SIMILAR PATTERNS OF AMINO ACIDS FOR 5HES_A_032A401_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1by8 PROTEIN
(PROCATHEPSIN K)

(Homo sapiens) 		PF00112
(Peptidase_C1)
PF08246
(Inhibitor_I29) 		6 GLY A 267
VAL A 230
ALA A 309
ILE A  93
ALA A 219
GLY A 208
 None
 1.42A 5hesA-1by8A:
undetectable		 5hesA-1by8A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k25 LOW-AFFINITY
PENICILLIN-BINDING
PROTEIN 2X

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF03793
(PASTA) 		6 GLY A 500
VAL A 503
ALA A 508
ILE A 348
THR A 511
ALA A 469
 None
 1.43A 5hesA-1k25A:
undetectable		 5hesA-1k25A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k2p TYROSINE-PROTEIN
KINASE BTK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 428
ILE A 472
THR A 474
TYR A 476
PHE A 540
GLY A 541
 None
 0.80A 5hesA-1k2pA:
10.0		 5hesA-1k2pA:
29.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k2p TYROSINE-PROTEIN
KINASE BTK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 416
ALA A 428
ILE A 472
TYR A 476
PHE A 540
GLY A 541
 None
 0.73A 5hesA-1k2pA:
10.0		 5hesA-1k2pA:
29.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 VAL A 209
ALA A 220
ILE A 264
THR A 266
ASP A 276
PHE A 333
GLY A 334
 None
 0.99A 5hesA-1k9aA:
27.1		 5hesA-1k9aA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 VAL A 209
ALA A 220
ILE A 264
THR A 266
TYR A 268
ASP A 276
PHE A 333
 None
 0.85A 5hesA-1k9aA:
27.1		 5hesA-1k9aA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kae HISTIDINOL
DEHYDROGENASE

(Escherichia
coli) 		PF00815
(Histidinol_dh) 		6 GLY A 208
ALA A 217
ILE A  39
ILE A  32
ALA A 191
PHE A  58
 None
None
None
None
None
NAD  A1201 (-3.6A)
 1.39A 5hesA-1kaeA:
undetectable		 5hesA-1kaeA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 GLY A 268
VAL A 275
ALA A 288
ILE A 332
THR A 334
 P16  A   2 ( 4.3A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
 0.69A 5hesA-1opkA:
10.6		 5hesA-1opkA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9i DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  86
ALA A  99
ILE A 145
CYH A 211
PHE A 213
 ATP  A 535 (-4.1A)
ATP  A 535 (-3.6A)
5EA  A1001 ( 3.7A)
ATP  A 535 ( 4.5A)
5EA  A1001 (-3.6A)
 0.56A 5hesA-1s9iA:
8.3		 5hesA-1s9iA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		6 VAL A  42
ALA A  55
ILE A  89
TYR A 107
PHE A 170
GLY A 171
 None
 1.15A 5hesA-1u5qA:
23.4		 5hesA-1u5qA:
26.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL X  25
ALA X  37
ILE X  80
THR X  82
ASP X  92
 STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
None
STU  X 902 (-4.1A)
None
 0.43A 5hesA-2dq7X:
9.7		 5hesA-2dq7X:
29.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL X  25
ALA X  37
ILE X  80
THR X  82
TYR X  84
 STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
None
STU  X 902 (-4.1A)
STU  X 902 (-4.6A)
 0.58A 5hesA-2dq7X:
9.7		 5hesA-2dq7X:
29.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		6 VAL A  42
ALA A  55
ILE A  89
TYR A 107
PHE A 170
GLY A 171
 STU  A 400 ( 4.8A)
STU  A 400 (-3.2A)
STU  A 400 ( 4.5A)
STU  A 400 (-4.5A)
None
None
 1.03A 5hesA-2gcdA:
24.4		 5hesA-2gcdA:
27.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 ALA A 293
ILE A 336
THR A 338
ASP A 348
PHE A 405
GLY A 406
 H8H  A 534 (-3.2A)
H8H  A 534 ( 4.5A)
H8H  A 534 (-3.1A)
None
None
None
 0.88A 5hesA-2h8hA:
9.6		 5hesA-2h8hA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 VAL A 281
ALA A 293
ILE A 336
THR A 338
TYR A 340
ASP A 348
PHE A 405
 H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 ( 4.5A)
H8H  A 534 (-3.1A)
H8H  A 534 (-4.3A)
None
None
 0.85A 5hesA-2h8hA:
9.6		 5hesA-2h8hA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 VAL A 281
ALA A 293
ILE A 336
THR A 338
ASP A 348
PHE A 405
 QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.3A)
QUE  A   1 ( 4.1A)
None
 0.84A 5hesA-2hckA:
10.7		 5hesA-2hckA:
20.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hen EPHRIN TYPE-B
RECEPTOR 2

