SIMILAR PATTERNS OF AMINO ACIDS FOR 5HFJ_E_SAME301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a3x PYRUVATE KINASE

(Saccharomyces
cerevisiae)
PF00224
(PK)
PF02887
(PK_C)
5 ALA A 297
SER A 303
THR A 311
GLU A 334
SER A 332
None
1.26A 5hfjE-1a3xA:
undetectable
5hfjE-1a3xA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aow ANNEXIN IV

(Bos taurus)
PF00191
(Annexin)
5 ASP A 218
GLY A 181
THR A 187
GLU A 226
SER A 222
None
1.12A 5hfjE-1aowA:
undetectable
5hfjE-1aowA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1boo PROTEIN (N-4
CYTOSINE-SPECIFIC
METHYLTRANSFERASE
PVU II)


(Proteus
vulgaris)
PF01555
(N6_N4_Mtase)
7 ASP A  34
PHE A 273
GLY A 275
SER A 276
THR A 278
GLU A 294
TYR A 299
SAH  A 401 (-4.0A)
SAH  A 401 (-4.6A)
SAH  A 401 (-3.5A)
SAH  A 401 (-2.7A)
SAH  A 401 (-4.0A)
SAH  A 401 (-2.9A)
SAH  A 401 (-4.2A)
0.45A 5hfjE-1booA:
20.0
5hfjE-1booA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g60 ADENINE-SPECIFIC
METHYLTRANSFERASE
MBOIIA


(Moraxella bovis)
PF01555
(N6_N4_Mtase)
7 ASP A  30
LYS A 197
PHE A 220
GLY A 222
SER A 223
THR A 225
TYR A 246
SAM  A 500 (-3.7A)
None
SAM  A 500 (-4.6A)
SAM  A 500 (-3.2A)
SAM  A 500 (-2.8A)
SAM  A 500 (-3.4A)
SAM  A 500 (-4.4A)
0.69A 5hfjE-1g60A:
23.4
5hfjE-1g60A:
29.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpe PROTEIN (GLUCOSE
OXIDASE)


(Penicillium
amagasakiense)
PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C)
5 ALA A 292
PRO A 447
GLY A 255
SER A 298
TYR A 304
None
1.25A 5hfjE-1gpeA:
undetectable
5hfjE-1gpeA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ixk METHYLTRANSFERASE

(Pyrococcus
horikoshii)
PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N)
5 ALA A 278
PHE A 308
GLY A 306
SER A 305
THR A 202
None
1.30A 5hfjE-1ixkA:
3.5
5hfjE-1ixkA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j9l STATIONARY PHASE
SURVIVAL PROTEIN


(Thermotoga
maritima)
PF01975
(SurE)
5 ASP A 135
ASP A   9
GLY A  93
SER A  92
THR A   6
None
CA  A1301 (-2.3A)
None
None
None
1.23A 5hfjE-1j9lA:
undetectable
5hfjE-1j9lA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kc8 RIBOSOMAL PROTEIN
L18E


(Haloarcula
marismortui)
PF00828
(Ribosomal_L27A)
5 ASP P  90
ALA P  95
PHE P  81
GLY P  66
SER P  67
None
None
None
A  A 660 ( 3.7A)
A  A 660 ( 3.2A)
1.27A 5hfjE-1kc8P:
undetectable
5hfjE-1kc8P:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1


(Mus musculus)
PF01979
(Amidohydro_1)
5 ALA A  98
ASP A 408
LYS A 398
GLY A  69
SER A 385
None
1.31A 5hfjE-1kcxA:
undetectable
5hfjE-1kcxA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1llu ALCOHOL
DEHYDROGENASE


(Pseudomonas
aeruginosa)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 ALA A 192
ASP A 303
PRO A 141
PHE A 304
GLY A 306
None
1.25A 5hfjE-1lluA:
2.3
5hfjE-1lluA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nt2 FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN


(Archaeoglobus
fulgidus)
PF01269
(Fibrillarin)
6 ASP A 113
ALA A 114
ASP A 133
SER A  68
THR A  70
GLU A  88
SAM  A 301 (-3.6A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.7A)
SAM  A 301 ( 3.8A)
SAM  A 301 (-3.1A)
SAM  A 301 (-2.4A)
1.11A 5hfjE-1nt2A:
3.9
5hfjE-1nt2A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nw5 MODIFICATION
METHYLASE RSRI


