SIMILAR PATTERNS OF AMINO ACIDS FOR 5HBS_A_RTLA201_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c41 LUMAZINE SYNTHASE

(Magnaporthe
grisea) 		PF00885
(DMRL_synthase) 		5 VAL A 119
LEU A 155
ALA A 167
ILE A  51
ILE A 117
 None
 1.17A 5hbsA-1c41A:
undetectable		 5hbsA-1c41A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ejb LUMAZINE SYNTHASE

(Saccharomyces
cerevisiae) 		PF00885
(DMRL_synthase) 		5 VAL A  89
LEU A 125
ALA A 137
ILE A  52
ILE A  87
 None
 1.12A 5hbsA-1ejbA:
undetectable		 5hbsA-1ejbA:
20.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ggl PROTEIN (CELLULAR
RETINOL-BINDING
PROTEIN III)

(Homo sapiens) 		PF00061
(Lipocalin) 		5 TYR A  19
ALA A  33
PRO A  38
SER A  55
LEU A 117
 None
 0.68A 5hbsA-1gglA:
23.2		 5hbsA-1gglA:
53.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ggl PROTEIN (CELLULAR
RETINOL-BINDING
PROTEIN III)

(Homo sapiens) 		PF00061
(Lipocalin) 		5 TYR A  19
ALA A  33
SER A  55
ARG A  58
LEU A 117
 None
 0.77A 5hbsA-1gglA:
23.2		 5hbsA-1gglA:
53.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i74 PROBABLE
MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE

(Streptococcus
mutans) 		PF01368
(DHH)
PF02833
(DHHA2) 		5 TYR A 180
LEU A 153
ALA A 166
ILE A  16
SER A 121
 None
 1.09A 5hbsA-1i74A:
undetectable		 5hbsA-1i74A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j9a OLIGORIBONUCLEASE

(Haemophilus
influenzae) 		PF00929
(RNase_T) 		5 VAL A  51
LEU A  83
ALA A  87
ILE A  12
ILE A  31
 None
 1.20A 5hbsA-1j9aA:
undetectable		 5hbsA-1j9aA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jae ALPHA-AMYLASE

(Tenebrio
molitor) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		5 PHE A   6
VAL A 280
ALA A   4
ILE A  24
LEU A  32
 None
 1.13A 5hbsA-1jaeA:
undetectable		 5hbsA-1jaeA:
12.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jjx BRAIN-TYPE FATTY
ACID BINDING PROTEIN

(Homo sapiens) 		PF00061
(Lipocalin) 		5 PHE A  16
TYR A  19
PRO A  38
ILE A  51
SER A  55
 None
 1.08A 5hbsA-1jjxA:
18.3		 5hbsA-1jjxA:
39.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jjx BRAIN-TYPE FATTY
ACID BINDING PROTEIN

(Homo sapiens) 		PF00061
(Lipocalin) 		5 PHE A  16
TYR A  19
VAL A  25
PRO A  38
ILE A  51
 None
 1.07A 5hbsA-1jjxA:
18.3		 5hbsA-1jjxA:
39.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k32 TRICORN PROTEASE

(Thermoplasma
acidophilum) 		PF03572
(Peptidase_S41)
PF07676
(PD40)
PF14684
(Tricorn_C1)
PF14685
(Tricorn_PDZ) 		5 VAL A 191
LEU A 184
ILE A 248
ILE A 213
LEU A 264
 None
 1.15A 5hbsA-1k32A:
undetectable		 5hbsA-1k32A:
8.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kz1 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE

(Schizosaccharomyces
pombe) 		PF00885
(DMRL_synthase) 		5 VAL A  86
LEU A 122
ALA A 134
ILE A  54
ILE A  84
 None
 1.18A 5hbsA-1kz1A:
undetectable		 5hbsA-1kz1A:
20.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lpj RETINOL-BINDING
PROTEIN IV, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		8 PHE A  16
TYR A  19
ALA A  33
PRO A  38
ILE A  51
SER A  55
ARG A  58
LEU A 117
 None
 0.71A 5hbsA-1lpjA:
23.8		 5hbsA-1lpjA:
55.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mx8 CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO

(Rattus
norvegicus) 		PF00061
(Lipocalin) 		8 PHE A  16
TYR A  19
ALA A  33
ILE A  51
SER A  55
ARG A  58
MET A  62
ILE A  77
 RTL  A 135 ( 4.6A)
None
RTL  A 135 ( 3.9A)
RTL  A 135 ( 4.6A)
RTL  A 135 ( 4.4A)
None
RTL  A 135 (-2.9A)
RTL  A 135 (-3.5A)
 0.92A 5hbsA-1mx8A:
19.9		 5hbsA-1mx8A:
92.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mx8 CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO

(Rattus
norvegicus) 		PF00061
(Lipocalin) 		8 PHE A  16
TYR A  19
ALA A  33
PRO A  38
ILE A  51
ARG A  58
MET A  62
ILE A  77
 RTL  A 135 ( 4.6A)
None
RTL  A 135 ( 3.9A)
RTL  A 135 ( 4.4A)
RTL  A 135 ( 4.6A)
None
RTL  A 135 (-2.9A)
RTL  A 135 (-3.5A)
 0.95A 5hbsA-1mx8A:
19.9		 5hbsA-1mx8A:
92.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mx8 CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO

(Rattus
norvegicus) 		PF00061
(Lipocalin) 		8 PHE A  16
TYR A  19
LEU A  29
ALA A  33
ILE A  51
SER A  55
MET A  62
ILE A  77
 RTL  A 135 ( 4.6A)
None
RTL  A 135 (-3.8A)
RTL  A 135 ( 3.9A)
RTL  A 135 ( 4.6A)
RTL  A 135 ( 4.4A)
RTL  A 135 (-2.9A)
RTL  A 135 (-3.5A)
 0.92A 5hbsA-1mx8A:
19.9		 5hbsA-1mx8A:
92.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mx8 CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO

(Rattus
norvegicus) 		PF00061
(Lipocalin) 		8 PHE A  16
TYR A  19
LEU A  29
ALA A  33
PRO A  38
ILE A  51
MET A  62
ILE A  77
 RTL  A 135 ( 4.6A)
None
RTL  A 135 (-3.8A)
RTL  A 135 ( 3.9A)
RTL  A 135 ( 4.4A)
RTL  A 135 ( 4.6A)
RTL  A 135 (-2.9A)
RTL  A 135 (-3.5A)
 0.96A 5hbsA-1mx8A:
19.9		 5hbsA-1mx8A:
92.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mx8 CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO

(Rattus
norvegicus) 		PF00061
(Lipocalin) 		8 PHE A  16
TYR A  19
VAL A  25
LEU A  29
ALA A  33
ILE A  51
SER A  55
ILE A  77
 RTL  A 135 ( 4.6A)
None
None
RTL  A 135 (-3.8A)
RTL  A 135 ( 3.9A)
RTL  A 135 ( 4.6A)
RTL  A 135 ( 4.4A)
RTL  A 135 (-3.5A)
 0.86A 5hbsA-1mx8A:
19.9		 5hbsA-1mx8A:
92.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mx8 CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO

(Rattus
norvegicus) 		PF00061
(Lipocalin) 		8 PHE A  16
TYR A  19
VAL A  25
LEU A  29
ALA A  33
PRO A  38
ILE A  51
ILE A  77
 RTL  A 135 ( 4.6A)
None
None
RTL  A 135 (-3.8A)
RTL  A 135 ( 3.9A)
RTL  A 135 ( 4.4A)
RTL  A 135 ( 4.6A)
RTL  A 135 (-3.5A)
 0.88A 5hbsA-1mx8A:
19.9		 5hbsA-1mx8A:
92.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mx8 CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO

(Rattus
norvegicus) 		PF00061
(Lipocalin) 		6 VAL A  25
LEU A  29
ALA A  33
PRO A  38
ILE A  61
ILE A  77
 None
RTL  A 135 (-3.8A)
RTL  A 135 ( 3.9A)
RTL  A 135 ( 4.4A)
None
RTL  A 135 (-3.5A)
 1.33A 5hbsA-1mx8A:
19.9		 5hbsA-1mx8A:
92.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pmp P2 MYELIN PROTEIN

(Bos taurus) 		PF00061
(Lipocalin) 		5 PHE A  16
TYR A  19
VAL A  25
ILE A  51
SER A  55
 OLA  A 200 ( 4.8A)
None
None
None
OLA  A 200 ( 4.3A)
 0.71A 5hbsA-1pmpA:
19.9		 5hbsA-1pmpA:
40.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pmp P2 MYELIN PROTEIN

(Bos taurus) 		PF00061
(Lipocalin) 		5 PHE A  16
VAL A  25
PRO A  38
ILE A  51
SER A  55
 OLA  A 200 ( 4.8A)
None
None
None
OLA  A 200 ( 4.3A)
 0.77A 5hbsA-1pmpA:
19.9		 5hbsA-1pmpA:
40.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q2l PROTEASE III

(Escherichia
coli) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF16187
(Peptidase_M16_M) 		5 VAL A 333
ILE A 311
ARG A 318
ILE A 336
LEU A 376
 None
 0.93A 5hbsA-1q2lA:
undetectable		 5hbsA-1q2lA:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r20 ULTRASPIRACLE
PROTEIN
ECDYSONE RECEPTOR

