SIMILAR PATTERNS OF AMINO ACIDS FOR 5HIE_A_P06A801_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ahi 7
ALPHA-HYDROXYSTEROID
DEHYDROGENASE

(Escherichia
coli) 		PF13561
(adh_short_C2) 		4 ILE A  27
GLY A  24
PHE A  81
PHE A  63
 None
 1.06A 5hieA-1ahiA:
undetectable		 5hieA-1ahiA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dll TETANUS TOXIN

(Clostridium
tetani) 		PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N) 		4 ILE A 918
GLY A 917
ASP A1116
PHE A1305
 None
 1.12A 5hieA-1dllA:
undetectable		 5hieA-1dllA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f80 HOLO-(ACYL CARRIER
PROTEIN) SYNTHASE

(Bacillus
subtilis) 		PF01648
(ACPS) 		4 ILE A 103
GLY A  52
PHE A  64
ASP A   8
 None
 0.98A 5hieA-1f80A:
undetectable		 5hieA-1f80A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hl2 N-ACETYLNEURAMINATE
LYASE SUBUNIT

(Escherichia
coli) 		PF00701
(DHDPS) 		4 ILE A 206
GLY A 205
PHE A  33
ASP A  40
 3PY  A 802 ( 4.9A)
None
None
None
 0.73A 5hieA-1hl2A:
undetectable		 5hieA-1hl2A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jc2 TROPONIN C, SKELETAL
MUSCLE

(Gallus gallus) 		PF13499
(EF-hand_7) 		4 ILE A 134
GLY A 119
PHE A 102
PHE A 112
 None
 1.12A 5hieA-1jc2A:
undetectable		 5hieA-1jc2A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pox PYRUVATE OXIDASE

(Lactobacillus
plantarum) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 ILE A 426
GLY A 425
PHE A 526
PHE A 514
 None
 1.06A 5hieA-1poxA:
0.0		 5hieA-1poxA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1px8 BETA-XYLOSIDASE

(Thermoanaerobacterium
saccharolyticum) 		PF01229
(Glyco_hydro_39) 		4 ILE A 142
GLY A 146
PHE A  97
PHE A  89
 None
 0.94A 5hieA-1px8A:
undetectable		 5hieA-1px8A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6m ACETYLTRANSFERASE,
GNAT FAMILY

(Enterococcus
faecalis) 		PF00583
(Acetyltransf_1) 		4 ILE A 129
GLY A 128
PHE A 169
ASP A 135
 None
SO4  A1003 ( 4.3A)
None
None
 0.57A 5hieA-1u6mA:
undetectable		 5hieA-1u6mA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1us7 HSP90 CO-CHAPERONE
CDC37

(Homo sapiens) 		PF08564
(CDC37_C)
PF08565
(CDC37_M) 		4 ILE B 159
PHE B 237
CYH B 194
PHE B 218
 None
 1.10A 5hieA-1us7B:
undetectable		 5hieA-1us7B:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1us8 DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE

(Pyrococcus
furiosus) 		PF13476
(AAA_23)
no annotation 		4 ILE A 143
GLY A 141
PHE A 132
ASP B 822
 None
 1.13A 5hieA-1us8A:
undetectable		 5hieA-1us8A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xq1 PUTATIVE TROPINONE
REDUCATSE

(Arabidopsis
thaliana) 		PF13561
(adh_short_C2) 		4 ILE A  26
GLY A  27
PHE A  37
PHE A 235
 None
 1.12A 5hieA-1xq1A:
undetectable		 5hieA-1xq1A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yq3 SUCCINATE
DEHYDROGENASE IP
SUBUNIT

(Gallus gallus) 		PF13085
(Fer2_3)
PF13534
(Fer4_17) 		4 ILE B  77
GLY B  80
PHE B 118
CYH B  85
 None
None
None
FES  B1002 (-2.2A)
 0.82A 5hieA-1yq3B:
undetectable		 5hieA-1yq3B:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a1r POLY(A)-SPECIFIC
RIBONUCLEASE PARN

