SIMILAR PATTERNS OF AMINO ACIDS FOR 5HBS_A_RTLA201_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
12as ASPARAGINE
SYNTHETASE

(Escherichia
coli) 		PF03590
(AsnA) 		4 LEU A 261
THR A  44
GLN A  83
MET A 287
 None
 1.13A 5hbsA-12asA:
0.2		 5hbsA-12asA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a6j NITROGEN REGULATORY
IIA PROTEIN

(Escherichia
coli) 		PF00359
(PTS_EIIA_2) 		4 LEU A 106
THR A  19
TYR A 150
GLN A  42
 None
 1.20A 5hbsA-1a6jA:
undetectable		 5hbsA-1a6jA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fbw ENDO-1,4-BETA-GLUCAN
ASE F

([Clostridium]
cellulolyticum) 		PF02011
(Glyco_hydro_48) 		4 LEU A 149
THR A 226
TYR A 299
GLN A 194
 None
GLC  A3097 ( 3.0A)
GLC  A3097 ( 4.1A)
None
 1.19A 5hbsA-1fbwA:
0.0		 5hbsA-1fbwA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gg4 UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMYL-2,
6-DIAMINOPIMELATE-D-
ALANYL-D-ALANYL
LIGASE

(Escherichia
coli) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 LEU A 105
THR A 128
TYR A 130
GLN A 124
 None
 1.14A 5hbsA-1gg4A:
0.0		 5hbsA-1gg4A:
13.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ggl PROTEIN (CELLULAR
RETINOL-BINDING
PROTEIN III)

(Homo sapiens) 		PF00061
(Lipocalin) 		6 LEU A  20
LEU A  36
LYS A  40
THR A  53
TYR A  60
TRP A 106
 None
 0.51A 5hbsA-1gglA:
23.2		 5hbsA-1gglA:
53.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kl7 THREONINE SYNTHASE

(Saccharomyces
cerevisiae) 		PF00291
(PALP)
PF14821
(Thr_synth_N) 		4 LEU A  99
LEU A 447
THR A 430
TYR A 444
 None
 1.11A 5hbsA-1kl7A:
0.0		 5hbsA-1kl7A:
13.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kqx CELLULAR
RETINOL-BINDING
PROTEIN

(Danio rerio) 		PF00061
(Lipocalin) 		5 LEU A  36
LYS A  40
THR A  53
TRP A 106
GLN A 108
 None
 0.85A 5hbsA-1kqxA:
24.2		 5hbsA-1kqxA:
58.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l6w FRUCTOSE-6-PHOSPHATE
ALDOLASE 1

(Escherichia
coli) 		PF00923
(TAL_FSA) 		4 LEU A 149
LEU A 119
TYR A 112
GLN A  59
 None
 1.11A 5hbsA-1l6wA:
0.0		 5hbsA-1l6wA:
19.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lpj RETINOL-BINDING
PROTEIN IV, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		5 LEU A  36
LYS A  40
THR A  53
TRP A 106
MET A 119
 None
 0.58A 5hbsA-1lpjA:
23.8		 5hbsA-1lpjA:
55.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m7j D-AMINOACYLASE

(Alcaligenes
faecalis) 		PF07969
(Amidohydro_3) 		4 LEU A 115
THR A  68
GLN A  86
MET A  80
 None
 1.17A 5hbsA-1m7jA:
undetectable		 5hbsA-1m7jA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nun FIBROBLAST GROWTH
FACTOR-10

(Homo sapiens) 		PF00167
(FGF) 		4 LEU A 132
LEU A 180
THR A 192
TYR A 177
 None
 1.18A 5hbsA-1nunA:
undetectable		 5hbsA-1nunA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1poy SPERMIDINE/PUTRESCIN
E-BINDING PROTEIN