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 VAL A 643
ALA A 659
ILE A 691
ILE A 705
THR A 707
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
None
None
ADP  A 400 (-4.7A)
 0.41A 5hesA-2henA:
11.0		 5hesA-2henA:
31.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 259
ALA A 271
ILE A 314
THR A 316
ASP A 326
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
None
 0.59A 5hesA-2hk5A:
25.7		 5hesA-2hk5A:
26.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 256
ALA A 269
ILE A 313
THR A 315
ASP A 325
 GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.8A)
GIN  A 600 (-3.4A)
None
 0.63A 5hesA-2hz0A:
8.1		 5hesA-2hz0A:
32.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 259
ALA A 271
ILE A 314
THR A 316
TYR A 318
ASP A 326
 None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 4.6A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.7A)
None
 0.64A 5hesA-2og8A:
25.7		 5hesA-2og8A:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 495
ALA A 515
ILE A 548
ALA A 567
PHE A 645
GLY A 646
 None
 1.03A 5hesA-2psqA:
26.3		 5hesA-2psqA:
26.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 495
ALA A 515
ILE A 548
TYR A 566
ALA A 567
PHE A 645
 None
 0.83A 5hesA-2psqA:
26.3		 5hesA-2psqA:
26.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 204
ALA A 215
THR A 265
ASP A 275
PHE A 340
GLY A 341
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
ADE  A 488 (-4.3A)
None
None
None
 1.10A 5hesA-2qluA:
8.7		 5hesA-2qluA:
29.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qob EPHRIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 635
ALA A 651
ILE A 683
ILE A 697
THR A 699
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
 0.54A 5hesA-2qobA:
11.7		 5hesA-2qobA:
31.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		6 VAL A 689
ALA A 705
ILE A 737
ILE A 751
THR A 753
TYR A 755
 None
 0.59A 5hesA-2r2pA:
10.8		 5hesA-2r2pA:
27.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		6 VAL A 689
ALA A 705
ILE A 737
THR A 753
TYR A 755
PHE A 819
 None
 0.79A 5hesA-2r2pA:
10.8		 5hesA-2r2pA:
27.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 VAL A 635
ALA A 651
ILE A 683
ILE A 697
THR A 699
TYR A 701
 Q9G  A1898 ( 4.7A)
Q9G  A1898 (-3.2A)
Q9G  A1898 ( 4.9A)
Q9G  A1898 ( 4.6A)
Q9G  A1898 (-3.5A)
Q9G  A1898 (-4.8A)
 0.59A 5hesA-2xyuA:
11.2		 5hesA-2xyuA:
29.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y35 LD22664P

(Drosophila
melanogaster) 		PF03159
(XRN_N) 		6 GLY A 453
ALA A  92
ILE A 290
ALA A  89
ASP A 182
GLY A 286
 None
 1.35A 5hesA-2y35A:
undetectable		 5hesA-2y35A:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2m PENICILLIN-BINDING
PROTEIN 2X

