SIMILAR PATTERNS OF AMINO ACIDS FOR 5HIE_A_P06A801

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 VAL A 209
ALA A 220
LYS A 222
ILE A 264
THR A 266
 None
 0.50A 5hieA-1k9aA:
26.8		 5hieA-1k9aA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n2m PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE

(Methanocaldococcus
jannaschii) 		PF01862
(PvlArgDC) 		5 GLY A  23
VAL A  21
ALA A 161
LEU A  48
THR A  75
 None
 0.81A 5hieA-1n2mA:
undetectable		 5hieA-1n2mA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 VAL A 275
ALA A 288
LYS A 290
ILE A 332
THR A 334
 P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
 0.40A 5hieA-1opkA:
25.4		 5hieA-1opkA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tg5 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE

(Arabidopsis
thaliana) 		PF00903
(Glyoxalase) 		6 GLY A 117
PHE A  31
LEU A  47
ILE A 372
THR A 361
GLY A 365
 None
 1.48A 5hieA-1tg5A:
undetectable		 5hieA-1tg5A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1us2 ENDO-BETA-1,4-XYLANA
SE

(Cellvibrio
japonicus) 		PF00331
(Glyco_hydro_10)
PF03426
(CBM_15) 		6 GLY A 105
PHE A 125
VAL A 135
LEU A 166
ILE A 220
GLY A 131
 None
 1.07A 5hieA-1us2A:
undetectable		 5hieA-1us2A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		5 VAL A 613
ALA A 626
ILE A 786
PHE A 842
GLY A 852
 None
GOL  A 998 ( 3.7A)
None
GOL  A 998 ( 4.2A)
None
 0.67A 5hieA-1zy4A:
4.6		 5hieA-1zy4A:
28.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a1a INTERFERON-INDUCED,
DOUBLE-STRANDED
RNA-ACTIVATED
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL B 281
LYS B 296
ILE B 364
PHE B 421
GLY B 431
 None
 0.76A 5hieA-2a1aB:
21.6		 5hieA-2a1aB:
29.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gzo UPF0301 PROTEIN
SO3346

(Shewanella
oneidensis) 		PF02622
(DUF179) 		6 GLY A  76
LEU A 157
LEU A  27
ILE A  40
TRP A 147
GLY A  37
 None
 1.26A 5hieA-2gzoA:
undetectable		 5hieA-2gzoA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 VAL A 281
ALA A 293
LYS A 295
ILE A 336
THR A 338
 H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
H8H  A 534 ( 4.5A)
H8H  A 534 (-3.1A)
 0.45A 5hieA-2h8hA:
26.7		 5hieA-2h8hA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 GLY A 276
VAL A 281
ALA A 293
LYS A 295
ILE A 336
THR A 338
 None
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.3A)
 0.91A 5hieA-2hckA:
27.0		 5hieA-2hckA:
23.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hen EPHRIN TYPE-B
RECEPTOR 2

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 VAL A 643
ALA A 659
LYS A 661
ILE A 705
THR A 707
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 (-2.7A)
None
ADP  A 400 (-4.7A)
 0.61A 5hieA-2henA:
26.3		 5hieA-2henA:
30.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2his CELLULOMONAS FIMI
FAMILY 10
BETA-1,4-GLYCANASE

(Cellulomonas
fimi) 		PF00331
(Glyco_hydro_10) 		6 GLY A 274
VAL A 294
ALA A 304
LEU A 206
ILE A 236
PHE A  15
 None
 1.43A 5hieA-2hisA:
undetectable		 5hieA-2hisA:
20.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 259
ALA A 271
LYS A 273
ILE A 314
THR A 316
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
 0.58A 5hieA-2hk5A:
25.5		 5hieA-2hk5A:
30.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 GLY A 383
VAL A 256
ALA A 269
LYS A 271
THR A 315
 None
GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.4A)
 0.69A 5hieA-2hz0A:
26.7		 5hieA-2hz0A:
29.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 256
ALA A 269
LYS A 271
ILE A 313
THR A 315
 GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.8A)
GIN  A 600 (-3.4A)
 0.43A 5hieA-2hz0A:
26.7		 5hieA-2hz0A:
29.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6l MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  34
ALA A  47
LYS A  49
ILE A 106
PHE A 159
GLY A 170
 None
 0.78A 5hieA-2i6lA:
3.2		 5hieA-2i6lA:
27.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuy GLYCOSYLTRANSFERASE

(Streptomyces
viridochromogenes) 		PF00534
(Glycos_transf_1) 		6 GLY A 104
VAL A  19
ALA A  17
LEU A 345
LEU A 111
ILE A 118
 None
 1.21A 5hieA-2iuyA:
undetectable		 5hieA-2iuyA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		5 VAL A 436
ALA A 452
LYS A 454
ILE A 497
GLY A 563
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
None
None
 0.62A 5hieA-2j0jA:
27.7		 5hieA-2j0jA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		5 VAL A 436
ALA A 452
LYS A 454
ILE A 497
GLY A 563
 BII  A1687 ( 4.7A)
BII  A1687 (-3.5A)
BII  A1687 (-2.9A)
None
BII  A1687 ( 3.9A)
 0.59A 5hieA-2jkmA:
27.3		 5hieA-2jkmA:
27.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 259
ALA A 271
LYS A 273
ILE A 314
THR A 316
 None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.4A)
1N8  A 501 ( 4.6A)
1N8  A 501 ( 3.3A)
 0.60A 5hieA-2og8A:
26.0		 5hieA-2og8A:
34.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 798
VAL A 596
ALA A 614
LYS A 616
LEU A 634
THR A 663
 None
 1.16A 5hieA-2ogvA:
24.1		 5hieA-2ogvA:
28.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 798
VAL A 596
ALA A 614
LYS A 616
THR A 663
GLY A 795
 None
 0.72A 5hieA-2ogvA:
24.1		 5hieA-2ogvA:
28.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A 199
VAL A 204
ALA A 215
LYS A 217
LEU A 245
THR A 265
 None
ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
ADE  A 488 ( 4.5A)
ADE  A 488 (-4.3A)
 0.61A 5hieA-2qluA:
25.7		 5hieA-2qluA:
28.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qob EPHRIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 GLY A 630
VAL A 635
ALA A 651
ILE A 697
THR A 699
 None
BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
 0.74A 5hieA-2qobA:
26.2		 5hieA-2qobA:
31.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		5 GLY A 684
VAL A 689
ALA A 705
ILE A 751
THR A 753
 None
 0.70A 5hieA-2r2pA:
26.2		 5hieA-2r2pA:
32.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xb6 NEUREXIN-1-BETA

