SIMILAR PATTERNS OF AMINO ACIDS FOR 5HKG_A_RAPA201_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bhe | POLYGALACTURONASE (Pectobacteriumcarotovorum) |
PF00295(Glyco_hydro_28) | 5 | ASP A 224VAL A 267ILE A 242ILE A 204PHE A 247 | None | 1.15A | 5hkgA-1bheA:undetectable | 5hkgA-1bheA:15.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fd9 | PROTEIN (MACROPHAGEINFECTIVITYPOTENTIATOR PROTEIN) (Legionellapneumophila) |
PF00254(FKBP_C)PF01346(FKBP_N) | 6 | ASP A 142PHE A 153ILE A 159TYR A 185ILE A 194PHE A 202 | None | 1.14A | 5hkgA-1fd9A:15.8 | 5hkgA-1fd9A:23.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fd9 | PROTEIN (MACROPHAGEINFECTIVITYPOTENTIATOR PROTEIN) (Legionellapneumophila) |
PF00254(FKBP_C)PF01346(FKBP_N) | 7 | TYR A 131ASP A 142VAL A 158ILE A 159TYR A 185ILE A 194PHE A 202 | None | 0.55A | 5hkgA-1fd9A:15.8 | 5hkgA-1fd9A:23.20 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1fkk | FK506 BINDINGPROTEIN (Bos taurus) |
PF00254(FKBP_C) | 7 | TYR A 26ASP A 37GLU A 54TYR A 82HIS A 87ILE A 91PHE A 99 | None | 0.92A | 5hkgA-1fkkA:21.8 | 5hkgA-1fkkA:85.05 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1fkk | FK506 BINDINGPROTEIN (Bos taurus) |
PF00254(FKBP_C) | 9 | TYR A 26ASP A 37PHE A 46GLU A 54VAL A 55ILE A 56TYR A 82ILE A 91PHE A 99 | None | 0.55A | 5hkgA-1fkkA:21.8 | 5hkgA-1fkkA:85.05 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1fkk | FK506 BINDINGPROTEIN (Bos taurus) |
PF00254(FKBP_C) | 5 | TYR A 26PHE A 46GLU A 54VAL A 55ILE A 90 | None | 1.13A | 5hkgA-1fkkA:21.8 | 5hkgA-1fkkA:85.05 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1jvw | MACROPHAGEINFECTIVITYPOTENTIATOR (Trypanosomacruzi) |
PF00254(FKBP_C) | 7 | TYR A 92ASP A 103VAL A 119ILE A 120TYR A 146ILE A 155PHE A 163 | None | 0.65A | 5hkgA-1jvwA:15.0 | 5hkgA-1jvwA:40.48 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1jvw | MACROPHAGEINFECTIVITYPOTENTIATOR (Trypanosomacruzi) |
PF00254(FKBP_C) | 7 | TYR A 92GLU A 118VAL A 119ILE A 120TYR A 146ILE A 155PHE A 163 | None | 0.47A | 5hkgA-1jvwA:15.0 | 5hkgA-1jvwA:40.48 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1jvw | MACROPHAGEINFECTIVITYPOTENTIATOR (Trypanosomacruzi) |
PF00254(FKBP_C) | 6 | TYR A 92PHE A 114ILE A 120TYR A 146ILE A 155PHE A 163 | None | 0.96A | 5hkgA-1jvwA:15.0 | 5hkgA-1jvwA:40.48 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1kt1 | FK506-BINDINGPROTEIN FKBP51 (Saimiriboliviensis) |
PF00254(FKBP_C)PF00515(TPR_1)PF13181(TPR_8) | 5 | TYR A 57PHE A 77ILE A 87TYR A 113PHE A 130 | None | 0.82A | 5hkgA-1kt1A:15.5 | 5hkgA-1kt1A:40.85 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1kt1 | FK506-BINDINGPROTEIN FKBP51 (Saimiriboliviensis) |
PF00254(FKBP_C)PF00515(TPR_1)PF13181(TPR_8) | 5 | TYR A 57PHE A 77VAL A 86TYR A 113PHE A 130 | None | 0.72A | 5hkgA-1kt1A:15.5 | 5hkgA-1kt1A:40.85 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1n1a | FKBP52 (Homo sapiens) |
PF00254(FKBP_C) | 9 | TYR A 57ASP A 68PHE A 77GLU A 85VAL A 86ILE A 87TYR A 113ILE A 122PHE A 130 | None | 0.76A | 5hkgA-1n1aA:17.7 | 5hkgA-1n1aA:38.57 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1pbk | FKBP25 (Homo sapiens) |
PF00254(FKBP_C) | 7 | TYR A 135ASP A 146VAL A 171ILE A 172TYR A 198ILE A 208PHE A 216 | RAP A 225 (-3.9A)RAP A 225 (-3.0A)RAP A 225 (-3.5A)RAP A 225 (-3.9A)RAP A 225 (-4.6A)RAP A 225 ( 4.9A)None | 0.38A | 5hkgA-1pbkA:19.1 | 5hkgA-1pbkA:42.50 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1q6h | FKBP-TYPEPEPTIDYL-PROLYLCIS-TRANS ISOMERASEFKPA (Escherichiacoli) |
