SIMILAR PATTERNS OF AMINO ACIDS FOR 5HIE_B_P06B801_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bg4 ENDO-1,4-BETA-XYLANA
SE

(Penicillium
simplicissimum) 		PF00331
(Glyco_hydro_10) 		4 ILE A 205
GLY A 204
LEU A 109
PHE A 145
 None
 0.85A 5hieB-1bg4A:
undetectable		 5hieB-1bg4A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dqs PROTEIN
(3-DEHYDROQUINATE
SYNTHASE)

(Aspergillus
nidulans) 		PF01761
(DHQ_synthase) 		4 ILE A 293
GLY A 294
LEU A 141
PHE A 188
 None
 0.82A 5hieB-1dqsA:
undetectable		 5hieB-1dqsA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1k ADRENODOXIN
REDUCTASE

(Bos taurus) 		PF07992
(Pyr_redox_2) 		4 ILE A 336
LEU A 133
PHE A  49
ASP A 106
 FAD  A 801 ( 4.9A)
None
None
None
 0.77A 5hieB-1e1kA:
undetectable		 5hieB-1e1kA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e8t HEMAGGLUTININ-NEURAM
INIDASE

(Avian
avulavirus 1) 		PF00423
(HN) 		4 GLY A 366
LEU A 388
PHE A 292
ASP A 327
 None
 0.88A 5hieB-1e8tA:
undetectable		 5hieB-1e8tA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f39 REPRESSOR PROTEIN CI

(Escherichia
virus Lambda) 		PF00717
(Peptidase_S24) 		4 ILE A 181
GLY A 223
PHE A 202
ASP A 178
 None
 0.89A 5hieB-1f39A:
undetectable		 5hieB-1f39A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f75 UNDECAPRENYL
PYROPHOSPHATE
SYNTHETASE

(Micrococcus
luteus) 		PF01255
(Prenyltransf) 		4 ILE A 113
GLY A 114
LEU A 100
PHE A  95
 None
 0.77A 5hieB-1f75A:
undetectable		 5hieB-1f75A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gng GLYCOGEN SYNTHASE
KINASE-3 BETA

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A  62
GLY A  63
LEU A 112
ASP A 200
PHE A 201
 None
 1.12A 5hieB-1gngA:
20.9		 5hieB-1gngA:
29.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gqj ALPHA-D-GLUCURONIDAS
E

(Cellvibrio
japonicus) 		PF03648
(Glyco_hydro_67N)
PF07477
(Glyco_hydro_67C)
PF07488
(Glyco_hydro_67M) 		4 ILE A 237
GLY A 236
LEU A 315
PHE A 285
 None
 0.80A 5hieB-1gqjA:
undetectable		 5hieB-1gqjA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hl2 N-ACETYLNEURAMINATE
LYASE SUBUNIT

(Escherichia
coli) 		PF00701
(DHDPS) 		4 ILE A 206
GLY A 205
PHE A  33
ASP A  40
 3PY  A 802 ( 4.9A)
None
None
None
 0.73A 5hieB-1hl2A:
undetectable		 5hieB-1hl2A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0n XANTHAN LYASE

(Bacillus sp.
GL1) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		4 ILE A 325
GLY A 324
LEU A 224
PHE A 228
 None
 0.85A 5hieB-1j0nA:
undetectable		 5hieB-1j0nA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jik TYROSYL-TRNA
SYNTHETASE

(Staphylococcus
aureus) 		PF00579
(tRNA-synt_1b) 		5 ILE A 200
GLY A 198
LEU A 128
CYH A  37
ASP A  80
 None
None
None
545  A 421 ( 4.2A)
545  A 421 (-3.4A)
 1.31A 5hieB-1jikA:
undetectable		 5hieB-1jikA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k3s SIGE

(Salmonella
enterica) 		PF07824
(Chaperone_III) 		4 ILE A  70
GLY A  71
LEU A  23
PHE A  33
 None
 0.72A 5hieB-1k3sA:
undetectable		 5hieB-1k3sA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k8q TRIACYLGLYCEROL
LIPASE, GASTRIC