(Rattus
norvegicus) 		PF02210
(Laminin_G_2) 		6 GLY C  93
PHE C  89
VAL C 282
ILE C  96
THR C  97
GLY C 247
 None
 1.27A 5hieA-2xb6C:
undetectable		 5hieA-2xb6C:
21.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 VAL A 635
ALA A 651
LYS A 653
ILE A 697
THR A 699
 Q9G  A1898 ( 4.7A)
Q9G  A1898 (-3.2A)
Q9G  A1898 (-4.8A)
Q9G  A1898 ( 4.6A)
Q9G  A1898 (-3.5A)
 0.56A 5hieA-2xyuA:
26.6		 5hieA-2xyuA:
30.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2w WEE1-LIKE PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A 313
ALA A 326
ILE A 374
PHE A 433
GLY A 462
 770  A 901 ( 4.7A)
770  A 901 (-3.5A)
None
770  A 901 (-4.0A)
None
 0.67A 5hieA-2z2wA:
4.3		 5hieA-2z2wA:
25.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z8c INSULIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 GLY A1005
VAL A1010
ALA A1028
LYS A1030
GLY A1149
 None
S91  A   1 ( 4.9A)
S91  A   1 (-3.2A)
S91  A   1 ( 4.2A)
None
 0.73A 5hieA-2z8cA:
26.0		 5hieA-2z8cA:
32.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 VAL A 261
ALA A 273
LYS A 275
ILE A 317
THR A 319
 None
 0.52A 5hieA-2zv7A:
26.5		 5hieA-2zv7A:
33.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 209
ALA A 220
LYS A 222
ILE A 264
THR A 266
 None
 0.50A 5hieA-3d7uA:
10.5		 5hieA-3d7uA:
29.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		5 VAL A 649
ALA A 665
LYS A 667
ILE A 711
THR A 713
 None
 0.78A 5hieA-3kulA:
27.4		 5hieA-3kulA:
33.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		5 GLY A 213
VAL A 218
ALA A 229
LEU A 259
THR A 279
 LDN  A   1 ( 4.4A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
LDN  A   1 (-3.8A)
 0.69A 5hieA-3mdyA:
25.7		 5hieA-3mdyA:
29.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		5 VAL A 218
ALA A 229
LYS A 231
LEU A 259
THR A 279
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
None
LDN  A   1 (-3.8A)
 0.62A 5hieA-3mdyA:
25.7		 5hieA-3mdyA:
29.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 PHE A 231
VAL A 216
ALA A 227
LEU A 257
THR A 277
 None
LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
None
LDN  A 600 (-4.0A)
 0.78A 5hieA-3my0A:
24.7		 5hieA-3my0A:
28.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 216
ALA A 227
LYS A 229
LEU A 257
THR A 277
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
None
LDN  A 600 (-4.0A)
 0.40A 5hieA-3my0A:
24.7		 5hieA-3my0A:
28.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 GLY A 358
ALA A 373
LYS A 375
LEU A 406
ILE A 419
THR A 421
PHE A 475
GLY A 485
 None
SM5  A   1 (-3.6A)
SM5  A   1 (-3.5A)
None
SM5  A   1 ( 4.3A)
SM5  A   1 (-4.4A)
SM5  A   1 (-3.0A)
None
 0.92A 5hieA-3omvA:
34.7		 5hieA-3omvA:
77.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 358
VAL A 363
ALA A 373
LEU A 397
ILE A 419
THR A 421
TRP A 423
 None
SM5  A   1 (-4.0A)
SM5  A   1 (-3.6A)
None
SM5  A   1 ( 4.3A)
SM5  A   1 (-4.4A)
SM5  A   1 (-4.3A)
 1.02A 5hieA-3omvA:
34.7		 5hieA-3omvA:
77.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 GLY A 358
VAL A 363
ALA A 373
LEU A 406
ILE A 419
THR A 421
TRP A 423
PHE A 475
GLY A 485
 None
SM5  A   1 (-4.0A)
SM5  A   1 (-3.6A)
None
SM5  A   1 ( 4.3A)
SM5  A   1 (-4.4A)
SM5  A   1 (-4.3A)
SM5  A   1 (-3.0A)
None
 0.79A 5hieA-3omvA:
34.7		 5hieA-3omvA:
77.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3poy NEUREXIN-1-ALPHA

(Bos taurus) 		PF00008
(EGF)
PF02210
(Laminin_G_2) 		6 GLY A1155
PHE A1151
VAL A1344
ILE A1158
THR A1159
GLY A1309
 None
 1.27A 5hieA-3poyA:
undetectable		 5hieA-3poyA:
14.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3q4t ACTIVIN RECEPTOR
TYPE-2A

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A 201
VAL A 206
ALA A 217
LEU A 247
THR A 267
 None
TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
None
TAK  A   2 (-3.5A)
 0.57A 5hieA-3q4tA:
25.7		 5hieA-3q4tA:
30.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3q4t ACTIVIN RECEPTOR
TYPE-2A

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A 206
ALA A 217
LYS A 219
LEU A 247
THR A 267
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
None
TAK  A   2 (-3.5A)
 0.55A 5hieA-3q4tA:
25.7		 5hieA-3q4tA:
30.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q60 ROP5B

(Toxoplasma
gondii) 		PF14531
(Kinase-like) 		6 VAL A 248
ALA A 261
LYS A 263
LEU A 304
PHE A 396
GLY A 406
 ATP  A 600 (-4.3A)
ATP  A 600 (-3.6A)
MLI  A 601 ( 2.8A)
ATP  A 600 ( 4.8A)
ATP  A 600 (-4.4A)
None
 0.87A 5hieA-3q60A:
7.4		 5hieA-3q60A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		5 ALA B 616
LYS B 618
ILE B 884
PHE B 942
GLY B 952
 None
 0.61A 5hieA-3qd2B:
21.5		 5hieA-3qd2B:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		5 GLY B 599
ALA B 616
LYS B 618
PHE B 942
GLY B 952
 None
 0.52A 5hieA-3qd2B:
21.5		 5hieA-3qd2B:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		5 GLY B 599
VAL B 603
ALA B 616
PHE B 942
GLY B 952
 None
 0.58A 5hieA-3qd2B:
21.5		 5hieA-3qd2B:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		5 VAL B 603
ALA B 616
ILE B 884
PHE B 942
GLY B 952
 None
 0.68A 5hieA-3qd2B:
21.5		 5hieA-3qd2B:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3she MAP KINASE-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  53
VAL A  58
ALA A  71
LYS A  73
ILE A 116
 I85  A 350 (-3.1A)
I85  A 350 (-4.9A)
I85  A 350 (-3.3A)
I85  A 350 (-2.8A)
None
 0.65A 5hieA-3sheA:
3.4		 5hieA-3sheA:
26.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 426
VAL A 431
ALA A 443
LYS A 445
ILE A 487
THR A 489
 PP2  A   1 ( 4.8A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.6A)
PP2  A   1 (-3.3A)
 0.63A 5hieA-3sxsA:
26.4		 5hieA-3sxsA:
31.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsm INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE

(Brucella
abortus) 		PF00218
(IGPS) 		5 GLY A  41
ALA A  56
LEU A 218
ILE A  58
THR A 241
 None
 0.79A 5hieA-3tsmA:
undetectable		 5hieA-3tsmA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vot L-AMINO ACID LIGASE,
BL00235