(Homo sapiens) 		PF01424
(R3H)
PF04857
(CAF1) 		4 ILE A  34
GLY A  33
PHE A 300
PHE A  69
 A  C 502 ( 4.1A)
A  C 503 ( 3.8A)
None
None
 1.09A 5hieA-2a1rA:
undetectable		 5hieA-2a1rA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bx7 DIHYDROOROTATE
DEHYDROGENASE

(Lactococcus
lactis) 		PF01180
(DHO_dh) 		4 ILE A 224
GLY A 221
PHE A  15
ASP A 256
 FMN  A1312 ( 4.9A)
FMN  A1312 (-3.6A)
None
None
 1.01A 5hieA-2bx7A:
undetectable		 5hieA-2bx7A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e18 NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Pyrococcus
horikoshii) 		PF02540
(NAD_synthase) 		4 ILE A 195
GLY A 194
PHE A 135
ASP A 189
 None
 1.13A 5hieA-2e18A:
undetectable		 5hieA-2e18A:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2efj 3,7-DIMETHYLXANTHINE
METHYLTRANSFERASE

(Coffea
canephora) 		PF03492
(Methyltransf_7) 		4 ILE A  74
PHE A 292
PHE A 225
PHE A  27
 None
None
None
37T  A 502 (-4.6A)
 1.11A 5hieA-2efjA:
undetectable		 5hieA-2efjA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hi9 PLASMA SERINE
PROTEASE INHIBITOR

(Homo sapiens) 		PF00079
(Serpin) 		4 ILE A 304
GLY A 303
ASP A  32
PHE A  31
 None
 1.13A 5hieA-2hi9A:
undetectable		 5hieA-2hi9A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2htv NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 ILE A 106
GLY A 105
PHE A 446
PHE A 374
 None
 0.65A 5hieA-2htvA:
undetectable		 5hieA-2htvA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iou MAJOR TROPISM
DETERMINANT P1

(Bordetella
virus BPP1) 		no annotation 4 ILE A 212
GLY A 197
PHE A 341
ASP A 192
 None
 1.01A 5hieA-2iouA:
undetectable		 5hieA-2iouA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iv0 ISOCITRATE
DEHYDROGENASE

(Archaeoglobus
fulgidus) 		PF00180
(Iso_dh) 		4 ILE A 159
GLY A 158
PHE A 197
ASP A 154
 None
 1.01A 5hieA-2iv0A:
undetectable		 5hieA-2iv0A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1v ENDOPLASMIN

(Canis lupus) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		4 ILE A 492
GLY A 489
ASP A 573
PHE A 540
 None
 0.98A 5hieA-2o1vA:
undetectable		 5hieA-2o1vA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oe1 THIOREDOXIN-3

(Saccharomyces
cerevisiae) 		PF00085
(Thioredoxin) 		4 ILE A  90
GLY A  91
CYH A  69
ASP A  26
 None
None
SO4  A1002 ( 4.8A)
None
 0.92A 5hieA-2oe1A:
undetectable		 5hieA-2oe1A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pg6 CYTOCHROME P450 2A6

(Homo sapiens) 		PF00067
(p450) 		4 GLY A 336
PHE A 452
ASP A 345
PHE A 343
 None
 0.85A 5hieA-2pg6A:
undetectable		 5hieA-2pg6A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pgw MUCONATE
CYCLOISOMERASE

(Sinorhizobium
meliloti) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ILE A 275
GLY A 276
CYH A 269
PHE A 301
 None
 0.84A 5hieA-2pgwA:
undetectable		 5hieA-2pgwA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyx TRYPTOPHAN
HALOGENASE

(Shewanella
frigidimarina) 		PF04820
(Trp_halogenase) 		4 ILE A  72
GLY A  73
PHE A 163
PHE A 522
 None
 0.86A 5hieA-2pyxA:
undetectable		 5hieA-2pyxA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qsr TRANSCRIPTION-REPAIR
COUPLING FACTOR