PF00254(FKBP_C)PF01346(FKBP_N) | 7 | TYR A 146ASP A 157VAL A 173ILE A 174TYR A 200ILE A 208PHE A 216 | None | 0.57A | 5hkgA-1q6hA:15.7 | 5hkgA-1q6hA:30.99 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1r9h | FK506 BINDINGPROTEIN FAMILY (Caenorhabditiselegans) |
PF00254(FKBP_C) | 8 | TYR A 40ASP A 51PHE A 60VAL A 69ILE A 70TYR A 96ILE A 105PHE A 113 | None | 0.65A | 5hkgA-1r9hA:19.7 | 5hkgA-1r9hA:38.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ry2 | ACETYL-COENZYME ASYNTHETASE 1 (Saccharomycescerevisiae) |
PF00501(AMP-binding)PF13193(AMP-binding_C)PF16177(ACAS_N) | 5 | PHE A 349VAL A 466ILE A 465TYR A 454ILE A 458 | None | 1.04A | 5hkgA-1ry2A:undetectable | 5hkgA-1ry2A:12.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t11 | TRIGGER FACTOR (Vibrio cholerae) |
PF00254(FKBP_C)PF05697(Trigger_N)PF05698(Trigger_C) | 5 | PHE A 185ILE A 195PHE A 198TYR A 221PHE A 233 | None | 0.86A | 5hkgA-1t11A:undetectable | 5hkgA-1t11A:13.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tq4 | INTERFERON-INDUCIBLEGTPASE (Mus musculus) |
PF05049(IIGP) | 5 | GLU A 219ILE A 222PHE A 217ILE A 171PHE A 180 | None | 1.18A | 5hkgA-1tq4A:undetectable | 5hkgA-1tq4A:13.02 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1u79 | FKBP-TYPEPEPTIDYL-PROLYLCIS-TRANS ISOMERASE3 (Arabidopsisthaliana) |
PF00254(FKBP_C) | 8 | TYR A 37ASP A 48GLU A 65VAL A 66ILE A 67TYR A 99ILE A 113PHE A 121 | None | 0.55A | 5hkgA-1u79A:17.1 | 5hkgA-1u79A:37.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uf2 | OUTER CAPSID PROTEINP8 (Rice dwarfvirus) |
no annotation | 5 | PHE P 414ILE P 100PHE P 99TYR P 80PHE P 71 | None | 1.05A | 5hkgA-1uf2P:undetectable | 5hkgA-1uf2P:15.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xcr | HYPOTHETICAL PROTEINPTD012 (Homo sapiens) |
PF08925(DUF1907) | 5 | GLU A 233VAL A 234HIS A 239VAL A 133ILE A 218 | None | 0.94A | 5hkgA-1xcrA:undetectable | 5hkgA-1xcrA:18.96 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1yat | FK506 BINDINGPROTEIN (Saccharomycescerevisiae) |
PF00254(FKBP_C) | 8 | TYR A 26ASP A 37PHE A 46VAL A 55ILE A 56TYR A 82ILE A 91PHE A 99 | FK5 A 108 ( 4.0A)FK5 A 108 ( 3.3A)FK5 A 108 ( 4.0A)FK5 A 108 ( 3.4A)FK5 A 108 ( 3.7A)FK5 A 108 ( 4.7A)NoneNone | 0.44A | 5hkgA-1yatA:20.1 | 5hkgA-1yatA:55.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2eb1 | ENDORIBONUCLEASEDICER (Homo sapiens) |
PF00636(Ribonuclease_3) | 5 | TYR A 99PHE A 11ILE A 153VAL A 115ILE A 111 | None | 1.14A | 5hkgA-2eb1A:undetectable | 5hkgA-2eb1A:18.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fnc | MALTOSE ABCTRANSPORTER,PERIPLASMICMALTOSE-BINDINGPROTEIN (Thermotogamaritima) |
PF13416(SBP_bac_8) | 5 | TYR A 213ASP A 217VAL A 113ILE A 229PHE A 159 | MLR A2913 ( 3.8A)NoneNoneNoneMLR A2913 (-4.6A) | 1.04A | 5hkgA-2fncA:undetectable | 5hkgA-2fncA:14.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ip1 | TRYPTOPHANYL-TRNASYNTHETASE (Saccharomycescerevisiae) |
PF00579(tRNA-synt_1b) | 5 | TYR A 401ILE A 175PHE A 404HIS A 173PHE A 405 | None | 1.13A | 5hkgA-2ip1A:undetectable | 5hkgA-2ip1A:14.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iv8 | AP-2 COMPLEX SUBUNITBETA-1 (Homo sapiens) |
PF02883(Alpha_adaptinC2)PF09066(B2-adapt-app_C) | 5 | PHE A 762GLU A 922VAL A 923ILE A 927PHE A 826 | None | 0.94A | 5hkgA-2iv8A:undetectable | 5hkgA-2iv8A:18.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iwa | GLUTAMINECYCLOTRANSFERASE (Carica papaya) |
