SIMILAR PATTERNS OF AMINO ACIDS FOR 5HFJ_H_SAMH301_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1boo PROTEIN (N-4
CYTOSINE-SPECIFIC
METHYLTRANSFERASE
PVU II)

(Proteus
vulgaris) 		PF01555
(N6_N4_Mtase) 		6 ASP A  34
PRO A  55
PHE A 273
GLY A 275
THR A 278
TYR A 299
 SAH  A 401 (-4.0A)
SAH  A 401 (-3.9A)
SAH  A 401 (-4.6A)
SAH  A 401 (-3.5A)
SAH  A 401 (-4.0A)
SAH  A 401 (-4.2A)
 0.53A 5hfjH-1booA:
19.7		 5hfjH-1booA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eye DIHYDROPTEROATE
SYNTHASE I

(Mycobacterium
tuberculosis) 		PF00809
(Pterin_bind) 		5 ASP A  27
ALA A  31
PRO A  71
GLY A  50
THR A  87
 None
 1.37A 5hfjH-1eyeA:
undetectable		 5hfjH-1eyeA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g60 ADENINE-SPECIFIC
METHYLTRANSFERASE
MBOIIA

(Moraxella bovis) 		PF01555
(N6_N4_Mtase) 		6 ASP A  30
LYS A 197
PHE A 220
GLY A 222
THR A 225
TYR A 246
 SAM  A 500 (-3.7A)
None
SAM  A 500 (-4.6A)
SAM  A 500 (-3.2A)
SAM  A 500 (-3.4A)
SAM  A 500 (-4.4A)
 0.68A 5hfjH-1g60A:
23.1		 5hfjH-1g60A:
29.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g60 ADENINE-SPECIFIC
METHYLTRANSFERASE
MBOIIA

(Moraxella bovis) 		PF01555
(N6_N4_Mtase) 		6 ASP A  30
PRO A  32
LYS A 197
PHE A 220
GLY A 222
THR A 225
 SAM  A 500 (-3.7A)
None
None
SAM  A 500 (-4.6A)
SAM  A 500 (-3.2A)
SAM  A 500 (-3.4A)
 0.66A 5hfjH-1g60A:
23.1		 5hfjH-1g60A:
29.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ne2 HYPOTHETICAL PROTEIN
TA1320

(Thermoplasma
acidophilum) 		PF06325
(PrmA) 		5 ASP A 100
ALA A  99
ASP A  54
PHE A  77
GLY A  58
 None
 1.35A 5hfjH-1ne2A:
4.7		 5hfjH-1ne2A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nku 3-METHYLADENINE DNA
GLYCOSYLASE I (TAG)

(Escherichia
coli) 		PF03352
(Adenine_glyco) 		5 ALA A 148
ASP A 114
PHE A 115
THR A  26
TYR A 102
 None
 1.32A 5hfjH-1nkuA:
undetectable		 5hfjH-1nkuA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nw5 MODIFICATION
METHYLASE RSRI

(Rhodobacter
sphaeroides) 		PF01555
(N6_N4_Mtase) 		7 ASP A  46
ASP A  65
PRO A  67
THR A 225
LYS A 227
PHE A 250
GLY A 252
 SAM  A 401 (-3.6A)
SAM  A 401 (-3.3A)
SAM  A 401 (-4.3A)
SAM  A 401 (-3.6A)
SAM  A 401 (-4.4A)
SAM  A 401 (-4.7A)
SAM  A 401 (-3.3A)
 0.63A 5hfjH-1nw5A:
20.4		 5hfjH-1nw5A:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nw5 MODIFICATION
METHYLASE RSRI

(Rhodobacter
sphaeroides) 		PF01555
(N6_N4_Mtase) 		7 ASP A  46
ASP A  65
THR A 225
GLN A 226
LYS A 227
PHE A 250
GLY A 252
 SAM  A 401 (-3.6A)
SAM  A 401 (-3.3A)
SAM  A 401 (-3.6A)
None
SAM  A 401 (-4.4A)
SAM  A 401 (-4.7A)
SAM  A 401 (-3.3A)
 0.69A 5hfjH-1nw5A:
20.4		 5hfjH-1nw5A:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nw5 MODIFICATION
METHYLASE RSRI

(Rhodobacter
sphaeroides) 		PF01555
(N6_N4_Mtase) 		5 ASP A  65
THR A 225
LYS A 227
GLY A 252
TYR A 279
 SAM  A 401 (-3.3A)
SAM  A 401 (-3.6A)
SAM  A 401 (-4.4A)
SAM  A 401 (-3.3A)
None
 1.39A 5hfjH-1nw5A:
20.4		 5hfjH-1nw5A:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odf HYPOTHETICAL 33.3
KDA PROTEIN IN
ADE3-SER2 INTERGENIC
REGION