(Canis lupus) 		PF00561
(Abhydrolase_1) 		4 GLY A 321
LEU A 309
PHE A 284
ASP A 333
 None
 0.86A 5hieB-1k8qA:
undetectable		 5hieB-1k8qA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kwc 2,3-DIHYDROXYBIPHENY
L DIOXYGENASE

(Pseudomonas sp.
KKS102) 		PF00903
(Glyoxalase) 		4 ILE B 143
GLY B 142
LEU B 198
PHE B 186
 None
None
None
BPY  B 401 (-4.4A)
 0.60A 5hieB-1kwcB:
undetectable		 5hieB-1kwcB:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l9w 3-DEHYDROQUINATE
DEHYDRATASE AROD

(Salmonella
enterica) 		PF01487
(DHquinase_I) 		4 ILE A  18
GLY A 226
LEU A 185
PHE A 219
 None
 0.85A 5hieB-1l9wA:
undetectable		 5hieB-1l9wA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ldn L-LACTATE
DEHYDROGENASE

(Geobacillus
stearothermophilus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 ILE A  51
GLY A  81
LEU A 263
CYH A  95
 None
 0.89A 5hieB-1ldnA:
undetectable		 5hieB-1ldnA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqq ALPHA-D-GLUCURONIDAS
E

(Geobacillus
stearothermophilus) 		PF03648
(Glyco_hydro_67N)
PF07477
(Glyco_hydro_67C)
PF07488
(Glyco_hydro_67M) 		4 ILE A 230
GLY A 229
LEU A 308
PHE A 278
 None
 0.88A 5hieB-1mqqA:
undetectable		 5hieB-1mqqA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1now BETA-HEXOSAMINIDASE
BETA CHAIN

(Homo sapiens) 		PF00728
(Glyco_hydro_20)
PF14845
(Glycohydro_20b2) 		4 ILE A 205
GLY A 204
LEU A  93
PHE A 140
 None
 0.90A 5hieB-1nowA:
undetectable		 5hieB-1nowA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s2j PEPTIDOGLYCAN
RECOGNITION PROTEIN
SA CG11709-PA

(Drosophila
melanogaster) 		PF01510
(Amidase_2) 		4 ILE A  85
GLY A  84
LEU A 141
ASP A 130
 None
 0.69A 5hieB-1s2jA:
undetectable		 5hieB-1s2jA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sgj CITRATE LYASE, BETA
SUBUNIT

(Deinococcus
radiodurans) 		PF03328
(HpcH_HpaI) 		4 ILE A  35
GLY A  16
ASP A  86
PHE A  83
 None
 0.84A 5hieB-1sgjA:
undetectable		 5hieB-1sgjA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1su7 CARBON MONOXIDE
DEHYDROGENASE 2

(Carboxydothermus
hydrogenoformans) 		PF03063
(Prismane) 		4 ILE A 293
GLY A 292
LEU A 100
CYH A 333
 None
None
None
NFS  A 639 (-2.2A)
 0.81A 5hieB-1su7A:
undetectable		 5hieB-1su7A:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxr PEPTIDOGLYCAN
RECOGNITION PROTEIN
SA CG11709-PA

(Drosophila
melanogaster) 		PF01510
(Amidase_2) 		4 ILE A  85
GLY A  84
LEU A 141
ASP A 130
 None
 0.85A 5hieB-1sxrA:
undetectable		 5hieB-1sxrA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uc4 DIOL DEHYDRASE ALPHA
SUBUNIT
DIOL DEHYDRASE BETA
SUBUNIT

(Klebsiella
oxytoca) 		PF02286
(Dehydratase_LU)
PF02288
(Dehydratase_MU) 		4 ILE B 205
GLY A 269
PHE B  71
PHE B 108
 None
 0.87A 5hieB-1uc4B:
undetectable		 5hieB-1uc4B:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vhx PUTATIVE HOLLIDAY
JUNCTION RESOLVASE

