SIMILAR PATTERNS OF AMINO ACIDS FOR 5HI2_A_BAXA801_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5l UREASE (ALPHA
SUBUNIT)

(Klebsiella
aerogenes) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		5 ILE C  81
VAL C  82
VAL C  43
ILE C  51
ILE C 119
 None
 1.44A 5hi2A-1a5lC:
undetectable		 5hi2A-1a5lC:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5z L-LACTATE
DEHYDROGENASE

(Thermotoga
maritima) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 VAL A  32
ILE A  95
ILE A 250
ILE A 136
PHE A 149
 NAD  A 352 (-3.3A)
None
None
None
None
 1.17A 5hi2A-1a5zA:
undetectable		 5hi2A-1a5zA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a6d THERMOSOME (ALPHA
SUBUNIT)
THERMOSOME (BETA
SUBUNIT)

(Thermoplasma
acidophilum) 		PF00118
(Cpn60_TCP1) 		5 ILE A  55
VAL A  82
ILE A  34
ILE B 520
ASP A  72
 None
 1.17A 5hi2A-1a6dA:
2.6		 5hi2A-1a6dA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1air PECTATE LYASE C

(Dickeya
chrysanthemi) 		PF00544
(Pec_lyase_C) 		5 VAL A 340
VAL A 113
ILE A  54
ILE A  84
ILE A  29
 None
 1.31A 5hi2A-1airA:
undetectable		 5hi2A-1airA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1an7 RIBOSOMAL PROTEIN S8

(Thermus
thermophilus) 		PF00410
(Ribosomal_S8) 		5 VAL A  95
VAL A 137
ILE A  35
ILE A  83
ILE A   6
 None
 1.43A 5hi2A-1an7A:
undetectable		 5hi2A-1an7A:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dxe 2-DEHYDRO-3-DEOXY-GA
LACTARATE ALDOLASE

(Escherichia
coli) 		PF03328
(HpcH_HpaI) 		5 ILE A  21
VAL A  76
ILE A 148
ILE A  84
PHE A  10
 None
 1.34A 5hi2A-1dxeA:
undetectable		 5hi2A-1dxeA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e0t PYRUVATE KINASE

(Escherichia
coli) 		PF00224
(PK)
PF02887
(PK_C) 		5 ILE A 268
VAL A 189
ILE A 194
ILE A 203
ASP A 238
 None
 1.37A 5hi2A-1e0tA:
undetectable		 5hi2A-1e0tA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eep INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE

(Borreliella
burgdorferi) 		PF00478
(IMPDH) 		5 ILE A  60
VAL A  87
VAL A 158
ILE A 188
ILE A 198
 None
 1.29A 5hi2A-1eepA:
undetectable		 5hi2A-1eepA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f3g GLUCOSE-SPECIFIC
PHOSPHOCARRIER
PROTEIN IIAGLC

(Escherichia
coli) 		PF00358
(PTS_EIIA_1) 		5 ILE A 120
VAL A 119
ILE A 140
ILE A  20
ILE A 164
 None
 1.23A 5hi2A-1f3gA:
undetectable		 5hi2A-1f3gA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g0u PROTEASOME COMPONENT
PUP2

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		5 ILE D 196
VAL D 193
VAL D  68
ILE D 138
ILE D  89
 None
 1.44A 5hi2A-1g0uD:
undetectable		 5hi2A-1g0uD:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8w LEUCOAGGLUTINATING
PHYTOHEMAGGLUTININ

(Phaseolus
vulgaris) 		PF00139
(Lectin_legB) 		5 VAL A 205
VAL A 175
ILE A 138
ILE A 188
PHE A  72
 None
 1.38A 5hi2A-1g8wA:
undetectable		 5hi2A-1g8wA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hww ALPHA-MANNOSIDASE II

(Drosophila
melanogaster) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		5 ILE A 940
VAL A 580
ILE A 543
ILE A 618
ILE A 933
 None
 1.41A 5hi2A-1hwwA:
undetectable		 5hi2A-1hwwA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hyg L-LACTATE/MALATE
DEHYDROGENASE

