SIMILAR PATTERNS OF AMINO ACIDS FOR 5HFJ_G_SAMG301_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1boo PROTEIN (N-4
CYTOSINE-SPECIFIC
METHYLTRANSFERASE
PVU II)

(Proteus
vulgaris) 		PF01555
(N6_N4_Mtase) 		4 ASP A  34
HIS A 246
SER A 276
GLU A 294
 SAH  A 401 (-4.0A)
SAH  A 401 (-4.0A)
SAH  A 401 (-2.7A)
SAH  A 401 (-2.9A)
 0.53A 5hfjG-1booA:
20.0		 5hfjG-1booA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f4h BETA-GALACTOSIDASE

(Escherichia
coli) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		4 ASP A 997
HIS A 391
SER A 390
GLU A 537
 None
 1.33A 5hfjG-1f4hA:
1.0		 5hfjG-1f4hA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wln AFADIN

(Mus musculus) 		PF00498
(FHA) 		4 ASP A  26
HIS A 107
SER A 106
GLU A  16
 None
 1.37A 5hfjG-1wlnA:
0.0		 5hfjG-1wlnA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN

(Geobacillus
kaustophilus) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		4 ASP A1103
HIS A1186
SER A1182
GLU A1157
 None
DGT  A1456 (-4.1A)
None
None
 1.47A 5hfjG-3f2bA:
0.0		 5hfjG-3f2bA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sfv LIDA PROTEIN,
SUBSTRATE OF THE
DOT/ICM SYSTEM

(Legionella
pneumophila) 		no annotation 4 ASP B 336
HIS B 317
SER B 261
GLU B 259
 None
 1.49A 5hfjG-3sfvB:
0.0		 5hfjG-3sfvB:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tkl LIDA PROTEIN,
SUBSTRATE OF THE
DOT/ICM SYSTEM

(Legionella
pneumophila) 		no annotation 4 ASP B 336
HIS B 317
SER B 261
GLU B 259
 None
 1.50A 5hfjG-3tklB:
0.0		 5hfjG-3tklB:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tm5 CRYSTAL STRUCTURE OF
TRM14

(Pyrococcus
furiosus) 		PF01170
(UPF0020)
PF02926
(THUMP) 		4 ASP A 276
HIS A 198
SER A 228
GLU A 248
 SFG  A 401 (-3.4A)
SFG  A 401 (-3.8A)
SFG  A 401 (-3.6A)
SFG  A 401 (-2.6A)
 0.64A 5hfjG-3tm5A:
3.4		 5hfjG-3tm5A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tnf LIDA

(Legionella
pneumophila) 		no annotation 4 ASP B 336
HIS B 317
SER B 261
GLU B 259
 None
 1.44A 5hfjG-3tnfB:
0.0		 5hfjG-3tnfB:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4blu RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J

(Escherichia
coli) 		PF04378
(RsmJ) 		4 ASP A  40
HIS A 120
SER A 122
GLU A 118
 None
 1.38A 5hfjG-4bluA:
2.4		 5hfjG-4bluA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z26 PUTATIVE GMC-TYPE
OXIDOREDUCTASE R135

(Acanthamoeba
polyphaga
mimivirus) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 ASP A 523
HIS A 350
SER A 514
GLU A 516
 None
 1.46A 5hfjG-4z26A:
undetectable		 5hfjG-4z26A:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bm8 ENVELOPE
GLYCOPROTEIN B

(Human
alphaherpesvirus
1) 		no annotation 4 ASP A 389
HIS A 433
SER A 457
GLU A 144
 None
 1.21A 5hfjG-6bm8A:
undetectable		 5hfjG-6bm8A:
undetectable