(Saccharomyces
cerevisiae) 		no annotation 5 ALA A  68
ASP A 103
THR A  76
GLN A  80
PHE A  73
 None
 1.33A 5hfjH-1odfA:
undetectable		 5hfjH-1odfA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t8w AMP NUCLEOSIDASE

(Escherichia
coli) 		PF01048
(PNP_UDP_1)
PF10423
(AMNp_N) 		5 ALA A  27
PRO A 147
PHE A  52
THR A  86
TYR A 125
 None
 1.31A 5hfjH-1t8wA:
undetectable		 5hfjH-1t8wA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tkc TRANSKETOLASE

(Saccharomyces
cerevisiae) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 ALA A 420
THR A 384
GLY A 440
THR A 468
TYR A 438
 None
 1.30A 5hfjH-1tkcA:
undetectable		 5hfjH-1tkcA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tvz 3-HYDROXY-3-METHYLGL
UTARYL-COA SYNTHASE

(Staphylococcus
aureus) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		5 ALA A 204
THR A 152
GLN A  39
THR A 237
SER A 307
 None
 1.33A 5hfjH-1tvzA:
undetectable		 5hfjH-1tvzA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v02 DHURRINASE

(Sorghum bicolor) 		PF00232
(Glyco_hydro_1) 		5 ASP A 281
ASP A 386
LYS A 382
GLY A 262
SER A 279
 None
 1.24A 5hfjH-1v02A:
undetectable		 5hfjH-1v02A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vf8 SECRETORY PROTEIN

(Mus musculus) 		PF00704
(Glyco_hydro_18) 		5 ASP A 198
ASP A 316
PRO A 206
GLY A 314
TYR A 305
 None
 1.23A 5hfjH-1vf8A:
undetectable		 5hfjH-1vf8A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w7c LYSYL OXIDASE

(Komagataella
pastoris) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF09248
(DUF1965) 		5 ASP A 479
THR A 426
PHE A 407
THR A 423
SER A 473
 TPQ  A 478 ( 3.8A)
None
None
NAG  A1786 (-3.0A)
None
 1.36A 5hfjH-1w7cA:
undetectable		 5hfjH-1w7cA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xr5 GENOME POLYPROTEIN

(Rhinovirus B) 		PF00680
(RdRP_1) 		5 PRO A 153
GLY A 117
THR A 114
SER A 122
TYR A 120
 None
 1.31A 5hfjH-1xr5A:
undetectable		 5hfjH-1xr5A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xvy SFUA

(Yersinia
enterocolitica) 		PF13343
(SBP_bac_6) 		5 ASP A 290
ALA A 292
GLN A 255
GLY A  97
TYR A  88
 None
 1.25A 5hfjH-1xvyA:
undetectable		 5hfjH-1xvyA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yfj DNA ADENINE
METHYLASE

(Escherichia
virus T4) 		PF02086
(MethyltransfD12) 		5 ASP A 171
PRO A 173
LYS A  11
PHE A  32
GLY A  34
 SAH  A 401 (-3.8A)
SAH  A 401 (-4.0A)
SAH  A 401 (-4.8A)
SAH  A 401 (-4.2A)
SAH  A 401 (-3.2A)
 0.75A 5hfjH-1yfjA:
2.3		 5hfjH-1yfjA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aco OUTER MEMBRANE
LIPOPROTEIN BLC

(Escherichia
coli) 		PF08212
(Lipocalin_2) 		5 ASP A  35
ALA A  36
LYS A  19
PHE A  95
THR A  23
 None
 1.39A 5hfjH-2acoA:
undetectable		 5hfjH-2acoA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpm PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1)

(Streptococcus
pneumoniae) 		PF02086
(MethyltransfD12) 		6 ASP A 177
ASP A 194
PRO A 196
LYS A  21
PHE A  43
GLY A  45
 SAM  A 300 (-4.1A)
SAM  A 300 (-3.7A)
SAM  A 300 ( 4.1A)
SAM  A 300 (-4.8A)
SAM  A 300 (-4.2A)
SAM  A 300 (-3.6A)
 1.21A 5hfjH-2dpmA:
3.9		 5hfjH-2dpmA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2esr METHYLTRANSFERASE

(Streptococcus
pyogenes) 		PF03602
(Cons_hypoth95) 		5 ALA A 100
ASP A 117
PRO A 119
PHE A  49
GLY A  51
 None
 0.74A 5hfjH-2esrA:
4.5		 5hfjH-2esrA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fhp METHYLASE, PUTATIVE

