SIMILAR PATTERNS OF AMINO ACIDS FOR 5HBS_A_RTLA201

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c41 LUMAZINE SYNTHASE

(Magnaporthe
grisea) 		PF00885
(DMRL_synthase) 		5 VAL A 119
LEU A 155
ALA A 167
ILE A  51
ILE A 117
 None
 1.17A 5hbsA-1c41A:
undetectable		 5hbsA-1c41A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ejb LUMAZINE SYNTHASE

(Saccharomyces
cerevisiae) 		PF00885
(DMRL_synthase) 		5 VAL A  89
LEU A 125
ALA A 137
ILE A  52
ILE A  87
 None
 1.12A 5hbsA-1ejbA:
undetectable		 5hbsA-1ejbA:
20.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ggl PROTEIN (CELLULAR
RETINOL-BINDING
PROTEIN III)

(Homo sapiens) 		PF00061
(Lipocalin) 		5 TYR A  19
ALA A  33
PRO A  38
SER A  55
LEU A 117
 None
 0.68A 5hbsA-1gglA:
23.2		 5hbsA-1gglA:
53.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ggl PROTEIN (CELLULAR
RETINOL-BINDING
PROTEIN III)

(Homo sapiens) 		PF00061
(Lipocalin) 		5 TYR A  19
ALA A  33
SER A  55
ARG A  58
LEU A 117
 None
 0.77A 5hbsA-1gglA:
23.2		 5hbsA-1gglA:
53.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i74 PROBABLE
MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE

(Streptococcus
mutans) 		PF01368
(DHH)
PF02833
(DHHA2) 		5 TYR A 180
LEU A 153
ALA A 166
ILE A  16
SER A 121
 None
 1.09A 5hbsA-1i74A:
undetectable		 5hbsA-1i74A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j9a OLIGORIBONUCLEASE

(Haemophilus
influenzae) 		PF00929
(RNase_T) 		5 VAL A  51
LEU A  83
ALA A  87
ILE A  12
ILE A  31
 None
 1.20A 5hbsA-1j9aA:
undetectable		 5hbsA-1j9aA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jae ALPHA-AMYLASE

(Tenebrio
molitor) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		5 PHE A   6
VAL A 280
ALA A   4
ILE A  24
LEU A  32
 None
 1.13A 5hbsA-1jaeA:
undetectable		 5hbsA-1jaeA:
12.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jjx BRAIN-TYPE FATTY
ACID BINDING PROTEIN

(Homo sapiens) 		PF00061
(Lipocalin) 		5 PHE A  16
TYR A  19
PRO A  38
ILE A  51
SER A  55
 None
 1.08A 5hbsA-1jjxA:
18.3		 5hbsA-1jjxA:
39.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jjx BRAIN-TYPE FATTY
ACID BINDING PROTEIN

(Homo sapiens) 		PF00061
(Lipocalin) 		5 PHE A  16
TYR A  19
VAL A  25
PRO A  38
ILE A  51
 None
 1.07A 5hbsA-1jjxA:
18.3		 5hbsA-1jjxA:
39.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k32 TRICORN PROTEASE

(Thermoplasma
acidophilum) 		PF03572
(Peptidase_S41)
PF07676
(PD40)
PF14684
(Tricorn_C1)
PF14685
(Tricorn_PDZ) 		5 VAL A 191
LEU A 184
ILE A 248
ILE A 213
LEU A 264
 None
 1.15A 5hbsA-1k32A:
undetectable		 5hbsA-1k32A:
8.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kz1 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE

(Schizosaccharomyces
pombe) 		PF00885
(DMRL_synthase) 		5 VAL A  86
LEU A 122
ALA A 134
ILE A  54
ILE A  84
 None
 1.18A 5hbsA-1kz1A:
undetectable		 5hbsA-1kz1A:
20.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lpj RETINOL-BINDING
PROTEIN IV, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		8 PHE A  16
TYR A  19
ALA A  33
PRO A  38
ILE A  51
SER A  55
ARG A  58
LEU A 117
 None
 0.71A 5hbsA-1lpjA:
23.8		 5hbsA-1lpjA:
55.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mx8 CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO

(Rattus
norvegicus) 		PF00061
(Lipocalin) 		8 PHE A  16
TYR A  19
ALA A  33
ILE A  51
SER A  55
ARG A  58
MET A  62
ILE A  77
 RTL  A 135 ( 4.6A)
None
RTL  A 135 ( 3.9A)
RTL  A 135 ( 4.6A)
RTL  A 135 ( 4.4A)
None
RTL  A 135 (-2.9A)
RTL  A 135 (-3.5A)
 0.92A 5hbsA-1mx8A:
19.9		 5hbsA-1mx8A:
92.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mx8 CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO

(Rattus
norvegicus) 		PF00061
(Lipocalin) 		8 PHE A  16
TYR A  19
ALA A  33
PRO A  38
ILE A  51
ARG A  58
MET A  62
ILE A  77
 RTL  A 135 ( 4.6A)
None
RTL  A 135 ( 3.9A)
RTL  A 135 ( 4.4A)
RTL  A 135 ( 4.6A)
None
RTL  A 135 (-2.9A)
RTL  A 135 (-3.5A)
 0.95A 5hbsA-1mx8A:
19.9		 5hbsA-1mx8A:
92.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mx8 CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO

