:undetectable | 5hm8B-2fe0A:14.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pq7 | PREDICTED HDSUPERFAMILYHYDROLASE (unculturedThermotogalesbacterium) |
PF01966(HD) | 4 | GLU A 187GLU A 192THR A 193LEU A 133 | None | 1.24A | 5hm8B-2pq7A:undetectable | 5hm8B-2pq7A:18.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qqm | NEUROPILIN-1 (Homo sapiens) |
PF00431(CUB)PF00754(F5_F8_type_C) | 4 | GLU A 586GLU A 492THR A 559LEU A 435 | None | 1.23A | 5hm8B-2qqmA:undetectable | 5hm8B-2qqmA:21.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qua | EXTRACELLULAR LIPASE (Serratiamarcescens) |
no annotation | 4 | THR A 524GLU A 427THR A 426LEU A 435 | None | 0.93A | 5hm8B-2quaA:3.4 | 5hm8B-2quaA:20.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wmo | DEDICATOR OFCYTOKINESIS PROTEIN9 (Homo sapiens) |
PF06920(DHR-2) | 4 | GLU A 143THR A 142GLU A 105LEU A 134 | None | 1.09A | 5hm8B-2wmoA:undetectable | 5hm8B-2wmoA:23.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ygk | NURA (Sulfolobussolfataricus) |
PF09376(NurA) | 4 | GLU A 225THR A 224GLU A 221LEU A 263 | None | 1.14A | 5hm8B-2ygkA:undetectable | 5hm8B-2ygkA:22.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yu6 | YTHDOMAIN-CONTAININGPROTEIN 2 (Homo sapiens) |
PF04146(YTH) | 4 | GLU A 71GLU A 37THR A 32LEU A 52 | None | 1.23A | 5hm8B-2yu6A:undetectable | 5hm8B-2yu6A:13.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yv2 | SUCCINYL-COASYNTHETASE ALPHACHAIN (Aeropyrumpernix) |
PF00549(Ligase_CoA)PF02629(CoA_binding) | 4 | GLU A 13THR A 14THR A 124LEU A 200 | None | 1.15A | 5hm8B-2yv2A:2.3 | 5hm8B-2yv2A:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a0f | XYLOGLUCANASE (Geotrichum sp.M128) |
no annotation | 4 | GLU A 435THR A 437THR A 406LEU A 374 | None | 1.00A | 5hm8B-3a0fA:undetectable | 5hm8B-3a0fA:20.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a24 | ALPHA-GALACTOSIDASE (Bacteroidesthetaiotaomicron) |
PF10566(Glyco_hydro_97)PF14508(GH97_N)PF14509(GH97_C) | 4 | GLU A 213THR A 425GLU A 209THR A 208 | None | 1.22A | 5hm8B-3a24A:undetectable | 5hm8B-3a24A:22.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3axs | PROBABLEN(2),N(2)-DIMETHYLGUANOSINE TRNAMETHYLTRANSFERASETRM1 (Aquifexaeolicus) |
PF02005(TRM) | 4 | GLU A 73THR A 74GLU A 296LEU A 38 | None | 1.14A | 5hm8B-3axsA:2.8 | 5hm8B-3axsA:20.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bpv | TRANSCRIPTIONALREGULATOR (Methanothermobacterthermautotrophicus) |
PF01047(MarR) | 4 | GLU A 45GLU A 92THR A 94LEU A 39 | None | 1.23A | 5hm8B-3bpvA:undetectable | 5hm8B-3bpvA:13.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bz6 | UPF0502 PROTEINPSPTO_2686 (Pseudomonassyringae groupgenomosp. 3) |
