SIMILAR PATTERNS OF AMINO ACIDS FOR 5HGC_A_HCYA501

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e4e VANCOMYCIN/TEICOPLAN
IN A-TYPE RESISTANCE
PROTEIN VANA


(Enterococcus
faecium)
PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C)
5 VAL B 260
PRO B 261
ALA B 262
ILE B 272
GLN B 273
None
1.00A 5hgcA-1e4eB:
0.0
5hgcA-1e4eB:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g6o CAG-ALPHA

(Helicobacter
pylori)
PF00437
(T2SSE)
5 VAL A  58
THR A  32
PHE A  84
ILE A 130
PHE A  36
None
1.09A 5hgcA-1g6oA:
0.6
5hgcA-1g6oA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpe PROTEIN (GLUCOSE
OXIDASE)


(Penicillium
amagasakiense)
PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C)
5 PRO A 118
THR A 361
PHE A 414
ILE A 433
GLN A 559
None
1.39A 5hgcA-1gpeA:
0.0
5hgcA-1gpeA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gtk PORPHOBILINOGEN
DEAMINASE


(Escherichia
coli)
PF01379
(Porphobil_deam)
PF03900
(Porphobil_deamC)
5 VAL A  39
PRO A  40
ALA A   9
ARG A 211
ILE A  77
None
1.27A 5hgcA-1gtkA:
undetectable
5hgcA-1gtkA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iub FUCOSE-SPECIFIC
LECTIN


(Aleuria
aurantia)
PF07938
(Fungal_lectin)
5 ALA A  12
THR A 306
PHE A   4
ILE A  10
SER A   8
None
1.43A 5hgcA-1iubA:
undetectable
5hgcA-1iubA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j71 ASPARTIC PROTEINASE

(Candida
tropicalis)
PF00026
(Asp)
5 VAL A 310
ALA A 155
THR A   5
LYS A 153
ILE A 151
EOH  A 573 (-4.6A)
None
None
None
None
1.39A 5hgcA-1j71A:
0.0
5hgcA-1j71A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kuu CONSERVED PROTEIN

(Methanothermobacter)
PF07826
(IMP_cyclohyd)
5 ALA A 187
THR A 156
PHE A 176
ILE A 170
PHE A 158
None
1.34A 5hgcA-1kuuA:
0.7
5hgcA-1kuuA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lsh LIPOVITELLIN (LV-1N,
LV-1C)


(Ichthyomyzon
unicuspis)
PF01347
(Vitellogenin_N)
PF09172
(DUF1943)
5 PRO A 653
THR A 508
ILE A 647
GLN A 578
SER A 544
UPL  A2032 ( 4.6A)
None
None
None
None
1.26A 5hgcA-1lshA:
0.0
5hgcA-1lshA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n47 ISOLECTIN B4

(Vicia villosa)
PF00139
(Lectin_legB)
5 VAL A 189
ALA A 176
PHE A  73
ILE A 163
PHE A 124
None
1.37A 5hgcA-1n47A:
0.0
5hgcA-1n47A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o99 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE


(Geobacillus
stearothermophilus)
PF01676
(Metalloenzyme)
PF06415
(iPGM_N)
5 ALA A 201
PHE A 257
ILE A 268
GLN A 267
PHE A 149
None
1.03A 5hgcA-1o99A:
undetectable
5hgcA-1o99A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1obf GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE


(Achromobacter
xylosoxidans)
PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C)
5 PRO O  86
THR O  99
PHE O 102
GLN O  84
ASN O  35
None
1.38A 5hgcA-1obfO:
undetectable
5hgcA-1obfO:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE


(Escherichia
coli)
PF01156
(IU_nuc_hydro)
5 THR A 160
PHE A 168
ILE A  76
GLN A  74
PHE A 159
None
None
None
GOL  A3009 ( 3.5A)
GOL  A3005 (-4.9A)
1.25A 5hgcA-1q8fA:
undetectable
5hgcA-1q8fA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qrh ECO RI ENDONCULEASE