(Methanocaldococcus
jannaschii) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ILE A 236
VAL A 239
VAL A 284
ILE A 175
ILE A 286
 None
 1.11A 5hi2A-1hygA:
undetectable		 5hi2A-1hygA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ig0 THIAMIN
PYROPHOSPHOKINASE

(Saccharomyces
cerevisiae) 		PF04263
(TPK_catalytic)
PF04265
(TPK_B1_binding) 		5 ILE A 134
VAL A 131
VAL A 200
ILE A 192
ILE A 227
 None
 1.16A 5hi2A-1ig0A:
undetectable		 5hi2A-1ig0A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ii8 RAD50 ABC-ATPASE

(Pyrococcus
furiosus) 		PF13304
(AAA_21)
PF13476
(AAA_23) 		5 ILE B 798
ILE B 851
ILE A  43
ILE A  28
ASP B 822
 None
 1.08A 5hi2A-1ii8B:
undetectable		 5hi2A-1ii8B:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ixp PYRIDOXINE
5'-PHOSPHATE
SYNTHASE

(Escherichia
coli) 		PF03740
(PdxJ) 		5 ILE A 203
VAL A 200
ILE A  10
ILE A  33
ILE A  42
 None
 1.14A 5hi2A-1ixpA:
undetectable		 5hi2A-1ixpA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j08 GLUTAREDOXIN-LIKE
PROTEIN

(Pyrococcus
horikoshii) 		PF00085
(Thioredoxin)
PF13192
(Thioredoxin_3) 		5 ILE A 111
VAL A 114
VAL A 136
ILE A 198
ILE A 140
 None
 1.48A 5hi2A-1j08A:
undetectable		 5hi2A-1j08A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j8m SIGNAL RECOGNITION
54 KDA PROTEIN

(Acidianus
ambivalens) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		5 ILE F 220
VAL F 136
ILE F 207
ILE F 168
ASP F 187
 None
 1.41A 5hi2A-1j8mF:
undetectable		 5hi2A-1j8mF:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jc9 TECHYLECTIN-5A

(Tachypleus
tridentatus) 		PF00147
(Fibrinogen_C) 		5 ILE A 195
ILE A  92
ILE A 141
ILE A 130
PHE A 192
 None
 1.41A 5hi2A-1jc9A:
undetectable		 5hi2A-1jc9A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k32 TRICORN PROTEASE

(Thermoplasma
acidophilum) 		PF03572
(Peptidase_S41)
PF07676
(PD40)
PF14684
(Tricorn_C1)
PF14685
(Tricorn_PDZ) 		5 VAL A 871
ILE A 956
ILE A1052
ILE A 983
ASP A 911
 None
 1.34A 5hi2A-1k32A:
undetectable		 5hi2A-1k32A:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1koa TWITCHIN

(Caenorhabditis
elegans) 		PF00069
(Pkinase)
PF07679
(I-set) 		5 ILE A5944
VAL A5959
ILE A5988
ILE A5933
ASP A6004
 None
 1.04A 5hi2A-1koaA:
22.3		 5hi2A-1koaA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l2q MONOMETHYLAMINE
METHYLTRANSFERASE

(Methanosarcina
barkeri) 		PF05369
(MtmB) 		5 ILE A 170
VAL A 230
ILE A 246
ILE A 214
ASP A 241
 None
 1.46A 5hi2A-1l2qA:
undetectable		 5hi2A-1l2qA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis) 		PF00478
(IMPDH) 		5 VAL A  55
VAL A 285
ILE A 238
ILE A 277
ILE A 260
 None
 1.42A 5hi2A-1lrtA:
undetectable		 5hi2A-1lrtA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lth L-LACTATE
DEHYDROGENASE (T-
AND R- STATE
TETRAMER COMPLEX)

(Bifidobacterium
longum) 		no annotation 4 VAL T 251
VAL T  36
ILE T  13
ILE T  72
 None
 0.61A 5hi2A-1lthT:
undetectable		 5hi2A-1lthT:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		4 VAL A 588
ILE A 637
ILE A 740
ASP A 742
 None
 0.47A 5hi2A-1lufA:
20.1		 5hi2A-1lufA:
29.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m53 ISOMALTULOSE
SYNTHASE