(Bacillus
subtilis) 		PF03652
(RuvX) 		4 ILE A  33
GLY A  41
LEU A  93
PHE A  61
 None
 0.77A 5hieB-1vhxA:
undetectable		 5hieB-1vhxA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xeu INTERNALIN C

(Listeria
monocytogenes) 		PF08191
(LRR_adjacent)
PF12354
(Internalin_N)
PF12799
(LRR_4) 		4 ILE A 137
GLY A 136
CYH A 141
ASP A 117
 None
 0.86A 5hieB-1xeuA:
undetectable		 5hieB-1xeuA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlp PETAL DEATH PROTEIN

(Dianthus
caryophyllus) 		PF13714
(PEP_mutase) 		4 ILE A 192
GLY A 191
LEU A 176
PHE A 134
 None
 0.82A 5hieB-1zlpA:
undetectable		 5hieB-1zlpA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLY A  20
LEU A  79
ASP A 161
PHE A 162
 None
 0.89A 5hieB-2a2aA:
23.2		 5hieB-2a2aA:
25.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ahw PUTATIVE ENZYME YDIF

(Escherichia
coli) 		PF01144
(CoA_trans) 		4 ILE A 311
GLY A 310
LEU A 447
PHE A 452
 COA  A2600 (-4.1A)
COA  A2600 (-3.1A)
None
None
 0.90A 5hieB-2ahwA:
undetectable		 5hieB-2ahwA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cjq RNA-DIRECTED RNA
POLYMERASE

(Pestivirus A) 		PF00998
(RdRP_3) 		4 ILE A 148
GLY A 147
LEU A 652
ASP A 634
 None
 0.80A 5hieB-2cjqA:
undetectable		 5hieB-2cjqA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ckf RING-HYDROXYLATING
DIOXYGENASE BETA
SUBUNIT

(Sphingomonas
sp. CHY-1) 		PF00866
(Ring_hydroxyl_B) 		4 ILE B 159
GLY B 139
LEU B  78
ASP B 142
 None
 0.89A 5hieB-2ckfB:
undetectable		 5hieB-2ckfB:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpy FLAGELLUM-SPECIFIC
ATP SYNTHASE

(Salmonella
enterica) 		PF00006
(ATP-synt_ab) 		4 GLY A 125
LEU A 224
PHE A 219
ASP A 129
 None
 0.79A 5hieB-2dpyA:
undetectable		 5hieB-2dpyA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e6m WERNER SYNDROME
ATP-DEPENDENT
HELICASE HOMOLOG

(Mus musculus) 		PF01612
(DNA_pol_A_exo1) 		4 GLY A 133
LEU A 118
PHE A 106
PHE A 145
 None
 0.77A 5hieB-2e6mA:
undetectable		 5hieB-2e6mA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eo5 419AA LONG
HYPOTHETICAL
AMINOTRANSFERASE

(Sulfurisphaera
tokodaii) 		PF00202
(Aminotran_3) 		4 ILE A  51
GLY A  50
LEU A 264
PHE A 265
 None
 0.68A 5hieB-2eo5A:
undetectable		 5hieB-2eo5A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9z CHEMOTAXIS PROTEIN
CHEC

(Thermotoga
maritima) 		PF04509
(CheC) 		4 ILE A  17
GLY A  18
LEU A 194
PHE A 198
 None
 0.90A 5hieB-2f9zA:
undetectable		 5hieB-2f9zA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fbv WERNER SYNDROME
HELICASE

(Homo sapiens) 		PF01612
(DNA_pol_A_exo1) 		4 GLY A 139
LEU A 124
PHE A 112
PHE A 151
 None
 0.64A 5hieB-2fbvA:
undetectable		 5hieB-2fbvA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fna CONSERVED
HYPOTHETICAL PROTEIN