(Escherichia
coli)
PF02963
(EcoRI)
5 ALA A 139
THR A 239
ILE A 143
PHE A 174
ASN A 199
None
1.12A 5hgcA-1qrhA:
undetectable
5hgcA-1qrhA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r30 BIOTIN SYNTHASE

(Escherichia
coli)
PF04055
(Radical_SAM)
PF06968
(BATS)
5 VAL A 259
PHE A 305
ILE A 284
PHE A 277
ASN A 282
None
1.37A 5hgcA-1r30A:
undetectable
5hgcA-1r30A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqj OLIGOXYLOGLUCAN
REDUCING-END-SPECIFI
C CELLOBIOHYDROLASE


(Geotrichum sp.
M128)
PF15899
(BNR_6)
5 PRO A 368
ILE A 466
SER A 467
PHE A 372
ASN A 373
None
1.30A 5hgcA-1sqjA:
undetectable
5hgcA-1sqjA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t90 PROBABLE
METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE


(Bacillus
subtilis)
PF00171
(Aldedh)
5 VAL A 326
PRO A 325
ALA A 280
PHE A 384
ASN A 331
None
None
None
NAD  A1490 (-3.7A)
None
1.20A 5hgcA-1t90A:
undetectable
5hgcA-1t90A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1typ TRYPANOTHIONE
REDUCTASE


(Crithidia
fasciculata)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
5 PRO A 336
THR A 348
ILE A 325
SER A 315
ASN A 340
FAD  A 493 (-4.4A)
None
None
None
None
1.33A 5hgcA-1typA:
undetectable
5hgcA-1typA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vmi PUTATIVE PHOSPHATE
ACETYLTRANSFERASE


(Escherichia
coli)
PF01515
(PTA_PTB)
5 VAL A 318
ALA A 316
ILE A 312
GLN A 310
SER A 308
None
1.11A 5hgcA-1vmiA:
undetectable
5hgcA-1vmiA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aw5 NADP-DEPENDENT MALIC
ENZYME


(Homo sapiens)
PF00390
(malic)
PF03949
(Malic_M)
5 VAL A 276
ALA A 274
ARG A 155
ILE A 270
ASN A 454
None
1.44A 5hgcA-2aw5A:
undetectable
5hgcA-2aw5A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2azp HYPOTHETICAL PROTEIN
PA1268


(Pseudomonas
aeruginosa)
PF05544
(Pro_racemase)
5 VAL A 119
ALA A 121
PHE A 269
ILE A  93
ASN A 133
None
1.03A 5hgcA-2azpA:
undetectable
5hgcA-2azpA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2azp HYPOTHETICAL PROTEIN
PA1268


(Pseudomonas
aeruginosa)
PF05544
(Pro_racemase)
5 VAL A 119
ALA A 121
THR A 240
ILE A  93
ASN A 133
None
1.41A 5hgcA-2azpA:
undetectable
5hgcA-2azpA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpm PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1)


(Streptococcus
pneumoniae)
PF02086
(MethyltransfD12)
5 VAL A 115
ALA A 118
ILE A  74
SER A 163
ASN A  77
None
1.30A 5hgcA-2dpmA:
undetectable
5hgcA-2dpmA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ep7 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE


(Aquifex
aeolicus)
PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C)
5 PRO A  84
THR A  97
PHE A 100
GLN A  82
ASN A  33
None
NAD  A 401 (-4.0A)
NAD  A 401 (-4.7A)
None
NAD  A 401 (-4.2A)
1.33A 5hgcA-2ep7A:
undetectable
5hgcA-2ep7A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6a COLLAGEN ADHESIN

(Staphylococcus
aureus)
PF05737
(Collagen_bind)
5 PRO A  93
ALA A 104
THR A  55
ILE A 106
ASN A 322
None
1.21A 5hgcA-2f6aA:
undetectable
5hgcA-2f6aA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6a COLLAGEN ADHESIN

(Staphylococcus
aureus)
PF05737
(Collagen_bind)
5 PRO A  93
ALA A 104
THR A  55
ILE A 106
PHE A 131
None
1.34A 5hgcA-2f6aA:
undetectable
5hgcA-2f6aA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2np0 BOTULINUM NEUROTOXIN
TYPE B