(Escherichia
coli) 		PF13416
(SBP_bac_8) 		4 LEU 1 110
LEU 1 104
TYR 1 129
GLN 1 286
 None
 1.14A 5hbsA-1poy1:
undetectable		 5hbsA-1poy1:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szq 2-METHYLCITRATE
DEHYDRATASE

(Escherichia
coli) 		PF03972
(MmgE_PrpD) 		4 LEU A 145
LEU A 121
THR A  44
MET A 278
 None
 1.12A 5hbsA-1szqA:
undetectable		 5hbsA-1szqA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tpy METHOXY MYCOLIC ACID
SYNTHASE 2

(Mycobacterium
tuberculosis) 		PF02353
(CMAS) 		4 LEU A 222
LEU A 166
THR A 170
GLN A 229
 None
 1.13A 5hbsA-1tpyA:
undetectable		 5hbsA-1tpyA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u7h ORNITHINE
CYCLODEAMINASE

(Pseudomonas
putida) 		PF02423
(OCD_Mu_crystall) 		4 LEU A 105
LEU A  91
TYR A 306
MET A  10
 None
 1.10A 5hbsA-1u7hA:
0.8		 5hbsA-1u7hA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wac P2 PROTEIN

(Pseudomonas
virus phi6) 		PF00680
(RdRP_1) 		4 LEU A 471
LEU A 415
THR A 409
TYR A 410
 None
 1.03A 5hbsA-1wacA:
undetectable		 5hbsA-1wacA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygu LEUKOCYTE COMMON
ANTIGEN

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 LEU A 897
LEU A1161
TYR A1197
GLN A1174
 None
 1.16A 5hbsA-1yguA:
undetectable		 5hbsA-1yguA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yr7 ATP(GTP)BINDING
PROTEIN

(Pyrococcus
abyssi) 		PF03029
(ATP_bind_1) 		4 LEU A 222
LEU A 236
THR A 160
TYR A 129
 None
 1.10A 5hbsA-1yr7A:
undetectable		 5hbsA-1yr7A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z9a NAD(P)H-DEPENDENT
D-XYLOSE REDUCTASE

([Candida]
tenuis) 		PF00248
(Aldo_ket_red) 		4 LEU A 260
LEU A 303
THR A 236
GLN A 230
 None
 1.17A 5hbsA-1z9aA:
undetectable		 5hbsA-1z9aA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ecf DIPEPTIDYL PEPTIDASE
IV

(Stenotrophomonas
maltophilia) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 LEU A 619
LEU A 558
THR A 531
TYR A 524
 None
 1.14A 5hbsA-2ecfA:
undetectable		 5hbsA-2ecfA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gdt LEADER PROTEIN
P65 HOMOLOG
NSP1 (EC 3.4.22.-)

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF11501
(Nsp1) 		4 LEU A  53
LEU A  96
THR A  92
GLN A  85
 None
 1.20A 5hbsA-2gdtA:
undetectable		 5hbsA-2gdtA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA

(Homo sapiens) 		PF00899
(ThiF)
PF08825
(E2_bind)
PF13416
(SBP_bac_8) 		4 LEU B1291
LEU B1263
THR B1094
GLN B1326
 None
 1.18A 5hbsA-2nvuB:
undetectable		 5hbsA-2nvuB:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ol3 ALLOGENEIC H-2KBM8
MHC CLASS I MOLECULE

(Mus musculus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 LEU H 156
LYS H  66
TYR H   7
TRP H 167
 None
 1.21A 5hbsA-2ol3H:
undetectable		 5hbsA-2ol3H:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pjr PROTEIN (HELICASE
PCRA)
PROTEIN (HELICASE
PCRA)

(Geobacillus
stearothermophilus;
Geobacillus
stearothermophilus) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C)
PF13361
(UvrD_C) 		4 THR B 618
TYR A 324
GLN A 363
MET A 367
 None
 1.20A 5hbsA-2pjrB:
undetectable		 5hbsA-2pjrB:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ppg PUTATIVE ISOMERASE