(Sulfolobus
solfataricus) 		PF01637
(ATPase_2) 		5 ILE A  45
GLY A  41
LEU A 186
PHE A 200
ASP A 143
 None
ADP  A 500 (-3.3A)
None
EDO  A 502 (-4.8A)
MG  A 400 ( 3.9A)
 1.40A 5hieB-2fnaA:
undetectable		 5hieB-2fnaA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g1k SHIKIMATE KINASE

(Mycobacterium
tuberculosis) 		PF01202
(SKI) 		4 ILE A  18
GLY A  14
LEU A  69
ASP A  32
 None
SO4  A 501 (-3.1A)
None
None
 0.81A 5hieB-2g1kA:
undetectable		 5hieB-2g1kA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g5d GNA33

(Neisseria
gonorrhoeae) 		PF03562
(MltA)
PF06725
(3D) 		4 ILE A 246
GLY A 248
LEU A 321
PHE A 257
 None
 0.87A 5hieB-2g5dA:
undetectable		 5hieB-2g5dA:
23.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		5 ILE A  34
GLY A  35
CYH A 108
ASP A 169
PHE A 170
 STU  A 400 (-4.2A)
STU  A 400 (-3.3A)
STU  A 400 (-4.0A)
STU  A 400 (-3.6A)
None
 1.10A 5hieB-2gcdA:
24.6		 5hieB-2gcdA:
30.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk3 PUTATIVE CYTOPLASMIC
PROTEIN

(Salmonella
enterica) 		PF07090
(GATase1_like) 		4 ILE A  13
GLY A  14
LEU A 207
PHE A 209
 None
 0.90A 5hieB-2gk3A:
undetectable		 5hieB-2gk3A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h0r NICOTINAMIDASE

(Saccharomyces
cerevisiae) 		PF00857
(Isochorismatase) 		4 ILE A 199
LEU A  20
PHE A  13
ASP A 194
 None
 0.88A 5hieB-2h0rA:
undetectable		 5hieB-2h0rA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0e PROTEIN KINASE
C-BETA II

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		4 GLY A 351
LEU A 406
ASP A 484
PHE A 485
 None
None
PDS  A 901 (-3.6A)
None
 0.80A 5hieB-2i0eA:
10.8		 5hieB-2i0eA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i1j MOESIN

(Spodoptera
frugiperda) 		PF00373
(FERM_M)
PF00769
(ERM)
PF09379
(FERM_N)
PF09380
(FERM_C) 		4 ILE A  37
GLY A  38
LEU A 290
PHE A  84
 None
 0.84A 5hieB-2i1jA:
undetectable		 5hieB-2i1jA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iyo 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING

(Lactococcus
lactis) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		4 GLY A  62
LEU A 115
PHE A 122
ASP A  92
 None
 0.82A 5hieB-2iyoA:
undetectable		 5hieB-2iyoA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2olg PRO-PHENOLOXIDASE
ACTIVATING ENZYME-I

(Holotrichia
diomphalia) 		PF00089
(Trypsin) 		4 ILE A 236
GLY A 174
LEU A 168
ASP A 198
 None
 0.72A 5hieB-2olgA:
undetectable		 5hieB-2olgA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p2s PUTATIVE
OXIDOREDUCTASE

(Pectobacterium
atrosepticum) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 ILE A 175
GLY A 174
LEU A 188
PHE A 187
 None
EDO  A 341 ( 4.3A)
None
None
 0.73A 5hieB-2p2sA:
undetectable		 5hieB-2p2sA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p2w CITRATE SYNTHASE

(Thermotoga
maritima) 		PF00285
(Citrate_synt) 		5 ILE A 295
GLY A 249
LEU A 267
PHE A 277
ASP A 300
 None
FLC  A 402 ( 3.9A)
None
None
FLC  A 401 ( 3.0A)
 1.41A 5hieB-2p2wA:
undetectable		 5hieB-2p2wA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pg6 CYTOCHROME P450 2A6