(Clostridium
botulinum)
PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N)
5 VAL A 249
PRO A 250
ALA A 457
THR A 283
ILE A 278
None
1.25A 5hgcA-2np0A:
undetectable
5hgcA-2np0A:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o0y TRANSCRIPTIONAL
REGULATOR


(Rhodococcus sp.)
PF01614
(IclR)
PF09339
(HTH_IclR)
5 VAL A 126
ALA A 128
THR A 244
SER A 107
ASN A 115
None
1.29A 5hgcA-2o0yA:
undetectable
5hgcA-2o0yA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL


(Trypanosoma
brucei)
PF00342
(PGI)
5 VAL A 378
ALA A 374
ARG A 419
LYS A 549
SER A 561
None
1.32A 5hgcA-2o2cA:
undetectable
5hgcA-2o2cA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2psb YERB PROTEIN

(Bacillus
subtilis)
PF11258
(DUF3048)
PF17479
(DUF3048_C)
5 VAL A 278
PRO A 279
THR A 165
ILE A  54
PHE A  96
None
1.41A 5hgcA-2psbA:
undetectable
5hgcA-2psbA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvx 4-CHLOROBENZOATE COA
LIGASE


(Alcaligenes sp.
AL3007)
PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
5 VAL X 432
ALA X 446
THR X 423
PHE X 464
SER X 468
None
1.28A 5hgcA-2qvxX:
undetectable
5hgcA-2qvxX:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rc5 FERREDOXIN-NADP
REDUCTASE


(Leptospira
interrogans)
PF00175
(NAD_binding_1)
5 VAL A  26
ALA A  24
ILE A 112
SER A 100
PHE A 114
None
1.24A 5hgcA-2rc5A:
undetectable
5hgcA-2rc5A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rdy BH0842 PROTEIN

(Bacillus
halodurans)
PF14498
(Glyco_hyd_65N_2)
5 VAL A 433
PRO A  87
ALA A 431
PHE A 397
ASN A 423
None
1.45A 5hgcA-2rdyA:
undetectable
5hgcA-2rdyA:
19.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2v95 CORTICOSTEROID-BINDI
NG GLOBULIN


(Rattus
norvegicus)
PF00079
(Serpin)
5 PRO A  14
THR A 232
PHE A 234
ILE A 255
PHE A 357
HCY  A1375 (-3.4A)
HCY  A1375 ( 4.2A)
HCY  A1375 (-4.8A)
None
HCY  A1375 ( 4.1A)
0.54A 5hgcA-2v95A:
22.9
5hgcA-2v95A:
39.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpw HYPOTHETICAL
MEMBRANE SPANNING
PROTEIN
NRFC PROTEIN


(Thermus
thermophilus)
PF13247
(Fer4_11)
PF14589
(NrfD_2)
5 VAL B  85
PRO B  87
ALA B  74
ILE B  91
SER C  68
SF4  B1197 ( 4.8A)
None
SF4  B1197 ( 4.0A)
SF4  B1197 ( 4.3A)
MQ7  C1252 ( 4.9A)
1.24A 5hgcA-2vpwB:
undetectable
5hgcA-2vpwB:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x50 TRYPANOTHIONE
REDUCTASE


(Leishmania
infantum)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
5 PRO A 336
THR A 348
ILE A 325
SER A 315
ASN A 340
FAD  A1487 (-4.4A)
None
None
None
None
1.40A 5hgcA-2x50A:
undetectable
5hgcA-2x50A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsg CCMAN5

(Cellulosimicrobium
cellulans)
PF07971
(Glyco_hydro_92)
5 ALA A  98
THR A  63
LYS A  58
ILE A  59
GLN A  56
None
0.98A 5hgcA-2xsgA:
undetectable
5hgcA-2xsgA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ygl BLOOD GROUP A-AND
B-CLEAVING
ENDO-BETA-GALACTOSID
ASE