PF04337(DUF480) | 4 | GLU A 77GLU A 23THR A 22LEU A 48 | None | 1.19A | 5hm8B-3bz6A:undetectable | 5hm8B-3bz6A:18.47 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ce6 | ADENOSYLHOMOCYSTEINASE (Mycobacteriumtuberculosis) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 4 | THR A 74GLU A 218THR A 219LEU A 407 | ADN A 500 (-4.5A)ADN A 500 (-2.6A)NAD A 550 ( 2.8A)NAD A 550 (-4.2A) | 1.02A | 5hm8B-3ce6A:53.7 | 5hm8B-3ce6A:49.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d6c | THERMONUCLEASE (Staphylococcusaureus) |
PF00565(SNase) | 4 | GLU A 52THR A 44GLU A 57LEU A 103 | None | 1.11A | 5hm8B-3d6cA:undetectable | 5hm8B-3d6cA:16.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dpu | RAB FAMILY PROTEIN (Chlorobaculumtepidum) |
PF08477(Roc)PF16095(COR) | 4 | GLU A 668THR A 664GLU A 655LEU A 639 | None | 1.25A | 5hm8B-3dpuA:undetectable | 5hm8B-3dpuA:23.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eo8 | BLUB-LIKEFLAVOPROTEIN (Clostridioidesdifficile) |
PF00881(Nitroreductase) | 4 | GLU A 57GLU A 179THR A 180LEU A 104 | None | 1.20A | 5hm8B-3eo8A:undetectable | 5hm8B-3eo8A:18.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f2b | DNA-DIRECTED DNAPOLYMERASE III ALPHACHAIN (Geobacilluskaustophilus) |
PF02811(PHP)PF07733(DNA_pol3_alpha)PF14579(HHH_6) | 4 | GLU A1197GLU A1169THR A1170LEU A1184 | None | 1.03A | 5hm8B-3f2bA:undetectable | 5hm8B-3f2bA:20.75 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3g1u | ADENOSYLHOMOCYSTEINASE (Leishmaniamajor) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 4 | THR A 57GLU A 155THR A 156LEU A 343 | ADN A 438 (-4.6A)ADN A 438 (-3.8A)NAD A 439 ( 3.0A)NAD A 439 ( 4.0A) | 0.58A | 5hm8B-3g1uA:50.9 | 5hm8B-3g1uA:50.50 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3glq | ADENOSYLHOMOCYSTEINASE (Burkholderiapseudomallei) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 4 | THR A 67GLU A 199THR A 200LEU A 385 | RAB A 602 (-4.5A)RAB A 602 (-4.6A)NAD A 601 ( 2.9A)NAD A 601 ( 4.1A) | 0.68A | 5hm8B-3glqA:55.0 | 5hm8B-3glqA:50.78 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3h9u | ADENOSYLHOMOCYSTEINASE (Trypanosomabrucei) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 4 | THR A 57GLU A 155THR A 156LEU A 343 | ADN A 439 (-4.7A)NoneNAD A 438 (-3.8A)NAD A 438 (-4.0A) | 0.48A | 5hm8B-3h9uA:52.9 | 5hm8B-3h9uA:51.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hq2 | BACILLUS SUBTILISM32 CARBOXYPEPTIDASE (Bacillussubtilis) |
PF02074(Peptidase_M32) | 4 | GLU A 273THR A 238GLU A 266THR A 263 | NoneNonePO4 A 503 (-3.0A)None | 1.15A | 5hm8B-3hq2A:undetectable | 5hm8B-3hq2A:23.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mln | TRANSCRIPTION FACTORCOE1 (Mus musculus) |
PF16422(COE1_DBD) | 4 | GLU A 123THR A 122GLU A 85LEU A 188 | None | 1.18A | 5hm8B-3mlnA:undetectable | 5hm8B-3mlnA:17.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n0u | PROBABLEN-GLYCOSYLASE/DNALYASE (Thermotogamaritima) |
