SIMILAR PATTERNS OF AMINO ACIDS FOR 5HIE_D_P06D801_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dpp DIPEPTIDE BINDING
PROTEIN

(Escherichia
coli) 		PF00496
(SBP_bac_5) 		4 GLY A 117
PHE A 137
ASN A 414
ASP A 149
 None
 0.91A 5hieD-1dppA:
0.0		 5hieD-1dppA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ecg GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Escherichia
coli) 		PF00156
(Pribosyltran)
PF13522
(GATase_6) 		4 ILE A 174
GLY A  95
PHE A 153
PHE A 239
 None
 0.84A 5hieD-1ecgA:
0.0		 5hieD-1ecgA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f39 REPRESSOR PROTEIN CI

(Escherichia
virus Lambda) 		PF00717
(Peptidase_S24) 		4 ILE A 181
GLY A 223
PHE A 202
ASP A 178
 None
 0.89A 5hieD-1f39A:
undetectable		 5hieD-1f39A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g3r CELL DIVISION
INHIBITOR

(Pyrococcus
furiosus) 		PF13614
(AAA_31) 		4 GLY A  15
PHE A 114
ASN A  45
ASP A 118
 ACP  A 238 (-3.0A)
None
None
MG  A 239 ( 4.1A)
 0.90A 5hieD-1g3rA:
0.0		 5hieD-1g3rA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gng GLYCOGEN SYNTHASE
KINASE-3 BETA

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A  62
GLY A  63
ASP A 200
PHE A 201
 None
 0.75A 5hieD-1gngA:
21.0		 5hieD-1gngA:
29.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzj EGI

(Thermoascus
aurantiacus) 		PF00150
(Cellulase) 		4 ILE A 237
GLY A 269
PHE A 284
ASN A  46
 None
 0.81A 5hieD-1gzjA:
undetectable		 5hieD-1gzjA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hl2 N-ACETYLNEURAMINATE
LYASE SUBUNIT

(Escherichia
coli) 		PF00701
(DHDPS) 		4 ILE A 206
GLY A 205
PHE A  33
ASP A  40
 3PY  A 802 ( 4.9A)
None
None
None
 0.75A 5hieD-1hl2A:
undetectable		 5hieD-1hl2A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ion PROBABLE CELL
DIVISION INHIBITOR
MIND

(Pyrococcus
horikoshii) 		PF13614
(AAA_31) 		4 GLY A  15
PHE A 114
ASN A  45
ASP A 118
 ADP  A 301 (-3.0A)
None
None
MG  A 302 ( 4.0A)
 0.90A 5hieD-1ionA:
undetectable		 5hieD-1ionA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jc2 TROPONIN C, SKELETAL
MUSCLE

(Gallus gallus) 		PF13499
(EF-hand_7) 		5 ILE A 134
GLY A 119
PHE A 102
ASP A 114
PHE A 112
 None
None
None
CA  A   2 ( 4.6A)
None
 1.37A 5hieD-1jc2A:
undetectable		 5hieD-1jc2A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k3s SIGE

(Salmonella
enterica) 		PF07824
(Chaperone_III) 		4 ILE A  70
GLY A  71
PHE A  33
PHE A  98
 None
 0.89A 5hieD-1k3sA:
undetectable		 5hieD-1k3sA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m7j D-AMINOACYLASE

(Alcaligenes
faecalis) 		PF07969
(Amidohydro_3) 		4 ILE A 184
GLY A 185
PHE A 123
ASN A  95
 None
 0.82A 5hieD-1m7jA:
undetectable		 5hieD-1m7jA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1omx ALPHA-1,4-N-ACETYLHE
XOSAMINYLTRANSFERASE
EXTL2

(Mus musculus) 		PF09258
(Glyco_transf_64) 		4 ILE A 190
GLY A 189
PHE A 290
ASN A 302
 None
 0.79A 5hieD-1omxA:
undetectable		 5hieD-1omxA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pp1 P40 NUCLEOPROTEIN