(Streptococcus
pneumoniae)
PF08305
(NPCBM)
5 ALA A 124
THR A 189
PHE A 185
ILE A 165
SER A 177
None
1.42A 5hgcA-2yglA:
undetectable
5hgcA-2yglA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yys PROLINE
IMINOPEPTIDASE-RELAT
ED PROTEIN


(Thermus
thermophilus)
PF12697
(Abhydrolase_6)
5 VAL A 277
PRO A 278
ALA A 275
PHE A 269
ILE A 123
None
1.44A 5hgcA-2yysA:
undetectable
5hgcA-2yysA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2znm THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBA


(Neisseria
meningitidis)
PF13462
(Thioredoxin_4)
5 ARG A 161
THR A 153
ILE A  16
GLN A 145
PHE A  29
None
1.32A 5hgcA-2znmA:
undetectable
5hgcA-2znmA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cdi POLYNUCLEOTIDE
PHOSPHORYLASE


(Escherichia
coli)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase)
5 PRO A 171
PHE A 130
ILE A 166
PHE A 126
ASN A 169
None
1.36A 5hgcA-3cdiA:
undetectable
5hgcA-3cdiA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dp7 SAM-DEPENDENT
METHYLTRANSFERASE


(Bacteroides
vulgatus)
PF00891
(Methyltransf_2)
5 VAL A  69
ALA A  67
THR A  79
PHE A  41
ILE A  40
None
1.44A 5hgcA-3dp7A:
undetectable
5hgcA-3dp7A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb7 INSECTICIDAL
DELTA-ENDOTOXIN
CRY8EA1


(Bacillus
thuringiensis)
PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N)
5 ALA A 519
ARG A 478
THR A 496
PHE A 342
ILE A 374
None
1.30A 5hgcA-3eb7A:
undetectable
5hgcA-3eb7A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5j 3-ISOPROPYLMALATE
DEHYDRATASE SMALL
SUBUNIT


(Mycobacterium
tuberculosis)
PF00694
(Aconitase_C)
5 VAL A 149
ALA A 146
ARG A  15
ILE A 127
GLN A 129
None
1.21A 5hgcA-3h5jA:
undetectable
5hgcA-3h5jA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6y ESTERASE APC40077

(Oleispira
antarctica)
PF00756
(Esterase)
5 VAL A  46
PRO A  47
ALA A  78
ILE A 132
PHE A 136
None
1.37A 5hgcA-3i6yA:
undetectable
5hgcA-3i6yA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jac PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1


(Mus musculus)
PF12166
(Piezo_RRas_bdg)
5 THR A2336
ILE A2448
GLN A2222
SER A2450
PHE A2323
None
1.37A 5hgcA-3jacA:
undetectable
5hgcA-3jacA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7n PUTATIVE
UNCHARACTERIZED
PROTEIN


(Streptococcus
mutans)
PF00117
(GATase)
5 VAL A  90
ALA A 175
PHE A 133
ILE A 166
GLN A 165
None
1.30A 5hgcA-3l7nA:
undetectable
5hgcA-3l7nA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0r RESPONSE REGULATOR

(Caulobacter
vibrioides)
PF00072
(Response_reg)
5 VAL A 151
PRO A 150
ALA A 153
ILE A 219
PHE A 242
None
1.17A 5hgcA-3n0rA:
undetectable
5hgcA-3n0rA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o65 PUTATIVE
ATAXIN-3-LIKE
PROTEIN


(Homo sapiens)
PF02099
(Josephin)
5 PHE A 127
LYS A   1
ILE A   5
PHE A 132
ASN A 133
None
1.34A 5hgcA-3o65A:
undetectable
5hgcA-3o65A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oo9 ABC TRANSPORTER
BINDING PROTEIN ACBH


(Actinoplanes
sp. SE50/110)
PF01547
(SBP_bac_1)
6 ALA A 258
PHE A 270
ILE A 342
GLN A 343
SER A 346
PHE A 134
SO4  A 409 ( 4.2A)
None
None
None
None
None
1.49A 5hgcA-3oo9A:
undetectable
5hgcA-3oo9A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ot2 UNCHARACTERIZED
PROTEIN