no annotation | 4 | THR A 48GLU A 41THR A 138LEU A 119 | None | 1.15A | 5hm8B-3n0uA:undetectable | 5hm8B-3n0uA:17.87 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3n58 | ADENOSYLHOMOCYSTEINASE (Brucellaabortus) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 4 | THR A 60GLU A 192THR A 193LEU A 378 | ADN A 500 (-4.6A)ADN A 500 (-3.6A)NAD A 550 ( 3.0A)NAD A 550 (-4.3A) | 0.49A | 5hm8B-3n58A:55.1 | 5hm8B-3n58A:52.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3now | UNC-45 PROTEIN,SD10334P (Drosophilamelanogaster) |
PF11701(UNC45-central) | 4 | GLU A 198THR A 195THR A 248LEU A 169 | None | 1.00A | 5hm8B-3nowA:undetectable | 5hm8B-3nowA:22.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nrv | PUTATIVETRANSCRIPTIONALREGULATOR (MARR/EMRRFAMILY) (Acinetobactersp. ADP1) |
PF12802(MarR_2) | 4 | THR A 30GLU A 39THR A 71LEU A 61 | SO4 A 147 (-4.0A)NoneNoneNone | 1.21A | 5hm8B-3nrvA:undetectable | 5hm8B-3nrvA:14.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nsj | PERFORIN-1 (Mus musculus) |
PF00168(C2)PF01823(MACPF) | 4 | GLU A 174THR A 172GLU A 119LEU A 52 | None | 1.25A | 5hm8B-3nsjA:undetectable | 5hm8B-3nsjA:20.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3odw | RHO GUANINENUCLEOTIDE EXCHANGEFACTOR 1 (Homo sapiens) |
PF00621(RhoGEF) | 4 | GLU A 581THR A 579GLU A 589LEU A 497 | None | 1.14A | 5hm8B-3odwA:undetectable | 5hm8B-3odwA:20.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3odx | RHO GUANINENUCLEOTIDE EXCHANGEFACTOR 1 (Homo sapiens) |
PF00621(RhoGEF) | 4 | GLU A 581THR A 579GLU A 589LEU A 497 | None | 1.13A | 5hm8B-3odxA:undetectable | 5hm8B-3odxA:21.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ogk | CORONATINE-INSENSITIVE PROTEIN 1 (Arabidopsisthaliana) |
no annotation | 4 | GLU B 234GLU B 213THR B 214LEU B 184 | None | 1.10A | 5hm8B-3ogkB:undetectable | 5hm8B-3ogkB:21.60 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3one | ADENOSYLHOMOCYSTEINASE (Lupinus luteus) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 4 | THR A 67GLU A 205THR A 206LEU A 395 | ADE A 506 (-4.5A)NoneNAD A 501 (-2.8A)NAD A 501 (-4.2A) | 0.29A | 5hm8B-3oneA:54.9 | 5hm8B-3oneA:55.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oth | CALG1 (Micromonosporaechinospora) |
PF00201(UDPGT)PF03033(Glyco_transf_28) | 4 | GLU A 117THR A 14THR A 32LEU A 102 | None | 1.09A | 5hm8B-3othA:7.4 | 5hm8B-3othA:22.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3swj | PUTATIVEUNCHARACTERIZEDPROTEIN (Campylobacterjejuni) |
PF01243(Putative_PNPOx)PF10615(DUF2470) | 4 | THR A 193GLU A 188THR A 122LEU A 210 | None | 1.25A | 5hm8B-3swjA:undetectable | 5hm8B-3swjA:19.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3thw | DNA MISMATCH REPAIRPROTEIN MSH3 (Homo sapiens) |
PF00488(MutS_V)PF01624(MutS_I)PF05188(MutS_II)PF05192(MutS_III) | 4 | GLU B 302THR B 301GLU B 242LEU B 223 | None | 0.90A | 5hm8B-3thwB:undetectable | 5hm8B-3thwB:19.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tr5 | PEPTIDE CHAINRELEASE FACTOR 3 (Coxiellaburnetii) |
PF00009(GTP_EFTU)PF16658(RF3_C) | 4 | GLU A 521THR A 522GLU A 94LEU A 123 | None | 0.86A | 5hm8B-3tr5A:2.3 | 5hm8B-3tr5A:23.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u7z | PUTATIVE METALBINDING PROTEINRUMGNA_00854 ([Ruminococcus]gnavus) |