(Sinorhizobium
meliloti) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 374
LEU A 145
GLN A 298
MET A 291
 None
 1.18A 5hbsA-2ppgA:
undetectable		 5hbsA-2ppgA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyj DNA POLYMERASE

(Bacillus virus
phi29) 		PF03175
(DNA_pol_B_2) 		4 LEU A 342
LEU A 328
THR A 301
GLN A 446
 None
 1.13A 5hbsA-2pyjA:
undetectable		 5hbsA-2pyjA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qsx PUTATIVE
TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY

(Vibrio
parahaemolyticus) 		PF03466
(LysR_substrate) 		4 LEU A 211
LEU A  31
THR A  23
GLN A 112
 None
None
SO4  A 216 ( 3.2A)
SO4  A 216 ( 4.4A)
 1.10A 5hbsA-2qsxA:
undetectable		 5hbsA-2qsxA:
19.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rcq RETINOL-BINDING
PROTEIN II, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		4 LYS A  40
THR A  53
TRP A 106
GLN A 108
 None
 0.49A 5hbsA-2rcqA:
24.0		 5hbsA-2rcqA:
51.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7b BENZOATE-COENZYME A
LIGASE

(Paraburkholderia
xenovorans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 LEU A 365
LEU A 417
THR A 354
TYR A 424
 None
 1.17A 5hbsA-2v7bA:
undetectable		 5hbsA-2v7bA:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vmf BETA-MANNOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2) 		4 LEU A 114
LEU A 152
TYR A 155
TRP A  89
 None
 1.17A 5hbsA-2vmfA:
undetectable		 5hbsA-2vmfA:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3a PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT BETA ISOFORM

(Mus musculus) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
PF02192
(PI3K_p85B) 		4 LEU A 633
LEU A 640
TYR A 692
TRP A 670
 None
 1.17A 5hbsA-2y3aA:
undetectable		 5hbsA-2y3aA:
8.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfs LEVANSUCRASE

(Lactobacillus
johnsonii) 		PF02435
(Glyco_hydro_68) 		4 LEU A 476
LEU A 469
GLN A 219
MET A 518
 None
 1.16A 5hbsA-2yfsA:
undetectable		 5hbsA-2yfsA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1b DELTA-AMINOLEVULINIC
ACID DEHYDRATASE

(Mus musculus) 		PF00490
(ALAD) 		4 LEU A 273
LEU A 258
TYR A 276
GLN A 225
 None
 0.97A 5hbsA-2z1bA:
undetectable		 5hbsA-2z1bA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b5o CADD-LIKE PROTEIN OF
UNKNOWN FUNCTION

(Nostoc
punctiforme) 		PF12981
(DUF3865) 		4 LEU A 171
LEU A 152
TYR A  95
GLN A  46
 None
 1.07A 5hbsA-3b5oA:
undetectable		 5hbsA-3b5oA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bmw CYCLOMALTODEXTRIN
GLUCANOTRANSFERASE

(Thermoanaerobacterium
thermosulfurigenes) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		4 LEU A 397
LEU A 460
THR A 457
TYR A 456
 None
 1.12A 5hbsA-3bmwA:
undetectable		 5hbsA-3bmwA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmi PEROXIREDOXIN HYR1

(Saccharomyces
cerevisiae) 		PF00255
(GSHPx) 		4 LEU A 159
LEU A 131
TYR A  49
GLN A  21
 None
 1.16A 5hbsA-3cmiA:
undetectable		 5hbsA-3cmiA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cnj CHOLESTEROL OXIDASE

(Streptomyces
sp. SA-COO) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 LEU A 292
LEU A 449
TYR A 446
MET A 104
 None
None
FAD  A 510 (-3.6A)
None
 1.18A 5hbsA-3cnjA:
undetectable		 5hbsA-3cnjA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctp PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR

(Alkaliphilus
metalliredigens) 		PF13377
(Peripla_BP_3) 		4 LEU A 112
LEU A  95
THR A  92
TYR A  91
 None
 1.13A 5hbsA-3ctpA:
undetectable		 5hbsA-3ctpA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e23 UNCHARACTERIZED
PROTEIN RPA2492

(Rhodopseudomonas
palustris) 		PF08241
(Methyltransf_11) 		4 LEU A  41
LEU A 131
TYR A 138
MET A  61
 None
 1.01A 5hbsA-3e23A:
undetectable		 5hbsA-3e23A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eaf ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN

(Aeropyrum
pernix) 		PF13458
(Peripla_BP_6) 		4 LEU A 185
LEU A 270
TYR A 189
MET A 236
 None
 1.16A 5hbsA-3eafA:
undetectable		 5hbsA-3eafA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3if2 AMINOTRANSFERASE

(Psychrobacter
arcticus) 		PF00155
(Aminotran_1_2) 		4 LEU A 351
LEU A 439
THR A 378
TRP A 368
 None
 1.09A 5hbsA-3if2A:
undetectable		 5hbsA-3if2A:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ig4 XAA-PRO
AMINOPEPTIDASE

(Bacillus
anthracis) 		PF00557
(Peptidase_M24)
PF05195
(AMP_N) 		4 LEU A 317
LEU A 293
THR A 271
GLN A 282
 None
 1.08A 5hbsA-3ig4A:
undetectable		 5hbsA-3ig4A:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9b LIVER
CARBOXYLESTERASE 1

(Homo sapiens) 		PF00135
(COesterase) 		4 LEU A1110
LEU A1051
THR A1167
TYR A1152
 None
 1.03A 5hbsA-3k9bA:
undetectable		 5hbsA-3k9bA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvu TENA FAMILY
TRANSCRIPTIONAL
REGULATOR

(Ruegeria sp.
TM1040) 		PF03070
(TENA_THI-4) 		4 LEU A  83
LEU A 137
THR A 118
GLN A  48
 None
None
None
CL  A 239 (-4.0A)
 1.10A 5hbsA-3mvuA:
undetectable		 5hbsA-3mvuA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n28 PHOSPHOSERINE
PHOSPHATASE

(Vibrio cholerae) 		PF00702
(Hydrolase) 		4 LEU A  75
TYR A  95
GLN A  48
MET A  52
 None
 1.15A 5hbsA-3n28A:
undetectable		 5hbsA-3n28A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nfz ASPARTOACYLASE-2

(Mus musculus) 		PF04952
(AstE_AspA) 		4 LEU A 115
LEU A  52
TYR A  33
GLN A  42
 None
 1.19A 5hbsA-3nfzA:
undetectable		 5hbsA-3nfzA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ny7 SULFATE TRANSPORTER

(Escherichia
coli) 		PF01740
(STAS) 		4 LEU A 537
LEU A 483
GLN A 520
MET A 525
 None
 1.14A 5hbsA-3ny7A:
undetectable		 5hbsA-3ny7A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfe SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Legionella
pneumophila) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 LEU A 448
LEU A 456
THR A 139
GLN A  13
 None
 1.05A 5hbsA-3pfeA:
undetectable		 5hbsA-3pfeA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9n CONSENSUS ANKYRIN
REPEAT

(Escherichia
coli) 		PF12796
(Ank_2)
PF13637
(Ank_4) 		4 LEU C 120
LEU C  87
TYR C  77
TRP C 102
 None
 1.18A 5hbsA-3q9nC:
undetectable		 5hbsA-3q9nC:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qc5 PLATELET BINDING
PROTEIN GSPB

(Streptococcus
gordonii) 		no annotation 4 LEU X 373
THR X 382
GLN X 288
MET X 263
 None
 1.07A 5hbsA-3qc5X:
undetectable		 5hbsA-3qc5X:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6p BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 2