PF05096(Glu_cyclase_2) | 5 | ASP A 194VAL A 33ILE A 255PHE A 253ILE A 196 | None | 1.06A | 5hkgA-2iwaA:undetectable | 5hkgA-2iwaA:19.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iwa | GLUTAMINECYCLOTRANSFERASE (Carica papaya) |
PF05096(Glu_cyclase_2) | 5 | ASP A 194VAL A 33ILE A 255PHE A 253ILE A 210 | None | 1.19A | 5hkgA-2iwaA:undetectable | 5hkgA-2iwaA:19.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j0a | BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASEMANIC FRINGE (Mus musculus) |
PF02434(Fringe) | 5 | ASP A 231ILE A 203PHE A 138ILE A 238PHE A 127 | None | 1.15A | 5hkgA-2j0aA:undetectable | 5hkgA-2j0aA:16.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nnj | CYTOCHROME P450 2C8 (Homo sapiens) |
PF00067(p450) | 5 | PHE A 54VAL A 67PHE A 65VAL A 370ILE A 381 | None | 1.19A | 5hkgA-2nnjA:undetectable | 5hkgA-2nnjA:14.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o04 | PECTATE LYASE (Bacillussubtilis) |
PF00544(Pec_lyase_C) | 5 | VAL A 152ILE A 154VAL A 35ILE A 58PHE A 145 | None | 1.17A | 5hkgA-2o04A:undetectable | 5hkgA-2o04A:14.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p17 | PIRIN-LIKE PROTEIN (Geobacilluskaustophilus) |
PF02678(Pirin)PF05726(Pirin_C) | 5 | TYR A 240GLU A 61VAL A 116PHE A 39PHE A 191 | None | 1.17A | 5hkgA-2p17A:undetectable | 5hkgA-2p17A:20.16 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2pbc | FK506-BINDINGPROTEIN 2 (Homo sapiens) |
PF00254(FKBP_C) | 8 | TYR A 56ASP A 67PHE A 76VAL A 85ILE A 86TYR A 112ILE A 121PHE A 129 | PEG A 201 (-4.4A)NonePEG A 201 ( 3.9A)PEG A 201 (-3.6A)PEG A 201 (-3.8A)NoneNoneNone | 0.91A | 5hkgA-2pbcA:15.2 | 5hkgA-2pbcA:42.06 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2vn1 | 70 KDAPEPTIDYLPROLYLISOMERASE (Plasmodiumfalciparum) |
PF00254(FKBP_C) | 9 | TYR A 44ASP A 56PHE A 65GLU A 73VAL A 74ILE A 75TYR A 101ILE A 110PHE A 118 | FK5 A 501 (-4.1A)FK5 A 501 (-3.4A)FK5 A 501 (-4.1A)NoneFK5 A 501 (-3.5A)FK5 A 501 (-4.3A)FK5 A 501 (-4.7A)NoneFK5 A 501 (-4.8A) | 0.53A | 5hkgA-2vn1A:19.5 | 5hkgA-2vn1A:37.98 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2y78 | PEPTIDYL-PROLYLCIS-TRANS ISOMERASE (Burkholderiapseudomallei) |
PF00254(FKBP_C) | 8 | TYR A 33ASP A 44PHE A 53VAL A 62ILE A 63TYR A 89ILE A 98PHE A 106 | None | 0.68A | 5hkgA-2y78A:17.8 | 5hkgA-2y78A:51.89 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2y78 | PEPTIDYL-PROLYLCIS-TRANS ISOMERASE (Burkholderiapseudomallei) |
PF00254(FKBP_C) | 8 | TYR A 33ASP A 44VAL A 62ILE A 63TYR A 89VAL A 97ILE A 98PHE A 106 | None | 0.83A | 5hkgA-2y78A:17.8 | 5hkgA-2y78A:51.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zj8 | PUTATIVE SKI2-TYPEHELICASE (Pyrococcusfuriosus) |
PF00270(DEAD)PF00271(Helicase_C)PF14520(HHH_5) | 5 | PHE A 436GLU A 160VAL A 161ILE A 136PHE A 425 | None | 1.00A | 5hkgA-2zj8A:undetectable | 5hkgA-2zj8A:9.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zy2 | L-ASPARTATE4-CARBOXYLYASE (Pseudomonas sp.ATCC 19121) |
PF00155(Aminotran_1_2) | 5 | ASP A 286PHE A 204ILE A 210ILE A 181PHE A 250 | PLP A 900 (-3.2A)PLP A 900 (-4.2A)NoneNoneNone | 0.99A | 5hkgA-2zy2A:undetectable | 5hkgA-2zy2A:12.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b54 | NUCLEOSIDEDIPHOSPHATE KINASE (Saccharomycescerevisiae) |