(Trichormus
variabilis)
PF05685
(Uma2)
5 ARG A  69
PHE A  14
ILE A  31
GLN A  33
SER A  24
BU1  A 189 ( 4.2A)
BU1  A 189 (-4.0A)
None
None
BU1  A 189 ( 4.2A)
1.33A 5hgcA-3ot2A:
undetectable
5hgcA-3ot2A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qjp PUTATIVE
UNCHARACTERIZED
PROTEIN PH0350


(Pyrococcus
horikoshii)
PF01881
(Cas_Cas6)
5 VAL A 109
PRO A  98
PHE A  52
ILE A  28
GLN A  27
None
1.36A 5hgcA-3qjpA:
undetectable
5hgcA-3qjpA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t57 UDP-N-ACETYLGLUCOSAM
INE
O-ACYLTRANSFERASE
DOMAIN-CONTAINING
PROTEIN


(Arabidopsis
thaliana)
PF00132
(Hexapep)
PF13720
(Acetyltransf_11)
5 VAL A 236
PRO A 237
ALA A 224
THR A 194
PHE A 190
None
1.41A 5hgcA-3t57A:
undetectable
5hgcA-3t57A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ty6 ATP-DEPENDENT
PROTEASE SUBUNIT
HSLV


(Bacillus
anthracis)
PF00227
(Proteasome)
5 VAL A 177
ALA A  19
ILE A 156
GLN A 155
PHE A  10
None
1.33A 5hgcA-3ty6A:
undetectable
5hgcA-3ty6A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u1k POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE 1, MITOCHONDRIAL


(Homo sapiens)
PF00013
(KH_1)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase)
5 ARG A 617
PHE A 647
ILE A 639
PHE A 620
ASN A 627
None
1.25A 5hgcA-3u1kA:
undetectable
5hgcA-3u1kA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ucq AMYLOSUCRASE

(Deinococcus
geothermalis)
PF00128
(Alpha-amylase)
5 PRO A 227
ILE A 221
GLN A 440
PHE A 248
ASN A 249
None
TRS  A 700 (-4.4A)
GOL  A 712 ( 3.6A)
GOL  A 720 (-4.2A)
GOL  A 711 (-3.6A)
1.03A 5hgcA-3ucqA:
undetectable
5hgcA-3ucqA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ufc PUTATIVE
UNCHARACTERIZED
PROTEIN


(Pyrococcus
furiosus)
PF01881
(Cas_Cas6)
5 VAL X 109
PRO X  98
PHE X  52
ILE X  28
GLN X  27
None
1.35A 5hgcA-3ufcX:
undetectable
5hgcA-3ufcX:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuq BOTULINUM NEUROTOXIN
TYPE B


(Clostridium
botulinum)
PF01742
(Peptidase_M27)
PF07952
(Toxin_trans)
5 VAL A 250
PRO A 251
ALA A 493
THR A 284
ILE A 279
None
1.35A 5hgcA-3zuqA:
undetectable
5hgcA-3zuqA:
18.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c41 CORTICOSTEROID-BINDI
NG GLOBULIN


(Homo sapiens)
PF00079
(Serpin)
5 THR A 240
PHE A 242
ILE A 263
SER A 267
PHE A 366
None
0.80A 5hgcA-4c41A:
45.2
5hgcA-4c41A:
41.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfi FLAGELLIN

(Burkholderia
pseudomallei)
PF00669
(Flagellin_N)
PF12613
(FliC_SP)
5 ALA A 259
THR A 239
PHE A 218
ILE A 206
PHE A 235
None
1.39A 5hgcA-4cfiA:
undetectable
5hgcA-4cfiA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4t PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT


(Burkholderia
ambifaria)
PF02222
(ATP-grasp)
5 VAL A 232
PRO A 233
ALA A 234
PHE A 266
GLN A 246
None
1.06A 5hgcA-4e4tA:
undetectable
5hgcA-4e4tA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL


(Homo sapiens)
PF00067
(p450)
5 PRO A 322
THR A 475
ILE A 481
SER A 494
PHE A 328
None
1.35A 5hgcA-4fdhA:
undetectable
5hgcA-4fdhA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzd SERINE/THREONINE-PRO
TEIN KINASE MST4


