SIMILAR PATTERNS OF AMINO ACIDS FOR 5HFJ_A_SAMA301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aow ANNEXIN IV

(Bos taurus) 		PF00191
(Annexin) 		5 ASP A 218
GLY A 181
THR A 187
GLU A 226
SER A 222
 None
 1.14A 5hfjA-1aowA:
undetectable		 5hfjA-1aowA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bgp BARLEY GRAIN
PEROXIDASE

(Hordeum vulgare) 		PF00141
(peroxidase) 		5 ALA A 184
PRO A 151
PHE A 247
THR A 200
GLU A 190
 HEM  A 400 (-4.0A)
HEM  A 400 (-4.1A)
HEM  A 400 (-4.4A)
None
None
 0.85A 5hfjA-1bgpA:
undetectable		 5hfjA-1bgpA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bhe POLYGALACTURONASE

(Pectobacterium
carotovorum) 		PF00295
(Glyco_hydro_28) 		5 ALA A 105
PHE A 162
GLY A 184
THR A 213
SER A 159
 None
 1.37A 5hfjA-1bheA:
undetectable		 5hfjA-1bheA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1boo PROTEIN (N-4
CYTOSINE-SPECIFIC
METHYLTRANSFERASE
PVU II)

(Proteus
vulgaris) 		PF01555
(N6_N4_Mtase) 		6 ASP A  34
PRO A  55
PHE A 273
GLY A 274
THR A 278
GLU A 294
 SAH  A 401 (-4.0A)
SAH  A 401 (-3.9A)
SAH  A 401 (-4.6A)
None
SAH  A 401 (-4.0A)
SAH  A 401 (-2.9A)
 1.18A 5hfjA-1booA:
20.1		 5hfjA-1booA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1boo PROTEIN (N-4
CYTOSINE-SPECIFIC
METHYLTRANSFERASE
PVU II)

(Proteus
vulgaris) 		PF01555
(N6_N4_Mtase) 		7 ASP A  34
PRO A  55
PHE A 273
GLY A 275
THR A 278
GLU A 294
TYR A 299
 SAH  A 401 (-4.0A)
SAH  A 401 (-3.9A)
SAH  A 401 (-4.6A)
SAH  A 401 (-3.5A)
SAH  A 401 (-4.0A)
SAH  A 401 (-2.9A)
SAH  A 401 (-4.2A)
 0.63A 5hfjA-1booA:
20.1		 5hfjA-1booA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1c METHYLMALONYL-COA
MUTASE ALPHA CHAIN

(Propionibacterium
freudenreichii) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding) 		5 ALA A 715
ASP A 627
PRO A 598
PHE A 626
GLU A 588
 None
 1.26A 5hfjA-1e1cA:
undetectable		 5hfjA-1e1cA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eye DIHYDROPTEROATE
SYNTHASE I

(Mycobacterium
tuberculosis) 		PF00809
(Pterin_bind) 		5 ASP A  27
ALA A  31
PRO A  71
GLY A  50
THR A  87
 None
 1.27A 5hfjA-1eyeA:
undetectable		 5hfjA-1eyeA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fbn MJ FIBRILLARIN
HOMOLOGUE

(Methanocaldococcus
jannaschii) 		PF01269
(Fibrillarin) 		5 ASP A 130
ALA A 131
ASP A 150
THR A  88
GLU A 105
 None
 1.09A 5hfjA-1fbnA:
3.0		 5hfjA-1fbnA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g60 ADENINE-SPECIFIC
METHYLTRANSFERASE
MBOIIA

(Moraxella bovis) 		PF01555
(N6_N4_Mtase) 		5 ASP A  30
PHE A 220
GLY A 222
THR A 225
TYR A 246
 SAM  A 500 (-3.7A)
SAM  A 500 (-4.6A)
SAM  A 500 (-3.2A)
SAM  A 500 (-3.4A)
SAM  A 500 (-4.4A)
 0.44A 5hfjA-1g60A:
22.9		 5hfjA-1g60A:
29.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g60 ADENINE-SPECIFIC
METHYLTRANSFERASE
MBOIIA

(Moraxella bovis) 		PF01555
(N6_N4_Mtase) 		5 ASP A  30
PRO A  32
PHE A 220
GLY A 222
THR A 225
 SAM  A 500 (-3.7A)
None
SAM  A 500 (-4.6A)
SAM  A 500 (-3.2A)
SAM  A 500 (-3.4A)
 0.65A 5hfjA-1g60A:
22.9		 5hfjA-1g60A:
29.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gae D-GLYCERALDEHYDE-3-P
HOSPHATE
DEHYDROGENASE

(Escherichia
coli) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 ALA O 294
PHE O 292
GLY O 272
THR O 289
GLU O 264
 None
 1.11A 5hfjA-1gaeO:
undetectable		 5hfjA-1gaeO:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k32 TRICORN PROTEASE

