SIMILAR PATTERNS OF AMINO ACIDS FOR 5HES_B_032B401_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gng GLYCOGEN SYNTHASE
KINASE-3 BETA

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  70
ALA A  83
LYS A  85
TYR A 134
CYH A 199
PHE A 201
 None
 1.01A 5hesB-1gngA:
20.1		 5hesB-1gngA:
26.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jxi PHOSPHOMETHYLPYRIMID
INE KINASE

(Salmonella
enterica) 		PF08543
(Phos_pyr_kin) 		6 VAL A 103
ALA A 220
LYS A  77
ALA A 236
ASP A 187
GLY A  19
 None
None
None
None
None
HMH  A2001 ( 3.8A)
 1.44A 5hesB-1jxiA:
undetectable		 5hesB-1jxiA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k2p TYROSINE-PROTEIN
KINASE BTK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 416
ALA A 428
LYS A 430
ILE A 472
THR A 474
TYR A 476
PHE A 540
GLY A 541
 None
 0.78A 5hesB-1k2pA:
21.2		 5hesB-1k2pA:
29.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 VAL A 209
ALA A 220
LYS A 222
ILE A 264
THR A 266
ASP A 276
GLY A 334
 None
 0.88A 5hesB-1k9aA:
21.7		 5hesB-1k9aA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 VAL A 209
ALA A 220
LYS A 222
ILE A 264
THR A 266
TYR A 268
ASP A 276
PHE A 333
 None
 0.83A 5hesB-1k9aA:
21.7		 5hesB-1k9aA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 GLY A 268
ALA A 288
LYS A 290
ILE A 332
THR A 334
ASP A 344
 P16  A   2 ( 4.3A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
None
 1.00A 5hesB-1opkA:
27.3		 5hesB-1opkA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 GLY A 268
VAL A 275
ALA A 288
LYS A 290
ILE A 332
THR A 334
 P16  A   2 ( 4.3A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
 0.67A 5hesB-1opkA:
27.3		 5hesB-1opkA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 GLY A 269
VAL A 275
ALA A 288
LYS A 290
ILE A 332
THR A 334
 None
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
 0.76A 5hesB-1opkA:
27.3		 5hesB-1opkA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 603
ALA A 621
LYS A 623
THR A 670
TYR A 672
CYH A 809
 STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.2A)
STI  A   3 ( 4.0A)
STI  A   3 (-4.5A)
 0.66A 5hesB-1t46A:
24.7		 5hesB-1t46A:
28.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  23
ALA A  36
LYS A  38
TYR A  86
ASP A  94
PHE A 149
 HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
HYM  A 400 (-4.7A)
None
None
 0.96A 5hesB-1zltA:
20.5		 5hesB-1zltA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL X  25
ALA X  37
LYS X  39
ILE X  80
THR X  82
ASP X  92
 STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
None
STU  X 902 (-4.1A)
None
 0.48A 5hesB-2dq7X:
26.1		 5hesB-2dq7X:
29.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 VAL A 281
ALA A 293
ILE A 336
THR A 338
ASP A 348
PHE A 405
GLY A 406
 H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 ( 4.5A)
H8H  A 534 (-3.1A)
None
None
None
 0.80A 5hesB-2h8hA:
27.1		 5hesB-2h8hA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 VAL A 281
ALA A 293
ILE A 336
THR A 338
TYR A 340
ASP A 348
PHE A 405
 H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 ( 4.5A)
H8H  A 534 (-3.1A)
H8H  A 534 (-4.3A)
None
None
 0.78A 5hesB-2h8hA:
27.1		 5hesB-2h8hA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 VAL A 281
ALA A 293
LYS A 295
ILE A 336
THR A 338
TYR A 340
PHE A 405
 H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
H8H  A 534 ( 4.5A)
H8H  A 534 (-3.1A)
H8H  A 534 (-4.3A)
None
 0.66A 5hesB-2h8hA:
27.1		 5hesB-2h8hA:
19.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hen EPHRIN TYPE-B
RECEPTOR 2

