SIMILAR PATTERNS OF AMINO ACIDS FOR 5HES_B_032B401_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l8k T-CELL
PROTEIN-TYROSINE
PHOSPHATASE

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 CYH A  94
PHE A  97
ILE A 115
GLY A  88
 None
 1.09A 5hesB-1l8kA:
0.0		 5hesB-1l8kA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ot5 KEXIN

(Saccharomyces
cerevisiae) 		PF00082
(Peptidase_S8)
PF01483
(P_proprotein) 		4 CYH A 190
PHE A 189
ILE A 221
GLY A 242
 None
 1.28A 5hesB-1ot5A:
0.0		 5hesB-1ot5A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ttu LIN-12 AND GLP-1
TRANSCRIPTIONAL
REGULATOR

(Caenorhabditis
elegans) 		PF01833
(TIG)
PF09270
(BTD)
PF09271
(LAG1-DNAbind) 		4 CYH A 562
PHE A 548
ILE A 219
GLY A 356
 None
 1.39A 5hesB-1ttuA:
0.0		 5hesB-1ttuA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ttu LIN-12 AND GLP-1
TRANSCRIPTIONAL
REGULATOR

(Caenorhabditis
elegans) 		PF01833
(TIG)
PF09270
(BTD)
PF09271
(LAG1-DNAbind) 		4 CYH A 562
PHE A 548
ILE A 242
GLY A 356
 None
 1.26A 5hesB-1ttuA:
0.0		 5hesB-1ttuA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2do8 UPF0301 PROTEIN
HD_1794

([Haemophilus]
ducreyi) 		PF02622
(DUF179) 		4 CYH A 128
PHE A  84
ILE A  40
GLY A  76
 None
 1.24A 5hesB-2do8A:
0.0		 5hesB-2do8A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fvm DIHYDROPYRIMIDINASE

(Lachancea
kluyveri) 		PF01979
(Amidohydro_1) 		4 CYH A 526
PHE A 524
ILE A 354
GLY A 433
 None
 1.36A 5hesB-2fvmA:
0.0		 5hesB-2fvmA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fyw CONSERVED
HYPOTHETICAL PROTEIN

(Streptococcus
pneumoniae) 		PF01784
(NIF3) 		4 CYH A 114
PHE A 113
ILE A 134
GLY A 108
 None
 1.22A 5hesB-2fywA:
0.0		 5hesB-2fywA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqf HYPOTHETICAL PROTEIN
HI0933

(Haemophilus
influenzae) 		PF03486
(HI0933_like) 		4 CYH A  51
PHE A 103
ILE A  84
GLY A 381
 None
None
None
FAD  A 403 (-3.0A)
 0.85A 5hesB-2gqfA:
undetectable		 5hesB-2gqfA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h31 MULTIFUNCTIONAL
PROTEIN ADE2

(Homo sapiens) 		PF00731
(AIRC)
PF01259
(SAICAR_synt) 		4 CYH A 288
PHE A 291
ILE A 348
GLY A 382
 None
 1.42A 5hesB-2h31A:
3.9		 5hesB-2h31A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0z NAD(FAD)-UTILIZING
DEHYDROGENASES

(Bacillus cereus) 		PF03486
(HI0933_like) 		4 CYH A  49
PHE A 103
ILE A  83
GLY A 398
 None
None
None
FAD  A 501 ( 3.3A)
 0.98A 5hesB-2i0zA:
0.0		 5hesB-2i0zA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ic7 MALTOSE
TRANSACETYLASE

(Geobacillus
kaustophilus) 		PF00132
(Hexapep)
PF12464
(Mac)
PF14602
(Hexapep_2) 		4 CYH A 101
PHE A  82
ILE A  89
GLY A 104
 None
 1.39A 5hesB-2ic7A:
undetectable		 5hesB-2ic7A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2in3 HYPOTHETICAL PROTEIN

(Nitrosomonas
europaea) 		PF01323
(DSBA) 		4 CYH A  19
PHE A  22
ILE A 172
GLY A 192
 None
None
None
GOL  A 220 (-3.3A)
 1.31A 5hesB-2in3A:
undetectable		 5hesB-2in3A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p82 CYSTEINE PROTEASE
ATG4A

(Homo sapiens) 		PF03416
(Peptidase_C54) 		4 CYH A 247
PHE A 244
ILE A 226
GLY A 255
 None
 1.37A 5hesB-2p82A:
0.1		 5hesB-2p82A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3djd FRUCTOSYL AMINE:
OXYGEN
OXIDOREDUCTASE

(Aspergillus
fumigatus) 		PF01266
(DAO) 		4 CYH A 216
PHE A 214
ILE A 393
GLY A 374
 None
 1.40A 5hesB-3djdA:
undetectable		 5hesB-3djdA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dsm UNCHARACTERIZED
PROTEIN BACUNI_02894

(Bacteroides
uniformis) 		no annotation 4 CYH A 332
PHE A  19
ILE A  80
GLY A  70
 None
 1.49A 5hesB-3dsmA:
undetectable		 5hesB-3dsmA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ele AMINO TRANSFERASE

([Eubacterium]
rectale) 		PF00155
(Aminotran_1_2) 		4 CYH A 114
PHE A 115
ILE A 177
GLY A 174
 None
 1.47A 5hesB-3eleA:
0.5		 5hesB-3eleA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g0t PUTATIVE
AMINOTRANSFERASE

