SIMILAR PATTERNS OF AMINO ACIDS FOR 5HHJ_B_GLYB404

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1adv ADENOVIRUS
SINGLE-STRANDED
DNA-BINDING PROTEIN

(Human
mastadenovirus
C) 		PF02236
(Viral_DNA_bi)
PF03728
(Viral_DNA_Zn_bi) 		4 GLN A 253
ALA A 250
GLN A 249
THR A 266
 None
 1.31A 5hhjB-1advA:
0.2		 5hhjB-1advA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h9r MOLYBDENUM TRANSPORT
PROTEIN MODE

(Escherichia
coli) 		PF03459
(TOBE) 		4 GLN A 197
ALA A 196
GLN A 202
THR A 248
 None
 1.09A 5hhjB-1h9rA:
0.0		 5hhjB-1h9rA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1io1 PHASE 1 FLAGELLIN

(Salmonella
enterica) 		PF00669
(Flagellin_N)
PF00700
(Flagellin_C)
PF08884
(Flagellin_D3) 		4 GLN A 429
ALA A  74
GLN A  75
THR A  77
 None
 1.30A 5hhjB-1io1A:
0.0		 5hhjB-1io1A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k25 LOW-AFFINITY
PENICILLIN-BINDING
PROTEIN 2X

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF03793
(PASTA) 		4 GLN A 452
ALA A 551
GLN A 552
THR A 550
 None
 1.46A 5hhjB-1k25A:
0.0		 5hhjB-1k25A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nqz COA PYROPHOSPHATASE
(MUTT/NUDIX FAMILY
PROTEIN)

(Deinococcus
radiodurans) 		PF00293
(NUDIX) 		4 GLN A  12
ALA A  67
GLN A  65
THR A  53
 None
 1.16A 5hhjB-1nqzA:
undetectable		 5hhjB-1nqzA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odo PUTATIVE CYTOCHROME
P450 154A1

(Streptomyces
coelicolor) 		PF00067
(p450) 		4 GLN A 181
ALA A 184
GLN A 185
THR A 188
 None
 1.10A 5hhjB-1odoA:
undetectable		 5hhjB-1odoA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j1n OUTER MEMBRANE
PROTEIN C

(Escherichia
coli) 		PF00267
(Porin_1) 		4 GLN A 175
ALA A 205
GLN A 206
THR A 208
 None
 1.15A 5hhjB-2j1nA:
0.0		 5hhjB-2j1nA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wed PENICILLOPEPSIN

(Penicillium
janthinellum) 		PF00026
(Asp) 		4 GLN A 232
ALA A 200
GLN A 203
THR A 199
 None
 1.11A 5hhjB-2wedA:
0.0		 5hhjB-2wedA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5x FLAGELLIN

(Salmonella
enterica) 		PF00669
(Flagellin_N)
PF00700
(Flagellin_C)
PF08884
(Flagellin_D3) 		4 GLN A 429
ALA A  74
GLN A  75
THR A  77
 None
 1.35A 5hhjB-3a5xA:
0.0		 5hhjB-3a5xA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e6e ALANINE RACEMASE

(Enterococcus
faecalis) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 GLN A 109
ALA A 151
GLN A 150
THR A 148
 None
 1.47A 5hhjB-3e6eA:
undetectable		 5hhjB-3e6eA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdu PUTATIVE ENOYL-COA
HYDRATASE/ISOMERASE

(Acinetobacter
baumannii) 		PF00378
(ECH_1) 		4 GLN A 199
ALA A 202
GLN A 203
THR A 206
 None
 0.66A 5hhjB-3fduA:
undetectable		 5hhjB-3fduA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l9x GLUTATHIONE-REGULATE
D POTASSIUM-EFFLUX
SYSTEM PROTEIN KEFC,
LINKER, ANCILLARY
PROTEIN KEFF

(Escherichia
coli) 		PF02254
(TrkA_N)
PF02525
(Flavodoxin_2) 		4 GLN A1126
ALA A1130
GLN A1129
THR A1131
 None
 1.49A 5hhjB-3l9xA:
undetectable		 5hhjB-3l9xA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3up1 INTERLEUKIN-7
RECEPTOR SUBUNIT
ALPHA

(Homo sapiens) 		PF00041
(fn3) 		4 GLN A 151
ALA A 179
GLN A 176
THR A 208
 None
 1.44A 5hhjB-3up1A:
undetectable		 5hhjB-3up1A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f5x RNA-DIRECTED RNA
POLYMERASE

(Rotavirus A) 		PF02123
(RdRP_4)
PF12289
(Rotavirus_VP1) 		4 GLN W 346
ALA W 588
GLN W 528
THR W 531
 None
 1.32A 5hhjB-4f5xW:
10.1		 5hhjB-4f5xW:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p94 CONSERVED FLAGELLAR
PROTEIN F

(Sulfolobus
acidocaldarius) 		no annotation 4 GLN A  88
ALA A 146
GLN A 145
THR A 144
 None
 1.31A 5hhjB-4p94A:
undetectable		 5hhjB-4p94A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6r SPHINGOSINE-1-PHOSPH
ATE LYASE 1

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		4 GLN A 478
ALA A 529
GLN A 530
THR A 532
 None
 1.21A 5hhjB-4q6rA:
undetectable		 5hhjB-4q6rA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dh2 SIDEROPHORE
PERIPLASMIC BINDING
PROTEIN

(Thermobifida
fusca) 		PF01497
(Peripla_BP_2) 		4 GLN A 274
ALA A 241
GLN A 270
THR A 239
 None
 1.36A 5hhjB-5dh2A:
undetectable		 5hhjB-5dh2A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
5

(Homo sapiens) 		PF00005
(ABC_tran)
PF01061
(ABC2_membrane) 		4 GLN A 206
ALA A 205
GLN A 209
THR A 151
 None
 1.33A 5hhjB-5do7A:
undetectable		 5hhjB-5do7A:
18.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hhl RETRON-TYPE REVERSE
TRANSCRIPTASE

([Eubacterium]
rectale) 		PF00078
(RVT_1) 		4 GLN A  92
ALA A  95
GLN A  96
THR A  99
 None
 0.17A 5hhjB-5hhlA:
45.7		 5hhjB-5hhlA:
94.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2

(Synechocystis
sp. PCC 6803) 		no annotation 4 GLN b  10
ALA b  13
GLN b  14
THR b   3
 None
 1.25A 5hhjB-5oy0b:
undetectable		 5hhjB-5oy0b:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c4m YERSINOPINE
DEHYDROGENASE

(Yersinia pestis) 		no annotation 4 GLN C 260
ALA C 254
GLN C 253
THR C 251
 None
 1.36A 5hhjB-6c4mC:
undetectable		 5hhjB-6c4mC:
undetectable