SIMILAR PATTERNS OF AMINO ACIDS FOR 5HI2_A_BAXA801

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4l CELL DIVISION
PROTEIN KINASE 5

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  31
LYS A  33
GLU A  51
LEU A  55
CYH A  83
HIS A 124
 None
 0.87A 5hi2A-1h4lA:
15.0		 5hi2A-1h4lA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 ALA A 220
LYS A 222
GLU A 236
THR A 266
LEU A 305
HIS A 312
 None
 0.67A 5hi2A-1k9aA:
27.9		 5hi2A-1k9aA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 ALA A 288
LYS A 290
GLU A 305
THR A 334
LEU A 373
HIS A 380
 P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-3.7A)
None
None
 0.55A 5hi2A-1opkA:
26.4		 5hi2A-1opkA:
19.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1py5 TGF-BETA RECEPTOR
TYPE I

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		6 ALA A 230
LYS A 232
GLU A 245
LEU A 260
LEU A 316
HIS A 331
 PY1  A 700 (-3.5A)
PY1  A 700 (-3.9A)
PY1  A 700 ( 4.9A)
PY1  A 700 (-4.2A)
None
None
 0.59A 5hi2A-1py5A:
25.6		 5hi2A-1py5A:
30.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8y SR PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		6 ALA A 185
LYS A 187
GLU A 202
LEU A 206
LEU A 226
HIS A 292
 ADP  A 810 (-3.3A)
ADP  A 810 (-3.1A)
None
None
ADP  A 810 (-4.4A)
None
 0.82A 5hi2A-1q8yA:
21.0		 5hi2A-1q8yA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 642
LYS A 644
GLU A 661
CYH A 694
LEU A 802
HIS A 809
 None
 0.76A 5hi2A-1rjbA:
27.7		 5hi2A-1rjbA:
27.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 621
LYS A 623
GLU A 640
LEU A 644
THR A 670
CYH A 673
LEU A 783
HIS A 790
 STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 (-4.4A)
STI  A   3 (-3.2A)
STI  A   3 (-4.5A)
None
STI  A   3 (-4.5A)
 0.64A 5hi2A-1t46A:
18.8		 5hi2A-1t46A:
30.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		8 ALA A  55
LYS A  57
GLU A  76
LEU A  80
CYH A 108
LEU A 142
HIS A 149
GLY A 168
 None
 0.73A 5hi2A-1u5qA:
24.4		 5hi2A-1u5qA:
30.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  36
LYS A  38
GLU A  55
CYH A  87
LEU A 121
HIS A 128
 HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
None
HYM  A 400 (-4.2A)
None
None
 0.69A 5hi2A-1zltA:
21.7		 5hi2A-1zltA:
26.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zws DAP-KINASE RELATED
PROTEIN 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  40
LYS A  42
GLU A  64
LEU A  68
LEU A 130
HIS A 137
 None
 0.71A 5hi2A-1zwsA:
24.9		 5hi2A-1zwsA:
27.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  40
LYS A  42
GLU A  64
LEU A  68
LEU A 130
HIS A 137
 GOL  A3001 (-3.5A)
None
None
None
None
None
 0.64A 5hi2A-2a2aA:
24.3		 5hi2A-2a2aA:
26.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 184
LYS A 186
GLU A 201
LEU A 205
LEU A 274
HIS A 281
 None
 0.74A 5hi2A-2eu9A:
22.8		 5hi2A-2eu9A:
24.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		7 ALA A  55
LYS A  57
GLU A  76
CYH A 108
LEU A 142
HIS A 149
GLY A 168
 STU  A 400 (-3.2A)
STU  A 400 ( 4.5A)
None
STU  A 400 (-4.0A)
None
None
None
 0.76A 5hi2A-2gcdA:
25.4		 5hi2A-2gcdA:
30.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		7 ALA A  55
LYS A  57
GLU A  76
LEU A  80
LEU A 142
HIS A 149
GLY A 168
 STU  A 400 (-3.2A)
STU  A 400 ( 4.5A)
None
None
None
None
None
 0.87A 5hi2A-2gcdA:
25.4		 5hi2A-2gcdA:
30.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		7 ALA A 452
LYS A 454
GLU A 471
CYH A 502
LEU A 537
HIS A 544
GLY A 563
 4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 ( 4.6A)
4ST  A1687 (-4.1A)
None
None
None
 0.50A 5hi2A-2j0jA:
28.4		 5hi2A-2j0jA:
17.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		7 ALA A 452
LYS A 454
GLU A 471
CYH A 502
LEU A 537
HIS A 544
GLY A 563
 BII  A1687 (-3.5A)
BII  A1687 (-2.9A)
None
BII  A1687 (-4.1A)
None
None
BII  A1687 ( 3.9A)
 0.65A 5hi2A-2jkmA:
16.5		 5hi2A-2jkmA:
30.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 614
GLU A 633
THR A 663
CYH A 666
LEU A 769
HIS A 776
GLY A 795
 None
 0.49A 5hi2A-2ogvA:
26.7		 5hi2A-2ogvA:
28.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 614
LYS A 616
GLU A 633
THR A 663
LEU A 769
HIS A 776
GLY A 795
 None
 0.73A 5hi2A-2ogvA:
26.7		 5hi2A-2ogvA:
28.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 215
LYS A 217
GLU A 230
LEU A 245
THR A 265
LEU A 301
 ADE  A 488 (-3.2A)
None
None
ADE  A 488 ( 4.5A)
ADE  A 488 (-4.3A)
None
 0.84A 5hi2A-2qluA:
25.5		 5hi2A-2qluA:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 215
LYS A 217
LEU A 245
THR A 265
LEU A 301
HIS A 319
 ADE  A 488 (-3.2A)
None
ADE  A 488 ( 4.5A)
ADE  A 488 (-4.3A)
None
None
 0.73A 5hi2A-2qluA:
25.5		 5hi2A-2qluA:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qr7 RIBOSOMAL PROTEIN S6
KINASE ALPHA-3

(Mus musculus) 		PF00069
(Pkinase) 		7 ALA A 449
LYS A 451
GLU A 463
LEU A 467
THR A 493
LEU A 530
HIS A 537
 None
 0.70A 5hi2A-2qr7A:
20.9		 5hi2A-2qr7A:
25.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  40
LYS A  42
GLU A  64
LEU A  68
LEU A 130
HIS A 137
 ADP  A1303 (-3.5A)
ADP  A1303 (-2.7A)
ADP  A1303 ( 4.8A)
None
None
None
 0.59A 5hi2A-2w4kA:
24.3		 5hi2A-2w4kA:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnt RIBOSOMAL PROTEIN S6
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 LYS A 447
GLU A 459
LEU A 463
THR A 489
LEU A 526
HIS A 533
 None
 0.86A 5hi2A-2wntA:
20.7		 5hi2A-2wntA:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yab DEATH-ASSOCIATED
PROTEIN KINASE 2