(Homo sapiens) 		PF00619
(CARD)
PF00653
(BIR)
PF13920
(zf-C3HC4_3) 		4 LEU A 313
LYS A 416
THR A 420
TYR A 352
 None
 1.16A 5hbsA-3t6pA:
undetectable		 5hbsA-3t6pA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4av2 PILP PROTEIN

(Neisseria
meningitidis) 		PF04351
(PilP) 		4 LEU M 143
LEU M 146
TYR M 125
MET M  95
 None
 1.18A 5hbsA-4av2M:
undetectable		 5hbsA-4av2M:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eco UNCHARACTERIZED
PROTEIN

(Bacteroides
eggerthii) 		no annotation 4 LEU A 476
LEU A 354
TYR A 480
GLN A 405
 None
 1.01A 5hbsA-4ecoA:
undetectable		 5hbsA-4ecoA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f92 U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		4 LEU B 897
LEU B 409
TYR B 936
GLN B 418
 None
 1.14A 5hbsA-4f92B:
undetectable		 5hbsA-4f92B:
6.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fys AMINOPEPTIDASE N

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 LEU A 521
LEU A 484
THR A 544
TYR A 514
 None
 1.10A 5hbsA-4fysA:
undetectable		 5hbsA-4fysA:
8.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gmf YERSINIABACTIN
BIOSYNTHETIC PROTEIN
YBTU

(Yersinia
enterocolitica) 		PF01408
(GFO_IDH_MocA) 		4 LEU A 228
LEU A 138
THR A 131
TYR A 128
 None
 0.91A 5hbsA-4gmfA:
1.8		 5hbsA-4gmfA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h19 MANDELATE RACEMASE

(Agrobacterium
fabrum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 326
LEU A 316
THR A 280
GLN A 256
 None
 1.13A 5hbsA-4h19A:
0.2		 5hbsA-4h19A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h6y FERM, RHOGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00169
(PH)
PF00621
(RhoGEF) 		4 LEU A 606
LEU A 599
THR A 551
GLN A 694
 None
 1.07A 5hbsA-4h6yA:
undetectable		 5hbsA-4h6yA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hi2 ACYLPHOSPHATASE

(Vibrio cholerae) 		PF00708
(Acylphosphatase) 		4 LEU A  58
LEU A  28
TYR A  35
GLN A  15
 None
 1.19A 5hbsA-4hi2A:
undetectable		 5hbsA-4hi2A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k17 LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 16A

(Mus musculus) 		PF13516
(LRR_6) 		4 LEU A 386
LEU A 379
THR A 375
MET A 357
 None
 0.87A 5hbsA-4k17A:
undetectable		 5hbsA-4k17A:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lrs 4-HYDROXY-2-OXOVALER
ATE ALDOLASE

(Thermomonospora
curvata) 		PF00682
(HMGL-like)
PF07836
(DmpG_comm) 		4 LEU A 155
LEU A 146
TYR A 171
MET A 162
 None
 1.12A 5hbsA-4lrsA:
undetectable		 5hbsA-4lrsA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n5i ESTERASE/LIPASE

(Lactobacillus
rhamnosus) 		PF07859
(Abhydrolase_3) 		4 LEU X 142
LEU X 154
GLN X  50
MET X 102
 None
 1.08A 5hbsA-4n5iX:
undetectable		 5hbsA-4n5iX:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nkr MOLYBDOPTERIN-GUANIN
E DINUCLEOTIDE
BIOSYNTHESIS PROTEIN
B

(Bacillus
subtilis) 		PF03205
(MobB) 		4 LEU A  31
LEU A  39
THR A 103
TYR A  98
 None
 1.20A 5hbsA-4nkrA:
undetectable		 5hbsA-4nkrA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nmn REPLICATIVE DNA
HELICASE