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 VAL A 643
ALA A 659
LYS A 661
ILE A 705
THR A 707
GLY A 774
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 (-2.7A)
None
ADP  A 400 (-4.7A)
None
 0.90A 5hesB-2henA:
27.0		 5hesB-2henA:
31.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 259
ALA A 271
LYS A 273
ILE A 314
THR A 316
ASP A 326
PHE A 383
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
None
None
 0.79A 5hesB-2hk5A:
25.8		 5hesB-2hk5A:
26.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 256
ALA A 269
LYS A 271
ILE A 313
THR A 315
ASP A 325
 GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.8A)
GIN  A 600 (-3.4A)
None
 0.56A 5hesB-2hz0A:
25.3		 5hesB-2hz0A:
32.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6l MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  34
ALA A  47
LYS A  49
ILE A 106
TYR A 110
GLY A 173
 None
 1.10A 5hesB-2i6lA:
21.7		 5hesB-2i6lA:
28.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 259
ALA A 271
LYS A 273
ILE A 314
THR A 316
TYR A 318
ASP A 326
 None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.4A)
1N8  A 501 ( 4.6A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.7A)
None
 0.67A 5hesB-2og8A:
26.0		 5hesB-2og8A:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 204
ALA A 215
LYS A 217
THR A 265
ASP A 275
GLY A 341
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
ADE  A 488 (-4.3A)
None
None
 0.88A 5hesB-2qluA:
24.6		 5hesB-2qluA:
29.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 204
ALA A 215
LYS A 217
THR A 265
ASP A 275
PHE A 340
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
ADE  A 488 (-4.3A)
None
None
 0.84A 5hesB-2qluA:
24.6		 5hesB-2qluA:
29.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uzz N-METHYL-L-TRYPTOPHA
N OXIDASE

(Escherichia
coli) 		PF01266
(DAO) 		6 GLY A 339
VAL A  13
ALA A  16
ILE A   7
ALA A 151
PHE A 168
 FAD  A1373 (-3.2A)
FAD  A1373 (-3.8A)
None
None
None
None
 1.48A 5hesB-2uzzA:
undetectable		 5hesB-2uzzA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 VAL A 635
ALA A 651
LYS A 653
ILE A 697
THR A 699
 Q9G  A1898 ( 4.7A)
Q9G  A1898 (-3.2A)
Q9G  A1898 (-4.8A)
Q9G  A1898 ( 4.6A)
Q9G  A1898 (-3.5A)
 0.32A 5hesB-2xyuA:
27.3		 5hesB-2xyuA:
29.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y35 LD22664P

(Drosophila
melanogaster) 		PF03159
(XRN_N) 		6 GLY A 453
ALA A  92
ILE A 290
ALA A  89
ASP A 182
GLY A 286
 None
 1.41A 5hesB-2y35A:
undetectable		 5hesB-2y35A:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2m PENICILLIN-BINDING
PROTEIN 2X