PF00334(NDK) | 5 | PHE A 135VAL A 78PHE A 9VAL A 22ILE A 25 | None | 1.16A | 5hkgA-3b54A:undetectable | 5hkgA-3b54A:25.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dde | TENA/THI-4 PROTEIN,DOMAIN OF UNKNOWNFUNCTION WITH A HEMEOXYGENASE-LIKE FOLD (Shewanelladenitrificans) |
PF14518(Haem_oxygenas_2) | 5 | TYR A 43VAL A 30ILE A 27PHE A 26VAL A 142 | None | 1.18A | 5hkgA-3ddeA:undetectable | 5hkgA-3ddeA:21.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ii6 | DNA LIGASE 4 (Homo sapiens) |
PF00533(BRCT)PF11411(DNA_ligase_IV) | 6 | GLU X 660ILE X 682PHE X 685VAL X 721ILE X 701PHE X 730 | None | 1.07A | 5hkgA-3ii6X:undetectable | 5hkgA-3ii6X:17.49 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3o5d | PEPTIDYL-PROLYLCIS-TRANS ISOMERASEFKBP5 (Homo sapiens) |
PF00254(FKBP_C) | 8 | TYR A 57ASP A 68PHE A 77VAL A 86ILE A 87TYR A 113ILE A 122PHE A 130 | None | 0.70A | 5hkgA-3o5dA:18.4 | 5hkgA-3o5dA:31.64 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3o5e | PEPTIDYL-PROLYLCIS-TRANS ISOMERASEFKBP5 (Homo sapiens) |
PF00254(FKBP_C) | 8 | TYR A 57ASP A 68PHE A 77VAL A 86ILE A 87TYR A 113ILE A 122PHE A 130 | None | 0.77A | 5hkgA-3o5eA:18.6 | 5hkgA-3o5eA:37.50 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3pa7 | 70 KDAPEPTIDYLPROLYLISOMERASE, PUTATIVE (Plasmodiumvivax) |
PF00254(FKBP_C) | 8 | TYR A 43ASP A 55PHE A 64GLU A 72VAL A 73ILE A 74ILE A 109PHE A 117 | None | 0.69A | 5hkgA-3pa7A:19.0 | 5hkgA-3pa7A:41.96 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3pa7 | 70 KDAPEPTIDYLPROLYLISOMERASE, PUTATIVE (Plasmodiumvivax) |
PF00254(FKBP_C) | 8 | TYR A 43PHE A 64GLU A 72VAL A 73ILE A 74TYR A 100ILE A 109PHE A 117 | None | 0.49A | 5hkgA-3pa7A:19.0 | 5hkgA-3pa7A:41.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sqw | ATP-DEPENDENT RNAHELICASE MSS116,MITOCHONDRIAL (Saccharomycescerevisiae) |
PF00270(DEAD)PF00271(Helicase_C) | 5 | ASP A 343VAL A 498ILE A 497TYR A 460ILE A 464 | None | 1.12A | 5hkgA-3sqwA:undetectable | 5hkgA-3sqwA:13.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w9i | MULTIDRUG RESISTANCEPROTEIN MEXB (Pseudomonasaeruginosa) |
PF00873(ACR_tran) | 5 | GLU A 528VAL A 531ILE A 534PHE A1018HIS A 537 | None | 1.15A | 5hkgA-3w9iA:undetectable | 5hkgA-3w9iA:6.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wl4 | UNCHARACTERIZEDPROTEIN (Pyrococcusfuriosus) |
PF02585(PIG-L) | 5 | PHE A 28VAL A 252ILE A 187PHE A 186ILE A 37 | NoneNoneHEZ A 317 ( 4.3A)NoneNone | 1.18A | 5hkgA-3wl4A:undetectable | 5hkgA-3wl4A:16.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ay2 | PROBABLEATP-DEPENDENT RNAHELICASE DDX58 (Homo sapiens) |
PF00271(Helicase_C)PF04851(ResIII)PF11648(RIG-I_C-RD) | 5 | VAL A 405PHE A 371VAL A 338ILE A 344PHE A 296 | None | 1.16A | 5hkgA-4ay2A:undetectable | 5hkgA-4ay2A:10.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b0n | POLYKETIDE SYNTHASEIII (Ectocarpussiliculosus) |
PF00195(Chal_sti_synt_N)PF02797(Chal_sti_synt_C) | 5 | PHE A 230VAL A 65PHE A 98ILE A 88PHE A 93 | ACD A1416 (-4.7A)NoneACD A1416 (-4.1A)NoneACD A1416 ( 4.5A) | 1.18A | 5hkgA-4b0nA:undetectable | 5hkgA-4b0nA:12.32 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4bf8 | FPR4 (Saccharomycescerevisiae) |
PF00254(FKBP_C) | 5 | TYR A 313ASP A 324PHE A 332ILE A 342PHE A 384 | None | 0.91A | 5hkgA-4bf8A:15.9 | 5hkgA-4bf8A:36.67 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4bf8 | FPR4 (Saccharomycescerevisiae) |