(Enterococcus
faecalis) 		PF03602
(Cons_hypoth95) 		5 ASP A  99
ALA A 100
ASP A 120
PRO A 122
GLY A  51
 None
 0.89A 5hfjH-2fhpA:
6.4		 5hfjH-2fhpA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fpo METHYLASE YHHF

(Escherichia
coli) 		PF03602
(Cons_hypoth95) 		5 ALA A 110
ASP A 127
PRO A 129
PHE A  60
GLY A  62
 CL  A 401 (-3.8A)
None
None
None
None
 0.92A 5hfjH-2fpoA:
4.4		 5hfjH-2fpoA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iou PERTACTIN
EXTRACELLULAR DOMAIN

(Bordetella
bronchiseptica) 		PF03212
(Pertactin) 		5 ASP G 297
ALA G 247
PHE G 226
GLY G 251
SER G 299
 None
 1.24A 5hfjH-2iouG:
undetectable		 5hfjH-2iouG:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjq UNCHARACTERIZED RNA
METHYLTRANSFERASE
PYRAB10780

(Pyrococcus
abyssi) 		PF05958
(tRNA_U5-meth_tr) 		5 ASP A 340
PRO A 342
GLY A 280
THR A 283
SER A 300
 SAH  A1406 (-3.8A)
SAH  A1406 (-4.1A)
SAH  A1406 (-3.4A)
SAH  A1406 (-3.4A)
SAH  A1406 (-2.9A)
 0.88A 5hfjH-2jjqA:
3.5		 5hfjH-2jjqA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ker ALPHA-AMYLASE
INHIBITOR Z-2685

(Streptomyces
parvulus) 		PF01356
(A_amylase_inhib) 		5 ALA A  41
ASP A  20
PHE A  54
GLY A  56
TYR A  63
 None
 0.98A 5hfjH-2kerA:
undetectable		 5hfjH-2kerA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r25 OSMOSENSING
HISTIDINE PROTEIN
KINASE SLN1

(Saccharomyces
cerevisiae) 		PF00072
(Response_reg) 		5 ASP B1177
ALA B1176
ASP B1151
THR B1156
SER B1179
 None
 1.38A 5hfjH-2r25B:
2.7		 5hfjH-2r25B:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7z HEAT SHOCK COGNATE
71 KDA PROTEIN

(Rattus
norvegicus) 		PF00012
(HSP70) 		5 ALA A 179
ASP A 366
PRO A 365
GLY A 201
THR A  14
 None
ADP  A1383 ( 4.9A)
None
ADP  A1383 (-3.6A)
ADP  A1383 (-3.7A)
 1.33A 5hfjH-2v7zA:
undetectable		 5hfjH-2v7zA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9y PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Homo sapiens) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 ASP A 478
ALA A 482
PRO A 487
GLN A 527
GLY A 591
 None
 0.94A 5hfjH-2v9yA:
undetectable		 5hfjH-2v9yA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vro ALDEHYDE
DEHYDROGENASE

(Paraburkholderia
xenovorans) 		PF00171
(Aldedh) 		5 ALA A 152
PRO A 171
THR A 108
GLY A 164
SER A 230
 None
 1.40A 5hfjH-2vroA:
3.5		 5hfjH-2vroA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wb7 PT26-6P

(Thermococcus
sp. 26-2) 		no annotation 5 ALA A 625
GLY A 633
THR A 532
SER A 662
TYR A 636
 None
 1.37A 5hfjH-2wb7A:
undetectable		 5hfjH-2wb7A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wjs LAMININ SUBUNIT
ALPHA-2

(Mus musculus) 		PF00054
(Laminin_G_1) 		5 ASP A2288
ALA A2287
ASP A2268
GLY A2207
THR A2265
 None
None
CA  A5001 (-3.2A)
CA  A5001 ( 4.3A)
None
 1.28A 5hfjH-2wjsA:
undetectable		 5hfjH-2wjsA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3c TOXIC EXTRACELLULAR
ENDOPEPTIDASE

(Aeromonas
salmonicida) 		PF14521
(Aspzincin_M35) 		5 ASP A 241
ALA A 242
ASP A 194
GLY A 198
THR A 282
 None
 1.20A 5hfjH-2x3cA:
undetectable		 5hfjH-2x3cA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zie PUTATIVE
MODIFICATION
METHYLASE