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase) 		6 GLY B 500
VAL B 503
ALA B 508
ILE B 348
THR B 511
ALA B 469
 None
 1.47A 5hesB-2z2mB:
undetectable		 5hesB-2z2mB:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2w WEE1-LIKE PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 313
ALA A 326
ILE A 374
TYR A 378
ASP A 386
GLY A 465
 770  A 901 ( 4.7A)
770  A 901 (-3.5A)
None
770  A 901 (-4.2A)
None
None
 0.98A 5hesB-2z2wA:
22.5		 5hesB-2z2wA:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 VAL A 261
ALA A 273
LYS A 275
ILE A 317
THR A 319
PHE A 386
 None
 0.69A 5hesB-2zv7A:
26.8		 5hesB-2zv7A:
25.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 209
ALA A 220
LYS A 222
ILE A 264
THR A 266
ASP A 276
GLY A 334
 None
 0.88A 5hesB-3d7uA:
21.8		 5hesB-3d7uA:
31.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 209
ALA A 220
LYS A 222
ILE A 264
THR A 266
TYR A 268
ASP A 276
PHE A 333
 None
 0.83A 5hesB-3d7uA:
21.8		 5hesB-3d7uA:
31.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fme DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  67
ALA A  80
LYS A  82
ILE A 127
ASP A 137
CYH A 196
 None
STU  A   1 (-3.4A)
STU  A   1 ( 4.2A)
None
STU  A   1 (-3.5A)
STU  A   1 ( 3.7A)
 0.84A 5hesB-3fmeA:
17.9		 5hesB-3fmeA:
26.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kex RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 704
LYS A 723
THR A 768
TYR A 770
ASP A 778
PHE A 834
 ANP  A   1 (-3.9A)
ANP  A   1 (-3.4A)
ANP  A   1 ( 4.8A)
ANP  A   1 (-4.3A)
None
None
 0.78A 5hesB-3kexA:
26.6		 5hesB-3kexA:
30.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		6 VAL A 649
ALA A 665
LYS A 667
ILE A 711
THR A 713
GLY A 780
 None
 1.08A 5hesB-3kulA:
26.8		 5hesB-3kulA:
30.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		6 VAL A 649
ALA A 665
LYS A 667
ILE A 711
THR A 713
PHE A 779
 None
 0.75A 5hesB-3kulA:
26.8		 5hesB-3kulA:
30.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 216
ALA A 227
LYS A 229
THR A 277
TYR A 279
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
LDN  A 600 (-4.0A)
LDN  A 600 (-4.7A)
 0.36A 5hesB-3my0A:
24.5		 5hesB-3my0A:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n9x PHOSPHOTRANSFERASE

(Plasmodium
berghei) 		PF00069
(Pkinase) 		6 VAL A  42
ALA A  55
LYS A  57
ILE A 107
ALA A 112
CYH A 171
 None
GOL  A 434 ( 4.1A)
GOL  A 433 (-3.2A)
None
GOL  A 434 (-3.9A)
GOL  A 433 ( 3.7A)
 0.59A 5hesB-3n9xA:
20.0		 5hesB-3n9xA:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nie MAP2 KINASE

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		6 VAL A  44
ALA A  57
LYS A  59
ILE A 109
ALA A 114
CYH A 173
 ANP  A 430 (-4.2A)
ANP  A 430 (-3.5A)
ANP  A 430 (-2.5A)
None
ANP  A 430 (-3.9A)
ANP  A 430 ( 3.8A)
 0.56A 5hesB-3nieA:
20.5		 5hesB-3nieA:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  96
ALA A 109
LYS A 111
TYR A 161
ALA A 162
PHE A 224
 JOZ  A 361 ( 4.7A)
JOZ  A 361 (-3.4A)
SO4  A   5 (-2.8A)
None
JOZ  A 361 (-3.8A)
None
 0.90A 5hesB-3nuuA:
22.7		 5hesB-3nuuA:
25.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 363
ALA A 373
LYS A 375
ILE A 419
THR A 421
PHE A 487
 SM5  A   1 (-4.0A)
SM5  A   1 (-3.6A)
SM5  A   1 (-3.5A)
SM5  A   1 ( 4.3A)
SM5  A   1 (-4.4A)
None
 0.78A 5hesB-3omvA:
26.1		 5hesB-3omvA:
30.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		8 VAL A 565
ALA A 576
LYS A 578
ILE A 623
THR A 625
TYR A 627
CYH A 693
GLY A 696
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
STU  A   1 (-4.1A)
STU  A   1 (-4.4A)
STU  A   1 (-3.5A)
None
 1.02A 5hesB-3ppzA:
29.4		 5hesB-3ppzA:
35.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		8 VAL A 565
ALA A 576
LYS A 578
ILE A 623
THR A 625
TYR A 627
CYH A 693
PHE A 695
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
STU  A   1 (-4.1A)
STU  A   1 (-4.4A)
STU  A   1 (-3.5A)
None
 0.87A 5hesB-3ppzA:
29.4		 5hesB-3ppzA:
35.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		6 VAL B 603
ALA B 616
LYS B 618
ILE B 884
ASP B 896
GLY B 955
 None
 1.15A 5hesB-3qd2B:
21.5		 5hesB-3qd2B:
25.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 431
ALA A 443
LYS A 445
ILE A 487
THR A 489
TYR A 491
 PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.6A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.9A)
 0.73A 5hesB-3sxsA:
26.4		 5hesB-3sxsA:
31.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 492
ALA A 512
LYS A 514
TYR A 563
ALA A 564
PHE A 642
GLY A 643
 07J  A   1 (-4.0A)
07J  A   1 (-3.5A)
07J  A   1 (-4.5A)
07J  A   1 (-4.7A)
07J  A   1 (-3.8A)
07J  A   1 ( 4.6A)
None
 0.82A 5hesB-3tt0A:
25.3		 5hesB-3tt0A:
28.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3uc3 SERINE/THREONINE-PRO
TEIN KINASE SRK2I