PF00254(FKBP_C) | 7 | TYR A 313ASP A 324VAL A 341ILE A 342TYR A 368ILE A 376PHE A 384 | None | 0.88A | 5hkgA-4bf8A:15.9 | 5hkgA-4bf8A:36.67 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4bf8 | FPR4 (Saccharomycescerevisiae) |
PF00254(FKBP_C) | 7 | TYR A 313GLU A 340VAL A 341ILE A 342TYR A 368ILE A 376PHE A 384 | None | 1.24A | 5hkgA-4bf8A:15.9 | 5hkgA-4bf8A:36.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4db4 | ATP-DEPENDENT RNAHELICASE MSS116,MITOCHONDRIAL (Saccharomycescerevisiae) |
PF00271(Helicase_C) | 5 | ASP A 343VAL A 498ILE A 497TYR A 460ILE A 464 | None | 1.14A | 5hkgA-4db4A:undetectable | 5hkgA-4db4A:16.92 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4dip | PEPTIDYL-PROLYLCIS-TRANS ISOMERASEFKBP14 (Homo sapiens) |
PF00254(FKBP_C) | 5 | TYR A 52GLU A 83TYR A 111ILE A 119PHE A 127 | None | 0.75A | 5hkgA-4dipA:16.8 | 5hkgA-4dipA:34.71 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4dz3 | PEPTIDYL-PROLYLCIS-TRANS ISOMERASE (Burkholderiapseudomallei) |
PF00254(FKBP_C) | 8 | TYR A 33ASP A 44PHE A 53VAL A 62ILE A 63TYR A 89ILE A 98PHE A 106 | FK5 A 201 ( 3.9A)FK5 A 201 (-3.5A)FK5 A 201 (-4.1A)FK5 A 201 ( 3.6A)FK5 A 201 (-3.8A)FK5 A 201 (-4.7A)NoneFK5 A 201 (-4.8A) | 0.40A | 5hkgA-4dz3A:18.6 | 5hkgA-4dz3A:48.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4emy | AMINOTRANSFERASECLASS I AND II (Anaerococcusprevotii) |
PF00155(Aminotran_1_2) | 5 | VAL A 250ILE A 273PHE A 241VAL A 85ILE A 86 | None | 0.97A | 5hkgA-4emyA:undetectable | 5hkgA-4emyA:15.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f3e | CASA (Thermusthermophilus) |
PF09481(CRISPR_Cse1) | 5 | PHE A 303GLU A 357VAL A 341PHE A 188ILE A 337 | None | 1.13A | 5hkgA-4f3eA:undetectable | 5hkgA-4f3eA:13.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fqg | TRANSCRIPTIONELONGATION REGULATOR1 (Homo sapiens) |
PF01846(FF) | 5 | TYR A 116ASP A 75GLU A 88VAL A 89ILE A 93 | None | 1.14A | 5hkgA-4fqgA:undetectable | 5hkgA-4fqgA:19.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g76 | PHOSPHODIESTERASE (Pseudomonasaeruginosa) |
PF14859(Colicin_M) | 5 | VAL A 211ILE A 277PHE A 161TYR A 275PHE A 137 | None | 1.14A | 5hkgA-4g76A:undetectable | 5hkgA-4g76A:15.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gnk | 1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATEPHOSPHODIESTERASEBETA-3 (Homo sapiens) |
PF00168(C2)PF00387(PI-PLC-Y)PF00388(PI-PLC-X)PF09279(EF-hand_like) | 5 | ASP B 851GLU B 717VAL B 718ILE B 719TYR B 847 | None | 0.91A | 5hkgA-4gnkB:undetectable | 5hkgA-4gnkB:7.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h19 | MANDELATE RACEMASE (Agrobacteriumfabrum) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | ASP A 144PHE A 168VAL A 342ILE A 340ILE A 332 | NoneNoneNoneNone CL A 404 (-4.3A) | 1.19A | 5hkgA-4h19A:undetectable | 5hkgA-4h19A:14.78 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4iqc | PEPTIDYL-PROLYLCIS-TRANS ISOMERASEFKBP1B (Homo sapiens) |
PF00254(FKBP_C) | 11 | TYR A 26ASP A 37PHE A 46GLU A 54ILE A 56PHE A 59TYR A 82HIS A 87VAL A 90ILE A 91PHE A 99 | None | 0.74A | 5hkgA-4iqcA:22.1 | 5hkgA-4iqcA:98.13 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4iqc | PEPTIDYL-PROLYLCIS-TRANS ISOMERASEFKBP1B (Homo sapiens) |
PF00254(FKBP_C) | 11 | TYR A 26PHE A 46GLU A 54VAL A 55ILE A 56PHE A 59TYR A 82HIS A 87VAL A 90ILE A 91PHE A 99 | None | 0.65A | 5hkgA-4iqcA:22.1 | 5hkgA-4iqcA:98.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k0x | BETA-LACTAMASE (Acinetobacterbaumannii) |