(Heliothis
virescens;
Heliothis
virescens) 		PF00104
(Hormone_recep)
PF00104
(Hormone_recep) 		5 PHE D 487
LEU A 419
ALA A 415
ILE D 298
ILE D 443
 None
 1.10A 5hbsA-1r20D:
undetectable		 5hbsA-1r20D:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rw9 CHONDROITIN AC LYASE

(Paenarthrobacter
aurescens) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		5 VAL A 359
LEU A 362
ILE A 285
ILE A 313
LEU A 431
 None
 1.18A 5hbsA-1rw9A:
undetectable		 5hbsA-1rw9A:
10.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tow FATTY ACID-BINDING
PROTEIN, ADIPOCYTE

(Homo sapiens) 		PF00061
(Lipocalin) 		6 PHE A  16
TYR A  19
VAL A  25
ALA A  33
ILE A  51
SER A  55
 CRZ  A 501 (-4.5A)
None
None
CRZ  A 501 ( 4.1A)
None
CRZ  A 501 ( 4.8A)
 0.89A 5hbsA-1towA:
20.2		 5hbsA-1towA:
35.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tow FATTY ACID-BINDING
PROTEIN, ADIPOCYTE

(Homo sapiens) 		PF00061
(Lipocalin) 		6 TYR A  19
VAL A  25
ALA A  33
PRO A  38
ILE A  51
SER A  55
 None
None
CRZ  A 501 ( 4.1A)
CRZ  A 501 (-4.5A)
None
CRZ  A 501 ( 4.8A)
 0.96A 5hbsA-1towA:
20.2		 5hbsA-1towA:
35.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2x ADP-SPECIFIC
PHOSPHOFRUCTOKINASE

(Pyrococcus
horikoshii) 		PF04587
(ADP_PFK_GK) 		5 VAL A 451
LEU A 449
ILE A 169
ILE A 122
LEU A 146
 None
 1.18A 5hbsA-1u2xA:
undetectable		 5hbsA-1u2xA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x2g LIPOATE-PROTEIN
LIGASE A

(Escherichia
coli) 		PF03099
(BPL_LplA_LipB)
PF10437
(Lip_prot_lig_C) 		5 VAL A 184
LEU A 153
ALA A 156
ILE A  45
LEU A 165
 None
 1.20A 5hbsA-1x2gA:
undetectable		 5hbsA-1x2gA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfi UNKNOWN PROTEIN

(Arabidopsis
thaliana) 		PF01937
(DUF89) 		5 TYR A  21
VAL A 301
LEU A 305
ILE A 324
ILE A 296
 None
 1.08A 5hbsA-1xfiA:
undetectable		 5hbsA-1xfiA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2erc RRNA METHYL
TRANSFERASE

(Bacillus
subtilis) 		PF00398
(RrnaAD) 		5 PHE A 163
TYR A 162
PRO A 103
ILE A 154
ILE A  22
 None
 1.20A 5hbsA-2ercA:
undetectable		 5hbsA-2ercA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fuv PHOSPHOGLUCOMUTASE

(Salmonella
enterica) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 VAL A 359
LEU A 362
ILE A 413
MET A 414
ILE A 329
 None
 1.10A 5hbsA-2fuvA:
undetectable		 5hbsA-2fuvA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fuv PHOSPHOGLUCOMUTASE

(Salmonella
enterica) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 VAL A 359
LEU A 362
MET A 414
ILE A 329
LEU A 380
 None
 1.18A 5hbsA-2fuvA:
undetectable		 5hbsA-2fuvA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3e DIAMINOPIMELATE
DECARBOXYLASE

(Aquifex
aeolicus) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		5 LEU A  79
ALA A  81
PRO A 280
ILE A 247
ILE A  44
 None
 1.10A 5hbsA-2p3eA:
undetectable		 5hbsA-2p3eA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbi GUANINE
NUCLEOTIDE-BINDING
PROTEIN SUBUNIT BETA
5

(Mus musculus) 		PF00400
(WD40) 		5 PHE B 299
VAL B 318
LEU B  48
SER B 294
ARG B 296
 None
None
GOL  A 905 ( 3.4A)
None
None
 1.12A 5hbsA-2pbiB:
undetectable		 5hbsA-2pbiB:
17.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q9s FATTY ACID-BINDING
PROTEIN

(Mus musculus) 		PF00061
(Lipocalin) 		6 PHE A  16
TYR A  19
VAL A  25
ALA A  33
ILE A  51
SER A  55
 None
None
None
EIC  A 601 (-3.5A)
None
None
 0.83A 5hbsA-2q9sA:
20.0		 5hbsA-2q9sA:
31.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q9s FATTY ACID-BINDING
PROTEIN