(Streptococcus
pneumoniae) 		PF03461
(TRCF) 		4 ILE A1043
GLY A1074
ASP A1081
PHE A1084
 None
 0.95A 5hieA-2qsrA:
undetectable		 5hieA-2qsrA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyz UNCHARACTERIZED
PROTEIN

(Clostridium
tetani) 		PF09643
(YopX) 		4 ILE A  71
GLY A 120
CYH A  95
ASP A  60
 None
 0.94A 5hieA-2qyzA:
undetectable		 5hieA-2qyzA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v6g PROGESTERONE
5-BETA-REDUCTASE

(Digitalis
lanata) 		PF01370
(Epimerase) 		4 ILE A 340
GLY A 339
PHE A 287
PHE A 237
 None
 1.12A 5hieA-2v6gA:
undetectable		 5hieA-2v6gA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2veo LIPASE A

(Moesziomyces
antarcticus) 		PF03583
(LIP) 		4 ILE A 404
GLY A 403
PHE A 358
PHE A 380
 None
 1.03A 5hieA-2veoA:
undetectable		 5hieA-2veoA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vr5 GLYCOGEN OPERON
PROTEIN GLGX

(Sulfolobus
solfataricus) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		4 ILE A 284
GLY A 359
PHE A 227
PHE A 249
 None
 1.13A 5hieA-2vr5A:
undetectable		 5hieA-2vr5A:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w49 TROPONIN C, SKELETAL
MUSCLE

(Gallus gallus) 		PF13499
(EF-hand_7)
PF13833
(EF-hand_8) 		4 GLY 0 118
PHE 0 150
ASP 0 113
PHE 0 111
 None
None
CA  01001 ( 4.3A)
None
 0.88A 5hieA-2w490:
undetectable		 5hieA-2w490:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfu CARBOHYDRATE BINDING
FAMILY 6

(Ruminiclostridium
thermocellum) 		no annotation 4 ILE A  94
GLY A  74
PHE A  85
PHE A 114
 None
 1.11A 5hieA-2yfuA:
undetectable		 5hieA-2yfuA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2za1 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Plasmodium
falciparum) 		PF00215
(OMPdecase) 		4 ILE A 296
GLY A 293
PHE A  88
ASP A  28
 None
OMP  A 500 (-3.6A)
None
None
 1.01A 5hieA-2za1A:
undetectable		 5hieA-2za1A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3n DIHYDROOROTATE
DEHYDROGENASE

(Trypanosoma
cruzi) 		PF01180
(DHO_dh) 		4 ILE A 227
GLY A 224
PHE A  17
ASP A 258
 ILE  A 227 (-0.4A)
GLY  A 224 (-0.0A)
PHE  A  17 ( 1.3A)
ASP  A 258 ( 0.5A)
 0.98A 5hieA-3c3nA:
undetectable		 5hieA-3c3nA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cq5 HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Corynebacterium
glutamicum) 		PF00155
(Aminotran_1_2) 		4 ILE A 362
GLY A 299
PHE A 311
ASP A 314
 None
 1.01A 5hieA-3cq5A:
undetectable		 5hieA-3cq5A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d45 POLY(A)-SPECIFIC
RIBONUCLEASE PARN

(Mus musculus) 		PF01424
(R3H)
PF04857
(CAF1)
PF08675
(RNA_bind) 		4 ILE A  34
GLY A  33
PHE A 293
PHE A  69
 GDP  A 652 ( 4.4A)
None
None
None
 1.14A 5hieA-3d45A:
undetectable		 5hieA-3d45A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkh LACCASE-1

(Melanocarpus
albomyces) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 ILE A 419
CYH A 503
ASP A 422
PHE A 427
 None
CU  A 601 (-2.1A)
None
None
 1.04A 5hieA-3dkhA:
undetectable		 5hieA-3dkhA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e18 OXIDOREDUCTASE