PF14478(DUF4430) | 4 | GLU A 50THR A 49GLU A 89LEU A 71 | None | 1.23A | 5hm8B-3u7zA:undetectable | 5hm8B-3u7zA:12.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vz0 | PUTATIVENAD-DEPENDENTALDEHYDEDEHYDROGENASE (Gluconobacteroxydans) |
PF00171(Aldedh) | 4 | GLU A 74GLU A 85THR A 89LEU A 171 | None | 1.18A | 5hm8B-3vz0A:2.8 | 5hm8B-3vz0A:23.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4agu | CYCLIN-DEPENDENTKINASE-LIKE 1 (Homo sapiens) |
PF00069(Pkinase) | 4 | GLU A 247THR A 217GLU A 250LEU A 196 | None | 1.26A | 5hm8B-4aguA:undetectable | 5hm8B-4aguA:21.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ayg | GLUCANSUCRASE (Lactobacillusreuteri) |
PF01473(CW_binding_1)PF02324(Glyco_hydro_70) | 4 | GLU A 841GLU A 812THR A 822LEU A1620 | None | 0.97A | 5hm8B-4aygA:undetectable | 5hm8B-4aygA:19.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c1n | CARBON MONOXIDEDEHYDROGENASECORRINOID/IRON-SULFUR PROTEIN, GAMMASUBUNIT (Carboxydothermushydrogenoformans) |
PF03599(CdhD)PF04060(FeS) | 4 | GLU A 165GLU A 172THR A 173LEU A 160 | None | 1.11A | 5hm8B-4c1nA:undetectable | 5hm8B-4c1nA:24.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c23 | L-FUCULOSE KINASEFUCK (Streptococcuspneumoniae) |
PF00370(FGGY_N)PF02782(FGGY_C) | 4 | GLU A 245THR A 244GLU A 261LEU A 385 | None | 1.19A | 5hm8B-4c23A:undetectable | 5hm8B-4c23A:23.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4evw | NUCLEOSIDE-DIPHOSPHATE-SUGARPYROPHOSPHORYLASE (Vibrio cholerae) |
no annotation | 4 | GLU A 202GLU A 89THR A 92LEU A 208 | None | 1.14A | 5hm8B-4evwA:undetectable | 5hm8B-4evwA:18.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fml | VSDC (Aeromonashydrophila) |
PF03496(ADPrib_exo_Tox) | 4 | GLU A 173THR A 222GLU A 131LEU A 204 | None | 1.17A | 5hm8B-4fmlA:undetectable | 5hm8B-4fmlA:17.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fr4 | SERINE/THREONINE-PROTEIN KINASE 32A (Homo sapiens) |
PF00069(Pkinase) | 4 | GLU A 215THR A 212THR A 122LEU A 154 | None | 1.24A | 5hm8B-4fr4A:undetectable | 5hm8B-4fr4A:20.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4id9 | SHORT-CHAINDEHYDROGENASE/REDUCTASE (Agrobacteriumfabrum) |
PF01370(Epimerase) | 4 | THR A 289GLU A 122THR A 249LEU A 126 | None | 0.87A | 5hm8B-4id9A:7.2 | 5hm8B-4id9A:19.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iqz | DNA-DIRECTED RNAPOLYMERASE SUBUNITBETA' (Escherichiacoli) |
no annotation | 4 | GLU A 82GLU A 70THR A 69LEU A 92 | NoneIOD A 309 (-3.7A)NoneNone | 1.00A | 5hm8B-4iqzA:undetectable | 5hm8B-4iqzA:19.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j57 | THIOREDOXINREDUCTASE 2 (Plasmodiumfalciparum) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 4 | THR A 486GLU A 402THR A 399LEU A 257 | None | 1.26A | 5hm8B-4j57A:3.7 | 5hm8B-4j57A:21.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k92 | CLIP-ASSOCIATINGPROTEIN 1 (Homo sapiens) |