(Mus musculus) 		PF00061
(Lipocalin) 		6 PHE A  16
VAL A  25
ALA A  33
PRO A  38
ILE A  51
SER A  55
 None
None
EIC  A 601 (-3.5A)
EIC  A 601 (-4.6A)
None
None
 0.88A 5hbsA-2q9sA:
20.0		 5hbsA-2q9sA:
31.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ql3 PROBABLE
TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY PROTEIN

(Rhodococcus
jostii) 		PF03466
(LysR_substrate) 		5 PHE A 234
LEU A 111
ALA A 110
ILE A 270
SER A 210
 None
 1.20A 5hbsA-2ql3A:
undetectable		 5hbsA-2ql3A:
21.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rcq RETINOL-BINDING
PROTEIN II, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		6 PHE A  16
TYR A  19
ALA A  33
SER A  55
ARG A  58
LEU A 117
 None
None
None
None
SO4  A 152 (-3.1A)
None
 0.80A 5hbsA-2rcqA:
24.0		 5hbsA-2rcqA:
51.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtz UDP-N-ACETYLMURAMOYL
-L-ALANYL-D-GLUTAMAT
E--2,6-DIAMINOPIMELA
TE LIGASE

(Mycobacterium
tuberculosis) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 VAL A 164
LEU A 168
ALA A 175
ILE A 149
LEU A 202
 None
 1.09A 5hbsA-2wtzA:
undetectable		 5hbsA-2wtzA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z0s PROBABLE EXOSOME
COMPLEX RNA-BINDING
PROTEIN 1

(Aeropyrum
pernix) 		PF15985
(KH_6) 		5 TYR A 120
VAL A  84
LEU A 136
ALA A 123
ILE A 154
 None
 1.19A 5hbsA-2z0sA:
undetectable		 5hbsA-2z0sA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3y O-METHYLTRANSFERASE

(Mesembryanthemum
crystallinum) 		PF01596
(Methyltransf_3) 		5 VAL A  65
LEU A  66
MET A 168
ILE A 176
LEU A 213
 None
 1.19A 5hbsA-3c3yA:
undetectable		 5hbsA-3c3yA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgx PUTATIVE
NUCLEOTIDE-DIPHOSPHO
-SUGAR TRANSFERASE

(Desulfovibrio
alaskensis) 		PF09837
(DUF2064) 		5 TYR A  35
VAL A 191
LEU A 200
SER A 212
LEU A  72
 IMD  A 242 (-3.8A)
None
None
None
None
 1.18A 5hbsA-3cgxA:
undetectable		 5hbsA-3cgxA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ed4 ARYLSULFATASE

(Escherichia
coli) 		PF00884
(Sulfatase) 		5 VAL A  79
ILE A 128
SER A 403
ILE A 360
LEU A  98
 None
 1.20A 5hbsA-3ed4A:
undetectable		 5hbsA-3ed4A:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ek5 URIDYLATE KINASE

(Xanthomonas
campestris) 		PF00696
(AA_kinase) 		5 LEU A   4
ALA A  44
ILE A 130
ILE A   9
LEU A  34
 None
 0.92A 5hbsA-3ek5A:
undetectable		 5hbsA-3ek5A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hur ALANINE RACEMASE

(Oenococcus oeni) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 LEU A 365
ALA A 366
ILE A 311
ARG A 296
LEU A 285
 None
SO4  A 396 ( 4.5A)
None
None
None
 1.05A 5hbsA-3hurA:
undetectable		 5hbsA-3hurA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I)
PF01590
(GAF)
PF13185
(GAF_2) 		5 PHE A 404
LEU A 396
ALA A 400
ILE A 515
ILE A 542
 None
 1.09A 5hbsA-3ibjA:
undetectable		 5hbsA-3ibjA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kg9 CURK

(Lyngbya
majuscula) 		PF14765
(PS-DH) 		5 PHE A1004
VAL A1048
PRO A1165
ILE A1194
ILE A1064
 None
 1.18A 5hbsA-3kg9A:
2.4		 5hbsA-3kg9A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l09 PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Jannaschia sp.
CCS1) 		PF07848
(PaaX) 		5 PHE A 203
LEU A  47
ILE A 102
SER A  35
LEU A 245
 None
 1.10A 5hbsA-3l09A:
undetectable		 5hbsA-3l09A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7z PROBABLE EXOSOME
COMPLEX RNA-BINDING
PROTEIN 1

