SIMILAR PATTERNS OF AMINO ACIDS FOR 5HGC_A_HCYA501
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e4e | VANCOMYCIN/TEICOPLANIN A-TYPE RESISTANCEPROTEIN VANA (Enterococcusfaecium) |
PF01820(Dala_Dala_lig_N)PF07478(Dala_Dala_lig_C) | 5 | VAL B 260PRO B 261ALA B 262ILE B 272GLN B 273 | None | 1.00A | 5hgcA-1e4eB:0.0 | 5hgcA-1e4eB:21.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g6o | CAG-ALPHA (Helicobacterpylori) |
PF00437(T2SSE) | 5 | VAL A 58THR A 32PHE A 84ILE A 130PHE A 36 | None | 1.09A | 5hgcA-1g6oA:0.6 | 5hgcA-1g6oA:22.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gpe | PROTEIN (GLUCOSEOXIDASE) (Penicilliumamagasakiense) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 5 | PRO A 118THR A 361PHE A 414ILE A 433GLN A 559 | None | 1.39A | 5hgcA-1gpeA:0.0 | 5hgcA-1gpeA:21.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gtk | PORPHOBILINOGENDEAMINASE (Escherichiacoli) |
PF01379(Porphobil_deam)PF03900(Porphobil_deamC) | 5 | VAL A 39PRO A 40ALA A 9ARG A 211ILE A 77 | None | 1.27A | 5hgcA-1gtkA:undetectable | 5hgcA-1gtkA:19.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1iub | FUCOSE-SPECIFICLECTIN (Aleuriaaurantia) |
PF07938(Fungal_lectin) | 5 | ALA A 12THR A 306PHE A 4ILE A 10SER A 8 | None | 1.43A | 5hgcA-1iubA:undetectable | 5hgcA-1iubA:20.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j71 | ASPARTIC PROTEINASE (Candidatropicalis) |
PF00026(Asp) | 5 | VAL A 310ALA A 155THR A 5LYS A 153ILE A 151 | EOH A 573 (-4.6A)NoneNoneNoneNone | 1.39A | 5hgcA-1j71A:0.0 | 5hgcA-1j71A:21.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kuu | CONSERVED PROTEIN (Methanothermobacter) |
PF07826(IMP_cyclohyd) | 5 | ALA A 187THR A 156PHE A 176ILE A 170PHE A 158 | None | 1.34A | 5hgcA-1kuuA:0.7 | 5hgcA-1kuuA:19.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lsh | LIPOVITELLIN (LV-1N,LV-1C) (Ichthyomyzonunicuspis) |
PF01347(Vitellogenin_N)PF09172(DUF1943) | 5 | PRO A 653THR A 508ILE A 647GLN A 578SER A 544 | UPL A2032 ( 4.6A)NoneNoneNoneNone | 1.26A | 5hgcA-1lshA:0.0 | 5hgcA-1lshA:17.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1n47 | ISOLECTIN B4 (Vicia villosa) |
PF00139(Lectin_legB) | 5 | VAL A 189ALA A 176PHE A 73ILE A 163PHE A 124 | None | 1.37A | 5hgcA-1n47A:0.0 | 5hgcA-1n47A:18.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o99 | 2,3-BISPHOSPHOGLYCERATE-INDEPENDENTPHOSPHOGLYCERATEMUTASE (Geobacillusstearothermophilus) |
PF01676(Metalloenzyme)PF06415(iPGM_N) | 5 | ALA A 201PHE A 257ILE A 268GLN A 267PHE A 149 | None | 1.03A | 5hgcA-1o99A:undetectable | 5hgcA-1o99A:21.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1obf | GLYCERALDEHYDE3-PHOSPHATEDEHYDROGENASE (Achromobacterxylosoxidans) |
PF00044(Gp_dh_N)PF02800(Gp_dh_C) | 5 | PRO O 86THR O 99PHE O 102GLN O 84ASN O 35 | None | 1.38A | 5hgcA-1obfO:undetectable | 5hgcA-1obfO:20.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q8f | PYRIMIDINENUCLEOSIDE HYDROLASE (Escherichiacoli) |
PF01156(IU_nuc_hydro) | 5 | THR A 160PHE A 168ILE A 76GLN A 74PHE A 159 | NoneNoneNoneGOL A3009 ( 3.5A)GOL A3005 (-4.9A) | 1.25A | 5hgcA-1q8fA:undetectable | 5hgcA-1q8fA:21.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qrh | ECO RI ENDONCULEASE (Escherichiacoli) |
