SIMILAR PATTERNS OF AMINO ACIDS FOR 5HFJ_E_SAME301_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1a3x | PYRUVATE KINASE (Saccharomycescerevisiae) |
PF00224(PK)PF02887(PK_C) | 5 | ALA A 297SER A 303THR A 311GLU A 334SER A 332 | None | 1.26A | 5hfjE-1a3xA:undetectable | 5hfjE-1a3xA:19.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1aow | ANNEXIN IV (Bos taurus) |
PF00191(Annexin) | 5 | ASP A 218GLY A 181THR A 187GLU A 226SER A 222 | None | 1.12A | 5hfjE-1aowA:undetectable | 5hfjE-1aowA:20.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1boo | PROTEIN (N-4CYTOSINE-SPECIFICMETHYLTRANSFERASEPVU II) (Proteusvulgaris) |
PF01555(N6_N4_Mtase) | 7 | ASP A 34PHE A 273GLY A 275SER A 276THR A 278GLU A 294TYR A 299 | SAH A 401 (-4.0A)SAH A 401 (-4.6A)SAH A 401 (-3.5A)SAH A 401 (-2.7A)SAH A 401 (-4.0A)SAH A 401 (-2.9A)SAH A 401 (-4.2A) | 0.45A | 5hfjE-1booA:20.0 | 5hfjE-1booA:22.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g60 | ADENINE-SPECIFICMETHYLTRANSFERASEMBOIIA (Moraxella bovis) |
PF01555(N6_N4_Mtase) | 7 | ASP A 30LYS A 197PHE A 220GLY A 222SER A 223THR A 225TYR A 246 | SAM A 500 (-3.7A)NoneSAM A 500 (-4.6A)SAM A 500 (-3.2A)SAM A 500 (-2.8A)SAM A 500 (-3.4A)SAM A 500 (-4.4A) | 0.69A | 5hfjE-1g60A:23.4 | 5hfjE-1g60A:29.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gpe | PROTEIN (GLUCOSEOXIDASE) (Penicilliumamagasakiense) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 5 | ALA A 292PRO A 447GLY A 255SER A 298TYR A 304 | None | 1.25A | 5hfjE-1gpeA:undetectable | 5hfjE-1gpeA:18.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ixk | METHYLTRANSFERASE (Pyrococcushorikoshii) |
PF01189(Methyltr_RsmB-F)PF17125(Methyltr_RsmF_N) | 5 | ALA A 278PHE A 308GLY A 306SER A 305THR A 202 | None | 1.30A | 5hfjE-1ixkA:3.5 | 5hfjE-1ixkA:24.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j9l | STATIONARY PHASESURVIVAL PROTEIN (Thermotogamaritima) |
PF01975(SurE) | 5 | ASP A 135ASP A 9GLY A 93SER A 92THR A 6 | None CA A1301 (-2.3A)NoneNoneNone | 1.23A | 5hfjE-1j9lA:undetectable | 5hfjE-1j9lA:20.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kc8 | RIBOSOMAL PROTEINL18E (Haloarculamarismortui) |
PF00828(Ribosomal_L27A) | 5 | ASP P 90ALA P 95PHE P 81GLY P 66SER P 67 | NoneNoneNone A A 660 ( 3.7A) A A 660 ( 3.2A) | 1.27A | 5hfjE-1kc8P:undetectable | 5hfjE-1kc8P:19.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kcx | DIHYDROPYRIMIDINASERELATED PROTEIN-1 (Mus musculus) |
PF01979(Amidohydro_1) | 5 | ALA A 98ASP A 408LYS A 398GLY A 69SER A 385 | None | 1.31A | 5hfjE-1kcxA:undetectable | 5hfjE-1kcxA:16.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1llu | ALCOHOLDEHYDROGENASE (Pseudomonasaeruginosa) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | ALA A 192ASP A 303PRO A 141PHE A 304GLY A 306 | None | 1.25A | 5hfjE-1lluA:2.3 | 5hfjE-1lluA:20.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nt2 | FIBRILLARIN-LIKEPRE-RRNA PROCESSINGPROTEIN (Archaeoglobusfulgidus) |
PF01269(Fibrillarin) | 6 | ASP A 113ALA A 114ASP A 133SER A 68THR A 70GLU A 88 | SAM A 301 (-3.6A)SAM A 301 (-3.4A)SAM A 301 (-3.7A)SAM A 301 ( 3.8A)SAM A 301 (-3.1A)SAM A 301 (-2.4A) | 1.11A | 5hfjE-1nt2A:3.9 | 5hfjE-1nt2A:20.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nw5 | MODIFICATIONMETHYLASE RSRI (Rhodobactersphaeroides) |