(Mus musculus) 		PF00069
(Pkinase) 		6 ALA A  40
LYS A  42
GLU A  64
LEU A  68
LEU A 130
HIS A 137
 AMP  A1302 (-3.6A)
AMP  A1302 (-2.8A)
None
None
None
None
 0.59A 5hi2A-2yabA:
24.5		 5hi2A-2yabA:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2w WEE1-LIKE PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 326
LYS A 328
GLU A 346
CYH A 379
HIS A 424
GLY A 462
 770  A 901 (-3.5A)
770  A 901 (-4.6A)
770  A 901 (-3.9A)
770  A 901 (-3.9A)
None
None
 0.90A 5hi2A-2z2wA:
23.5		 5hi2A-2z2wA:
28.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqr DEATH-ASSOCIATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  40
LYS A  42
GLU A  64
LEU A  68
LEU A 130
HIS A 137
 4RB  A 401 (-3.3A)
4RB  A 401 ( 2.8A)
GOL  A 503 (-2.8A)
None
None
None
 0.70A 5hi2A-3bqrA:
23.2		 5hi2A-3bqrA:
28.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 220
LYS A 222
GLU A 236
THR A 266
LEU A 305
HIS A 312
 None
 0.67A 5hi2A-3d7uA:
19.9		 5hi2A-3d7uA:
31.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7o MITOGEN-ACTIVATED
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  53
LYS A  55
GLU A  73
LEU A  77
LEU A 142
HIS A 149
 35F  A   1 (-3.6A)
35F  A   1 ( 4.6A)
None
None
None
None
 0.75A 5hi2A-3e7oA:
20.1		 5hi2A-3e7oA:
27.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 859
LYS A 861
GLU A 878
LEU A 882
CYH A 912
LEU A1013
HIS A1020
 8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
8ST  A2001 (-3.7A)
None
8ST  A2001 (-3.8A)
8ST  A2001 (-4.6A)
8ST  A2001 ( 4.8A)
 0.53A 5hi2A-3hngA:
28.3		 5hi2A-3hngA:
27.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		6 ALA A 665
LYS A 667
GLU A 684
THR A 713
LEU A 751
HIS A 758
 None
 0.73A 5hi2A-3kulA:
20.1		 5hi2A-3kulA:
32.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		7 ALA A 700
LYS A 702
GLU A 715
LEU A 719
CYH A 748
LEU A 788
HIS A 795
 ADP  A2101 (-3.5A)
ADP  A2101 (-2.7A)
None
None
ADP  A2101 (-4.2A)
None
None
 0.76A 5hi2A-3lj0A:
23.8		 5hi2A-3lj0A:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llt SERINE/THREONINE
KINASE-1, PFLAMMER

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		6 ALA A 579
LYS A 581
GLU A 596
LEU A 600
LEU A 668
HIS A 675
 ANP  A 877 ( 3.7A)
ANP  A 877 (-2.7A)
ANP  A 877 ( 4.4A)
None
None
None
 0.74A 5hi2A-3lltA:
21.5		 5hi2A-3lltA:
26.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		7 ALA A 229
LYS A 231
GLU A 244
LEU A 259
THR A 279
LEU A 315
HIS A 330
 LDN  A   1 (-3.6A)
None
None
None
LDN  A   1 (-3.8A)
None
None
 0.70A 5hi2A-3mdyA:
25.3		 5hi2A-3mdyA:
31.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mi9 CELL DIVISION
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  46
LYS A  48
GLU A  66
LEU A  70
CYH A 106
HIS A 147
 None
 0.70A 5hi2A-3mi9A:
14.9		 5hi2A-3mi9A:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 227
LYS A 229
LEU A 257
THR A 277
LEU A 313
HIS A 328
 LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
None
LDN  A 600 (-4.0A)
None
None
 0.72A 5hi2A-3my0A:
24.9		 5hi2A-3my0A:
28.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 ALA A 373
LYS A 375
GLU A 393
LEU A 397
LEU A 406
THR A 421
TRP A 423
CYH A 424
LEU A 459
GLY A 485
 SM5  A   1 (-3.6A)
SM5  A   1 (-3.5A)
SM5  A   1 (-4.3A)
None
None
SM5  A   1 (-4.4A)
SM5  A   1 (-4.3A)
SM5  A   1 ( 4.4A)
None
None
 0.95A 5hi2A-3omvA:
33.4		 5hi2A-3omvA:
71.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 ALA A 373
LYS A 375
LEU A 397
LEU A 406
THR A 421
TRP A 423
CYH A 424
LEU A 459
HIS A 466
GLY A 485
 SM5  A   1 (-3.6A)
SM5  A   1 (-3.5A)
None
None
SM5  A   1 (-4.4A)
SM5  A   1 (-4.3A)
SM5  A   1 ( 4.4A)
None
None
None
 0.82A 5hi2A-3omvA:
33.4		 5hi2A-3omvA:
71.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pg1 MITOGEN-ACTIVATED
PROTEIN KINASE,
PUTATIVE (MAP
KINASE-LIKE PROTEIN)

(Leishmania
major) 		PF00069
(Pkinase) 		6 ALA A  49
LEU A  82
LEU A  91
THR A 112
LEU A 149
HIS A 156
 None
 0.72A 5hi2A-3pg1A:
6.1		 5hi2A-3pg1A:
25.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3q4t ACTIVIN RECEPTOR
TYPE-2A

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 217
LYS A 219
LEU A 247
THR A 267
LEU A 303
HIS A 320
 TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
None
TAK  A   2 (-3.5A)
None
None
 0.86A 5hi2A-3q4tA:
25.1		 5hi2A-3q4tA:
30.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		7 ALA A  84
LYS A  86
GLU A 115
LEU A 119
THR A 144
LEU A 181
HIS A 188
 ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
None
None
ANP  A1634 (-4.6A)
None
None
 0.82A 5hi2A-3q5iA:
21.7		 5hi2A-3q5iA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		6 ALA B 616
LYS B 618
GLU B 635
LEU B 639
CYH B 889
GLY B 952
 None
 0.75A 5hi2A-3qd2B:
22.2		 5hi2A-3qd2B:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		6 ALA B 616
LYS B 618
LEU B 639
CYH B 889
HIS B 933
GLY B 952
 None
 0.82A 5hi2A-3qd2B:
22.2		 5hi2A-3qd2B:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s95 LIM DOMAIN KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LYS A 368
GLU A 384
LEU A 397
THR A 413
LEU A 451
HIS A 458
 STU  A   1 (-3.1A)
STU  A   1 (-3.7A)
STU  A   1 (-4.6A)
STU  A   1 (-3.9A)
None
None
 0.62A 5hi2A-3s95A:
25.7		 5hi2A-3s95A:
29.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 866
LYS A 868
GLU A 885
LEU A 889
CYH A 919
LEU A1019
HIS A1026
 4TT  A2001 (-3.5A)
None
None
None
4TT  A2001 (-4.3A)
None
None
 0.67A 5hi2A-3vidA:
27.3		 5hi2A-3vidA:
26.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 866
LYS A 868
GLU A 885
LEU A 889
CYH A 919
LEU A1019
HIS A1026
 LEV  A1201 (-3.5A)
None
LEV  A1201 (-3.7A)
LEV  A1201 ( 4.4A)
LEV  A1201 (-4.1A)
None
None
 0.64A 5hi2A-3wzdA:
27.4		 5hi2A-3wzdA:
29.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A1978
LYS A1980
LEU A2010
LEU A2070
HIS A2077
GLY A2101
 VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
VGH  A3000 (-4.8A)
None
None
VGH  A3000 (-3.5A)
 0.78A 5hi2A-3zbfA:
19.6		 5hi2A-3zbfA:
31.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  31
LYS A  33
GLU A  50
LEU A  54
LEU A 116
HIS A 123
 38R  A 350 (-3.4A)
38R  A 350 (-2.9A)
38R  A 350 ( 4.8A)
None
None
None
 0.90A 5hi2A-3zduA:
23.1		 5hi2A-3zduA:
28.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  80
LYS A  82
GLU A 101
CYH A 133
LEU A 167
HIS A 174
GLY A 193
 939  A1331 (-3.5A)
939  A1331 (-2.6A)
None
939  A1331 (-4.0A)
None
None
None
 0.78A 5hi2A-4a4lA:
15.2		 5hi2A-4a4lA:
27.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 866
GLU A 885
LEU A 889
CYH A 919
LEU A1019
HIS A1026
 B49  A2000 (-3.5A)
None
None
B49  A2000 (-4.2A)
None
None
 0.66A 5hi2A-4agdA:
27.7		 5hi2A-4agdA:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agu CYCLIN-DEPENDENT
KINASE-LIKE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  31
LYS A  33
GLU A  51
LEU A  55
CYH A  83
HIS A 124
 D15  A 500 (-3.4A)
D15  A 500 ( 4.1A)
None
None
D15  A 500 (-4.3A)
None
 0.55A 5hi2A-4aguA:
24.6		 5hi2A-4aguA:
25.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 121
LYS A 123
GLU A 140
THR A 169
LEU A 207
HIS A 214
 30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
None
30K  A1365 (-3.8A)
None
None
 0.87A 5hi2A-4aw5A:
28.4		 5hi2A-4aw5A:
32.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  89
LYS A  91
GLU A 110
CYH A 142
LEU A 176
HIS A 183
GLY A 202
 9ZP  A1333 (-3.5A)
None
None
9ZP  A1333 (-4.1A)
None
None
9ZP  A1333 ( 4.4A)
 0.66A 5hi2A-4b6lA:
24.4		 5hi2A-4b6lA:
27.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  63
GLU A  81
LEU A  85
CYH A 113
LEU A 148
HIS A 155
 XZN  A1317 (-3.5A)
XZN  A1317 (-3.9A)
None
XZN  A1317 (-3.7A)
None
None
 0.74A 5hi2A-4bc6A:
21.9		 5hi2A-4bc6A:
27.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c02 ACTIVIN RECEPTOR
TYPE-1