(Borna disease
virus) 		PF06407
(BDV_P40) 		4 ILE X 145
GLY X 146
ASN X 189
PHE X  78
 None
 0.94A 5hieD-1pp1X:
undetectable		 5hieD-1pp1X:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1px8 BETA-XYLOSIDASE

(Thermoanaerobacterium
saccharolyticum) 		PF01229
(Glyco_hydro_39) 		4 ILE A 142
GLY A 146
PHE A  97
PHE A  89
 None
 0.94A 5hieD-1px8A:
undetectable		 5hieD-1px8A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sgj CITRATE LYASE, BETA
SUBUNIT

(Deinococcus
radiodurans) 		PF03328
(HpcH_HpaI) 		4 ILE A  35
GLY A  16
ASP A  86
PHE A  83
 None
 0.86A 5hieD-1sgjA:
undetectable		 5hieD-1sgjA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sus CAFFEOYL-COA
O-METHYLTRANSFERASE

(Medicago sativa) 		PF01596
(Methyltransf_3) 		4 ILE A  86
GLY A  87
PHE A  70
ASP A 189
 None
SAH  A 301 (-3.4A)
None
CA  A 305 (-3.2A)
 0.93A 5hieD-1susA:
undetectable		 5hieD-1susA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0m PUTATIVE POLYKETIDE
SYNTHASE

(Streptomyces
coelicolor) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 ILE A 192
GLY A 191
PHE A 231
PHE A 109
 None
 0.90A 5hieD-1u0mA:
undetectable		 5hieD-1u0mA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6m ACETYLTRANSFERASE,
GNAT FAMILY

(Enterococcus
faecalis) 		PF00583
(Acetyltransf_1) 		4 ILE A 129
GLY A 128
PHE A 169
ASP A 135
 None
SO4  A1003 ( 4.3A)
None
None
 0.46A 5hieD-1u6mA:
undetectable		 5hieD-1u6mA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uc4 DIOL DEHYDRASE ALPHA
SUBUNIT
DIOL DEHYDRASE BETA
SUBUNIT

(Klebsiella
oxytoca) 		PF02286
(Dehydratase_LU)
PF02288
(Dehydratase_MU) 		4 ILE B 205
GLY A 269
PHE B  71
PHE B 108
 None
 0.88A 5hieD-1uc4B:
undetectable		 5hieD-1uc4B:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ur1 ENDOXYLANASE

(Cellvibrio
mixtus) 		PF00331
(Glyco_hydro_10) 		4 ILE A 236
GLY A 235
ASN A 347
ASP A 264
 None
 0.94A 5hieD-1ur1A:
undetectable		 5hieD-1ur1A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8i PUTATIVE VAPC
RIBONUCLEASE AF_1683

(Archaeoglobus
fulgidus) 		PF01850
(PIN) 		4 ILE A 129
GLY A 130
PHE A  99
ASP A   6
 None
 0.89A 5hieD-1w8iA:
undetectable		 5hieD-1w8iA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xeu INTERNALIN C

(Listeria
monocytogenes) 		PF08191
(LRR_adjacent)
PF12354
(Internalin_N)
PF12799
(LRR_4) 		4 ILE A 137
GLY A 136
CYH A 141
ASP A 117
 None
 0.89A 5hieD-1xeuA:
undetectable		 5hieD-1xeuA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ypf GMP REDUCTASE

(Bacillus
anthracis) 		PF00478
(IMPDH) 		4 ILE A 119
GLY A  93
ASN A  44
PHE A 142
 None
 0.95A 5hieD-1ypfA:
undetectable		 5hieD-1ypfA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yxm PEROXISOMAL TRANS
2-ENOYL COA
REDUCTASE

(Homo sapiens) 		PF13561
(adh_short_C2) 		5 ILE A  81
GLY A 108
PHE A  98
ASN A 156
PHE A 103
 None
 1.41A 5hieD-1yxmA:
undetectable		 5hieD-1yxmA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7e PROTEIN ARNA