PF01555(N6_N4_Mtase) | 6 | ASP A 46ASP A 65LYS A 227PHE A 250GLY A 252SER A 253 | SAM A 401 (-3.6A)SAM A 401 (-3.3A)SAM A 401 (-4.4A)SAM A 401 (-4.7A)SAM A 401 (-3.3A)SAM A 401 (-2.8A) | 0.65A | 5hfjE-1nw5A:20.8 | 5hfjE-1nw5A:24.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o54 | SAM-DEPENDENTO-METHYLTRANSFERASE (Thermotogamaritima) |
PF08704(GCD14) | 5 | ASP A 160ASP A 176GLY A 110SER A 111GLU A 132 | NoneNoneNone CL A 266 ( 4.4A)None | 1.11A | 5hfjE-1o54A:4.2 | 5hfjE-1o54A:22.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1p49 | STERYL-SULFATASE (Homo sapiens) |
PF00884(Sulfatase)PF14707(Sulfatase_C) | 5 | ASP A 310ASP A 35LYS A 134SER A 295TYR A 257 | None CA A 605 (-3.1A)ALS A 75 ( 2.8A)NoneNone | 1.31A | 5hfjE-1p49A:undetectable | 5hfjE-1p49A:16.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rp0 | THIAZOLEBIOSYNTHETIC ENZYME (Arabidopsisthaliana) |
PF01946(Thi4) | 5 | ALA A 161PHE A 193GLY A 46GLU A 70SER A 72 | NoneAHZ A 600 (-4.7A)AHZ A 600 (-3.1A)AHZ A 600 (-2.7A)None | 1.32A | 5hfjE-1rp0A:undetectable | 5hfjE-1rp0A:22.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u1h | 5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINEMETHYLTRANSFERASE (Arabidopsisthaliana) |
PF01717(Meth_synt_2)PF08267(Meth_synt_1) | 5 | ASP A 373ALA A 363ASP A 302PHE A 303SER A 308 | None | 0.97A | 5hfjE-1u1hA:undetectable | 5hfjE-1u1hA:15.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uhg | OVALBUMIN (Gallus gallus) |
PF00079(Serpin) | 5 | ALA A 39ASP A 60PHE A 59GLY A 66GLU A 70 | None | 1.32A | 5hfjE-1uhgA:undetectable | 5hfjE-1uhgA:20.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vrm | HYPOTHETICAL PROTEINTM1553 (Thermotogamaritima) |
PF02424(ApbE) | 5 | ASP A 50ALA A 52GLY A 220THR A 259GLU A 217 | None | 1.25A | 5hfjE-1vrmA:undetectable | 5hfjE-1vrmA:22.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1x1n | 4-ALPHA-GLUCANOTRANSFERASE (Solanumtuberosum) |
PF02446(Glyco_hydro_77) | 5 | ASP A 88ALA A 89PRO A 268SER A 250TYR A 248 | None | 1.03A | 5hfjE-1x1nA:undetectable | 5hfjE-1x1nA:16.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2akz | GAMMA ENOLASE (Homo sapiens) |
PF00113(Enolase_C)PF03952(Enolase_N) | 5 | ALA A 222ASP A 244PHE A 167GLY A 155SER A 156 | None MG A 440 (-2.5A)NoneNoneNone | 1.29A | 5hfjE-2akzA:undetectable | 5hfjE-2akzA:19.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b25 | HYPOTHETICAL PROTEIN (Homo sapiens) |
PF08704(GCD14) | 5 | ASP A 173ASP A 192GLY A 113SER A 114GLU A 135 | SAM A 601 (-3.4A)SAM A 601 (-3.5A)SAM A 601 (-3.2A)SAM A 601 (-4.8A)SAM A 601 (-2.9A) | 1.11A | 5hfjE-2b25A:3.4 | 5hfjE-2b25A:21.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d3i | OVOTRANSFERRIN (Gallus gallus) |
PF00405(Transferrin) | 5 | ALA A 217ASP A 292GLY A 193SER A 189TYR A 188 | None | 1.28A | 5hfjE-2d3iA:undetectable | 5hfjE-2d3iA:17.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e28 | PYRUVATE KINASE (Geobacillusstearothermophilus) |
PF00224(PK)PF00391(PEP-utilizers)PF02887(PK_C) | 5 | ALA A 278SER A 284THR A 292GLU A 315SER A 313 | None | 1.22A | 5hfjE-2e28A:undetectable | 5hfjE-2e28A:18.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2esr | METHYLTRANSFERASE (Streptococcuspyogenes) |
PF03602(Cons_hypoth95) | 6 | ALA A 100ASP A 117PHE A 49GLY A 51SER A 52GLU A 71 | None | 0.74A | 5hfjE-2esrA:3.6 | 5hfjE-2esrA:20.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fhp | METHYLASE, PUTATIVE (Enterococcusfaecalis) |