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		6 ALA A 233
LYS A 235
LEU A 263
THR A 283
LEU A 319
HIS A 334
 TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
FLC  A1503 ( 4.5A)
TAK  A1507 (-3.6A)
None
None
 0.67A 5hi2A-4c02A:
24.9		 5hi2A-4c02A:
30.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 653
LYS A 655
GLU A 672
THR A 701
LEU A 757
HIS A 764
 DI1  A1000 (-3.6A)
DI1  A1000 (-3.9A)
DI1  A1000 (-3.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-4.4A)
DI1  A1000 (-3.8A)
 0.62A 5hi2A-4ckrA:
28.0		 5hi2A-4ckrA:
30.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  36
GLU A  55
LEU A  59
CYH A  89
LEU A 126
HIS A 133
 BX7  A 401 (-3.4A)
None
None
BX7  A 401 (-4.1A)
None
None
 0.73A 5hi2A-4eutA:
20.8		 5hi2A-4eutA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  36
LYS A  38
GLU A  55
LEU A  59
CYH A  89
LEU A 126
 BX7  A 401 (-3.4A)
BX7  A 401 ( 4.0A)
None
None
BX7  A 401 (-4.1A)
None
 0.66A 5hi2A-4eutA:
20.8		 5hi2A-4eutA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  36
GLU A  55
LEU A  59
CYH A  89
LEU A 126
HIS A 133
 BX7  A 401 (-3.4A)
None
None
BX7  A 401 (-4.1A)
None
None
 0.71A 5hi2A-4euuA:
14.5		 5hi2A-4euuA:
27.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  36
LYS A  38
GLU A  55
LEU A  59
CYH A  89
LEU A 126
 BX7  A 401 (-3.4A)
BX7  A 401 (-3.5A)
None
None
BX7  A 401 (-4.1A)
None
 0.59A 5hi2A-4euuA:
14.5		 5hi2A-4euuA:
27.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 ALA A 880
LYS A 882
GLU A 898
LEU A 902
LEU A 967
HIS A 974
GLY A 993
 IZA  A2001 (-3.4A)
IZA  A2001 ( 4.7A)
None
None
None
None
None
 0.97A 5hi2A-4gl9A:
25.5		 5hi2A-4gl9A:
31.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 853
LYS A 855
GLU A 871
LEU A 875
LEU A 940
HIS A 947
 19S  A1201 (-3.3A)
19S  A1201 (-3.5A)
None
None
None
None
 0.69A 5hi2A-4hviA:
26.9		 5hi2A-4hviA:
28.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzs ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14604
(SH3_9) 		6 ALA A 156
LYS A 158
THR A 205
LEU A 243
HIS A 250
GLY A 269
 None
 0.72A 5hi2A-4hzsA:
25.4		 5hi2A-4hzsA:
29.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 109
LYS A 111
GLU A 130
CYH A 162
LEU A 196
HIS A 203
GLY A 222
 1C7  A 401 (-3.2A)
1C7  A 401 ( 4.7A)
None
1C7  A 401 (-4.1A)
None
None
None
 0.70A 5hi2A-4i6fA:
22.7		 5hi2A-4i6fA:
27.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7b POLO-LIKE KINASE

(Danio rerio) 		PF00069
(Pkinase) 		6 ALA A  66
LYS A  68
CYH A 119
LEU A 153
HIS A 160
GLY A 179
 None
 0.46A 5hi2A-4j7bA:
24.0		 5hi2A-4j7bA:
27.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7b POLO-LIKE KINASE

(Danio rerio) 		PF00069
(Pkinase) 		6 LYS A  68
GLU A  87
CYH A 119
LEU A 153
HIS A 160
GLY A 179
 None
 0.82A 5hi2A-4j7bA:
24.0		 5hi2A-4j7bA:
27.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A  61
LYS A  63
GLU A  77
LEU A  81
LEU A 144
HIS A 154
 1UL  A 501 (-3.1A)
None
None
None
None
None
 0.78A 5hi2A-4l52A:
18.9		 5hi2A-4l52A:
31.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		6 ALA A  49
LYS A  51
LEU A  74
THR A  95
LEU A 132
HIS A 141
 ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
None
ANP  A 401 (-3.8A)
None
None
 0.79A 5hi2A-4m69A:
25.9		 5hi2A-4m69A:
27.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2

(Plasmodium
falciparum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		6 ALA A  99
LYS A 101
GLU A 117
CYH A 149
LEU A 183
HIS A 190
 STU  A 601 (-3.3A)
STU  A 601 (-3.9A)
None
STU  A 601 (-4.2A)
None
None
 0.78A 5hi2A-4mvfA:
21.7		 5hi2A-4mvfA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA B  51
LYS B  53
GLU B  70
LEU B  74
LEU B 135
HIS B 142
 ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
None
None
None
None
 0.59A 5hi2A-4o27B:
16.4		 5hi2A-4o27B:
28.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  67
LYS A  69
GLU A  85
THR A 123
CYH A 126
HIS A 171
 SIN  A 401 ( 3.7A)
None
None
None
SIN  A 401 (-4.3A)
None
 0.67A 5hi2A-4o38A:
21.2		 5hi2A-4o38A:
26.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 642
LYS A 644
GLU A 661
CYH A 694
LEU A 802
HIS A 809
 P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
None
P30  A1001 ( 4.3A)
 0.52A 5hi2A-4rt7A:
19.1		 5hi2A-4rt7A:
25.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		6 ALA A  35
LYS A  37
GLU A  52
THR A  81
LEU A 120
HIS A 127
 ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
None
None
 0.81A 5hi2A-4ueuA:
28.5		 5hi2A-4ueuA:
36.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 642
LYS A 644
GLU A 661
CYH A 694
LEU A 802
HIS A 809
 P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
P30  A1001 (-4.2A)
None
P30  A1001 (-4.4A)
 0.49A 5hi2A-4xufA:
27.6		 5hi2A-4xufA:
29.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 488
GLU A 509
LEU A 513
THR A 539
LEU A 577
HIS A 586
 4CV  A 801 (-3.5A)
None
None
4CV  A 801 (-2.8A)
None
None
 0.72A 5hi2A-4yffA:
26.7		 5hi2A-4yffA:
31.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 488
LYS A 490
GLU A 509
LEU A 513
THR A 539
LEU A 577
 4CV  A 801 (-3.5A)
4CV  A 801 (-3.9A)
None
None
4CV  A 801 (-2.8A)
None
 0.49A 5hi2A-4yffA:
26.7		 5hi2A-4yffA:
31.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		6 ALA A  55
LYS A  57
GLU A  76
LEU A  80
THR A 105
HIS A 149
 ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
None
ADP  A 506 ( 4.6A)
None
 0.80A 5hi2A-4ysjA:
25.1		 5hi2A-4ysjA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Homo sapiens) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		6 ALA A 597
GLU A 612
LEU A 616
CYH A 645
LEU A 679
HIS A 686
 None
 0.72A 5hi2A-4z7gA:
21.4		 5hi2A-4z7gA:
25.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  52
LYS A  54
GLU A  69
LEU A  73
LEU A 144
HIS A 151
 ALA  A  52 (-0.0A)
LYS  A  54 ( 0.0A)
GLU  A  69 ( 0.6A)
LEU  A  73 ( 0.6A)
LEU  A 144 ( 0.6A)
HIS  A 151 ( 1.0A)
 0.92A 5hi2A-5d7aA:
24.7		 5hi2A-5d7aA:
31.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8y TGF-BETA RECEPTOR
TYPE-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 275
LYS A 277
GLU A 290
LEU A 305
THR A 325
LEU A 361
 STU  A 601 (-3.1A)
STU  A 601 (-2.4A)
STU  A 601 ( 3.8A)
STU  A 601 ( 3.8A)
STU  A 601 ( 3.7A)
None
 0.81A 5hi2A-5e8yA:
25.3		 5hi2A-5e8yA:
27.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8y TGF-BETA RECEPTOR
TYPE-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 275
LYS A 277
LEU A 305
THR A 325
LEU A 361
HIS A 377
 STU  A 601 (-3.1A)
STU  A 601 (-2.4A)
STU  A 601 ( 3.8A)
STU  A 601 ( 3.7A)
None
None
 0.75A 5hi2A-5e8yA:
25.3		 5hi2A-5e8yA:
27.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 928
LYS A 930
GLU A 947
LEU A 951
LEU A1014
HIS A1021
GLY A1040
 5U3  A1200 (-3.5A)
None
None
None
None
None
5U3  A1200 ( 4.9A)
 1.02A 5hi2A-5f1zA:
25.7		 5hi2A-5f1zA:
29.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fd2 SERINE/THREONINE-PRO
TEIN KINASE B-RAF