(Klebsiella sp.
LX3) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		5 ILE A 482
ILE A  92
ILE A 113
ILE A  75
ASP A  71
 None
 1.37A 5hi2A-1m53A:
undetectable		 5hi2A-1m53A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mk7 TALIN

(Gallus gallus) 		PF00373
(FERM_M)
PF02174
(IRS) 		5 ILE B 348
VAL B 347
ILE B 392
ILE B 399
ILE B 356
 None
 1.44A 5hi2A-1mk7B:
undetectable		 5hi2A-1mk7B:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mzh DEOXYRIBOSE-PHOSPHAT
E ALDOLASE

(Aquifex
aeolicus) 		PF01791
(DeoC) 		5 ILE A 276
VAL A 104
ILE A 284
ILE A 309
ASP A 109
 None
 1.34A 5hi2A-1mzhA:
undetectable		 5hi2A-1mzhA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nfg D-HYDANTOINASE

(Ralstonia
pickettii) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		5 ILE A 356
VAL A 351
ILE A 382
ILE A   5
ILE A  10
 None
 1.48A 5hi2A-1nfgA:
undetectable		 5hi2A-1nfgA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1noz DNA POLYMERASE

(Escherichia
virus T4) 		PF03104
(DNA_pol_B_exo1) 		5 ILE A 338
VAL A 145
ILE A 318
ILE A 323
ASP A 112
 None
 1.41A 5hi2A-1nozA:
undetectable		 5hi2A-1nozA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ocx MALTOSE
O-ACETYLTRANSFERASE

(Escherichia
coli) 		PF12464
(Mac)
PF14602
(Hexapep_2) 		5 ILE A  49
VAL A  91
ILE A  94
ILE A 108
PHE A  66
 None
 1.43A 5hi2A-1ocxA:
undetectable		 5hi2A-1ocxA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1olx 2-OXOISOVALERATE
DEHYDROGENASE BETA
SUBUNIT

(Homo sapiens) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 VAL B 162
VAL B 231
ILE B 234
ILE B 277
PHE B 287
 None
 1.47A 5hi2A-1olxB:
undetectable		 5hi2A-1olxB:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1omo ALANINE
DEHYDROGENASE

(Archaeoglobus
fulgidus) 		PF02423
(OCD_Mu_crystall) 		5 ILE A 175
VAL A 207
ILE A 285
ASP A 189
PHE A 128
 ILE  A 175 ( 0.6A)
VAL  A 207 ( 0.6A)
ILE  A 285 ( 0.7A)
ASP  A 189 ( 0.6A)
PHE  A 128 ( 1.3A)
 1.49A 5hi2A-1omoA:
undetectable		 5hi2A-1omoA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1onf GLUTATHIONE
REDUCTASE

(Plasmodium
falciparum) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ILE A  59
ILE A 191
ILE A 210
ILE A 231
ASP A 225
 None
 1.47A 5hi2A-1onfA:
undetectable		 5hi2A-1onfA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5d P450 EPOXIDASE

(Sorangium
cellulosum) 		PF00067
(p450) 		5 ILE A 251
VAL A 146
ILE A 406
ILE A 300
ASP A 257
 HEM  A 440 (-4.5A)
None
None
None
None
 1.34A 5hi2A-1q5dA:
undetectable		 5hi2A-1q5dA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8y SR PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		5 VAL A 172
ILE A 225
ILE A 290
ILE A 548
ASP A 550
 ADP  A 810 (-4.1A)
None
None
None
ADP  A 810 ( 3.0A)
 0.90A 5hi2A-1q8yA:
21.0		 5hi2A-1q8yA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qc5 PROTEIN (ALPHA1
BETA1 INTEGRIN)

(Homo sapiens) 		PF00092
(VWA) 		5 ILE B 471
VAL B 395
ILE B 335
ILE B 364
PHE B 354
 None
 1.49A 5hi2A-1qc5B:
undetectable		 5hi2A-1qc5B:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qs1 ADP-RIBOSYLTRANSFERA
SE