PF03602(Cons_hypoth95) | 5 | ASP A 99ALA A 100ASP A 120GLY A 51SER A 52 | None | 0.77A | 5hfjE-2fhpA:6.5 | 5hfjE-2fhpA:23.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fpo | METHYLASE YHHF (Escherichiacoli) |
PF03602(Cons_hypoth95) | 6 | ALA A 110ASP A 127PHE A 60GLY A 62SER A 63GLU A 82 | CL A 401 (-3.8A)NoneNoneNoneNoneNone | 0.78A | 5hfjE-2fpoA:3.8 | 5hfjE-2fpoA:22.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ift | PUTATIVE METHYLASEHI0767 (Haemophilusinfluenzae) |
PF03602(Cons_hypoth95) | 5 | ASP A 132PHE A 61GLY A 63SER A 64GLU A 83 | None | 1.26A | 5hfjE-2iftA:5.3 | 5hfjE-2iftA:21.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ipx | RRNA2'-O-METHYLTRANSFERASE FIBRILLARIN (Homo sapiens) |
PF01269(Fibrillarin) | 5 | ASP A 217ALA A 218ASP A 237THR A 173GLU A 192 | MTA A4001 (-3.4A)MTA A4001 (-3.4A)MTA A4001 (-4.3A)NoneMTA A4001 (-2.7A) | 1.18A | 5hfjE-2ipxA:3.7 | 5hfjE-2ipxA:21.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ker | ALPHA-AMYLASEINHIBITOR Z-2685 (Streptomycesparvulus) |
PF01356(A_amylase_inhib) | 5 | ALA A 41ASP A 20PHE A 54GLY A 56TYR A 63 | None | 0.94A | 5hfjE-2kerA:undetectable | 5hfjE-2kerA:17.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2mzw | ELONGATION FACTOR G (Staphylococcusaureus) |
PF00679(EFG_C)PF03764(EFG_IV)PF14492(EFG_II) | 5 | ASP A 561ALA A 555ASP A 442SER A 481TYR A 482 | None | 1.24A | 5hfjE-2mzwA:undetectable | 5hfjE-2mzwA:21.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r1z | BRCA1-ASSOCIATEDRING DOMAIN PROTEIN1 (Homo sapiens) |
PF00533(BRCT)PF16589(BRCT_2) | 5 | PRO A 610GLY A 576SER A 575THR A 617SER A 579 | None | 1.02A | 5hfjE-2r1zA:undetectable | 5hfjE-2r1zA:20.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vgi | PYRUVATE KINASEISOZYMES R/L (Homo sapiens) |
PF00224(PK)PF02887(PK_C) | 5 | ALA A 370SER A 376THR A 384GLU A 407SER A 405 | PGA A1575 ( 4.9A)NoneNoneNonePGA A1575 ( 4.9A) | 1.20A | 5hfjE-2vgiA:undetectable | 5hfjE-2vgiA:17.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wjs | LAMININ SUBUNITALPHA-2 (Mus musculus) |
PF00054(Laminin_G_1) | 5 | ASP A2288ALA A2287ASP A2268GLY A2207THR A2265 | NoneNone CA A5001 (-3.2A) CA A5001 ( 4.3A)None | 1.31A | 5hfjE-2wjsA:undetectable | 5hfjE-2wjsA:17.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xqx | ENDO-BETA-N-ACETYLGLUCOSAMINIDASE D (Streptococcuspneumoniae) |
PF00754(F5_F8_type_C) | 5 | ASP A 930ALA A 937GLY A 847SER A 848SER A 929 | None | 1.27A | 5hfjE-2xqxA:undetectable | 5hfjE-2xqxA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yxl | 450AA LONGHYPOTHETICAL FMUPROTEIN (Pyrococcushorikoshii) |
PF01189(Methyltr_RsmB-F)PF17125(Methyltr_RsmF_N) | 5 | ALA A 322ASP A 291PRO A 339PHE A 290SER A 374 | NoneSFG A5748 (-2.9A)SFG A5748 (-4.0A)NoneNone | 1.08A | 5hfjE-2yxlA:2.9 | 5hfjE-2yxlA:20.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zie | PUTATIVEMODIFICATIONMETHYLASE (Thermusthermophilus) |
PF01555(N6_N4_Mtase) | 6 | ASP A 28ALA A 29LYS A 219PHE A 243GLY A 245GLU A 264 | None | 1.46A | 5hfjE-2zieA:20.4 | 5hfjE-2zieA:26.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zie | PUTATIVEMODIFICATIONMETHYLASE (Thermusthermophilus) |
PF01555(N6_N4_Mtase) | 7 | ASP A 28ALA A 29PHE A 243GLY A 245THR A 248GLU A 264TYR A 269 | None | 0.67A | 5hfjE-2zieA:20.4 | 5hfjE-2zieA:26.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b9t | TWIN-ARGININETRANSLOCATIONPATHWAY SIGNALPROTEIN (Methylobacillusflagellatus) |