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ALA A 481
LYS A 483
LEU A 514
THR A 529
TRP A 531
CYH A 532
LEU A 567
HIS A 574
GLY A 593
 5XJ  A 801 (-3.1A)
5XJ  A 801 (-3.8A)
5XJ  A 801 (-4.5A)
5XJ  A 801 (-3.4A)
5XJ  A 801 (-4.4A)
5XJ  A 801 (-4.6A)
None
None
5XJ  A 801 ( 3.7A)
 0.59A 5hi2A-5fd2A:
25.2		 5hi2A-5fd2A:
89.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 756
LYS A 758
GLU A 775
LEU A 779
LEU A 865
HIS A 872
 PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
PP1  A2012 (-3.5A)
None
None
None
 0.75A 5hi2A-5fm2A:
27.4		 5hi2A-5fm2A:
28.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 625
LYS A 627
GLU A 644
THR A 674
CYH A 677
LEU A 809
HIS A 816
 748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.2A)
748  A1001 (-4.5A)
748  A1001 ( 4.6A)
748  A1001 (-3.8A)
 0.56A 5hi2A-5grnA:
18.6		 5hi2A-5grnA:
27.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idn CYCLIN-DEPENDENT
KINASE 8

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  50
LYS A  52
GLU A  66
LEU A  70
LEU A 142
HIS A 149
 6A7  A 401 (-3.3A)
6A7  A 401 ( 2.9A)
FMT  A 404 ( 4.2A)
None
None
FMT  A 403 (-4.6A)
 0.83A 5hi2A-5idnA:
12.4		 5hi2A-5idnA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  43
LYS A  45
GLU A  61
CYH A  93
LEU A 127
HIS A 134
 6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
TPO  A 145 (-4.1A)
None
None
 0.62A 5hi2A-5j5tA:
21.6		 5hi2A-5j5tA:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 417
GLU A 436
LEU A 440
LEU A 502
HIS A 509
GLY A 532
 GUI  A 701 ( 3.9A)
None
None
None
None
GUI  A 701 ( 4.7A)
 0.85A 5hi2A-5jznA:
23.9		 5hi2A-5jznA:
27.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ko1 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 228
LYS A 230
GLU A 250
LEU A 263
CYH A 286
LEU A 320
HIS A 329
 6UY  A 501 (-3.4A)
6UY  A 501 (-4.0A)
6UY  A 501 (-4.3A)
None
6UY  A 501 (-4.3A)
None
None
 0.86A 5hi2A-5ko1A:
26.5		 5hi2A-5ko1A:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 176
LYS A 178
GLU A 193
LEU A 197
LEU A 266
HIS A 273
 7A7  A 501 (-3.5A)
7A7  A 501 (-3.5A)
7A7  A 501 ( 4.7A)
None
None
None
 0.92A 5hi2A-5lxdA:
20.7		 5hi2A-5lxdA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo sapiens) 		no annotation 6 ALA A  38
LYS A  40
GLU A  57
LEU A  61
CYH A  89
HIS A 130
 7LV  A 401 (-3.4A)
7LV  A 401 (-3.0A)
7LV  A 401 (-3.5A)
None
7LV  A 401 (-4.3A)
None
 0.73A 5hi2A-5tvtA:
23.6		 5hi2A-5tvtA:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 137
GLU A 157
THR A 187
CYH A 190
LEU A 224
HIS A 231
GLY A 250
 H8H  A 401 (-3.3A)
None
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
None
None
None
 0.71A 5hi2A-5vcxA:
22.3		 5hi2A-5vcxA:
26.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 137
LYS A 139
GLU A 157
THR A 187
CYH A 190
HIS A 231
GLY A 250
 H8H  A 401 (-3.3A)
H8H  A 401 (-4.9A)
None
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
None
None
 0.80A 5hi2A-5vcxA:
22.3		 5hi2A-5vcxA:
26.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 6 ALA A 917
LYS A 919
LEU A 947
THR A 963
LEU A1001
HIS A1008
 ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
ANP  A1201 (-4.7A)
ANP  A1201 (-3.9A)
None
None
 0.85A 5hi2A-5wnoA:
25.0		 5hi2A-5wnoA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1

(Homo sapiens) 		no annotation 6 ALA A 107
LYS A 109
GLU A 124
LEU A 128
LEU A 203
HIS A 211
 EMH  A 705 (-3.6A)
EMH  A 705 ( 4.8A)
None
None
None
None
 0.68A 5hi2A-5xv7A:
21.2		 5hi2A-5xv7A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 7 ALA A 906
LYS A 908
GLU A 925
LEU A 929
LEU A 994
HIS A1001
GLY A1020
 ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
None
None
None
None
 0.93A 5hi2A-6c7yA:
25.6		 5hi2A-6c7yA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG

(Homo sapiens) 		no annotation 6 ALA A 715
LYS A 717
GLU A 732
LEU A 736
LEU A 751
HIS A 813
 919  A1101 (-3.5A)
SO4  A1102 ( 2.8A)
919  A1101 (-3.7A)
None
919  A1101 (-4.5A)
919  A1101 (-4.2A)
 0.61A 5hi2A-6cnhA:
21.4		 5hi2A-6cnhA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG

(Homo sapiens) 		no annotation 6 LYS A 717
GLU A 732
LEU A 736
LEU A 751
LEU A 806
HIS A 813
 SO4  A1102 ( 2.8A)
919  A1101 (-3.7A)
None
919  A1101 (-4.5A)
None
919  A1101 (-4.2A)
 0.61A 5hi2A-6cnhA:
21.4		 5hi2A-6cnhA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cz4 PROTEIN-TYROSINE
KINASE 6

(Homo sapiens) 		no annotation 6 ALA A 217
LEU A 248
THR A 264
LEU A 303
HIS A 310
GLY A 329
 FKY  A9001 (-3.3A)
FKY  A9001 (-4.2A)
FKY  A9001 (-3.0A)
FKY  A9001 (-4.4A)
FKY  A9001 (-3.9A)
FKY  A9001 (-3.4A)
 0.51A 5hi2A-6cz4A:
27.7		 5hi2A-6cz4A:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyl DUAL SPECIFICITY
PROTEIN KINASE CLK2

(Homo sapiens) 		no annotation 6 ALA A 191
LYS A 193
GLU A 208
LEU A 212
LEU A 281
HIS A 288
 3NG  A 501 (-3.3A)
3NG  A 501 (-3.0A)
3NG  A 501 ( 4.9A)
None
None
None
 0.63A 5hi2A-6fylA:
22.6		 5hi2A-6fylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4

(Homo sapiens) 		no annotation 6 ALA A 189
LYS A 191
GLU A 206
LEU A 210
LEU A 279
HIS A 286
 3NG  A 501 (-3.5A)
3NG  A 501 (-2.7A)
3NG  A 501 ( 4.7A)
None
None
None
 0.77A 5hi2A-6fyvA:
22.5		 5hi2A-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5l UREASE (ALPHA
SUBUNIT)