(Homo sapiens)
PF00069
(Pkinase)
5 PRO B 115
PHE B 273
ILE B 121
GLN B 120
PHE B 247
None
1.40A 5hgcA-4fzdB:
undetectable
5hgcA-4fzdB:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzd SERINE/THREONINE-PRO
TEIN KINASE MST4


(Homo sapiens)
PF00069
(Pkinase)
5 THR B 244
PHE B 273
ILE B 121
GLN B 120
PHE B 247
None
1.36A 5hgcA-4fzdB:
undetectable
5hgcA-4fzdB:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iox TRIPARTITE TERMINASE
SUBUNIT UL15


(Human
alphaherpesvirus
1)
PF02499
(DNA_pack_C)
5 VAL A 477
PRO A 476
PHE A 486
LYS A 480
PHE A 651
None
1.33A 5hgcA-4ioxA:
undetectable
5hgcA-4ioxA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4izo PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT


(Burkholderia
thailandensis)
PF02222
(ATP-grasp)
5 VAL A 232
PRO A 233
ALA A 234
PHE A 266
GLN A 246
None
0.99A 5hgcA-4izoA:
undetectable
5hgcA-4izoA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j9w PROLINE RACEMASE
FAMILY PROTEIN


(Pseudomonas
protegens)
PF05544
(Pro_racemase)
5 VAL A 119
ALA A 121
PHE A 269
ILE A  93
ASN A 133
None
None
GOL  A 404 (-4.7A)
None
None
1.01A 5hgcA-4j9wA:
undetectable
5hgcA-4j9wA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4li3 CYSTEINE SYNTHASE

(Haemophilus
influenzae)
PF00291
(PALP)
5 ALA X  76
THR X 156
ILE X  45
SER X 181
ASN X  36
LLP  X  42 ( 3.2A)
None
LLP  X  42 ( 4.0A)
LLP  X  42 ( 2.4A)
None
1.33A 5hgcA-4li3X:
undetectable
5hgcA-4li3X:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n40 PROTEIN ECT2

(Homo sapiens)
PF00533
(BRCT)
PF12738
(PTCB-BRCT)
5 VAL A 123
ALA A  68
ILE A  66
GLN A  62
PHE A  76
None
1.07A 5hgcA-4n40A:
undetectable
5hgcA-4n40A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9x TCDB2, TCCC3

(Photorhabdus
luminescens)
PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN)
5 VAL A 433
ALA A 699
ILE A 710
GLN A 695
SER A 712
None
1.28A 5hgcA-4o9xA:
undetectable
5hgcA-4o9xA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj6 LEUCYL-CYSTINYL
AMINOPEPTIDASE


(Homo sapiens)
PF01433
(Peptidase_M1)
PF11838
(ERAP1_C)
5 VAL A 194
THR A 292
LYS A 318
ILE A 319
SER A 329
None
1.28A 5hgcA-4pj6A:
undetectable
5hgcA-4pj6A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r84 SIALYLTRANSFERASE
0160


(Photobacterium
damselae)
PF11477
(PM0188)
5 VAL A 178
THR A 197
ILE A 210
GLN A 211
PHE A 195
None
1.39A 5hgcA-4r84A:
undetectable
5hgcA-4r84A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9v SIALYLTRANSFERASE
0160


(Photobacterium
damselae)
PF11477
(PM0188)
5 VAL A 178
THR A 197
ILE A 210
GLN A 211
PHE A 195
None
1.32A 5hgcA-4r9vA:
undetectable
5hgcA-4r9vA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u1f EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B


(Saccharomyces
cerevisiae)
PF08662
(eIF2A)
5 THR A 464
PHE A 462
ILE A 431
PHE A 453
ASN A 414
None
1.34A 5hgcA-4u1fA:
undetectable
5hgcA-4u1fA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uap GLYCOSYL HYDROLASE,
FAMILY
31/FIBRONECTIN TYPE
III DOMAIN PROTEIN