(Listeria
innocua) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 GLY A 159
PHE A 210
ASP A 204
PHE A 200
 None
 1.04A 5hieA-3e18A:
undetectable		 5hieA-3e18A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN

(Geobacillus
kaustophilus) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		4 GLY A1183
PHE A1231
CYH A1264
ASP A1215
 None
 0.75A 5hieA-3f2bA:
undetectable		 5hieA-3f2bA:
13.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h11 CASP8 AND FADD-LIKE
APOPTOSIS REGULATOR

(Homo sapiens) 		PF00656
(Peptidase_C14) 		4 ILE A 260
GLY A 261
PHE A 355
PHE A 271
 None
 0.88A 5hieA-3h11A:
undetectable		 5hieA-3h11A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4i UNCHARACTERIZED
PROTEIN

(Pseudomonas
syringae group
genomosp. 3) 		PF03737
(RraA-like) 		4 ILE A 163
GLY A 162
CYH A 178
ASP A 119
 None
 1.03A 5hieA-3k4iA:
undetectable		 5hieA-3k4iA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6u ABC-TYPE SUGAR
TRANSPORT SYSTEM
PERIPLASMIC
COMPONENT

(Exiguobacterium
sibiricum) 		PF13407
(Peripla_BP_4) 		4 GLY A  89
PHE A 258
PHE A  13
ASP A  66
 None
 0.78A 5hieA-3l6uA:
undetectable		 5hieA-3l6uA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l76 ASPARTOKINASE

(Synechocystis
sp. PCC 6803) 		PF00696
(AA_kinase)
PF01842
(ACT)
PF13840
(ACT_7) 		4 ILE A 366
GLY A 364
PHE A 376
PHE A 495
 None
 0.90A 5hieA-3l76A:
undetectable		 5hieA-3l76A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m8l CAPSID PROTEIN

(Feline
calicivirus) 		PF00915
(Calici_coat) 		4 ILE A 550
GLY A 382
PHE A 566
ASP A 422
 None
 1.12A 5hieA-3m8lA:
undetectable		 5hieA-3m8lA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mi9 CELL DIVISION
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A  25
CYH A 106
ASP A 167
PHE A 168
 None
 0.83A 5hieA-3mi9A:
22.7		 5hieA-3mi9A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mkr COATOMER SUBUNIT
ALPHA

(Bos taurus) 		PF06957
(COPI_C) 		4 ILE B 919
GLY B 995
PHE B1223
ASP B 929
 None
 0.91A 5hieA-3mkrB:
undetectable		 5hieA-3mkrB:
20.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ILE A 355
CYH A 424
ASP A 486
PHE A 487
 SM5  A   1 (-4.3A)
SM5  A   1 ( 4.4A)
SM5  A   1 (-3.5A)
None
 0.91A 5hieA-3omvA:
34.7		 5hieA-3omvA:
77.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ILE A 355
GLY A 356
PHE A 408
CYH A 424
 SM5  A   1 (-4.3A)
SM5  A   1 ( 4.9A)
None
SM5  A   1 ( 4.4A)
 0.51A 5hieA-3omvA:
34.7		 5hieA-3omvA:
77.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opy 6-PHOSPHOFRUCTO-1-KI
NASE BETA-SUBUNIT

(Komagataella
pastoris) 		PF00365
(PFK) 		4 ILE B 844
GLY B 843
CYH B 353
ASP B 849
 None
 0.85A 5hieA-3opyB:
undetectable		 5hieA-3opyB:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q46 TT-IPPASE

(Thermococcus
thioreducens) 		PF00719
(Pyrophosphatase) 		4 ILE A  93
GLY A 154
PHE A 116
ASP A 121
 None
 0.89A 5hieA-3q46A:
undetectable		 5hieA-3q46A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qw3 OROTIDINE-5-PHOSPHAT
E
DECARBOXYLASE/OROTAT
E
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE
(OMPDCASE-OPRTASE,
PUTATIVE)