(Sulfolobus
solfataricus) 		no annotation 5 TYR C 125
VAL C  90
LEU C 141
ALA C 128
ILE C 159
 None
 1.15A 5hbsA-3l7zC:
undetectable		 5hbsA-3l7zC:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lfv CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF01590
(GAF) 		5 PHE A 341
LEU A 333
ALA A 337
ILE A 465
ILE A 497
 None
 1.20A 5hbsA-3lfvA:
undetectable		 5hbsA-3lfvA:
15.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3nr3 PMP2 PROTEIN

(Homo sapiens) 		PF00061
(Lipocalin) 		6 PHE A  17
TYR A  20
VAL A  26
PRO A  39
ILE A  52
SER A  56
 None
None
None
SO4  A 903 ( 4.8A)
None
PLM  A 901 (-3.7A)
 0.62A 5hbsA-3nr3A:
19.8		 5hbsA-3nr3A:
34.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o1k DIHYDRONEOPTERIN
ALDOLASE FOLB,
PUTATIVE

(Vibrio cholerae) 		PF02152
(FolB) 		5 VAL A 101
LEU A  63
ILE A  76
ILE A  95
LEU A 108
 None
 1.20A 5hbsA-3o1kA:
undetectable		 5hbsA-3o1kA:
20.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pp6 SODIUM-CALCIUM
EXCHANGER

(Doryteuthis
pealeii) 		PF00061
(Lipocalin) 		6 PHE A  17
TYR A  20
VAL A  26
ALA A  34
PRO A  39
ILE A  52
 None
None
None
PAM  A 133 ( 3.7A)
PAM  A 133 (-4.4A)
None
 0.73A 5hbsA-3pp6A:
21.0		 5hbsA-3pp6A:
36.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppb PUTATIVE TETR FAMILY
TRANSCRIPTION
REGULATOR

(Shewanella
loihica) 		PF00440
(TetR_N) 		5 PHE A 187
LEU A  81
ALA A  85
MET A 124
ILE A 135
 PG4  A 216 (-4.7A)
None
PG4  A 216 ( 4.1A)
None
None
 1.12A 5hbsA-3ppbA:
undetectable		 5hbsA-3ppbA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sx2 PUTATIVE
3-KETOACYL-(ACYL-CAR
RIER-PROTEIN)
REDUCTASE

(Mycobacterium
avium) 		PF13561
(adh_short_C2) 		5 VAL A 152
ALA A 250
ILE A 211
MET A 210
ILE A 154
 None
None
NAD  A 300 (-3.8A)
NAD  A 300 (-3.7A)
NAD  A 300 (-4.7A)
 1.20A 5hbsA-3sx2A:
undetectable		 5hbsA-3sx2A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vcy UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Aliivibrio
fischeri) 		PF00275
(EPSP_synthase) 		5 LEU A 371
ALA A 375
ILE A 281
ILE A 234
LEU A 267
 None
 0.97A 5hbsA-3vcyA:
undetectable		 5hbsA-3vcyA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vla EDGP

(Daucus carota) 		PF14541
(TAXi_C)
PF14543
(TAXi_N) 		5 VAL A 241
LEU A 258
SER A 282
ILE A 244
LEU A 359
 None
 0.97A 5hbsA-3vlaA:
undetectable		 5hbsA-3vlaA:
15.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wbg FATTY ACID-BINDING
PROTEIN, HEART

(Homo sapiens) 		PF00061
(Lipocalin) 		7 PHE A  16
TYR A  19
VAL A  25
ALA A  33
PRO A  38
SER A  55
LEU A 115
 2AN  A 201 ( 4.9A)
2AN  A 201 (-4.8A)
None
2AN  A 201 (-3.8A)
2AN  A 201 ( 4.3A)
2AN  A 201 (-3.2A)
None
 0.81A 5hbsA-3wbgA:
20.3		 5hbsA-3wbgA:
35.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zh4 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Streptococcus
pneumoniae) 		PF00275
(EPSP_synthase) 		5 LEU A 371
ALA A 375
ILE A 282
ILE A 235
LEU A 268
 FLC  A1419 (-4.0A)
None
None
None
None
 1.15A 5hbsA-3zh4A:
undetectable		 5hbsA-3zh4A:
12.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4a60 FATTY ACID-BINDING
PROTEIN 9 TESTIS
LIPID-BINDING
PROTEIN, TLBP,
TESTIS-TYPE FATTY
ACID-BINDING
PROTEIN, T-FABP

(Homo sapiens) 		PF00061
(Lipocalin) 		7 PHE A  17
TYR A  20
VAL A  26
ALA A  34
PRO A  39
ILE A  52
SER A  56
 None
None
None
NA  A1132 ( 4.0A)
None
None
NA  A1132 (-2.9A)
 0.63A 5hbsA-4a60A:
19.0		 5hbsA-4a60A:
30.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4azp FATTY ACID-BINDING
PROTEIN, EPIDERMAL