PF12348(CLASP_N) | 4 | GLU A 339GLU A 387THR A 391LEU A 331 | None | 1.23A | 5hm8B-4k92A:undetectable | 5hm8B-4k92A:19.21 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4lvc | S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE(SAHASE) (Bradyrhizobiumelkanii) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 4 | THR A 63GLU A 197THR A 198LEU A 383 | ADN A 501 (-4.5A)ADN A 501 (-3.6A)NAD A 503 ( 2.9A)NAD A 503 ( 3.9A) | 0.20A | 5hm8B-4lvcA:54.7 | 5hm8B-4lvcA:51.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nq8 | PUTATIVE PERIPLASMICSUBSTRATE-BINDINGTRANSPORT PROTEIN (Bordetellabronchiseptica) |
PF03480(DctP) | 4 | GLU A 172THR A 171THR A 101LEU A 237 | NonePAF A 401 (-4.5A)NoneNone | 1.14A | 5hm8B-4nq8A:undetectable | 5hm8B-4nq8A:22.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4up5 | PYGOPUS HOMOLOG 2,B-CELL CLL/LYMPHOMA9-LIKE PROTEIN (Homo sapiens) |
PF00628(PHD) | 4 | GLU A 372THR A 371THR A 362LEU A1251 | None | 1.02A | 5hm8B-4up5A:undetectable | 5hm8B-4up5A:12.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uqz | HSIE1 (Pseudomonasaeruginosa) |
PF07024(ImpE) | 4 | GLU A 238THR A 239GLU A 254LEU A 266 | None | 1.07A | 5hm8B-4uqzA:undetectable | 5hm8B-4uqzA:18.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4y4r | BIFUNCTIONALLYSINE-SPECIFICDEMETHYLASE ANDHISTIDYL-HYDROXYLASENO66 (Homo sapiens) |
PF08007(Cupin_4) | 4 | GLU A 592GLU A 535THR A 534LEU A 620 | None | 1.25A | 5hm8B-4y4rA:undetectable | 5hm8B-4y4rA:22.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zi6 | CYTOSOLAMINOPEPTIDASE (Helicobacterpylori) |
PF00883(Peptidase_M17)PF02789(Peptidase_M17_N) | 4 | GLU A 312THR A 311GLU A 342THR A 339 | NoneNone ZN A 501 (-2.5A)None | 1.19A | 5hm8B-4zi6A:undetectable | 5hm8B-4zi6A:22.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zsb | HTH-TYPETRANSCRIPTIONALREPRESSOR DASR (Streptomycescoelicolor) |
PF07702(UTRA) | 4 | THR A 99GLU A 154THR A 156LEU A 188 | None | 1.26A | 5hm8B-4zsbA:undetectable | 5hm8B-4zsbA:16.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5aga | DNA POLYMERASE THETA (Homo sapiens) |
PF00270(DEAD)PF00271(Helicase_C) | 4 | GLU A 332THR A 333THR A 488LEU A 293 | None | 1.20A | 5hm8B-5agaA:undetectable | 5hm8B-5agaA:23.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cwp | DESIGNED HELICALREPEAT PROTEIN (syntheticconstruct) |
no annotation | 4 | GLU A 83THR A 85GLU A 136LEU A 97 | None | 1.13A | 5hm8B-5cwpA:undetectable | 5hm8B-5cwpA:19.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ehk | LANTIBIOTICDEHYDRATASE (Microbisporacorallina) |
PF04738(Lant_dehydr_N)PF14028(Lant_dehydr_C) | 4 | GLU A 482THR A 484THR A 686LEU A 394 | None | 1.23A | 5hm8B-5ehkA:undetectable | 5hm8B-5ehkA:17.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5epg | ALDEHYDE OXIDASE (Homo sapiens) |