(Aquifex
aeolicus) 		PF00772
(DnaB)
PF03796
(DnaB_C) 		4 LEU A 272
LEU A 247
THR A 433
TYR A 432
 None
None
ADP  A1001 (-4.7A)
None
 0.95A 5hbsA-4nmnA:
0.9		 5hbsA-4nmnA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ol0 TRANSPORTIN-3

(Homo sapiens) 		PF08389
(Xpo1) 		4 LEU B 143
LEU B 184
THR B 179
TYR B 176
 None
 1.13A 5hbsA-4ol0B:
undetectable		 5hbsA-4ol0B:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p7l POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE

(Escherichia
coli) 		PF14883
(GHL13) 		4 LEU A 650
LEU A 339
TYR A 325
GLN A 330
 None
 0.99A 5hbsA-4p7lA:
undetectable		 5hbsA-4p7lA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pbv NT-3 GROWTH FACTOR
RECEPTOR
PROTEIN-TYROSINE
PHOSPHATASE
CRYPALPHA1 ISOFORM

(Gallus gallus;
Gallus gallus) 		PF00047
(ig)
PF13855
(LRR_8)
PF16920
(TPKR_C2)
PF07679
(I-set)
PF13927
(Ig_3) 		4 LEU A 139
LEU A  94
TRP A 144
GLN C  75
 None
 0.78A 5hbsA-4pbvA:
undetectable		 5hbsA-4pbvA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qgs ALCOHOL
DEHYDROGENASE YQHD

(Escherichia
coli) 		PF00465
(Fe-ADH) 		4 LEU A  90
LEU A  98
THR A 138
TYR A 179
 None
 1.18A 5hbsA-4qgsA:
undetectable		 5hbsA-4qgsA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgy ESTERASE

(uncultured
bacterium FLS12) 		PF00756
(Esterase) 		4 LEU A 193
LEU A 134
THR A  86
GLN A 173
 None
 1.19A 5hbsA-4rgyA:
undetectable		 5hbsA-4rgyA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rlv ANKYRIN-1, ANKYRIN-2

(Homo sapiens;
Mus musculus) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13637
(Ank_4)
PF13857
(Ank_5) 		4 LEU A2182
LEU A2149
THR A2132
TYR A2135
 None
 0.99A 5hbsA-4rlvA:
undetectable		 5hbsA-4rlvA:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rsl FRUCTOSYL PEPTIDE
OXIDASE

(Penicillium
terrenum) 		PF01266
(DAO) 		4 LEU A  63
LEU A 152
THR A 124
GLN A  80
 None
 1.14A 5hbsA-4rslA:
undetectable		 5hbsA-4rslA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ryk LMO0325 PROTEIN

(Listeria
monocytogenes) 		PF01381
(HTH_3) 		4 LEU A 181
LEU A 200
THR A 205
GLN A 247
 None
 1.03A 5hbsA-4rykA:
undetectable		 5hbsA-4rykA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus musculus) 		PF00069
(Pkinase) 		4 LEU B  75
LEU B 167
TYR B 140
GLN B 202
 39G  B 401 (-4.3A)
39G  B 401 (-3.6A)
None
None
 1.19A 5hbsA-4tyhB:
undetectable		 5hbsA-4tyhB:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xai MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TAILLESS
ORTHOLOG

(Escherichia
coli;
Tribolium
castaneum) 		PF00104
(Hormone_recep)
PF13416
(SBP_bac_8) 		4 LEU A1223
LEU A1230
THR A1308
GLN A1337
 None
 1.18A 5hbsA-4xaiA:
undetectable		 5hbsA-4xaiA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yn5 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE

(Bacillus sp.
JAMB750) 		PF02156
(Glyco_hydro_26) 		4 LEU A 185
LEU A 172
TYR A 235
MET A 149
 None
 1.11A 5hbsA-4yn5A:
undetectable		 5hbsA-4yn5A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxk SIALIDASE A