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase) 		6 GLY B 500
VAL B 503
ALA B 508
ILE B 348
THR B 511
ALA B 469
 None
 1.47A 5hesA-2z2mB:
undetectable		 5hesA-2z2mB:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2w WEE1-LIKE PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A 313
ALA A 326
ILE A 374
TYR A 378
ASP A 386
 770  A 901 ( 4.7A)
770  A 901 (-3.5A)
None
770  A 901 (-4.2A)
None
 0.54A 5hesA-2z2wA:
22.2		 5hesA-2z2wA:
26.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 495
ALA A 515
ILE A 548
ALA A 567
PHE A 645
GLY A 646
 M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
M33  A1996 (-3.8A)
None
None
 1.05A 5hesA-3b2tA:
25.4		 5hesA-3b2tA:
30.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 495
ALA A 515
ILE A 548
TYR A 566
ALA A 567
PHE A 645
 M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
M33  A1996 ( 4.7A)
M33  A1996 (-3.8A)
None
 0.84A 5hesA-3b2tA:
25.4		 5hesA-3b2tA:
30.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 492
ALA A 512
ILE A 545
ALA A 564
PHE A 642
GLY A 643
 None
C4F  A   1 (-3.3A)
C4F  A   1 ( 4.0A)
C4F  A   1 (-3.5A)
C4F  A   1 ( 4.5A)
None
 0.88A 5hesA-3c4fA:
27.2		 5hesA-3c4fA:
30.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 209
ALA A 220
ILE A 264
THR A 266
ASP A 276
PHE A 333
GLY A 334
 None
 0.99A 5hesA-3d7uA:
27.4		 5hesA-3d7uA:
31.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 209
ALA A 220
ILE A 264
THR A 266
TYR A 268
ASP A 276
PHE A 333
 None
 0.85A 5hesA-3d7uA:
27.4		 5hesA-3d7uA:
31.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 158
ALA A 169
ILE A 204
ALA A 223
PHE A 295
 VIN  A6331 (-4.7A)
VIN  A6331 (-3.4A)
VIN  A6331 ( 4.9A)
VIN  A6331 (-3.8A)
None
 0.50A 5hesA-3dtcA:
14.8		 5hesA-3dtcA:
40.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		6 ALA A  36
ILE A  63
TYR A 119
CYH A 184
PHE A 186
GLY A 187
 DRK  A 384 (-3.5A)
DRK  A 384 ( 4.5A)
DRK  A 384 (-4.4A)
DRK  A 384 ( 3.8A)
None
None
 1.09A 5hesA-3eb0A:
5.8		 5hesA-3eb0A:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		6 VAL A  23
ALA A  36
ILE A  63
TYR A 119
CYH A 184
PHE A 186
 None
DRK  A 384 (-3.5A)
DRK  A 384 ( 4.5A)
DRK  A 384 (-4.4A)
DRK  A 384 ( 3.8A)
None
 1.02A 5hesA-3eb0A:
5.8		 5hesA-3eb0A:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  52
ALA A  65
ILE A 104
ASP A 131
PHE A 187
GLY A 188
 985  A   1 (-4.5A)
985  A   1 (-3.5A)
985  A   1 ( 4.7A)
None
None
None
 1.21A 5hesA-3f2aA:
7.0		 5hesA-3f2aA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbz KINASE, CMGC CDK

(Giardia
intestinalis) 		PF00069
(Pkinase) 		5 VAL A  29
ALA A  42
ILE A  75
TYR A  93
ALA A  94
 None
 0.56A 5hesA-3gbzA:
23.7		 5hesA-3gbzA:
24.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kex RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 704
THR A 768
TYR A 770
ASP A 778
PHE A 834
 ANP  A   1 (-3.9A)
ANP  A   1 ( 4.8A)
ANP  A   1 (-4.3A)
None
None
 0.70A 5hesA-3kexA:
27.1		 5hesA-3kexA:
30.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		6 ALA A 665
ILE A 697
ILE A 711
THR A 713
TYR A 715
PHE A 779
 None
None
None
None
GOL  A 403 (-4.1A)
None
 0.84A 5hesA-3kulA:
10.6		 5hesA-3kulA:
30.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 VAL A 649
ALA A 665
ILE A 697
ILE A 711
THR A 713
PHE A 779
GLY A 780
 None
 1.09A 5hesA-3kulA:
10.6		 5hesA-3kulA:
30.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		5 VAL A 689
ALA A 700
ILE A 729
ILE A 743
ASP A 754
 ADP  A2101 (-4.5A)
ADP  A2101 (-3.5A)
None
None
ADP  A2101 ( 4.9A)
 0.56A 5hesA-3lj0A:
6.7		 5hesA-3lj0A:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  47
ALA A  60
ILE A  94
TYR A 112
ALA A 113
PHE A 180
 QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.6A)
QUE  A   1 (-4.9A)
QUE  A   1 (-3.9A)
None
 0.91A 5hesA-3lm5A:
10.4		 5hesA-3lm5A:
26.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n9x PHOSPHOTRANSFERASE

