SIMILAR PATTERNS OF AMINO ACIDS FOR 5HHJ_A_GLYA404_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m56 CAMPHOR
5-MONOOXYGENASE

(Pseudomonas
putida) 		PF00067
(p450) 		4 TYR A  29
ASN A  59
ILE A  88
GLN A 317
 None
 1.43A 5hhjA-2m56A:
0.0		 5hhjA-2m56A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wdw PUTATIVE HEXOSE
OXIDASE

(Nonomuraea
gerenzanensis) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 TYR A 473
ASN A 427
ILE A 401
GLN A 294
 FAD  A 601 ( 4.9A)
None
None
None
 1.19A 5hhjA-2wdwA:
0.7		 5hhjA-2wdwA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzy FLAGELLAR ASSOCIATED
PROTEIN

(Chlamydomonas
reinhardtii) 		PF12895
(ANAPC3)
PF13174
(TPR_6) 		4 TYR A 425
ASN A 433
ILE A 437
GLN A 440
 None
MLI  A1648 (-4.6A)
None
None
 1.20A 5hhjA-4uzyA:
0.0		 5hhjA-4uzyA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yg8 CHITIN BIOSYNTHESIS
PROTEIN CHS6

(Saccharomyces
cerevisiae) 		PF09295
(ChAPs) 		4 TYR B 689
ASN B 465
ILE B 464
GLN B 456
 None
 1.26A 5hhjA-4yg8B:
0.0		 5hhjA-4yg8B:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5doi TELOMERASE-ASSOCIATE
D PROTEIN 19

(Tetrahymena
thermophila) 		no annotation 4 TYR A  94
ASN A 107
ILE A 138
GLN A  31
 None
 1.12A 5hhjA-5doiA:
0.0		 5hhjA-5doiA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kws GALACTOSE-BINDING
PROTEIN

(Yersinia pestis) 		PF13407
(Peripla_BP_4) 		4 TYR A  90
ASN A  66
ILE A  65
GLN A  48
 None
 1.41A 5hhjA-5kwsA:
0.0		 5hhjA-5kwsA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ekt P-47 PROTEIN

(Clostridium
botulinum) 		no annotation 4 TYR A  45
ASN A  49
ILE A  51
GLN A 172
 None
 1.28A 5hhjA-6ektA:
0.0		 5hhjA-6ektA:
22.29