PF02963(EcoRI) | 5 | ALA A 139THR A 239ILE A 143PHE A 174ASN A 199 | None | 1.12A | 5hgcA-1qrhA:undetectable | 5hgcA-1qrhA:21.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1r30 | BIOTIN SYNTHASE (Escherichiacoli) |
PF04055(Radical_SAM)PF06968(BATS) | 5 | VAL A 259PHE A 305ILE A 284PHE A 277ASN A 282 | None | 1.37A | 5hgcA-1r30A:undetectable | 5hgcA-1r30A:20.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sqj | OLIGOXYLOGLUCANREDUCING-END-SPECIFIC CELLOBIOHYDROLASE (Geotrichum sp.M128) |
PF15899(BNR_6) | 5 | PRO A 368ILE A 466SER A 467PHE A 372ASN A 373 | None | 1.30A | 5hgcA-1sqjA:undetectable | 5hgcA-1sqjA:17.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t90 | PROBABLEMETHYLMALONATE-SEMIALDEHYDEDEHYDROGENASE (Bacillussubtilis) |
PF00171(Aldedh) | 5 | VAL A 326PRO A 325ALA A 280PHE A 384ASN A 331 | NoneNoneNoneNAD A1490 (-3.7A)None | 1.20A | 5hgcA-1t90A:undetectable | 5hgcA-1t90A:21.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1typ | TRYPANOTHIONEREDUCTASE (Crithidiafasciculata) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | PRO A 336THR A 348ILE A 325SER A 315ASN A 340 | FAD A 493 (-4.4A)NoneNoneNoneNone | 1.33A | 5hgcA-1typA:undetectable | 5hgcA-1typA:23.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vmi | PUTATIVE PHOSPHATEACETYLTRANSFERASE (Escherichiacoli) |
PF01515(PTA_PTB) | 5 | VAL A 318ALA A 316ILE A 312GLN A 310SER A 308 | None | 1.11A | 5hgcA-1vmiA:undetectable | 5hgcA-1vmiA:19.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2aw5 | NADP-DEPENDENT MALICENZYME (Homo sapiens) |
PF00390(malic)PF03949(Malic_M) | 5 | VAL A 276ALA A 274ARG A 155ILE A 270ASN A 454 | None | 1.44A | 5hgcA-2aw5A:undetectable | 5hgcA-2aw5A:20.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2azp | HYPOTHETICAL PROTEINPA1268 (Pseudomonasaeruginosa) |
PF05544(Pro_racemase) | 5 | VAL A 119ALA A 121PHE A 269ILE A 93ASN A 133 | None | 1.03A | 5hgcA-2azpA:undetectable | 5hgcA-2azpA:20.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2azp | HYPOTHETICAL PROTEINPA1268 (Pseudomonasaeruginosa) |
PF05544(Pro_racemase) | 5 | VAL A 119ALA A 121THR A 240ILE A 93ASN A 133 | None | 1.41A | 5hgcA-2azpA:undetectable | 5hgcA-2azpA:20.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dpm | PROTEIN(ADENINE-SPECIFICMETHYLTRANSFERASEDPNII 1) (Streptococcuspneumoniae) |
PF02086(MethyltransfD12) | 5 | VAL A 115ALA A 118ILE A 74SER A 163ASN A 77 | None | 1.30A | 5hgcA-2dpmA:undetectable | 5hgcA-2dpmA:20.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ep7 | GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE (Aquifexaeolicus) |
PF00044(Gp_dh_N)PF02800(Gp_dh_C) | 5 | PRO A 84THR A 97PHE A 100GLN A 82ASN A 33 | NoneNAD A 401 (-4.0A)NAD A 401 (-4.7A)NoneNAD A 401 (-4.2A) | 1.33A | 5hgcA-2ep7A:undetectable | 5hgcA-2ep7A:22.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f6a | COLLAGEN ADHESIN (Staphylococcusaureus) |
PF05737(Collagen_bind) | 5 | PRO A 93ALA A 104THR A 55ILE A 106ASN A 322 | None | 1.21A | 5hgcA-2f6aA:undetectable | 5hgcA-2f6aA:20.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f6a | COLLAGEN ADHESIN (Staphylococcusaureus) |