(Escherichia
coli) 		PF00551
(Formyl_trans_N)
PF01370
(Epimerase)
PF02911
(Formyl_trans_C) 		4 GLY A 555
PHE A 488
ASP A 559
PHE A 485
 None
 0.91A 5hieD-1z7eA:
undetectable		 5hieD-1z7eA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bll PROTEIN YFBG

(Escherichia
coli) 		PF01370
(Epimerase) 		4 GLY A 555
PHE A 488
ASP A 559
PHE A 485
 None
 0.92A 5hieD-2bllA:
undetectable		 5hieD-2bllA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)

(Arabidopsis
thaliana) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc) 		4 ILE A 625
GLY A 624
CYH A 664
ASN A 615
 None
 0.83A 5hieD-2fgeA:
undetectable		 5hieD-2fgeA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fuv PHOSPHOGLUCOMUTASE

(Salmonella
enterica) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 ILE A 412
GLY A 411
PHE A 266
ASP A 306
 None
None
None
MG  A 901 (-2.1A)
 0.89A 5hieD-2fuvA:
undetectable		 5hieD-2fuvA:
18.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		5 ILE A  34
GLY A  35
CYH A 108
ASP A 169
PHE A 170
 STU  A 400 (-4.2A)
STU  A 400 (-3.3A)
STU  A 400 (-4.0A)
STU  A 400 (-3.6A)
None
 1.08A 5hieD-2gcdA:
24.8		 5hieD-2gcdA:
30.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Staphylococcus
aureus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 ILE A 349
GLY A 348
PHE A 400
ASN A 302
 None
 0.83A 5hieD-2gqdA:
undetectable		 5hieD-2gqdA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnk SAM-DEPENDENT
O-METHYLTRANSFERASE

(Leptospira
interrogans) 		PF01596
(Methyltransf_3) 		4 ILE A  67
GLY A  68
PHE A  51
ASP A 180
 None
SAH  A2001 (-3.3A)
None
None
 0.89A 5hieD-2hnkA:
undetectable		 5hieD-2hnkA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ime 2-HYDROXYCHROMENE-2-
CARBOXYLATE
ISOMERASE

(Pseudomonas
putida) 		PF01323
(DSBA) 		5 ILE A 118
GLY A 117
PHE A   7
PHE A  93
ASN A  83
 None
 1.32A 5hieD-2imeA:
undetectable		 5hieD-2imeA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT

(Thermus
thermophilus) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		4 ILE A 664
GLY A 665
PHE A 697
ASP A 419
 None
 0.93A 5hieD-2ipcA:
undetectable		 5hieD-2ipcA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		4 ILE A 428
GLY A 429
CYH A 502
PHE A 565
 4ST  A1687 (-4.2A)
4ST  A1687 (-3.1A)
4ST  A1687 (-4.1A)
None
 0.94A 5hieD-2j0jA:
27.0		 5hieD-2j0jA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l02 UNCHARACTERIZED
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF10771
(DUF2582) 		4 ILE A  63
GLY A  22
PHE A  73
PHE A  71
 None
 0.94A 5hieD-2l02A:
undetectable		 5hieD-2l02A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odt INOSITOL-TETRAKISPHO
SPHATE 1-KINASE

(Homo sapiens) 		PF05770
(Ins134_P3_kin) 		4 ILE X 280
GLY X 279
PHE X 230
PHE X 190
 None
 0.85A 5hieD-2odtX:
undetectable		 5hieD-2odtX:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oe1 THIOREDOXIN-3

(Saccharomyces
cerevisiae) 		PF00085
(Thioredoxin) 		4 ILE A  90
GLY A  91
CYH A  69
ASP A  26
 None
None
SO4  A1002 ( 4.8A)
None
 0.94A 5hieD-2oe1A:
undetectable		 5hieD-2oe1A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pg6 CYTOCHROME P450 2A6