(Thermus
thermophilus) 		PF01555
(N6_N4_Mtase) 		7 ASP A  28
ALA A  29
PRO A  49
PHE A 243
GLY A 245
THR A 248
TYR A 269
 None
 0.72A 5hfjH-2zieA:
20.1		 5hfjH-2zieA:
26.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a21 PUTATIVE SECRETED
ALPHA-GALACTOSIDASE

(Streptomyces
avermitilis) 		PF00652
(Ricin_B_lectin)
PF16499
(Melibiase_2) 		5 ASP A 196
ALA A 198
THR A 552
GLN A 266
GLY A 227
 None
 1.34A 5hfjH-3a21A:
undetectable		 5hfjH-3a21A:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a21 PUTATIVE SECRETED
ALPHA-GALACTOSIDASE

(Streptomyces
avermitilis) 		PF00652
(Ricin_B_lectin)
PF16499
(Melibiase_2) 		5 ASP A 196
THR A 552
GLN A 266
GLY A 227
TYR A 228
 None
 1.40A 5hfjH-3a21A:
undetectable		 5hfjH-3a21A:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5r BENZALACETONE
SYNTHASE

(Rheum palmatum) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 ALA A 213
GLY A 161
THR A 235
SER A 332
TYR A 158
 None
 1.26A 5hfjH-3a5rA:
undetectable		 5hfjH-3a5rA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT

(Methanosarcina
barkeri) 		PF03063
(Prismane) 		5 ASP A 618
ASP A 718
PRO A 716
GLY A 625
THR A 514
 GOL  A 825 ( 4.8A)
None
None
None
None
 1.25A 5hfjH-3cf4A:
2.1		 5hfjH-3cf4A:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gip N-ACYL-D-GLUTAMATE
DEACYLASE

(Bordetella
bronchiseptica) 		PF07969
(Amidohydro_3) 		5 ASP A 438
ALA A 440
ASP A 370
GLY A 366
SER A 380
 None
 1.32A 5hfjH-3gipA:
undetectable		 5hfjH-3gipA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h84 ATPASE GET3

(Saccharomyces
cerevisiae) 		PF02374
(ArsA_ATPase) 		5 ASP A 128
ALA A 127
THR A 182
GLN A 178
GLY A 135
 None
 1.29A 5hfjH-3h84A:
undetectable		 5hfjH-3h84A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i2w SYNDAPIN

(Drosophila
melanogaster) 		PF00611
(FCH) 		5 ASP A 223
ALA A 139
ASP A 131
LYS A 127
SER A 226
 None
 1.39A 5hfjH-3i2wA:
undetectable		 5hfjH-3i2wA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7i TEICHOIC ACID
BIOSYNTHESIS PROTEIN
F

(Staphylococcus
epidermidis) 		PF04464
(Glyphos_transf) 		5 ASP A 661
ASP A 629
PHE A 628
GLY A 631
TYR A 695
 None
 1.15A 5hfjH-3l7iA:
undetectable		 5hfjH-3l7iA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldu PUTATIVE METHYLASE

(Clostridioides
difficile) 		PF01170
(UPF0020)
PF02926
(THUMP) 		5 ASP A 289
ALA A 290
PRO A 307
GLY A 202
THR A 205
 GTP  A 383 ( 3.8A)
GTP  A 383 (-3.7A)
GTP  A 383 (-3.7A)
GTP  A 383 (-2.6A)
GTP  A 383 (-3.5A)
 0.54A 5hfjH-3lduA:
2.1		 5hfjH-3lduA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus) 		PF00365
(PFK) 		5 ALA A 683
THR A 704
PHE A 720
GLY A 708
THR A 724
 None
 1.36A 5hfjH-3o8lA:
2.2		 5hfjH-3o8lA:
15.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3od1 ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT

(Bacillus
halodurans) 		PF13393
(tRNA-synt_His) 		5 ASP A 265
ASP A 139
THR A 311
GLY A 277
TYR A 275
 None
 1.39A 5hfjH-3od1A:
undetectable		 5hfjH-3od1A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxl LACCASE

(Trametes
hirsuta) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 ALA A 468
PRO A 446
GLN A 102
GLY A 401
THR A 403
 None
 1.23A 5hfjH-3pxlA:
undetectable		 5hfjH-3pxlA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pz6 LEUCYL-TRNA
SYNTHETASE

(Giardia
intestinalis) 		PF00133
(tRNA-synt_1) 		5 ASP A 543
PRO A 339
THR A 435
GLY A 263
THR A 431
 None
 1.34A 5hfjH-3pz6A:
undetectable		 5hfjH-3pz6A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qvm OLEI00960