(Plasmodium
berghei) 		PF00069
(Pkinase) 		6 VAL A  42
ALA A  55
ILE A  88
ILE A 107
ALA A 112
CYH A 171
 None
GOL  A 434 ( 4.1A)
None
None
GOL  A 434 (-3.9A)
GOL  A 433 ( 3.7A)
 0.71A 5hesA-3n9xA:
20.0		 5hesA-3n9xA:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nie MAP2 KINASE

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		6 VAL A  44
ALA A  57
ILE A  90
ILE A 109
ALA A 114
CYH A 173
 ANP  A 430 (-4.2A)
ANP  A 430 (-3.5A)
ANP  A 430 ( 4.5A)
None
ANP  A 430 (-3.9A)
ANP  A 430 ( 3.8A)
 0.64A 5hesA-3nieA:
6.1		 5hesA-3nieA:
26.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		7 VAL A 565
ALA A 576
ILE A 623
THR A 625
CYH A 693
PHE A 695
GLY A 696
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
None
STU  A   1 (-4.1A)
STU  A   1 (-3.5A)
None
None
 1.07A 5hesA-3ppzA:
10.3		 5hesA-3ppzA:
35.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		7 VAL A 565
ALA A 576
ILE A 623
THR A 625
TYR A 627
CYH A 693
PHE A 695
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
None
STU  A   1 (-4.1A)
STU  A   1 (-4.4A)
STU  A   1 (-3.5A)
None
 0.86A 5hesA-3ppzA:
10.3		 5hesA-3ppzA:
35.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 431
ALA A 443
ILE A 487
THR A 489
TYR A 491
 PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 (-3.6A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.9A)
 0.45A 5hesA-3sxsA:
10.4		 5hesA-3sxsA:
31.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 492
ALA A 512
ILE A 545
TYR A 563
ALA A 564
PHE A 642
GLY A 643
 07J  A   1 (-4.0A)
07J  A   1 (-3.5A)
07J  A   1 (-3.8A)
07J  A   1 (-4.7A)
07J  A   1 (-3.8A)
07J  A   1 ( 4.6A)
None
 0.88A 5hesA-3tt0A:
25.8		 5hesA-3tt0A:
28.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3uc3 SERINE/THREONINE-PRO
TEIN KINASE SRK2I

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		6 ALA A  49
ILE A  93
TYR A  97
ALA A  98
CYH A 160
GLY A 163
 None
None
None
None
CO  A 363 (-2.0A)
None
 1.26A 5hesA-3uc3A:
8.7		 5hesA-3uc3A:
30.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wn6 ALPHA-AMYLASE

(Oryza sativa) 		PF00128
(Alpha-amylase)
PF07821
(Alpha-amyl_C2) 		6 ILE A 299
ILE A 276
THR A 273
ALA A 306
ASP A 257
GLY A 290
 None
None
None
None
TAR  A 507 ( 4.5A)
None
 1.31A 5hesA-3wn6A:
undetectable		 5hesA-3wn6A:
21.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 633
ALA A 649
ILE A 681
ILE A 695
THR A 697
 None
 0.44A 5hesA-3zfxA:
10.9		 5hesA-3zfxA:
31.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 105
ALA A 121
ILE A 153
ILE A 167
THR A 169
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
None
None
30K  A1365 (-3.8A)
 0.43A 5hesA-4aw5A:
11.1		 5hesA-4aw5A:
31.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE

(Candida
albicans) 		PF00069
(Pkinase) 		6 VAL A 254
ALA A 267
ILE A 302
TYR A 320
ALA A 321
PHE A 383
 None
 0.86A 5hesA-4c0tA:
7.1		 5hesA-4c0tA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 624
ALA A 653
ILE A 685
THR A 701
TYR A 703
 DI1  A1000 (-4.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-4.5A)
DI1  A1000 (-3.6A)
DI1  A1000 (-4.0A)
 0.61A 5hesA-4ckrA:
9.6		 5hesA-4ckrA:
27.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4egs RIBOSE 5-PHOSPHATE
ISOMERASE RPIB

(Caldanaerobacter
subterraneus) 		PF01451
(LMWPc) 		6 GLY A  60
VAL A  54
ALA A 132
THR A 131
ALA A  17
GLY A 122
 GLY  A  60 ( 0.0A)
VAL  A  54 ( 0.6A)
ALA  A 132 ( 0.0A)
THR  A 131 ( 0.8A)
ALA  A  17 ( 0.0A)
GLY  A 122 ( 0.0A)
 1.43A 5hesA-4egsA:
undetectable		 5hesA-4egsA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gic HISTIDINOL
DEHYDROGENASE