PF00905(Transpeptidase) | 6 | PHE A 81VAL A 147ILE A 150PHE A 152VAL A 195PHE A 180 | None | 0.91A | 5hkgA-4k0xA:undetectable | 5hkgA-4k0xA:16.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4law | PEPTIDYL-PROLYLCIS-TRANS ISOMERASEFKBP4 (Homo sapiens) |
PF00254(FKBP_C) | 7 | TYR A 57ASP A 68PHE A 77GLU A 85VAL A 86ILE A 87PHE A 130 | NoneNoneNoneNoneDMS A 304 (-3.5A)DMS A 304 (-3.8A)DMS A 304 (-4.3A) | 0.53A | 5hkgA-4lawA:19.1 | 5hkgA-4lawA:23.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4law | PEPTIDYL-PROLYLCIS-TRANS ISOMERASEFKBP4 (Homo sapiens) |
PF00254(FKBP_C) | 8 | TYR A 57PHE A 77GLU A 85VAL A 86ILE A 87TYR A 113ILE A 122PHE A 130 | NoneNoneNoneDMS A 304 (-3.5A)DMS A 304 (-3.8A)NoneNoneDMS A 304 (-4.3A) | 0.57A | 5hkgA-4lawA:19.1 | 5hkgA-4lawA:23.17 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4msp | PEPTIDYL-PROLYLCIS-TRANS ISOMERASEFKBP14 (Homo sapiens) |
PF00254(FKBP_C)PF13499(EF-hand_7) | 5 | TYR A 33GLU A 64TYR A 92ILE A 100PHE A 108 | None | 0.62A | 5hkgA-4mspA:17.4 | 5hkgA-4mspA:30.56 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4nnr | PEPTIDYL-PROLYLCIS-TRANS ISOMERASEFKBP2 (Homo sapiens) |
PF00254(FKBP_C) | 8 | TYR A 56ASP A 67PHE A 76VAL A 85ILE A 86TYR A 112ILE A 121PHE A 129 | FK5 A 201 (-4.1A)FK5 A 201 (-3.4A)FK5 A 201 (-4.0A)FK5 A 201 (-3.4A)FK5 A 201 (-3.8A)FK5 A 201 (-4.5A)NoneFK5 A 201 (-4.9A) | 0.44A | 5hkgA-4nnrA:15.7 | 5hkgA-4nnrA:35.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4odm | PEPTIDYL-PROLYLCIS-TRANS ISOMERASESLYD (Thermusthermophilus) |
PF00254(FKBP_C) | 5 | TYR A 13ASP A 23ILE A 37HIS A 119PHE A 128 | None | 0.77A | 5hkgA-4odmA:12.0 | 5hkgA-4odmA:24.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4odm | PEPTIDYL-PROLYLCIS-TRANS ISOMERASESLYD (Thermusthermophilus) |
PF00254(FKBP_C) | 5 | TYR A 13ASP A 23ILE A 37TYR A 63PHE A 128 | None | 0.49A | 5hkgA-4odmA:12.0 | 5hkgA-4odmA:24.12 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4odr | PEPTIDYL-PROLYLCIS-TRANS ISOMERASESLYD,PEPTIDYL-PROLYLCIS-TRANS ISOMERASEFKBP1A CHIMERA (Homo sapiens;Thermusthermophilus) |
PF00254(FKBP_C) | 7 | TYR A 13ASP A 23ILE A 37TYR A 63HIS A 68ILE A 72PHE A 80 | FK5 A 201 ( 3.6A)FK5 A 201 (-3.6A)FK5 A 201 (-3.9A)FK5 A 201 (-4.4A)NoneNoneFK5 A 201 ( 4.8A) | 0.61A | 5hkgA-4odrA:13.6 | 5hkgA-4odrA:32.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pbc | D-AMINO ACIDAMINOTRANSFERASE (Burkholderiacenocepacia) |
PF01063(Aminotran_4) | 5 | ASP A 261ILE A 252PHE A 219VAL A 283ILE A 263 | None | 1.18A | 5hkgA-4pbcA:undetectable | 5hkgA-4pbcA:15.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qj4 | 1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATEPHOSPHODIESTERASEBETA-3 (Homo sapiens) |
PF00168(C2)PF00387(PI-PLC-Y)PF00388(PI-PLC-X)PF09279(EF-hand_like) | 5 | GLU B 778VAL B 732ILE B 840VAL B 813ILE B 816 | None | 0.82A | 5hkgA-4qj4B:undetectable | 5hkgA-4qj4B:9.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qku | HYDROLASE (Burkholderiacenocepacia) |
PF01557(FAA_hydrolase)PF09298(FAA_hydrolase_N) | 5 | VAL A 221ILE A 220PHE A 219VAL A 181ILE A 274 | None | 1.16A | 5hkgA-4qkuA:undetectable | 5hkgA-4qkuA:12.74 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4r0x | PEPTIDYL-PROLYLCIS-TRANS ISOMERASEFKBP5 (Homo sapiens) |
PF00254(FKBP_C) | 7 | TYR A 57ASP A 68PHE A 77VAL A 86ILE A 87TYR A 113PHE A 130 | None | 0.82A | 5hkgA-4r0xA:18.9 | 5hkgA-4r0xA:43.44 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4r0x | PEPTIDYL-PROLYLCIS-TRANS ISOMERASEFKBP5 (Homo sapiens) |