(Homo sapiens) 		PF00067
(p450) 		4 GLY A 336
PHE A 452
ASP A 345
PHE A 343
 None
 0.88A 5hieB-2pg6A:
undetectable		 5hieB-2pg6A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pgw MUCONATE
CYCLOISOMERASE

(Sinorhizobium
meliloti) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ILE A 275
GLY A 276
CYH A 269
PHE A 301
 None
 0.84A 5hieB-2pgwA:
undetectable		 5hieB-2pgwA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pmo SER/THR PROTEIN
KINASE

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		4 ILE X 235
GLY X 234
PHE X 133
PHE X 142
 None
 0.88A 5hieB-2pmoX:
21.7		 5hieB-2pmoX:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyx TRYPTOPHAN
HALOGENASE

(Shewanella
frigidimarina) 		PF04820
(Trp_halogenase) 		4 ILE A  72
GLY A  73
PHE A 163
PHE A 522
 None
 0.86A 5hieB-2pyxA:
undetectable		 5hieB-2pyxA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q27 OXALYL-COA
DECARBOXYLASE

(Escherichia
coli) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 ILE A 431
GLY A 428
LEU A 526
CYH A 461
 None
 0.64A 5hieB-2q27A:
undetectable		 5hieB-2q27A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qr7 RIBOSOMAL PROTEIN S6
KINASE ALPHA-3

(Mus musculus) 		PF00069
(Pkinase) 		4 ILE A 428
GLY A 429
ASP A 561
PHE A 562
 None
 0.85A 5hieB-2qr7A:
19.7		 5hieB-2qr7A:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLY A  85
LEU A 139
ASP A 216
PHE A 217
 ANP  A1480 ( 3.8A)
None
ANP  A1480 (-3.5A)
None
 0.74A 5hieB-2v55A:
7.8		 5hieB-2v55A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vd5 DMPK PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLY A  80
LEU A 134
ASP A 213
PHE A 214
 None
None
BI8  A1417 (-3.8A)
None
 0.89A 5hieB-2vd5A:
21.1		 5hieB-2vd5A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vun ENAMIDASE

(Eubacterium
barkeri) 		PF01979
(Amidohydro_1) 		4 ILE A   9
GLY A  10
LEU A 289
ASP A 337
 None
 0.89A 5hieB-2vunA:
undetectable		 5hieB-2vunA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w49 TROPONIN C, SKELETAL
MUSCLE

(Gallus gallus) 		PF13499
(EF-hand_7)
PF13833
(EF-hand_8) 		4 GLY 0 118
PHE 0 150
ASP 0 113
PHE 0 111
 None
None
CA  01001 ( 4.3A)
None
 0.87A 5hieB-2w490:
undetectable		 5hieB-2w490:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wuq BETA-LACTAMASE
REGULATORY PROTEIN
BLAB

(Streptomyces
cacaoi) 		PF13354
(Beta-lactamase2) 		4 ILE A  37
GLY A  36
LEU A 138
ASP A  40
 None
 0.84A 5hieB-2wuqA:
undetectable		 5hieB-2wuqA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1

(Gracilariopsis
lemaneiformis) 		PF01055
(Glyco_hydro_31) 		4 GLY A 371
LEU A 511
PHE A 463
ASP A 414
 None
 0.91A 5hieB-2x2iA:
undetectable		 5hieB-2x2iA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xu2 UPF0271 PROTEIN
PA4511

(Pseudomonas
aeruginosa) 		PF03746
(LamB_YcsF) 		4 ILE A  65
GLY A  66
PHE A  19
ASP A  14
 None
None
None
CIT  A1249 (-2.9A)
 0.82A 5hieB-2xu2A:
undetectable		 5hieB-2xu2A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z9s PEROXIREDOXIN-1

(Rattus
norvegicus) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		4 ILE A   8
GLY A   9
PHE A 165
ASP A 134
 None
 0.82A 5hieB-2z9sA:
undetectable		 5hieB-2z9sA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z9s PEROXIREDOXIN-1