(Homo sapiens) 		PF00067
(p450) 		4 GLY A 336
PHE A 452
ASP A 345
PHE A 343
 None
 0.86A 5hieD-2pg6A:
undetectable		 5hieD-2pg6A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pgw MUCONATE
CYCLOISOMERASE

(Sinorhizobium
meliloti) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ILE A 275
GLY A 276
CYH A 269
PHE A 301
 None
 0.86A 5hieD-2pgwA:
undetectable		 5hieD-2pgwA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyx TRYPTOPHAN
HALOGENASE

(Shewanella
frigidimarina) 		PF04820
(Trp_halogenase) 		4 ILE A  72
GLY A  73
PHE A 163
PHE A 522
 None
 0.87A 5hieD-2pyxA:
undetectable		 5hieD-2pyxA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qr7 RIBOSOMAL PROTEIN S6
KINASE ALPHA-3

(Mus musculus) 		PF00069
(Pkinase) 		4 ILE A 428
GLY A 429
ASP A 561
PHE A 562
 None
 0.83A 5hieD-2qr7A:
19.8		 5hieD-2qr7A:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyz UNCHARACTERIZED
PROTEIN

(Clostridium
tetani) 		PF09643
(YopX) 		4 ILE A  71
GLY A 120
CYH A  95
ASP A  60
 None
 0.88A 5hieD-2qyzA:
undetectable		 5hieD-2qyzA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzx CANDIDAPEPSIN-5

(Candida
albicans) 		PF00026
(Asp) 		4 ILE A 174
GLY A 173
PHE A 128
ASN A 342
 None
 0.86A 5hieD-2qzxA:
undetectable		 5hieD-2qzxA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w49 TROPONIN C, SKELETAL
MUSCLE

(Gallus gallus) 		PF13499
(EF-hand_7)
PF13833
(EF-hand_8) 		4 GLY 0 118
PHE 0 150
ASP 0 113
PHE 0 111
 None
None
CA  01001 ( 4.3A)
None
 0.86A 5hieD-2w490:
undetectable		 5hieD-2w490:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xu2 UPF0271 PROTEIN
PA4511

(Pseudomonas
aeruginosa) 		PF03746
(LamB_YcsF) 		4 ILE A  65
GLY A  66
PHE A  19
ASP A  14
 None
None
None
CIT  A1249 (-2.9A)
 0.82A 5hieD-2xu2A:
undetectable		 5hieD-2xu2A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yky BETA-TRANSAMINASE

(Mesorhizobium
sp. LUK) 		PF00202
(Aminotran_3) 		4 ILE A 282
GLY A 283
PHE A 301
CYH A 130
 None
 0.94A 5hieD-2ykyA:
undetectable		 5hieD-2ykyA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z9s PEROXIREDOXIN-1

(Rattus
norvegicus) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		4 ILE A   8
GLY A   9
PHE A 165
ASP A 134
 None
 0.82A 5hieD-2z9sA:
undetectable		 5hieD-2z9sA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z9s PEROXIREDOXIN-1

(Rattus
norvegicus) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		4 ILE A 125
GLY A 124
ASP A 107
PHE A  15
 None
 0.88A 5hieD-2z9sA:
undetectable		 5hieD-2z9sA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zyj ALPHA-AMINODIPATE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00155
(Aminotran_1_2) 		4 ILE A 129
GLY A 127
ASN A 174
ASP A 202
 None
None
PGU  A 500 (-3.5A)
PGU  A 500 (-2.8A)
 0.93A 5hieD-2zyjA:
undetectable		 5hieD-2zyjA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2f DNA POLYMERASE

(Pyrococcus
furiosus) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 ILE A 228
GLY A 227
PHE A 152
PHE A 214
 None
 0.80A 5hieD-3a2fA:
undetectable		 5hieD-3a2fA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ab4 ASPARTOKINASE