(Bacillus
licheniformis) 		PF13535
(ATP-grasp_4) 		5 VAL A 287
ALA A 270
ILE A 208
THR A 210
GLY A 258
 None
 0.75A 5hieA-3votA:
undetectable		 5hieA-3votA:
20.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A1959
ALA A1978
LYS A1980
LEU A2010
ILE A2024
GLY A2101
 None
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
VGH  A3000 (-4.8A)
None
VGH  A3000 (-3.5A)
 0.73A 5hieA-3zbfA:
10.7		 5hieA-3zbfA:
32.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 633
ALA A 649
LYS A 651
ILE A 695
THR A 697
 None
 0.59A 5hieA-3zfxA:
27.1		 5hieA-3zfxA:
32.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  62
ALA A  80
LYS A  82
PHE A 183
GLY A 193
 939  A1331 ( 3.7A)
939  A1331 (-3.5A)
939  A1331 (-2.6A)
939  A1331 (-4.0A)
None
 0.75A 5hieA-4a4lA:
23.5		 5hieA-4a4lA:
27.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 100
VAL A 105
ALA A 121
LYS A 123
ILE A 167
THR A 169
 30K  A1365 ( 4.4A)
30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
None
30K  A1365 (-3.8A)
 0.69A 5hieA-4aw5A:
26.7		 5hieA-4aw5A:
31.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  89
LYS A  91
ILE A 137
PHE A 192
GLY A 202
 9ZP  A1333 (-3.5A)
None
None
9ZP  A1333 (-3.6A)
9ZP  A1333 ( 4.4A)
 0.78A 5hieA-4b6lA:
23.1		 5hieA-4b6lA:
27.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		5 PHE A 237
VAL A 222
ALA A 233
LEU A 263
THR A 283
 None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
FLC  A1503 ( 4.5A)
TAK  A1507 (-3.6A)
 0.77A 5hieA-4c02A:
24.3		 5hieA-4c02A:
28.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		5 VAL A 222
ALA A 233
LYS A 235
LEU A 263
THR A 283
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
FLC  A1503 ( 4.5A)
TAK  A1507 (-3.6A)
 0.37A 5hieA-4c02A:
24.3		 5hieA-4c02A:
28.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 GLY A 786
VAL A 624
ALA A 653
LYS A 655
THR A 701
 None
DI1  A1000 (-4.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.9A)
DI1  A1000 (-3.6A)
 0.78A 5hieA-4ckrA:
10.4		 5hieA-4ckrA:
31.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A1130
ALA A1148
LYS A1150
ILE A1194
GLY A1269
 0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
0UV  A1501 (-3.7A)
None
0UV  A1501 (-4.5A)
 0.78A 5hieA-4fodA:
25.7		 5hieA-4fodA:
29.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A 606
ALA A 619
ILE A 885
PHE A 943
GLY A 953
 924  A1101 ( 4.8A)
924  A1101 (-3.5A)
924  A1101 ( 4.6A)
924  A1101 ( 4.2A)
924  A1101 (-4.6A)
 0.49A 5hieA-4g34A:
3.8		 5hieA-4g34A:
28.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A 606
ALA A 619
LYS A 621
ILE A 885
GLY A 953
 924  A1101 ( 4.8A)
924  A1101 (-3.5A)
None
924  A1101 ( 4.6A)
924  A1101 (-4.6A)
 0.75A 5hieA-4g34A:
3.8		 5hieA-4g34A:
28.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 GLY A 858
VAL A 863
ALA A 880
LYS A 882
GLY A 993
 IZA  A2001 ( 3.7A)
None
IZA  A2001 (-3.4A)
IZA  A2001 ( 4.7A)
None
 0.67A 5hieA-4gl9A:
25.1		 5hieA-4gl9A:
29.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzs ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14604
(SH3_9) 		5 GLY A 135
VAL A 140
ALA A 156
LYS A 158
THR A 205
 None
 0.54A 5hieA-4hzsA:
25.7		 5hieA-4hzsA:
29.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzs ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14604
(SH3_9) 		5 VAL A 140
ALA A 156
LYS A 158
THR A 205
GLY A 269
 None
 0.66A 5hieA-4hzsA:
25.7		 5hieA-4hzsA:
29.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A 109
LYS A 111
ILE A 157
PHE A 212
GLY A 222
 1C7  A 401 (-3.2A)
1C7  A 401 ( 4.7A)
None
1C7  A 401 (-4.0A)
None
 0.63A 5hieA-4i6fA:
21.7		 5hieA-4i6fA:
27.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4id7 ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 140
ALA A 156
LYS A 158
THR A 205
GLY A 269
 1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
1G0  A 401 (-3.2A)
None
 0.53A 5hieA-4id7A:
25.8		 5hieA-4id7A:
30.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l5i TRANSCRIPTIONAL
REGULATOR LSRR

(Escherichia
coli) 		PF04198
(Sugar-bind) 		6 GLY A 105
VAL A 305
ALA A 303
LEU A 120
LEU A 113
ILE A 207
 None
 0.99A 5hieA-4l5iA:
undetectable		 5hieA-4l5iA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		5 GLY A  31
VAL A  36
ALA A  49
LYS A  51
THR A  95
 ANP  A 401 (-3.4A)
ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
ANP  A 401 (-3.8A)
 0.57A 5hieA-4m69A:
26.6		 5hieA-4m69A:
27.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		5 VAL A  36
ALA A  49
LYS A  51
LEU A  74
THR A  95
 ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
None
ANP  A 401 (-3.8A)
 0.75A 5hieA-4m69A:
26.6		 5hieA-4m69A:
27.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p2k EPHRIN TYPE-A
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		5 GLY A 622
VAL A 627
ALA A 644
ILE A 690
THR A 692
 None
 0.71A 5hieA-4p2kA:
26.7		 5hieA-4p2kA:
33.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qwo PROFILIN

(Monkeypox virus) 		PF00235
(Profilin) 		5 VAL A  23
ALA A  21
LEU A  84
ILE A  96
GLY A  63
 None
 0.76A 5hieA-4qwoA:
undetectable		 5hieA-4qwoA:
18.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		5 VAL A  22
ALA A  35
LYS A  37
ILE A  79
THR A  81
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
 0.45A 5hieA-4ueuA:
26.4		 5hieA-4ueuA:
34.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 5 VAL B 275
ALA B 288
LYS B 290
ILE B 332
THR B 334
 1N1  B 601 ( 4.9A)
1N1  B 601 (-3.5A)
1N1  B 601 (-4.6A)
1N1  B 601 (-4.1A)
1N1  B 601 (-3.3A)
 0.33A 5hieA-4xeyB:
26.6		 5hieA-4xeyB:
25.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 GLY A 411
VAL A 416
ALA A 428
ILE A 472
THR A 474
 None
 0.64A 5hieA-4xi2A:
10.2		 5hieA-4xi2A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		5 GLY A 411
VAL A 416
ALA A 428
ILE A 472
THR A 474
 746  A 702 (-3.0A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
None
746  A 702 (-3.7A)
 0.31A 5hieA-4y93A:
27.8		 5hieA-4y93A:
23.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 477
ALA A 488
LYS A 490
ILE A 537
THR A 539
 None
4CV  A 801 (-3.5A)
4CV  A 801 (-3.9A)
None
4CV  A 801 (-2.8A)
 0.64A 5hieA-4yffA:
25.5		 5hieA-4yffA:
31.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8y TGF-BETA RECEPTOR
TYPE-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 GLY A 253
VAL A 258
ALA A 275
LYS A 277
THR A 325
 STU  A 601 ( 3.9A)
STU  A 601 (-4.0A)
STU  A 601 (-3.1A)
STU  A 601 (-2.4A)
STU  A 601 ( 3.7A)
 0.75A 5hieA-5e8yA:
25.0		 5hieA-5e8yA:
28.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8y TGF-BETA RECEPTOR
TYPE-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 PHE A 279
VAL A 258
ALA A 275
LYS A 277
LEU A 305
THR A 325
 None
STU  A 601 (-4.0A)
STU  A 601 (-3.1A)
STU  A 601 (-2.4A)
STU  A 601 ( 3.8A)
STU  A 601 ( 3.7A)
 1.14A 5hieA-5e8yA:
25.0		 5hieA-5e8yA:
28.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyk AURORA KINASE B-A

(Xenopus laevis) 		PF00069
(Pkinase) 		5 GLY A 102
VAL A 107
ALA A 120
LYS A 122
LEU A 154
 5U5  A 401 ( 4.6A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-2.6A)
5U5  A 401 (-4.8A)
 0.81A 5hieA-5eykA:
22.3		 5hieA-5eykA:
25.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fd2 SERINE/THREONINE-PRO
TEIN KINASE B-RAF

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 VAL A 471
ALA A 481
LYS A 483
LEU A 505
LEU A 514
ILE A 527
THR A 529
TRP A 531
PHE A 583
 5XJ  A 801 (-4.6A)
5XJ  A 801 (-3.1A)
5XJ  A 801 (-3.8A)
5XJ  A 801 (-3.8A)
5XJ  A 801 (-4.5A)
5XJ  A 801 ( 4.0A)
5XJ  A 801 (-3.4A)
5XJ  A 801 (-4.4A)
5XJ  A 801 (-4.3A)
 0.64A 5hieA-5fd2A:
35.2		 5hieA-5fd2A:
97.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fd2 SERINE/THREONINE-PRO
TEIN KINASE B-RAF