(Rhodobacter
sphaeroides)
PF01555
(N6_N4_Mtase)
6 ASP A  46
ASP A  65
LYS A 227
PHE A 250
GLY A 252
SER A 253
SAM  A 401 (-3.6A)
SAM  A 401 (-3.3A)
SAM  A 401 (-4.4A)
SAM  A 401 (-4.7A)
SAM  A 401 (-3.3A)
SAM  A 401 (-2.8A)
0.65A 5hfjE-1nw5A:
20.8
5hfjE-1nw5A:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o54 SAM-DEPENDENT
O-METHYLTRANSFERASE


(Thermotoga
maritima)
PF08704
(GCD14)
5 ASP A 160
ASP A 176
GLY A 110
SER A 111
GLU A 132
None
None
None
CL  A 266 ( 4.4A)
None
1.11A 5hfjE-1o54A:
4.2
5hfjE-1o54A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p49 STERYL-SULFATASE

(Homo sapiens)
PF00884
(Sulfatase)
PF14707
(Sulfatase_C)
5 ASP A 310
ASP A  35
LYS A 134
SER A 295
TYR A 257
None
CA  A 605 (-3.1A)
ALS  A  75 ( 2.8A)
None
None
1.31A 5hfjE-1p49A:
undetectable
5hfjE-1p49A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rp0 THIAZOLE
BIOSYNTHETIC ENZYME


(Arabidopsis
thaliana)
PF01946
(Thi4)
5 ALA A 161
PHE A 193
GLY A  46
GLU A  70
SER A  72
None
AHZ  A 600 (-4.7A)
AHZ  A 600 (-3.1A)
AHZ  A 600 (-2.7A)
None
1.32A 5hfjE-1rp0A:
undetectable
5hfjE-1rp0A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u1h 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE


(Arabidopsis
thaliana)
PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1)
5 ASP A 373
ALA A 363
ASP A 302
PHE A 303
SER A 308
None
0.97A 5hfjE-1u1hA:
undetectable
5hfjE-1u1hA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uhg OVALBUMIN

(Gallus gallus)
PF00079
(Serpin)
5 ALA A  39
ASP A  60
PHE A  59
GLY A  66
GLU A  70
None
1.32A 5hfjE-1uhgA:
undetectable
5hfjE-1uhgA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrm HYPOTHETICAL PROTEIN
TM1553


(Thermotoga
maritima)
PF02424
(ApbE)
5 ASP A  50
ALA A  52
GLY A 220
THR A 259
GLU A 217
None
1.25A 5hfjE-1vrmA:
undetectable
5hfjE-1vrmA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x1n 4-ALPHA-GLUCANOTRANS
FERASE


(Solanum
tuberosum)
PF02446
(Glyco_hydro_77)
5 ASP A  88
ALA A  89
PRO A 268
SER A 250
TYR A 248
None
1.03A 5hfjE-1x1nA:
undetectable
5hfjE-1x1nA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2akz GAMMA ENOLASE

(Homo sapiens)
PF00113
(Enolase_C)
PF03952
(Enolase_N)
5 ALA A 222
ASP A 244
PHE A 167
GLY A 155
SER A 156
None
MG  A 440 (-2.5A)
None
None
None
1.29A 5hfjE-2akzA:
undetectable
5hfjE-2akzA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b25 HYPOTHETICAL PROTEIN

(Homo sapiens)
PF08704
(GCD14)
5 ASP A 173
ASP A 192
GLY A 113
SER A 114
GLU A 135
SAM  A 601 (-3.4A)
SAM  A 601 (-3.5A)
SAM  A 601 (-3.2A)
SAM  A 601 (-4.8A)
SAM  A 601 (-2.9A)
1.11A 5hfjE-2b25A:
3.4
5hfjE-2b25A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3i OVOTRANSFERRIN

(Gallus gallus)
PF00405
(Transferrin)
5 ALA A 217
ASP A 292
GLY A 193
SER A 189
TYR A 188
None
1.28A 5hfjE-2d3iA:
undetectable
5hfjE-2d3iA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e28 PYRUVATE KINASE

(Geobacillus
stearothermophilus)
PF00224
(PK)
PF00391
(PEP-utilizers)
PF02887
(PK_C)
5 ALA A 278
SER A 284
THR A 292
GLU A 315
SER A 313
None
1.22A 5hfjE-2e28A:
undetectable
5hfjE-2e28A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2esr METHYLTRANSFERASE

(Streptococcus
pyogenes)
PF03602
(Cons_hypoth95)
6 ALA A 100
ASP A 117
PHE A  49
GLY A  51
SER A  52
GLU A  71
None
0.74A 5hfjE-2esrA:
3.6
5hfjE-2esrA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fhp METHYLASE, PUTATIVE