(Corynebacterium
glutamicum) 		PF00696
(AA_kinase)
PF01842
(ACT)
PF13840
(ACT_7) 		4 ILE A 383
GLY A 351
PHE B  34
PHE B  63
 None
 0.86A 5hieD-3ab4A:
undetectable		 5hieD-3ab4A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ab4 ASPARTOKINASE

(Corynebacterium
glutamicum) 		PF00696
(AA_kinase)
PF01842
(ACT)
PF13840
(ACT_7) 		4 ILE B 134
GLY B 102
PHE A 283
PHE A 312
 None
 0.82A 5hieD-3ab4B:
undetectable		 5hieD-3ab4B:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aeq LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT B

(Rhodobacter
capsulatus) 		PF00148
(Oxidored_nitro) 		4 ILE B 237
GLY B 238
PHE B 207
ASP B 244
 None
 0.93A 5hieD-3aeqB:
undetectable		 5hieD-3aeqB:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cbg O-METHYLTRANSFERASE

(Synechocystis
sp. PCC 6803) 		PF01596
(Methyltransf_3) 		4 ILE A  67
GLY A  68
PHE A  51
ASP A 169
 None
SAH  A 301 (-3.7A)
None
MG  A 401 (-3.4A)
 0.80A 5hieD-3cbgA:
undetectable		 5hieD-3cbgA:
26.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dqg HEAT SHOCK 70 KDA
PROTEIN F

(Caenorhabditis
elegans) 		PF00012
(HSP70) 		4 ILE A 432
GLY A 431
PHE A 482
ASN A 476
 None
 0.94A 5hieD-3dqgA:
undetectable		 5hieD-3dqgA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dul O-METHYLTRANSFERASE,
PUTATIVE

(Bacillus cereus) 		PF01596
(Methyltransf_3) 		4 ILE A  65
GLY A  66
PHE A  49
ASP A 166
 None
 0.75A 5hieD-3dulA:
undetectable		 5hieD-3dulA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dxq CHOLINE/ETHANOLAMINE
KINASE FAMILY
PROTEIN

(Mesorhizobium
loti) 		PF01633
(Choline_kinase) 		4 ILE A 244
GLY A 240
CYH A 249
PHE A 113
 None
 0.91A 5hieD-3dxqA:
6.7		 5hieD-3dxqA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e4e CYTOCHROME P450 2E1

(Homo sapiens) 		PF00067
(p450) 		4 ILE A 289
GLY A 288
PHE A 203
ASP A 295
 None
 0.93A 5hieD-3e4eA:
undetectable		 5hieD-3e4eA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eaf ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN

(Aeropyrum
pernix) 		PF13458
(Peripla_BP_6) 		4 ILE A 121
GLY A 123
ASN A 158
PHE A 370
 None
 0.94A 5hieD-3eafA:
undetectable		 5hieD-3eafA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN

(Geobacillus
kaustophilus) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		4 GLY A1183
PHE A1231
CYH A1264
ASP A1215
 None
 0.77A 5hieD-3f2bA:
undetectable		 5hieD-3f2bA:
13.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f3z CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		4 GLY A  37
CYH A 105
ASP A 169
PHE A 170
 None
DRK  A   1 (-4.1A)
None
None
 0.86A 5hieD-3f3zA:
23.3		 5hieD-3f3zA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdb PUTATIVE
PLP-DEPENDENT
BETA-CYSTATHIONASE

(Corynebacterium
diphtheriae) 		PF00155
(Aminotran_1_2) 		4 ILE A 320
GLY A 322
ASP A 338
PHE A 342
 EDO  A 388 (-4.7A)
EDO  A 388 (-4.2A)
EDO  A 390 ( 4.5A)
None
 0.86A 5hieD-3fdbA:
undetectable		 5hieD-3fdbA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fii BOTULINUM NEUROTOXIN
TYPE F
FRAGMENT OF
VESICLE-ASSOCIATED
MEMBRANE PROTEIN 2