(Methylococcus
capsulatus) 		PF00815
(Histidinol_dh) 		6 GLY A 216
ALA A 225
ILE A  41
ILE A  34
ALA A 199
PHE A  60
 None
 1.46A 5hesA-4gicA:
undetectable		 5hesA-4gicA:
19.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hzs ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14604
(SH3_9) 		6 ILE A 190
THR A 205
ALA A 208
ASP A 215
PHE A 271
GLY A 272
 None
 0.83A 5hesA-4hzsA:
13.7		 5hesA-4hzsA:
33.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hzs ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14604
(SH3_9) 		7 VAL A 140
ALA A 156
ILE A 190
THR A 205
ALA A 208
ASP A 215
PHE A 271
 None
 0.72A 5hesA-4hzsA:
13.7		 5hesA-4hzsA:
33.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4id7 ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 140
ALA A 156
ILE A 190
THR A 205
ALA A 208
ASP A 215
PHE A 271
 1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-4.3A)
1G0  A 401 (-3.2A)
1G0  A 401 (-3.8A)
None
1G0  A 401 ( 4.8A)
 0.95A 5hesA-4id7A:
9.5		 5hesA-4id7A:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 VAL A 281
ALA A 293
ILE A 336
TYR A 340
PHE A 405
 0J9  A 601 (-4.4A)
0J9  A 601 (-3.3A)
0J9  A 601 (-4.4A)
0J9  A 601 ( 4.7A)
None
 0.45A 5hesA-4k11A:
9.5		 5hesA-4k11A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 486
ALA A 506
ILE A 539
ALA A 558
PHE A 636
GLY A 637
 ACP  A 801 (-4.2A)
ACP  A 801 (-3.3A)
None
ACP  A 801 (-3.7A)
None
None
 1.15A 5hesA-4k33A:
10.1		 5hesA-4k33A:
29.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 486
ALA A 506
ILE A 539
TYR A 557
ALA A 558
PHE A 636
 ACP  A 801 (-4.2A)
ACP  A 801 (-3.3A)
None
None
ACP  A 801 (-3.7A)
None
 0.94A 5hesA-4k33A:
10.1		 5hesA-4k33A:
29.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL B  38
ALA B  51
ILE B  97
TYR B 101
ASP B 109
PHE B 163
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
None
ADP  B 500 ( 4.7A)
None
None
 0.85A 5hesA-4o27B:
24.3		 5hesA-4o27B:
30.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p2k EPHRIN TYPE-A
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		6 VAL A 627
ALA A 644
ILE A 676
ILE A 690
THR A 692
TYR A 694
 None
 0.55A 5hesA-4p2kA:
10.7		 5hesA-4p2kA:
30.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q1q ADHESIN/INVASIN TIBA
AUTOTRANSPORTER

(Escherichia
coli) 		PF16168
(AIDA) 		6 GLY A 228
VAL A 206
ALA A 212
THR A 215
ALA A 232
GLY A 221
 None
None
None
None
289  A 416 (-3.5A)
None
 1.32A 5hesA-4q1qA:
undetectable		 5hesA-4q1qA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qny MITOGEN ACTIVATED
PROTEIN KINASE,
PUTATIVE