(Mus musculus) 		PF00061
(Lipocalin) 		5 PHE A  19
TYR A  22
VAL A  28
ALA A  36
SER A  58
 None
None
None
A9M  A1136 (-3.4A)
A9M  A1136 ( 4.1A)
 0.77A 5hbsA-4azpA:
20.6		 5hbsA-4azpA:
33.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4azp FATTY ACID-BINDING
PROTEIN, EPIDERMAL

(Mus musculus) 		PF00061
(Lipocalin) 		5 TYR A  22
VAL A  28
LEU A  32
ALA A  36
SER A  58
 None
None
A9M  A1136 ( 4.1A)
A9M  A1136 (-3.4A)
A9M  A1136 ( 4.1A)
 0.87A 5hbsA-4azpA:
20.6		 5hbsA-4azpA:
33.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bf7 ARABINOGALACTAN
ENDO-1,4-BETA-GALACT
OSIDASE A

(Aspergillus
nidulans) 		PF07745
(Glyco_hydro_53) 		6 TYR A 294
VAL A  41
LEU A  36
ILE A  48
SER A  11
ILE A  44
 None
 1.38A 5hbsA-4bf7A:
undetectable		 5hbsA-4bf7A:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c2l ENDO-XYLOGALACTURONA
N HYDROLASE A

(Aspergillus
tubingensis) 		PF00295
(Glyco_hydro_28) 		5 VAL A 271
ALA A 283
SER A 279
MET A 193
ILE A 245
 None
 1.20A 5hbsA-4c2lA:
undetectable		 5hbsA-4c2lA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cp6 CHOLINE BINDING
PROTEIN PCPA

(Streptococcus
pneumoniae) 		PF13306
(LRR_5) 		5 VAL A 101
PRO A 172
ILE A 203
SER A 174
LEU A 192
 None
 1.11A 5hbsA-4cp6A:
undetectable		 5hbsA-4cp6A:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e51 HISTIDINE--TRNA
LIGASE

(Burkholderia
thailandensis) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		5 VAL A 255
LEU A 250
ALA A 149
MET A 313
LEU A  39
 None
 1.14A 5hbsA-4e51A:
undetectable		 5hbsA-4e51A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f9o HEXOKINASE-1

(Homo sapiens) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		5 VAL A 678
LEU A 864
ILE A 721
ILE A 745
LEU A 484
 None
 1.03A 5hbsA-4f9oA:
undetectable		 5hbsA-4f9oA:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h0c PHOSPHOLIPASE/CARBOX
YLESTERASE

(Dyadobacter
fermentans) 		PF02230
(Abhydrolase_2) 		5 VAL A  68
ALA A 138
ILE A 153
ARG A 117
ILE A 133
 None
 1.07A 5hbsA-4h0cA:
undetectable		 5hbsA-4h0cA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h5u PROBABLE HYDROLASE
NIT2

(Saccharomyces
cerevisiae) 		PF00795
(CN_hydrolase) 		5 VAL A  26
LEU A  13
ALA A  11
ILE A 157
ILE A  90
 None
 1.14A 5hbsA-4h5uA:
undetectable		 5hbsA-4h5uA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hb4 EXPORTIN-1

(Saccharomyces
cerevisiae) 		PF03810
(IBN_N)
PF08389
(Xpo1)
PF08767
(CRM1_C) 		5 LEU C 791
ALA C 794
ILE C 679
ILE C 766
LEU C 690
 None
 1.16A 5hbsA-4hb4C:
undetectable		 5hbsA-4hb4C:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		5 ALA A 384
ILE A 392
SER A 387
ILE A 331
LEU A 415
 None
 1.19A 5hbsA-4hq1A:
undetectable		 5hbsA-4hq1A:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpo NUCLEOSIDE
N-RIBOHYDROLASE 3

(Zea mays) 		PF01156
(IU_nuc_hydro) 		5 VAL A 177
LEU A 126
ALA A 122
SER A 243
ILE A 184
 None
 1.15A 5hbsA-4kpoA:
undetectable		 5hbsA-4kpoA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kq6 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE

([Candida]
glabrata) 		PF00885
(DMRL_synthase) 		5 VAL A  90
LEU A 126
ALA A 138
ILE A  53
ILE A  88
 None
 1.12A 5hbsA-4kq6A:
undetectable		 5hbsA-4kq6A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4my2 MALTOSE-BINDING
PERIPLASMIC PROTEIN,
NORRIN FUSION
PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF00007
(Cys_knot)
PF13416
(SBP_bac_8) 		5 VAL A 185
LEU A 363
ALA A 348
ILE A 228
ILE A 163
 None
 1.08A 5hbsA-4my2A:
undetectable		 5hbsA-4my2A:
16.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nns FATTY ACID-BINDING
PROTEIN, ADIPOCYTE