PF05737(Collagen_bind) | 5 | PRO A 93ALA A 104THR A 55ILE A 106PHE A 131 | None | 1.34A | 5hgcA-2f6aA:undetectable | 5hgcA-2f6aA:20.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2np0 | BOTULINUM NEUROTOXINTYPE B (Clostridiumbotulinum) |
PF01742(Peptidase_M27)PF07951(Toxin_R_bind_C)PF07952(Toxin_trans)PF07953(Toxin_R_bind_N) | 5 | VAL A 249PRO A 250ALA A 457THR A 283ILE A 278 | None | 1.25A | 5hgcA-2np0A:undetectable | 5hgcA-2np0A:14.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o0y | TRANSCRIPTIONALREGULATOR (Rhodococcus sp.) |
PF01614(IclR)PF09339(HTH_IclR) | 5 | VAL A 126ALA A 128THR A 244SER A 107ASN A 115 | None | 1.29A | 5hgcA-2o0yA:undetectable | 5hgcA-2o0yA:21.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o2c | GLUCOSE-6-PHOSPHATEISOMERASE,GLYCOSOMAL (Trypanosomabrucei) |
PF00342(PGI) | 5 | VAL A 378ALA A 374ARG A 419LYS A 549SER A 561 | None | 1.32A | 5hgcA-2o2cA:undetectable | 5hgcA-2o2cA:22.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2psb | YERB PROTEIN (Bacillussubtilis) |
PF11258(DUF3048)PF17479(DUF3048_C) | 5 | VAL A 278PRO A 279THR A 165ILE A 54PHE A 96 | None | 1.41A | 5hgcA-2psbA:undetectable | 5hgcA-2psbA:22.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qvx | 4-CHLOROBENZOATE COALIGASE (Alcaligenes sp.AL3007) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 5 | VAL X 432ALA X 446THR X 423PHE X 464SER X 468 | None | 1.28A | 5hgcA-2qvxX:undetectable | 5hgcA-2qvxX:20.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rc5 | FERREDOXIN-NADPREDUCTASE (Leptospirainterrogans) |
PF00175(NAD_binding_1) | 5 | VAL A 26ALA A 24ILE A 112SER A 100PHE A 114 | None | 1.24A | 5hgcA-2rc5A:undetectable | 5hgcA-2rc5A:20.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rdy | BH0842 PROTEIN (Bacillushalodurans) |
PF14498(Glyco_hyd_65N_2) | 5 | VAL A 433PRO A 87ALA A 431PHE A 397ASN A 423 | None | 1.45A | 5hgcA-2rdyA:undetectable | 5hgcA-2rdyA:19.95 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2v95 | CORTICOSTEROID-BINDING GLOBULIN (Rattusnorvegicus) |
PF00079(Serpin) | 5 | PRO A 14THR A 232PHE A 234ILE A 255PHE A 357 | HCY A1375 (-3.4A)HCY A1375 ( 4.2A)HCY A1375 (-4.8A)NoneHCY A1375 ( 4.1A) | 0.54A | 5hgcA-2v95A:22.9 | 5hgcA-2v95A:39.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vpw | HYPOTHETICALMEMBRANE SPANNINGPROTEINNRFC PROTEIN (Thermusthermophilus) |
PF13247(Fer4_11)PF14589(NrfD_2) | 5 | VAL B 85PRO B 87ALA B 74ILE B 91SER C 68 | SF4 B1197 ( 4.8A)NoneSF4 B1197 ( 4.0A)SF4 B1197 ( 4.3A)MQ7 C1252 ( 4.9A) | 1.24A | 5hgcA-2vpwB:undetectable | 5hgcA-2vpwB:19.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x50 | TRYPANOTHIONEREDUCTASE (Leishmaniainfantum) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | PRO A 336THR A 348ILE A 325SER A 315ASN A 340 | FAD A1487 (-4.4A)NoneNoneNoneNone | 1.40A | 5hgcA-2x50A:undetectable | 5hgcA-2x50A:20.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xsg | CCMAN5 (Cellulosimicrobiumcellulans) |
PF07971(Glyco_hydro_92) | 5 | ALA A 98THR A 63LYS A 58ILE A 59GLN A 56 | None | 0.98A | 5hgcA-2xsgA:undetectable | 5hgcA-2xsgA:18.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ygl | BLOOD GROUP A-ANDB-CLEAVINGENDO-BETA-GALACTOSIDASE (Streptococcuspneumoniae) |