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 VAL A 471
ALA A 481
LYS A 483
LEU A 514
ILE A 527
THR A 529
TRP A 531
PHE A 583
GLY A 593
 5XJ  A 801 (-4.6A)
5XJ  A 801 (-3.1A)
5XJ  A 801 (-3.8A)
5XJ  A 801 (-4.5A)
5XJ  A 801 ( 4.0A)
5XJ  A 801 (-3.4A)
5XJ  A 801 (-4.4A)
5XJ  A 801 (-4.3A)
5XJ  A 801 ( 3.7A)
 0.56A 5hieA-5fd2A:
35.2		 5hieA-5fd2A:
97.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 GLY A 838
ALA A 625
LYS A 627
ILE A 672
THR A 674
 None
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.9A)
748  A1001 (-3.2A)
 0.80A 5hieA-5grnA:
10.0		 5hieA-5grnA:
28.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 607
ALA A 625
LYS A 627
LEU A 645
ILE A 672
THR A 674
 748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
None
748  A1001 (-3.9A)
748  A1001 (-3.2A)
 1.25A 5hieA-5grnA:
10.0		 5hieA-5grnA:
28.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A  30
ALA A  43
LYS A  45
LEU A  57
ILE A  80
THR A  82
 032  A 401 (-4.4A)
032  A 401 (-3.2A)
032  A 401 (-4.4A)
032  A 401 ( 4.7A)
032  A 401 (-4.0A)
032  A 401 (-3.7A)
 0.70A 5hieA-5hesA:
26.4		 5hieA-5hesA:
31.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5kkr KINASE SUPPRESSOR OF
RAS 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL B 680
ALA B 690
ILE B 737
THR B 739
PHE B 793
 6U7  B1001 ( 4.3A)
6U7  B1001 (-3.6A)
6U7  B1001 ( 4.1A)
6U7  B1001 (-4.0A)
6U7  B1001 (-4.3A)
 0.54A 5hieA-5kkrB:
25.1		 5hieA-5kkrB:
35.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m09 SERINE/THREONINE-PRO
TEIN KINASE PKNI

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase) 		5 VAL A  26
ALA A  39
LYS A  41
LEU A  73
ILE A  87
 None
 0.65A 5hieA-5m09A:
20.3		 5hieA-5m09A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o2c SERINE/THREONINE-PRO
TEIN KINASE WNK3

(Homo sapiens) 		PF00069
(Pkinase)
PF12202
(OSR1_C) 		5 VAL A 161
ALA A 174
THR A 227
PHE A 282
GLY A 293
 None
GOL  A 604 ( 3.8A)
GOL  A 604 (-3.9A)
GOL  A 604 ( 4.5A)
GOL  A 604 ( 4.6A)
 0.62A 5hieA-5o2cA:
10.1		 5hieA-5o2cA:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A 124
ALA A 137
THR A 187
PHE A 240
GLY A 250
 H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
None
 0.64A 5hieA-5vcxA:
7.0		 5hieA-5vcxA:
27.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vdk WEE1-LIKE PROTEIN
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A 221
VAL A 226
ALA A 239
ILE A 287
PHE A 346
GLY A 379
 8X7  A 501 (-3.4A)
8X7  A 501 ( 4.5A)
8X7  A 501 ( 3.7A)
PO4  A 502 (-3.4A)
8X7  A 501 (-3.7A)
None
 0.83A 5hieA-5vdkA:
22.0		 5hieA-5vdkA:
29.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5

(Homo sapiens) 		no annotation 5 GLY A 689
VAL A 694
ALA A 707
LYS A 709
ILE A 752
 9E1  A1001 (-2.9A)
9E1  A1001 ( 4.0A)
9E1  A1001 (-3.5A)
9E1  A1001 (-2.8A)
None
 0.71A 5hieA-5vilA:
9.1		 5hieA-5vilA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2

(Homo sapiens) 		no annotation 7 GLY A  27
VAL A  32
ALA A  45
LYS A  47
LEU A  79
ILE A  93
THR A  95
 None
9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.3A)
9WS  A 401 (-4.9A)
9WS  A 401 (-3.9A)
9WS  A 401 (-3.2A)
 0.71A 5hieA-5w5jA:
26.6		 5hieA-5w5jA:
29.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 6 GLY A 894
VAL A 899
ALA A 917
LYS A 919
ILE A 961
THR A 963
 ANP  A1201 (-2.8A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
None
ANP  A1201 (-3.9A)
 0.67A 5hieA-5wnoA:
25.3		 5hieA-5wnoA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 5 VAL A 899
ALA A 917
LEU A 947
ILE A 961
THR A 963
 ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-4.7A)
None
ANP  A1201 (-3.9A)
 0.55A 5hieA-5wnoA:
25.3		 5hieA-5wnoA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x1t PPKA-294

(Serratia sp.
FS14) 		no annotation 6 GLY A  35
PHE A  86
VAL A  37
ALA A  50
LEU A 102
THR A 118
 None
None
ADP  A 401 ( 4.5A)
ADP  A 401 (-3.4A)
None
ADP  A 401 (-4.1A)
 1.33A 5hieA-5x1tA:
7.5		 5hieA-5x1tA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cth CONCANAVALIN A-LIKE
LECTIN PROTEIN
KINASE FAMILY
PROTEIN

(Theobroma cacao) 		no annotation 5 PHE A 280
VAL A 283
ALA A 296
LYS A 298
GLY A 410
 None
FE7  A 601 ( 4.3A)
FE7  A 601 (-3.3A)
FE7  A 601 (-3.6A)
FE7  A 601 ( 4.1A)
 0.72A 5hieA-6cthA:
6.4		 5hieA-6cthA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cz4 PROTEIN-TYROSINE
KINASE 6

(Homo sapiens) 		no annotation 5 ALA A 217
LEU A 248
ILE A 262
THR A 264
GLY A 329
 FKY  A9001 (-3.3A)
FKY  A9001 (-4.2A)
None
FKY  A9001 (-3.0A)
FKY  A9001 (-3.4A)
 0.63A 5hieA-6cz4A:
25.6		 5hieA-6cz4A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cz4 PROTEIN-TYROSINE
KINASE 6

(Homo sapiens) 		no annotation 6 GLY A 200
VAL A 205
ALA A 217
LYS A 219
LEU A 336
ILE A 262
 None
FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
None
None
None
 1.29A 5hieA-6cz4A:
25.6		 5hieA-6cz4A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cz4 PROTEIN-TYROSINE
KINASE 6

(Homo sapiens) 		no annotation 5 VAL A 205
ALA A 217
LEU A 248
ILE A 262
THR A 264
 FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
FKY  A9001 (-4.2A)
None
FKY  A9001 (-3.0A)
 0.53A 5hieA-6cz4A:
25.6		 5hieA-6cz4A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cz4 PROTEIN-TYROSINE
KINASE 6

(Homo sapiens) 		no annotation 5 VAL A 205
ALA A 217
LYS A 219
ILE A 262
THR A 264
 FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
None
None
FKY  A9001 (-3.0A)
 0.72A 5hieA-6cz4A:
25.6		 5hieA-6cz4A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ahi 7
ALPHA-HYDROXYSTEROID
DEHYDROGENASE

(Escherichia
coli) 		PF13561
(adh_short_C2) 		4 ILE A  27
GLY A  24
PHE A  81
PHE A  63
 None
 1.06A 5hieA-1ahiA:
undetectable		 5hieA-1ahiA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dll TETANUS TOXIN