PF03069(FmdA_AmdA) | 5 | ASP A 230ALA A 231GLY A 200SER A 201TYR A 227 | None | 1.27A | 5hfjE-3b9tA:undetectable | 5hfjE-3b9tA:19.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e05 | PRECORRIN-6YC5,15-METHYLTRANSFERASE(DECARBOXYLATING) (Geobactermetallireducens) |
no annotation | 5 | ALA A 307GLY A 258SER A 259GLU A 279TYR A 284 | None CL A 1 ( 4.7A) CL A 1 (-4.5A)NoneNone | 0.89A | 5hfjE-3e05A:3.8 | 5hfjE-3e05A:22.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eoe | PYRUVATE KINASE (Toxoplasmagondii) |
PF00224(PK)PF02887(PK_C) | 5 | ALA A 312SER A 318THR A 326GLU A 349SER A 347 | None | 1.22A | 5hfjE-3eoeA:undetectable | 5hfjE-3eoeA:17.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gu3 | METHYLTRANSFERASE (Bacillus cereus) |
PF13847(Methyltransf_31) | 5 | ASP A 97ALA A 98PHE A 115GLY A 49SER A 72 | SAH A 401 (-3.3A)SAH A 401 (-3.3A)SAH A 401 (-4.8A)SAH A 401 (-3.3A)SAH A 401 (-3.6A) | 0.84A | 5hfjE-3gu3A:4.1 | 5hfjE-3gu3A:20.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gyx | ADENYLYLSULFATEREDUCTASE (Desulfovibriogigas) |
PF00890(FAD_binding_2) | 5 | ALA A 626PRO A 412GLY A 553THR A 548TYR A 559 | None | 1.20A | 5hfjE-3gyxA:undetectable | 5hfjE-3gyxA:15.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3khk | TYPE IRESTRICTION-MODIFICATION SYSTEMMETHYLATION SUBUNIT (Methanosarcinamazei) |
PF02384(N6_Mtase)PF12161(HsdM_N) | 5 | ASP A 317GLY A 253SER A 254GLU A 289SER A 290 | None | 0.55A | 5hfjE-3khkA:2.8 | 5hfjE-3khkA:20.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l7i | TEICHOIC ACIDBIOSYNTHESIS PROTEINF (Staphylococcusepidermidis) |
PF04464(Glyphos_transf) | 5 | ASP A 661ASP A 629PHE A 628GLY A 631TYR A 695 | None | 1.19A | 5hfjE-3l7iA:undetectable | 5hfjE-3l7iA:16.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ldu | PUTATIVE METHYLASE (Clostridioidesdifficile) |
PF01170(UPF0020)PF02926(THUMP) | 5 | ASP A 289ALA A 290GLY A 202SER A 203THR A 205 | GTP A 383 ( 3.8A)GTP A 383 (-3.7A)GTP A 383 (-2.6A)GTP A 383 (-2.7A)GTP A 383 (-3.5A) | 0.45A | 5hfjE-3lduA:2.0 | 5hfjE-3lduA:23.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mkq | COATOMERBETA'-SUBUNITCOATOMER SUBUNITALPHA (Saccharomycescerevisiae;Saccharomycescerevisiae) |
PF00400(WD40)PF04053(Coatomer_WDAD)PF04053(Coatomer_WDAD) | 5 | ALA A 769LYS B 719PHE A 770GLY B 715SER A 773 | None | 1.11A | 5hfjE-3mkqA:undetectable | 5hfjE-3mkqA:15.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ois | CYSTEINE PROTEASE (Xylellafastidiosa) |
PF00112(Peptidase_C1) | 5 | ALA A 82ASP A 71GLY A 32SER A 31TYR A 33 | None | 1.27A | 5hfjE-3oisA:undetectable | 5hfjE-3oisA:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p9n | POSSIBLEMETHYLTRANSFERASE(METHYLASE) (Mycobacteriumtuberculosis) |
PF03602(Cons_hypoth95) | 6 | ASP A 119PRO A 17GLY A 53SER A 54GLU A 73SER A 74 | None | 1.18A | 5hfjE-3p9nA:3.3 | 5hfjE-3p9nA:18.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pp7 | PYRUVATE KINASE (Leishmaniamexicana) |
PF00224(PK)PF02887(PK_C) | 5 | ALA A 295SER A 301THR A 309GLU A 332SER A 330 | None | 1.23A | 5hfjE-3pp7A:undetectable | 5hfjE-3pp7A:19.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qv9 | PYRUVATE KINASE 2 (Trypanosomacruzi) |
PF00224(PK)PF02887(PK_C) | 5 | ALA A 296SER A 302THR A 310GLU A 333SER A 331 | NoneNoneNoneNonePO4 A 501 (-4.3A) | 1.23A | 5hfjE-3qv9A:2.0 | 5hfjE-3qv9A:18.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qxb | PUTATIVE XYLOSEISOMERASE (Rhodospirillumrubrum) |