(Thermoplasma
acidophilum) 		PF03572
(Peptidase_S41)
PF07676
(PD40)
PF14684
(Tricorn_C1)
PF14685
(Tricorn_PDZ) 		5 ASP A 811
ALA A 833
ASP A 853
GLY A 763
GLU A 827
 None
 1.10A 5hfjA-1k32A:
undetectable		 5hfjA-1k32A:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nku 3-METHYLADENINE DNA
GLYCOSYLASE I (TAG)

(Escherichia
coli) 		PF03352
(Adenine_glyco) 		5 ALA A 148
ASP A 114
PHE A 115
THR A  26
TYR A 102
 None
 1.24A 5hfjA-1nkuA:
undetectable		 5hfjA-1nkuA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nt2 FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN

(Archaeoglobus
fulgidus) 		PF01269
(Fibrillarin) 		5 ASP A 113
ALA A 114
ASP A 133
THR A  70
GLU A  88
 SAM  A 301 (-3.6A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.1A)
SAM  A 301 (-2.4A)
 0.98A 5hfjA-1nt2A:
4.0		 5hfjA-1nt2A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nw5 MODIFICATION
METHYLASE RSRI

(Rhodobacter
sphaeroides) 		PF01555
(N6_N4_Mtase) 		5 ASP A  46
ASP A  65
PRO A  67
PHE A 250
GLY A 252
 SAM  A 401 (-3.6A)
SAM  A 401 (-3.3A)
SAM  A 401 (-4.3A)
SAM  A 401 (-4.7A)
SAM  A 401 (-3.3A)
 0.52A 5hfjA-1nw5A:
21.5		 5hfjA-1nw5A:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qub PROTEIN (HUMAN
BETA2-GLYCOPROTEIN
I)

(Homo sapiens) 		PF00084
(Sushi)
PF09014
(Sushi_2) 		5 ALA A  68
PRO A 116
PHE A  89
GLY A  74
GLU A  72
 None
 1.34A 5hfjA-1qubA:
undetectable		 5hfjA-1qubA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qxo CHORISMATE SYNTHASE

(Streptococcus
pneumoniae) 		PF01264
(Chorismate_synt) 		5 ALA A  90
GLY A   7
THR A   5
GLU A   8
GLU A 129
 None
 1.38A 5hfjA-1qxoA:
undetectable		 5hfjA-1qxoA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qyr HIGH LEVEL
KASUGAMYCIN
RESISTANCE PROTEIN

(Escherichia
coli) 		PF00398
(RrnaAD) 		5 ASP A  91
ALA A  92
PRO A 115
GLY A  47
GLU A  66
 None
 0.88A 5hfjA-1qyrA:
3.3		 5hfjA-1qyrA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rp0 THIAZOLE
BIOSYNTHETIC ENZYME

(Arabidopsis
thaliana) 		PF01946
(Thi4) 		5 ALA A 161
PHE A 193
GLY A  46
GLU A  70
SER A  72
 None
AHZ  A 600 (-4.7A)
AHZ  A 600 (-3.1A)
AHZ  A 600 (-2.7A)
None
 1.33A 5hfjA-1rp0A:
undetectable		 5hfjA-1rp0A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqj OLIGOXYLOGLUCAN
REDUCING-END-SPECIFI
C CELLOBIOHYDROLASE

(Geotrichum sp.
M128) 		PF15899
(BNR_6) 		5 ASP A 716
ALA A 697
PHE A 699
THR A 676
TYR A 713
 None
 1.06A 5hfjA-1sqjA:
undetectable		 5hfjA-1sqjA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1twl INORGANIC
PYROPHOSPHATASE

(Pyrococcus
furiosus) 		PF00719
(Pyrophosphatase) 		5 ASP A  34
PRO A  69
GLY A  57
GLU A  22
TYR A  56
 None
 1.10A 5hfjA-1twlA:
undetectable		 5hfjA-1twlA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uhg OVALBUMIN

(Gallus gallus) 		PF00079
(Serpin) 		5 ALA A  39
ASP A  60
PHE A  59
GLY A  66
GLU A  70
 None
 1.34A 5hfjA-1uhgA:
undetectable		 5hfjA-1uhgA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vol PROTEIN
(TRANSCRIPTION
FACTOR IIB (TFIIB))

(Homo sapiens) 		PF00382
(TFIIB) 		5 ASP A 157
ALA A 155
GLY A 192
SER A 161
TYR A 165
 None
 1.36A 5hfjA-1volA:
undetectable		 5hfjA-1volA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wd5 HYPOTHETICAL PROTEIN
TT1426

(Thermus
thermophilus) 		PF00156
(Pribosyltran) 		5 ALA A 131
ASP A 180
PRO A 178
PHE A 181
GLU A 161
 None
 1.24A 5hfjA-1wd5A:
2.0		 5hfjA-1wd5A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpm PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1)

(Streptococcus
pneumoniae) 		PF02086
(MethyltransfD12) 		5 ASP A 177
ASP A 194
PRO A 196
PHE A  43
GLY A  45
 SAM  A 300 (-4.1A)
SAM  A 300 (-3.7A)
SAM  A 300 ( 4.1A)
SAM  A 300 (-4.2A)
SAM  A 300 (-3.6A)
 1.21A 5hfjA-2dpmA:
3.2		 5hfjA-2dpmA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2esr METHYLTRANSFERASE