(Bacillus cereus) 		PF03496
(ADPrib_exo_Tox) 		5 ILE A 143
VAL A 207
ILE A 129
ILE A 224
ASP A 189
 None
 1.19A 5hi2A-1qs1A:
undetectable		 5hi2A-1qs1A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 624
ILE A 674
ILE A 827
ASP A 829
 None
 0.61A 5hi2A-1rjbA:
27.7		 5hi2A-1rjbA:
27.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sfj 3-DEHYDROQUINATE
DEHYDRATASE

(Staphylococcus
aureus) 		PF01487
(DHquinase_I) 		5 VAL A  49
ILE A 101
ILE A  38
ILE A  89
ASP A  91
 None
 1.15A 5hi2A-1sfjA:
undetectable		 5hi2A-1sfjA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sr4 CYTOLETHAL
DISTENDING TOXIN
PROTEIN B

([Haemophilus]
ducreyi) 		PF03372
(Exo_endo_phos) 		5 ILE B 224
VAL B 123
ILE B 149
ILE B 151
ASP B  60
 None
 1.37A 5hi2A-1sr4B:
undetectable		 5hi2A-1sr4B:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 37 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF08542
(Rep_fac_C) 		5 ILE B 235
VAL B 236
ILE B 195
ILE B 194
PHE B 225
 None
 1.16A 5hi2A-1sxjB:
3.3		 5hi2A-1sxjB:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szn ALPHA-GALACTOSIDASE

(Trichoderma
reesei) 		PF16499
(Melibiase_2) 		5 ILE A 227
ILE A  95
ILE A  68
ILE A  53
ASP A  55
 None
None
None
None
GOL  A 900 (-3.7A)
 1.09A 5hi2A-1sznA:
undetectable		 5hi2A-1sznA:
20.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 603
VAL A 643
ILE A 653
ILE A 808
ASP A 810
 STI  A   3 ( 4.6A)
None
None
None
STI  A   3 (-3.9A)
 0.71A 5hi2A-1t46A:
18.8		 5hi2A-1t46A:
30.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t8b PHOSPHATE TRANSPORT
SYSTEM PROTEIN PHOU
HOMOLOG

(Aquifex
aeolicus) 		PF01895
(PhoU) 		5 ILE A  63
VAL A  49
ILE A  31
ILE A 197
ASP A  99
 None
 1.46A 5hi2A-1t8bA:
2.2		 5hi2A-1t8bA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t8b PHOSPHATE TRANSPORT
SYSTEM PROTEIN PHOU
HOMOLOG

(Aquifex
aeolicus) 		PF01895
(PhoU) 		5 ILE A 129
VAL A 130
VAL A  91
ILE A  63
ILE A  21
 None
 1.46A 5hi2A-1t8bA:
2.2		 5hi2A-1t8bA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tnu GERANYLGERANYL
TRANSFERASE TYPE I
BETA SUBUNIT

(Rattus
norvegicus) 		PF00432
(Prenyltrans) 		5 ILE B 133
VAL B  26
ILE B 326
ILE B 337
ASP B  62
 None
 1.21A 5hi2A-1tnuB:
undetectable		 5hi2A-1tnuB:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqx D-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE,
PUTATIVE

(Plasmodium
falciparum) 		PF00834
(Ribul_P_3_epim) 		5 ILE A 139
ILE A   8
ILE A 204
ILE A 198
ASP A 179
 None
None
None
None
ZN  A 900 (-3.0A)
 1.41A 5hi2A-1tqxA:
undetectable		 5hi2A-1tqxA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1twl INORGANIC
PYROPHOSPHATASE

(Pyrococcus
furiosus) 		PF00719
(Pyrophosphatase) 		5 ILE A 167
VAL A  54
ILE A 133
ASP A  71
PHE A  70
 None
 1.42A 5hi2A-1twlA:
undetectable		 5hi2A-1twlA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2v ACTIN-RELATED
PROTEIN 3

(Bos taurus) 		PF00022
(Actin) 		5 ILE A 186
VAL A 180
ILE A 296
ILE A 193
ASP A 169
 None
 1.49A 5hi2A-1u2vA:
undetectable		 5hi2A-1u2vA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6c ALKALINE SERINE
PROTEASE