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		6 ALA A  49
ILE A  93
TYR A  97
ALA A  98
CYH A 160
GLY A 163
 None
None
None
None
CO  A 363 (-2.0A)
None
 1.38A 5hesB-3uc3A:
20.3		 5hesB-3uc3A:
30.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 633
ALA A 649
LYS A 651
ILE A 695
THR A 697
 None
 0.42A 5hesB-3zfxA:
27.7		 5hesB-3zfxA:
31.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4af3 AURORA KINASE B

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  91
ALA A 104
LYS A 106
TYR A 156
ALA A 157
GLY A 220
 VX6  A 500 ( 4.8A)
VX6  A 500 (-3.4A)
VX6  A 500 (-3.3A)
VX6  A 500 (-4.2A)
VX6  A 500 (-3.7A)
None
 0.99A 5hesB-4af3A:
20.2		 5hesB-4af3A:
26.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agu CYCLIN-DEPENDENT
KINASE-LIKE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  18
ALA A  31
LYS A  33
TYR A  82
CYH A 143
GLY A 146
 D15  A 500 (-4.6A)
D15  A 500 (-3.4A)
D15  A 500 ( 4.1A)
D15  A 500 (-4.8A)
D15  A 500 ( 4.0A)
None
 1.02A 5hesB-4aguA:
22.8		 5hesB-4aguA:
24.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 105
ALA A 121
LYS A 123
ILE A 167
THR A 169
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
None
30K  A1365 (-3.8A)
 0.27A 5hesB-4aw5A:
27.2		 5hesB-4aw5A:
31.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		6 VAL A 222
ALA A 233
LYS A 235
THR A 283
TYR A 285
ASP A 293
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
TAK  A1507 (-3.6A)
TAK  A1507 ( 4.6A)
None
 0.78A 5hesB-4c02A:
24.4		 5hesB-4c02A:
28.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE

(Candida
albicans) 		PF00069
(Pkinase) 		6 VAL A 254
ALA A 267
LYS A 269
TYR A 320
ALA A 321
PHE A 383
 None
 0.69A 5hesB-4c0tA:
21.9		 5hesB-4c0tA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 VAL A 671
ALA A 684
LYS A 686
TYR A 739
ALA A 740
PHE A 801
 AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
AGS  A1985 (-3.9A)
None
 0.81A 5hesB-4crsA:
20.8		 5hesB-4crsA:
29.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f99 CELL DIVISION CYCLE
7-RELATED PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  72
ALA A  88
LYS A  90
ILE A 132
TYR A 136
PHE A 197
 ADP  A 601 (-4.0A)
ADP  A 601 (-3.5A)
ADP  A 601 (-2.6A)
None
ADP  A 601 (-4.1A)
None
 0.92A 5hesB-4f99A:
19.7		 5hesB-4f99A:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 606
ALA A 619
LYS A 621
ILE A 885
PHE A 955
GLY A 956
 924  A1101 ( 4.8A)
924  A1101 (-3.5A)
None
924  A1101 ( 4.6A)
924  A1101 ( 4.4A)
None
 0.81A 5hesB-4g34A:
22.6		 5hesB-4g34A:
27.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3f NF-KAPPA-BETA-INDUCI
NG KINASE