(Streptococcus
pyogenes) 		PF03602
(Cons_hypoth95) 		6 ALA A 100
ASP A 117
PRO A 119
PHE A  49
GLY A  51
GLU A  71
 None
 0.71A 5hfjA-2esrA:
3.6		 5hfjA-2esrA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fhp METHYLASE, PUTATIVE

(Enterococcus
faecalis) 		PF03602
(Cons_hypoth95) 		5 ASP A  99
ALA A 100
ASP A 120
PRO A 122
GLY A  51
 None
 1.02A 5hfjA-2fhpA:
4.5		 5hfjA-2fhpA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fl1 RED FLUORESCENT
PROTEIN ZOANRFP

(Zoanthus sp.) 		PF01353
(GFP) 		5 ALA A  63
ASP A 182
PHE A 181
GLY A 163
GLU A 150
 XYG  A  66 ( 4.0A)
None
None
None
XYG  A  66 ( 4.6A)
 1.19A 5hfjA-2fl1A:
undetectable		 5hfjA-2fl1A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fpo METHYLASE YHHF

(Escherichia
coli) 		PF03602
(Cons_hypoth95) 		6 ALA A 110
ASP A 127
PRO A 129
PHE A  60
GLY A  62
GLU A  82
 CL  A 401 (-3.8A)
None
None
None
None
None
 0.88A 5hfjA-2fpoA:
3.2		 5hfjA-2fpoA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ha9 UPF0210 PROTEIN
SP0239

(Streptococcus
pneumoniae) 		PF05167
(DUF711) 		5 ALA A 188
PRO A  79
PHE A 199
GLY A 112
SER A 146
 None
 1.30A 5hfjA-2ha9A:
undetectable		 5hfjA-2ha9A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9k MODIFICATION
METHYLASE HHAI

(Haemophilus
haemolyticus) 		PF00145
(DNA_methylase) 		5 ASP A  60
PRO A  80
PHE A  18
GLY A  20
GLU A  40
 SAH  A 328 (-3.6A)
SAH  A 328 (-4.0A)
SAH  A 328 (-4.9A)
SAH  A 328 (-3.3A)
SAH  A 328 (-2.8A)
 0.53A 5hfjA-2i9kA:
6.6		 5hfjA-2i9kA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2igt SAM DEPENDENT
METHYLTRANSFERASE

(Agrobacterium
fabrum) 		PF10672
(Methyltrans_SAM) 		5 ASP A 190
ASP A 211
PRO A 213
PHE A 140
GLY A 141
 SAM  A1001 (-3.7A)
SAM  A1001 (-2.8A)
SAM  A1001 (-3.2A)
SAM  A1001 (-4.4A)
None
 1.13A 5hfjA-2igtA:
3.3		 5hfjA-2igtA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipx RRNA
2'-O-METHYLTRANSFERA
SE FIBRILLARIN

(Homo sapiens) 		PF01269
(Fibrillarin) 		5 ASP A 217
ALA A 218
ASP A 237
THR A 174
GLU A 192
 MTA  A4001 (-3.4A)
MTA  A4001 (-3.4A)
MTA  A4001 (-4.3A)
None
MTA  A4001 (-2.7A)
 0.92A 5hfjA-2ipxA:
3.7		 5hfjA-2ipxA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjq UNCHARACTERIZED RNA
METHYLTRANSFERASE
PYRAB10780

(Pyrococcus
abyssi) 		PF05958
(tRNA_U5-meth_tr) 		5 ASP A 340
PRO A 342
GLY A 280
THR A 283
SER A 300
 SAH  A1406 (-3.8A)
SAH  A1406 (-4.1A)
SAH  A1406 (-3.4A)
SAH  A1406 (-3.4A)
SAH  A1406 (-2.9A)
 0.97A 5hfjA-2jjqA:
3.1		 5hfjA-2jjqA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wjs LAMININ SUBUNIT
ALPHA-2

(Mus musculus) 		PF00054
(Laminin_G_1) 		5 ASP A2288
ALA A2287
ASP A2268
GLY A2207
THR A2265
 None
None
CA  A5001 (-3.2A)
CA  A5001 ( 4.3A)
None
 1.25A 5hfjA-2wjsA:
undetectable		 5hfjA-2wjsA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wvg PYRUVATE
DECARBOXYLASE

(Zymomonas
mobilis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 ASP A  82
PRO A 420
GLY A  59
GLU A  58
GLU A 409
 None
 1.26A 5hfjA-2wvgA:
undetectable		 5hfjA-2wvgA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zie PUTATIVE
MODIFICATION
METHYLASE