PF08305(NPCBM) | 5 | ALA A 124THR A 189PHE A 185ILE A 165SER A 177 | None | 1.42A | 5hgcA-2yglA:undetectable | 5hgcA-2yglA:21.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yys | PROLINEIMINOPEPTIDASE-RELATED PROTEIN (Thermusthermophilus) |
PF12697(Abhydrolase_6) | 5 | VAL A 277PRO A 278ALA A 275PHE A 269ILE A 123 | None | 1.44A | 5hgcA-2yysA:undetectable | 5hgcA-2yysA:21.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2znm | THIOL:DISULFIDEINTERCHANGE PROTEINDSBA (Neisseriameningitidis) |
PF13462(Thioredoxin_4) | 5 | ARG A 161THR A 153ILE A 16GLN A 145PHE A 29 | None | 1.32A | 5hgcA-2znmA:undetectable | 5hgcA-2znmA:19.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cdi | POLYNUCLEOTIDEPHOSPHORYLASE (Escherichiacoli) |
PF01138(RNase_PH)PF03725(RNase_PH_C)PF03726(PNPase) | 5 | PRO A 171PHE A 130ILE A 166PHE A 126ASN A 169 | None | 1.36A | 5hgcA-3cdiA:undetectable | 5hgcA-3cdiA:19.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dp7 | SAM-DEPENDENTMETHYLTRANSFERASE (Bacteroidesvulgatus) |
PF00891(Methyltransf_2) | 5 | VAL A 69ALA A 67THR A 79PHE A 41ILE A 40 | None | 1.44A | 5hgcA-3dp7A:undetectable | 5hgcA-3dp7A:21.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eb7 | INSECTICIDALDELTA-ENDOTOXINCRY8EA1 (Bacillusthuringiensis) |
PF00555(Endotoxin_M)PF03944(Endotoxin_C)PF03945(Endotoxin_N) | 5 | ALA A 519ARG A 478THR A 496PHE A 342ILE A 374 | None | 1.30A | 5hgcA-3eb7A:undetectable | 5hgcA-3eb7A:22.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h5j | 3-ISOPROPYLMALATEDEHYDRATASE SMALLSUBUNIT (Mycobacteriumtuberculosis) |
PF00694(Aconitase_C) | 5 | VAL A 149ALA A 146ARG A 15ILE A 127GLN A 129 | None | 1.21A | 5hgcA-3h5jA:undetectable | 5hgcA-3h5jA:18.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i6y | ESTERASE APC40077 (Oleispiraantarctica) |
PF00756(Esterase) | 5 | VAL A 46PRO A 47ALA A 78ILE A 132PHE A 136 | None | 1.37A | 5hgcA-3i6yA:undetectable | 5hgcA-3i6yA:20.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jac | PIEZO-TYPEMECHANOSENSITIVE IONCHANNEL COMPONENT 1 (Mus musculus) |
PF12166(Piezo_RRas_bdg) | 5 | THR A2336ILE A2448GLN A2222SER A2450PHE A2323 | None | 1.37A | 5hgcA-3jacA:undetectable | 5hgcA-3jacA:19.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l7n | PUTATIVEUNCHARACTERIZEDPROTEIN (Streptococcusmutans) |
PF00117(GATase) | 5 | VAL A 90ALA A 175PHE A 133ILE A 166GLN A 165 | None | 1.30A | 5hgcA-3l7nA:undetectable | 5hgcA-3l7nA:20.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n0r | RESPONSE REGULATOR (Caulobactervibrioides) |
PF00072(Response_reg) | 5 | VAL A 151PRO A 150ALA A 153ILE A 219PHE A 242 | None | 1.17A | 5hgcA-3n0rA:undetectable | 5hgcA-3n0rA:22.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o65 | PUTATIVEATAXIN-3-LIKEPROTEIN (Homo sapiens) |
PF02099(Josephin) | 5 | PHE A 127LYS A 1ILE A 5PHE A 132ASN A 133 | None | 1.34A | 5hgcA-3o65A:undetectable | 5hgcA-3o65A:18.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oo9 | ABC TRANSPORTERBINDING PROTEIN ACBH (Actinoplanessp. SE50/110) |
PF01547(SBP_bac_1) | 6 | ALA A 258PHE A 270ILE A 342GLN A 343SER A 346PHE A 134 | SO4 A 409 ( 4.2A)NoneNoneNoneNoneNone | 1.49A | 5hgcA-3oo9A:undetectable | 5hgcA-3oo9A:23.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ot2 | UNCHARACTERIZEDPROTEIN (Trichormusvariabilis) |