(Pseudoalteromonas
sp. AS-11) 		PF00082
(Peptidase_S8)
PF02225
(PA) 		5 VAL A  82
VAL A 375
ILE A  26
ILE A 154
ILE A  28
 CA  A 503 (-4.9A)
None
None
None
None
 1.30A 5hi2A-1v6cA:
undetectable		 5hi2A-1v6cA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vlj NADH-DEPENDENT
BUTANOL
DEHYDROGENASE

(Thermotoga
maritima) 		PF00465
(Fe-ADH) 		5 VAL A  84
VAL A  52
ILE A  61
ILE A  22
ILE A  31
 None
 1.50A 5hi2A-1vljA:
undetectable		 5hi2A-1vljA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w0h 3'-5' EXONUCLEASE
ERI1

(Homo sapiens) 		PF00929
(RNase_T) 		5 ILE A 152
ILE A 132
ILE A 166
ILE A 302
ASP A 297
 None
 1.42A 5hi2A-1w0hA:
undetectable		 5hi2A-1w0hA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wl8 GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG] SUBUNIT A

(Pyrococcus
horikoshii) 		PF00117
(GATase) 		5 ILE A  29
VAL A 124
ILE A 178
ILE A 106
ILE A 114
 None
None
None
None
SNN  A 112 ( 4.2A)
 1.31A 5hi2A-1wl8A:
undetectable		 5hi2A-1wl8A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xcf TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Escherichia
coli) 		PF00290
(Trp_syntA) 		5 ILE A 224
VAL A 220
VAL A  23
ILE A  37
ILE A  95
 None
 1.33A 5hi2A-1xcfA:
undetectable		 5hi2A-1xcfA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xi6 EXTRAGENIC
SUPPRESSOR

(Pyrococcus
furiosus) 		PF00459
(Inositol_P) 		5 ILE A  93
ILE A  13
ILE A 115
ILE A  54
ASP A  84
 None
 1.41A 5hi2A-1xi6A:
undetectable		 5hi2A-1xi6A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y9a NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Entamoeba
histolytica) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ILE A 140
VAL A 183
ILE A 206
ILE A 175
ILE A 345
 None
 1.46A 5hi2A-1y9aA:
undetectable		 5hi2A-1y9aA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yrw PROTEIN ARNA

(Escherichia
coli) 		PF00551
(Formyl_trans_N)
PF02911
(Formyl_trans_C) 		5 ILE A 144
VAL A 145
VAL A   4
ILE A  88
ILE A  71
 None
 1.24A 5hi2A-1yrwA:
undetectable		 5hi2A-1yrwA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yx2 AMINOMETHYLTRANSFERA
SE

(Bacillus
subtilis) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		5 ILE A 197
VAL A  57
ILE A 112
ILE A 134
ILE A 117
 None
 1.47A 5hi2A-1yx2A:
undetectable		 5hi2A-1yx2A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z26 ARGONAUTE

(Pyrococcus
furiosus) 		PF02171
(Piwi)
PF12212
(PAZ_siRNAbind) 		5 VAL A 661
VAL A  92
ILE A 101
ILE A  16
ILE A 312
 None
 1.30A 5hi2A-1z26A:
undetectable		 5hi2A-1z26A:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z68 FIBROBLAST
ACTIVATION PROTEIN,
ALPHA SUBUNIT

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		5 ILE A 339
ILE A 390
ILE A 429
ILE A 377
PHE A 368
 None
 1.48A 5hi2A-1z68A:
undetectable		 5hi2A-1z68A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7e PROTEIN ARNA

(Escherichia
coli) 		PF00551
(Formyl_trans_N)
PF01370
(Epimerase)
PF02911
(Formyl_trans_C) 		5 ILE A 144
VAL A 145
VAL A   4
ILE A  88
ILE A  71
 None
 1.24A 5hi2A-1z7eA:
undetectable		 5hi2A-1z7eA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbh 3'-5' EXONUCLEASE
ERI1