(Klebsiella
aerogenes) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		5 ILE C  81
VAL C  82
VAL C  43
ILE C  51
ILE C 119
 None
 1.44A 5hi2A-1a5lC:
undetectable		 5hi2A-1a5lC:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5z L-LACTATE
DEHYDROGENASE

(Thermotoga
maritima) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 VAL A  32
ILE A  95
ILE A 250
ILE A 136
PHE A 149
 NAD  A 352 (-3.3A)
None
None
None
None
 1.17A 5hi2A-1a5zA:
undetectable		 5hi2A-1a5zA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a6d THERMOSOME (ALPHA
SUBUNIT)
THERMOSOME (BETA
SUBUNIT)

(Thermoplasma
acidophilum) 		PF00118
(Cpn60_TCP1) 		5 ILE A  55
VAL A  82
ILE A  34
ILE B 520
ASP A  72
 None
 1.17A 5hi2A-1a6dA:
2.6		 5hi2A-1a6dA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1air PECTATE LYASE C

(Dickeya
chrysanthemi) 		PF00544
(Pec_lyase_C) 		5 VAL A 340
VAL A 113
ILE A  54
ILE A  84
ILE A  29
 None
 1.31A 5hi2A-1airA:
undetectable		 5hi2A-1airA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1an7 RIBOSOMAL PROTEIN S8

(Thermus
thermophilus) 		PF00410
(Ribosomal_S8) 		5 VAL A  95
VAL A 137
ILE A  35
ILE A  83
ILE A   6
 None
 1.43A 5hi2A-1an7A:
undetectable		 5hi2A-1an7A:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dxe 2-DEHYDRO-3-DEOXY-GA
LACTARATE ALDOLASE

(Escherichia
coli) 		PF03328
(HpcH_HpaI) 		5 ILE A  21
VAL A  76
ILE A 148
ILE A  84
PHE A  10
 None
 1.34A 5hi2A-1dxeA:
undetectable		 5hi2A-1dxeA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e0t PYRUVATE KINASE

(Escherichia
coli) 		PF00224
(PK)
PF02887
(PK_C) 		5 ILE A 268
VAL A 189
ILE A 194
ILE A 203
ASP A 238
 None
 1.37A 5hi2A-1e0tA:
undetectable		 5hi2A-1e0tA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eep INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE

(Borreliella
burgdorferi) 		PF00478
(IMPDH) 		5 ILE A  60
VAL A  87
VAL A 158
ILE A 188
ILE A 198
 None
 1.29A 5hi2A-1eepA:
undetectable		 5hi2A-1eepA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f3g GLUCOSE-SPECIFIC
PHOSPHOCARRIER
PROTEIN IIAGLC

(Escherichia
coli) 		PF00358
(PTS_EIIA_1) 		5 ILE A 120
VAL A 119
ILE A 140
ILE A  20
ILE A 164
 None
 1.23A 5hi2A-1f3gA:
undetectable		 5hi2A-1f3gA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g0u PROTEASOME COMPONENT
PUP2

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		5 ILE D 196
VAL D 193
VAL D  68
ILE D 138
ILE D  89
 None
 1.44A 5hi2A-1g0uD:
undetectable		 5hi2A-1g0uD:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8w LEUCOAGGLUTINATING
PHYTOHEMAGGLUTININ

(Phaseolus
vulgaris) 		PF00139
(Lectin_legB) 		5 VAL A 205
VAL A 175
ILE A 138
ILE A 188
PHE A  72
 None
 1.38A 5hi2A-1g8wA:
undetectable		 5hi2A-1g8wA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hww ALPHA-MANNOSIDASE II

(Drosophila
melanogaster) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		5 ILE A 940
VAL A 580
ILE A 543
ILE A 618
ILE A 933
 None
 1.41A 5hi2A-1hwwA:
undetectable		 5hi2A-1hwwA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hyg L-LACTATE/MALATE
DEHYDROGENASE

(Methanocaldococcus
jannaschii) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ILE A 236
VAL A 239
VAL A 284
ILE A 175
ILE A 286
 None
 1.11A 5hi2A-1hygA:
undetectable		 5hi2A-1hygA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ig0 THIAMIN
PYROPHOSPHOKINASE

(Saccharomyces
cerevisiae) 		PF04263
(TPK_catalytic)
PF04265
(TPK_B1_binding) 		5 ILE A 134
VAL A 131
VAL A 200
ILE A 192
ILE A 227
 None
 1.16A 5hi2A-1ig0A:
undetectable		 5hi2A-1ig0A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ii8 RAD50 ABC-ATPASE

(Pyrococcus
furiosus) 		PF13304
(AAA_21)
PF13476
(AAA_23) 		5 ILE B 798
ILE B 851
ILE A  43
ILE A  28
ASP B 822
 None
 1.08A 5hi2A-1ii8B:
undetectable		 5hi2A-1ii8B:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ixp PYRIDOXINE
5'-PHOSPHATE
SYNTHASE

(Escherichia
coli) 		PF03740
(PdxJ) 		5 ILE A 203
VAL A 200
ILE A  10
ILE A  33
ILE A  42
 None
 1.14A 5hi2A-1ixpA:
undetectable		 5hi2A-1ixpA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j08 GLUTAREDOXIN-LIKE
PROTEIN

(Pyrococcus
horikoshii) 		PF00085
(Thioredoxin)
PF13192
(Thioredoxin_3) 		5 ILE A 111
VAL A 114
VAL A 136
ILE A 198
ILE A 140
 None
 1.48A 5hi2A-1j08A:
undetectable		 5hi2A-1j08A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j8m SIGNAL RECOGNITION
54 KDA PROTEIN

(Acidianus
ambivalens) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		5 ILE F 220
VAL F 136
ILE F 207
ILE F 168
ASP F 187
 None
 1.41A 5hi2A-1j8mF:
undetectable		 5hi2A-1j8mF:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jc9 TECHYLECTIN-5A

(Tachypleus
tridentatus) 		PF00147
(Fibrinogen_C) 		5 ILE A 195
ILE A  92
ILE A 141
ILE A 130
PHE A 192
 None
 1.41A 5hi2A-1jc9A:
undetectable		 5hi2A-1jc9A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k32 TRICORN PROTEASE

(Thermoplasma
acidophilum) 		PF03572
(Peptidase_S41)
PF07676
(PD40)
PF14684
(Tricorn_C1)
PF14685
(Tricorn_PDZ) 		5 VAL A 871
ILE A 956
ILE A1052
ILE A 983
ASP A 911
 None
 1.34A 5hi2A-1k32A:
undetectable		 5hi2A-1k32A:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1koa TWITCHIN

(Caenorhabditis
elegans) 		PF00069
(Pkinase)
PF07679
(I-set) 		5 ILE A5944
VAL A5959
ILE A5988
ILE A5933
ASP A6004
 None
 1.04A 5hi2A-1koaA:
22.3		 5hi2A-1koaA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l2q MONOMETHYLAMINE
METHYLTRANSFERASE

(Methanosarcina
barkeri) 		PF05369
(MtmB) 		5 ILE A 170
VAL A 230
ILE A 246
ILE A 214
ASP A 241
 None
 1.46A 5hi2A-1l2qA:
undetectable		 5hi2A-1l2qA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis) 		PF00478
(IMPDH) 		5 VAL A  55
VAL A 285
ILE A 238
ILE A 277
ILE A 260
 None
 1.42A 5hi2A-1lrtA:
undetectable		 5hi2A-1lrtA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lth L-LACTATE
DEHYDROGENASE (T-
AND R- STATE
TETRAMER COMPLEX)

(Bifidobacterium
longum) 		no annotation 4 VAL T 251
VAL T  36
ILE T  13
ILE T  72
 None
 0.61A 5hi2A-1lthT:
undetectable		 5hi2A-1lthT:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		4 VAL A 588
ILE A 637
ILE A 740
ASP A 742
 None
 0.47A 5hi2A-1lufA:
20.1		 5hi2A-1lufA:
29.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m53 ISOMALTULOSE
SYNTHASE