(Thermus
thermophilus) 		PF01555
(N6_N4_Mtase) 		8 ASP A  28
ALA A  29
PRO A  49
PHE A 243
GLY A 245
THR A 248
GLU A 264
TYR A 269
 None
 0.69A 5hfjA-2zieA:
19.6		 5hfjA-2zieA:
26.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus musculus) 		PF00145
(DNA_methylase)
PF01426
(BAH)
PF02008
(zf-CXXC)
PF12047
(DNMT1-RFD) 		5 ASP A1193
PRO A1228
PHE A1148
GLY A1150
GLU A1171
 SAM  A   1 (-3.6A)
SAM  A   1 ( 4.2A)
SAM  A   1 (-4.9A)
SAM  A   1 ( 3.9A)
SAM  A   1 (-2.6A)
 0.59A 5hfjA-3av6A:
undetectable		 5hfjA-3av6A:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bc8 O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE

(Mus musculus) 		PF05889
(SepSecS) 		5 ASP A 283
PRO A 289
GLY A 292
THR A 144
SER A 317
 LLP  A 284 ( 3.2A)
None
None
LLP  A 284 ( 4.4A)
EDO  A 502 (-3.1A)
 1.23A 5hfjA-3bc8A:
2.2		 5hfjA-3bc8A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gry DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococcus
jannaschii) 		PF00398
(RrnaAD) 		5 ASP A  84
ALA A  85
PRO A 103
GLY A  40
GLU A  59
 SAM  A 300 (-3.7A)
SAM  A 300 (-3.6A)
SAM  A 300 (-3.8A)
SAM  A 300 (-3.3A)
SAM  A 300 (-2.8A)
 1.17A 5hfjA-3gryA:
3.6		 5hfjA-3gryA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jsa HOMOSERINE
DEHYDROGENASE

(Thermoplasma
volcanium) 		PF00742
(Homoserine_dh)
PF03447
(NAD_binding_3) 		5 ALA A  79
ASP A  89
PHE A   9
GLY A  10
SER A  46
 None
None
None
NAD  A 501 (-3.4A)
None
 1.32A 5hfjA-3jsaA:
undetectable		 5hfjA-3jsaA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khk TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLATION SUBUNIT

(Methanosarcina
mazei) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		5 ASP A 317
PRO A 337
GLY A 253
GLU A 289
SER A 290
 None
 0.63A 5hfjA-3khkA:
2.9		 5hfjA-3khkA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7i TEICHOIC ACID
BIOSYNTHESIS PROTEIN
F

(Staphylococcus
epidermidis) 		PF04464
(Glyphos_transf) 		5 ASP A 661
ASP A 629
PHE A 628
GLY A 631
TYR A 695
 None
 1.13A 5hfjA-3l7iA:
2.6		 5hfjA-3l7iA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ld3 INORGANIC
PYROPHOSPHATASE

(Anaplasma
phagocytophilum) 		PF00719
(Pyrophosphatase) 		5 ASP A  34
PRO A  69
GLY A  57
GLU A  21
GLU A  32
 None
None
None
None
PO4  A 200 ( 4.6A)
 1.07A 5hfjA-3ld3A:
undetectable		 5hfjA-3ld3A:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldu PUTATIVE METHYLASE

(Clostridioides
difficile) 		PF01170
(UPF0020)
PF02926
(THUMP) 		5 ASP A 289
ALA A 290
PRO A 307
GLY A 202
THR A 205
 GTP  A 383 ( 3.8A)
GTP  A 383 (-3.7A)
GTP  A 383 (-3.7A)
GTP  A 383 (-2.6A)
GTP  A 383 (-3.5A)
 0.57A 5hfjA-3lduA:
2.4		 5hfjA-3lduA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpn TRANSPORTER

(Aquifex
aeolicus) 		PF00209
(SNF) 		5 ALA A 247
ASP A 234
GLY A  40
THR A 232
GLU A  37
 None
 1.16A 5hfjA-3mpnA:
undetectable		 5hfjA-3mpnA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oga NUCLEOSIDE
TRIPHOSPHATASE NUDI

(Salmonella
enterica) 		PF00293
(NUDIX) 		5 ALA A  34
PRO A   9
GLY A  38
THR A   5
GLU A  57
 None
 1.27A 5hfjA-3ogaA:
undetectable		 5hfjA-3ogaA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p9n POSSIBLE
METHYLTRANSFERASE
(METHYLASE)

(Mycobacterium
tuberculosis) 		PF03602
(Cons_hypoth95) 		5 ASP A 119
PRO A 121
GLY A  53
GLU A  73
SER A  74
 None
 0.78A 5hfjA-3p9nA:
3.2		 5hfjA-3p9nA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Homo sapiens) 		PF00145
(DNA_methylase)
PF01426
(BAH)
PF02008
(zf-CXXC) 		5 ASP A1190
PRO A1225
PHE A1145
GLY A1147
GLU A1168
 SAH  A1601 ( 4.7A)
SAH  A1601 (-4.2A)
SAH  A1601 (-4.4A)
SAH  A1601 (-3.5A)
SAH  A1601 (-3.0A)
 0.55A 5hfjA-3ptaA:
5.5		 5hfjA-3ptaA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tm5 CRYSTAL STRUCTURE OF
TRM14