(Oleispira
antarctica) 		PF00561
(Abhydrolase_1) 		5 ASP A  60
GLY A  63
THR A 192
SER A  71
TYR A  77
 None
 1.29A 5hfjH-3qvmA:
undetectable		 5hfjH-3qvmA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tm5 CRYSTAL STRUCTURE OF
TRM14

(Pyrococcus
furiosus) 		PF01170
(UPF0020)
PF02926
(THUMP) 		5 ASP A 276
ALA A 277
PRO A 295
GLY A 227
THR A 230
 SFG  A 401 (-3.4A)
SFG  A 401 (-3.1A)
SFG  A 401 ( 4.4A)
SFG  A 401 ( 3.7A)
SFG  A 401 (-3.3A)
 0.66A 5hfjH-3tm5A:
4.0		 5hfjH-3tm5A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tma METHYLTRANSFERASE

(Thermus
thermophilus) 		PF01170
(UPF0020)
PF02926
(THUMP) 		6 ASP A 243
ALA A 244
PRO A 262
PHE A 192
GLY A 194
THR A 197
 None
 0.76A 5hfjH-3tmaA:
4.3		 5hfjH-3tmaA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4p INTEGRIN ALPHA-4

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		5 ASP A 375
ALA A 374
ASP A 344
GLN A 404
PHE A 350
 None
None
CA  A 602 (-3.9A)
None
None
 1.29A 5hfjH-3v4pA:
undetectable		 5hfjH-3v4pA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8v RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L

(Escherichia
coli) 		PF01170
(UPF0020)
PF02926
(THUMP)
PF10672
(Methyltrans_SAM) 		5 ASP A 597
ASP A 615
PRO A 617
PHE A 546
TYR A 573
 SAM  A 802 (-3.5A)
None
SAM  A 802 ( 4.6A)
SAM  A 802 (-4.5A)
SAM  A 802 (-4.6A)
 0.94A 5hfjH-3v8vA:
4.7		 5hfjH-3v8vA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ve2 TRANSFERRIN-BINDING
PROTEIN 2

(Neisseria
meningitidis) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		5 ASP A 579
PRO A 537
THR A 531
GLY A 604
THR A 379
 None
 1.38A 5hfjH-3ve2A:
undetectable		 5hfjH-3ve2A:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zsc PECTATE
TRISACCHARIDE-LYASE

(Thermotoga
maritima) 		PF00544
(Pec_lyase_C) 		5 ASP A 139
LYS A 163
PHE A 116
GLY A 137
TYR A 104
 AQA  A1338 (-3.9A)
AQA  A1338 (-3.0A)
None
None
None
 1.05A 5hfjH-3zscA:
undetectable		 5hfjH-3zscA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a22 FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Mycobacterium
tuberculosis) 		PF01116
(F_bP_aldolase) 		5 ALA A  37
ASP A  47
THR A 343
PHE A  41
THR A   5
 None
 1.29A 5hfjH-4a22A:
undetectable		 5hfjH-4a22A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b4d FERREDOXIN-NADP
REDUCTASE

(Xanthomonas
citri) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		5 ASP A 211
ALA A 213
GLY A 248
THR A 246
TYR A 250
 None
 1.11A 5hfjH-4b4dA:
2.5		 5hfjH-4b4dA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dnx SULFATE
ADENYLYLTRANSFERASE

(Allochromatium
vinosum) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		5 ASP A 316
ALA A 317
PRO A 274
GLY A 137
THR A 132
 None
 1.19A 5hfjH-4dnxA:
undetectable		 5hfjH-4dnxA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e77 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Yersinia pestis) 		PF00202
(Aminotran_3) 		5 ALA A 285
ASP A 259
GLN A 251
GLY A 278
THR A 105
 None
 1.37A 5hfjH-4e77A:
undetectable		 5hfjH-4e77A:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fix UDP-GALACTOFURANOSYL
TRANSFERASE GLFT2

(Mycobacterium
tuberculosis) 		PF13641
(Glyco_tranf_2_3) 		5 ASP A 199
LYS A 369
PHE A 169
GLY A 232
TYR A 236
 None
 1.37A 5hfjH-4fixA:
undetectable		 5hfjH-4fixA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fsf PENICILLIN-BINDING
PROTEIN 3

(Pseudomonas
aeruginosa) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 ALA A 363
PRO A 392
GLY A 408
THR A 295
TYR A 409
 None
None
None
None
0W0  A 601 (-4.7A)
 1.00A 5hfjH-4fsfA:
undetectable		 5hfjH-4fsfA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hb9 SIMILARITIES WITH
PROBABLE
MONOOXYGENASE