PF05685(Uma2) | 5 | ARG A 69PHE A 14ILE A 31GLN A 33SER A 24 | BU1 A 189 ( 4.2A)BU1 A 189 (-4.0A)NoneNoneBU1 A 189 ( 4.2A) | 1.33A | 5hgcA-3ot2A:undetectable | 5hgcA-3ot2A:20.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qjp | PUTATIVEUNCHARACTERIZEDPROTEIN PH0350 (Pyrococcushorikoshii) |
PF01881(Cas_Cas6) | 5 | VAL A 109PRO A 98PHE A 52ILE A 28GLN A 27 | None | 1.36A | 5hgcA-3qjpA:undetectable | 5hgcA-3qjpA:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t57 | UDP-N-ACETYLGLUCOSAMINEO-ACYLTRANSFERASEDOMAIN-CONTAININGPROTEIN (Arabidopsisthaliana) |
PF00132(Hexapep)PF13720(Acetyltransf_11) | 5 | VAL A 236PRO A 237ALA A 224THR A 194PHE A 190 | None | 1.41A | 5hgcA-3t57A:undetectable | 5hgcA-3t57A:20.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ty6 | ATP-DEPENDENTPROTEASE SUBUNITHSLV (Bacillusanthracis) |
PF00227(Proteasome) | 5 | VAL A 177ALA A 19ILE A 156GLN A 155PHE A 10 | None | 1.33A | 5hgcA-3ty6A:undetectable | 5hgcA-3ty6A:19.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u1k | POLYRIBONUCLEOTIDENUCLEOTIDYLTRANSFERASE 1, MITOCHONDRIAL (Homo sapiens) |
PF00013(KH_1)PF01138(RNase_PH)PF03725(RNase_PH_C)PF03726(PNPase) | 5 | ARG A 617PHE A 647ILE A 639PHE A 620ASN A 627 | None | 1.25A | 5hgcA-3u1kA:undetectable | 5hgcA-3u1kA:21.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ucq | AMYLOSUCRASE (Deinococcusgeothermalis) |
PF00128(Alpha-amylase) | 5 | PRO A 227ILE A 221GLN A 440PHE A 248ASN A 249 | NoneTRS A 700 (-4.4A)GOL A 712 ( 3.6A)GOL A 720 (-4.2A)GOL A 711 (-3.6A) | 1.03A | 5hgcA-3ucqA:undetectable | 5hgcA-3ucqA:17.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ufc | PUTATIVEUNCHARACTERIZEDPROTEIN (Pyrococcusfuriosus) |
PF01881(Cas_Cas6) | 5 | VAL X 109PRO X 98PHE X 52ILE X 28GLN X 27 | None | 1.35A | 5hgcA-3ufcX:undetectable | 5hgcA-3ufcX:21.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zuq | BOTULINUM NEUROTOXINTYPE B (Clostridiumbotulinum) |
PF01742(Peptidase_M27)PF07952(Toxin_trans) | 5 | VAL A 250PRO A 251ALA A 493THR A 284ILE A 279 | None | 1.35A | 5hgcA-3zuqA:undetectable | 5hgcA-3zuqA:18.15 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4c41 | CORTICOSTEROID-BINDING GLOBULIN (Homo sapiens) |
PF00079(Serpin) | 5 | THR A 240PHE A 242ILE A 263SER A 267PHE A 366 | None | 0.80A | 5hgcA-4c41A:45.2 | 5hgcA-4c41A:41.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cfi | FLAGELLIN (Burkholderiapseudomallei) |
PF00669(Flagellin_N)PF12613(FliC_SP) | 5 | ALA A 259THR A 239PHE A 218ILE A 206PHE A 235 | None | 1.39A | 5hgcA-4cfiA:undetectable | 5hgcA-4cfiA:21.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e4t | PHOSPHORIBOSYLAMINOIMIDAZOLECARBOXYLASE, ATPASESUBUNIT (Burkholderiaambifaria) |
PF02222(ATP-grasp) | 5 | VAL A 232PRO A 233ALA A 234PHE A 266GLN A 246 | None | 1.06A | 5hgcA-4e4tA:undetectable | 5hgcA-4e4tA:20.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fdh | CYTOCHROME P45011B2, MITOCHONDRIAL (Homo sapiens) |
PF00067(p450) | 5 | PRO A 322THR A 475ILE A 481SER A 494PHE A 328 | None | 1.35A | 5hgcA-4fdhA:undetectable | 5hgcA-4fdhA:20.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fzd | SERINE/THREONINE-PROTEIN KINASE MST4 (Homo sapiens) |