(Clostridium
tetani) 		PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N) 		4 ILE A 918
GLY A 917
ASP A1116
PHE A1305
 None
 1.12A 5hieA-1dllA:
undetectable		 5hieA-1dllA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f80 HOLO-(ACYL CARRIER
PROTEIN) SYNTHASE

(Bacillus
subtilis) 		PF01648
(ACPS) 		4 ILE A 103
GLY A  52
PHE A  64
ASP A   8
 None
 0.98A 5hieA-1f80A:
undetectable		 5hieA-1f80A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hl2 N-ACETYLNEURAMINATE
LYASE SUBUNIT

(Escherichia
coli) 		PF00701
(DHDPS) 		4 ILE A 206
GLY A 205
PHE A  33
ASP A  40
 3PY  A 802 ( 4.9A)
None
None
None
 0.73A 5hieA-1hl2A:
undetectable		 5hieA-1hl2A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jc2 TROPONIN C, SKELETAL
MUSCLE

(Gallus gallus) 		PF13499
(EF-hand_7) 		4 ILE A 134
GLY A 119
PHE A 102
PHE A 112
 None
 1.12A 5hieA-1jc2A:
undetectable		 5hieA-1jc2A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pox PYRUVATE OXIDASE

(Lactobacillus
plantarum) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 ILE A 426
GLY A 425
PHE A 526
PHE A 514
 None
 1.06A 5hieA-1poxA:
0.0		 5hieA-1poxA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1px8 BETA-XYLOSIDASE

(Thermoanaerobacterium
saccharolyticum) 		PF01229
(Glyco_hydro_39) 		4 ILE A 142
GLY A 146
PHE A  97
PHE A  89
 None
 0.94A 5hieA-1px8A:
undetectable		 5hieA-1px8A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6m ACETYLTRANSFERASE,
GNAT FAMILY

(Enterococcus
faecalis) 		PF00583
(Acetyltransf_1) 		4 ILE A 129
GLY A 128
PHE A 169
ASP A 135
 None
SO4  A1003 ( 4.3A)
None
None
 0.57A 5hieA-1u6mA:
undetectable		 5hieA-1u6mA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1us7 HSP90 CO-CHAPERONE
CDC37

(Homo sapiens) 		PF08564
(CDC37_C)
PF08565
(CDC37_M) 		4 ILE B 159
PHE B 237
CYH B 194
PHE B 218
 None
 1.10A 5hieA-1us7B:
undetectable		 5hieA-1us7B:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1us8 DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE

(Pyrococcus
furiosus) 		PF13476
(AAA_23)
no annotation 		4 ILE A 143
GLY A 141
PHE A 132
ASP B 822
 None
 1.13A 5hieA-1us8A:
undetectable		 5hieA-1us8A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xq1 PUTATIVE TROPINONE
REDUCATSE

(Arabidopsis
thaliana) 		PF13561
(adh_short_C2) 		4 ILE A  26
GLY A  27
PHE A  37
PHE A 235
 None
 1.12A 5hieA-1xq1A:
undetectable		 5hieA-1xq1A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yq3 SUCCINATE
DEHYDROGENASE IP
SUBUNIT

(Gallus gallus) 		PF13085
(Fer2_3)
PF13534
(Fer4_17) 		4 ILE B  77
GLY B  80
PHE B 118
CYH B  85
 None
None
None
FES  B1002 (-2.2A)
 0.82A 5hieA-1yq3B:
undetectable		 5hieA-1yq3B:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a1r POLY(A)-SPECIFIC
RIBONUCLEASE PARN

(Homo sapiens) 		PF01424
(R3H)
PF04857
(CAF1) 		4 ILE A  34
GLY A  33
PHE A 300
PHE A  69
 A  C 502 ( 4.1A)
A  C 503 ( 3.8A)
None
None
 1.09A 5hieA-2a1rA:
undetectable		 5hieA-2a1rA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bx7 DIHYDROOROTATE
DEHYDROGENASE

(Lactococcus
lactis) 		PF01180
(DHO_dh) 		4 ILE A 224
GLY A 221
PHE A  15
ASP A 256
 FMN  A1312 ( 4.9A)
FMN  A1312 (-3.6A)
None
None
 1.01A 5hieA-2bx7A:
undetectable		 5hieA-2bx7A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e18 NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Pyrococcus
horikoshii) 		PF02540
(NAD_synthase) 		4 ILE A 195
GLY A 194
PHE A 135
ASP A 189
 None
 1.13A 5hieA-2e18A:
undetectable		 5hieA-2e18A:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2efj 3,7-DIMETHYLXANTHINE
METHYLTRANSFERASE

(Coffea
canephora) 		PF03492
(Methyltransf_7) 		4 ILE A  74
PHE A 292
PHE A 225
PHE A  27
 None
None
None
37T  A 502 (-4.6A)
 1.11A 5hieA-2efjA:
undetectable		 5hieA-2efjA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hi9 PLASMA SERINE
PROTEASE INHIBITOR

(Homo sapiens) 		PF00079
(Serpin) 		4 ILE A 304
GLY A 303
ASP A  32
PHE A  31
 None
 1.13A 5hieA-2hi9A:
undetectable		 5hieA-2hi9A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2htv NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 ILE A 106
GLY A 105
PHE A 446
PHE A 374
 None
 0.65A 5hieA-2htvA:
undetectable		 5hieA-2htvA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iou MAJOR TROPISM
DETERMINANT P1

(Bordetella
virus BPP1) 		no annotation 4 ILE A 212
GLY A 197
PHE A 341
ASP A 192
 None
 1.01A 5hieA-2iouA:
undetectable		 5hieA-2iouA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iv0 ISOCITRATE
DEHYDROGENASE

(Archaeoglobus
fulgidus) 		PF00180
(Iso_dh) 		4 ILE A 159
GLY A 158
PHE A 197
ASP A 154
 None
 1.01A 5hieA-2iv0A:
undetectable		 5hieA-2iv0A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1v ENDOPLASMIN

(Canis lupus) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		4 ILE A 492
GLY A 489
ASP A 573
PHE A 540
 None
 0.98A 5hieA-2o1vA:
undetectable		 5hieA-2o1vA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oe1 THIOREDOXIN-3

(Saccharomyces
cerevisiae) 		PF00085
(Thioredoxin) 		4 ILE A  90
GLY A  91
CYH A  69
ASP A  26
 None
None
SO4  A1002 ( 4.8A)
None
 0.92A 5hieA-2oe1A:
undetectable		 5hieA-2oe1A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pg6 CYTOCHROME P450 2A6

(Homo sapiens) 		PF00067
(p450) 		4 GLY A 336
PHE A 452
ASP A 345
PHE A 343
 None
 0.85A 5hieA-2pg6A:
undetectable		 5hieA-2pg6A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pgw MUCONATE
CYCLOISOMERASE

(Sinorhizobium
meliloti) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ILE A 275
GLY A 276
CYH A 269
PHE A 301
 None
 0.84A 5hieA-2pgwA:
undetectable		 5hieA-2pgwA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyx TRYPTOPHAN
HALOGENASE

(Shewanella
frigidimarina) 		PF04820
(Trp_halogenase) 		4 ILE A  72
GLY A  73
PHE A 163
PHE A 522
 None
 0.86A 5hieA-2pyxA:
undetectable		 5hieA-2pyxA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qsr TRANSCRIPTION-REPAIR
COUPLING FACTOR

(Streptococcus
pneumoniae) 		PF03461
(TRCF) 		4 ILE A1043
GLY A1074
ASP A1081
PHE A1084
 None
 0.95A 5hieA-2qsrA:
undetectable		 5hieA-2qsrA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyz UNCHARACTERIZED
PROTEIN