(Homo sapiens) 		PF00929
(RNase_T)
PF02037
(SAP) 		5 ILE A 152
ILE A 132
ILE A 166
ILE A 302
ASP A 297
 None
 1.45A 5hi2A-1zbhA:
undetectable		 5hi2A-1zbhA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zdr DIHYDROFOLATE
REDUCTASE

(Geobacillus
stearothermophilus) 		PF00186
(DHFR_1) 		5 ILE A 137
VAL A 138
ILE A  95
ILE A  86
ASP A 110
 None
 1.23A 5hi2A-1zdrA:
undetectable		 5hi2A-1zdrA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zjy R-SPECIFIC ALCOHOL
DEHYDROGENASE

(Lactobacillus
brevis) 		PF13561
(adh_short_C2) 		5 VAL A  87
ILE A  35
ILE A  22
ILE A  56
PHE A  80
 None
 1.04A 5hi2A-1zjyA:
undetectable		 5hi2A-1zjyA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zrz PROTEIN KINASE C,
IOTA

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		5 ILE A 251
VAL A 259
VAL A 296
ILE A 365
ASP A 387
 BI1  A1000 (-3.9A)
BI1  A1000 (-4.2A)
None
None
BI1  A1000 (-4.5A)
 0.95A 5hi2A-1zrzA:
22.4		 5hi2A-1zrzA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b1p MITOGEN-ACTIVATED
PROTEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A  70
VAL A  78
ILE A 123
ILE A 185
ILE A 205
 AIZ  A 501 ( 4.5A)
AIZ  A 501 ( 4.7A)
None
None
None
 1.08A 5hi2A-2b1pA:
19.1		 5hi2A-2b1pA:
26.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btw ALR0975 PROTEIN

(Nostoc sp. PCC
7120) 		PF05023
(Phytochelatin) 		5 ILE A 149
VAL A 139
ILE A 168
ILE A 132
ILE A 184
 None
 1.17A 5hi2A-2btwA:
undetectable		 5hi2A-2btwA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1h DELTA-AMINOLEVULINIC
ACID DEHYDRATASE

(Prosthecochloris
vibrioformis) 		PF00490
(ALAD) 		5 ILE A  81
VAL A  37
VAL A 271
ILE A 243
ILE A 194
 None
 1.16A 5hi2A-2c1hA:
undetectable		 5hi2A-2c1hA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2czd OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Pyrococcus
horikoshii) 		PF00215
(OMPdecase) 		5 ILE A  25
VAL A   3
ILE A  70
ILE A  35
ASP A  57
 None
None
None
None
DTT  A 501 ( 4.4A)
 1.50A 5hi2A-2czdA:
undetectable		 5hi2A-2czdA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2de0 ALPHA-(1,6)-FUCOSYLT
RANSFERASE

(Homo sapiens) 		PF14604
(SH3_9) 		5 VAL X 359
VAL X 474
ILE X 451
ASP X 453
PHE X 456
 None
 1.39A 5hi2A-2de0X:
undetectable		 5hi2A-2de0X:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7y TRNASE Z

(Thermotoga
maritima) 		PF12706
(Lactamase_B_2) 		5 VAL A  86
VAL A 127
ILE A 187
ILE A 145
ILE A  15
 None
 1.18A 5hi2A-2e7yA:
undetectable		 5hi2A-2e7yA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE

(Methanocaldococcus
jannaschii) 		PF01368
(DHH)
PF02833
(DHHA2) 		5 ILE A  63
VAL A   4
VAL A  42
ILE A 183
ILE A 144
 None
 1.39A 5hi2A-2eb0A:
undetectable		 5hi2A-2eb0A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f4z TGTWINSCAN_2721 - E2
DOMAIN

(Toxoplasma
gondii) 		PF00179
(UQ_con) 		5 ILE A  69
VAL A  70
ILE A 151
ILE A 117
ILE A  81
 None
 1.33A 5hi2A-2f4zA:
undetectable		 5hi2A-2f4zA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f4z TGTWINSCAN_2721 - E2
DOMAIN

(Toxoplasma
gondii) 		PF00179
(UQ_con) 		5 ILE A  69
VAL A  70
ILE A 151
ILE A 122
ILE A  81
 None
 1.40A 5hi2A-2f4zA:
undetectable		 5hi2A-2f4zA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g1s RENIN