PF00069(Pkinase) | 5 | PRO B 115PHE B 273ILE B 121GLN B 120PHE B 247 | None | 1.40A | 5hgcA-4fzdB:undetectable | 5hgcA-4fzdB:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fzd | SERINE/THREONINE-PROTEIN KINASE MST4 (Homo sapiens) |
PF00069(Pkinase) | 5 | THR B 244PHE B 273ILE B 121GLN B 120PHE B 247 | None | 1.36A | 5hgcA-4fzdB:undetectable | 5hgcA-4fzdB:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iox | TRIPARTITE TERMINASESUBUNIT UL15 (Humanalphaherpesvirus1) |
PF02499(DNA_pack_C) | 5 | VAL A 477PRO A 476PHE A 486LYS A 480PHE A 651 | None | 1.33A | 5hgcA-4ioxA:undetectable | 5hgcA-4ioxA:21.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4izo | PHOSPHORIBOSYLAMINOIMIDAZOLECARBOXYLASE, ATPASESUBUNIT (Burkholderiathailandensis) |
PF02222(ATP-grasp) | 5 | VAL A 232PRO A 233ALA A 234PHE A 266GLN A 246 | None | 0.99A | 5hgcA-4izoA:undetectable | 5hgcA-4izoA:21.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j9w | PROLINE RACEMASEFAMILY PROTEIN (Pseudomonasprotegens) |
PF05544(Pro_racemase) | 5 | VAL A 119ALA A 121PHE A 269ILE A 93ASN A 133 | NoneNoneGOL A 404 (-4.7A)NoneNone | 1.01A | 5hgcA-4j9wA:undetectable | 5hgcA-4j9wA:20.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4li3 | CYSTEINE SYNTHASE (Haemophilusinfluenzae) |
PF00291(PALP) | 5 | ALA X 76THR X 156ILE X 45SER X 181ASN X 36 | LLP X 42 ( 3.2A)NoneLLP X 42 ( 4.0A)LLP X 42 ( 2.4A)None | 1.33A | 5hgcA-4li3X:undetectable | 5hgcA-4li3X:22.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n40 | PROTEIN ECT2 (Homo sapiens) |
PF00533(BRCT)PF12738(PTCB-BRCT) | 5 | VAL A 123ALA A 68ILE A 66GLN A 62PHE A 76 | None | 1.07A | 5hgcA-4n40A:undetectable | 5hgcA-4n40A:20.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o9x | TCDB2, TCCC3 (Photorhabdusluminescens) |
PF03534(SpvB)PF12255(TcdB_toxin_midC)PF12256(TcdB_toxin_midN) | 5 | VAL A 433ALA A 699ILE A 710GLN A 695SER A 712 | None | 1.28A | 5hgcA-4o9xA:undetectable | 5hgcA-4o9xA:10.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pj6 | LEUCYL-CYSTINYLAMINOPEPTIDASE (Homo sapiens) |
PF01433(Peptidase_M1)PF11838(ERAP1_C) | 5 | VAL A 194THR A 292LYS A 318ILE A 319SER A 329 | None | 1.28A | 5hgcA-4pj6A:undetectable | 5hgcA-4pj6A:18.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r84 | SIALYLTRANSFERASE0160 (Photobacteriumdamselae) |
PF11477(PM0188) | 5 | VAL A 178THR A 197ILE A 210GLN A 211PHE A 195 | None | 1.39A | 5hgcA-4r84A:undetectable | 5hgcA-4r84A:20.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r9v | SIALYLTRANSFERASE0160 (Photobacteriumdamselae) |
PF11477(PM0188) | 5 | VAL A 178THR A 197ILE A 210GLN A 211PHE A 195 | None | 1.32A | 5hgcA-4r9vA:undetectable | 5hgcA-4r9vA:21.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u1f | EUKARYOTICTRANSLATIONINITIATION FACTOR 3SUBUNIT B (Saccharomycescerevisiae) |
PF08662(eIF2A) | 5 | THR A 464PHE A 462ILE A 431PHE A 453ASN A 414 | None | 1.34A | 5hgcA-4u1fA:undetectable | 5hgcA-4u1fA:21.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uap | GLYCOSYL HYDROLASE,FAMILY31/FIBRONECTIN TYPEIII DOMAIN PROTEIN (Clostridiumperfringens) |
