SIMILAR PATTERNS OF AMINO ACIDS FOR 5HIE_C_P06C801

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 VAL A 209
ALA A 220
LYS A 222
THR A 266
ASP A 332
 None
 0.60A 5hieC-1k9aA:
27.0		 5hieC-1k9aA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kbz DTDP-GLUCOSE
OXIDOREDUCTASE

(Salmonella
enterica) 		PF04321
(RmlD_sub_bind) 		6 GLY A  10
GLY A   7
VAL A  12
ALA A 193
LEU A  20
THR A 196
 None
 1.49A 5hieC-1kbzA:
undetectable		 5hieC-1kbzA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1py5 TGF-BETA RECEPTOR
TYPE I

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		6 GLY A 212
VAL A 219
ALA A 230
LYS A 232
LEU A 260
ASP A 351
 None
PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 (-3.9A)
PY1  A 700 (-4.2A)
PY1  A 700 (-2.7A)
 0.92A 5hieC-1py5A:
25.6		 5hieC-1py5A:
29.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 GLY A 596
VAL A 603
ALA A 621
LYS A 623
THR A 670
 None
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.2A)
 0.40A 5hieC-1t46A:
23.3		 5hieC-1t46A:
30.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		6 GLY A  35
VAL A  42
ALA A  55
LYS A  57
GLY A 168
ASP A 169
 None
 0.87A 5hieC-1u5qA:
23.9		 5hieC-1u5qA:
31.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  16
GLY A  18
VAL A  23
ALA A  36
LYS A  38
ASP A 148
 HYM  A 400 ( 3.8A)
HYM  A 400 ( 3.7A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
HYM  A 400 (-3.9A)
 0.84A 5hieC-1zltA:
14.6		 5hieC-1zltA:
25.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY X  18
VAL X  25
ALA X  37
LYS X  39
THR X  82
ASP X 148
 STU  X 902 ( 3.7A)
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
STU  X 902 (-4.1A)
STU  X 902 (-3.6A)
 0.76A 5hieC-2dq7X:
26.6		 5hieC-2dq7X:
33.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 GLY A 274
VAL A 281
ALA A 293
LYS A 295
THR A 338
 H8H  A 534 ( 3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
H8H  A 534 (-3.1A)
 0.39A 5hieC-2h8hA:
26.4		 5hieC-2h8hA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 GLY A 274
GLY A 276
VAL A 281
ALA A 293
LYS A 295
THR A 338
 QUE  A   1 ( 4.2A)
None
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.3A)
 0.94A 5hieC-2hckA:
26.8		 5hieC-2hckA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 249
GLY A 383
VAL A 256
ALA A 269
LYS A 271
THR A 315
 None
None
GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.4A)
 0.87A 5hieC-2hz0A:
26.6		 5hieC-2hz0A:
29.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 250
VAL A 256
ALA A 269
LYS A 271
THR A 315
ASP A 381
 None
GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.4A)
GIN  A 600 (-4.9A)
 0.87A 5hieC-2hz0A:
26.6		 5hieC-2hz0A:
29.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 383
VAL A 256
ALA A 269
LYS A 271
THR A 315
ASP A 381
 None
GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.4A)
GIN  A 600 (-4.9A)
 0.76A 5hieC-2hz0A:
26.6		 5hieC-2hz0A:
29.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 589
VAL A 596
ALA A 614
LYS A 616
THR A 663
GLY A 795
 None
 0.71A 5hieC-2ogvA:
18.6		 5hieC-2ogvA:
28.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 798
ALA A 614
LYS A 616
THR A 663
GLY A 795
ASP A 796
 None
 1.07A 5hieC-2ogvA:
18.6		 5hieC-2ogvA:
28.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 798
VAL A 596
ALA A 614
LYS A 616
THR A 663
GLY A 795
 None
 0.72A 5hieC-2ogvA:
18.6		 5hieC-2ogvA:
28.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A 199
VAL A 204
ALA A 215
LYS A 217
LEU A 245
THR A 265
 None
ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
ADE  A 488 ( 4.5A)
ADE  A 488 (-4.3A)
 0.60A 5hieC-2qluA:
26.1		 5hieC-2qluA:
28.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 204
ALA A 215
LYS A 217
LEU A 245
THR A 265
ASP A 339
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
ADE  A 488 ( 4.5A)
ADE  A 488 (-4.3A)
None
 0.58A 5hieC-2qluA:
26.1		 5hieC-2qluA:
28.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 725
VAL A 732
ALA A 749
LYS A 751
THR A 796
ASP A 861
 None
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
GW7  A   1 (-4.0A)
GW7  A   1 (-4.1A)
 1.11A 5hieC-2r4bA:
26.7		 5hieC-2r4bA:
30.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z8c INSULIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A1003
GLY A1005
VAL A1010
ALA A1028
LYS A1030
GLY A1149
 S91  A   1 ( 3.9A)
None
S91  A   1 ( 4.9A)
S91  A   1 (-3.2A)
S91  A   1 ( 4.2A)
None
 0.70A 5hieC-2z8cA:
26.7		 5hieC-2z8cA:
32.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 209
ALA A 220
LYS A 222
THR A 266
ASP A 332
 None
 0.60A 5hieC-3d7uA:
27.8		 5hieC-3d7uA:
29.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 GLY A 695
VAL A 702
ALA A 719
LYS A 721
THR A 766
 ITI  A   1 ( 4.8A)
ITI  A   1 (-4.8A)
ITI  A   1 (-2.9A)
ITI  A   1 (-2.6A)
ITI  A   1 (-3.8A)
 0.58A 5hieC-3lzbA:
26.5		 5hieC-3lzbA:
27.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		6 GLY A 211
GLY A 213
PHE A 233
VAL A 218
ALA A 229
THR A 279
 LDN  A   1 ( 4.7A)
LDN  A   1 ( 4.4A)
None
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
LDN  A   1 (-3.8A)
 1.19A 5hieC-3mdyA:
26.2		 5hieC-3mdyA:
29.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		7 GLY A 211
GLY A 213
VAL A 218
ALA A 229
LEU A 259
THR A 279
ASP A 350
 LDN  A   1 ( 4.7A)
LDN  A   1 ( 4.4A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
LDN  A   1 (-3.8A)
LDN  A   1 (-3.9A)
 0.96A 5hieC-3mdyA:
26.2		 5hieC-3mdyA:
29.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		7 GLY A 211
VAL A 218
ALA A 229
LYS A 231
LEU A 259
THR A 279
ASP A 350
 LDN  A   1 ( 4.7A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
None
LDN  A   1 (-3.8A)
LDN  A   1 (-3.9A)
 1.01A 5hieC-3mdyA:
26.2		 5hieC-3mdyA:
29.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 209
GLY A 214
PHE A 231
VAL A 216
ALA A 227
THR A 277
 None
None
None
LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
 1.42A 5hieC-3my0A:
25.0		 5hieC-3my0A:
28.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 209
PHE A 231
VAL A 216
ALA A 227
LEU A 257
THR A 277
 None
None
LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
None
LDN  A 600 (-4.0A)
 0.80A 5hieC-3my0A:
25.0		 5hieC-3my0A:
28.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 209
VAL A 216
ALA A 227
LYS A 229
LEU A 257
THR A 277
 None
LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
None
LDN  A 600 (-4.0A)
 0.52A 5hieC-3my0A:
25.0		 5hieC-3my0A:
28.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nk7 23S RRNA
METHYLTRANSFERASE