(Photorhabdus
laumondii) 		PF01494
(FAD_binding_3) 		5 ASP A 268
ALA A 265
PRO A 255
PHE A 261
TYR A 247
 None
 1.36A 5hfjH-4hb9A:
undetectable		 5hfjH-4hb9A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k35 GLYCOSIDE HYDROLASE
FAMILY 81
ENDO-BETA-1,3-GLUCAN
ASE

(Rhizomucor
miehei) 		PF03639
(Glyco_hydro_81) 		5 ASP A 512
ASP A 384
GLY A 389
THR A 380
TYR A 482
 None
 1.40A 5hfjH-4k35A:
undetectable		 5hfjH-4k35A:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nfu EDS1

(Arabidopsis
thaliana) 		PF01764
(Lipase_3) 		5 ALA A  88
PRO A 159
THR A 155
PHE A  89
THR A 133
 None
 1.09A 5hfjH-4nfuA:
undetectable		 5hfjH-4nfuA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3o MGS-MT1

(unidentified) 		PF07859
(Abhydrolase_3) 		5 ASP A 241
ASP A 226
PHE A 292
GLY A 231
TYR A 235
 None
 1.33A 5hfjH-4q3oA:
undetectable		 5hfjH-4q3oA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r04 TOXIN A

(Clostridioides
difficile) 		PF11713
(Peptidase_C80)
PF12918
(TcdB_N)
PF12919
(TcdA_TcdB)
PF12920
(TcdA_TcdB_pore) 		5 ASP A 590
THR A 554
GLN A 611
PHE A 550
GLY A 588
 None
 1.14A 5hfjH-4r04A:
undetectable		 5hfjH-4r04A:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r27 GLYCOSIDE HYDROLASE

(Microbacterium
sp. Gsoil167) 		PF00232
(Glyco_hydro_1) 		5 ASP A 362
ALA A 365
THR A  81
PHE A  19
GLY A 376
 None
 1.38A 5hfjH-4r27A:
undetectable		 5hfjH-4r27A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rv3 1-PHOSPHATIDYLINOSIT
OL PHOSPHODIESTERASE

(Staphylococcus
aureus) 		PF00388
(PI-PLC-X) 		5 ASP A  65
ASP A  50
GLY A 284
THR A 286
SER A  29
 None
 1.39A 5hfjH-4rv3A:
undetectable		 5hfjH-4rv3A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u7t DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A

(Homo sapiens) 		PF00145
(DNA_methylase) 		5 ASP A 686
PRO A 709
PHE A 640
GLY A 642
THR A 645
 SAH  A1004 (-3.0A)
SAH  A1004 ( 3.9A)
SAH  A1004 (-4.6A)
SAH  A1004 (-3.3A)
SAH  A1004 (-3.3A)
 0.54A 5hfjH-4u7tA:
2.1		 5hfjH-4u7tA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uoz BETA-GALACTOSIDASE

(Bifidobacterium
animalis) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		5 ASP A 562
ALA A 561
ASP A 586
PHE A 577
GLY A 584
 None
 1.28A 5hfjH-4uozA:
undetectable		 5hfjH-4uozA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x2r 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE

(Actinomyces
urogenitalis) 		PF00977
(His_biosynth) 		5 ASP A  53
ALA A  11
THR A 164
GLY A  21
THR A 171
 None
 1.28A 5hfjH-4x2rA:
undetectable		 5hfjH-4x2rA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xqk LLABIII

(Lactococcus
lactis) 		PF00271
(Helicase_C)
PF02384
(N6_Mtase)
PF04851
(ResIII)
PF13156
(Mrr_cat_2) 		5 ASP A 981
PRO A1020
PHE A 904
GLY A 906
THR A 909
 None
 0.76A 5hfjH-4xqkA:
3.4		 5hfjH-4xqkA:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y2w ALANINE RACEMASE 1

(Caldanaerobacter
subterraneus) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 ASP A 353
ALA A 352
GLY A 339
THR A 251
SER A 350
 None
 1.26A 5hfjH-4y2wA:
undetectable		 5hfjH-4y2wA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zcf RESTRICTION
ENDONUCLEASE
ECOP15I,
MODIFICATION SUBUNIT

(Escherichia
coli) 		PF01555
(N6_N4_Mtase) 		7 ASP A 101
ASP A 123
PRO A 125
LYS A 418
PHE A 441
GLY A 443
THR A 446
 None
 0.87A 5hfjH-4zcfA:
18.7		 5hfjH-4zcfA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr5 NEPRILYSIN

(Oryctolagus
cuniculus) 		PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N) 		5 ASP A 632
PRO A 714
THR A 644
PHE A 717
GLY A 627
 None
 1.40A 5hfjH-4zr5A:
undetectable		 5hfjH-4zr5A:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bwi GLYCOSIDE HYDROLASE
FAMILY 79