(Mus musculus) 		PF00069
(Pkinase) 		6 VAL A 416
ALA A 429
LYS A 431
ILE A 469
CYH A 535
GLY A 538
 0WB  A 701 (-4.4A)
0WB  A 701 (-3.3A)
0WB  A 701 (-3.0A)
0WB  A 701 (-3.9A)
0WB  A 701 ( 3.7A)
None
 1.05A 5hesB-4g3fA:
22.3		 5hesB-4g3fA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gv1 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 VAL A 164
ALA A 177
LYS A 179
TYR A 229
ALA A 230
PHE A 293
 0XZ  A 501 (-4.5A)
0XZ  A 501 (-3.3A)
GOL  A 503 ( 2.8A)
0XZ  A 501 ( 4.9A)
0XZ  A 501 (-3.7A)
None
 0.80A 5hesB-4gv1A:
21.6		 5hesB-4gv1A:
24.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hzs ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14604
(SH3_9) 		7 VAL A 140
ALA A 156
LYS A 158
THR A 205
ALA A 208
ASP A 215
PHE A 271
 None
 0.75A 5hesB-4hzsA:
25.5		 5hesB-4hzsA:
33.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4id7 ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 140
ALA A 156
LYS A 158
THR A 205
ALA A 208
ASP A 215
PHE A 271
 1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
1G0  A 401 (-3.2A)
1G0  A 401 (-3.8A)
None
1G0  A 401 ( 4.8A)
 0.88A 5hesB-4id7A:
25.8		 5hesB-4id7A:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 414
ALA A 427
LYS A 429
ILE A 467
CYH A 533
GLY A 536
 T28  A 701 (-4.7A)
T28  A 701 (-3.0A)
T28  A 701 ( 3.8A)
None
T28  A 701 (-3.7A)
None
 1.27A 5hesB-4idtA:
22.0		 5hesB-4idtA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 414
ALA A 427
LYS A 429
ILE A 467
CYH A 533
PHE A 535
 T28  A 701 (-4.7A)
T28  A 701 (-3.0A)
T28  A 701 ( 3.8A)
None
T28  A 701 (-3.7A)
None
 0.99A 5hesB-4idtA:
22.0		 5hesB-4idtA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 VAL A 281
ALA A 293
ILE A 336
TYR A 340
ASP A 348
PHE A 405
 0J9  A 601 (-4.4A)
0J9  A 601 (-3.3A)
0J9  A 601 (-4.4A)
0J9  A 601 ( 4.7A)
None
None
 0.86A 5hesB-4k11A:
26.8		 5hesB-4k11A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 VAL A 281
ALA A 293
LYS A 295
ILE A 336
TYR A 340
PHE A 405
 0J9  A 601 (-4.4A)
0J9  A 601 (-3.3A)
0J9  A 601 ( 4.7A)
0J9  A 601 (-4.4A)
0J9  A 601 ( 4.7A)
None
 0.54A 5hesB-4k11A:
26.8		 5hesB-4k11A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 486
ALA A 506
LYS A 508
TYR A 557
ALA A 558
PHE A 636
 ACP  A 801 (-4.2A)
ACP  A 801 (-3.3A)
ACP  A 801 (-2.7A)
None
ACP  A 801 (-3.7A)
None
 0.94A 5hesB-4k33A:
25.9		 5hesB-4k33A:
29.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A  50
ALA A  61
LYS A  63
ALA A 107
CYH A 174
PHE A 176
 1UL  A 501 ( 4.9A)
1UL  A 501 (-3.1A)
None
1UL  A 501 (-3.6A)
1UL  A 501 (-3.6A)
None
 0.81A 5hesB-4l52A:
27.9		 5hesB-4l52A:
35.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		6 VAL A 281
ALA A 293
LYS A 295
ILE A 336
TYR A 340
ASP A 348
 VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 (-4.2A)
VGG  A 601 ( 4.0A)
None
 0.91A 5hesB-4lggA:
26.8		 5hesB-4lggA:
28.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL B  38
ALA B  51
LYS B  53
ILE B  97
TYR B 101
ASP B 109
PHE B 163
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
None
ADP  B 500 ( 4.7A)
None
None
 0.76A 5hesB-4o27B:
20.2		 5hesB-4o27B:
30.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL B  38
ALA B  51
LYS B  53
ILE B  97
TYR B 101
PHE B 163
GLY B 164
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
None
ADP  B 500 ( 4.7A)
None
None
 0.89A 5hesB-4o27B:
20.2		 5hesB-4o27B:
30.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  54
ALA A  67
LYS A  69
THR A 123
CYH A 190
PHE A 192
 None
SIN  A 401 ( 3.7A)
None
None
None
None
 0.76A 5hesB-4o38A:
19.0		 5hesB-4o38A:
25.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p2k EPHRIN TYPE-A
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		5 VAL A 627
ALA A 644
ILE A 690
THR A 692
TYR A 694
 None
 0.45A 5hesB-4p2kA:
23.8		 5hesB-4p2kA:
30.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q1q ADHESIN/INVASIN TIBA
AUTOTRANSPORTER