PF01261(AP_endonuc_2) | 5 | ASP A 139ALA A 135ASP A 123SER A 118THR A 165 | None | 1.04A | 5hfjE-3qxbA:undetectable | 5hfjE-3qxbA:19.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sgz | HYDROXYACID OXIDASE2 (Rattusnorvegicus) |
PF01070(FMN_dh) | 5 | ASP A 7ALA A 6LYS A 289GLY A 284GLU A 326 | None | 1.27A | 5hfjE-3sgzA:undetectable | 5hfjE-3sgzA:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t05 | PYRUVATE KINASE (Staphylococcusaureus) |
PF00224(PK)PF00391(PEP-utilizers)PF02887(PK_C) | 5 | ALA A 276SER A 282THR A 290GLU A 313SER A 311 | None | 1.20A | 5hfjE-3t05A:undetectable | 5hfjE-3t05A:17.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tm5 | CRYSTAL STRUCTURE OFTRM14 (Pyrococcusfuriosus) |
PF01170(UPF0020)PF02926(THUMP) | 6 | ASP A 276ALA A 277GLY A 227SER A 228THR A 230GLU A 248 | SFG A 401 (-3.4A)SFG A 401 (-3.1A)SFG A 401 ( 3.7A)SFG A 401 (-3.6A)SFG A 401 (-3.3A)SFG A 401 (-2.6A) | 0.57A | 5hfjE-3tm5A:5.8 | 5hfjE-3tm5A:23.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tma | METHYLTRANSFERASE (Thermusthermophilus) |
PF01170(UPF0020)PF02926(THUMP) | 5 | ASP A 243ALA A 244PHE A 192GLY A 194SER A 195 | None | 0.68A | 5hfjE-3tmaA:3.5 | 5hfjE-3tmaA:17.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tma | METHYLTRANSFERASE (Thermusthermophilus) |
PF01170(UPF0020)PF02926(THUMP) | 5 | ASP A 243ALA A 244PHE A 192GLY A 194THR A 197 | None | 0.72A | 5hfjE-3tmaA:3.5 | 5hfjE-3tmaA:17.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v8v | RIBOSOMAL RNA LARGESUBUNITMETHYLTRANSFERASE L (Escherichiacoli) |
PF01170(UPF0020)PF02926(THUMP)PF10672(Methyltrans_SAM) | 5 | ASP A 290GLY A 199SER A 200THR A 202SER A 263 | SAM A 801 (-3.0A)SAM A 801 (-3.2A)SAM A 801 (-3.0A)SAM A 801 (-4.1A)SAM A 801 (-3.5A) | 0.61A | 5hfjE-3v8vA:3.5 | 5hfjE-3v8vA:14.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vyw | MNMC2 (Aquifexaeolicus) |
PF05430(Methyltransf_30) | 5 | ASP A 174ALA A 175ASP A 193GLY A 106GLU A 133 | SAM A 501 (-3.4A)SAM A 501 (-3.8A)SAM A 501 (-3.8A)SAM A 501 (-3.3A)SAM A 501 (-2.3A) | 0.76A | 5hfjE-3vywA:5.3 | 5hfjE-3vywA:22.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wvo | CRISPR-ASSOCIATEDPROTEIN, CSE1 FAMILY (Thermobifidafusca) |
PF09481(CRISPR_Cse1) | 5 | ASP A 374ALA A 475GLY A 414SER A 413GLU A 410 | None | 1.24A | 5hfjE-3wvoA:undetectable | 5hfjE-3wvoA:17.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zsc | PECTATETRISACCHARIDE-LYASE (Thermotogamaritima) |
PF00544(Pec_lyase_C) | 5 | ASP A 139LYS A 163PHE A 116GLY A 137TYR A 104 | AQA A1338 (-3.9A)AQA A1338 (-3.0A)NoneNoneNone | 1.03A | 5hfjE-3zscA:undetectable | 5hfjE-3zscA:19.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b4d | FERREDOXIN-NADPREDUCTASE (Xanthomonascitri) |
PF00175(NAD_binding_1)PF00970(FAD_binding_6) | 6 | ASP A 211ALA A 213GLY A 248SER A 241THR A 246TYR A 250 | None | 1.24A | 5hfjE-4b4dA:2.8 | 5hfjE-4b4dA:22.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cns | DIHYDROPYRIMIDINASE-LIKE 3 (Homo sapiens) |
PF01979(Amidohydro_1) | 5 | ALA A 98ASP A 408LYS A 398GLY A 69SER A 385 | None | 1.32A | 5hfjE-4cnsA:undetectable | 5hfjE-4cnsA:18.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4df3 | FIBRILLARIN-LIKERRNA/TRNA2'-O-METHYLTRANSFERASE (Aeropyrumpernix) |