(Pyrococcus
furiosus) 		PF01170
(UPF0020)
PF02926
(THUMP) 		6 ASP A 276
ALA A 277
PRO A 295
GLY A 227
THR A 230
GLU A 248
 SFG  A 401 (-3.4A)
SFG  A 401 (-3.1A)
SFG  A 401 ( 4.4A)
SFG  A 401 ( 3.7A)
SFG  A 401 (-3.3A)
SFG  A 401 (-2.6A)
 0.58A 5hfjA-3tm5A:
3.5		 5hfjA-3tm5A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tma METHYLTRANSFERASE

(Thermus
thermophilus) 		PF01170
(UPF0020)
PF02926
(THUMP) 		6 ASP A 243
ALA A 244
PRO A 262
PHE A 192
GLY A 194
THR A 197
 None
 0.73A 5hfjA-3tmaA:
3.4		 5hfjA-3tmaA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8v RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L

(Escherichia
coli) 		PF01170
(UPF0020)
PF02926
(THUMP)
PF10672
(Methyltrans_SAM) 		5 ASP A 290
PRO A 311
GLY A 199
THR A 202
SER A 263
 SAM  A 801 (-3.0A)
SAM  A 801 ( 4.1A)
SAM  A 801 (-3.2A)
SAM  A 801 (-4.1A)
SAM  A 801 (-3.5A)
 0.73A 5hfjA-3v8vA:
2.6		 5hfjA-3v8vA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsv XYLOSIDASE

(Thermoanaerobacterium
saccharolyticum) 		PF13229
(Beta_helix) 		5 ALA A 531
ASP A 552
PHE A 533
GLY A 482
GLU A 537
 None
 1.19A 5hfjA-3vsvA:
undetectable		 5hfjA-3vsvA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vyw MNMC2

(Aquifex
aeolicus) 		PF05430
(Methyltransf_30) 		5 ALA A 175
ASP A 193
GLY A 106
GLU A 133
GLU A 135
 SAM  A 501 (-3.8A)
SAM  A 501 (-3.8A)
SAM  A 501 (-3.3A)
SAM  A 501 (-2.3A)
None
 1.03A 5hfjA-3vywA:
5.2		 5hfjA-3vywA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vyw MNMC2

(Aquifex
aeolicus) 		PF05430
(Methyltransf_30) 		5 ASP A 174
ALA A 175
ASP A 193
GLY A 106
GLU A 133
 SAM  A 501 (-3.4A)
SAM  A 501 (-3.8A)
SAM  A 501 (-3.8A)
SAM  A 501 (-3.3A)
SAM  A 501 (-2.3A)
 0.73A 5hfjA-3vywA:
5.2		 5hfjA-3vywA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zif HEXON PROTEIN

(Bovine
mastadenovirus
B) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		5 PRO A 288
GLY A 217
THR A 213
SER A 123
TYR A 121
 None
 1.13A 5hfjA-3zifA:
undetectable		 5hfjA-3zifA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b4d FERREDOXIN-NADP
REDUCTASE

(Xanthomonas
citri) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		5 ASP A 211
ALA A 213
GLY A 248
THR A 246
TYR A 250
 None
 1.08A 5hfjA-4b4dA:
2.9		 5hfjA-4b4dA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7m TIR
DOMAIN-CONTAINING
PROTEIN

(Brucella
melitensis) 		PF13676
(TIR_2) 		5 ASP A 120
ALA A 119
ASP A 151
PHE A 149
THR A 154
 None
 1.07A 5hfjA-4c7mA:
undetectable		 5hfjA-4c7mA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cza NA+/H+ ANTIPORTER,
PUTATIVE

(Pyrococcus
abyssi) 		PF00999
(Na_H_Exchanger) 		5 ASP A 159
ALA A 128
PRO A 361
GLU A 154
SER A 155
 TL  A1423 (-2.1A)
None
None
None
TL  A1423 (-2.1A)
 1.35A 5hfjA-4czaA:
undetectable		 5hfjA-4czaA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dkj CYTOSINE-SPECIFIC
METHYLTRANSFERASE

(Mycoplasma
penetrans) 		PF00145
(DNA_methylase) 		5 ASP A 113
PRO A 134
PHE A  17
GLY A  19
GLU A  45
 SAH  A 501 (-3.7A)
SAH  A 501 ( 4.4A)
SAH  A 501 (-4.8A)
SAH  A 501 (-3.4A)
SAH  A 501 (-3.0A)
 0.60A 5hfjA-4dkjA:
undetectable		 5hfjA-4dkjA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dnx SULFATE
ADENYLYLTRANSFERASE

(Allochromatium
vinosum) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		5 ASP A 316
ALA A 317
PRO A 274
GLY A 137
THR A 132
 None
 1.24A 5hfjA-4dnxA:
undetectable		 5hfjA-4dnxA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hl6 UNCHARACTERIZED
PROTEIN YFDE