(Porphyromonas
gingivalis) 		PF00155
(Aminotran_1_2) 		4 CYH A 395
PHE A 389
ILE A  10
GLY A 393
 None
 1.38A 5hesB-3g0tA:
undetectable		 5hesB-3g0tA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gmi UPF0348 PROTEIN
MJ0951

(Methanocaldococcus
jannaschii) 		PF05636
(HIGH_NTase1)
PF16581
(HIGH_NTase1_ass) 		4 CYH A  54
PHE A  79
ILE A  43
GLY A  77
 None
 1.44A 5hesB-3gmiA:
undetectable		 5hesB-3gmiA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4u MAJOR CAPSID PROTEIN

(Bordetella
virus BPP1) 		no annotation 4 CYH A 317
PHE A 276
ILE A 290
GLY A 314
 None
 1.47A 5hesB-3j4uA:
undetectable		 5hesB-3j4uA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kst ENDO-1,4-BETA-XYLANA
SE

(Bacteroides
thetaiotaomicron) 		PF04616
(Glyco_hydro_43) 		4 CYH A  76
PHE A  77
ILE A 289
GLY A  64
 None
 1.26A 5hesB-3kstA:
undetectable		 5hesB-3kstA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m9l HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Pseudomonas
protegens) 		PF13419
(HAD_2) 		4 CYH A 159
PHE A 155
ILE A  91
GLY A 151
 None
GOL  A 206 (-3.6A)
None
None
 1.32A 5hesB-3m9lA:
undetectable		 5hesB-3m9lA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rg1 CD180 MOLECULE

(Bos taurus) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		4 CYH A 455
PHE A 429
ILE A 502
GLY A 478
 None
 1.43A 5hesB-3rg1A:
undetectable		 5hesB-3rg1A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdn MONOAMINE OXIDASE N

(Aspergillus
niger) 		PF01593
(Amino_oxidase) 		4 CYH A 277
PHE A 275
ILE A  43
GLY A  46
 None
None
None
FAD  A1487 (-3.5A)
 1.48A 5hesB-3zdnA:
undetectable		 5hesB-3zdnA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4amf PHOX

(Pseudomonas
fluorescens) 		PF05787
(DUF839) 		4 CYH A 513
PHE A 524
ILE A 583
GLY A  12
 None
 1.46A 5hesB-4amfA:
undetectable		 5hesB-4amfA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cnk L-AMINO ACID OXIDASE

(Streptococcus
cristatus) 		PF03486
(HI0933_like) 		4 CYH A  50
PHE A 104
ILE A  84
GLY A 372
 None
None
None
FAD  A1392 (-3.2A)
 1.03A 5hesB-4cnkA:
undetectable		 5hesB-4cnkA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yx8 DSBA-LIKE PROTEIN

(Proteus
mirabilis) 		PF13462
(Thioredoxin_4) 		4 CYH A  87
PHE A  90
ILE A 189
GLY A 204
 None
 1.29A 5hesB-4yx8A:
undetectable		 5hesB-4yx8A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp9 PUTATIVE
METHYLTRANSFERASE
PROTEIN

(Bacteroides
fragilis) 		PF13489
(Methyltransf_23) 		4 CYH A  93
PHE A  63
ILE A  57
GLY A  90
 SAH  A 303 ( 4.2A)
None
None
SAH  A 303 ( 3.7A)
 1.44A 5hesB-5bp9A:
undetectable		 5hesB-5bp9A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c0n FAB CA33 HEAVY CHAIN
FAB CA33 LIGHT CHAIN

(Oryctolagus
cuniculus) 		no annotation 4 CYH L  90
PHE L 103
ILE H  49
GLY H 106
 None
 1.35A 5hesB-5c0nL:
undetectable		 5hesB-5c0nL:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ipx ORF49 PROTEIN

(Human
gammaherpesvirus
8) 		PF04793
(Herpes_BBRF1) 		4 CYH A 211
PHE A 212
ILE A  95
GLY A 120
 None
 1.15A 5hesB-5ipxA:
undetectable		 5hesB-5ipxA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ji5 BUPHA.10154.A.B1

(Paraburkholderia
phymatum) 		PF00850
(Hist_deacetyl) 		4 CYH A 283
PHE A 117
ILE A 268
GLY A 242
 None
 1.34A 5hesB-5ji5A:
undetectable		 5hesB-5ji5A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jkj ESTERASE E22

(uncultured
bacterium) 		PF00561
(Abhydrolase_1) 		4 CYH A 310
PHE A 313
ILE A 199
GLY A 177
 None
 1.25A 5hesB-5jkjA:
undetectable		 5hesB-5jkjA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k7m N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14

(Homo sapiens) 		PF05063
(MT-A70) 		4 CYH B 288
PHE B 232
ILE B 221
GLY B 291
 None
 1.40A 5hesB-5k7mB:
undetectable		 5hesB-5k7mB:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n8n EVPB FAMILY TYPE VI
SECRETION PROTEIN

(Pseudomonas
aeruginosa) 		no annotation 4 CYH B 300
PHE B 294
ILE B 116
GLY B 161
 None
 1.39A 5hesB-5n8nB:
undetectable		 5hesB-5n8nB:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x68 KYNURENINE
3-MONOOXYGENASE

(Homo sapiens) 		no annotation 4 CYH A  25
PHE A  26
ILE A  75
GLY A  70
 None
 1.14A 5hesB-5x68A:
undetectable		 5hesB-5x68A:
14.80