(Homo sapiens) 		PF00026
(Asp) 		5 ILE A 329
ILE A 138
ILE A  19
ILE A 142
PHE A 153
 None
 1.38A 5hi2A-2g1sA:
undetectable		 5hi2A-2g1sA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g1s RENIN

(Homo sapiens) 		PF00026
(Asp) 		5 ILE A 329
VAL A  30
ILE A 138
ILE A  19
PHE A 153
 None
 1.20A 5hi2A-2g1sA:
undetectable		 5hi2A-2g1sA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gdz NAD+-DEPENDENT
15-HYDROXYPROSTAGLAN
DIN DEHYDROGENASE

(Homo sapiens) 		PF00106
(adh_short) 		5 VAL A  78
VAL A   3
ILE A 132
ILE A 230
ILE A 134
 None
 1.25A 5hi2A-2gdzA:
undetectable		 5hi2A-2gdzA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ge3 PROBABLE
ACETYLTRANSFERASE

(Agrobacterium
tumefaciens) 		PF00583
(Acetyltransf_1) 		5 ILE A  54
VAL A  50
VAL A  28
ILE A  93
ILE A  70
 None
None
None
ACO  A1301 (-4.0A)
None
 1.49A 5hi2A-2ge3A:
undetectable		 5hi2A-2ge3A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gfq UPF0204 PROTEIN
PH0006

(Pyrococcus
horikoshii) 		PF04414
(tRNA_deacylase) 		5 ILE A 113
VAL A 226
ILE A 195
ILE A 245
PHE A 238
 None
 1.32A 5hi2A-2gfqA:
undetectable		 5hi2A-2gfqA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gup ROK FAMILY PROTEIN

(Streptococcus
pneumoniae) 		PF00480
(ROK) 		5 ILE A 177
VAL A 176
VAL A 244
ILE A 123
ILE A 127
 None
 1.39A 5hi2A-2gupA:
undetectable		 5hi2A-2gupA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwg 4-OXALOMESACONATE
HYDRATASE

(Rhodopseudomonas
palustris) 		PF04909
(Amidohydro_2) 		5 VAL A  67
ILE A 255
ILE A 274
ILE A 221
ASP A 258
 None
 1.21A 5hi2A-2gwgA:
undetectable		 5hi2A-2gwgA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwn DIHYDROOROTASE

(Porphyromonas
gingivalis) 		PF01979
(Amidohydro_1) 		5 ILE A  31
VAL A  21
VAL A  85
ILE A  60
ASP A 384
 None
 1.08A 5hi2A-2gwnA:
undetectable		 5hi2A-2gwnA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h0r NICOTINAMIDASE

(Saccharomyces
cerevisiae) 		PF00857
(Isochorismatase) 		5 ILE A  89
VAL A 160
ILE A  32
ILE A  14
ASP A   8
 None
 1.05A 5hi2A-2h0rA:
undetectable		 5hi2A-2h0rA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hae MALATE
OXIDOREDUCTASE

(Thermotoga
maritima) 		PF00390
(malic)
PF03949
(Malic_M) 		5 VAL A 204
VAL A 312
ILE A 355
ILE A 300
PHE A 254
 None
 1.32A 5hi2A-2haeA:
undetectable		 5hi2A-2haeA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hdi COLICIN I RECEPTOR

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 VAL A 114
VAL A 153
ILE A 133
ILE A 125
PHE A 120
 None
 1.08A 5hi2A-2hdiA:
undetectable		 5hi2A-2hdiA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hj0 PUTATIVE CITRATE
LYASE, ALFA SUBUNIT

(Streptococcus
mutans) 		PF04223
(CitF) 		5 ILE A 432
VAL A 383
VAL A 263
ILE A 369
ASP A 439
 None
 1.47A 5hi2A-2hj0A:
undetectable		 5hi2A-2hj0A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hw6 MAP
KINASE-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  63
ILE A 107
ILE A 166
ILE A 189
ASP A 191
 None
 1.24A 5hi2A-2hw6A:
22.2		 5hi2A-2hw6A:
27.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i5b PHOSPHOMETHYLPYRIMID
INE KINASE