(Klebsiella sp.
LX3) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		5 ILE A 482
ILE A  92
ILE A 113
ILE A  75
ASP A  71
 None
 1.37A 5hi2A-1m53A:
undetectable		 5hi2A-1m53A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mk7 TALIN

(Gallus gallus) 		PF00373
(FERM_M)
PF02174
(IRS) 		5 ILE B 348
VAL B 347
ILE B 392
ILE B 399
ILE B 356
 None
 1.44A 5hi2A-1mk7B:
undetectable		 5hi2A-1mk7B:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mzh DEOXYRIBOSE-PHOSPHAT
E ALDOLASE

(Aquifex
aeolicus) 		PF01791
(DeoC) 		5 ILE A 276
VAL A 104
ILE A 284
ILE A 309
ASP A 109
 None
 1.34A 5hi2A-1mzhA:
undetectable		 5hi2A-1mzhA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nfg D-HYDANTOINASE

(Ralstonia
pickettii) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		5 ILE A 356
VAL A 351
ILE A 382
ILE A   5
ILE A  10
 None
 1.48A 5hi2A-1nfgA:
undetectable		 5hi2A-1nfgA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1noz DNA POLYMERASE

(Escherichia
virus T4) 		PF03104
(DNA_pol_B_exo1) 		5 ILE A 338
VAL A 145
ILE A 318
ILE A 323
ASP A 112
 None
 1.41A 5hi2A-1nozA:
undetectable		 5hi2A-1nozA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ocx MALTOSE
O-ACETYLTRANSFERASE

(Escherichia
coli) 		PF12464
(Mac)
PF14602
(Hexapep_2) 		5 ILE A  49
VAL A  91
ILE A  94
ILE A 108
PHE A  66
 None
 1.43A 5hi2A-1ocxA:
undetectable		 5hi2A-1ocxA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1olx 2-OXOISOVALERATE
DEHYDROGENASE BETA
SUBUNIT

(Homo sapiens) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 VAL B 162
VAL B 231
ILE B 234
ILE B 277
PHE B 287
 None
 1.47A 5hi2A-1olxB:
undetectable		 5hi2A-1olxB:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1omo ALANINE
DEHYDROGENASE

(Archaeoglobus
fulgidus) 		PF02423
(OCD_Mu_crystall) 		5 ILE A 175
VAL A 207
ILE A 285
ASP A 189
PHE A 128
 ILE  A 175 ( 0.6A)
VAL  A 207 ( 0.6A)
ILE  A 285 ( 0.7A)
ASP  A 189 ( 0.6A)
PHE  A 128 ( 1.3A)
 1.49A 5hi2A-1omoA:
undetectable		 5hi2A-1omoA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1onf GLUTATHIONE
REDUCTASE

(Plasmodium
falciparum) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ILE A  59
ILE A 191
ILE A 210
ILE A 231
ASP A 225
 None
 1.47A 5hi2A-1onfA:
undetectable		 5hi2A-1onfA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5d P450 EPOXIDASE

(Sorangium
cellulosum) 		PF00067
(p450) 		5 ILE A 251
VAL A 146
ILE A 406
ILE A 300
ASP A 257
 HEM  A 440 (-4.5A)
None
None
None
None
 1.34A 5hi2A-1q5dA:
undetectable		 5hi2A-1q5dA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8y SR PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		5 VAL A 172
ILE A 225
ILE A 290
ILE A 548
ASP A 550
 ADP  A 810 (-4.1A)
None
None
None
ADP  A 810 ( 3.0A)
 0.90A 5hi2A-1q8yA:
21.0		 5hi2A-1q8yA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qc5 PROTEIN (ALPHA1
BETA1 INTEGRIN)

(Homo sapiens) 		PF00092
(VWA) 		5 ILE B 471
VAL B 395
ILE B 335
ILE B 364
PHE B 354
 None
 1.49A 5hi2A-1qc5B:
undetectable		 5hi2A-1qc5B:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qs1 ADP-RIBOSYLTRANSFERA
SE

(Bacillus cereus) 		PF03496
(ADPrib_exo_Tox) 		5 ILE A 143
VAL A 207
ILE A 129
ILE A 224
ASP A 189
 None
 1.19A 5hi2A-1qs1A:
undetectable		 5hi2A-1qs1A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 624
ILE A 674
ILE A 827
ASP A 829
 None
 0.61A 5hi2A-1rjbA:
27.7		 5hi2A-1rjbA:
27.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sfj 3-DEHYDROQUINATE
DEHYDRATASE

(Staphylococcus
aureus) 		PF01487
(DHquinase_I) 		5 VAL A  49
ILE A 101
ILE A  38
ILE A  89
ASP A  91
 None
 1.15A 5hi2A-1sfjA:
undetectable		 5hi2A-1sfjA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sr4 CYTOLETHAL
DISTENDING TOXIN
PROTEIN B

([Haemophilus]
ducreyi) 		PF03372
(Exo_endo_phos) 		5 ILE B 224
VAL B 123
ILE B 149
ILE B 151
ASP B  60
 None
 1.37A 5hi2A-1sr4B:
undetectable		 5hi2A-1sr4B:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 37 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF08542
(Rep_fac_C) 		5 ILE B 235
VAL B 236
ILE B 195
ILE B 194
PHE B 225
 None
 1.16A 5hi2A-1sxjB:
3.3		 5hi2A-1sxjB:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szn ALPHA-GALACTOSIDASE

(Trichoderma
reesei) 		PF16499
(Melibiase_2) 		5 ILE A 227
ILE A  95
ILE A  68
ILE A  53
ASP A  55
 None
None
None
None
GOL  A 900 (-3.7A)
 1.09A 5hi2A-1sznA:
undetectable		 5hi2A-1sznA:
20.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 603
VAL A 643
ILE A 653
ILE A 808
ASP A 810
 STI  A   3 ( 4.6A)
None
None
None
STI  A   3 (-3.9A)
 0.71A 5hi2A-1t46A:
18.8		 5hi2A-1t46A:
30.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t8b PHOSPHATE TRANSPORT
SYSTEM PROTEIN PHOU
HOMOLOG

(Aquifex
aeolicus) 		PF01895
(PhoU) 		5 ILE A  63
VAL A  49
ILE A  31
ILE A 197
ASP A  99
 None
 1.46A 5hi2A-1t8bA:
2.2		 5hi2A-1t8bA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t8b PHOSPHATE TRANSPORT
SYSTEM PROTEIN PHOU
HOMOLOG

(Aquifex
aeolicus) 		PF01895
(PhoU) 		5 ILE A 129
VAL A 130
VAL A  91
ILE A  63
ILE A  21
 None
 1.46A 5hi2A-1t8bA:
2.2		 5hi2A-1t8bA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tnu GERANYLGERANYL
TRANSFERASE TYPE I
BETA SUBUNIT

(Rattus
norvegicus) 		PF00432
(Prenyltrans) 		5 ILE B 133
VAL B  26
ILE B 326
ILE B 337
ASP B  62
 None
 1.21A 5hi2A-1tnuB:
undetectable		 5hi2A-1tnuB:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqx D-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE,
PUTATIVE

(Plasmodium
falciparum) 		PF00834
(Ribul_P_3_epim) 		5 ILE A 139
ILE A   8
ILE A 204
ILE A 198
ASP A 179
 None
None
None
None
ZN  A 900 (-3.0A)
 1.41A 5hi2A-1tqxA:
undetectable		 5hi2A-1tqxA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1twl INORGANIC
PYROPHOSPHATASE

(Pyrococcus
furiosus) 		PF00719
(Pyrophosphatase) 		5 ILE A 167
VAL A  54
ILE A 133
ASP A  71
PHE A  70
 None
 1.42A 5hi2A-1twlA:
undetectable		 5hi2A-1twlA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2v ACTIN-RELATED
PROTEIN 3

(Bos taurus) 		PF00022
(Actin) 		5 ILE A 186
VAL A 180
ILE A 296
ILE A 193
ASP A 169
 None
 1.49A 5hi2A-1u2vA:
undetectable		 5hi2A-1u2vA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6c ALKALINE SERINE
PROTEASE