PF00254(FKBP_C) | 7 | TYR A 57PHE A 77VAL A 86ILE A 87TYR A 113ILE A 122PHE A 130 | None | 0.73A | 5hkgA-4r0xA:18.9 | 5hkgA-4r0xA:43.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r84 | SIALYLTRANSFERASE0160 (Photobacteriumdamselae) |
PF11477(PM0188) | 5 | VAL A 460ILE A 459PHE A 458TYR A 448ILE A 451 | None | 1.07A | 5hkgA-4r84A:undetectable | 5hkgA-4r84A:12.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a11 | THIOCYANATE FORMINGPROTEIN (Thlaspi arvense) |
PF01344(Kelch_1) | 5 | VAL A 142PHE A 91HIS A 139ILE A 166PHE A 103 | None | 1.01A | 5hkgA-5a11A:undetectable | 5hkgA-5a11A:15.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a6f | GATING RING OFPOTASSIUM CHANNELSUBFAMILY T MEMBER 1 (Gallus gallus) |
PF03493(BK_channel_a) | 5 | TYR C 467ASP C 483PHE C 956VAL C 353PHE C 433 | None | 1.06A | 5hkgA-5a6fC:undetectable | 5hkgA-5a6fC:8.57 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5b8i | PEPTIDYL-PROLYLCIS-TRANS ISOMERASE (Coccidioidesimmitis) |
PF00254(FKBP_C) | 8 | TYR C 36ASP C 56PHE C 64VAL C 73ILE C 74TYR C 100ILE C 109PHE C 117 | FK5 C 201 (-4.1A)FK5 C 201 ( 3.8A)FK5 C 201 (-3.8A)FK5 C 201 (-3.5A)FK5 C 201 (-3.8A)FK5 C 201 (-4.5A)NoneFK5 C 201 (-4.7A) | 0.36A | 5hkgA-5b8iC:19.4 | 5hkgA-5b8iC:44.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cwb | DESIGNED HELICALREPEAT PROTEIN (syntheticconstruct) |
no annotation | 5 | GLU A 193VAL A 192ILE A 139VAL A 168ILE A 167 | None | 1.14A | 5hkgA-5cwbA:undetectable | 5hkgA-5cwbA:17.87 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5i7p | PEPTIDYL-PROLYLCIS-TRANS ISOMERASEFKBP1A,FKBP-TYPEPEPTIDYL-PROLYLCIS-TRANS ISOMERASESLYD,PEPTIDYL-PROLYLCIS-TRANS ISOMERASEFKBP1A (Escherichiacoli;Homo sapiens) |
PF00254(FKBP_C) | 7 | ASP A 37GLU A 54VAL A 55ILE A 56TYR A 82HIS A 137PHE A 146 | None | 0.97A | 5hkgA-5i7pA:20.0 | 5hkgA-5i7pA:52.60 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5i7p | PEPTIDYL-PROLYLCIS-TRANS ISOMERASEFKBP1A,FKBP-TYPEPEPTIDYL-PROLYLCIS-TRANS ISOMERASESLYD,PEPTIDYL-PROLYLCIS-TRANS ISOMERASEFKBP1A (Escherichiacoli;Homo sapiens) |
PF00254(FKBP_C) | 8 | TYR A 26ASP A 37PHE A 46GLU A 54VAL A 55ILE A 56TYR A 82PHE A 146 | None | 0.51A | 5hkgA-5i7pA:20.0 | 5hkgA-5i7pA:52.60 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5i7q | PEPTIDYL-PROLYLCIS-TRANS ISOMERASEFKBP1A,FKBP-TYPE 16KDA PEPTIDYL-PROLYLCIS-TRANSISOMERASE,PEPTIDYL-PROLYL CIS-TRANSISOMERASE FKBP1A (Escherichiacoli;Homo sapiens) |
PF00254(FKBP_C) | 8 | ASP A 37PHE A 46GLU A 54VAL A 55ILE A 56TYR A 82HIS A 138PHE A 147 | None | 1.03A | 5hkgA-5i7qA:20.1 | 5hkgA-5i7qA:56.13 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5i7q | PEPTIDYL-PROLYLCIS-TRANS ISOMERASEFKBP1A,FKBP-TYPE 16KDA PEPTIDYL-PROLYLCIS-TRANSISOMERASE,PEPTIDYL-PROLYL CIS-TRANSISOMERASE FKBP1A (Escherichiacoli;Homo sapiens) |
PF00254(FKBP_C) | 8 | TYR A 26ASP A 37PHE A 46GLU A 54VAL A 55ILE A 56TYR A 82PHE A 147 | None | 0.69A | 5hkgA-5i7qA:20.1 | 5hkgA-5i7qA:56.13 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5i98 | FK506-BINDINGPROTEIN 1 (Candidaalbicans) |
PF00254(FKBP_C) | 7 | TYR A 30ASP A 41PHE A 50VAL A 59ILE A 60TYR A 97ILE A 102 | None | 1.42A | 5hkgA-5i98A:18.7 | 5hkgA-5i98A:45.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5i98 | FK506-BINDINGPROTEIN 1 (Candidaalbicans) |