(Streptomyces
actuosus) 		PF00588
(SpoU_methylase)
PF04705
(TSNR_N) 		6 GLY A  47
VAL A  48
ALA A 100
LEU A 161
THR A  32
GLY A 166
 None
 1.40A 5hieC-3nk7A:
undetectable		 5hieC-3nk7A:
22.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 GLY A 356
GLY A 358
VAL A 363
ALA A 373
LEU A 406
THR A 421
TRP A 423
PHE A 475
GLY A 485
 SM5  A   1 ( 4.9A)
None
SM5  A   1 (-4.0A)
SM5  A   1 (-3.6A)
None
SM5  A   1 (-4.4A)
SM5  A   1 (-4.3A)
SM5  A   1 (-3.0A)
None
 0.78A 5hieC-3omvA:
34.8		 5hieC-3omvA:
77.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 358
ALA A 373
LYS A 375
LEU A 406
THR A 421
PHE A 475
GLY A 485
 None
SM5  A   1 (-3.6A)
SM5  A   1 (-3.5A)
None
SM5  A   1 (-4.4A)
SM5  A   1 (-3.0A)
None
 0.89A 5hieC-3omvA:
34.8		 5hieC-3omvA:
77.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 363
ALA A 373
LEU A 406
TRP A 423
PHE A 475
GLY A 485
ASP A 486
 SM5  A   1 (-4.0A)
SM5  A   1 (-3.6A)
None
SM5  A   1 (-4.3A)
SM5  A   1 (-3.0A)
None
SM5  A   1 (-3.5A)
 1.17A 5hieC-3omvA:
34.8		 5hieC-3omvA:
77.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3q4t ACTIVIN RECEPTOR
TYPE-2A

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A 201
VAL A 206
ALA A 217
LEU A 247
THR A 267
 None
TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
None
TAK  A   2 (-3.5A)
 0.57A 5hieC-3q4tA:
25.9		 5hieC-3q4tA:
30.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3q4t ACTIVIN RECEPTOR
TYPE-2A

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A 201
VAL A 206
ALA A 217
LYS A 219
LEU A 247
THR A 267
 None
TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
None
TAK  A   2 (-3.5A)
 1.49A 5hieC-3q4tA:
25.9		 5hieC-3q4tA:
30.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3q4t ACTIVIN RECEPTOR
TYPE-2A

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 206
ALA A 217
LYS A 219
LEU A 247
THR A 267
ASP A 340
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
None
TAK  A   2 (-3.5A)
None
 0.82A 5hieC-3q4tA:
25.9		 5hieC-3q4tA:
30.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		5 VAL A  71
ALA A  84
LYS A  86
THR A 144
ASP A 211
 ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
ANP  A1634 (-4.6A)
MG  A 529 (-2.2A)
 0.58A 5hieC-3q5iA:
20.6		 5hieC-3q5iA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qat MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Bartonella
henselae) 		PF00698
(Acyl_transf_1) 		6 GLY A 300
GLY A 278
PHE A   7
VAL A 299
ALA A 308
LEU A  81
 None
 1.40A 5hieC-3qatA:
undetectable		 5hieC-3qatA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		6 GLY B 596
ALA B 616
LYS B 618
PHE B 942
GLY B 952
ASP B 953
 None
 0.87A 5hieC-3qd2B:
22.0		 5hieC-3qd2B:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		6 GLY B 596
VAL B 603
ALA B 616
PHE B 942
GLY B 952
ASP B 953
 None
 0.83A 5hieC-3qd2B:
22.0		 5hieC-3qd2B:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		6 GLY B 599
ALA B 616
LYS B 618
PHE B 942
GLY B 952
ASP B 953
 None
 0.55A 5hieC-3qd2B:
22.0		 5hieC-3qd2B:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		6 GLY B 599
VAL B 603
ALA B 616
PHE B 942
GLY B 952
ASP B 953
 None
 0.63A 5hieC-3qd2B:
22.0		 5hieC-3qd2B:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfv CDC42BPB PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  83
VAL A  90
ALA A 103
LYS A 105
ASP A 218
 NM7  A 416 (-3.0A)
NM7  A 416 (-3.7A)
NM7  A 416 ( 3.7A)
EDO  A 417 (-3.5A)
EDO  A 417 (-3.7A)
 0.52A 5hieC-3qfvA:
20.8		 5hieC-3qfvA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r3g THROMBIN HEAVY CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		6 GLY B 197
GLY B 211
VAL B 213
ALA B 190
LEU B 160
GLY B 136
 None
 1.39A 5hieC-3r3gB:
undetectable		 5hieC-3r3gB:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3she MAP KINASE-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  51
GLY A  53
VAL A  58
ALA A  71
LYS A  73
ASP A 187
 I85  A 350 (-3.5A)
I85  A 350 (-3.1A)
I85  A 350 (-4.9A)
I85  A 350 (-3.3A)
I85  A 350 (-2.8A)
I85  A 350 (-3.3A)
 0.78A 5hieC-3sheA:
19.9		 5hieC-3sheA:
26.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 424
GLY A 426
VAL A 431
ALA A 443
LYS A 445
THR A 489
 PP2  A   1 ( 4.1A)
PP2  A   1 ( 4.8A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.3A)
 0.69A 5hieC-3sxsA:
26.8		 5hieC-3sxsA:
31.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  60
ALA A  80
LYS A  82
PHE A 183
GLY A 193
ASP A 194
 939  A1331 ( 4.7A)
939  A1331 (-3.5A)
939  A1331 (-2.6A)
939  A1331 (-4.0A)
None
939  A1331 (-3.1A)
 0.82A 5hieC-4a4lA:
20.4		 5hieC-4a4lA:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  60
GLY A  62
ALA A  80
LYS A  82
PHE A 183
GLY A 193
 939  A1331 ( 4.7A)
939  A1331 ( 3.7A)
939  A1331 (-3.5A)
939  A1331 (-2.6A)
939  A1331 (-4.0A)
None
 0.83A 5hieC-4a4lA:
20.4		 5hieC-4a4lA:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		5 GLY A  84
VAL A  91
ALA A 104
LYS A 106
ASP A 219
 None
None
EDO  A1420 (-3.4A)
EDO  A1419 (-3.3A)
None
 0.61A 5hieC-4aw2A:
20.4		 5hieC-4aw2A:
20.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A  98
GLY A 100
VAL A 105
ALA A 121
LYS A 123
THR A 169
 30K  A1365 ( 3.9A)
30K  A1365 ( 4.4A)
30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
30K  A1365 (-3.8A)
 0.85A 5hieC-4aw5A:
26.9		 5hieC-4aw5A:
31.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		6 GLY A 215
PHE A 237
VAL A 222
ALA A 233
LEU A 263
THR A 283
 None
None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
FLC  A1503 ( 4.5A)
TAK  A1507 (-3.6A)
 0.79A 5hieC-4c02A:
5.3		 5hieC-4c02A:
28.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		6 GLY A 215
VAL A 222
ALA A 233
LYS A 235
LEU A 263
THR A 283
 None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
FLC  A1503 ( 4.5A)
TAK  A1507 (-3.6A)
 0.47A 5hieC-4c02A:
5.3		 5hieC-4c02A:
28.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		6 GLY A  23
GLY A  25
VAL A  30
ALA A  43
LYS A  45
ASP A 157
 STU  A1550 (-3.1A)
STU  A1550 (-3.8A)
None
STU  A1550 (-3.1A)
STU  A1550 (-3.6A)
STU  A1550 (-3.6A)
 1.09A 5hieC-4cfhA:
23.8		 5hieC-4cfhA:
23.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 GLY A 617
VAL A 624
ALA A 653
LYS A 655
THR A 701
 None
DI1  A1000 (-4.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.9A)
DI1  A1000 (-3.6A)
 0.58A 5hieC-4ckrA:
24.9		 5hieC-4ckrA:
31.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f0g SERINE/THREONINE-PRO
TEIN KINASE ROCO4

(Dictyostelium
discoideum) 		PF07714
(Pkinase_Tyr) 		6 GLY A1033
GLY A1035
PHE A1037
VAL A1040
ALA A1053
LYS A1055
 None
 1.06A 5hieC-4f0gA:
26.6		 5hieC-4f0gA:
30.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f0g SERINE/THREONINE-PRO
TEIN KINASE ROCO4