(Rattus
norvegicus) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		4 ILE A 125
GLY A 124
ASP A 107
PHE A  15
 None
 0.86A 5hieB-2z9sA:
undetectable		 5hieB-2z9sA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLY A  98
LEU A 158
ASP A 236
PHE A 237
 STU  A 400 (-3.6A)
None
STU  A 400 ( 3.8A)
None
 0.88A 5hieB-3a62A:
22.9		 5hieB-3a62A:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ber PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX47

(Homo sapiens) 		PF00270
(DEAD) 		4 ILE A 130
GLY A 128
LEU A 165
ASP A 155
 None
PO4  A 350 (-3.9A)
None
PO4  A 350 ( 3.1A)
 0.75A 5hieB-3berA:
undetectable		 5hieB-3berA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqr DEATH-ASSOCIATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLY A  22
LEU A  79
ASP A 161
PHE A 162
 None
PGO  A 501 ( 4.6A)
GOL  A 503 ( 3.1A)
None
 0.82A 5hieB-3bqrA:
21.5		 5hieB-3bqrA:
26.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dmp URACIL
PHOSPHORIBOSYLTRANSF
ERASE

(Burkholderia
pseudomallei) 		PF14681
(UPRTase) 		4 GLY A 205
LEU A 185
PHE A 176
ASP A 191
 None
 0.67A 5hieB-3dmpA:
undetectable		 5hieB-3dmpA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e4e CYTOCHROME P450 2E1

(Homo sapiens) 		PF00067
(p450) 		4 ILE A 289
GLY A 288
LEU A 199
ASP A 295
 None
 0.73A 5hieB-3e4eA:
undetectable		 5hieB-3e4eA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		4 GLY A  16
LEU A  65
ASP A 185
PHE A 186
 DRK  A 384 ( 4.4A)
None
DRK  A 384 ( 4.7A)
None
 0.82A 5hieB-3eb0A:
6.6		 5hieB-3eb0A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLY A  45
LEU A 106
ASP A 186
PHE A 187
 985  A   1 ( 3.9A)
None
985  A   1 ( 4.0A)
None
 0.85A 5hieB-3f2aA:
22.3		 5hieB-3f2aA:
25.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN

(Geobacillus
kaustophilus) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		4 GLY A1183
PHE A1231
CYH A1264
ASP A1215
 None
 0.77A 5hieB-3f2bA:
undetectable		 5hieB-3f2bA:
13.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f3z CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		4 GLY A  37
CYH A 105
ASP A 169
PHE A 170
 None
DRK  A   1 (-4.1A)
None
None
 0.84A 5hieB-3f3zA:
23.1		 5hieB-3f3zA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdb PUTATIVE
PLP-DEPENDENT
BETA-CYSTATHIONASE

(Corynebacterium
diphtheriae) 		PF00155
(Aminotran_1_2) 		4 ILE A 320
GLY A 322
ASP A 338
PHE A 342
 EDO  A 388 (-4.7A)
EDO  A 388 (-4.2A)
EDO  A 390 ( 4.5A)
None
 0.87A 5hieB-3fdbA:
undetectable		 5hieB-3fdbA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fq4 INTEGRIN BETA-4

(Homo sapiens) 		PF03160
(Calx-beta) 		4 GLY A1051
LEU A1083
PHE A 994
ASP A 990
 None
 0.90A 5hieB-3fq4A:
undetectable		 5hieB-3fq4A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h11 CASP8 AND FADD-LIKE
APOPTOSIS REGULATOR

(Homo sapiens) 		PF00656
(Peptidase_C14) 		4 ILE A 260
GLY A 261
PHE A 355
PHE A 271
 None
 0.86A 5hieB-3h11A:
undetectable		 5hieB-3h11A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hko CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 2
CALMODULIN-LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		4 GLY A  19
CYH A  92
ASP A 195
PHE A 196
 ANP  A 329 (-3.3A)
ANP  A 329 (-4.1A)
MG  A 330 ( 2.9A)
None
 0.76A 5hieB-3hkoA:
21.0		 5hieB-3hkoA:
26.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ih5 ELECTRON TRANSFER
FLAVOPROTEIN
ALPHA-SUBUNIT