(Burkholderia
pseudomallei) 		PF12891
(Glyco_hydro_44) 		5 ASP A 377
ASP A 444
PHE A 445
GLY A 358
SER A 380
 None
 1.40A 5hfjH-5bwiA:
undetectable		 5hfjH-5bwiA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c1m MU-TYPE OPIOID
RECEPTOR
NANOBODY 39

(Mus musculus;
Lama glama) 		PF00001
(7tm_1)
PF07686
(V-set) 		5 ASP A 340
THR A 103
THR A  97
SER B  50
TYR B  60
 None
 1.31A 5hfjH-5c1mA:
undetectable		 5hfjH-5c1mA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dkv ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)

(Agrobacterium
vitis) 		PF13407
(Peripla_BP_4) 		5 ASP A 181
ASP A  72
THR A  77
GLY A  40
THR A  42
 None
 1.22A 5hfjH-5dkvA:
3.4		 5hfjH-5dkvA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dqr 7-HYDROXYMETHYL
CHLOROPHYLL A
REDUCTASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF04422
(FrhB_FdhB_N)
PF04432
(FrhB_FdhB_C) 		5 ASP A 105
ALA A 104
THR A 306
THR A 418
SER A 106
 None
 1.39A 5hfjH-5dqrA:
undetectable		 5hfjH-5dqrA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e72 N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE

(Thermococcus
kodakarensis) 		PF01170
(UPF0020)
PF02926
(THUMP) 		6 ASP A 235
ALA A 236
ASP A 254
PRO A 256
PHE A 187
GLY A 189
 SAM  A 400 (-3.4A)
SAM  A 400 (-3.5A)
None
SAM  A 400 (-4.2A)
SAM  A 400 (-4.7A)
SAM  A 400 (-3.3A)
 0.66A 5hfjH-5e72A:
5.5		 5hfjH-5e72A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eb5 HNL ISOENZYME 5

(Prunus dulcis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 ASP A 487
ALA A 488
THR A 187
GLY A 501
SER A  37
 FAD  A 601 (-4.6A)
FAD  A 601 (-3.2A)
None
None
FAD  A 601 (-4.4A)
 1.32A 5hfjH-5eb5A:
undetectable		 5hfjH-5eb5A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eoe BETA-LACTAMASE

(Pseudomonas
aeruginosa) 		PF13354
(Beta-lactamase2) 		5 ASP A 124
ALA A 128
PRO A 160
THR A 164
THR A 173
 None
 1.29A 5hfjH-5eoeA:
undetectable		 5hfjH-5eoeA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fkc BETA-FRUCTOFURANOSID
ASE

(Xanthophyllomyces
dendrorhous) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		5 ALA A 112
PRO A  81
THR A 304
GLY A 147
THR A 163
 None
None
FRU  A3001 ( 4.9A)
None
None
 1.12A 5hfjH-5fkcA:
undetectable		 5hfjH-5fkcA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gn5 GLYCEROL KINASE

(Trypanosoma
brucei) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 ASP A   8
ALA A 451
ASP A  20
PRO A  25
PHE A  19
 None
 1.40A 5hfjH-5gn5A:
undetectable		 5hfjH-5gn5A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h05 AMYP

(marine
metagenome) 		PF00128
(Alpha-amylase) 		5 ALA A 259
GLN A  17
PHE A 301
GLY A 294
THR A 337
 None
 1.22A 5hfjH-5h05A:
undetectable		 5hfjH-5h05A:
16.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hfj ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA)

(Helicobacter
pylori) 		PF01555
(N6_N4_Mtase) 		7 ALA A   9
ASP A  29
PRO A  31
PHE A 195
GLY A 197
THR A 200
SER A 217
 SAM  A 301 (-3.2A)
SAM  A 301 (-3.2A)
SAM  A 301 ( 4.0A)
SAM  A 301 (-4.6A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.6A)
SAM  A 301 (-2.8A)
 0.66A 5hfjH-5hfjA:
33.2		 5hfjH-5hfjA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hfj ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA)

(Helicobacter
pylori) 		PF01555
(N6_N4_Mtase) 		8 ASP A   8
ALA A   9
ASP A  29
PRO A  31
PHE A 195
GLY A 197
THR A 200
TYR A 221
 SAM  A 301 (-3.4A)
SAM  A 301 (-3.2A)
SAM  A 301 (-3.2A)
SAM  A 301 ( 4.0A)
SAM  A 301 (-4.6A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.6A)
SAM  A 301 (-4.2A)
 0.37A 5hfjH-5hfjA:
33.2		 5hfjH-5hfjA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i51 TRANSKETOLASE