(Dictyostelium
discoideum) 		PF07714
(Pkinase_Tyr) 		6 GLY A1033
PHE A1037
VAL A1040
ALA A1053
LYS A1055
PHE A1161
 None
 1.07A 5hieC-4f0gA:
26.6		 5hieC-4f0gA:
30.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 GLY A 856
GLY A 858
VAL A 863
ALA A 880
LYS A 882
GLY A 993
 IZA  A2001 ( 4.9A)
IZA  A2001 ( 3.7A)
None
IZA  A2001 (-3.4A)
IZA  A2001 ( 4.7A)
None
 0.78A 5hieC-4gl9A:
25.6		 5hieC-4gl9A:
29.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 GLY A 856
VAL A 863
ALA A 880
LYS A 882
GLY A 993
ASP A 994
 IZA  A2001 ( 4.9A)
None
IZA  A2001 (-3.4A)
IZA  A2001 ( 4.7A)
None
IZA  A2001 ( 4.5A)
 0.97A 5hieC-4gl9A:
25.6		 5hieC-4gl9A:
29.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzs ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14604
(SH3_9) 		6 GLY A 133
GLY A 135
VAL A 140
ALA A 156
LYS A 158
THR A 205
 None
 0.69A 5hieC-4hzsA:
19.4		 5hieC-4hzsA:
29.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzs ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14604
(SH3_9) 		6 GLY A 133
VAL A 140
ALA A 156
LYS A 158
THR A 205
GLY A 269
 None
 0.73A 5hieC-4hzsA:
19.4		 5hieC-4hzsA:
29.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4id7 ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 133
VAL A 140
ALA A 156
LYS A 158
THR A 205
GLY A 269
 1G0  A 401 ( 4.2A)
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
1G0  A 401 (-3.2A)
None
 0.64A 5hieC-4id7A:
26.2		 5hieC-4id7A:
30.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A 407
GLY A 409
VAL A 414
ALA A 427
LYS A 429
ASP A 534
 T28  A 701 ( 3.6A)
T28  A 701 ( 3.0A)
T28  A 701 (-4.7A)
T28  A 701 (-3.0A)
T28  A 701 ( 3.8A)
T28  A 701 ( 3.4A)
 0.94A 5hieC-4idtA:
24.4		 5hieC-4idtA:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7b POLO-LIKE KINASE

(Danio rerio) 		PF00069
(Pkinase) 		6 GLY A  48
ALA A  66
LYS A  68
PHE A 169
GLY A 179
ASP A 180
 None
 1.15A 5hieC-4j7bA:
23.2		 5hieC-4j7bA:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A  43
GLY A  45
PHE A  47
VAL A  50
LYS A  63
ASP A 175
 1UL  A 501 ( 4.1A)
1UL  A 501 ( 3.7A)
None
1UL  A 501 ( 4.9A)
None
1UL  A 501 (-4.2A)
 0.66A 5hieC-4l52A:
21.7		 5hieC-4l52A:
29.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A  43
GLY A  45
VAL A  50
ALA A  61
LYS A  63
ASP A 175
 1UL  A 501 ( 4.1A)
1UL  A 501 ( 3.7A)
1UL  A 501 ( 4.9A)
1UL  A 501 (-3.1A)
None
1UL  A 501 (-4.2A)
 0.82A 5hieC-4l52A:
21.7		 5hieC-4l52A:
29.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		6 GLY A  29
GLY A  31
VAL A  36
ALA A  49
LYS A  51
LEU A 150
 ANP  A 401 (-3.8A)
ANP  A 401 (-3.4A)
ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
ANP  A 401 (-4.8A)
 1.28A 5hieC-4m69A:
26.8		 5hieC-4m69A:
27.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		6 GLY A  29
GLY A  31
VAL A  36
ALA A  49
LYS A  51
THR A  95
 ANP  A 401 (-3.8A)
ANP  A 401 (-3.4A)
ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
ANP  A 401 (-3.8A)
 0.66A 5hieC-4m69A:
26.8		 5hieC-4m69A:
27.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		6 GLY A  29
VAL A  36
ALA A  49
LYS A  51
LEU A  74
THR A  95
 ANP  A 401 (-3.8A)
ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
None
ANP  A 401 (-3.8A)
 0.72A 5hieC-4m69A:
26.8		 5hieC-4m69A:
27.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  54
ALA A  67
LYS A  69
THR A 123
ASP A 191
 None
SIN  A 401 ( 3.7A)
None
None
None
 0.55A 5hieC-4o38A:
20.0		 5hieC-4o38A:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 GLY A 596
GLY A 598
VAL A 603
LYS A 642
THR A 687
 2TT  A1201 (-3.3A)
2TT  A1201 ( 4.4A)
2TT  A1201 (-4.2A)
2TT  A1201 ( 4.6A)
None
 0.50A 5hieC-4oliA:
26.0		 5hieC-4oliA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 904
GLY A 906
VAL A 911
ALA A 928
GLY A1040
ASP A1041
 2TT  A1202 ( 4.2A)
2TT  A1202 ( 3.8A)
2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
2TT  A1202 (-3.4A)
2TT  A1202 (-4.6A)
 0.83A 5hieC-4oliA:
26.0		 5hieC-4oliA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 904
GLY A 906
VAL A 911
ALA A 928
LYS A 930
ASP A1041
 2TT  A1202 ( 4.2A)
2TT  A1202 ( 3.8A)
2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
None
2TT  A1202 (-4.6A)
 0.77A 5hieC-4oliA:
26.0		 5hieC-4oliA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		6 GLY A  25
GLY A  27
VAL A  32
ALA A  45
LYS A  47
ASP A 159
 STU  A 601 (-3.5A)
STU  A 601 (-3.4A)
STU  A 601 ( 4.8A)
STU  A 601 (-3.2A)
STU  A 601 ( 3.7A)
STU  A 601 (-3.7A)
 0.94A 5hieC-4rewA:
23.8		 5hieC-4rewA:
20.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		5 GLY A  15
VAL A  22
ALA A  35
LYS A  37
THR A  81
 ACP  A1264 ( 4.2A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
ACP  A1264 (-4.5A)
 0.52A 5hieC-4ueuA:
26.9		 5hieC-4ueuA:
34.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uy9 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A 151
GLY A 153
VAL A 158
ALA A 169
LYS A 171
ASP A 294
 None
 0.98A 5hieC-4uy9A:
27.6		 5hieC-4uy9A:
30.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		5 GLY A 409
GLY A 411
VAL A 416
ALA A 428
THR A 474
 746  A 702 ( 3.5A)
746  A 702 (-3.0A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
746  A 702 (-3.7A)
 0.43A 5hieC-4y93A:
27.6		 5hieC-4y93A:
23.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 470
VAL A 477
ALA A 488
LYS A 490
THR A 539
ASP A 606
 4CV  A 801 ( 3.9A)
None
4CV  A 801 (-3.5A)
4CV  A 801 (-3.9A)
4CV  A 801 (-2.8A)
4CV  A 801 (-3.5A)
 0.98A 5hieC-4yffA:
25.7		 5hieC-4yffA:
31.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ynz SERINE/THREONINE-PRO
TEIN KINASE BRSK2