(Bacteroides
thetaiotaomicron) 		PF01012
(ETF) 		4 ILE A  99
GLY A 100
LEU A  36
PHE A   4
 None
 0.84A 5hieB-3ih5A:
undetectable		 5hieB-3ih5A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3is5 CALCIUM-DEPENDENT
PROTEIN KINASE

(Toxoplasma
gondii) 		PF00069
(Pkinase) 		4 GLY A 142
CYH A 213
ASP A 281
PHE A 282
 ANP  A   1 (-3.5A)
ANP  A   1 (-4.3A)
MG  A 399 ( 3.0A)
GOL  A 398 (-4.5A)
 0.89A 5hieB-3is5A:
25.0		 5hieB-3is5A:
29.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3js3 3-DEHYDROQUINATE
DEHYDRATASE

(Clostridioides
difficile) 		PF01487
(DHquinase_I) 		4 ILE A  19
GLY A 227
LEU A 186
PHE A 220
 None
 0.88A 5hieB-3js3A:
undetectable		 5hieB-3js3A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3maj DNA PROCESSING CHAIN
A

(Rhodopseudomonas
palustris) 		PF02481
(DNA_processg_A) 		4 GLY A 248
LEU A 147
PHE A 143
ASP A 167
 None
 0.71A 5hieB-3majA:
undetectable		 5hieB-3majA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mi9 CELL DIVISION
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A  25
CYH A 106
ASP A 167
PHE A 168
 None
 0.83A 5hieB-3mi9A:
6.9		 5hieB-3mi9A:
24.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ILE A 355
GLY A 356
CYH A 424
ASP A 486
PHE A 487
 SM5  A   1 (-4.3A)
SM5  A   1 ( 4.9A)
SM5  A   1 ( 4.4A)
SM5  A   1 (-3.5A)
None
 1.10A 5hieB-3omvA:
34.8		 5hieB-3omvA:
77.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ILE A 355
GLY A 356
LEU A 397
PHE A 408
 SM5  A   1 (-4.3A)
SM5  A   1 ( 4.9A)
None
None
 0.87A 5hieB-3omvA:
34.8		 5hieB-3omvA:
77.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ILE A 355
GLY A 356
PHE A 408
CYH A 424
 SM5  A   1 (-4.3A)
SM5  A   1 ( 4.9A)
None
SM5  A   1 ( 4.4A)
 0.50A 5hieB-3omvA:
34.8		 5hieB-3omvA:
77.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opy 6-PHOSPHOFRUCTO-1-KI
NASE BETA-SUBUNIT

(Komagataella
pastoris) 		PF00365
(PFK) 		4 ILE B 844
GLY B 843
CYH B 353
ASP B 849
 None
 0.85A 5hieB-3opyB:
undetectable		 5hieB-3opyB:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pbk FATTY ACYL-ADENYLATE
LIGASE

(Escherichia
coli) 		PF00501
(AMP-binding) 		4 ILE A 213
GLY A 212
LEU A  23
PHE A  20
 1ZZ  A   1 ( 4.8A)
None
None
None
 0.78A 5hieB-3pbkA:
undetectable		 5hieB-3pbkA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdx TYROSINE
AMINOTRANSFERASE

(Mus musculus) 		PF00155
(Aminotran_1_2) 		4 ILE A 305
GLY A 302
CYH A 151
ASP A 137
 None
 0.87A 5hieB-3pdxA:
undetectable		 5hieB-3pdxA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q46 TT-IPPASE