(Streptococcus
pneumoniae) 		PF02973
(Sialidase) 		4 LEU A 170
THR A 193
TYR A 188
GLN A 203
 None
 1.06A 5hbsA-4zxkA:
undetectable		 5hbsA-4zxkA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a29 EXOPOLYGALACTURONATE
LYASE

(Vibrio
vulnificus) 		PF06917
(Pectate_lyase_2) 		4 LEU A 414
LEU A 466
THR A 527
GLN A 477
 None
 1.10A 5hbsA-5a29A:
undetectable		 5hbsA-5a29A:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c6g AGR133CP
SISTER CHROMATID
COHESION PROTEIN 2

(Eremothecium
gossypii;
Eremothecium
gossypii) 		PF10345
(Cohesin_load)
no annotation 		4 LEU B  19
LEU A 584
GLN A 609
MET A 612
 None
 0.99A 5hbsA-5c6gB:
undetectable		 5hbsA-5c6gB:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF

(Serratia sp.
FS14) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		4 LEU A 726
LEU A 640
THR A 668
GLN A  72
 None
 1.20A 5hbsA-5cioA:
undetectable		 5hbsA-5cioA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cz1 INTEGRASE

(Mouse mammary
tumor virus) 		PF00665
(rve) 		4 LEU A 188
LEU A 168
THR A  67
GLN A 154
 None
 1.15A 5hbsA-5cz1A:
1.1		 5hbsA-5cz1A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ee5 BREFELDIN
A-INHIBITED GUANINE
NUCLEOTIDE-EXCHANGE
PROTEIN 1

(Homo sapiens) 		PF16213
(DCB) 		4 LEU A 126
LEU A 103
LYS A   8
TYR A  80
 None
 0.97A 5hbsA-5ee5A:
undetectable		 5hbsA-5ee5A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey8 ACYL-COA SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00501
(AMP-binding) 		4 LEU A 267
LEU A 311
THR A 237
GLN A  86
 None
5SV  A 701 (-4.2A)
5SV  A 701 (-3.3A)
None
 1.18A 5hbsA-5ey8A:
undetectable		 5hbsA-5ey8A:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsw RNA DEPENDENT RNA
POLYMERASE QDE-1

(Thielavia
terrestris) 		PF05183
(RdRP) 		4 LEU A 276
LEU A 396
THR A 301
GLN A 356
 None
 0.94A 5hbsA-5fswA:
undetectable		 5hbsA-5fswA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hsi PUTATIVE
DECARBOXYLASE

(Lactobacillus
brevis) 		PF00282
(Pyridoxal_deC) 		4 LEU A 231
LEU A 175
THR A 200
GLN A 317
 None
 1.14A 5hbsA-5hsiA:
undetectable		 5hbsA-5hsiA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxa ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)

(Paraburkholderia
xenovorans) 		PF00982
(Glyco_transf_20) 		4 LEU A 302
LEU A 279
THR A 367
GLN A 417
 None
 0.82A 5hbsA-5hxaA:
undetectable		 5hbsA-5hxaA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1

(Homo sapiens) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 LEU A1095
LEU A1127
GLN A1422
MET A 868
 None
 1.19A 5hbsA-5iy9A:
undetectable		 5hbsA-5iy9A:
7.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j47 LARGE T ANTIGEN

(Human
polyomavirus 2) 		PF06431
(Polyoma_lg_T_C) 		4 LEU A 627
LEU A 385
THR A 575
GLN A 571
 None
 1.16A 5hbsA-5j47A:
undetectable		 5hbsA-5j47A:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jtf PUTATIVE
PHOSPHINOTHRICIN
N-ACETYLTRANSFERASE

(Pseudomonas
putida) 		PF13420
(Acetyltransf_4) 		4 LEU A 111
LEU A 176
THR A  50
TYR A  70
 None
 1.01A 5hbsA-5jtfA:
undetectable		 5hbsA-5jtfA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l5n PLEXIN-A4