(Mus musculus) 		PF00069
(Pkinase) 		5 GLY A  27
VAL A  34
ALA A  47
LYS A  49
LEU A  80
 None
 0.46A 5hieC-4ynzA:
22.1		 5hieC-4ynzA:
26.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  32
GLY A  34
VAL A  39
ALA A  52
LYS A  54
ASP A 171
 GLY  A  32 ( 0.0A)
GLY  A  34 ( 0.0A)
VAL  A  39 (-0.6A)
ALA  A  52 (-0.0A)
LYS  A  54 ( 0.0A)
ASP  A 171 ( 0.5A)
 0.83A 5hieC-5d7aA:
25.8		 5hieC-5d7aA:
30.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8y TGF-BETA RECEPTOR
TYPE-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 251
GLY A 253
VAL A 258
ALA A 275
LYS A 277
LEU A 305
THR A 325
 STU  A 601 (-2.9A)
STU  A 601 ( 3.9A)
STU  A 601 (-4.0A)
STU  A 601 (-3.1A)
STU  A 601 (-2.4A)
STU  A 601 ( 3.8A)
STU  A 601 ( 3.7A)
 0.83A 5hieC-5e8yA:
25.3		 5hieC-5e8yA:
28.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8y TGF-BETA RECEPTOR
TYPE-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 251
PHE A 279
VAL A 258
ALA A 275
LYS A 277
LEU A 305
THR A 325
 STU  A 601 (-2.9A)
None
STU  A 601 (-4.0A)
STU  A 601 (-3.1A)
STU  A 601 (-2.4A)
STU  A 601 ( 3.8A)
STU  A 601 ( 3.7A)
 1.10A 5hieC-5e8yA:
25.3		 5hieC-5e8yA:
28.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8y TGF-BETA RECEPTOR
TYPE-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 251
VAL A 258
ALA A 275
LYS A 277
LEU A 305
THR A 325
ASP A 397
 STU  A 601 (-2.9A)
STU  A 601 (-4.0A)
STU  A 601 (-3.1A)
STU  A 601 (-2.4A)
STU  A 601 ( 3.8A)
STU  A 601 ( 3.7A)
STU  A 601 (-3.0A)
 0.64A 5hieC-5e8yA:
25.3		 5hieC-5e8yA:
28.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyk AURORA KINASE B-A

(Xenopus laevis) 		PF00069
(Pkinase) 		5 GLY A 100
VAL A 107
ALA A 120
LYS A 122
LEU A 154
 5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-2.6A)
5U5  A 401 (-4.8A)
 0.55A 5hieC-5eykA:
22.7		 5hieC-5eykA:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 904
VAL A 911
ALA A 928
LYS A 930
GLY A1040
ASP A1041
 5U3  A1200 ( 3.7A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
5U3  A1200 ( 4.9A)
5U3  A1200 ( 4.9A)
 0.70A 5hieC-5f1zA:
26.8		 5hieC-5f1zA:
29.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fd2 SERINE/THREONINE-PRO
TEIN KINASE B-RAF

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 GLY A 464
VAL A 471
ALA A 481
LYS A 483
LEU A 514
THR A 529
TRP A 531
PHE A 583
GLY A 593
 None
5XJ  A 801 (-4.6A)
5XJ  A 801 (-3.1A)
5XJ  A 801 (-3.8A)
5XJ  A 801 (-4.5A)
5XJ  A 801 (-3.4A)
5XJ  A 801 (-4.4A)
5XJ  A 801 (-4.3A)
5XJ  A 801 ( 3.7A)
 0.51A 5hieC-5fd2A:
35.1		 5hieC-5fd2A:
97.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fd2 SERINE/THREONINE-PRO
TEIN KINASE B-RAF

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 VAL A 471
ALA A 481
LYS A 483
LEU A 514
THR A 529
TRP A 531
PHE A 583
GLY A 593
ASP A 594
 5XJ  A 801 (-4.6A)
5XJ  A 801 (-3.1A)
5XJ  A 801 (-3.8A)
5XJ  A 801 (-4.5A)
5XJ  A 801 (-3.4A)
5XJ  A 801 (-4.4A)
5XJ  A 801 (-4.3A)
5XJ  A 801 ( 3.7A)
None
 0.70A 5hieC-5fd2A:
35.1		 5hieC-5fd2A:
97.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 GLY A 600
VAL A 607
ALA A 625
LYS A 627
THR A 674
 None
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.2A)
 0.46A 5hieC-5grnA:
21.1		 5hieC-5grnA:
28.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A  28
VAL A  30
ALA A  43
LYS A  45
THR A  82
ASP A 151
 None
032  A 401 (-4.4A)
032  A 401 (-3.2A)
032  A 401 (-4.4A)
032  A 401 (-3.7A)
032  A 401 (-4.6A)
 0.91A 5hieC-5hesA:
20.6		 5hieC-5hesA:
31.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o2c SERINE/THREONINE-PRO
TEIN KINASE WNK3

(Homo sapiens) 		PF00069
(Pkinase)
PF12202
(OSR1_C) 		6 GLY A 154
VAL A 161
ALA A 174
THR A 227
PHE A 282
GLY A 293
 None
None
GOL  A 604 ( 3.8A)
GOL  A 604 (-3.9A)
GOL  A 604 ( 4.5A)
GOL  A 604 ( 4.6A)
 0.73A 5hieC-5o2cA:
24.8		 5hieC-5o2cA:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5okt CASEIN KINASE I
ISOFORM DELTA

(Homo sapiens) 		no annotation 6 GLY C  16
GLY C  18
PHE C  20
ALA C  36
LYS C  38
ASP C 149
 None
None
None
9XK  C 301 ( 3.7A)
9XK  C 301 ( 4.6A)
None
 0.90A 5hieC-5oktC:
20.7		 5hieC-5oktC:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5to3 PROTHROMBIN,THROMBOM
ODULIN

(Homo sapiens) 		PF00089
(Trypsin)
PF09064
(Tme5_EGF_like) 		6 GLY B 222
GLY B 238
VAL B 240
ALA B 215
LEU B 180
GLY B 151
 None
None
None
0G6  B 501 (-3.4A)
None
None
 1.37A 5hieC-5to3B:
undetectable		 5hieC-5to3B:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A 117
VAL A 124
ALA A 137
THR A 187
PHE A 240
GLY A 250
 H8H  A 401 ( 3.7A)
H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
None
 0.75A 5hieC-5vcxA:
21.2		 5hieC-5vcxA:
27.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 124
ALA A 137
THR A 187
PHE A 240
GLY A 250
ASP A 251
 H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
None
EDO  A 402 ( 2.9A)
 0.81A 5hieC-5vcxA:
21.2		 5hieC-5vcxA:
27.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vdk WEE1-LIKE PROTEIN
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A 219
GLY A 221
VAL A 226
ALA A 239
PHE A 346
GLY A 379
 8X7  A 501 ( 3.8A)
8X7  A 501 (-3.4A)
8X7  A 501 ( 4.5A)
8X7  A 501 ( 3.7A)
8X7  A 501 (-3.7A)
None
 0.81A 5hieC-5vdkA:
22.4		 5hieC-5vdkA:
29.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5

(Homo sapiens) 		no annotation 6 GLY A 687
GLY A 689
VAL A 694
ALA A 707
LYS A 709
ASP A 822
 9E1  A1001 ( 3.4A)
9E1  A1001 (-2.9A)
9E1  A1001 ( 4.0A)
9E1  A1001 (-3.5A)
9E1  A1001 (-2.8A)
9E1  A1001 (-3.6A)
 0.82A 5hieC-5vilA:
4.7		 5hieC-5vilA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2

(Homo sapiens) 		no annotation 6 GLY A  27
VAL A  32
ALA A  45
LYS A  47
LEU A  79
THR A  95
 None
9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.3A)
9WS  A 401 (-4.9A)
9WS  A 401 (-3.2A)
 0.72A 5hieC-5w5jA:
26.9		 5hieC-5w5jA:
29.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 6 GLY A 892
GLY A 894
VAL A 899
ALA A 917
LYS A 919
THR A 963
 ANP  A1201 ( 3.8A)
ANP  A1201 (-2.8A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
ANP  A1201 (-3.9A)
 0.87A 5hieC-5wnoA:
25.5		 5hieC-5wnoA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 6 GLY A 892
PHE A 921
VAL A 899
ALA A 917
LEU A 947
THR A 963
 ANP  A1201 ( 3.8A)
None
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-4.7A)
ANP  A1201 (-3.9A)
 1.17A 5hieC-5wnoA:
25.5		 5hieC-5wnoA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x1t PPKA-294

(Serratia sp.
FS14) 		no annotation 6 GLY A  30
GLY A  35
VAL A  37
ALA A  50
LEU A 102
THR A 118
 ADP  A 401 (-3.4A)
None
ADP  A 401 ( 4.5A)
ADP  A 401 (-3.4A)
None
ADP  A 401 (-4.1A)
 1.20A 5hieC-5x1tA:
21.4		 5hieC-5x1tA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x1t PPKA-294