(Leishmania
donovani) 		PF00069
(Pkinase) 		5 VAL A  35
ALA A  49
ILE A  83
ILE A 102
CYH A 166
 ANP  A 402 (-4.3A)
ANP  A 402 (-3.3A)
ANP  A 402 (-4.8A)
None
ANP  A 402 ( 4.3A)
 0.54A 5hesA-4qnyA:
6.1		 5hesA-4qnyA:
26.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qtb MITOGEN-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  56
ALA A  69
ILE A 101
ILE A 120
CYH A 183
 None
38Z  A 418 (-3.4A)
38Z  A 418 ( 4.9A)
None
38Z  A 418 ( 3.8A)
 0.68A 5hesA-4qtbA:
20.3		 5hesA-4qtbA:
27.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		6 VAL A  32
ALA A  45
ILE A  79
TYR A  97
ASP A 105
GLY A 161
 STU  A 601 ( 4.8A)
STU  A 601 (-3.2A)
STU  A 601 ( 4.6A)
STU  A 601 (-4.4A)
None
None
 1.20A 5hesA-4rewA:
7.4		 5hesA-4rewA:
21.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		6 VAL A  22
ALA A  35
ILE A  79
THR A  81
TYR A  83
ASP A  91
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
None
 0.61A 5hesA-4ueuA:
14.0		 5hesA-4ueuA:
32.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		6 VAL A  22
ALA A  35
THR A  81
TYR A  83
ASP A  91
PHE A 148
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
None
None
 0.91A 5hesA-4ueuA:
14.0		 5hesA-4ueuA:
32.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uy9 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A 158
ALA A 169
ILE A 204
ALA A 223
PHE A 295
 None
 0.53A 5hesA-4uy9A:
32.8		 5hesA-4uy9A:
40.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  60
ALA A  72
ILE A 124
CYH A 193
PHE A 195
GLY A 196
 KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
KSA  A 405 (-3.4A)
None
None
 1.11A 5hesA-4wsqA:
7.1		 5hesA-4wsqA:
24.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 501
ILE A 534
ALA A 553
PHE A 631
GLY A 632
 40M  A1002 ( 4.1A)
40M  A1002 (-4.0A)
40M  A1002 (-3.7A)
40M  A1002 ( 4.2A)
None
 0.68A 5hesA-4xcuA:
26.4		 5hesA-4xcuA:
30.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 481
ALA A 501
ILE A 534
ALA A 553
PHE A 631
 40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-4.0A)
40M  A1002 (-3.7A)
40M  A1002 ( 4.2A)
 0.61A 5hesA-4xcuA:
26.4		 5hesA-4xcuA:
30.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 5 VAL B 275
ALA B 288
ILE B 332
THR B 334
ASP B 344
 1N1  B 601 ( 4.9A)
1N1  B 601 (-3.5A)
1N1  B 601 (-4.1A)
1N1  B 601 (-3.3A)
None
 0.59A 5hesA-4xeyB:
25.9		 5hesA-4xeyB:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 VAL A 416
ALA A 428
ILE A 472
THR A 474
TYR A 476
PHE A 540
 None
 0.83A 5hesA-4xi2A:
10.0		 5hesA-4xi2A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		6 VAL A 416
ALA A 428
ILE A 472
THR A 474
TYR A 476
PHE A 540
 746  A 702 ( 4.3A)
746  A 702 (-2.4A)
None
746  A 702 (-3.7A)
746  A 702 (-4.4A)
None
 0.73A 5hesA-4y93A:
14.5		 5hesA-4y93A:
19.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 488
ILE A 522
ILE A 537
THR A 539
TYR A 541
GLY A 608
 4CV  A 801 (-3.5A)
4CV  A 801 ( 4.2A)
None
4CV  A 801 (-2.8A)
4CV  A 801 (-3.9A)
None
 0.80A 5hesA-4yffA:
8.4		 5hesA-4yffA:
31.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 488
ILE A 522
THR A 539
TYR A 541
PHE A 607
GLY A 608
 4CV  A 801 (-3.5A)
4CV  A 801 ( 4.2A)
4CV  A 801 (-2.8A)
4CV  A 801 (-3.9A)
None
None
 1.04A 5hesA-4yffA:
8.4		 5hesA-4yffA:
31.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 477
ALA A 488
ILE A 522
ILE A 537
THR A 539
TYR A 541
 None
4CV  A 801 (-3.5A)
4CV  A 801 ( 4.2A)
None
4CV  A 801 (-2.8A)
4CV  A 801 (-3.9A)
 0.48A 5hesA-4yffA:
8.4		 5hesA-4yffA:
31.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 477
ALA A 488
ILE A 522
THR A 539
TYR A 541
PHE A 607
 None
4CV  A 801 (-3.5A)
4CV  A 801 ( 4.2A)
4CV  A 801 (-2.8A)
4CV  A 801 (-3.9A)
None
 0.84A 5hesA-4yffA:
8.4		 5hesA-4yffA:
31.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 492
ALA A 512
ILE A 545
TYR A 563
ALA A 564
PHE A 642
GLY A 643
 38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.3A)
38O  A1769 (-4.2A)
38O  A1769 (-3.9A)
EDO  A1766 (-3.7A)
EDO  A1766 (-3.6A)
 0.85A 5hesA-5a46A:
2.4		 5hesA-5a46A:
30.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		6 ALA A 134
ILE A 130
THR A 131
TYR A 133
ALA A 150
GLY A  84
 None
 1.45A 5hesA-5ahkA:
undetectable		 5hesA-5ahkA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		6 VAL A  70
ALA A  83
TYR A 134
ALA A 135
ASP A 142
GLY A 198
 5RC  A4000 (-4.6A)
5RC  A4000 (-3.6A)
5RC  A4000 (-4.5A)
5RC  A4000 (-3.7A)
None
None
 1.15A 5hesA-5es1A:
7.5		 5hesA-5es1A:
27.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		6 VAL A  70
TYR A 134
ALA A 135
ASP A 142
PHE A 197
GLY A 198
 5RC  A4000 (-4.6A)
5RC  A4000 (-4.5A)
5RC  A4000 (-3.7A)
None
None
None
 1.33A 5hesA-5es1A:
7.5		 5hesA-5es1A:
27.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 911
ALA A 928
ILE A 960
TYR A 980
ASP A 988
PHE A1042
 5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
5U3  A1200 (-4.6A)
5U3  A1200 (-4.5A)
None
None
 1.06A 5hesA-5f1zA:
24.9		 5hesA-5f1zA:
29.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fd2 SERINE/THREONINE-PRO
TEIN KINASE B-RAF