PF00254(FKBP_C) | 8 | TYR A 30ASP A 41PHE A 50VAL A 59ILE A 60TYR A 97ILE A 106PHE A 114 | None | 0.56A | 5hkgA-5i98A:18.7 | 5hkgA-5i98A:45.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5j6e | FK506-BINDINGPROTEIN 1A (Aspergillusfumigatus) |
PF00254(FKBP_C) | 8 | TYR A 27ASP A 38PHE A 47VAL A 56ILE A 57TYR A 83ILE A 92PHE A 100 | None | 0.62A | 5hkgA-5j6eA:20.4 | 5hkgA-5j6eA:58.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jcv | LMO2181 PROTEIN (Listeriamonocytogenes) |
PF04203(Sortase) | 5 | ASP A 125VAL A 75ILE A 89TYR A 161ILE A 221 | None | 1.10A | 5hkgA-5jcvA:undetectable | 5hkgA-5jcvA:19.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k9x | TRYPTOPHAN SYNTHASEALPHA CHAIN (Legionellapneumophila) |
PF00290(Trp_syntA) | 5 | VAL A 232ILE A 231TYR A 175VAL A 129ILE A 127 | None | 1.15A | 5hkgA-5k9xA:undetectable | 5hkgA-5k9xA:16.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mp2 | TYPE II SECRETIONSYSTEM PROTEIN D (Pseudomonasaeruginosa) |
no annotation | 5 | VAL A 115ILE A 124PHE A 77VAL A 87ILE A 62 | None | 1.11A | 5hkgA-5mp2A:undetectable | 5hkgA-5mp2A:25.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5msz | THERMOBIA DOMESTICADOMESTICA AA15 (Thermobiadomestica) |
no annotation | 5 | ASP A 84VAL A 72ILE A 190TYR A 75ILE A 81 | None | 1.13A | 5hkgA-5mszA:undetectable | 5hkgA-5mszA:21.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v8t | UBIQUITIN-LIKEPROTEINSMT3,PEPTIDYL-PROLYLCIS-TRANS ISOMERASE (Burkholderiapseudomallei;Saccharomycescerevisiae) |
no annotation | 9 | TYR A 33ASP A 44PHE A 53VAL A 62ILE A 63TYR A 89VAL A 97ILE A 98PHE A 106 | 8ZV A 201 (-3.8A)8ZV A 201 (-3.9A)8ZV A 201 (-3.9A)8ZV A 201 (-3.6A)8ZV A 201 (-4.0A)8ZV A 201 (-4.6A)None8ZV A 201 ( 4.8A)8ZV A 201 (-4.6A) | 0.82A | 5hkgA-5v8tA:18.6 | 5hkgA-5v8tA:21.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xb0 | PEPTIDYL-PROLYLCIS-TRANS ISOMERASE (Pseudomonassyringae groupgenomosp. 3) |
PF00254(FKBP_C) | 7 | TYR A 147ASP A 158PHE A 166ILE A 172TYR A 198ILE A 207PHE A 215 | TLA A 301 ( 4.4A)TLA A 301 (-3.7A)TLA A 301 ( 4.6A)TLA A 301 (-3.4A)NoneNoneNone | 1.12A | 5hkgA-5xb0A:15.0 | 5hkgA-5xb0A:29.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xb0 | PEPTIDYL-PROLYLCIS-TRANS ISOMERASE (Pseudomonassyringae groupgenomosp. 3) |
PF00254(FKBP_C) | 7 | TYR A 147ASP A 158VAL A 171ILE A 172TYR A 198ILE A 207PHE A 215 | TLA A 301 ( 4.4A)TLA A 301 (-3.7A)TLA A 301 (-3.4A)TLA A 301 (-3.4A)NoneNoneNone | 0.70A | 5hkgA-5xb0A:15.0 | 5hkgA-5xb0A:29.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yax | SCFV1 ANTIBODY (Homo sapiens) |
no annotation | 5 | TYR A1042VAL A1116ILE A1117PHE A1118ILE A1030 | None | 1.18A | 5hkgA-5yaxA:undetectable | 5hkgA-5yaxA:15.04 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6b4p | PEPTIDYLPROLYLISOMERASE (Naegleriafowleri) |
no annotation | 9 | TYR A 38ASP A 49PHE A 58GLU A 66VAL A 67ILE A 68TYR A 94ILE A 103PHE A 111 | None | 0.73A | 5hkgA-6b4pA:19.2 | 5hkgA-6b4pA:37.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c8s | LOGANIC ACIDO-METHYLTRANSFERASE (Catharanthusroseus) |
no annotation | 5 | ASP A 75GLU A 93VAL A 92PHE A 133ILE A 152 | SAH A 401 ( 4.6A)NoneNoneNoneNone | 1.00A | 5hkgA-6c8sA:undetectable | 5hkgA-6c8sA:21.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c8s | LOGANIC ACIDO-METHYLTRANSFERASE (Catharanthusroseus) |
no annotation | 5 | GLU A 93VAL A 92ILE A 73PHE A 133HIS A 156 | None | 1.18A | 5hkgA-6c8sA:undetectable | 5hkgA-6c8sA:21.82 |