(Serratia sp.
FS14) 		no annotation 6 GLY A  35
PHE A  86
VAL A  37
ALA A  50
LEU A 102
THR A 118
 None
None
ADP  A 401 ( 4.5A)
ADP  A 401 (-3.4A)
None
ADP  A 401 (-4.1A)
 1.32A 5hieC-5x1tA:
21.4		 5hieC-5x1tA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xqo PCRGLX PROTEIN

(Penicillium
chrysogenum) 		no annotation 6 GLY A 377
GLY A 360
ALA A 291
LEU A 409
PHE A 401
GLY A 408
 None
 1.29A 5hieC-5xqoA:
undetectable		 5hieC-5xqoA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cth CONCANAVALIN A-LIKE
LECTIN PROTEIN
KINASE FAMILY
PROTEIN

(Theobroma cacao) 		no annotation 6 GLY A 276
PHE A 280
VAL A 283
ALA A 296
LYS A 298
GLY A 410
 FE7  A 601 ( 3.7A)
None
FE7  A 601 ( 4.3A)
FE7  A 601 (-3.3A)
FE7  A 601 (-3.6A)
FE7  A 601 ( 4.1A)
 0.76A 5hieC-6cthA:
22.7		 5hieC-6cthA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f2e GLUTATHIONE
S-TRANSFERASE

(Sphingomonas
paucimobilis) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 ILE A   5
VAL A 168
ASN A  66
PHE A 109
 None
None
GSH  A 210 (-4.1A)
None
 0.93A 5hieC-1f2eA:
0.0		 5hieC-1f2eA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fft UBIQUINOL OXIDASE

(Escherichia
coli) 		PF00510
(COX3) 		4 ILE C 177
VAL C 189
PHE C 186
PHE C  78
 None
 0.96A 5hieC-1fftC:
3.2		 5hieC-1fftC:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hkw DIAMINOPIMELATE
DECARBOXYLASE

(Mycobacterium
tuberculosis) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		4 ILE A 154
VAL A 196
ILE A 142
PHE A 200
 None
 0.98A 5hieC-1hkwA:
0.0		 5hieC-1hkwA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hkw DIAMINOPIMELATE
DECARBOXYLASE

(Mycobacterium
tuberculosis) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		4 VAL A  79
ILE A 305
ASN A 342
PHE A  74
 None
 0.87A 5hieC-1hkwA:
0.0		 5hieC-1hkwA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i8q HYALURONATE LYASE

(Streptococcus
agalactiae) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		4 VAL A 409
PHE A 408
ILE A 365
PHE A 415
 None
 0.85A 5hieC-1i8qA:
0.3		 5hieC-1i8qA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kt1 FK506-BINDING
PROTEIN FKBP51

(Saimiri
boliviensis) 		PF00254
(FKBP_C)
PF00515
(TPR_1)
PF13181
(TPR_8) 		4 ILE A 242
VAL A 190
ILE A 198
CYH A 215
 None
 0.97A 5hieC-1kt1A:
0.0		 5hieC-1kt1A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l6r HYPOTHETICAL PROTEIN
TA0175

(Thermoplasma
acidophilum) 		PF08282
(Hydrolase_3) 		4 VAL A  49
PHE A  71
ILE A  77
ASN A 146
 None
 1.00A 5hieC-1l6rA:
undetectable		 5hieC-1l6rA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n3y INTEGRIN ALPHA-X

(Homo sapiens) 		PF00092
(VWA) 		4 ILE A 159
VAL A 269
ILE A 306
PHE A 300
 None
 0.98A 5hieC-1n3yA:
undetectable		 5hieC-1n3yA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1om9 ADP-RIBOSYLATION
FACTOR BINDING
PROTEIN GGA1

(Homo sapiens) 		PF02883
(Alpha_adaptinC2) 		4 VAL A 545
ILE A 592
ASN A 622
PHE A 560
 None
 0.94A 5hieC-1om9A:
0.0		 5hieC-1om9A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Escherichia
coli) 		PF00311
(PEPcase) 		4 ILE A 263
VAL A 486
ILE A 461
ASN A 256
 None
 0.98A 5hieC-1qb4A:
1.5		 5hieC-1qb4A:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhm PYRUVATE
FORMATE-LYASE

(Escherichia
coli) 		PF02901
(PFL-like) 		4 ILE A1392
VAL A1349
ILE A1373
PHE A1354
 None
 1.00A 5hieC-1qhmA:
0.0		 5hieC-1qhmA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rz2 CONSERVED
HYPOTHETICAL PROTEIN
BA4783

(Bacillus
anthracis) 		PF04203
(Sortase) 		4 ILE A  52
VAL A 128
ILE A  96
PHE A 172
 None
 0.83A 5hieC-1rz2A:
undetectable		 5hieC-1rz2A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s5j DNA POLYMERASE I

(Sulfolobus
solfataricus) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 ILE A 416
ILE A 230
ASN A 378
PHE A 317
 None
 0.94A 5hieC-1s5jA:
undetectable		 5hieC-1s5jA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5k MICROTUBULE-ASSOCIAT
ED PROTEIN, RP/EB
FAMILY, MEMBER 1

(Mus musculus) 		PF00307
(CH) 		4 ILE A  28
VAL A  54
ASN A  18
PHE A  56
 None
 0.91A 5hieC-1v5kA:
undetectable		 5hieC-1v5kA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vka MICROTUBULE-ASSOCIAT
ED PROTEIN RP/EB
FAMILY MEMBER 1

(Homo sapiens) 		PF00307
(CH) 		4 ILE A  35
VAL A  61
ASN A  25
PHE A  63
 None
 0.79A 5hieC-1vkaA:
undetectable		 5hieC-1vkaA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wpw 3-ISOPROPYLMALATE
DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF00180
(Iso_dh) 		4 ILE A  61
VAL A 277
PHE A 252
ILE A  67
 None
 0.83A 5hieC-1wpwA:
undetectable		 5hieC-1wpwA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyo MICROTUBULE-ASSOCIAT
ED PROTEIN RP/EB
FAMILY MEMBER 3

(Homo sapiens) 		PF00307
(CH) 		4 ILE A  42
VAL A  68
ASN A  32
PHE A  70
 None
 0.71A 5hieC-1wyoA:
undetectable		 5hieC-1wyoA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xzw PURPLE ACID
PHOSPHATASE

(Ipomoea batatas) 		PF00149
(Metallophos)
PF14008
(Metallophos_C)
PF16656
(Pur_ac_phosph_N) 		4 VAL A 282
PHE A 319
ASN A 334
PHE A 310
 None
 0.99A 5hieC-1xzwA:
undetectable		 5hieC-1xzwA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygp YEAST GLYCOGEN
PHOSPHORYLASE

(Saccharomyces
cerevisiae) 		PF00343
(Phosphorylase) 		4 VAL A 773
ILE A 666
ASN A 624
PHE A 581
 None
 0.99A 5hieC-1ygpA:
undetectable		 5hieC-1ygpA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csu 457AA LONG
HYPOTHETICAL PROTEIN

(Pyrococcus
horikoshii) 		PF13380
(CoA_binding_2)
PF13607
(Succ_CoA_lig) 		4 VAL A  89
ILE A  14
CYH A 129
ASN A 140
 None
 0.96A 5hieC-2csuA:
undetectable		 5hieC-2csuA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d8x PROTEIN PINCH

(Homo sapiens) 		PF00412
(LIM) 		4 ILE A  16
VAL A  40
PHE A  32
ILE A  20
 None
 0.93A 5hieC-2d8xA:
undetectable		 5hieC-2d8xA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dby GTP-BINDING PROTEIN

(Thermus
thermophilus) 		PF01926
(MMR_HSR1)
PF06071
(YchF-GTPase_C) 		4 VAL A   4
ILE A  76
ASN A  19
PHE A  73
 None
 0.98A 5hieC-2dbyA:
undetectable		 5hieC-2dbyA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dt7 SPLICING FACTOR 3
SUBUNIT 1