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 471
ALA A 481
ILE A 527
THR A 529
PHE A 595
GLY A 596
 5XJ  A 801 (-4.6A)
5XJ  A 801 (-3.1A)
5XJ  A 801 ( 4.0A)
5XJ  A 801 (-3.4A)
5XJ  A 801 (-3.7A)
5XJ  A 801 (-3.7A)
 0.37A 5hesA-5fd2A:
10.2		 5hesA-5fd2A:
31.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 607
ALA A 625
ILE A 672
THR A 674
TYR A 676
CYH A 835
 748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.9A)
748  A1001 (-3.2A)
748  A1001 (-4.0A)
748  A1001 (-4.5A)
 0.72A 5hesA-5grnA:
9.7		 5hesA-5grnA:
28.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gz8 PROTEIN O-MANNOSE
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 VAL A  94
ALA A 105
ILE A 146
THR A 148
GLY A 121
 None
 0.64A 5hesA-5gz8A:
17.1		 5hesA-5gz8A:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gz8 PROTEIN O-MANNOSE
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 VAL A  94
ALA A 105
ILE A 146
THR A 148
TYR A 150
 None
 0.26A 5hesA-5gz8A:
17.1		 5hesA-5gz8A:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hor HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A1092
ALA A1108
TYR A1159
PHE A1223
GLY A1224
 63K  A1401 (-4.9A)
63K  A1401 (-3.5A)
63K  A1401 (-3.5A)
None
None
 0.69A 5hesA-5horA:
11.1		 5hesA-5horA:
28.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  65
ALA A  77
ILE A 128
TYR A 132
CYH A 197
PHE A 199
 IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
None
IDV  A 401 (-3.5A)
IDV  A 401 (-3.6A)
None
 0.93A 5hesA-5i3oA:
21.3		 5hesA-5i3oA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idn CYCLIN-DEPENDENT
KINASE 8

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  35
ALA A  50
ILE A  79
TYR A  99
ALA A 100
GLY A 175
 6A7  A 401 ( 4.5A)
6A7  A 401 (-3.3A)
6A7  A 401 (-4.2A)
6A7  A 401 (-4.9A)
6A7  A 401 (-3.7A)
FMT  A 404 ( 4.3A)
 0.97A 5hesA-5idnA:
7.2		 5hesA-5idnA:
27.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kkr KINASE SUPPRESSOR OF
RAS 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL B 680
ALA B 690
ILE B 737
THR B 739
PHE B 804
 6U7  B1001 ( 4.3A)
6U7  B1001 (-3.6A)
6U7  B1001 ( 4.1A)
6U7  B1001 (-4.0A)
6U7  B1001 (-3.8A)
 0.70A 5hesA-5kkrB:
9.1		 5hesA-5kkrB:
28.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l6o EPHRIN TYPE-B
RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 647
ALA A 663
ILE A 695
ILE A 709
THR A 711
 None
6P6  A1001 (-3.3A)
None
6P6  A1001 ( 4.5A)
6P6  A1001 (-3.5A)
 0.48A 5hesA-5l6oA:
11.9		 5hesA-5l6oA:
30.42