PF01269(Fibrillarin) | 5 | ALA A 135ASP A 154SER A 88THR A 90GLU A 109 | SAM A 301 (-3.5A)SAM A 301 (-3.6A)NoneSAM A 301 (-3.9A)SAM A 301 (-2.9A) | 1.30A | 5hfjE-4df3A:4.0 | 5hfjE-4df3A:21.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4df3 | FIBRILLARIN-LIKERRNA/TRNA2'-O-METHYLTRANSFERASE (Aeropyrumpernix) |
PF01269(Fibrillarin) | 5 | ASP A 134ALA A 135SER A 88THR A 90GLU A 109 | SAM A 301 (-3.3A)SAM A 301 (-3.5A)NoneSAM A 301 (-3.9A)SAM A 301 (-2.9A) | 0.79A | 5hfjE-4df3A:4.0 | 5hfjE-4df3A:21.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4drs | PYRUVATE KINASE (Cryptosporidiumparvum) |
PF00224(PK)PF02887(PK_C) | 5 | ALA A 327SER A 333THR A 341GLU A 364SER A 362 | NoneNoneNoneNoneGOL A 603 ( 3.4A) | 1.19A | 5hfjE-4drsA:undetectable | 5hfjE-4drsA:17.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ewp | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 3 (Micrococcusluteus) |
PF08541(ACP_syn_III_C)PF08545(ACP_syn_III) | 5 | ALA A 102PRO A 313GLY A 149THR A 307TYR A 126 | None | 1.20A | 5hfjE-4ewpA:undetectable | 5hfjE-4ewpA:18.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fix | UDP-GALACTOFURANOSYLTRANSFERASE GLFT2 (Mycobacteriumtuberculosis) |
PF13641(Glyco_tranf_2_3) | 5 | ASP A 199LYS A 369PHE A 169GLY A 232TYR A 236 | None | 1.29A | 5hfjE-4fixA:undetectable | 5hfjE-4fixA:15.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fix | UDP-GALACTOFURANOSYLTRANSFERASE GLFT2 (Mycobacteriumtuberculosis) |
PF13641(Glyco_tranf_2_3) | 5 | LYS A 369PHE A 169GLY A 232SER A 233TYR A 236 | None | 1.30A | 5hfjE-4fixA:undetectable | 5hfjE-4fixA:15.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gw9 | BACTERIOPHYTOCHROME (Rhodopseudomonaspalustris) |
PF00360(PHY)PF00989(PAS)PF01590(GAF)PF08446(PAS_2) | 5 | ALA A 422ASP A 406GLY A 419SER A 418THR A 414 | None | 1.19A | 5hfjE-4gw9A:undetectable | 5hfjE-4gw9A:14.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gz7 | DIHYDROPYRIMIDINASE (Tetraodonnigroviridis) |
PF01979(Amidohydro_1) | 5 | ALA A 88ASP A 398LYS A 388GLY A 59SER A 375 | None | 1.27A | 5hfjE-4gz7A:undetectable | 5hfjE-4gz7A:17.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hyv | PYRUVATE KINASE 1 (Trypanosomabrucei) |
PF00224(PK)PF02887(PK_C) | 5 | ALA A 296SER A 302THR A 310GLU A 333SER A 331 | PEP A1003 ( 3.9A)NoneNoneNonePEP A1003 ( 4.9A) | 1.20A | 5hfjE-4hyvA:undetectable | 5hfjE-4hyvA:19.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j1s | POLYKETIDE SYNTHASEPKSJ (Bacillussubtilis) |
PF08659(KR) | 5 | ALA A 61ASP A 338PHE A 336GLY A 104SER A 106 | None | 1.32A | 5hfjE-4j1sA:2.4 | 5hfjE-4j1sA:19.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l1g | PEPTIDOGLYCANN-ACETYLGLUCOSAMINEDEACETYLASE (Bacillus cereus) |
PF01522(Polysacc_deac_1) | 5 | ASP A 84PRO A 165LYS A 264PHE A 104GLY A 129 | None | 1.31A | 5hfjE-4l1gA:undetectable | 5hfjE-4l1gA:23.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p4o | DNA POLYMERASE BETA (Leishmaniainfantum) |
PF10391(DNA_pol_lambd_f)PF14716(HHH_8)PF14791(DNA_pol_B_thumb)PF14792(DNA_pol_B_palm) | 5 | ALA A 283ASP A 271PHE A 287GLY A 183SER A 184 | NoneNoneNoneD3T A 401 (-3.2A)D3T A 401 (-2.5A) | 1.10A | 5hfjE-4p4oA:undetectable | 5hfjE-4p4oA:19.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q0c | VIRULENCE SENSORPROTEIN BVGS (Bordetellapertussis) |
PF00497(SBP_bac_3) | 5 | PRO A 319SER A 465THR A 462SER A 528TYR A 468 | None | 1.13A | 5hfjE-4q0cA:undetectable | 5hfjE-4q0cA:16.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rv3 | 1-PHOSPHATIDYLINOSITOL PHOSPHODIESTERASE (Staphylococcusaureus) |