(Clostridium
perfringens)
no annotation 5 VAL A 116
PHE A  62
ILE A 127
PHE A 148
ASN A  70
None
1.39A 5hgcA-4uapA:
undetectable
5hgcA-4uapA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uer EIF3B

(Lachancea
kluyveri)
PF00318
(Ribosomal_S2)
5 THR b 530
PHE b 528
ILE b 497
PHE b 519
ASN b 480
None
1.35A 5hgcA-4uerb:
undetectable
5hgcA-4uerb:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v33 POLYSACCHARIDE
DEACETYLASE-LIKE
PROTEIN


(Bacillus
anthracis)
PF01522
(Polysacc_deac_1)
5 ALA A  89
PHE A 105
ILE A  79
GLN A 118
PHE A 110
None
1.06A 5hgcA-4v33A:
undetectable
5hgcA-4v33A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v33 POLYSACCHARIDE
DEACETYLASE-LIKE
PROTEIN


(Bacillus
anthracis)
PF01522
(Polysacc_deac_1)
5 ALA A  89
PHE A 105
LYS A  78
ILE A  79
PHE A 110
None
1.09A 5hgcA-4v33A:
undetectable
5hgcA-4v33A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xb3 GLUCAN
1,6-ALPHA-GLUCOSIDAS
E


(Streptococcus
mutans)
PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C)
5 VAL A 475
ALA A 477
THR A 514
PHE A 531
ASN A 492
None
1.41A 5hgcA-4xb3A:
undetectable
5hgcA-4xb3A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aa4 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE F


(Pseudomonas
aeruginosa)
PF00497
(SBP_bac_3)
PF01464
(SLT)
5 LYS B 352
ILE B 355
GLN B 356
SER B 359
PHE B 295
None
1.28A 5hgcA-5aa4B:
undetectable
5hgcA-5aa4B:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bwa ORNITHINE
DECARBOXYLASE


(Homo sapiens)
PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N)
5 VAL A 192
THR A  63
PHE A  65
ILE A 109
GLN A 129
None
1.29A 5hgcA-5bwaA:
undetectable
5hgcA-5bwaA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d0f UNCHARACTERIZED
PROTEIN


([Candida]
glabrata)
PF06202
(GDE_C)
PF14699
(hGDE_N)
PF14701
(hDGE_amylase)
PF14702
(hGDE_central)
5 VAL A  18
PRO A  17
THR A1029
ILE A  53
SER A  57
None
1.22A 5hgcA-5d0fA:
undetectable
5hgcA-5d0fA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ew5 COLICIN-E9

(Escherichia
coli)
PF03515
(Cloacin)
5 VAL A 230
PRO A 229
PHE A 275
ILE A 273
ASN A 232
None
1.39A 5hgcA-5ew5A:
undetectable
5hgcA-5ew5A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hqj PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR


(Paraburkholderia
graminis)
PF13407
(Peripla_BP_4)
5 VAL A 222
PRO A 225
ALA A 226
THR A 189
ILE A 216
CL  A 402 ( 4.4A)
CL  A 402 ( 4.9A)
None
None
None
1.41A 5hgcA-5hqjA:
undetectable
5hgcA-5hqjA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6c URIC ACID-XANTHINE
PERMEASE


(Aspergillus
nidulans)
PF00860
(Xan_ur_permease)
5 ALA A  89
THR A 404
SER A 127
PHE A 406
ASN A 409
None
XAN  A1001 (-4.7A)
None
XAN  A1001 (-3.5A)
None
1.44A 5hgcA-5i6cA:
undetectable
5hgcA-5i6cA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j90 RAGB/SUSD DOMAIN
PROTEIN


(Flavobacterium
johnsoniae)
PF12741
(SusD-like)
5 VAL A 115
ALA A 119
THR A 205
PHE A 202
PHE A  51
None
1.35A 5hgcA-5j90A:
undetectable
5hgcA-5j90A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mal LIPASE

(Streptomyces
rimosus)
PF13472
(Lipase_GDSL_2)
5 ARG A 104
THR A  89
ILE A 112
PHE A  86
ASN A  82
None
1.35A 5hgcA-5malA:
undetectable
5hgcA-5malA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5my0 FATTY ACID SYNTHASE