(Clostridium
botulinum;
Homo sapiens) 		PF00957
(Synaptobrevin)
PF01742
(Peptidase_M27) 		4 ILE A  52
GLY A  53
ASN B  49
ASP B  51
 None
 0.94A 5hieD-3fiiA:
undetectable		 5hieD-3fiiA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gkq TERMINAL OXYGENASE
COMPONENT OF
CARBAZOLE
1,9A-DIOXYGENASE

(Sphingomonas
sp. KA1) 		PF00355
(Rieske)
PF11723
(Aromatic_hydrox) 		4 ILE A 194
GLY A 329
PHE A 240
PHE A 188
 None
 0.95A 5hieD-3gkqA:
undetectable		 5hieD-3gkqA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h11 CASP8 AND FADD-LIKE
APOPTOSIS REGULATOR

(Homo sapiens) 		PF00656
(Peptidase_C14) 		4 ILE A 260
GLY A 261
PHE A 355
PHE A 271
 None
 0.83A 5hieD-3h11A:
undetectable		 5hieD-3h11A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hko CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 2
CALMODULIN-LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		4 GLY A  19
CYH A  92
ASP A 195
PHE A 196
 ANP  A 329 (-3.3A)
ANP  A 329 (-4.1A)
MG  A 330 ( 2.9A)
None
 0.78A 5hieD-3hkoA:
21.3		 5hieD-3hkoA:
26.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hn6 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE

(Borreliella
burgdorferi) 		PF01182
(Glucosamine_iso) 		4 ILE A  46
GLY A  47
PHE A 134
ASN A 204
 None
 0.72A 5hieD-3hn6A:
undetectable		 5hieD-3hn6A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihl CTP SYNTHASE 2

(Homo sapiens) 		PF06418
(CTP_synth_N) 		4 ILE A  14
GLY A   9
PHE A 163
PHE A 159
 ADP  A 300 (-4.9A)
None
None
None
 0.86A 5hieD-3ihlA:
undetectable		 5hieD-3ihlA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3is5 CALCIUM-DEPENDENT
PROTEIN KINASE

(Toxoplasma
gondii) 		PF00069
(Pkinase) 		4 GLY A 142
CYH A 213
ASP A 281
PHE A 282
 ANP  A   1 (-3.5A)
ANP  A   1 (-4.3A)
MG  A 399 ( 3.0A)
GOL  A 398 (-4.5A)
 0.87A 5hieD-3is5A:
19.4		 5hieD-3is5A:
29.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j2i PROLIFERATION-ASSOCI
ATED PROTEIN 2G4

(Homo sapiens) 		PF00557
(Peptidase_M24) 		4 ILE A 182
GLY A 235
ASN A 171
PHE A 177
 None
 0.95A 5hieD-3j2iA:
undetectable		 5hieD-3j2iA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kf3 INVERTASE

(Schwanniomyces
occidentalis) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		5 ILE A 413
GLY A 430
PHE A 455
PHE A 502
ASP A 441
 None
 1.44A 5hieD-3kf3A:
undetectable		 5hieD-3kf3A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mi9 CELL DIVISION
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A  25
CYH A 106
ASP A 167
PHE A 168
 None
 0.81A 5hieD-3mi9A:
22.5		 5hieD-3mi9A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus scrofa) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		4 ILE A 850
GLY A 851
PHE A 985
PHE A 860
 None
 0.95A 5hieD-3n23A:
undetectable		 5hieD-3n23A:
15.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ILE A 355
GLY A 356
CYH A 424
ASP A 486
PHE A 487
 SM5  A   1 (-4.3A)
SM5  A   1 ( 4.9A)
SM5  A   1 ( 4.4A)
SM5  A   1 (-3.5A)
None
 1.08A 5hieD-3omvA:
34.6		 5hieD-3omvA:
77.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ILE A 355
GLY A 356
PHE A 408
ASN A 472
 SM5  A   1 (-4.3A)
SM5  A   1 ( 4.9A)
None
SM5  A   1 (-3.9A)
 0.88A 5hieD-3omvA:
34.6		 5hieD-3omvA:
77.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ILE A 355
GLY A 356
PHE A 408
CYH A 424
 SM5  A   1 (-4.3A)
SM5  A   1 ( 4.9A)
None
SM5  A   1 ( 4.4A)
 0.50A 5hieD-3omvA:
34.6		 5hieD-3omvA:
77.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opy 6-PHOSPHOFRUCTO-1-KI
NASE BETA-SUBUNIT