(Pseudoalteromonas
sp. AS-11) 		PF00082
(Peptidase_S8)
PF02225
(PA) 		5 VAL A  82
VAL A 375
ILE A  26
ILE A 154
ILE A  28
 CA  A 503 (-4.9A)
None
None
None
None
 1.30A 5hi2A-1v6cA:
undetectable		 5hi2A-1v6cA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vlj NADH-DEPENDENT
BUTANOL
DEHYDROGENASE

(Thermotoga
maritima) 		PF00465
(Fe-ADH) 		5 VAL A  84
VAL A  52
ILE A  61
ILE A  22
ILE A  31
 None
 1.50A 5hi2A-1vljA:
undetectable		 5hi2A-1vljA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w0h 3'-5' EXONUCLEASE
ERI1

(Homo sapiens) 		PF00929
(RNase_T) 		5 ILE A 152
ILE A 132
ILE A 166
ILE A 302
ASP A 297
 None
 1.42A 5hi2A-1w0hA:
undetectable		 5hi2A-1w0hA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wl8 GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG] SUBUNIT A

(Pyrococcus
horikoshii) 		PF00117
(GATase) 		5 ILE A  29
VAL A 124
ILE A 178
ILE A 106
ILE A 114
 None
None
None
None
SNN  A 112 ( 4.2A)
 1.31A 5hi2A-1wl8A:
undetectable		 5hi2A-1wl8A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xcf TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Escherichia
coli) 		PF00290
(Trp_syntA) 		5 ILE A 224
VAL A 220
VAL A  23
ILE A  37
ILE A  95
 None
 1.33A 5hi2A-1xcfA:
undetectable		 5hi2A-1xcfA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xi6 EXTRAGENIC
SUPPRESSOR

(Pyrococcus
furiosus) 		PF00459
(Inositol_P) 		5 ILE A  93
ILE A  13
ILE A 115
ILE A  54
ASP A  84
 None
 1.41A 5hi2A-1xi6A:
undetectable		 5hi2A-1xi6A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y9a NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Entamoeba
histolytica) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ILE A 140
VAL A 183
ILE A 206
ILE A 175
ILE A 345
 None
 1.46A 5hi2A-1y9aA:
undetectable		 5hi2A-1y9aA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yrw PROTEIN ARNA

(Escherichia
coli) 		PF00551
(Formyl_trans_N)
PF02911
(Formyl_trans_C) 		5 ILE A 144
VAL A 145
VAL A   4
ILE A  88
ILE A  71
 None
 1.24A 5hi2A-1yrwA:
undetectable		 5hi2A-1yrwA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yx2 AMINOMETHYLTRANSFERA
SE

(Bacillus
subtilis) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		5 ILE A 197
VAL A  57
ILE A 112
ILE A 134
ILE A 117
 None
 1.47A 5hi2A-1yx2A:
undetectable		 5hi2A-1yx2A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z26 ARGONAUTE

(Pyrococcus
furiosus) 		PF02171
(Piwi)
PF12212
(PAZ_siRNAbind) 		5 VAL A 661
VAL A  92
ILE A 101
ILE A  16
ILE A 312
 None
 1.30A 5hi2A-1z26A:
undetectable		 5hi2A-1z26A:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z68 FIBROBLAST
ACTIVATION PROTEIN,
ALPHA SUBUNIT

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		5 ILE A 339
ILE A 390
ILE A 429
ILE A 377
PHE A 368
 None
 1.48A 5hi2A-1z68A:
undetectable		 5hi2A-1z68A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7e PROTEIN ARNA

(Escherichia
coli) 		PF00551
(Formyl_trans_N)
PF01370
(Epimerase)
PF02911
(Formyl_trans_C) 		5 ILE A 144
VAL A 145
VAL A   4
ILE A  88
ILE A  71
 None
 1.24A 5hi2A-1z7eA:
undetectable		 5hi2A-1z7eA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbh 3'-5' EXONUCLEASE
ERI1

(Homo sapiens) 		PF00929
(RNase_T)
PF02037
(SAP) 		5 ILE A 152
ILE A 132
ILE A 166
ILE A 302
ASP A 297
 None
 1.45A 5hi2A-1zbhA:
undetectable		 5hi2A-1zbhA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zdr DIHYDROFOLATE
REDUCTASE

(Geobacillus
stearothermophilus) 		PF00186
(DHFR_1) 		5 ILE A 137
VAL A 138
ILE A  95
ILE A  86
ASP A 110
 None
 1.23A 5hi2A-1zdrA:
undetectable		 5hi2A-1zdrA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zjy R-SPECIFIC ALCOHOL
DEHYDROGENASE

(Lactobacillus
brevis) 		PF13561
(adh_short_C2) 		5 VAL A  87
ILE A  35
ILE A  22
ILE A  56
PHE A  80
 None
 1.04A 5hi2A-1zjyA:
undetectable		 5hi2A-1zjyA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zrz PROTEIN KINASE C,
IOTA

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		5 ILE A 251
VAL A 259
VAL A 296
ILE A 365
ASP A 387
 BI1  A1000 (-3.9A)
BI1  A1000 (-4.2A)
None
None
BI1  A1000 (-4.5A)
 0.95A 5hi2A-1zrzA:
22.4		 5hi2A-1zrzA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b1p MITOGEN-ACTIVATED
PROTEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A  70
VAL A  78
ILE A 123
ILE A 185
ILE A 205
 AIZ  A 501 ( 4.5A)
AIZ  A 501 ( 4.7A)
None
None
None
 1.08A 5hi2A-2b1pA:
19.1		 5hi2A-2b1pA:
26.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btw ALR0975 PROTEIN

(Nostoc sp. PCC
7120) 		PF05023
(Phytochelatin) 		5 ILE A 149
VAL A 139
ILE A 168
ILE A 132
ILE A 184
 None
 1.17A 5hi2A-2btwA:
undetectable		 5hi2A-2btwA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1h DELTA-AMINOLEVULINIC
ACID DEHYDRATASE

(Prosthecochloris
vibrioformis) 		PF00490
(ALAD) 		5 ILE A  81
VAL A  37
VAL A 271
ILE A 243
ILE A 194
 None
 1.16A 5hi2A-2c1hA:
undetectable		 5hi2A-2c1hA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2czd OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Pyrococcus
horikoshii) 		PF00215
(OMPdecase) 		5 ILE A  25
VAL A   3
ILE A  70
ILE A  35
ASP A  57
 None
None
None
None
DTT  A 501 ( 4.4A)
 1.50A 5hi2A-2czdA:
undetectable		 5hi2A-2czdA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2de0 ALPHA-(1,6)-FUCOSYLT
RANSFERASE

(Homo sapiens) 		PF14604
(SH3_9) 		5 VAL X 359
VAL X 474
ILE X 451
ASP X 453
PHE X 456
 None
 1.39A 5hi2A-2de0X:
undetectable		 5hi2A-2de0X:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7y TRNASE Z

(Thermotoga
maritima) 		PF12706
(Lactamase_B_2) 		5 VAL A  86
VAL A 127
ILE A 187
ILE A 145
ILE A  15
 None
 1.18A 5hi2A-2e7yA:
undetectable		 5hi2A-2e7yA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE

(Methanocaldococcus
jannaschii) 		PF01368
(DHH)
PF02833
(DHHA2) 		5 ILE A  63
VAL A   4
VAL A  42
ILE A 183
ILE A 144
 None
 1.39A 5hi2A-2eb0A:
undetectable		 5hi2A-2eb0A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f4z TGTWINSCAN_2721 - E2
DOMAIN

(Toxoplasma
gondii) 		PF00179
(UQ_con) 		5 ILE A  69
VAL A  70
ILE A 151
ILE A 117
ILE A  81
 None
 1.33A 5hi2A-2f4zA:
undetectable		 5hi2A-2f4zA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f4z TGTWINSCAN_2721 - E2
DOMAIN

(Toxoplasma
gondii) 		PF00179
(UQ_con) 		5 ILE A  69
VAL A  70
ILE A 151
ILE A 122
ILE A  81
 None
 1.40A 5hi2A-2f4zA:
undetectable		 5hi2A-2f4zA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g1s RENIN