(Leishmania
infantum) 		PF00215
(OMPdecase) 		4 ILE A  77
GLY A  76
PHE A 100
CYH A  17
 None
 0.87A 5hieA-3qw3A:
undetectable		 5hieA-3qw3A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qw4 UMP SYNTHASE

(Leishmania
donovani) 		PF00156
(Pribosyltran)
PF00215
(OMPdecase) 		4 ILE B  77
GLY B  76
PHE B 100
CYH B  17
 None
 0.88A 5hieA-3qw4B:
undetectable		 5hieA-3qw4B:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sp1 CYSTEINYL-TRNA
SYNTHETASE

(Borreliella
burgdorferi) 		PF01406
(tRNA-synt_1e) 		4 ILE A  69
GLY A  70
CYH A 221
PHE A 105
 None
None
ZN  A 481 (-2.2A)
None
 1.13A 5hieA-3sp1A:
undetectable		 5hieA-3sp1A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t57 UDP-N-ACETYLGLUCOSAM
INE
O-ACYLTRANSFERASE
DOMAIN-CONTAINING
PROTEIN

(Arabidopsis
thaliana) 		PF00132
(Hexapep)
PF13720
(Acetyltransf_11) 		4 ILE A  65
GLY A  66
CYH A  75
PHE A 110
 None
 0.95A 5hieA-3t57A:
undetectable		 5hieA-3t57A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5o COMPLEMENT COMPONENT
C6

(Homo sapiens) 		PF00057
(Ldl_recept_a)
PF00084
(Sushi)
PF00090
(TSP_1)
PF01823
(MACPF) 		4 ILE A 282
PHE A 233
PHE A 360
ASP A 236
 None
 0.89A 5hieA-3t5oA:
undetectable		 5hieA-3t5oA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3td9 BRANCHED CHAIN AMINO
ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN

(Thermotoga
maritima) 		PF13458
(Peripla_BP_6) 		4 ILE A 249
GLY A 356
ASP A 359
PHE A 360
 EDO  A 407 (-4.6A)
None
None
None
 1.11A 5hieA-3td9A:
undetectable		 5hieA-3td9A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ti8 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 ILE A 106
GLY A 105
PHE A 446
PHE A 374
 None
 0.60A 5hieA-3ti8A:
undetectable		 5hieA-3ti8A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vpz GLUCOKINASE

(Pseudoalteromonas
sp. AS-131) 		PF02685
(Glucokinase) 		4 GLY A 171
PHE A 289
CYH A 155
PHE A 293
 None
 1.13A 5hieA-3vpzA:
undetectable		 5hieA-3vpzA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w3e COTYLEDONEOUS
YIELDIN-LIKE PROTEIN

(Vigna
unguiculata) 		PF00182
(Glyco_hydro_19) 		4 ILE A   7
GLY A   8
PHE A  29
ASP A  13
 None
 1.13A 5hieA-3w3eA:
undetectable		 5hieA-3w3eA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agu CYCLIN-DEPENDENT
KINASE-LIKE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A  10
GLY A  11
CYH A  83
PHE A 145
 D15  A 500 (-4.2A)
D15  A 500 (-3.8A)
D15  A 500 (-4.3A)
None
 0.79A 5hieA-4aguA:
23.8		 5hieA-4aguA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4btm TAU-TUBULIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A  64
GLY A  65
PHE A 117
PHE A 201
 F8E  A1340 (-4.8A)
F8E  A1340 ( 4.3A)
None
None
 0.82A 5hieA-4btmA:
4.0		 5hieA-4btmA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c22 L-FUCOSE ISOMERASE

(Streptococcus
pneumoniae) 		PF02952
(Fucose_iso_C)
PF07881
(Fucose_iso_N1)
PF07882
(Fucose_iso_N2) 		4 ILE A 189
GLY A 186
PHE A 332
PHE A 297
 None
 0.68A 5hieA-4c22A:
undetectable		 5hieA-4c22A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ep6 CYTOCHROME P450-LIKE
PROTEIN XPLA