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI)
PF01833
(TIG) 		4 LEU A 444
LEU A 493
THR A 471
GLN A 511
 LEU  A 444 ( 0.5A)
LEU  A 493 ( 0.5A)
THR  A 471 ( 0.8A)
GLN  A 511 ( 0.6A)
 1.19A 5hbsA-5l5nA:
undetectable		 5hbsA-5l5nA:
7.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6u BETA-MANNOSIDASE

(Dictyoglomus
thermophilum) 		PF00703
(Glyco_hydro_2)
PF02837
(Glyco_hydro_2_N) 		5 LEU A 343
LEU A 619
THR A 519
TYR A 616
TRP A 605
 None
 1.38A 5hbsA-5n6uA:
undetectable		 5hbsA-5n6uA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u0s MEDIATOR COMPLEX
SUBUNIT 8
MEDIATOR COMPLEX
SUBUNIT 18

(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe) 		PF10232
(Med8)
PF09637
(Med18) 		4 LEU H 188
LEU R 167
TYR R   5
MET H 195
 None
 1.09A 5hbsA-5u0sH:
undetectable		 5hbsA-5u0sH:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w66 RNA POLYMERASE
I-SPECIFIC
TRANSCRIPTION
INITIATION FACTOR
RRN7

(Saccharomyces
cerevisiae) 		no annotation 4 LEU P 487
THR P 270
TYR P 309
GLN P 250
 None
 1.09A 5hbsA-5w66P:
undetectable		 5hbsA-5w66P:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtc NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
5
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4L

(Homo sapiens;
Homo sapiens;
Homo sapiens) 		no annotation
no annotation
no annotation 		4 LEU i  75
LEU k  46
THR k  51
GLN h  25
 None
 1.20A 5hbsA-5xtci:
undetectable		 5hbsA-5xtci:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtd NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1

(Homo sapiens) 		PF15879
(MWFE) 		4 LEU s 162
LEU s 103
THR s 108
MET s 233
 None
 1.15A 5hbsA-5xtds:
undetectable		 5hbsA-5xtds:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y1a -

(-) 		no annotation 4 LEU A 128
LEU A 250
TYR A 162
GLN A  54
 None
 1.11A 5hbsA-5y1aA:
undetectable		 5hbsA-5y1aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y4d ANKYRIN-1,ANKYRIN-2,
ANKYRIN-2

(Homo sapiens;
Mus musculus) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13637
(Ank_4) 		4 LEU A2182
LEU A2149
THR A2132
TYR A2135
 None
 1.08A 5hbsA-5y4dA:
undetectable		 5hbsA-5y4dA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4

(Pseudoxanthomonas
mexicana) 		no annotation 4 LEU A 622
LEU A 561
THR A 534
TYR A 527
 None
None
None
PRO  A 802 (-4.7A)
 1.18A 5hbsA-5yp3A:
undetectable		 5hbsA-5yp3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bcb RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 18

(Mus musculus) 		no annotation 4 LEU A 363
LEU A 335
THR A 315
TYR A 377
 None
 1.15A 5hbsA-6bcbA:
undetectable		 5hbsA-6bcbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ei3 PROTON-DEPENDENT
OLIGOPEPTIDE
TRANSPORTER FAMILY
PROTEIN

(Xanthomonas
campestris) 		no annotation 4 LEU A 168
LEU A 356
THR A 422
TYR A 418
 78M  A 610 ( 4.6A)
78M  A 613 ( 4.9A)
None
None
 1.08A 5hbsA-6ei3A:
undetectable		 5hbsA-6ei3A:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eu2 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC3

(Saccharomyces
cerevisiae) 		no annotation 4 LEU O  79
LEU O  98
TYR O 121
GLN O 108
 None
 0.91A 5hbsA-6eu2O:
undetectable		 5hbsA-6eu2O:
undetectable