(Escherichia
coli) 		PF16168
(AIDA) 		6 GLY A 228
VAL A 206
ALA A 212
THR A 215
ALA A 249
GLY A 202
 None
 1.44A 5hesB-4q1qA:
undetectable		 5hesB-4q1qA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q1q ADHESIN/INVASIN TIBA
AUTOTRANSPORTER

(Escherichia
coli) 		PF16168
(AIDA) 		6 GLY A 228
VAL A 206
ALA A 212
THR A 215
ALA A 249
GLY A 221
 None
 1.45A 5hesB-4q1qA:
undetectable		 5hesB-4q1qA:
20.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		8 VAL A  22
ALA A  35
LYS A  37
ILE A  79
THR A  81
TYR A  83
ASP A  91
PHE A 148
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
None
None
 0.78A 5hesB-4ueuA:
26.7		 5hesB-4ueuA:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 6 VAL B 275
ALA B 288
LYS B 290
ILE B 332
THR B 334
ASP B 344
 1N1  B 601 ( 4.9A)
1N1  B 601 (-3.5A)
1N1  B 601 (-4.6A)
1N1  B 601 (-4.1A)
1N1  B 601 (-3.3A)
None
 0.65A 5hesB-4xeyB:
25.9		 5hesB-4xeyB:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 VAL A 416
ALA A 428
ILE A 472
THR A 474
TYR A 476
PHE A 540
 None
 0.76A 5hesB-4xi2A:
26.5		 5hesB-4xi2A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		7 VAL A 416
ALA A 428
LYS A 430
ILE A 472
THR A 474
TYR A 476
PHE A 540
 746  A 702 ( 4.3A)
746  A 702 (-2.4A)
746  A 702 (-3.7A)
None
746  A 702 (-3.7A)
746  A 702 (-4.4A)
None
 0.67A 5hesB-4y93A:
27.6		 5hesB-4y93A:
19.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 477
ALA A 488
LYS A 490
ILE A 537
THR A 539
TYR A 541
PHE A 607
 None
4CV  A 801 (-3.5A)
4CV  A 801 (-3.9A)
None
4CV  A 801 (-2.8A)
4CV  A 801 (-3.9A)
None
 0.83A 5hesB-4yffA:
25.4		 5hesB-4yffA:
31.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		6 VAL A  42
ALA A  55
LYS A  57
THR A 105
ASP A 115
GLY A 174
 ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
ADP  A 506 ( 4.6A)
None
None
 1.07A 5hesB-4ysjA:
23.8		 5hesB-4ysjA:
25.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 492
ALA A 512
LYS A 514
TYR A 563
ALA A 564
PHE A 642
GLY A 643
 38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
38O  A1769 (-4.2A)
38O  A1769 (-3.9A)
EDO  A1766 (-3.7A)
EDO  A1766 (-3.6A)
 0.66A 5hesB-5a46A:
25.9		 5hesB-5a46A:
30.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		6 ALA A 134
ILE A 130
THR A 131
TYR A 133
ALA A 150
GLY A  84
 None
 1.44A 5hesB-5ahkA:
undetectable		 5hesB-5ahkA:
19.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e8y TGF-BETA RECEPTOR
TYPE-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 258
ALA A 275
LYS A 277
THR A 325
CYH A 396
 STU  A 601 (-4.0A)
STU  A 601 (-3.1A)
STU  A 601 (-2.4A)
STU  A 601 ( 3.7A)
STU  A 601 (-3.2A)
 0.41A 5hesB-5e8yA:
20.3		 5hesB-5e8yA:
30.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		7 VAL A  70
ALA A  83
LYS A  85
TYR A 134