PF00388(PI-PLC-X) | 5 | ALA A 96ASP A 65GLY A 33SER A 34THR A 48 | None | 1.06A | 5hfjE-4rv3A:undetectable | 5hfjE-4rv3A:21.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u7t | DNA(CYTOSINE-5)-METHYLTRANSFERASE 3A (Homo sapiens) |
PF00145(DNA_methylase) | 5 | ASP A 686PHE A 640GLY A 642THR A 645GLU A 664 | SAH A1004 (-3.0A)SAH A1004 (-4.6A)SAH A1004 (-3.3A)SAH A1004 (-3.3A)SAH A1004 (-3.0A) | 0.71A | 5hfjE-4u7tA:undetectable | 5hfjE-4u7tA:18.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xqk | LLABIII (Lactococcuslactis) |
PF00271(Helicase_C)PF02384(N6_Mtase)PF04851(ResIII)PF13156(Mrr_cat_2) | 5 | ASP A 981PHE A 904GLY A 906THR A 909GLU A 944 | None | 0.72A | 5hfjE-4xqkA:2.9 | 5hfjE-4xqkA:9.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xuo | ENDO-1,4-BETA-XYLANASE C (Paenibacillusbarcinonensis) |
PF02018(CBM_4_9) | 5 | ASP A 141ALA A 144SER A 59THR A 25TYR A 136 | None | 1.20A | 5hfjE-4xuoA:undetectable | 5hfjE-4xuoA:19.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xup | ENDO-1,4-BETA-XYLANASE C (Paenibacillusbarcinonensis) |
PF02018(CBM_4_9) | 5 | ASP A 141ALA A 144SER A 59THR A 25TYR A 136 | None | 1.22A | 5hfjE-4xupA:undetectable | 5hfjE-4xupA:21.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yj5 | PYRUVATE KINASE PKM (Homo sapiens) |
PF00224(PK)PF02887(PK_C) | 5 | ALA A 327SER A 333THR A 341GLU A 364SER A 362 | PYR A 601 ( 4.5A)NoneNoneNoneNone | 1.24A | 5hfjE-4yj5A:undetectable | 5hfjE-4yj5A:17.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yvd | PLEIOTROPICREGULATOR 1 (Homo sapiens) |
PF00400(WD40) | 5 | ALA A 431ASP A 393GLY A 390SER A 389SER A 429 | None | 1.30A | 5hfjE-4yvdA:undetectable | 5hfjE-4yvdA:20.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zcf | RESTRICTIONENDONUCLEASEECOP15I,MODIFICATION SUBUNIT (Escherichiacoli) |
PF01555(N6_N4_Mtase) | 7 | ASP A 101ASP A 123LYS A 418PHE A 441GLY A 443SER A 444THR A 446 | None | 0.79A | 5hfjE-4zcfA:18.7 | 5hfjE-4zcfA:17.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bqs | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 3 (Streptococcuspneumoniae) |
PF08541(ACP_syn_III_C)PF08545(ACP_syn_III) | 5 | ALA A 79GLY A 310SER A 309THR A 319SER A 281 | NoneNoneNoneNone4VN A 402 ( 4.9A) | 1.30A | 5hfjE-5bqsA:undetectable | 5hfjE-5bqsA:20.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5csu | 4-ALPHA-GLUCANOTRANSFERASE DPE1,CHLOROPLASTIC/AMYLOPLASTIC (Arabidopsisthaliana) |
PF02446(Glyco_hydro_77) | 5 | ASP A 140ALA A 141PRO A 320SER A 302TYR A 300 | None | 1.10A | 5hfjE-5csuA:undetectable | 5hfjE-5csuA:19.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e72 | N2,N2-DIMETHYLGUANOSINETRNAMETHYLTRANSFERASE (Thermococcuskodakarensis) |
PF01170(UPF0020)PF02926(THUMP) | 5 | ASP A 235ALA A 236ASP A 254PHE A 187GLY A 189 | SAM A 400 (-3.4A)SAM A 400 (-3.5A)NoneSAM A 400 (-4.7A)SAM A 400 (-3.3A) | 0.59A | 5hfjE-5e72A:5.6 | 5hfjE-5e72A:22.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f9s | SERINE--PYRUVATEAMINOTRANSFERASE (Homo sapiens) |
PF00266(Aminotran_5) | 5 | PRO A 353GLY A 106THR A 127GLU A 157SER A 158 | NoneNoneNoneNonePLP A 401 (-1.8A) | 1.13A | 5hfjE-5f9sA:undetectable | 5hfjE-5f9sA:19.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ffj | ENDONUCLEASE ANDMETHYLASE LLAGI (Lactococcuslactis) |