(Enterococcus
faecalis)
PF03602
(Cons_hypoth95)
5 ASP A  99
ALA A 100
ASP A 120
GLY A  51
SER A  52
None
0.77A 5hfjE-2fhpA:
6.5
5hfjE-2fhpA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fpo METHYLASE YHHF

(Escherichia
coli)
PF03602
(Cons_hypoth95)
6 ALA A 110
ASP A 127
PHE A  60
GLY A  62
SER A  63
GLU A  82
CL  A 401 (-3.8A)
None
None
None
None
None
0.78A 5hfjE-2fpoA:
3.8
5hfjE-2fpoA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ift PUTATIVE METHYLASE
HI0767


(Haemophilus
influenzae)
PF03602
(Cons_hypoth95)
5 ASP A 132
PHE A  61
GLY A  63
SER A  64
GLU A  83
None
1.26A 5hfjE-2iftA:
5.3
5hfjE-2iftA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipx RRNA
2'-O-METHYLTRANSFERA
SE FIBRILLARIN


(Homo sapiens)
PF01269
(Fibrillarin)
5 ASP A 217
ALA A 218
ASP A 237
THR A 173
GLU A 192
MTA  A4001 (-3.4A)
MTA  A4001 (-3.4A)
MTA  A4001 (-4.3A)
None
MTA  A4001 (-2.7A)
1.18A 5hfjE-2ipxA:
3.7
5hfjE-2ipxA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ker ALPHA-AMYLASE
INHIBITOR Z-2685


(Streptomyces
parvulus)
PF01356
(A_amylase_inhib)
5 ALA A  41
ASP A  20
PHE A  54
GLY A  56
TYR A  63
None
0.94A 5hfjE-2kerA:
undetectable
5hfjE-2kerA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mzw ELONGATION FACTOR G

(Staphylococcus
aureus)
PF00679
(EFG_C)
PF03764
(EFG_IV)
PF14492
(EFG_II)
5 ASP A 561
ALA A 555
ASP A 442
SER A 481
TYR A 482
None
1.24A 5hfjE-2mzwA:
undetectable
5hfjE-2mzwA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r1z BRCA1-ASSOCIATED
RING DOMAIN PROTEIN
1


(Homo sapiens)
PF00533
(BRCT)
PF16589
(BRCT_2)
5 PRO A 610
GLY A 576
SER A 575
THR A 617
SER A 579
None
1.02A 5hfjE-2r1zA:
undetectable
5hfjE-2r1zA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vgi PYRUVATE KINASE
ISOZYMES R/L


(Homo sapiens)
PF00224
(PK)
PF02887
(PK_C)
5 ALA A 370
SER A 376
THR A 384
GLU A 407
SER A 405
PGA  A1575 ( 4.9A)
None
None
None
PGA  A1575 ( 4.9A)
1.20A 5hfjE-2vgiA:
undetectable
5hfjE-2vgiA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wjs LAMININ SUBUNIT
ALPHA-2


(Mus musculus)
PF00054
(Laminin_G_1)
5 ASP A2288
ALA A2287
ASP A2268
GLY A2207
THR A2265
None
None
CA  A5001 (-3.2A)
CA  A5001 ( 4.3A)
None
1.31A 5hfjE-2wjsA:
undetectable
5hfjE-2wjsA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xqx ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE D


(Streptococcus
pneumoniae)
PF00754
(F5_F8_type_C)
5 ASP A 930
ALA A 937
GLY A 847
SER A 848
SER A 929
None
1.27A 5hfjE-2xqxA:
undetectable
5hfjE-2xqxA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN


(Pyrococcus
horikoshii)
PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N)
5 ALA A 322
ASP A 291
PRO A 339
PHE A 290
SER A 374
None
SFG  A5748 (-2.9A)
SFG  A5748 (-4.0A)
None
None
1.08A 5hfjE-2yxlA:
2.9
5hfjE-2yxlA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zie PUTATIVE
MODIFICATION
METHYLASE


(Thermus
thermophilus)
PF01555
(N6_N4_Mtase)
6 ASP A  28
ALA A  29
LYS A 219
PHE A 243
GLY A 245
GLU A 264
None
1.46A 5hfjE-2zieA:
20.4
5hfjE-2zieA:
26.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zie PUTATIVE
MODIFICATION
METHYLASE


(Thermus
thermophilus)
PF01555
(N6_N4_Mtase)
7 ASP A  28
ALA A  29
PHE A 243
GLY A 245
THR A 248
GLU A 264
TYR A 269
None
0.67A 5hfjE-2zieA:
20.4
5hfjE-2zieA:
26.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9t TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN


(Methylobacillus
flagellatus)
PF03069
(FmdA_AmdA)
5 ASP A 230
ALA A 231
GLY A 200
SER A 201
TYR A 227
None
1.27A 5hfjE-3b9tA:
undetectable
5hfjE-3b9tA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e05 PRECORRIN-6Y
C5,15-METHYLTRANSFER
ASE
(DECARBOXYLATING)


(Geobacter
metallireducens)
no annotation 5 ALA A 307
GLY A 258
SER A 259
GLU A 279
TYR A 284
None
CL  A   1 ( 4.7A)
CL  A   1 (-4.5A)
None
None
0.89A 5hfjE-3e05A:
3.8
5hfjE-3e05A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eoe PYRUVATE KINASE

(Toxoplasma
gondii)
PF00224
(PK)
PF02887
(PK_C)
5 ALA A 312
SER A 318
THR A 326
GLU A 349
SER A 347
None
1.22A 5hfjE-3eoeA:
undetectable
5hfjE-3eoeA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gu3 METHYLTRANSFERASE

(Bacillus cereus)
PF13847
(Methyltransf_31)
5 ASP A  97
ALA A  98
PHE A 115
GLY A  49
SER A  72
SAH  A 401 (-3.3A)
SAH  A 401 (-3.3A)
SAH  A 401 (-4.8A)
SAH  A 401 (-3.3A)
SAH  A 401 (-3.6A)
0.84A 5hfjE-3gu3A:
4.1
5hfjE-3gu3A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyx ADENYLYLSULFATE
REDUCTASE


(Desulfovibrio
gigas)
PF00890
(FAD_binding_2)
5 ALA A 626
PRO A 412
GLY A 553
THR A 548
TYR A 559
None
1.20A 5hfjE-3gyxA:
undetectable
5hfjE-3gyxA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khk TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLATION SUBUNIT


(Methanosarcina
mazei)
PF02384
(N6_Mtase)
PF12161
(HsdM_N)
5 ASP A 317
GLY A 253
SER A 254
GLU A 289
SER A 290
None
0.55A 5hfjE-3khkA:
2.8
5hfjE-3khkA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7i TEICHOIC ACID
BIOSYNTHESIS PROTEIN
F


(Staphylococcus
epidermidis)
PF04464
(Glyphos_transf)
5 ASP A 661
ASP A 629
PHE A 628
GLY A 631
TYR A 695
None
1.19A 5hfjE-3l7iA:
undetectable
5hfjE-3l7iA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldu PUTATIVE METHYLASE

(Clostridioides
difficile)
PF01170
(UPF0020)
PF02926
(THUMP)
5 ASP A 289
ALA A 290
GLY A 202
SER A 203
THR A 205
GTP  A 383 ( 3.8A)
GTP  A 383 (-3.7A)
GTP  A 383 (-2.6A)
GTP  A 383 (-2.7A)
GTP  A 383 (-3.5A)
0.45A 5hfjE-3lduA:
2.0
5hfjE-3lduA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mkq COATOMER
BETA'-SUBUNIT
COATOMER SUBUNIT
ALPHA


(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae)
PF00400
(WD40)
PF04053
(Coatomer_WDAD)
PF04053
(Coatomer_WDAD)
5 ALA A 769
LYS B 719
PHE A 770
GLY B 715
SER A 773
None
1.11A 5hfjE-3mkqA:
undetectable
5hfjE-3mkqA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ois CYSTEINE PROTEASE

(Xylella
fastidiosa)
PF00112
(Peptidase_C1)
5 ALA A  82
ASP A  71
GLY A  32
SER A  31
TYR A  33
None
1.27A 5hfjE-3oisA:
undetectable
5hfjE-3oisA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p9n POSSIBLE
METHYLTRANSFERASE
(METHYLASE)


(Mycobacterium
tuberculosis)
PF03602
(Cons_hypoth95)
6 ASP A 119
PRO A  17
GLY A  53
SER A  54
GLU A  73
SER A  74
None
1.18A 5hfjE-3p9nA:
3.3
5hfjE-3p9nA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pp7 PYRUVATE KINASE

(Leishmania
mexicana)
PF00224
(PK)
PF02887
(PK_C)
5 ALA A 295
SER A 301
THR A 309
GLU A 332
SER A 330
None
1.23A 5hfjE-3pp7A:
undetectable
5hfjE-3pp7A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qv9 PYRUVATE KINASE 2

(Trypanosoma
cruzi)
PF00224
(PK)
PF02887
(PK_C)
5 ALA A 296
SER A 302
THR A 310
GLU A 333
SER A 331
None
None
None
None
PO4  A 501 (-4.3A)
1.23A 5hfjE-3qv9A:
2.0
5hfjE-3qv9A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qxb PUTATIVE XYLOSE
ISOMERASE