(Homo sapiens) 		PF01805
(Surp) 		4 ILE B 153
VAL B 166
ILE B 159
PHE B 162
 None
 0.96A 5hieC-2dt7B:
undetectable		 5hieC-2dt7B:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ete OXALATE OXIDASE 1

(Hordeum vulgare) 		PF00190
(Cupin_1) 		4 VAL A 106
PHE A 138
ASN A 154
PHE A 129
 None
 0.94A 5hieC-2eteA:
undetectable		 5hieC-2eteA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fpr HISTIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
HISB

(Escherichia
coli) 		PF08645
(PNK3P) 		4 ILE A  93
VAL A  37
ILE A   9
ASN A  75
 None
 0.84A 5hieC-2fprA:
undetectable		 5hieC-2fprA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Mycobacterium
tuberculosis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 ILE A 357
ILE A 261
CYH A 194
ASN A 400
 None
 0.89A 5hieC-2gp6A:
undetectable		 5hieC-2gp6A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hxd DCTP DEAMINASE,
DUMP-FORMING

(Methanocaldococcus
jannaschii) 		PF00692
(dUTPase) 		4 ILE A 161
VAL A  12
ILE A 104
PHE A  22
 None
 0.98A 5hieC-2hxdA:
undetectable		 5hieC-2hxdA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j4g HYALURONOGLUCOSAMINI
DASE

(Bacteroides
thetaiotaomicron) 		PF02838
(Glyco_hydro_20b)
PF07555
(NAGidase) 		4 ILE A 244
VAL A 342
PHE A 136
CYH A 278
 None
NB1  A1590 ( 4.9A)
None
NB1  A1590 (-3.4A)
 0.94A 5hieC-2j4gA:
undetectable		 5hieC-2j4gA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j86 PROTEIN
SERINE-THREONINE
PHOSPHATASE

(Synechococcus
elongatus) 		PF13672
(PP2C_2) 		4 ILE A 175
VAL A 236
PHE A  30
ILE A 103
 None
 0.94A 5hieC-2j86A:
undetectable		 5hieC-2j86A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kk4 UNCHARACTERIZED
PROTEIN AF_2094

(Archaeoglobus
fulgidus) 		no annotation 4 VAL A  33
PHE A  37
ILE A  22
PHE A  18
 None
 0.97A 5hieC-2kk4A:
undetectable		 5hieC-2kk4A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oqz SORTASE B

(Bacillus
anthracis) 		PF04203
(Sortase) 		4 ILE A  52
VAL A 128
ILE A  96
PHE A 172
 None
 0.84A 5hieC-2oqzA:
undetectable		 5hieC-2oqzA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p5m ARGININE REPRESSOR

(Bacillus
subtilis) 		PF02863
(Arg_repressor_C) 		4 ILE A 131
PHE A  84
ILE A  87
CYH A 123
 None
 0.94A 5hieC-2p5mA:
undetectable		 5hieC-2p5mA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pg0 ACYL-COA
DEHYDROGENASE

(Geobacillus
kaustophilus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 ILE A 362
VAL A 308
ILE A 254
PHE A 304
 None
 0.96A 5hieC-2pg0A:
undetectable		 5hieC-2pg0A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ppv UNCHARACTERIZED
PROTEIN

(Staphylococcus
epidermidis) 		PF01933
(UPF0052) 		4 ILE A  45
VAL A 114
ILE A  61
ASN A  99
 None
 0.96A 5hieC-2ppvA:
undetectable		 5hieC-2ppvA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q0t PUTATIVE
GAMMA-CARBOXYMUCONOL
ACTONE DECARBOXYLASE
SUBUNIT

(Paraburkholderia
xenovorans) 		PF02627
(CMD) 		4 ILE A  83
PHE A 190
ILE A  63
PHE A 195
 None
 0.84A 5hieC-2q0tA:
undetectable		 5hieC-2q0tA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qfr PURPLE ACID
PHOSPHATASE

(Phaseolus
vulgaris) 		PF00149
(Metallophos)
PF14008
(Metallophos_C)
PF16656
(Pur_ac_phosph_N) 		4 VAL A 283
PHE A 320
ASN A 335
PHE A 311
 None
 0.96A 5hieC-2qfrA:
undetectable		 5hieC-2qfrA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qgy ENOLASE FROM THE
ENVIRONMENTAL GENOME
SHOTGUN SEQUENCING
OF THE SARGASSO SEA

(-) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ILE A 284
VAL A 247
ILE A 295
CYH A 316
 None
 0.87A 5hieC-2qgyA:
undetectable		 5hieC-2qgyA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2quq CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
B

(Saccharomyces
cerevisiae) 		PF16846
(Cep3) 		4 VAL A 431
PHE A 415
ASN A  67
PHE A 469
 None
 0.87A 5hieC-2quqA:
2.7		 5hieC-2quqA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r8u MICROTUBULE-ASSOCIAT
ED PROTEIN RP/EB
FAMILY MEMBER 1

(Homo sapiens) 		PF00307
(CH) 		4 ILE A  35
VAL A  61
ASN A  25
PHE A  63
 None
 0.81A 5hieC-2r8uA:
undetectable		 5hieC-2r8uA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vo9 L-ALANYL-D-GLUTAMATE
PEPTIDASE

(Listeria phage
A500) 		PF13539
(Peptidase_M15_4) 		4 ILE A  41
ILE A   9
CYH A  89
ASN A  93
 None
 0.97A 5hieC-2vo9A:
undetectable		 5hieC-2vo9A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w37 ORNITHINE
CARBAMOYLTRANSFERASE
, CATABOLIC

(Lactobacillus
hilgardii) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 ILE A 205
PHE A 197
ILE A 219
PHE A 165
 None
 0.85A 5hieC-2w37A:
undetectable		 5hieC-2w37A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w61 GLYCOLIPID-ANCHORED
SURFACE PROTEIN 2

(Saccharomyces
cerevisiae) 		PF03198
(Glyco_hydro_72)
PF07983
(X8) 		4 ILE A 209
VAL A 230
PHE A 229
ILE A 194
 None
 1.00A 5hieC-2w61A:
undetectable		 5hieC-2w61A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wba TRYPANOTHIONE
REDUCTASE

(Trypanosoma
brucei) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 VAL A 268
ILE A 169
ASN A 223
PHE A 270
 None
None
NDP  A1496 (-4.0A)
None
 0.80A 5hieC-2wbaA:
undetectable		 5hieC-2wbaA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yps SORTING NEXIN-3

(Homo sapiens) 		PF00787
(PX) 		4 VAL A  67
PHE A 144
ILE A 126
ASN A  56
 None
 0.98A 5hieC-2ypsA:
undetectable		 5hieC-2ypsA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9i HOMOCITRATE SYNTHASE

(Thermus
thermophilus) 		PF00682
(HMGL-like) 		4 ILE A 204
VAL A 269
ILE A 222
PHE A  17
 None
 0.93A 5hieC-3a9iA:
undetectable		 5hieC-3a9iA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayx MEMBRANE-BOUND
HYDROGENASE LARGE
SUBUNIT
MEMBRANE-BOUND
HYDROGENASE SMALL
SUBUNIT

(Hydrogenovibrio
marinus) 		PF00374
(NiFeSe_Hases)
PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		4 ILE B 252
VAL A 262
PHE A 261
PHE A 224
 SF4  B 309 ( 4.1A)
None
None
None
 0.99A 5hieC-3ayxB:
undetectable		 5hieC-3ayxB:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE

(Homo sapiens) 		PF16113
(ECH_2) 		4 ILE A 280
PHE A 175
ILE A 309
ASN A 300
 None
 0.93A 5hieC-3bptA:
undetectable		 5hieC-3bptA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3v ARACHIN ARAH3
ISOFORM

(Arachis
hypogaea) 		PF00190
(Cupin_1) 		4 ILE A  21
VAL A 467
ASN A 184
PHE A 469
 None
 0.99A 5hieC-3c3vA:
0.8		 5hieC-3c3vA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c6q SUGAR ABC
TRANSPORTER,
PERIPLASMIC
SUGAR-BINDING
PROTEIN