(Escherichia
coli) 		PF02515
(CoA_transf_3) 		5 ASP A 201
ASP A 173
GLY A  24
SER A 127
GLU A  99
 None
 0.91A 5hfjA-4hl6A:
undetectable		 5hfjA-4hl6A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwv PECTATE LYASE/AMB
ALLERGEN

(Acidovorax
citrulli) 		PF00544
(Pec_lyase_C) 		5 ALA A  27
ASP A 189
PRO A 500
GLY A 495
THR A 215
 None
 1.38A 5hfjA-4hwvA:
undetectable		 5hfjA-4hwvA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4opw UNCHARACTERIZED
PROTEIN

(Parabacteroides
merdae) 		PF10988
(DUF2807) 		5 ASP A  23
ALA A  91
PRO A  73
GLY A  27
THR A  97
 None
 1.39A 5hfjA-4opwA:
undetectable		 5hfjA-4opwA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3o MGS-MT1

(unidentified) 		PF07859
(Abhydrolase_3) 		5 ASP A 241
ASP A 226
PHE A 292
GLY A 231
TYR A 235
 None
 1.23A 5hfjA-4q3oA:
undetectable		 5hfjA-4q3oA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u7t DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A

(Homo sapiens) 		PF00145
(DNA_methylase) 		6 ASP A 686
PRO A 709
PHE A 640
GLY A 642
THR A 645
GLU A 664
 SAH  A1004 (-3.0A)
SAH  A1004 ( 3.9A)
SAH  A1004 (-4.6A)
SAH  A1004 (-3.3A)
SAH  A1004 (-3.3A)
SAH  A1004 (-3.0A)
 0.60A 5hfjA-4u7tA:
undetectable		 5hfjA-4u7tA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uip REPEBODY (RAC1)

(Listeria
monocytogenes;
Eptatretus
burgeri;
synthetic
construct) 		PF11921
(DUF3439)
PF12354
(Internalin_N)
PF13855
(LRR_8) 		5 ASP B 140
GLY B  73
SER B 118
GLU B 119
TYR B  95
 None
 1.31A 5hfjA-4uipB:
undetectable		 5hfjA-4uipB:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzs BETA-GALACTOSIDASE

(Bifidobacterium
bifidum) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		5 ASP A 353
ALA A 352
ASP A 456
GLY A 309
GLU A 314
 None
 1.15A 5hfjA-4uzsA:
undetectable		 5hfjA-4uzsA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v2x ENDO-BETA-1,4-GLUCAN
ASE (CELLULASE B)

(Bacillus
halodurans) 		PF00150
(Cellulase)
PF03442
(CBM_X2) 		6 ALA A 476
PHE A 478
GLY A 480
THR A 436
GLU A 545
TYR A 457
 None
 1.45A 5hfjA-4v2xA:
undetectable		 5hfjA-4v2xA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wxx DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Homo sapiens) 		PF00145
(DNA_methylase)
PF01426
(BAH)
PF02008
(zf-CXXC)
PF12047
(DNMT1-RFD) 		5 ASP A1190
PRO A1225
PHE A1145
GLY A1147
GLU A1168
 SAH  A1706 (-3.3A)
SAH  A1706 ( 4.7A)
SAH  A1706 (-4.8A)
SAH  A1706 (-3.2A)
SAH  A1706 (-2.8A)
 0.57A 5hfjA-4wxxA:
5.9		 5hfjA-4wxxA:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xqk LLABIII

(Lactococcus
lactis) 		PF00271
(Helicase_C)
PF02384
(N6_Mtase)
PF04851
(ResIII)
PF13156
(Mrr_cat_2) 		6 ASP A 981
PRO A1020
PHE A 904
GLY A 906
THR A 909
GLU A 944
 None
 0.58A 5hfjA-4xqkA:
undetectable		 5hfjA-4xqkA:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zcf RESTRICTION
ENDONUCLEASE
ECOP15I,
MODIFICATION SUBUNIT

(Escherichia
coli) 		PF01555
(N6_N4_Mtase) 		5 ASP A 101
ASP A 123
PHE A 441
GLY A 443
THR A 446
 None
 0.65A 5hfjA-4zcfA:
18.8		 5hfjA-4zcfA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zcf RESTRICTION
ENDONUCLEASE
ECOP15I,
MODIFICATION SUBUNIT

(Escherichia
coli) 		PF01555
(N6_N4_Mtase) 		5 ASP A 123
PRO A 125
PHE A 441
GLY A 443
THR A 446
 None
 0.61A 5hfjA-4zcfA:
18.8		 5hfjA-4zcfA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zdl O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE

(Homo sapiens) 		PF05889
(SepSecS) 		5 ASP A 283
PRO A 289
GLY A 292
THR A 144
SER A 317
 None
None
None
PLR  A1001 (-3.6A)
None
 1.28A 5hfjA-4zdlA:
3.2		 5hfjA-4zdlA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5afe ENDOGLUCANASE CEL5A

([Eubacterium]
cellulosolvens) 		no annotation 5 PRO A 692
PHE A 599
GLY A 696
THR A 698
GLU A 694
 None
 1.33A 5hfjA-5afeA:
undetectable		 5hfjA-5afeA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ah0 LIPASE