ALA A 135
ASP A 142
GLY A 198
 5RC  A4000 (-4.6A)
5RC  A4000 (-3.6A)
5RC  A4000 (-2.8A)
5RC  A4000 (-4.5A)
5RC  A4000 (-3.7A)
None
None
 1.19A 5hesB-5es1A:
22.5		 5hesB-5es1A:
27.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		6 VAL A  70
LYS A  85
TYR A 134
ALA A 135
ASP A 142
PHE A 197
 5RC  A4000 (-4.6A)
5RC  A4000 (-2.8A)
5RC  A4000 (-4.5A)
5RC  A4000 (-3.7A)
None
None
 1.07A 5hesB-5es1A:
22.5		 5hesB-5es1A:
27.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 911
ALA A 928
LYS A 930
TYR A 980
ASP A 988
PHE A1042
 5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
5U3  A1200 (-4.5A)
None
None
 0.99A 5hesB-5f1zA:
24.6		 5hesB-5f1zA:
29.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fbh EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR

(Homo sapiens) 		no annotation 6 GLY B  67
ALA B 168
TYR B 167
ALA B 144
ASP B  99
GLY B 219
 None
TCR  B 609 (-4.1A)
None
CL  B 605 ( 3.8A)
None
None
 1.35A 5hesB-5fbhB:
undetectable		 5hesB-5fbhB:
20.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fd2 SERINE/THREONINE-PRO
TEIN KINASE B-RAF

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 471
ALA A 481
LYS A 483
ILE A 527
THR A 529
PHE A 595
GLY A 596
 5XJ  A 801 (-4.6A)
5XJ  A 801 (-3.1A)
5XJ  A 801 (-3.8A)
5XJ  A 801 ( 4.0A)
5XJ  A 801 (-3.4A)
5XJ  A 801 (-3.7A)
5XJ  A 801 (-3.7A)
 0.32A 5hesB-5fd2A:
21.7		 5hesB-5fd2A:
31.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 607
ALA A 625
LYS A 627
ILE A 672
THR A 674
TYR A 676
CYH A 835
 748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.9A)
748  A1001 (-3.2A)
748  A1001 (-4.0A)
748  A1001 (-4.5A)
 0.67A 5hesB-5grnA:
17.9		 5hesB-5grnA:
28.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gz8 PROTEIN O-MANNOSE
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 VAL A  94
ALA A 105
ILE A 146
THR A 148
TYR A 150
 None
 0.25A 5hesB-5gz8A:
17.3		 5hesB-5gz8A:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  65
ALA A  77
ILE A 128
TYR A 132
CYH A 197
PHE A 199
 IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
None
IDV  A 401 (-3.5A)
IDV  A 401 (-3.6A)
None
 0.97A 5hesB-5i3oA:
21.2		 5hesB-5i3oA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  65
ALA A  77
LYS A  79
ILE A 128
CYH A 197
GLY A 200
 IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
IDV  A 401 ( 4.8A)
None
IDV  A 401 (-3.6A)
None
 1.24A 5hesB-5i3oA:
21.2		 5hesB-5i3oA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  65
ALA A  77
LYS A  79
ILE A 128
CYH A 197
PHE A 199
 IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
IDV  A 401 ( 4.8A)
None
IDV  A 401 (-3.6A)
None
 0.90A 5hesB-5i3oA:
21.2		 5hesB-5i3oA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idn CYCLIN-DEPENDENT
KINASE 8