no annotation | 5 | VAL A 116PHE A 62ILE A 127PHE A 148ASN A 70 | None | 1.39A | 5hgcA-4uapA:undetectable | 5hgcA-4uapA:17.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uer | EIF3B (Lachanceakluyveri) |
PF00318(Ribosomal_S2) | 5 | THR b 530PHE b 528ILE b 497PHE b 519ASN b 480 | None | 1.35A | 5hgcA-4uerb:undetectable | 5hgcA-4uerb:19.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4v33 | POLYSACCHARIDEDEACETYLASE-LIKEPROTEIN (Bacillusanthracis) |
PF01522(Polysacc_deac_1) | 5 | ALA A 89PHE A 105ILE A 79GLN A 118PHE A 110 | None | 1.06A | 5hgcA-4v33A:undetectable | 5hgcA-4v33A:22.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4v33 | POLYSACCHARIDEDEACETYLASE-LIKEPROTEIN (Bacillusanthracis) |
PF01522(Polysacc_deac_1) | 5 | ALA A 89PHE A 105LYS A 78ILE A 79PHE A 110 | None | 1.09A | 5hgcA-4v33A:undetectable | 5hgcA-4v33A:22.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xb3 | GLUCAN1,6-ALPHA-GLUCOSIDASE (Streptococcusmutans) |
PF00128(Alpha-amylase)PF16657(Malt_amylase_C) | 5 | VAL A 475ALA A 477THR A 514PHE A 531ASN A 492 | None | 1.41A | 5hgcA-4xb3A:undetectable | 5hgcA-4xb3A:21.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5aa4 | MEMBRANE-BOUND LYTICMUREINTRANSGLYCOSYLASE F (Pseudomonasaeruginosa) |
PF00497(SBP_bac_3)PF01464(SLT) | 5 | LYS B 352ILE B 355GLN B 356SER B 359PHE B 295 | None | 1.28A | 5hgcA-5aa4B:undetectable | 5hgcA-5aa4B:20.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bwa | ORNITHINEDECARBOXYLASE (Homo sapiens) |
PF00278(Orn_DAP_Arg_deC)PF02784(Orn_Arg_deC_N) | 5 | VAL A 192THR A 63PHE A 65ILE A 109GLN A 129 | None | 1.29A | 5hgcA-5bwaA:undetectable | 5hgcA-5bwaA:23.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5d0f | UNCHARACTERIZEDPROTEIN ([Candida]glabrata) |
PF06202(GDE_C)PF14699(hGDE_N)PF14701(hDGE_amylase)PF14702(hGDE_central) | 5 | VAL A 18PRO A 17THR A1029ILE A 53SER A 57 | None | 1.22A | 5hgcA-5d0fA:undetectable | 5hgcA-5d0fA:13.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ew5 | COLICIN-E9 (Escherichiacoli) |
PF03515(Cloacin) | 5 | VAL A 230PRO A 229PHE A 275ILE A 273ASN A 232 | None | 1.39A | 5hgcA-5ew5A:undetectable | 5hgcA-5ew5A:19.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hqj | PERIPLASMIC BINDINGPROTEIN/LACITRANSCRIPTIONALREGULATOR (Paraburkholderiagraminis) |
PF13407(Peripla_BP_4) | 5 | VAL A 222PRO A 225ALA A 226THR A 189ILE A 216 | CL A 402 ( 4.4A) CL A 402 ( 4.9A)NoneNoneNone | 1.41A | 5hgcA-5hqjA:undetectable | 5hgcA-5hqjA:19.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i6c | URIC ACID-XANTHINEPERMEASE (Aspergillusnidulans) |
PF00860(Xan_ur_permease) | 5 | ALA A 89THR A 404SER A 127PHE A 406ASN A 409 | NoneXAN A1001 (-4.7A)NoneXAN A1001 (-3.5A)None | 1.44A | 5hgcA-5i6cA:undetectable | 5hgcA-5i6cA:20.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j90 | RAGB/SUSD DOMAINPROTEIN (Flavobacteriumjohnsoniae) |
PF12741(SusD-like) | 5 | VAL A 115ALA A 119THR A 205PHE A 202PHE A 51 | None | 1.35A | 5hgcA-5j90A:undetectable | 5hgcA-5j90A:20.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mal | LIPASE (Streptomycesrimosus) |