PF00271(Helicase_C)PF02384(N6_Mtase)PF04851(ResIII) | 5 | ASP A 981PHE A 904GLY A 906THR A 909GLU A 944 | None | 0.90A | 5hfjE-5ffjA:2.9 | 5hfjE-5ffjA:10.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gin | FIBRILLARIN-LIKERRNA/TRNA2'-O-METHYLTRANSFERASE (Sulfolobussolfataricus) |
PF01269(Fibrillarin) | 5 | ASP E 133ALA E 134ASP E 153THR E 89GLU E 108 | SAH E 301 (-3.5A)SAH E 301 (-3.6A)SAH E 301 (-3.7A) A I 6 ( 3.5A)SAH E 301 (-3.0A) | 1.31A | 5hfjE-5ginE:3.5 | 5hfjE-5ginE:21.54 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5hfj | ADENINE SPECIFIC DNAMETHYLTRANSFERASE(DPNA) (Helicobacterpylori) |
PF01555(N6_N4_Mtase) | 10 | ASP A 8ALA A 9ASP A 29PHE A 195GLY A 197SER A 198THR A 200GLU A 216SER A 217TYR A 221 | SAM A 301 (-3.4A)SAM A 301 (-3.2A)SAM A 301 (-3.2A)SAM A 301 (-4.6A)SAM A 301 (-3.4A)SAM A 301 (-2.5A)SAM A 301 (-3.6A)SAM A 301 (-3.1A)SAM A 301 (-2.8A)SAM A 301 (-4.2A) | 0.33A | 5hfjE-5hfjA:32.9 | 5hfjE-5hfjA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i5d | INNER MEMBRANEPROTEIN YEJM (Salmonellaenterica) |
PF00884(Sulfatase)PF11893(DUF3413) | 5 | ASP A 303ASP A 490GLY A 312SER A 513THR A 496 | None | 1.31A | 5hfjE-5i5dA:undetectable | 5hfjE-5i5dA:14.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j6b | ALDEHYDEDEHYDROGENASE (Burkholderiathailandensis) |
PF00171(Aldedh) | 5 | ALA A 254GLY A 282SER A 281SER A 438TYR A 279 | None | 1.32A | 5hfjE-5j6bA:undetectable | 5hfjE-5j6bA:17.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jkp | UNCHARACTERIZEDPROTEIN (Pseudomonasaeruginosa) |
PF08238(Sel1) | 5 | ASP A 138ALA A 136ASP A 121PHE A 119GLY A 123 | None | 1.32A | 5hfjE-5jkpA:undetectable | 5hfjE-5jkpA:17.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mqs | BETA-L-ARABINOBIOSIDASE (Bacteroidesthetaiotaomicron) |
PF13088(BNR_2) | 5 | ASP A 491ASP A 453PRO A 437SER A 436TYR A 435 | None CA A1203 (-2.4A)NoneNoneNone | 1.25A | 5hfjE-5mqsA:undetectable | 5hfjE-5mqsA:11.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wrp | PYRUVATE KINASE (Mycobacteriumtuberculosis) |
no annotation | 5 | ALA A 275SER A 281THR A 289GLU A 312SER A 310 | None | 1.24A | 5hfjE-5wrpA:undetectable | 5hfjE-5wrpA:17.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xh9 | EXTRACELLULARINVERTASE (Aspergilluskawachii) |
PF00251(Glyco_hydro_32N)PF08244(Glyco_hydro_32C) | 5 | ALA A 119ASP A 194PHE A 121GLY A 123SER A 124 | None | 1.19A | 5hfjE-5xh9A:undetectable | 5hfjE-5xh9A:17.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xyi | GUANINENUCLEOTIDE-BINDINGPROTEIN BETASUBUNIT, PUTATIVE (Trichomonasvaginalis) |
no annotation | 5 | ASP g 54ALA g 34GLY g 321SER g 320SER g 52 | G 21218 ( 4.9A)NoneNoneNoneNone | 1.27A | 5hfjE-5xyig:undetectable | 5hfjE-5xyig:20.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ya1 | AUTOINDUCER-2 KINASE (Escherichiacoli) |
no annotation | 5 | ASP A 216ALA A 215ASP A 186PRO A 298GLY A 191 | None | 1.28A | 5hfjE-5ya1A:undetectable | 5hfjE-5ya1A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6brr | DNA(CYTOSINE-5)-METHYLTRANSFERASE 3A (Homo sapiens) |
no annotation | 5 | ASP A 686PHE A 640GLY A 642THR A 645GLU A 664 | SAH A1001 (-3.0A)SAH A1001 (-4.4A)SAH A1001 (-3.4A)SAH A1001 (-3.5A)SAH A1001 (-2.7A) | 0.60A | 5hfjE-6brrA:2.5 | 5hfjE-6brrA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6g3u | - (-) |
no annotation | 5 | ASP A 13ASP A 548GLY A 583SER A 562SER A 585 | NoneAKG A 802 (-3.7A)NAP A 801 (-4.1A)NoneNAP A 801 (-3.4A) | 1.09A | 5hfjE-6g3uA:undetectable | 5hfjE-6g3uA:undetectable |