(Komagataella
pastoris) 		PF00365
(PFK) 		4 ILE B 844
GLY B 843
CYH B 353
ASP B 849
 None
 0.88A 5hieD-3opyB:
undetectable		 5hieD-3opyB:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdx TYROSINE
AMINOTRANSFERASE

(Mus musculus) 		PF00155
(Aminotran_1_2) 		4 ILE A 305
GLY A 302
CYH A 151
ASP A 137
 None
 0.88A 5hieD-3pdxA:
undetectable		 5hieD-3pdxA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppc 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Candida
albicans) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		4 ILE A 490
GLY A 491
PHE A 733
PHE A 763
 None
 0.83A 5hieD-3ppcA:
undetectable		 5hieD-3ppcA:
18.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		4 ILE A 557
GLY A 558
PHE A 611
PHE A 695
 STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
None
None
 0.90A 5hieD-3ppzA:
28.0		 5hieD-3ppzA:
38.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q46 TT-IPPASE

(Thermococcus
thioreducens) 		PF00719
(Pyrophosphatase) 		4 ILE A  93
GLY A 154
PHE A 116
ASP A 121
 None
 0.89A 5hieD-3q46A:
undetectable		 5hieD-3q46A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q75 FARNESYLTRANSFERASE
BETA SUBUNIT

(Cryptococcus
neoformans) 		PF00432
(Prenyltrans) 		4 ILE B 486
GLY B 489
PHE B  41
PHE B 383
 None
3CX  B 523 (-3.3A)
None
None
 0.87A 5hieD-3q75B:
undetectable		 5hieD-3q75B:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qw3 OROTIDINE-5-PHOSPHAT
E
DECARBOXYLASE/OROTAT
E
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE
(OMPDCASE-OPRTASE,
PUTATIVE)

(Leishmania
infantum) 		PF00215
(OMPdecase) 		4 ILE A  77
GLY A  76
PHE A 100
CYH A  17
 None
 0.95A 5hieD-3qw3A:
undetectable		 5hieD-3qw3A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rcy MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN

(Roseovarius sp.
TM1035) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ILE A  34
GLY A  33
CYH A 101
ASP A   5
 None
 0.92A 5hieD-3rcyA:
undetectable		 5hieD-3rcyA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3snx PUTATIVE SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 GLY A 416
PHE A 471
PHE A 462
ASP A  82
 EDO  A 499 (-4.2A)
None
None
None
 0.93A 5hieD-3snxA:
undetectable		 5hieD-3snxA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ti8 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 ILE A 106
GLY A 105
PHE A 446
PHE A 374
 None
 0.92A 5hieD-3ti8A:
undetectable		 5hieD-3ti8A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9s METHYLCROTONYL-COA
CARBOXYLASE,
ALPHA-SUBUNIT

(Pseudomonas
aeruginosa) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 ILE A 113
GLY A 110
PHE A 429
ASN A 135
 None
 0.86A 5hieD-3u9sA:
undetectable		 5hieD-3u9sA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vpz GLUCOKINASE