PF13472(Lipase_GDSL_2) | 5 | ARG A 104THR A 89ILE A 112PHE A 86ASN A 82 | None | 1.35A | 5hgcA-5malA:undetectable | 5hgcA-5malA:18.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5my0 | FATTY ACID SYNTHASE (Mus musculus) |
no annotation | 5 | ALA B 182PHE B 148ILE B 90SER B 86PHE B 150 | None | 1.34A | 5hgcA-5my0B:undetectable | 5hgcA-5my0B:13.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5naq | BETA-GALACTOSIDASE (Lactobacillusplantarum) |
PF00232(Glyco_hydro_1) | 5 | PRO A 48ALA A 51ARG A 74GLN A 78SER A 76 | None | 0.93A | 5hgcA-5naqA:undetectable | 5hgcA-5naqA:20.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nij | VACUOLAR-PROCESSINGENZYME GAMMA-ISOZYME (Arabidopsisthaliana) |
no annotation | 5 | VAL A 125PHE A 173ILE A 79SER A 175ASN A 118 | NoneNoneNoneSNN A 176 ( 3.4A)None | 1.41A | 5hgcA-5nijA:undetectable | 5hgcA-5nijA:11.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t0l | BIFUNCTIONALDIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE (Toxoplasmagondii) |
PF00186(DHFR_1)PF00303(Thymidylat_synt) | 5 | PRO A 572ALA A 175THR A 30PHE A 245SER A 233 | None | 1.42A | 5hgcA-5t0lA:undetectable | 5hgcA-5t0lA:20.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tg8 | HEMAGGLUTININ HA1CHAIN (Influenza Avirus) |
PF00509(Hemagglutinin) | 5 | PRO A 215ALA A 250THR A 136PHE A 147ILE A 252 | None | 1.34A | 5hgcA-5tg8A:undetectable | 5hgcA-5tg8A:21.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v8w | INTEGRATOR COMPLEXSUBUNIT 9 (Homo sapiens) |
no annotation | 5 | VAL A 608THR A 597PHE A 654ILE A 589PHE A 594 | None | 1.40A | 5hgcA-5v8wA:undetectable | 5hgcA-5v8wA:15.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vtm | TYPE II SECRETIONSYSTEM PROTEIN K (Pseudomonasaeruginosa) |
no annotation | 5 | VAL X 226PRO X 225ALA X 228PHE X 250ILE X 241 | None | 1.42A | 5hgcA-5vtmX:undetectable | 5hgcA-5vtmX:13.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xxu | RIBOSOMAL PROTEINUS10RIBOSOMAL PROTEINUS14 (Toxoplasmagondii) |
PF00189(Ribosomal_S3_C)PF00338(Ribosomal_S10)PF07650(KH_2) | 5 | VAL d 21THR U 179PHE U 194GLN d 47PHE d 41 | None G 21194 ( 4.2A)NoneNoneNone | 1.37A | 5hgcA-5xxud:undetectable | 5hgcA-5xxud:8.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bdz | DISINTEGRIN ANDMETALLOPROTEINASEDOMAIN-CONTAININGPROTEIN 10 (Homo sapiens) |
no annotation | 5 | ALA A 315ARG A 321THR A 319PHE A 300GLN A 307 | NoneNoneNoneNoneNAG A 701 (-3.8A) | 1.41A | 5hgcA-6bdzA:undetectable | 5hgcA-6bdzA:11.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bq1 | PHOSPHATIDYLINOSITOL4-KINASE III ALPHA(PI4KA) (Homo sapiens) |
no annotation | 5 | ALA A2033THR A2053PHE A1980ILE A1864GLN A1863 | None | 1.34A | 5hgcA-6bq1A:undetectable | 5hgcA-6bq1A:0.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bym | STEROL-BINDINGPROTEIN (Saccharomycescerevisiae) |
no annotation | 5 | LYS A 167ILE A 170SER A 174PHE A 134ASN A 159 | NoneHC3 A 301 ( 4.1A)HC3 A 301 ( 3.3A)HC3 A 301 ( 4.6A)None | 1.30A | 5hgcA-6bymA:undetectable | 5hgcA-6bymA:11.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f8s | PUTATIVE KILLERPROTEINXRE FAMILYTRANSCRIPTIONALREGULATOR (Pseudomonasputida) |
no annotation | 5 | ALA B 34THR A 65ILE A 14PHE A 69ASN A 72 | None | 1.40A | 5hgcA-6f8sB:undetectable | 5hgcA-6f8sB:11.20 |