(Rhodococcus
rhodochrous) 		PF00067
(p450) 		4 ILE A 396
GLY A 397
PHE A 540
PHE A 441
 HEM  A 601 (-3.9A)
None
None
HEM  A 601 (-4.4A)
 1.01A 5hieA-4ep6A:
undetectable		 5hieA-4ep6A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fem OUTER MEMBRANE
PROTEIN SUSE

(Bacteroides
thetaiotaomicron) 		PF16411
(SusF_SusE) 		4 ILE A 347
GLY A 382
PHE A 214
PHE A 263
 None
 1.14A 5hieA-4femA:
undetectable		 5hieA-4femA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iop C-TYPE LECTIN DOMAIN
FAMILY 2 MEMBER A

(Homo sapiens) 		PF00059
(Lectin_C) 		4 ILE A 161
GLY A 159
PHE A  72
PHE A  85
 None
 0.88A 5hieA-4iopA:
undetectable		 5hieA-4iopA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3j HEPATOCYTE GROWTH
FACTOR BETA CHAIN

(Homo sapiens) 		PF01403
(Sema)
PF01437
(PSI) 		4 ILE B  56
PHE B 261
PHE B 253
PHE B 196
 None
 1.02A 5hieA-4k3jB:
undetectable		 5hieA-4k3jB:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mdp BETA-GLUCOSIDASE

(Humicola grisea) 		PF00232
(Glyco_hydro_1) 		4 GLY A  28
PHE A 134
CYH A  36
ASP A 122
 None
 1.08A 5hieA-4mdpA:
undetectable		 5hieA-4mdpA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nfn TAU-TUBULIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLY A  41
PHE A  93
ASP A 176
PHE A 177
 2KC  A 401 ( 3.2A)
None
2KC  A 401 (-2.7A)
None
 0.77A 5hieA-4nfnA:
4.6		 5hieA-4nfnA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nfn TAU-TUBULIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A  40
GLY A  41
PHE A  93
ASP A 176
 2KC  A 401 ( 3.9A)
2KC  A 401 ( 3.2A)
None
2KC  A 401 (-2.7A)
 0.66A 5hieA-4nfnA:
4.6		 5hieA-4nfnA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qme AMINOPEPTIDASE N

(Neisseria
meningitidis) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		4 ILE A 861
GLY A 859
ASP A 813
PHE A 815
 None
 0.94A 5hieA-4qmeA:
undetectable		 5hieA-4qmeA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xb3 GLUCAN
1,6-ALPHA-GLUCOSIDAS
E

(Streptococcus
mutans) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 ILE A 396
GLY A 397
PHE A 158
ASP A 313
 None
 0.84A 5hieA-4xb3A:
undetectable		 5hieA-4xb3A:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE

(Bacillus
licheniformis) 		PF01019
(G_glu_transpept) 		4 ILE A 396
GLY A 397
PHE A  92
ASP A 441
 None
None
None
NA  A 601 (-3.3A)
 1.04A 5hieA-4y23A:
undetectable		 5hieA-4y23A:
18.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ILE A 469
GLY A 470
ASP A 606
PHE A 607
 4CV  A 801 (-4.3A)
4CV  A 801 ( 3.9A)
4CV  A 801 (-3.5A)
None
 0.87A 5hieA-4yffA:
25.5		 5hieA-4yffA:
31.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e66 HEMAGGLUTININ-ESTERA
SE

(Influenza D
virus) 		PF02710
(Hema_HEFG)
PF03996
(Hema_esterase) 		4 ILE A 257
GLY A 258
PHE A  93
PHE A 138
 None
 1.06A 5hieA-5e66A:
undetectable		 5hieA-5e66A:
19.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fd2 SERINE/THREONINE-PRO
TEIN KINASE B-RAF

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ILE A 463
GLY A 464
CYH A 532
PHE A 595
 5XJ  A 801 ( 4.7A)
None
5XJ  A 801 (-4.6A)
5XJ  A 801 (-3.7A)
 0.75A 5hieA-5fd2A:
35.6		 5hieA-5fd2A:
97.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fd2 SERINE/THREONINE-PRO
TEIN KINASE B-RAF

