SIMILAR PATTERNS OF AMINO ACIDS FOR 5HFJ_C_SAMC301_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yi7 BETA-XYLOSIDASE,
FAMILY 43 GLYCOSYL
HYDROLASE

(Clostridium
acetobutylicum) 		PF04616
(Glyco_hydro_43) 		4 ASP A  15
HIS A 190
SER A 251
GLU A 213
 GOL  A3020 (-2.6A)
None
None
None
 1.24A 5hfjC-1yi7A:
0.0		 5hfjC-1yi7A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a3l AMP DEAMINASE

(Arabidopsis
thaliana) 		PF00962
(A_deaminase) 		4 ASP A 737
HIS A 391
SER A 705
GLU A 662
 CF5  A 841 (-2.5A)
ZN  A 840 ( 3.2A)
None
CF5  A 841 (-2.6A)
 1.05A 5hfjC-2a3lA:
0.0		 5hfjC-2a3lA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ef4 ARGINASE

(Thermus
thermophilus) 		PF00491
(Arginase) 		4 ASP A  12
HIS A 136
SER A  98
GLU A 263
 None
 1.33A 5hfjC-2ef4A:
4.7		 5hfjC-2ef4A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okk GLUTAMATE
DECARBOXYLASE 2

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		4 ASP A 305
HIS A 280
SER A 278
GLU A 279
 None
 1.19A 5hfjC-2okkA:
0.0		 5hfjC-2okkA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c2u XYLOSIDASE/ARABINOSI
DASE

(Selenomonas
ruminantium) 		PF04616
(Glyco_hydro_43)
PF07081
(DUF1349) 		4 ASP A  14
HIS A 189
SER A 250
GLU A 212
 B3P  A 539 (-2.7A)
None
None
None
 1.23A 5hfjC-3c2uA:
0.0		 5hfjC-3c2uA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4buc UDP-N-ACETYLMURAMOYL
ALANINE--D-GLUTAMATE
LIGASE

(Thermotoga
maritima) 		PF08245
(Mur_ligase_M) 		4 ASP A  94
HIS A 205
SER A 206
GLU A 210
 None
 1.03A 5hfjC-4bucA:
2.7		 5hfjC-4bucA:
18.81