(Thermotoga
maritima) 		no annotation 4 VAL B 126
PHE B 186
ASN B 105
PHE B 145
 None
 0.98A 5hieC-3c6qB:
undetectable		 5hieC-3c6qB:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3chl ALPHA-14 GIARDIN

(Giardia
intestinalis) 		PF00191
(Annexin) 		4 ILE A 111
VAL A 253
ILE A 268
PHE A 249
 None
 0.93A 5hieC-3chlA:
undetectable		 5hieC-3chlA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dcp HISTIDINOL-PHOSPHATA
SE

(Listeria
monocytogenes) 		PF02811
(PHP)
PF13263
(PHP_C) 		4 VAL A 243
ILE A 182
CYH A 233
PHE A 223
 None
 0.92A 5hieC-3dcpA:
undetectable		 5hieC-3dcpA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3enh UNCHARACTERIZED
PROTEIN MJ0187

(Methanocaldococcus
jannaschii) 		PF08617
(CGI-121) 		4 VAL C 138
ILE C 114
CYH C  87
PHE C 126
 None
 0.96A 5hieC-3enhC:
undetectable		 5hieC-3enhC:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqn GLUCAN
1,3-BETA-GLUCOSIDASE

(Phanerochaete
chrysosporium) 		PF12708
(Pectate_lyase_3) 		4 VAL A 229
ILE A 283
CYH A 259
PHE A 222
 None
 0.92A 5hieC-3eqnA:
undetectable		 5hieC-3eqnA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5k PEPTIDE DEFORMYLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01327
(Pep_deformylase) 		4 VAL A 102
ILE A 154
CYH A 164
PHE A 127
 None
 0.90A 5hieC-3g5kA:
undetectable		 5hieC-3g5kA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h11 CASP8 AND FADD-LIKE
APOPTOSIS REGULATOR

(Homo sapiens) 		PF00656
(Peptidase_C14) 		4 ILE A 260
VAL A 309
PHE A 355
PHE A 271
 None
 0.99A 5hieC-3h11A:
undetectable		 5hieC-3h11A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hnp OXIDOREDUCTASE

(Bacillus cereus) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 ILE A  86
VAL A  30
ILE A  66
PHE A   7
 None
 0.75A 5hieC-3hnpA:
undetectable		 5hieC-3hnpA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i23 OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY

(Enterococcus
faecalis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 ILE A  86
VAL A  30
ILE A  66
PHE A   7
 None
 0.77A 5hieC-3i23A:
undetectable		 5hieC-3i23A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ivu HOMOCITRATE
SYNTHASE,
MITOCHONDRIAL

(Schizosaccharomyces
pombe) 		PF00682
(HMGL-like) 		4 ILE A 233
VAL A 298
ILE A 251
PHE A  48
 None
 0.95A 5hieC-3ivuA:
undetectable		 5hieC-3ivuA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jar MICROTUBULE-ASSOCIAT
ED PROTEIN RP/EB
FAMILY MEMBER 3

(Homo sapiens) 		no annotation 4 ILE N  35
VAL N  61
ASN N  25
PHE N  63
 None
 0.83A 5hieC-3jarN:
undetectable		 5hieC-3jarN:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kt4 PKHD-TYPE
HYDROXYLASE TPA1

(Saccharomyces
cerevisiae) 		PF10637
(Ofd1_CTDD)
PF13661
(2OG-FeII_Oxy_4) 		4 ILE A 241
VAL A 132
ILE A 168
PHE A 128
 None
 0.80A 5hieC-3kt4A:
undetectable		 5hieC-3kt4A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lg6 PUTATIVE GLUTATHIONE
TRANSFERASE

(Coccidioides
immitis) 		PF13409
(GST_N_2)
PF14497
(GST_C_3) 		4 VAL A 204
PHE A 168
ILE A 174
ASN A 117
 None
 0.96A 5hieC-3lg6A:
undetectable		 5hieC-3lg6A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nm1 THIAMINE
BIOSYNTHETIC
BIFUNCTIONAL ENZYME

([Candida]
glabrata) 		PF02110
(HK)
PF02581
(TMP-TENI) 		4 ILE A 257
VAL A 412
ILE A 476
PHE A 486
 None
 0.75A 5hieC-3nm1A:
undetectable		 5hieC-3nm1A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o5d PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5

(Homo sapiens) 		PF00254
(FKBP_C) 		4 ILE A 122
VAL A  55
CYH A 107
PHE A  79
 None
 0.98A 5hieC-3o5dA:
undetectable		 5hieC-3o5dA:
22.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ILE A 355
ILE A 419
CYH A 424
PHE A 487
 SM5  A   1 (-4.3A)
SM5  A   1 ( 4.3A)
SM5  A   1 ( 4.4A)
None
 0.69A 5hieC-3omvA:
34.8		 5hieC-3omvA:
77.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ILE A 355
PHE A 408
ILE A 419
ASN A 472
 SM5  A   1 (-4.3A)
None
SM5  A   1 ( 4.3A)
SM5  A   1 (-3.9A)
 0.70A 5hieC-3omvA:
34.8		 5hieC-3omvA:
77.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ILE A 355
PHE A 408
ILE A 419
CYH A 424
 SM5  A   1 (-4.3A)
None
SM5  A   1 ( 4.3A)
SM5  A   1 ( 4.4A)
 0.46A 5hieC-3omvA:
34.8		 5hieC-3omvA:
77.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 396
PHE A 408
ILE A 419
ASN A 472
 None
None
SM5  A   1 ( 4.3A)
SM5  A   1 (-3.9A)
 0.98A 5hieC-3omvA:
34.8		 5hieC-3omvA:
77.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opu SPAP

(Streptococcus
mutans) 		PF16364
(Antigen_C) 		4 ILE A1364
VAL A1445
ILE A1368
PHE A1441
 None
 0.97A 5hieC-3opuA:
undetectable		 5hieC-3opuA:
20.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		4 ILE A 557
PHE A 611
ILE A 623
PHE A 695
 STU  A   1 (-4.1A)
None
None
None
 1.00A 5hieC-3ppzA:
28.1		 5hieC-3ppzA:
38.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qr3 ENDOGLUCANASE EG-II

(Trichoderma
reesei) 		PF00150
(Cellulase) 		4 VAL A 290
PHE A  59
ILE A   9
ASN A 105
 None
 0.93A 5hieC-3qr3A:
undetectable		 5hieC-3qr3A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rip GAMMA-TUBULIN
COMPLEX COMPONENT 4

(Homo sapiens) 		PF04130
(Spc97_Spc98) 		4 VAL A 487
ILE A 585
ASN A 651
PHE A 579
 None
None
None
GOL  A 679 ( 4.3A)
 0.86A 5hieC-3ripA:
undetectable		 5hieC-3ripA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rpw ABC TRANSPORTER

(Rhodopseudomonas
palustris) 		PF13416
(SBP_bac_8) 		4 PHE A 336
ILE A 196
ASN A 256
PHE A 177
 None
 0.97A 5hieC-3rpwA:
undetectable		 5hieC-3rpwA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s1s RESTRICTION
ENDONUCLEASE BPUSI

(Bacillus
pumilus) 		PF02384
(N6_Mtase)
PF15516
(BpuSI_N) 		4 VAL A  48
ILE A 163
ASN A 113
PHE A  61
 None
 0.87A 5hieC-3s1sA:
undetectable		 5hieC-3s1sA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u50 TELOMERASE-ASSOCIATE
D PROTEIN 82

(Tetrahymena
thermophila) 		PF08646
(Rep_fac-A_C) 		4 ILE C 513
VAL C 591
ILE C 520
PHE C 653
 None
 0.93A 5hieC-3u50C:
undetectable		 5hieC-3u50C:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vgf MALTO-OLIGOSYLTREHAL
OSE TREHALOHYDROLASE