PF00111(Fer2)PF00941(FAD_binding_5)PF01315(Ald_Xan_dh_C)PF01799(Fer2_2)PF02738(Ald_Xan_dh_C2)PF03450(CO_deh_flav_C) | 4 | GLU A 742GLU A 938THR A 937LEU A 930 | None | 1.26A | 5hm8B-5epgA:undetectable | 5hm8B-5epgA:16.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fqe | BETA-N-ACETYLGALACTOSAMINIDASE (Clostridiumperfringens) |
PF13320(DUF4091) | 4 | GLU A 172THR A 173GLU A 521LEU A 165 | NoneNone BR A1589 ( 4.7A)None | 1.15A | 5hm8B-5fqeA:2.5 | 5hm8B-5fqeA:21.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n1q | METHYL-COENZYME MREDUCTASE III FROMMETHANOTHERMOCOCCUSTHERMOLITHOTROPHICUSSUBUNIT BETA (Methanothermococcusthermolithotrophicus) |
PF02241(MCR_beta)PF02783(MCR_beta_N) | 4 | GLU B 225THR B 221GLU B 219LEU B 178 | None | 1.21A | 5hm8B-5n1qB:undetectable | 5hm8B-5n1qB:23.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n28 | METHYL-COENZYME MREDUCTASE, BETASUBUNIT (Methanotorrisformicicus) |
PF02241(MCR_beta)PF02783(MCR_beta_N) | 4 | GLU B 225THR B 221GLU B 219LEU B 178 | None | 1.20A | 5hm8B-5n28B:undetectable | 5hm8B-5n28B:23.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n4w | CULLIN-2 (Homo sapiens) |
PF00888(Cullin)PF10557(Cullin_Nedd8) | 4 | GLU A 166GLU A 214THR A 215LEU A 254 | None | 1.13A | 5hm8B-5n4wA:undetectable | 5hm8B-5n4wA:21.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o6b | ATP-DEPENDENT DNAHELICASE PIF1 (Saccharomycescerevisiae) |
no annotation | 4 | GLU A 739GLU A 443THR A 440LEU A 428 | None | 1.16A | 5hm8B-5o6bA:undetectable | 5hm8B-5o6bA:11.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5szu | ACYL-COA HYDROLASE (Neisseriameningitidis) |
PF03061(4HBT) | 4 | GLU A 140GLU A 89THR A 113LEU A 150 | NoneNoneNoneCOA A 201 (-4.4A) | 1.12A | 5hm8B-5szuA:undetectable | 5hm8B-5szuA:15.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t8u | LIPOATE-PROTEINLIGASE 1 (Plasmodiumfalciparum) |
PF03099(BPL_LplA_LipB)PF10437(Lip_prot_lig_C) | 4 | GLU A 239GLU A 233THR A 137LEU A 66 | None | 1.20A | 5hm8B-5t8uA:undetectable | 5hm8B-5t8uA:21.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5um8 | GLYCOPROTEIN GP120 (Humanimmunodeficiencyvirus 1) |
PF00516(GP120) | 4 | GLU G 49THR G 50GLU G 490LEU G 226 | None | 1.10A | 5hm8B-5um8G:undetectable | 5hm8B-5um8G:21.72 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5utu | ADENOSYLHOMOCYSTEINASE (Cryptosporidiumparvum) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | GLU A 57THR A 58GLU A 211THR A 212LEU A 401 | SAH A 502 (-3.7A)SAH A 502 (-4.2A)SAH A 502 (-3.8A)NAD A 501 ( 4.1A)NAD A 501 (-4.1A) | 0.46A | 5hm8B-5utuA:62.7 | 5hm8B-5utuA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5v96 | S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE (Naegleriafowleri) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | GLU A 63THR A 64GLU A 197THR A 198LEU A 386 | ADN A 502 (-3.6A)ADN A 502 (-4.4A)ADN A 502 (-3.5A)NAD A 501 ( 2.9A)NAD A 501 (-3.9A) | 0.19A | 5hm8B-5v96A:55.5 | 5hm8B-5v96A:54.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vrb | TRANSKETOLASE (Neisseriagonorrhoeae) |