(Homo sapiens) 		PF00061
(Lipocalin) 		6 PHE A  16
TYR A  19
VAL A  25
ALA A  33
ILE A  51
SER A  55
 None
None
None
75D  A 201 ( 4.1A)
None
75D  A 201 ( 4.7A)
 0.89A 5hbsA-4nnsA:
19.8		 5hbsA-4nnsA:
31.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nns FATTY ACID-BINDING
PROTEIN, ADIPOCYTE

(Homo sapiens) 		PF00061
(Lipocalin) 		6 TYR A  19
VAL A  25
ALA A  33
PRO A  38
ILE A  51
SER A  55
 None
None
75D  A 201 ( 4.1A)
75D  A 201 (-4.4A)
None
75D  A 201 ( 4.7A)
 0.93A 5hbsA-4nnsA:
19.8		 5hbsA-4nnsA:
31.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4okr MICRONEMAL PROTEIN
MIC2

(Toxoplasma
gondii) 		PF00090
(TSP_1)
PF00092
(VWA) 		5 PHE A  98
LEU A 245
ALA A 255
ILE A 108
ILE A 184
 None
 0.88A 5hbsA-4okrA:
undetectable		 5hbsA-4okrA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oku MICRONEMAL PROTEIN
MIC2

(Toxoplasma
gondii) 		PF00090
(TSP_1)
PF00092
(VWA) 		5 PHE A  98
LEU A 245
ALA A 255
ILE A 108
ILE A 184
 None
 0.90A 5hbsA-4okuA:
undetectable		 5hbsA-4okuA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozt ECDYSONE RECEPTOR
RETINOID X RECEPTOR

(Pediculus
humanus;
Pediculus
humanus) 		PF00104
(Hormone_recep)
PF00104
(Hormone_recep) 		5 PHE E 477
LEU U 353
ALA U 349
ILE E 292
ILE E 435
 None
 1.05A 5hbsA-4oztE:
undetectable		 5hbsA-4oztE:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q0c VIRULENCE SENSOR
PROTEIN BVGS

(Bordetella
pertussis) 		PF00497
(SBP_bac_3) 		5 PHE A 375
VAL A 356
LEU A 314
ILE A 397
SER A 465
 None
 1.15A 5hbsA-4q0cA:
undetectable		 5hbsA-4q0cA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qp0 ENDO-BETA-MANNANASE

(Rhizomucor
miehei) 		PF00150
(Cellulase) 		5 PHE A  12
VAL A  51
ALA A 320
ILE A 172
ILE A 104
 None
 1.15A 5hbsA-4qp0A:
undetectable		 5hbsA-4qp0A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7u UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Vibrio cholerae) 		PF00275
(EPSP_synthase) 		5 LEU A 371
ALA A 375
ILE A 281
ILE A 234
LEU A 267
 None
 1.03A 5hbsA-4r7uA:
undetectable		 5hbsA-4r7uA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rrp ANTIGEN ASF1P

(Saccharomyces
cerevisiae) 		PF04729
(ASF1_hist_chap) 		5 VAL M 130
ALA M  81
PRO M  79
ILE M 139
ILE M 135
 None
 1.13A 5hbsA-4rrpM:
undetectable		 5hbsA-4rrpM:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wrn MALTOSE-BINDING
PERIPLASMIC
PROTEIN,UROMODULIN

(Escherichia
coli;
Homo sapiens) 		PF00100
(Zona_pellucida)
PF13416
(SBP_bac_8) 		5 VAL A 207
LEU A 385
ALA A 370
ILE A 250
ILE A 185
 None
 1.12A 5hbsA-4wrnA:
undetectable		 5hbsA-4wrnA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 5 VAL B 190
ALA B 156
SER B 173
ARG B 153
LEU B 214
 None
 1.20A 5hbsA-4xeyB:
undetectable		 5hbsA-4xeyB:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7r COENZYME PQQ
SYNTHESIS PROTEIN B

(Methylobacterium
extorquens) 		PF12706
(Lactamase_B_2) 		5 TYR A 192
VAL A   3
LEU A 297
ALA A 212
ILE A   5
 None
 1.02A 5hbsA-4z7rA:
undetectable		 5hbsA-4z7rA:
19.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5b29 FATTY ACID-BINDING
PROTEIN, HEART