(Rhodospirillum
rubrum)
PF01261
(AP_endonuc_2)
5 ASP A 139
ALA A 135
ASP A 123
SER A 118
THR A 165
None
1.04A 5hfjE-3qxbA:
undetectable
5hfjE-3qxbA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sgz HYDROXYACID OXIDASE
2


(Rattus
norvegicus)
PF01070
(FMN_dh)
5 ASP A   7
ALA A   6
LYS A 289
GLY A 284
GLU A 326
None
1.27A 5hfjE-3sgzA:
undetectable
5hfjE-3sgzA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t05 PYRUVATE KINASE

(Staphylococcus
aureus)
PF00224
(PK)
PF00391
(PEP-utilizers)
PF02887
(PK_C)
5 ALA A 276
SER A 282
THR A 290
GLU A 313
SER A 311
None
1.20A 5hfjE-3t05A:
undetectable
5hfjE-3t05A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tm5 CRYSTAL STRUCTURE OF
TRM14


(Pyrococcus
furiosus)
PF01170
(UPF0020)
PF02926
(THUMP)
6 ASP A 276
ALA A 277
GLY A 227
SER A 228
THR A 230
GLU A 248
SFG  A 401 (-3.4A)
SFG  A 401 (-3.1A)
SFG  A 401 ( 3.7A)
SFG  A 401 (-3.6A)
SFG  A 401 (-3.3A)
SFG  A 401 (-2.6A)
0.57A 5hfjE-3tm5A:
5.8
5hfjE-3tm5A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tma METHYLTRANSFERASE

(Thermus
thermophilus)
PF01170
(UPF0020)
PF02926
(THUMP)
5 ASP A 243
ALA A 244
PHE A 192
GLY A 194
SER A 195
None
0.68A 5hfjE-3tmaA:
3.5
5hfjE-3tmaA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tma METHYLTRANSFERASE

(Thermus
thermophilus)
PF01170
(UPF0020)
PF02926
(THUMP)
5 ASP A 243
ALA A 244
PHE A 192
GLY A 194
THR A 197
None
0.72A 5hfjE-3tmaA:
3.5
5hfjE-3tmaA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8v RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L


(Escherichia
coli)
PF01170
(UPF0020)
PF02926
(THUMP)
PF10672
(Methyltrans_SAM)
5 ASP A 290
GLY A 199
SER A 200
THR A 202
SER A 263
SAM  A 801 (-3.0A)
SAM  A 801 (-3.2A)
SAM  A 801 (-3.0A)
SAM  A 801 (-4.1A)
SAM  A 801 (-3.5A)
0.61A 5hfjE-3v8vA:
3.5
5hfjE-3v8vA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vyw MNMC2

(Aquifex
aeolicus)
PF05430
(Methyltransf_30)
5 ASP A 174
ALA A 175
ASP A 193
GLY A 106
GLU A 133
SAM  A 501 (-3.4A)
SAM  A 501 (-3.8A)
SAM  A 501 (-3.8A)
SAM  A 501 (-3.3A)
SAM  A 501 (-2.3A)
0.76A 5hfjE-3vywA:
5.3
5hfjE-3vywA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wvo CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY


(Thermobifida
fusca)
PF09481
(CRISPR_Cse1)
5 ASP A 374
ALA A 475
GLY A 414
SER A 413
GLU A 410
None
1.24A 5hfjE-3wvoA:
undetectable
5hfjE-3wvoA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zsc PECTATE
TRISACCHARIDE-LYASE


(Thermotoga
maritima)
PF00544
(Pec_lyase_C)
5 ASP A 139
LYS A 163
PHE A 116
GLY A 137
TYR A 104
AQA  A1338 (-3.9A)
AQA  A1338 (-3.0A)
None
None
None
1.03A 5hfjE-3zscA:
undetectable
5hfjE-3zscA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b4d FERREDOXIN-NADP
REDUCTASE


(Xanthomonas
citri)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6)
6 ASP A 211
ALA A 213
GLY A 248
SER A 241
THR A 246
TYR A 250
None
1.24A 5hfjE-4b4dA:
2.8
5hfjE-4b4dA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cns DIHYDROPYRIMIDINASE-
LIKE 3


(Homo sapiens)
PF01979
(Amidohydro_1)
5 ALA A  98
ASP A 408
LYS A 398
GLY A  69
SER A 385
None
1.32A 5hfjE-4cnsA:
undetectable
5hfjE-4cnsA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4df3 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE


(Aeropyrum
pernix)
PF01269
(Fibrillarin)
5 ALA A 135
ASP A 154
SER A  88
THR A  90
GLU A 109
SAM  A 301 (-3.5A)
SAM  A 301 (-3.6A)
None
SAM  A 301 (-3.9A)
SAM  A 301 (-2.9A)
1.30A 5hfjE-4df3A:
4.0
5hfjE-4df3A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4df3 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE


(Aeropyrum
pernix)
PF01269
(Fibrillarin)
5 ASP A 134
ALA A 135
SER A  88
THR A  90
GLU A 109
SAM  A 301 (-3.3A)
SAM  A 301 (-3.5A)
None
SAM  A 301 (-3.9A)
SAM  A 301 (-2.9A)
0.79A 5hfjE-4df3A:
4.0
5hfjE-4df3A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4drs PYRUVATE KINASE

(Cryptosporidium
parvum)
PF00224
(PK)
PF02887
(PK_C)
5 ALA A 327
SER A 333
THR A 341
GLU A 364
SER A 362
None
None
None
None
GOL  A 603 ( 3.4A)
1.19A 5hfjE-4drsA:
undetectable
5hfjE-4drsA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewp 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3


(Micrococcus
luteus)
PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III)
5 ALA A 102
PRO A 313
GLY A 149
THR A 307
TYR A 126
None
1.20A 5hfjE-4ewpA:
undetectable
5hfjE-4ewpA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fix UDP-GALACTOFURANOSYL
TRANSFERASE GLFT2


(Mycobacterium
tuberculosis)
PF13641
(Glyco_tranf_2_3)
5 ASP A 199
LYS A 369
PHE A 169
GLY A 232
TYR A 236
None
1.29A 5hfjE-4fixA:
undetectable
5hfjE-4fixA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fix UDP-GALACTOFURANOSYL
TRANSFERASE GLFT2


(Mycobacterium
tuberculosis)
PF13641
(Glyco_tranf_2_3)
5 LYS A 369
PHE A 169
GLY A 232
SER A 233
TYR A 236
None
1.30A 5hfjE-4fixA:
undetectable
5hfjE-4fixA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gw9 BACTERIOPHYTOCHROME

(Rhodopseudomonas
palustris)
PF00360
(PHY)
PF00989
(PAS)
PF01590
(GAF)
PF08446
(PAS_2)
5 ALA A 422
ASP A 406
GLY A 419
SER A 418
THR A 414
None
1.19A 5hfjE-4gw9A:
undetectable
5hfjE-4gw9A:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gz7 DIHYDROPYRIMIDINASE

(Tetraodon
nigroviridis)
PF01979
(Amidohydro_1)
5 ALA A  88
ASP A 398
LYS A 388
GLY A  59
SER A 375
None
1.27A 5hfjE-4gz7A:
undetectable
5hfjE-4gz7A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hyv PYRUVATE KINASE 1

(Trypanosoma
brucei)
PF00224
(PK)
PF02887
(PK_C)
5 ALA A 296
SER A 302
THR A 310
GLU A 333
SER A 331
PEP  A1003 ( 3.9A)
None
None
None
PEP  A1003 ( 4.9A)
1.20A 5hfjE-4hyvA:
undetectable
5hfjE-4hyvA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j1s POLYKETIDE SYNTHASE
PKSJ


(Bacillus
subtilis)
PF08659
(KR)
5 ALA A  61
ASP A 338
PHE A 336
GLY A 104
SER A 106
None
1.32A 5hfjE-4j1sA:
2.4
5hfjE-4j1sA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l1g PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE


(Bacillus cereus)
PF01522
(Polysacc_deac_1)
5 ASP A  84
PRO A 165
LYS A 264
PHE A 104
GLY A 129
None
1.31A 5hfjE-4l1gA:
undetectable
5hfjE-4l1gA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p4o DNA POLYMERASE BETA

(Leishmania
infantum)
PF10391
(DNA_pol_lambd_f)
PF14716
(HHH_8)
PF14791
(DNA_pol_B_thumb)
PF14792
(DNA_pol_B_palm)
5 ALA A 283
ASP A 271
PHE A 287
GLY A 183
SER A 184
None
None
None
D3T  A 401 (-3.2A)
D3T  A 401 (-2.5A)
1.10A 5hfjE-4p4oA:
undetectable
5hfjE-4p4oA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q0c VIRULENCE SENSOR
PROTEIN BVGS


(Bordetella
pertussis)
PF00497
(SBP_bac_3)
5 PRO A 319
SER A 465
THR A 462
SER A 528
TYR A 468
None
1.13A 5hfjE-4q0cA:
undetectable
5hfjE-4q0cA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rv3 1-PHOSPHATIDYLINOSIT
OL PHOSPHODIESTERASE