PF00456(Transketolase_N)PF02779(Transket_pyr)PF02780(Transketolase_C) | 4 | GLU A 557THR A 554THR A 478LEU A 432 | EDO A 701 (-3.8A)NoneNoneNone | 1.19A | 5hm8B-5vrbA:2.8 | 5hm8B-5vrbA:22.09 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5w4b | ADENOSYLHOMOCYSTEINASE (Homo sapiens) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 4 | GLU A 59THR A 60GLU A 156THR A 157 | 9W4 A 502 (-3.8A)NoneNoneNone | 0.77A | 5hm8B-5w4bA:44.5 | 5hm8B-5w4bA:48.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xex | POLYRIBONUCLEOTIDENUCLEOTIDYLTRANSFERASE (Staphylococcusaureus) |
no annotation | 4 | GLU A 504THR A 502GLU A 198LEU A 175 | None | 1.25A | 5hm8B-5xexA:undetectable | 5hm8B-5xexA:21.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xgc | RAP1 GTPASE-GDPDISSOCIATIONSTIMULATOR 1 (Homo sapiens) |
PF00514(Arm) | 4 | GLU A 239THR A 242GLU A 197LEU A 179 | None | 1.08A | 5hm8B-5xgcA:undetectable | 5hm8B-5xgcA:24.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ze8 | CYTOCHROME C552 (Thermochromatiumtepidum) |
no annotation | 4 | GLU A 382THR A 383GLU A 385LEU A 323 | None | 1.16A | 5hm8B-5ze8A:undetectable | 5hm8B-5ze8A:10.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bhu | MULTIDRUGRESISTANCE-ASSOCIATED PROTEIN 1 (Bos taurus) |
no annotation | 4 | GLU A1156GLU A 760THR A 759LEU A 768 | None | 0.96A | 5hm8B-6bhuA:undetectable | 5hm8B-6bhuA:0.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c66 | CRISPR-ASSOCIATEDHELICASE, CAS3FAMILYCRISPR-ASSOCIATEDPROTEIN, CSE1 FAMILY (Thermobifidafusca) |
no annotation | 4 | GLU G 106THR G 89THR A 541LEU A 421 | None | 1.23A | 5hm8B-6c66G:undetectable | 5hm8B-6c66G:10.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cpl | HLA CLASS IIHISTOCOMPATIBILITYANTIGEN, DR ALPHACHAIN (Homo sapiens) |
no annotation | 4 | GLU A 158THR A 157GLU A 179LEU A 105 | None | 1.24A | 5hm8B-6cplA:undetectable | 5hm8B-6cplA:11.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6eno | DEHYDRATASE FAMILYPROTEIN (Carboxydothermushydrogenoformans) |
no annotation | 4 | GLU A 140THR A 141GLU A 179LEU A 336 | None | 1.20A | 5hm8B-6enoA:undetectable | 5hm8B-6enoA:11.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f3m | - (-) |
no annotation | 4 | THR B 66GLU B 164THR B 165LEU B 373 | ADN B 502 (-4.6A)ADN B 502 (-3.6A)NAD B 501 ( 2.8A)NAD B 501 ( 3.9A) | 0.21A | 5hm8B-6f3mB:49.3 | 5hm8B-6f3mB:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f85 | CYTOCHROME P450CYP260A1 (Sorangiumcellulosum) |
no annotation | 4 | GLU A 153THR A 151GLU A 232THR A 233 | NoneNoneNoneHIS A 502 ( 3.5A) | 1.16A | 5hm8B-6f85A:undetectable | 5hm8B-6f85A:9.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6gbn | - (-) |
no annotation | 4 | THR A 61GLU A 159THR A 160LEU A 347 | ADN A 501 (-4.6A)ADN A 501 (-3.9A)NAD A 502 ( 2.8A)NAD A 502 (-3.9A) | 0.22A | 5hm8B-6gbnA:27.3 | 5hm8B-6gbnA:undetectable |