(Bacillus
subtilis) 		PF08543
(Phos_pyr_kin) 		5 ILE A  88
VAL A 222
ILE A 236
ILE A 138
ASP A 107
 None
 1.45A 5hi2A-2i5bA:
undetectable		 5hi2A-2i5bA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ich PUTATIVE ATTH

(Nitrosomonas
europaea) 		PF07143
(CrtC)
PF17186
(Lipocalin_9) 		5 ILE A 102
ILE A  68
ILE A 147
ASP A 108
PHE A 152
 None
 1.25A 5hi2A-2ichA:
undetectable		 5hi2A-2ichA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j4l URIDYLATE KINASE

(Sulfolobus
solfataricus) 		PF00696
(AA_kinase) 		5 ILE A 189
VAL A 192
VAL A  37
ILE A  27
ILE A   7
 None
 1.39A 5hi2A-2j4lA:
undetectable		 5hi2A-2j4lA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jc6 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1D

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  37
ILE A  81
ILE A 140
ILE A 163
 QPP  A1314 ( 4.6A)
None
None
None
 0.61A 5hi2A-2jc6A:
22.9		 5hi2A-2jc6A:
27.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jda YECBM32

(Yersinia
enterocolitica) 		PF00754
(F5_F8_type_C) 		5 VAL A  13
ILE A 113
ILE A  10
ILE A  59
PHE A  73
 GOL  A1147 ( 4.8A)
None
None
None
None
 1.41A 5hi2A-2jdaA:
undetectable		 5hi2A-2jdaA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jeo URIDINE-CYTIDINE
KINASE 1

(Homo sapiens) 		PF00485
(PRK) 		5 ILE A 209
VAL A 135
ILE A 104
ILE A 148
PHE A 143
 None
 1.40A 5hi2A-2jeoA:
undetectable		 5hi2A-2jeoA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kbs HARMONIN

(Homo sapiens) 		PF00595
(PDZ) 		5 ILE A  32
VAL A  62
ILE A  27
ILE A  87
ILE A  39
 None
 1.50A 5hi2A-2kbsA:
undetectable		 5hi2A-2kbsA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ke7 ANKYRIN REPEAT AND
STERILE ALPHA MOTIF
DOMAIN-CONTAINING
PROTEIN 1B

(Homo sapiens) 		PF00536
(SAM_1) 		5 VAL A 847
ILE A 856
ILE A 871
ILE A 858
ASP A 850
 None
 1.50A 5hi2A-2ke7A:
undetectable		 5hi2A-2ke7A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mh8 GA-79-MBP, MALTOSE
BINDING PROTEIN

(Streptococcus
dysgalactiae) 		PF17573
(GA-like) 		5 VAL A  42
ILE A  49
ILE A  33
ILE A  25
ASP A  19
 None
 1.18A 5hi2A-2mh8A:
undetectable		 5hi2A-2mh8A:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nly DIVERGENT
POLYSACCHARIDE
DEACETYLASE
HYPOTHETICAL PROTEIN

(Bacillus
halodurans) 		PF04748
(Polysacc_deac_2) 		5 VAL A 221
ILE A 232
ILE A  38
ILE A  56
ASP A  50
 None
 1.46A 5hi2A-2nlyA:
undetectable		 5hi2A-2nlyA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzu CATABOLITE CONTROL
PROTEIN

(Bacillus
megaterium) 		PF13377
(Peripla_BP_3) 		5 ILE G 272
VAL G 290
ILE G 148
ILE G 318
ASP G 160
 None
None
None
None
SO4  G 945 ( 4.2A)
 1.42A 5hi2A-2nzuG:
undetectable		 5hi2A-2nzuG:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3j UDP-GLUCOSE
6-DEHYDROGENASE

(Caenorhabditis
elegans) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		5 ILE A 458
VAL A 373
ILE A 338
ILE A 361
ILE A 325
 None
 1.27A 5hi2A-2o3jA:
undetectable		 5hi2A-2o3jA:
21.38