(Pelosinus
fermentans) 		no annotation 5 ALA A 194
ASP A 214
PHE A 215
GLY A  64
THR A  62
 None
 1.25A 5hfjA-5ah0A:
undetectable		 5hfjA-5ah0A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e72 N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE

(Thermococcus
kodakarensis) 		PF01170
(UPF0020)
PF02926
(THUMP) 		6 ASP A 235
ALA A 236
ASP A 254
PRO A 256
PHE A 187
GLY A 189
 SAM  A 400 (-3.4A)
SAM  A 400 (-3.5A)
None
SAM  A 400 (-4.2A)
SAM  A 400 (-4.7A)
SAM  A 400 (-3.3A)
 0.70A 5hfjA-5e72A:
3.0		 5hfjA-5e72A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ffj ENDONUCLEASE AND
METHYLASE LLAGI

(Lactococcus
lactis) 		PF00271
(Helicase_C)
PF02384
(N6_Mtase)
PF04851
(ResIII) 		6 ASP A 981
PRO A1020
PHE A 904
GLY A 906
THR A 909
GLU A 944
 None
 0.77A 5hfjA-5ffjA:
2.0		 5hfjA-5ffjA:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gut DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus musculus) 		PF00145
(DNA_methylase)
PF01426
(BAH) 		5 ASP A1193
PRO A1228
PHE A1148
GLY A1150
GLU A1171
 SAH  A1701 (-3.7A)
SAH  A1701 ( 4.5A)
SAH  A1701 (-4.8A)
SAH  A1701 (-3.5A)
SAH  A1701 (-2.7A)
 0.60A 5hfjA-5gutA:
2.2		 5hfjA-5gutA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h5j FERREDOXIN--NADP
REDUCTASE

(Zea mays) 		PF00175
(NAD_binding_1) 		5 ASP A 164
ALA A 167
PHE A 198
THR A  99
GLU A 162
 None
 1.31A 5hfjA-5h5jA:
2.5		 5hfjA-5h5jA:
21.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hfj ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA)

(Helicobacter
pylori) 		PF01555
(N6_N4_Mtase) 		12 ASP A   8
ALA A   9
ASP A  29
PRO A  31
LYS A 167
PHE A 195
GLY A 197
THR A 200
GLU A 216
SER A 217
GLU A 218
TYR A 221
 SAM  A 301 (-3.4A)
SAM  A 301 (-3.2A)
SAM  A 301 (-3.2A)
SAM  A 301 ( 4.0A)
SAM  A 301 (-4.1A)
SAM  A 301 (-4.6A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.6A)
SAM  A 301 (-3.1A)
SAM  A 301 (-2.8A)
None
SAM  A 301 (-4.2A)
 0.01A 5hfjA-5hfjA:
39.6		 5hfjA-5hfjA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hfj ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA)

(Helicobacter
pylori) 		PF01555
(N6_N4_Mtase) 		7 ASP A  29
PRO A  31
GLY A 197
THR A 201
GLU A 216
SER A 217
GLU A 218
 SAM  A 301 (-3.2A)
SAM  A 301 ( 4.0A)
SAM  A 301 (-3.4A)
None
SAM  A 301 (-3.1A)
SAM  A 301 (-2.8A)
None
 1.38A 5hfjA-5hfjA:
39.6		 5hfjA-5hfjA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hr4 MMEI

(Methylophilus
methylotrophus) 		no annotation 5 ALA C 461
PRO C 483
GLY C 365
GLU C 413
GLU C 415
 SFG  C1002 (-3.8A)
SFG  C1002 (-4.1A)
SFG  C1002 (-3.4A)
SFG  C1002 (-2.8A)
None
 0.53A 5hfjA-5hr4C:
undetectable		 5hfjA-5hr4C:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijz NADP-SPECIFIC
GLUTAMATE
DEHYDROGENASE

(Corynebacterium
glutamicum) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 ALA A 166
GLY A 204
THR A 201
GLU A 382
SER A 379
 AKG  A 502 (-3.3A)
None
None
None
AKG  A 502 (-2.5A)
 1.22A 5hfjA-5ijzA:
undetectable		 5hfjA-5ijzA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5il0 METTL3

(Homo sapiens) 		PF05063
(MT-A70) 		5 ASP A 377
ASP A 395
PRO A 397
PHE A 534
GLY A 535
 None
 0.92A 5hfjA-5il0A:
13.6		 5hfjA-5il0A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iy6 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPB
SUBUNIT

(Homo sapiens) 		PF04851
(ResIII)
PF16203
(ERCC3_RAD25_C) 		5 ALA V 562
GLY V 630
SER V 627
GLU V 669
TYR V 672
 None
 1.32A 5hfjA-5iy6V:
2.1		 5hfjA-5iy6V:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k0u CAPSID PROTEIN VP2