(Sulfolobus
solfataricus) 		PF00128
(Alpha-amylase)
PF09071
(Alpha-amyl_C) 		4 VAL A 246
ILE A 138
ASN A 191
PHE A 249
 None
None
GLC  A 604 ( 4.5A)
None
 0.89A 5hieC-3vgfA:
undetectable		 5hieC-3vgfA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vpz GLUCOKINASE

(Pseudoalteromonas
sp. AS-131) 		PF02685
(Glucokinase) 		4 ILE A  11
VAL A  84
ILE A  16
CYH A 324
 None
 0.96A 5hieC-3vpzA:
undetectable		 5hieC-3vpzA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdr ALCOHOL
DEHYDROGENASE DOMAIN
OF THE BIFUNCTIONAL
ACETALDEHYDE
DEHYDROGENASE

(Parageobacillus
thermoglucosidasius) 		PF00465
(Fe-ADH) 		4 ILE A 728
VAL A 824
ILE A 750
PHE A 740
 None
 0.74A 5hieC-3zdrA:
undetectable		 5hieC-3zdrA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zkb DNA GYRASE SUBUNIT B

(Mycobacterium
tuberculosis) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		4 ILE A 308
VAL A 387
ILE A 358
PHE A 383
 None
 0.99A 5hieC-3zkbA:
undetectable		 5hieC-3zkbA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zth STU0660

(Streptococcus
thermophilus) 		PF16813
(Cas_St_Csn2) 		4 ILE A 246
VAL A 202
PHE A 234
PHE A 237
 None
 0.95A 5hieC-3zthA:
undetectable		 5hieC-3zthA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5p PROTEIN MXIA

(Shigella
flexneri) 		PF00771
(FHIPEP) 		4 ILE A 542
PHE A 643
ILE A 666
CYH A 580
 None
MLY  A 641 ( 4.5A)
None
None
 0.99A 5hieC-4a5pA:
undetectable		 5hieC-4a5pA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ain GLYCINE BETAINE
TRANSPORTER BETP

(Corynebacterium
glutamicum) 		PF02028
(BCCT) 		4 ILE A 238
VAL A 109
ILE A 199
PHE A 106
 None
 0.98A 5hieC-4ainA:
undetectable		 5hieC-4ainA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aoa BETA-PHENYLALANINE
AMINOTRANSFERASE

(Variovorax
paradoxus) 		PF00202
(Aminotran_3) 		4 VAL A 401
ILE A 412
ASN A 344
PHE A 351
 None
 0.93A 5hieC-4aoaA:
undetectable		 5hieC-4aoaA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ars HISTIDINE ACID
PHOSPHATASE

(Hafnia alvei) 		PF00328
(His_Phos_2) 		4 ILE A  15
VAL A 402
ILE A 313
ASN A 298
 None
 1.00A 5hieC-4arsA:
undetectable		 5hieC-4arsA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7p RALF

(Legionella
pneumophila) 		PF01369
(Sec7) 		4 ILE A  36
VAL A  58
ILE A  24
PHE A  76
 None
 0.91A 5hieC-4c7pA:
undetectable		 5hieC-4c7pA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czx PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3

(Neurospora
crassa) 		no annotation 5 ILE A  83
VAL B 626
PHE B 625
ASN A  34
PHE A  59
 None
 1.47A 5hieC-4czxA:
undetectable		 5hieC-4czxA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fva 5'-TYROSYL-DNA
PHOSPHODIESTERASE

(Caenorhabditis
elegans) 		PF03372
(Exo_endo_phos) 		4 VAL A 122
ILE A 189
ASN A 261
PHE A 267
 None
 0.71A 5hieC-4fvaA:
undetectable		 5hieC-4fvaA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzy EXODEOXYRIBONUCLEASE
10

(Escherichia
coli) 		PF00929
(RNase_T) 		4 ILE A 142
VAL A  88
ILE A   5
PHE A  84
 None
 0.92A 5hieC-4fzyA:
undetectable		 5hieC-4fzyA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gew 5'-TYROSYL-DNA
PHOSPHODIESTERASE

(Caenorhabditis
elegans) 		PF03372
(Exo_endo_phos)
PF14555
(UBA_4) 		4 VAL A 122
ILE A 189
ASN A 261
PHE A 267
 None
 0.72A 5hieC-4gewA:
undetectable		 5hieC-4gewA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6k AMIDOHYDROLASE
FAMILY PROTEIN

(Acinetobacter
baumannii) 		PF04909
(Amidohydro_2) 		4 ILE A 248
ILE A 222
ASN A 210
PHE A 217
 None
 0.98A 5hieC-4i6kA:
undetectable		 5hieC-4i6kA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i9y E3 SUMO-PROTEIN
LIGASE RANBP2

(Homo sapiens) 		PF00160
(Pro_isomerase) 		4 ILE A  67
VAL A 139
ILE A 156
CYH A  40
 None
 1.00A 5hieC-4i9yA:
undetectable		 5hieC-4i9yA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j1y COMPLEMENT C1S
SUBCOMPONENT

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		4 ILE A 548
VAL A 492
ILE A 446
PHE A 454
 None
 0.96A 5hieC-4j1yA:
0.4		 5hieC-4j1yA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jb3 HALOACID
DEHALOGENASE-LIKE
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF13419
(HAD_2) 		4 ILE A  26
VAL A 114
PHE A 113
PHE A  84
 None
 0.98A 5hieC-4jb3A:
undetectable		 5hieC-4jb3A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcl CYCLOMALTODEXTRIN
GLUCANOTRANSFERASE

(Paenibacillus
macerans) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		5 ILE A 318
VAL A 516
ILE A 502
ASN A 275
PHE A 580
 None
None
None
EDO  A 721 ( 4.4A)
None
 1.45A 5hieC-4jclA:
undetectable		 5hieC-4jclA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jqt PUTATIVE GLYCOSYL
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF06439
(DUF1080) 		4 ILE A 156
ILE A 182
ASN A 171
PHE A 108
 EDO  A 505 ( 4.4A)
None
None
None
 0.98A 5hieC-4jqtA:
undetectable		 5hieC-4jqtA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k7g 3-HYDROXYPROLINE
DEHYDRATSE

(Agrobacterium
vitis) 		PF05544
(Pro_racemase) 		4 ILE B 273
VAL B 244
CYH B 291
PHE B 174
 None
 0.87A 5hieC-4k7gB:
0.4		 5hieC-4k7gB:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpp PUTATIVE
UNCHARACTERIZED
PROTEIN

(Archaeoglobus
fulgidus) 		PF01699
(Na_Ca_ex) 		4 ILE A  13
VAL A  81
ILE A 220
PHE A 227
 None
 0.97A 5hieC-4kppA:
undetectable		 5hieC-4kppA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kqn D-HYDANTOINASE

(Bacillus sp.
AR9) 		PF01979
(Amidohydro_1) 		4 ILE A 348
VAL A 438
ASN A 416
PHE A  83
 ILE  A 348 ( 0.4A)
VAL  A 438 ( 0.6A)
ASN  A 416 ( 0.6A)
PHE  A  83 ( 1.3A)
 0.96A 5hieC-4kqnA:
undetectable		 5hieC-4kqnA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ksf MALONYL-COA
DECARBOXYLASE

(Agrobacterium
vitis) 		PF05292
(MCD)
PF17408
(MCD_N) 		4 ILE A 197
VAL A 286
ILE A 266
PHE A 215
 None
 0.97A 5hieC-4ksfA:
undetectable		 5hieC-4ksfA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m64 MELIBIOSE CARRIER
PROTEIN

(Salmonella
enterica) 		PF13347
(MFS_2) 		4 ILE A 250
VAL A 390
ASN A 244
PHE A 386
 None
 0.98A 5hieC-4m64A:
undetectable		 5hieC-4m64A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mix PUTATIVE
INSECTICIDAL TOXIN

(Photorhabdus
asymbiotica) 		PF04488
(Gly_transf_sug) 		4 ILE A2204
VAL A2223
ILE A2226
PHE A2218
 None
 0.91A 5hieC-4mixA:
undetectable		 5hieC-4mixA:
21.91