(Staphylococcus
aureus)
PF00388
(PI-PLC-X)
5 ALA A  96
ASP A  65
GLY A  33
SER A  34
THR A  48
None
1.06A 5hfjE-4rv3A:
undetectable
5hfjE-4rv3A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u7t DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A


(Homo sapiens)
PF00145
(DNA_methylase)
5 ASP A 686
PHE A 640
GLY A 642
THR A 645
GLU A 664
SAH  A1004 (-3.0A)
SAH  A1004 (-4.6A)
SAH  A1004 (-3.3A)
SAH  A1004 (-3.3A)
SAH  A1004 (-3.0A)
0.71A 5hfjE-4u7tA:
undetectable
5hfjE-4u7tA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xqk LLABIII

(Lactococcus
lactis)
PF00271
(Helicase_C)
PF02384
(N6_Mtase)
PF04851
(ResIII)
PF13156
(Mrr_cat_2)
5 ASP A 981
PHE A 904
GLY A 906
THR A 909
GLU A 944
None
0.72A 5hfjE-4xqkA:
2.9
5hfjE-4xqkA:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuo ENDO-1,4-BETA-XYLANA
SE C


(Paenibacillus
barcinonensis)
PF02018
(CBM_4_9)
5 ASP A 141
ALA A 144
SER A  59
THR A  25
TYR A 136
None
1.20A 5hfjE-4xuoA:
undetectable
5hfjE-4xuoA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xup ENDO-1,4-BETA-XYLANA
SE C


(Paenibacillus
barcinonensis)
PF02018
(CBM_4_9)
5 ASP A 141
ALA A 144
SER A  59
THR A  25
TYR A 136
None
1.22A 5hfjE-4xupA:
undetectable
5hfjE-4xupA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yj5 PYRUVATE KINASE PKM

(Homo sapiens)
PF00224
(PK)
PF02887
(PK_C)
5 ALA A 327
SER A 333
THR A 341
GLU A 364
SER A 362
PYR  A 601 ( 4.5A)
None
None
None
None
1.24A 5hfjE-4yj5A:
undetectable
5hfjE-4yj5A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yvd PLEIOTROPIC
REGULATOR 1


(Homo sapiens)
PF00400
(WD40)
5 ALA A 431
ASP A 393
GLY A 390
SER A 389
SER A 429
None
1.30A 5hfjE-4yvdA:
undetectable
5hfjE-4yvdA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zcf RESTRICTION
ENDONUCLEASE
ECOP15I,
MODIFICATION SUBUNIT


(Escherichia
coli)
PF01555
(N6_N4_Mtase)
7 ASP A 101
ASP A 123
LYS A 418
PHE A 441
GLY A 443
SER A 444
THR A 446
None
0.79A 5hfjE-4zcfA:
18.7
5hfjE-4zcfA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bqs 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3


(Streptococcus
pneumoniae)
PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III)
5 ALA A  79
GLY A 310
SER A 309
THR A 319
SER A 281
None
None
None
None
4VN  A 402 ( 4.9A)
1.30A 5hfjE-5bqsA:
undetectable
5hfjE-5bqsA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csu 4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC


(Arabidopsis
thaliana)
PF02446
(Glyco_hydro_77)
5 ASP A 140
ALA A 141
PRO A 320
SER A 302
TYR A 300
None
1.10A 5hfjE-5csuA:
undetectable
5hfjE-5csuA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e72 N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE


(Thermococcus
kodakarensis)
PF01170
(UPF0020)
PF02926
(THUMP)
5 ASP A 235
ALA A 236
ASP A 254
PHE A 187
GLY A 189
SAM  A 400 (-3.4A)
SAM  A 400 (-3.5A)
None
SAM  A 400 (-4.7A)
SAM  A 400 (-3.3A)
0.59A 5hfjE-5e72A:
5.6
5hfjE-5e72A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f9s SERINE--PYRUVATE
AMINOTRANSFERASE


(Homo sapiens)
PF00266
(Aminotran_5)
5 PRO A 353
GLY A 106
THR A 127
GLU A 157
SER A 158
None
None
None
None
PLP  A 401 (-1.8A)
1.13A 5hfjE-5f9sA:
undetectable
5hfjE-5f9sA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ffj ENDONUCLEASE AND
METHYLASE LLAGI


(Lactococcus
lactis)
PF00271
(Helicase_C)
PF02384
(N6_Mtase)
PF04851
(ResIII)
5 ASP A 981
PHE A 904
GLY A 906
THR A 909
GLU A 944
None
0.90A 5hfjE-5ffjA:
2.9
5hfjE-5ffjA:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gin FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE


(Sulfolobus
solfataricus)
PF01269
(Fibrillarin)
5 ASP E 133
ALA E 134
ASP E 153
THR E  89
GLU E 108
SAH  E 301 (-3.5A)
SAH  E 301 (-3.6A)
SAH  E 301 (-3.7A)
A  I   6 ( 3.5A)
SAH  E 301 (-3.0A)
1.31A 5hfjE-5ginE:
3.5
5hfjE-5ginE:
21.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hfj ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA)


(Helicobacter
pylori)
PF01555
(N6_N4_Mtase)
10 ASP A   8
ALA A   9
ASP A  29
PHE A 195
GLY A 197
SER A 198
THR A 200
GLU A 216
SER A 217
TYR A 221
SAM  A 301 (-3.4A)
SAM  A 301 (-3.2A)
SAM  A 301 (-3.2A)
SAM  A 301 (-4.6A)
SAM  A 301 (-3.4A)
SAM  A 301 (-2.5A)
SAM  A 301 (-3.6A)
SAM  A 301 (-3.1A)
SAM  A 301 (-2.8A)
SAM  A 301 (-4.2A)
0.33A 5hfjE-5hfjA:
32.9
5hfjE-5hfjA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i5d INNER MEMBRANE
PROTEIN YEJM


(Salmonella
enterica)
PF00884
(Sulfatase)
PF11893
(DUF3413)
5 ASP A 303
ASP A 490
GLY A 312
SER A 513
THR A 496
None
1.31A 5hfjE-5i5dA:
undetectable
5hfjE-5i5dA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6b ALDEHYDE
DEHYDROGENASE


(Burkholderia
thailandensis)
PF00171
(Aldedh)
5 ALA A 254
GLY A 282
SER A 281
SER A 438
TYR A 279
None
1.32A 5hfjE-5j6bA:
undetectable
5hfjE-5j6bA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jkp UNCHARACTERIZED
PROTEIN


(Pseudomonas
aeruginosa)
PF08238
(Sel1)
5 ASP A 138
ALA A 136
ASP A 121
PHE A 119
GLY A 123
None
1.32A 5hfjE-5jkpA:
undetectable
5hfjE-5jkpA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqs BETA-L-ARABINOBIOSID
ASE


(Bacteroides
thetaiotaomicron)
PF13088
(BNR_2)
5 ASP A 491
ASP A 453
PRO A 437
SER A 436
TYR A 435
None
CA  A1203 (-2.4A)
None
None
None
1.25A 5hfjE-5mqsA:
undetectable
5hfjE-5mqsA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wrp PYRUVATE KINASE

(Mycobacterium
tuberculosis)
no annotation 5 ALA A 275
SER A 281
THR A 289
GLU A 312
SER A 310
None
1.24A 5hfjE-5wrpA:
undetectable
5hfjE-5wrpA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xh9 EXTRACELLULAR
INVERTASE


(Aspergillus
kawachii)
PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C)
5 ALA A 119
ASP A 194
PHE A 121
GLY A 123
SER A 124
None
1.19A 5hfjE-5xh9A:
undetectable
5hfjE-5xh9A:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi GUANINE
NUCLEOTIDE-BINDING
PROTEIN BETA
SUBUNIT, PUTATIVE


(Trichomonas
vaginalis)
no annotation 5 ASP g  54
ALA g  34
GLY g 321
SER g 320
SER g  52
G  21218 ( 4.9A)
None
None
None
None
1.27A 5hfjE-5xyig:
undetectable
5hfjE-5xyig:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ya1 AUTOINDUCER-2 KINASE

(Escherichia
coli)
no annotation 5 ASP A 216
ALA A 215
ASP A 186
PRO A 298
GLY A 191
None
1.28A 5hfjE-5ya1A:
undetectable
5hfjE-5ya1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6brr DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A


(Homo sapiens)
no annotation 5 ASP A 686
PHE A 640
GLY A 642
THR A 645
GLU A 664
SAH  A1001 (-3.0A)
SAH  A1001 (-4.4A)
SAH  A1001 (-3.4A)
SAH  A1001 (-3.5A)
SAH  A1001 (-2.7A)
0.60A 5hfjE-6brrA:
2.5
5hfjE-6brrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g3u -

(-)
no annotation 5 ASP A  13
ASP A 548
GLY A 583
SER A 562
SER A 585
None
AKG  A 802 (-3.7A)
NAP  A 801 (-4.1A)
None
NAP  A 801 (-3.4A)
1.09A 5hfjE-6g3uA:
undetectable
5hfjE-6g3uA:
undetectable