(Clostridium
tetani) 		PF09643
(YopX) 		4 ILE A  71
GLY A 120
CYH A  95
ASP A  60
 None
 0.94A 5hieA-2qyzA:
undetectable		 5hieA-2qyzA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v6g PROGESTERONE
5-BETA-REDUCTASE

(Digitalis
lanata) 		PF01370
(Epimerase) 		4 ILE A 340
GLY A 339
PHE A 287
PHE A 237
 None
 1.12A 5hieA-2v6gA:
undetectable		 5hieA-2v6gA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2veo LIPASE A

(Moesziomyces
antarcticus) 		PF03583
(LIP) 		4 ILE A 404
GLY A 403
PHE A 358
PHE A 380
 None
 1.03A 5hieA-2veoA:
undetectable		 5hieA-2veoA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vr5 GLYCOGEN OPERON
PROTEIN GLGX

(Sulfolobus
solfataricus) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		4 ILE A 284
GLY A 359
PHE A 227
PHE A 249
 None
 1.13A 5hieA-2vr5A:
undetectable		 5hieA-2vr5A:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w49 TROPONIN C, SKELETAL
MUSCLE

(Gallus gallus) 		PF13499
(EF-hand_7)
PF13833
(EF-hand_8) 		4 GLY 0 118
PHE 0 150
ASP 0 113
PHE 0 111
 None
None
CA  01001 ( 4.3A)
None
 0.88A 5hieA-2w490:
undetectable		 5hieA-2w490:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfu CARBOHYDRATE BINDING
FAMILY 6

(Ruminiclostridium
thermocellum) 		no annotation 4 ILE A  94
GLY A  74
PHE A  85
PHE A 114
 None
 1.11A 5hieA-2yfuA:
undetectable		 5hieA-2yfuA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2za1 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Plasmodium
falciparum) 		PF00215
(OMPdecase) 		4 ILE A 296
GLY A 293
PHE A  88
ASP A  28
 None
OMP  A 500 (-3.6A)
None
None
 1.01A 5hieA-2za1A:
undetectable		 5hieA-2za1A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3n DIHYDROOROTATE
DEHYDROGENASE

(Trypanosoma
cruzi) 		PF01180
(DHO_dh) 		4 ILE A 227
GLY A 224
PHE A  17
ASP A 258
 ILE  A 227 (-0.4A)
GLY  A 224 (-0.0A)
PHE  A  17 ( 1.3A)
ASP  A 258 ( 0.5A)
 0.98A 5hieA-3c3nA:
undetectable		 5hieA-3c3nA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cq5 HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Corynebacterium
glutamicum) 		PF00155
(Aminotran_1_2) 		4 ILE A 362
GLY A 299
PHE A 311
ASP A 314
 None
 1.01A 5hieA-3cq5A:
undetectable		 5hieA-3cq5A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d45 POLY(A)-SPECIFIC
RIBONUCLEASE PARN

(Mus musculus) 		PF01424
(R3H)
PF04857
(CAF1)
PF08675
(RNA_bind) 		4 ILE A  34
GLY A  33
PHE A 293
PHE A  69
 GDP  A 652 ( 4.4A)
None
None
None
 1.14A 5hieA-3d45A:
undetectable		 5hieA-3d45A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkh LACCASE-1

(Melanocarpus
albomyces) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 ILE A 419
CYH A 503
ASP A 422
PHE A 427
 None
CU  A 601 (-2.1A)
None
None
 1.04A 5hieA-3dkhA:
undetectable		 5hieA-3dkhA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e18 OXIDOREDUCTASE

(Listeria
innocua) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 GLY A 159
PHE A 210
ASP A 204
PHE A 200
 None
 1.04A 5hieA-3e18A:
undetectable		 5hieA-3e18A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN

(Geobacillus
kaustophilus) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		4 GLY A1183
PHE A1231
CYH A1264
ASP A1215
 None
 0.75A 5hieA-3f2bA:
undetectable		 5hieA-3f2bA:
13.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h11 CASP8 AND FADD-LIKE
APOPTOSIS REGULATOR

(Homo sapiens) 		PF00656
(Peptidase_C14) 		4 ILE A 260
GLY A 261
PHE A 355
PHE A 271
 None
 0.88A 5hieA-3h11A:
undetectable		 5hieA-3h11A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4i UNCHARACTERIZED
PROTEIN

(Pseudomonas
syringae group
genomosp. 3) 		PF03737
(RraA-like) 		4 ILE A 163
GLY A 162
CYH A 178
ASP A 119
 None
 1.03A 5hieA-3k4iA:
undetectable		 5hieA-3k4iA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6u ABC-TYPE SUGAR
TRANSPORT SYSTEM
PERIPLASMIC
COMPONENT

(Exiguobacterium
sibiricum) 		PF13407
(Peripla_BP_4) 		4 GLY A  89
PHE A 258
PHE A  13
ASP A  66
 None
 0.78A 5hieA-3l6uA:
undetectable		 5hieA-3l6uA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l76 ASPARTOKINASE

(Synechocystis
sp. PCC 6803) 		PF00696
(AA_kinase)
PF01842
(ACT)
PF13840
(ACT_7) 		4 ILE A 366
GLY A 364
PHE A 376
PHE A 495
 None
 0.90A 5hieA-3l76A:
undetectable		 5hieA-3l76A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m8l CAPSID PROTEIN

(Feline
calicivirus) 		PF00915
(Calici_coat) 		4 ILE A 550
GLY A 382
PHE A 566
ASP A 422
 None
 1.12A 5hieA-3m8lA:
undetectable		 5hieA-3m8lA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mi9 CELL DIVISION
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A  25
CYH A 106
ASP A 167
PHE A 168
 None
 0.83A 5hieA-3mi9A:
22.7		 5hieA-3mi9A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mkr COATOMER SUBUNIT
ALPHA

(Bos taurus) 		PF06957
(COPI_C) 		4 ILE B 919
GLY B 995
PHE B1223
ASP B 929
 None
 0.91A 5hieA-3mkrB:
undetectable		 5hieA-3mkrB:
20.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ILE A 355
CYH A 424
ASP A 486
PHE A 487
 SM5  A   1 (-4.3A)
SM5  A   1 ( 4.4A)
SM5  A   1 (-3.5A)
None
 0.91A 5hieA-3omvA:
34.7		 5hieA-3omvA:
77.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ILE A 355
GLY A 356
PHE A 408
CYH A 424
 SM5  A   1 (-4.3A)
SM5  A   1 ( 4.9A)
None
SM5  A   1 ( 4.4A)
 0.51A 5hieA-3omvA:
34.7		 5hieA-3omvA:
77.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opy 6-PHOSPHOFRUCTO-1-KI
NASE BETA-SUBUNIT

(Komagataella
pastoris) 		PF00365
(PFK) 		4 ILE B 844
GLY B 843
CYH B 353
ASP B 849
 None
 0.85A 5hieA-3opyB:
undetectable		 5hieA-3opyB:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q46 TT-IPPASE

(Thermococcus
thioreducens) 		PF00719
(Pyrophosphatase) 		4 ILE A  93
GLY A 154
PHE A 116
ASP A 121
 None
 0.89A 5hieA-3q46A:
undetectable		 5hieA-3q46A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qw3 OROTIDINE-5-PHOSPHAT
E
DECARBOXYLASE/OROTAT
E
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE
(OMPDCASE-OPRTASE,
PUTATIVE)

(Leishmania
infantum) 		PF00215
(OMPdecase) 		4 ILE A  77
GLY A  76
PHE A 100
CYH A  17
 None
 0.87A 5hieA-3qw3A:
undetectable		 5hieA-3qw3A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qw4 UMP SYNTHASE