(Thermococcus
thioreducens) 		PF00719
(Pyrophosphatase) 		4 ILE A  93
GLY A 154
PHE A 116
ASP A 121
 None
 0.90A 5hieB-3q46A:
undetectable		 5hieB-3q46A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfv CDC42BPB PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A  82
GLY A  83
LEU A 139
ASP A 218
PHE A 219
 None
NM7  A 416 (-3.0A)
None
EDO  A 417 (-3.7A)
None
 1.18A 5hieB-3qfvA:
7.4		 5hieB-3qfvA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qnw CASPASE-6

(Homo sapiens) 		PF00656
(Peptidase_C14) 		4 ILE A  46
GLY A  45
LEU B 232
CYH A  87
 None
 0.57A 5hieB-3qnwA:
undetectable		 5hieB-3qnwA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r8e HYPOTHETICAL SUGAR
KINASE

(Cytophaga
hutchinsonii) 		PF00480
(ROK) 		4 ILE A  38
GLY A  39
LEU A   3
PHE A  51
 None
 0.68A 5hieB-3r8eA:
undetectable		 5hieB-3r8eA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3riq TAILSPIKE PROTEIN

(Salmonella
virus 9NA) 		PF09251
(PhageP22-tail) 		4 ILE A 385
GLY A 386
LEU A 428
ASP A 424
 None
 0.85A 5hieB-3riqA:
undetectable		 5hieB-3riqA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rqz METALLOPHOSPHOESTERA
SE

(Sphaerobacter
thermophilus) 		PF12850
(Metallophos_2) 		4 GLY A  60
LEU A 235
CYH A  45
ASP A   8
 None
None
None
ZN  A 301 ( 3.1A)
 0.81A 5hieB-3rqzA:
undetectable		 5hieB-3rqzA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swg UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Aquifex
aeolicus) 		PF00275
(EPSP_synthase) 		4 ILE A 276
GLY A 277
LEU A 415
ASP A 253
 None
 0.77A 5hieB-3swgA:
undetectable		 5hieB-3swgA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txo PROTEIN KINASE C ETA
TYPE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		4 GLY A 364
LEU A 419
ASP A 497
PHE A 498
 None
None
07U  A   1 (-3.6A)
None
 0.89A 5hieB-3txoA:
5.6		 5hieB-3txoA:
26.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vpj TSE1-SPECIFIC
IMMUNITY PROTEIN

(Pseudomonas
aeruginosa) 		no annotation 4 ILE E 158
GLY E 144
LEU E 102
PHE E  24
 None
 0.91A 5hieB-3vpjE:
undetectable		 5hieB-3vpjE:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vpz GLUCOKINASE

(Pseudoalteromonas
sp. AS-131) 		PF02685
(Glucokinase) 		4 ILE A  16
GLY A  17
CYH A  72
ASP A 112
 None
 0.73A 5hieB-3vpzA:
undetectable		 5hieB-3vpzA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wrc GALLATE DIOXYGENASE

(Sphingomonas
paucimobilis) 		PF02900
(LigB)
PF07746
(LigA) 		4 ILE A   5
GLY A   6
LEU A  72
CYH A 142
 None
 0.89A 5hieB-3wrcA:
undetectable		 5hieB-3wrcA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13

(Mycobacterium
tuberculosis) 		PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N) 		4 ILE A 570
GLY A 492
LEU A  24
ASP A 564
 None
 0.82A 5hieB-3zukA:
undetectable		 5hieB-3zukA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agu CYCLIN-DEPENDENT
KINASE-LIKE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A  10
GLY A  11
CYH A  83
PHE A 145
 D15  A 500 (-4.2A)
D15  A 500 (-3.8A)
D15  A 500 (-4.3A)
None
 0.81A 5hieB-4aguA:
23.6		 5hieB-4aguA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aoa BETA-PHENYLALANINE
AMINOTRANSFERASE

(Variovorax
paradoxus) 		PF00202
(Aminotran_3) 		4 ILE A 269
GLY A 270
PHE A 288
CYH A 117
 None
 0.89A 5hieB-4aoaA:
undetectable		 5hieB-4aoaA:
22.32