(Mus musculus)
no annotation 5 ALA B 182
PHE B 148
ILE B  90
SER B  86
PHE B 150
None
1.34A 5hgcA-5my0B:
undetectable
5hgcA-5my0B:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5naq BETA-GALACTOSIDASE

(Lactobacillus
plantarum)
PF00232
(Glyco_hydro_1)
5 PRO A  48
ALA A  51
ARG A  74
GLN A  78
SER A  76
None
0.93A 5hgcA-5naqA:
undetectable
5hgcA-5naqA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nij VACUOLAR-PROCESSING
ENZYME GAMMA-ISOZYME


(Arabidopsis
thaliana)
no annotation 5 VAL A 125
PHE A 173
ILE A  79
SER A 175
ASN A 118
None
None
None
SNN  A 176 ( 3.4A)
None
1.41A 5hgcA-5nijA:
undetectable
5hgcA-5nijA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t0l BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE


(Toxoplasma
gondii)
PF00186
(DHFR_1)
PF00303
(Thymidylat_synt)
5 PRO A 572
ALA A 175
THR A  30
PHE A 245
SER A 233
None
1.42A 5hgcA-5t0lA:
undetectable
5hgcA-5t0lA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tg8 HEMAGGLUTININ HA1
CHAIN


(Influenza A
virus)
PF00509
(Hemagglutinin)
5 PRO A 215
ALA A 250
THR A 136
PHE A 147
ILE A 252
None
1.34A 5hgcA-5tg8A:
undetectable
5hgcA-5tg8A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8w INTEGRATOR COMPLEX
SUBUNIT 9


(Homo sapiens)
no annotation 5 VAL A 608
THR A 597
PHE A 654
ILE A 589
PHE A 594
None
1.40A 5hgcA-5v8wA:
undetectable
5hgcA-5v8wA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vtm TYPE II SECRETION
SYSTEM PROTEIN K


(Pseudomonas
aeruginosa)
no annotation 5 VAL X 226
PRO X 225
ALA X 228
PHE X 250
ILE X 241
None
1.42A 5hgcA-5vtmX:
undetectable
5hgcA-5vtmX:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxu RIBOSOMAL PROTEIN
US10
RIBOSOMAL PROTEIN
US14


(Toxoplasma
gondii)
PF00189
(Ribosomal_S3_C)
PF00338
(Ribosomal_S10)
PF07650
(KH_2)
5 VAL d  21
THR U 179
PHE U 194
GLN d  47
PHE d  41
None
G  21194 ( 4.2A)
None
None
None
1.37A 5hgcA-5xxud:
undetectable
5hgcA-5xxud:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bdz DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 10


(Homo sapiens)
no annotation 5 ALA A 315
ARG A 321
THR A 319
PHE A 300
GLN A 307
None
None
None
None
NAG  A 701 (-3.8A)
1.41A 5hgcA-6bdzA:
undetectable
5hgcA-6bdzA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)


(Homo sapiens)
no annotation 5 ALA A2033
THR A2053
PHE A1980
ILE A1864
GLN A1863
None
1.34A 5hgcA-6bq1A:
undetectable
5hgcA-6bq1A:
0.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bym STEROL-BINDING
PROTEIN


(Saccharomyces
cerevisiae)
no annotation 5 LYS A 167
ILE A 170
SER A 174
PHE A 134
ASN A 159
None
HC3  A 301 ( 4.1A)
HC3  A 301 ( 3.3A)
HC3  A 301 ( 4.6A)
None
1.30A 5hgcA-6bymA:
undetectable
5hgcA-6bymA:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f8s PUTATIVE KILLER
PROTEIN
XRE FAMILY
TRANSCRIPTIONAL
REGULATOR


(Pseudomonas
putida)
no annotation 5 ALA B  34
THR A  65
ILE A  14
PHE A  69
ASN A  72
None
1.40A 5hgcA-6f8sB:
undetectable
5hgcA-6f8sB:
11.20