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  35
ALA A  50
LYS A  52
TYR A  99
ALA A 100
GLY A 175
 6A7  A 401 ( 4.5A)
6A7  A 401 (-3.3A)
6A7  A 401 ( 2.9A)
6A7  A 401 (-4.9A)
6A7  A 401 (-3.7A)
FMT  A 404 ( 4.3A)
 0.99A 5hesB-5idnA:
21.2		 5hesB-5idnA:
27.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis) 		no annotation 6 VAL A  25
ALA A  38
LYS A  40
ILE A  90
TYR A  94
ASP A 102
 G93  A 301 (-3.4A)
G93  A 301 ( 3.7A)
G93  A 301 (-3.0A)
G93  A 301 ( 3.8A)
None
None
 0.79A 5hesB-5u94A:
23.6		 5hesB-5u94A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis) 		no annotation 6 VAL A  25
ALA A  38
LYS A  40
TYR A  94
ASP A 102
GLY A 158
 G93  A 301 (-3.4A)
G93  A 301 ( 3.7A)
G93  A 301 (-3.0A)
None
None
G93  A 301 ( 4.9A)
 1.35A 5hesB-5u94A:
23.6		 5hesB-5u94A:
14.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2

(Homo sapiens) 		no annotation 6 VAL A  32
ALA A  45
LYS A  47
ILE A  93
THR A  95
TYR A  97
 9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.9A)
9WS  A 401 (-3.2A)
None
 0.65A 5hesB-5w5jA:
26.1		 5hesB-5w5jA:
31.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 6 VAL A 899
ALA A 917
ILE A 961
THR A 963
TYR A 965
PHE A1029
 ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
None
ANP  A1201 (-3.9A)
ANP  A1201 (-4.4A)
None
 0.65A 5hesB-5wnoA:
25.9		 5hesB-5wnoA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 6 VAL A 899
ALA A 917
LYS A 919
ILE A 961
THR A 963
TYR A 965
 ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
None
ANP  A1201 (-3.9A)
ANP  A1201 (-4.4A)
 0.60A 5hesB-5wnoA:
25.9		 5hesB-5wnoA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		no annotation 6 VAL A  41
ALA A  54
ILE A  97
TYR A 101
PHE A 165
GLY A 166
 ANP  A 501 (-4.4A)
ANP  A 501 ( 3.7A)
None
ANP  A 501 ( 4.2A)
None
None
 0.81A 5hesB-6ao5A:
23.6		 5hesB-6ao5A:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bsz METABOTROPIC
GLUTAMATE RECEPTOR 8

(Homo sapiens) 		no annotation 6 GLY A  72
ALA A 177
TYR A 176
ALA A 153
ASP A 104
GLY A 228
 None
GGL  A 601 (-3.5A)
None
None
None
None
 1.18A 5hesB-6bszA:
undetectable		 5hesB-6bszA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1

(Homo sapiens) 		no annotation 6 VAL A 175
ALA A 189
LYS A 191
ILE A 239
ASP A 250
GLY A 327
 None
EAQ  A 501 (-3.6A)
EAQ  A 501 (-3.2A)
None
None
None
 0.97A 5hesB-6fyoA:
20.7		 5hesB-6fyoA:
undetectable