(Leishmania
donovani) 		PF00156
(Pribosyltran)
PF00215
(OMPdecase) 		4 ILE B  77
GLY B  76
PHE B 100
CYH B  17
 None
 0.88A 5hieA-3qw4B:
undetectable		 5hieA-3qw4B:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sp1 CYSTEINYL-TRNA
SYNTHETASE

(Borreliella
burgdorferi) 		PF01406
(tRNA-synt_1e) 		4 ILE A  69
GLY A  70
CYH A 221
PHE A 105
 None
None
ZN  A 481 (-2.2A)
None
 1.13A 5hieA-3sp1A:
undetectable		 5hieA-3sp1A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t57 UDP-N-ACETYLGLUCOSAM
INE
O-ACYLTRANSFERASE
DOMAIN-CONTAINING
PROTEIN

(Arabidopsis
thaliana) 		PF00132
(Hexapep)
PF13720
(Acetyltransf_11) 		4 ILE A  65
GLY A  66
CYH A  75
PHE A 110
 None
 0.95A 5hieA-3t57A:
undetectable		 5hieA-3t57A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5o COMPLEMENT COMPONENT
C6

(Homo sapiens) 		PF00057
(Ldl_recept_a)
PF00084
(Sushi)
PF00090
(TSP_1)
PF01823
(MACPF) 		4 ILE A 282
PHE A 233
PHE A 360
ASP A 236
 None
 0.89A 5hieA-3t5oA:
undetectable		 5hieA-3t5oA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3td9 BRANCHED CHAIN AMINO
ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN

(Thermotoga
maritima) 		PF13458
(Peripla_BP_6) 		4 ILE A 249
GLY A 356
ASP A 359
PHE A 360
 EDO  A 407 (-4.6A)
None
None
None
 1.11A 5hieA-3td9A:
undetectable		 5hieA-3td9A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ti8 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 ILE A 106
GLY A 105
PHE A 446
PHE A 374
 None
 0.60A 5hieA-3ti8A:
undetectable		 5hieA-3ti8A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vpz GLUCOKINASE

(Pseudoalteromonas
sp. AS-131) 		PF02685
(Glucokinase) 		4 GLY A 171
PHE A 289
CYH A 155
PHE A 293
 None
 1.13A 5hieA-3vpzA:
undetectable		 5hieA-3vpzA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w3e COTYLEDONEOUS
YIELDIN-LIKE PROTEIN

(Vigna
unguiculata) 		PF00182
(Glyco_hydro_19) 		4 ILE A   7
GLY A   8
PHE A  29
ASP A  13
 None
 1.13A 5hieA-3w3eA:
undetectable		 5hieA-3w3eA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agu CYCLIN-DEPENDENT
KINASE-LIKE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A  10
GLY A  11
CYH A  83
PHE A 145
 D15  A 500 (-4.2A)
D15  A 500 (-3.8A)
D15  A 500 (-4.3A)
None
 0.79A 5hieA-4aguA:
23.8		 5hieA-4aguA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4btm TAU-TUBULIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A  64
GLY A  65
PHE A 117
PHE A 201
 F8E  A1340 (-4.8A)
F8E  A1340 ( 4.3A)
None
None
 0.82A 5hieA-4btmA:
4.0		 5hieA-4btmA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c22 L-FUCOSE ISOMERASE

(Streptococcus
pneumoniae) 		PF02952
(Fucose_iso_C)
PF07881
(Fucose_iso_N1)
PF07882
(Fucose_iso_N2) 		4 ILE A 189
GLY A 186
PHE A 332
PHE A 297
 None
 0.68A 5hieA-4c22A:
undetectable		 5hieA-4c22A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ep6 CYTOCHROME P450-LIKE
PROTEIN XPLA

(Rhodococcus
rhodochrous) 		PF00067
(p450) 		4 ILE A 396
GLY A 397
PHE A 540
PHE A 441
 HEM  A 601 (-3.9A)
None
None
HEM  A 601 (-4.4A)
 1.01A 5hieA-4ep6A:
undetectable		 5hieA-4ep6A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fem OUTER MEMBRANE
PROTEIN SUSE

(Bacteroides
thetaiotaomicron) 		PF16411
(SusF_SusE) 		4 ILE A 347
GLY A 382
PHE A 214
PHE A 263
 None
 1.14A 5hieA-4femA:
undetectable		 5hieA-4femA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iop C-TYPE LECTIN DOMAIN
FAMILY 2 MEMBER A

(Homo sapiens) 		PF00059
(Lectin_C) 		4 ILE A 161
GLY A 159
PHE A  72
PHE A  85
 None
 0.88A 5hieA-4iopA:
undetectable		 5hieA-4iopA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3j HEPATOCYTE GROWTH
FACTOR BETA CHAIN

(Homo sapiens) 		PF01403
(Sema)
PF01437
(PSI) 		4 ILE B  56
PHE B 261
PHE B 253
PHE B 196
 None
 1.02A 5hieA-4k3jB:
undetectable		 5hieA-4k3jB:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mdp BETA-GLUCOSIDASE

(Humicola grisea) 		PF00232
(Glyco_hydro_1) 		4 GLY A  28
PHE A 134
CYH A  36
ASP A 122
 None
 1.08A 5hieA-4mdpA:
undetectable		 5hieA-4mdpA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nfn TAU-TUBULIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLY A  41
PHE A  93
ASP A 176
PHE A 177
 2KC  A 401 ( 3.2A)
None
2KC  A 401 (-2.7A)
None
 0.77A 5hieA-4nfnA:
4.6		 5hieA-4nfnA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nfn TAU-TUBULIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A  40
GLY A  41
PHE A  93
ASP A 176
 2KC  A 401 ( 3.9A)
2KC  A 401 ( 3.2A)
None
2KC  A 401 (-2.7A)
 0.66A 5hieA-4nfnA:
4.6		 5hieA-4nfnA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qme AMINOPEPTIDASE N

(Neisseria
meningitidis) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		4 ILE A 861
GLY A 859
ASP A 813
PHE A 815
 None
 0.94A 5hieA-4qmeA:
undetectable		 5hieA-4qmeA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xb3 GLUCAN
1,6-ALPHA-GLUCOSIDAS
E

(Streptococcus
mutans) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 ILE A 396
GLY A 397
PHE A 158
ASP A 313
 None
 0.84A 5hieA-4xb3A:
undetectable		 5hieA-4xb3A:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE

(Bacillus
licheniformis) 		PF01019
(G_glu_transpept) 		4 ILE A 396
GLY A 397
PHE A  92
ASP A 441
 None
None
None
NA  A 601 (-3.3A)
 1.04A 5hieA-4y23A:
undetectable		 5hieA-4y23A:
18.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ILE A 469
GLY A 470
ASP A 606
PHE A 607
 4CV  A 801 (-4.3A)
4CV  A 801 ( 3.9A)
4CV  A 801 (-3.5A)
None
 0.87A 5hieA-4yffA:
25.5		 5hieA-4yffA:
31.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e66 HEMAGGLUTININ-ESTERA
SE

(Influenza D
virus) 		PF02710
(Hema_HEFG)
PF03996
(Hema_esterase) 		4 ILE A 257
GLY A 258
PHE A  93
PHE A 138
 None
 1.06A 5hieA-5e66A:
undetectable		 5hieA-5e66A:
19.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fd2 SERINE/THREONINE-PRO
TEIN KINASE B-RAF

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ILE A 463
GLY A 464
CYH A 532
PHE A 595
 5XJ  A 801 ( 4.7A)
None
5XJ  A 801 (-4.6A)
5XJ  A 801 (-3.7A)
 0.75A 5hieA-5fd2A:
35.6		 5hieA-5fd2A:
97.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fd2 SERINE/THREONINE-PRO
TEIN KINASE B-RAF