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ILE A 463
GLY A 464
PHE A 516
CYH A 532
 5XJ  A 801 ( 4.7A)
None
None
5XJ  A 801 (-4.6A)
 0.46A 5hieA-5fd2A:
35.6		 5hieA-5fd2A:
97.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g2v N-ACETYLGLUCOSAMINE-
6-SULFATASE

(Bacteroides
thetaiotaomicron) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		4 ILE A 123
GLY A 124
PHE A 102
CYH A 190
 None
 0.81A 5hieA-5g2vA:
undetectable		 5hieA-5g2vA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzt CHITINASE

(Paenibacillus
sp. FPU-7) 		PF00704
(Glyco_hydro_18) 		4 ILE B1410
GLY B1408
PHE B1342
ASP B1401
 None
 0.87A 5hieA-5gztB:
undetectable		 5hieA-5gztB:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzu CHITINASE

(Paenibacillus
sp. FPU-7) 		PF00704
(Glyco_hydro_18) 		4 ILE A1410
GLY A1408
PHE A1342
ASP A1401
 None
 0.89A 5hieA-5gzuA:
undetectable		 5hieA-5gzuA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ho4 HETEROGENEOUS
NUCLEAR
RIBONUCLEOPROTEINS
A2/B1

(Homo sapiens) 		PF00076
(RRM_1) 		4 ILE A  25
GLY A  65
PHE A  20
ASP A  49
 None
None
None
G  B   4 ( 2.9A)
 0.64A 5hieA-5ho4A:
undetectable		 5hieA-5ho4A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i84 PHOSPHATE-BINDING
PROTEIN PSTS

(Xanthomonas
citri) 		PF12849
(PBP_like_2) 		4 ILE A  66
GLY A  65
PHE A 263
ASP A  80
 PO4  A 404 (-4.2A)
None
None
None
 0.82A 5hieA-5i84A:
undetectable		 5hieA-5i84A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jsy PERIPLASMIC [NIFESE]
HYDROGENASE, SMALL
SUBUNIT

(Desulfovibrio
vulgaris) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		4 ILE A  58
GLY A  92
PHE A 143
ASP A 103
 None
 1.13A 5hieA-5jsyA:
undetectable		 5hieA-5jsyA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k47 POLYCYSTIN-2

(Homo sapiens) 		PF08016
(PKD_channel) 		4 GLY A 376
PHE A 436
ASP A 425
PHE A 426
 None
 1.12A 5hieA-5k47A:
undetectable		 5hieA-5k47A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8s CAMP-DEPENDENT
PROTEIN KINASE
REGULATORY SUBUNIT

(Plasmodium
falciparum) 		PF00027
(cNMP_binding) 		4 ILE A 351
GLY A 372
ASP A 354
PHE A 395
 None
 1.10A 5hieA-5k8sA:
undetectable		 5hieA-5k8sA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kod INDOLE-3-ACETIC
ACID-AMIDO
SYNTHETASE GH3.5

(Arabidopsis
thaliana) 		PF03321
(GH3) 		4 ILE A 541
GLY A 542
PHE A 500
ASP A 489
 None
 1.04A 5hieA-5kodA:
undetectable		 5hieA-5kodA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n0c TETANUS TOXIN

(Clostridium
tetani) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		4 ILE A 918
GLY A 917
ASP A1116
PHE A1305
 None
 1.09A 5hieA-5n0cA:
undetectable		 5hieA-5n0cA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o32 COMPLEMENT FACTOR
H,COMPLEMENT FACTOR
H
COMPLEMENT FACTOR I

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		4 ILE I 407
GLY C 122
PHE C 170
PHE C  93
 None
 0.77A 5hieA-5o32I:
undetectable		 5hieA-5o32I:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t7k AOAA13