(Homo sapiens) 		PF00061
(Lipocalin) 		6 TYR A  19
VAL A  25
ALA A  33
PRO A  38
SER A  55
LEU A 115
 None
None
PLM  A 200 ( 3.7A)
PLM  A 200 ( 4.9A)
PLM  A 200 ( 4.1A)
None
 0.83A 5hbsA-5b29A:
20.5		 5hbsA-5b29A:
34.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5bvq FATTY ACID-BINDING
PROTEIN

(Pygoscelis
papua) 		PF00061
(Lipocalin) 		5 PHE A  17
TYR A  20
VAL A  26
ALA A  34
ILE A  52
 None
 0.75A 5hbsA-5bvqA:
19.6		 5hbsA-5bvqA:
37.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5crj TRANSCRIPTION
TERMINATION FACTOR
1, MITOCHONDRIAL

(Homo sapiens) 		PF02536
(mTERF) 		5 VAL O 150
LEU O 197
ILE O 121
SER O 163
ILE O 156
 None
 1.13A 5hbsA-5crjO:
undetectable		 5hbsA-5crjO:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csc CITRATE SYNTHASE

(Gallus gallus) 		PF00285
(Citrate_synt) 		5 LEU B 403
ALA B 402
ILE B 200
MET B 216
LEU B 120
 None
 1.01A 5hbsA-5cscB:
undetectable		 5hbsA-5cscB:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL

(Homo sapiens) 		PF00117
(GATase)
PF00988
(CPSase_sm_chain)
PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		5 VAL A 422
LEU A 743
ALA A 742
ILE A 487
MET A 462
 None
 1.11A 5hbsA-5dotA:
undetectable		 5hbsA-5dotA:
7.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gkb FATTY ACID BINDIN
PROTEIN, ISOFORM B

(Drosophila
melanogaster) 		PF00061
(Lipocalin) 		5 PHE A  16
TYR A  19
VAL A  25
PRO A  38
SER A  55
 None
 0.70A 5hbsA-5gkbA:
19.6		 5hbsA-5gkbA:
35.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hz5 FATTY ACID-BINDING
PROTEIN, EPIDERMAL

(Homo sapiens) 		PF00061
(Lipocalin) 		5 PHE A  19
TYR A  22
VAL A  28
LEU A  32
ILE A  54
 65X  A 203 ( 4.7A)
65X  A 203 ( 4.7A)
None
65X  A 203 (-3.6A)
None
 0.81A 5hbsA-5hz5A:
20.7		 5hbsA-5hz5A:
31.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8s CAMP-DEPENDENT
PROTEIN KINASE
REGULATORY SUBUNIT

(Plasmodium
falciparum) 		PF00027
(cNMP_binding) 		5 PHE A 349
TYR A 374
VAL A 310
LEU A 307
LEU A 381
 None
 1.20A 5hbsA-5k8sA:
undetectable		 5hbsA-5k8sA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5knm CDNA FLJ39643 FIS,
CLONE SMINT2004023,
HIGHLY SIMILAR TO
HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, ALPHACHAIN
F
BETA-2-MICROGLOBULIN

(Homo sapiens;
Homo sapiens) 		PF00129
(MHC_I)
PF07654
(C1-set)
PF07654
(C1-set) 		5 TYR B  66
VAL B  82
ILE A  23
SER B  61
ILE B  35
 None
 1.07A 5hbsA-5knmB:
undetectable		 5hbsA-5knmB:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrr LYTIC ENDOPEPTIDASE
PREPROENZYME

(Lysobacter sp.
XL1) 		no annotation 5 LEU A 196
ALA A 155
SER A 147
ILE A 188
LEU A 132
 None
 1.19A 5hbsA-5mrrA:
undetectable		 5hbsA-5mrrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wbf METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER (TLPC)

(Helicobacter
pylori) 		no annotation 5 PHE A  93
LEU A 167
ALA A  67
ILE A  56
ILE A 165
 None
 1.20A 5hbsA-5wbfA:
undetectable		 5hbsA-5wbfA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbq PEROXIREDOXIN

(Pyrococcus
horikoshii) 		no annotation 5 VAL A 153
LEU A 152
ALA A 134
ILE A  98
LEU A  22
 None
 1.13A 5hbsA-5xbqA:
undetectable		 5hbsA-5xbqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yim SDEA

(Legionella
pneumophila) 		no annotation 5 PHE A 965
TYR A 962
PRO A 997
SER A 998
LEU A 946
 None
 1.19A 5hbsA-5yimA:
undetectable		 5hbsA-5yimA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evg MULTI-COPPER OXIDASE
CUEO

(Ochrobactrum) 		no annotation 5 PHE A 301
VAL A 272
LEU A 243
ILE A 204
ILE A 224
 None
 1.19A 5hbsA-6evgA:
undetectable		 5hbsA-6evgA:
undetectable