(Pseudoalteromonas
sp. AS-131) 		PF02685
(Glucokinase) 		4 ILE A  16
GLY A  17
CYH A  72
ASP A 112
 None
 0.74A 5hieD-3vpzA:
undetectable		 5hieD-3vpzA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0h ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(Arabidopsis
thaliana) 		PF00202
(Aminotran_3)
PF13500
(AAA_26) 		4 ILE A 772
GLY A 771
CYH A 366
ASN A 347
 None
 0.95A 5hieD-4a0hA:
undetectable		 5hieD-4a0hA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agu CYCLIN-DEPENDENT
KINASE-LIKE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A  10
GLY A  11
CYH A  83
PHE A 145
 D15  A 500 (-4.2A)
D15  A 500 (-3.8A)
D15  A 500 (-4.3A)
None
 0.79A 5hieD-4aguA:
23.9		 5hieD-4aguA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aoa BETA-PHENYLALANINE
AMINOTRANSFERASE

(Variovorax
paradoxus) 		PF00202
(Aminotran_3) 		4 ILE A 269
GLY A 270
PHE A 288
CYH A 117
 None
 0.87A 5hieD-4aoaA:
undetectable		 5hieD-4aoaA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		4 ILE A  83
GLY A  84
ASP A 219
PHE A 220
 None
 0.93A 5hieD-4aw2A:
20.4		 5hieD-4aw2A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8t KH-TYPE SPLICING
REGULATORY PROTEIN

(Homo sapiens) 		PF00013
(KH_1) 		4 ILE A   9
GLY A  10
PHE A  46
ASP A  14
 None
None
G  B   3 ( 3.8A)
None
 0.89A 5hieD-4b8tA:
undetectable		 5hieD-4b8tA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4btm TAU-TUBULIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A  64
GLY A  65
PHE A 117
ASN A 137
PHE A 201
 F8E  A1340 (-4.8A)
F8E  A1340 ( 4.3A)
None
F8E  A1340 ( 4.5A)
None
 0.96A 5hieD-4btmA:
19.8		 5hieD-4btmA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c22 L-FUCOSE ISOMERASE

(Streptococcus
pneumoniae) 		PF02952
(Fucose_iso_C)
PF07881
(Fucose_iso_N1)
PF07882
(Fucose_iso_N2) 		4 ILE A 189
GLY A 186
PHE A 332
PHE A 297
 None
 0.85A 5hieD-4c22A:
undetectable		 5hieD-4c22A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4db3 N-ACETYL-D-GLUCOSAMI
NE KINASE

(Vibrio
vulnificus) 		PF00480
(ROK) 		4 GLY A 136
PHE A 194
CYH A 236
ASP A 186
 None
 0.91A 5hieD-4db3A:
undetectable		 5hieD-4db3A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e7w GLYCOGEN SYNTHASE
KINASE 3

(Ustilago maydis) 		PF00069
(Pkinase) 		4 ILE A  44
GLY A  45
ASP A 181
PHE A 182
 None
 0.84A 5hieD-4e7wA:
20.4		 5hieD-4e7wA:
26.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4flx DNA POLYMERASE 1

(Pyrococcus
abyssi) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 ILE A 228
GLY A 227
PHE A 152
PHE A 214
 ILE  A 228 ( 0.7A)
GLY  A 227 ( 0.0A)
PHE  A 152 ( 1.3A)
PHE  A 214 ( 1.3A)
 0.94A 5hieD-4flxA:
undetectable		 5hieD-4flxA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g2r ACCD6,
CARBOXYLTRANSFERASE
BETA-SUBUNIT OF
ACYL-COA CARBOXYLASE

(Mycobacterium
tuberculosis) 		PF01039
(Carboxyl_trans) 		4 GLY A 210
CYH A 310
ASP A 259
PHE A 258
 None
 0.90A 5hieD-4g2rA:
undetectable		 5hieD-4g2rA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g6t TYPE III CHAPERONE
PROTEIN SHCA

(Pseudomonas
syringae group
genomosp. 3) 		PF05932
(CesT) 		4 ILE A  54
GLY A  55
CYH A  44
ASN A  31
 None
 0.85A 5hieD-4g6tA:
undetectable		 5hieD-4g6tA:
18.64