(Aspergillus
oryzae) 		PF03067
(LPMO_10) 		4 GLY A   2
PHE A 218
ASP A  90
PHE A 166
 HIC  A   1 ( 2.3A)
None
None
None
 0.92A 5hieA-5t7kA:
undetectable		 5hieA-5t7kA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tr9 FERREDOXIN-NADP
REDUCTASE

(Neisseria
gonorrhoeae) 		PF00175
(NAD_binding_1) 		4 ILE A 132
GLY A 131
PHE A 148
PHE A 229
 None
 0.82A 5hieA-5tr9A:
undetectable		 5hieA-5tr9A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uhp O-GLCNACASE
TIM-BARREL DOMAIN

(Homo sapiens) 		PF07555
(NAGidase) 		4 ILE A 271
GLY A 238
PHE A 145
PHE A 191
 None
 1.07A 5hieA-5uhpA:
undetectable		 5hieA-5uhpA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uqc DIHYDROPYRIMIDINASE-
RELATED PROTEIN 2

(Mus musculus) 		PF01979
(Amidohydro_1) 		4 ILE A 447
GLY A 450
PHE A  90
ASP A 134
 None
 1.00A 5hieA-5uqcA:
undetectable		 5hieA-5uqcA:
19.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vo1 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 12

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 GLY A 134
CYH A 193
ASP A 254
PHE A 255
 9FS  A 501 ( 4.0A)
9FS  A 501 (-4.3A)
None
None
 1.08A 5hieA-5vo1A:
27.2		 5hieA-5vo1A:
34.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vo1 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 12

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 GLY A 137
CYH A 193
ASP A 254
PHE A 255
 None
9FS  A 501 (-4.3A)
None
None
 0.97A 5hieA-5vo1A:
27.2		 5hieA-5vo1A:
34.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7l N,N'-DIACETYLBACILLI
OSAMINYL-1-PHOSPHATE
TRANSFERASE

(Campylobacter
concisus) 		no annotation 4 ILE A 136
GLY A 135
ASP A 169
PHE A 166
 PG4  A 305 (-4.4A)
None
None
None
 0.78A 5hieA-5w7lA:
undetectable		 5hieA-5w7lA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
1

(Saccharomyces
cerevisiae) 		no annotation 4 GLY A 121
PHE A  43
PHE A  82
ASP A 127
 None
 1.11A 5hieA-5y58A:
undetectable		 5hieA-5y58A:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z43 AMBP1

(Fischerella
ambigua) 		no annotation 4 ILE A 160
GLY A 159
ASP A 108
PHE A  59
 None
 0.91A 5hieA-5z43A:
undetectable		 5hieA-5z43A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c6l V-TYPE PROTON ATPASE
SUBUNIT C'
V-TYPE PROTON ATPASE
SUBUNIT C''

(Saccharomyces
cerevisiae) 		no annotation 4 ILE D  43
GLY D  44
PHE C 106
PHE C 190
 None
 1.13A 5hieA-6c6lD:
undetectable		 5hieA-6c6lD:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6caa ELECTROGENIC SODIUM
BICARBONATE
COTRANSPORTER 1

(Homo sapiens) 		no annotation 4 ILE A 513
GLY A 514
PHE A 932
PHE A 752
 None
 1.14A 5hieA-6caaA:
undetectable		 5hieA-6caaA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ei3 PROTON-DEPENDENT
OLIGOPEPTIDE
TRANSPORTER FAMILY
PROTEIN

(Xanthomonas
campestris) 		no annotation 4 ILE A 399
GLY A 397
PHE A 423
PHE A 321
 78M  A 605 ( 4.9A)
None
None
None
 0.99A 5hieA-6ei3A:
1.3		 5hieA-6ei3A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eks SIALIDASE

(Vibrio cholerae) 		no annotation 4 ILE A 356
GLY A 355
PHE A 535
PHE A 466
 None
 1.08A 5hieA-6eksA:
undetectable		 5hieA-6eksA:
17.93