(Scheffersomyces
stipitis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 ALA A 417
THR A 381
GLY A 437
THR A 465
TYR A 435
 None
 1.29A 5hfjH-5i51A:
undetectable		 5hfjH-5i51A:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijx TYROSINE--TRNA
LIGASE,
MITOCHONDRIAL

(Coccidioides
posadasii) 		PF00579
(tRNA-synt_1b) 		5 ALA A 297
PRO A 263
THR A 160
PHE A 293
GLY A 289
 None
 1.41A 5hfjH-5ijxA:
2.9		 5hfjH-5ijxA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jkp UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF08238
(Sel1) 		5 ASP A 138
ALA A 136
ASP A 121
PHE A 119
GLY A 123
 None
 1.29A 5hfjH-5jkpA:
undetectable		 5hfjH-5jkpA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t79 ALDO-KETO REDUCTASE,
OXIDOREDUCTASE

(Salmonella
enterica) 		PF00248
(Aldo_ket_red) 		5 ASP A   6
ASP A 306
GLN A 275
LYS A 276
GLY A 309
 None
NDP  A 404 (-3.5A)
None
NDP  A 404 ( 4.3A)
None
 1.29A 5hfjH-5t79A:
undetectable		 5hfjH-5t79A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tey N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT

(Homo sapiens) 		PF05063
(MT-A70) 		5 ASP A 377
ASP A 395
PRO A 397
LYS A 513
GLY A 535
 SAH  A 601 (-3.2A)
SAH  A 601 (-3.8A)
SAH  A 601 (-4.3A)
SAH  A 601 (-4.9A)
SAH  A 601 ( 4.6A)
 0.91A 5hfjH-5teyA:
14.0		 5hfjH-5teyA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tey N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT

(Homo sapiens) 		PF05063
(MT-A70) 		5 ASP A 377
ASP A 395
PRO A 397
LYS A 513
PHE A 534
 SAH  A 601 (-3.2A)
SAH  A 601 (-3.8A)
SAH  A 601 (-4.3A)
SAH  A 601 (-4.9A)
SAH  A 601 (-4.7A)
 0.59A 5hfjH-5teyA:
14.0		 5hfjH-5teyA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w0x TIP41-LIKE PROTEIN

(Mus musculus) 		no annotation 5 ALA A  72
PRO A  46
PHE A 156
GLY A  51
THR A  25
 None
 1.31A 5hfjH-5w0xA:
undetectable		 5hfjH-5w0xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x41 COBALT ABC
TRANSPORTER
ATP-BINDING PROTEIN

(Rhodobacter
capsulatus) 		PF00005
(ABC_tran) 		5 ASP A 208
ALA A 224
ASP A 199
THR A 168
SER A  33
 None
 1.19A 5hfjH-5x41A:
undetectable		 5hfjH-5x41A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xom GLYCOSAMINOGLYCAN
XYLOSYLKINASE

(Hydra vulgaris) 		no annotation 5 ALA A 156
ASP A 299
GLY A 150
THR A 146
TYR A 151
 None
 1.35A 5hfjH-5xomA:
undetectable		 5hfjH-5xomA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z2g L-AMINO ACID OXIDASE

(Naja atra) 		no annotation 5 ASP A 243
ALA A 244
GLY A 480
THR A 485
SER A 242
 None
None
FAD  A 604 (-4.0A)
FAD  A 604 (-3.5A)
None
 1.22A 5hfjH-5z2gA:
undetectable		 5hfjH-5z2gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6brr DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A

(Homo sapiens) 		no annotation 5 ASP A 686
PRO A 709
PHE A 640
GLY A 642
THR A 645
 SAH  A1001 (-3.0A)
SAH  A1001 (-3.7A)
SAH  A1001 (-4.4A)
SAH  A1001 (-3.4A)
SAH  A1001 (-3.5A)
 0.55A 5hfjH-6brrA:
2.1		 5hfjH-6brrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dw1 -

(-) 		no annotation 5 ALA C 181
THR C 129
GLN C  67
PHE C  45
THR C  42
 None
ABU  C 405 (-2.7A)
None
None
None
 1.23A 5hfjH-6dw1C:
undetectable		 5hfjH-6dw1C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fik POLYKETIDE SYNTHASE

(Cercospora
nicotianae) 		no annotation 5 ALA A 288
GLN A  92
GLY A 117
THR A 124
SER A 284
 None
 1.41A 5hfjH-6fikA:
undetectable		 5hfjH-6fikA:
undetectable