(Homo sapiens) 		PF00026
(Asp) 		5 ILE A 329
ILE A 138
ILE A  19
ILE A 142
PHE A 153
 None
 1.38A 5hi2A-2g1sA:
undetectable		 5hi2A-2g1sA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g1s RENIN

(Homo sapiens) 		PF00026
(Asp) 		5 ILE A 329
VAL A  30
ILE A 138
ILE A  19
PHE A 153
 None
 1.20A 5hi2A-2g1sA:
undetectable		 5hi2A-2g1sA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gdz NAD+-DEPENDENT
15-HYDROXYPROSTAGLAN
DIN DEHYDROGENASE

(Homo sapiens) 		PF00106
(adh_short) 		5 VAL A  78
VAL A   3
ILE A 132
ILE A 230
ILE A 134
 None
 1.25A 5hi2A-2gdzA:
undetectable		 5hi2A-2gdzA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ge3 PROBABLE
ACETYLTRANSFERASE

(Agrobacterium
tumefaciens) 		PF00583
(Acetyltransf_1) 		5 ILE A  54
VAL A  50
VAL A  28
ILE A  93
ILE A  70
 None
None
None
ACO  A1301 (-4.0A)
None
 1.49A 5hi2A-2ge3A:
undetectable		 5hi2A-2ge3A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gfq UPF0204 PROTEIN
PH0006

(Pyrococcus
horikoshii) 		PF04414
(tRNA_deacylase) 		5 ILE A 113
VAL A 226
ILE A 195
ILE A 245
PHE A 238
 None
 1.32A 5hi2A-2gfqA:
undetectable		 5hi2A-2gfqA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gup ROK FAMILY PROTEIN

(Streptococcus
pneumoniae) 		PF00480
(ROK) 		5 ILE A 177
VAL A 176
VAL A 244
ILE A 123
ILE A 127
 None
 1.39A 5hi2A-2gupA:
undetectable		 5hi2A-2gupA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwg 4-OXALOMESACONATE
HYDRATASE

(Rhodopseudomonas
palustris) 		PF04909
(Amidohydro_2) 		5 VAL A  67
ILE A 255
ILE A 274
ILE A 221
ASP A 258
 None
 1.21A 5hi2A-2gwgA:
undetectable		 5hi2A-2gwgA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwn DIHYDROOROTASE

(Porphyromonas
gingivalis) 		PF01979
(Amidohydro_1) 		5 ILE A  31
VAL A  21
VAL A  85
ILE A  60
ASP A 384
 None
 1.08A 5hi2A-2gwnA:
undetectable		 5hi2A-2gwnA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h0r NICOTINAMIDASE

(Saccharomyces
cerevisiae) 		PF00857
(Isochorismatase) 		5 ILE A  89
VAL A 160
ILE A  32
ILE A  14
ASP A   8
 None
 1.05A 5hi2A-2h0rA:
undetectable		 5hi2A-2h0rA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hae MALATE
OXIDOREDUCTASE

(Thermotoga
maritima) 		PF00390
(malic)
PF03949
(Malic_M) 		5 VAL A 204
VAL A 312
ILE A 355
ILE A 300
PHE A 254
 None
 1.32A 5hi2A-2haeA:
undetectable		 5hi2A-2haeA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hdi COLICIN I RECEPTOR

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 VAL A 114
VAL A 153
ILE A 133
ILE A 125
PHE A 120
 None
 1.08A 5hi2A-2hdiA:
undetectable		 5hi2A-2hdiA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hj0 PUTATIVE CITRATE
LYASE, ALFA SUBUNIT

(Streptococcus
mutans) 		PF04223
(CitF) 		5 ILE A 432
VAL A 383
VAL A 263
ILE A 369
ASP A 439
 None
 1.47A 5hi2A-2hj0A:
undetectable		 5hi2A-2hj0A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hw6 MAP
KINASE-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  63
ILE A 107
ILE A 166
ILE A 189
ASP A 191
 None
 1.24A 5hi2A-2hw6A:
22.2		 5hi2A-2hw6A:
27.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i5b PHOSPHOMETHYLPYRIMID
INE KINASE

(Bacillus
subtilis) 		PF08543
(Phos_pyr_kin) 		5 ILE A  88
VAL A 222
ILE A 236
ILE A 138
ASP A 107
 None
 1.45A 5hi2A-2i5bA:
undetectable		 5hi2A-2i5bA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ich PUTATIVE ATTH

(Nitrosomonas
europaea) 		PF07143
(CrtC)
PF17186
(Lipocalin_9) 		5 ILE A 102
ILE A  68
ILE A 147
ASP A 108
PHE A 152
 None
 1.25A 5hi2A-2ichA:
undetectable		 5hi2A-2ichA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j4l URIDYLATE KINASE

(Sulfolobus
solfataricus) 		PF00696
(AA_kinase) 		5 ILE A 189
VAL A 192
VAL A  37
ILE A  27
ILE A   7
 None
 1.39A 5hi2A-2j4lA:
undetectable		 5hi2A-2j4lA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jc6 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1D

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  37
ILE A  81
ILE A 140
ILE A 163
 QPP  A1314 ( 4.6A)
None
None
None
 0.61A 5hi2A-2jc6A:
22.9		 5hi2A-2jc6A:
27.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jda YECBM32

(Yersinia
enterocolitica) 		PF00754
(F5_F8_type_C) 		5 VAL A  13
ILE A 113
ILE A  10
ILE A  59
PHE A  73
 GOL  A1147 ( 4.8A)
None
None
None
None
 1.41A 5hi2A-2jdaA:
undetectable		 5hi2A-2jdaA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jeo URIDINE-CYTIDINE
KINASE 1

(Homo sapiens) 		PF00485
(PRK) 		5 ILE A 209
VAL A 135
ILE A 104
ILE A 148
PHE A 143
 None
 1.40A 5hi2A-2jeoA:
undetectable		 5hi2A-2jeoA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kbs HARMONIN

(Homo sapiens) 		PF00595
(PDZ) 		5 ILE A  32
VAL A  62
ILE A  27
ILE A  87
ILE A  39
 None
 1.50A 5hi2A-2kbsA:
undetectable		 5hi2A-2kbsA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ke7 ANKYRIN REPEAT AND
STERILE ALPHA MOTIF
DOMAIN-CONTAINING
PROTEIN 1B

(Homo sapiens) 		PF00536
(SAM_1) 		5 VAL A 847
ILE A 856
ILE A 871
ILE A 858
ASP A 850
 None
 1.50A 5hi2A-2ke7A:
undetectable		 5hi2A-2ke7A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mh8 GA-79-MBP, MALTOSE
BINDING PROTEIN

(Streptococcus
dysgalactiae) 		PF17573
(GA-like) 		5 VAL A  42
ILE A  49
ILE A  33
ILE A  25
ASP A  19
 None
 1.18A 5hi2A-2mh8A:
undetectable		 5hi2A-2mh8A:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nly DIVERGENT
POLYSACCHARIDE
DEACETYLASE
HYPOTHETICAL PROTEIN

(Bacillus
halodurans) 		PF04748
(Polysacc_deac_2) 		5 VAL A 221
ILE A 232
ILE A  38
ILE A  56
ASP A  50
 None
 1.46A 5hi2A-2nlyA:
undetectable		 5hi2A-2nlyA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzu CATABOLITE CONTROL
PROTEIN

(Bacillus
megaterium) 		PF13377
(Peripla_BP_3) 		5 ILE G 272
VAL G 290
ILE G 148
ILE G 318
ASP G 160
 None
None
None
None
SO4  G 945 ( 4.2A)
 1.42A 5hi2A-2nzuG:
undetectable		 5hi2A-2nzuG:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3j UDP-GLUCOSE
6-DEHYDROGENASE

(Caenorhabditis
elegans) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		5 ILE A 458
VAL A 373
ILE A 338
ILE A 361
ILE A 325
 None
 1.27A 5hi2A-2o3jA:
undetectable		 5hi2A-2o3jA:
21.38