(Rhinovirus C) 		PF00073
(Rhv) 		5 ASP C  84
ALA C  85
ASP C  61
GLY C 105
TYR C 208
 None
 1.36A 5hfjA-5k0uC:
undetectable		 5hfjA-5k0uC:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdj F5/8 TYPE C DOMAIN
PROTEIN

(Clostridium
perfringens) 		no annotation 5 ASP B 871
ALA B 868
LYS B 514
PHE B 848
GLU B 850
 None
 1.27A 5hfjA-5kdjB:
undetectable		 5hfjA-5kdjB:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kds F5/8 TYPE C DOMAIN
PROTEIN

(Clostridium
perfringens) 		PF13402
(Peptidase_M60) 		5 ASP A 871
ALA A 868
LYS A 514
PHE A 848
GLU A 850
 None
 1.25A 5hfjA-5kdsA:
undetectable		 5hfjA-5kdsA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nyj ANBU

(Hyphomicrobium
sp. MC1) 		PF00227
(Proteasome) 		5 ALA A   3
PHE A 181
GLY A 156
GLU A 152
TYR A 155
 None
 1.32A 5hfjA-5nyjA:
undetectable		 5hfjA-5nyjA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o36 JAPANESE
ENCEPHALITIS VIRUS
NON-STRUCTURAL
PROTEIN 1'
(NS1'),JAPANESE
ENCEPHALITIS VIRUS
NON-STRUCTURAL
PROTEIN 1' (NS1')

(Japanese
encephalitis
virus) 		no annotation 5 ASP A 197
PHE A 217
GLY A 272
SER A 199
GLU A 219
 None
 1.22A 5hfjA-5o36A:
undetectable		 5hfjA-5o36A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tey N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT

(Homo sapiens) 		PF05063
(MT-A70) 		5 ASP A 377
ASP A 395
PRO A 397
PHE A 534
GLY A 535
 SAH  A 601 (-3.2A)
SAH  A 601 (-3.8A)
SAH  A 601 (-4.3A)
SAH  A 601 (-4.7A)
SAH  A 601 ( 4.6A)
 0.88A 5hfjA-5teyA:
13.7		 5hfjA-5teyA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w11 GLUCANASE

(Thermothelomyces
thermophila) 		no annotation 5 ASP A 251
ALA A 254
PRO A 259
SER A 249
TYR A 248
 None
None
None
None
CTR  A 505 ( 4.4A)
 1.26A 5hfjA-5w11A:
undetectable		 5hfjA-5w11A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wt3 TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A

(Pyrococcus
abyssi) 		no annotation 5 ASP A 243
PRO A 262
PHE A 191
GLY A 193
GLU A 213
 MTA  A 401 (-3.3A)
G  C  37 ( 4.1A)
MTA  A 401 (-4.4A)
MTA  A 401 (-3.6A)
MTA  A 401 (-3.5A)
 0.63A 5hfjA-5wt3A:
2.9		 5hfjA-5wt3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wug BETA-GLUCOSIDASE

(Paenibacillus
barengoltzii) 		no annotation 5 ASP A 683
ALA A 684
ASP A 171
GLY A 272
GLU A 275
 None
 1.38A 5hfjA-5wugA:
undetectable		 5hfjA-5wugA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xa1 INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1

(Mus musculus) 		PF01365
(RYDR_ITPR)
PF02815
(MIR)
PF08709
(Ins145_P3_rec) 		5 ALA A  75
ASP A  97
LYS A 100
PHE A  72
TYR A  66
 None
 1.34A 5hfjA-5xa1A:
undetectable		 5hfjA-5xa1A:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6q ALDEHYDE OXIDASE
MEDIUM SUBUNIT

(Methylobacillus
sp. KY4400) 		no annotation 5 ASP B  62
GLY B  69
THR B 107
SER B  67
GLU B 218
 None
None
FAD  B 401 (-3.0A)
None
None
 1.35A 5hfjA-5y6qB:
undetectable		 5hfjA-5y6qB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yz0 SERINE/THREONINE-PRO
TEIN KINASE ATR

(Homo sapiens) 		no annotation 5 ALA A2043
GLY A2079
THR A2276
SER A2075
TYR A2078
 None
 1.36A 5hfjA-5yz0A:
undetectable		 5hfjA-5yz0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6brr DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A

(Homo sapiens) 		no annotation 6 ASP A 686
PRO A 709
PHE A 640
GLY A 642
THR A 645
GLU A 664
 SAH  A1001 (-3.0A)
SAH  A1001 (-3.7A)
SAH  A1001 (-4.4A)
SAH  A1001 (-3.4A)
SAH  A1001 (-3.5A)
SAH  A1001 (-2.7A)
 0.48A 5hfjA-6brrA:
undetectable		 5hfjA-6brrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eo5 PPBBE-LIKE 1 D396N

(Physcomitrella
patens) 		no annotation 5 ALA A  69
ASP A 122
PRO A  78
GLY A 120
SER A 117
 None
None
None
None
FAD  A 601 (-2.6A)
 1.25A 5hfjA-6eo5A:
undetectable		 5hfjA-6eo5A:
undetectable