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ILE A 463
GLY A 464
PHE A 516
CYH A 532
 5XJ  A 801 ( 4.7A)
None
None
5XJ  A 801 (-4.6A)
 0.46A 5hieA-5fd2A:
35.6		 5hieA-5fd2A:
97.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g2v N-ACETYLGLUCOSAMINE-
6-SULFATASE

(Bacteroides
thetaiotaomicron) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		4 ILE A 123
GLY A 124
PHE A 102
CYH A 190
 None
 0.81A 5hieA-5g2vA:
undetectable		 5hieA-5g2vA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzt CHITINASE

(Paenibacillus
sp. FPU-7) 		PF00704
(Glyco_hydro_18) 		4 ILE B1410
GLY B1408
PHE B1342
ASP B1401
 None
 0.87A 5hieA-5gztB:
undetectable		 5hieA-5gztB:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzu CHITINASE

(Paenibacillus
sp. FPU-7) 		PF00704
(Glyco_hydro_18) 		4 ILE A1410
GLY A1408
PHE A1342
ASP A1401
 None
 0.89A 5hieA-5gzuA:
undetectable		 5hieA-5gzuA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ho4 HETEROGENEOUS
NUCLEAR
RIBONUCLEOPROTEINS
A2/B1

(Homo sapiens) 		PF00076
(RRM_1) 		4 ILE A  25
GLY A  65
PHE A  20
ASP A  49
 None
None
None
G  B   4 ( 2.9A)
 0.64A 5hieA-5ho4A:
undetectable		 5hieA-5ho4A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i84 PHOSPHATE-BINDING
PROTEIN PSTS

(Xanthomonas
citri) 		PF12849
(PBP_like_2) 		4 ILE A  66
GLY A  65
PHE A 263
ASP A  80
 PO4  A 404 (-4.2A)
None
None
None
 0.82A 5hieA-5i84A:
undetectable		 5hieA-5i84A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jsy PERIPLASMIC [NIFESE]
HYDROGENASE, SMALL
SUBUNIT

(Desulfovibrio
vulgaris) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		4 ILE A  58
GLY A  92
PHE A 143
ASP A 103
 None
 1.13A 5hieA-5jsyA:
undetectable		 5hieA-5jsyA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k47 POLYCYSTIN-2

(Homo sapiens) 		PF08016
(PKD_channel) 		4 GLY A 376
PHE A 436
ASP A 425
PHE A 426
 None
 1.12A 5hieA-5k47A:
undetectable		 5hieA-5k47A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8s CAMP-DEPENDENT
PROTEIN KINASE
REGULATORY SUBUNIT

(Plasmodium
falciparum) 		PF00027
(cNMP_binding) 		4 ILE A 351
GLY A 372
ASP A 354
PHE A 395
 None
 1.10A 5hieA-5k8sA:
undetectable		 5hieA-5k8sA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kod INDOLE-3-ACETIC
ACID-AMIDO
SYNTHETASE GH3.5

(Arabidopsis
thaliana) 		PF03321
(GH3) 		4 ILE A 541
GLY A 542
PHE A 500
ASP A 489
 None
 1.04A 5hieA-5kodA:
undetectable		 5hieA-5kodA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n0c TETANUS TOXIN

(Clostridium
tetani) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		4 ILE A 918
GLY A 917
ASP A1116
PHE A1305
 None
 1.09A 5hieA-5n0cA:
undetectable		 5hieA-5n0cA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o32 COMPLEMENT FACTOR
H,COMPLEMENT FACTOR
H
COMPLEMENT FACTOR I

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		4 ILE I 407
GLY C 122
PHE C 170
PHE C  93
 None
 0.77A 5hieA-5o32I:
undetectable		 5hieA-5o32I:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t7k AOAA13

(Aspergillus
oryzae) 		PF03067
(LPMO_10) 		4 GLY A   2
PHE A 218
ASP A  90
PHE A 166
 HIC  A   1 ( 2.3A)
None
None
None
 0.92A 5hieA-5t7kA:
undetectable		 5hieA-5t7kA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tr9 FERREDOXIN-NADP
REDUCTASE

(Neisseria
gonorrhoeae) 		PF00175
(NAD_binding_1) 		4 ILE A 132
GLY A 131
PHE A 148
PHE A 229
 None
 0.82A 5hieA-5tr9A:
undetectable		 5hieA-5tr9A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uhp O-GLCNACASE
TIM-BARREL DOMAIN

(Homo sapiens) 		PF07555
(NAGidase) 		4 ILE A 271
GLY A 238
PHE A 145
PHE A 191
 None
 1.07A 5hieA-5uhpA:
undetectable		 5hieA-5uhpA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uqc DIHYDROPYRIMIDINASE-
RELATED PROTEIN 2

(Mus musculus) 		PF01979
(Amidohydro_1) 		4 ILE A 447
GLY A 450
PHE A  90
ASP A 134
 None
 1.00A 5hieA-5uqcA:
undetectable		 5hieA-5uqcA:
19.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vo1 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 12

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 GLY A 134
CYH A 193
ASP A 254
PHE A 255
 9FS  A 501 ( 4.0A)
9FS  A 501 (-4.3A)
None
None
 1.08A 5hieA-5vo1A:
27.2		 5hieA-5vo1A:
34.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vo1 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 12

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 GLY A 137
CYH A 193
ASP A 254
PHE A 255
 None
9FS  A 501 (-4.3A)
None
None
 0.97A 5hieA-5vo1A:
27.2		 5hieA-5vo1A:
34.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7l N,N'-DIACETYLBACILLI
OSAMINYL-1-PHOSPHATE
TRANSFERASE

(Campylobacter
concisus) 		no annotation 4 ILE A 136
GLY A 135
ASP A 169
PHE A 166
 PG4  A 305 (-4.4A)
None
None
None
 0.78A 5hieA-5w7lA:
undetectable		 5hieA-5w7lA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
1

(Saccharomyces
cerevisiae) 		no annotation 4 GLY A 121
PHE A  43
PHE A  82
ASP A 127
 None
 1.11A 5hieA-5y58A:
undetectable		 5hieA-5y58A:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z43 AMBP1

(Fischerella
ambigua) 		no annotation 4 ILE A 160
GLY A 159
ASP A 108
PHE A  59
 None
 0.91A 5hieA-5z43A:
undetectable		 5hieA-5z43A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c6l V-TYPE PROTON ATPASE
SUBUNIT C'
V-TYPE PROTON ATPASE
SUBUNIT C''

(Saccharomyces
cerevisiae) 		no annotation 4 ILE D  43
GLY D  44
PHE C 106
PHE C 190
 None
 1.13A 5hieA-6c6lD:
undetectable		 5hieA-6c6lD:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6caa ELECTROGENIC SODIUM
BICARBONATE
COTRANSPORTER 1

(Homo sapiens) 		no annotation 4 ILE A 513
GLY A 514
PHE A 932
PHE A 752
 None
 1.14A 5hieA-6caaA:
undetectable		 5hieA-6caaA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ei3 PROTON-DEPENDENT
OLIGOPEPTIDE
TRANSPORTER FAMILY
PROTEIN

(Xanthomonas
campestris) 		no annotation 4 ILE A 399
GLY A 397
PHE A 423
PHE A 321
 78M  A 605 ( 4.9A)
None
None
None
 0.99A 5hieA-6ei3A:
1.3		 5hieA-6ei3A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eks SIALIDASE

(Vibrio cholerae) 		no annotation 4 ILE A 356
GLY A 355
PHE A 535
PHE A 466
 None
 1.08A 5hieA-6eksA:
undetectable		 5hieA-6eksA:
17.93