(Rattus
norvegicus) 		PF00061
(Lipocalin) 		8 PHE A  16
TYR A  19
LEU A  29
ALA A  33
ILE A  51
SER A  55
MET A  62
ILE A  77
 RTL  A 135 ( 4.6A)
None
RTL  A 135 (-3.8A)
RTL  A 135 ( 3.9A)
RTL  A 135 ( 4.6A)
RTL  A 135 ( 4.4A)
RTL  A 135 (-2.9A)
RTL  A 135 (-3.5A)
 0.92A 5hbsA-1mx8A:
19.9		 5hbsA-1mx8A:
92.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mx8 CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO

(Rattus
norvegicus) 		PF00061
(Lipocalin) 		8 PHE A  16
TYR A  19
LEU A  29
ALA A  33
PRO A  38
ILE A  51
MET A  62
ILE A  77
 RTL  A 135 ( 4.6A)
None
RTL  A 135 (-3.8A)
RTL  A 135 ( 3.9A)
RTL  A 135 ( 4.4A)
RTL  A 135 ( 4.6A)
RTL  A 135 (-2.9A)
RTL  A 135 (-3.5A)
 0.96A 5hbsA-1mx8A:
19.9		 5hbsA-1mx8A:
92.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mx8 CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO

(Rattus
norvegicus) 		PF00061
(Lipocalin) 		8 PHE A  16
TYR A  19
VAL A  25
LEU A  29
ALA A  33
ILE A  51
SER A  55
ILE A  77
 RTL  A 135 ( 4.6A)
None
None
RTL  A 135 (-3.8A)
RTL  A 135 ( 3.9A)
RTL  A 135 ( 4.6A)
RTL  A 135 ( 4.4A)
RTL  A 135 (-3.5A)
 0.86A 5hbsA-1mx8A:
19.9		 5hbsA-1mx8A:
92.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mx8 CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO

(Rattus
norvegicus) 		PF00061
(Lipocalin) 		8 PHE A  16
TYR A  19
VAL A  25
LEU A  29
ALA A  33
PRO A  38
ILE A  51
ILE A  77
 RTL  A 135 ( 4.6A)
None
None
RTL  A 135 (-3.8A)
RTL  A 135 ( 3.9A)
RTL  A 135 ( 4.4A)
RTL  A 135 ( 4.6A)
RTL  A 135 (-3.5A)
 0.88A 5hbsA-1mx8A:
19.9		 5hbsA-1mx8A:
92.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mx8 CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO

(Rattus
norvegicus) 		PF00061
(Lipocalin) 		6 VAL A  25
LEU A  29
ALA A  33
PRO A  38
ILE A  61
ILE A  77
 None
RTL  A 135 (-3.8A)
RTL  A 135 ( 3.9A)
RTL  A 135 ( 4.4A)
None
RTL  A 135 (-3.5A)
 1.33A 5hbsA-1mx8A:
19.9		 5hbsA-1mx8A:
92.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pmp P2 MYELIN PROTEIN

(Bos taurus) 		PF00061
(Lipocalin) 		5 PHE A  16
TYR A  19
VAL A  25
ILE A  51
SER A  55
 OLA  A 200 ( 4.8A)
None
None
None
OLA  A 200 ( 4.3A)
 0.71A 5hbsA-1pmpA:
19.9		 5hbsA-1pmpA:
40.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pmp P2 MYELIN PROTEIN

(Bos taurus) 		PF00061
(Lipocalin) 		5 PHE A  16
VAL A  25
PRO A  38
ILE A  51
SER A  55
 OLA  A 200 ( 4.8A)
None
None
None
OLA  A 200 ( 4.3A)
 0.77A 5hbsA-1pmpA:
19.9		 5hbsA-1pmpA:
40.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q2l PROTEASE III

(Escherichia
coli) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF16187
(Peptidase_M16_M) 		5 VAL A 333
ILE A 311
ARG A 318
ILE A 336
LEU A 376
 None
 0.93A 5hbsA-1q2lA:
undetectable		 5hbsA-1q2lA:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r20 ULTRASPIRACLE
PROTEIN
ECDYSONE RECEPTOR

(Heliothis
virescens;
Heliothis
virescens) 		PF00104
(Hormone_recep)
PF00104
(Hormone_recep) 		5 PHE D 487
LEU A 419
ALA A 415
ILE D 298
ILE D 443
 None
 1.10A 5hbsA-1r20D:
undetectable		 5hbsA-1r20D:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rw9 CHONDROITIN AC LYASE

(Paenarthrobacter
aurescens) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		5 VAL A 359
LEU A 362
ILE A 285
ILE A 313
LEU A 431
 None
 1.18A 5hbsA-1rw9A:
undetectable		 5hbsA-1rw9A:
10.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tow FATTY ACID-BINDING
PROTEIN, ADIPOCYTE

(Homo sapiens) 		PF00061
(Lipocalin) 		6 PHE A  16
TYR A  19
VAL A  25
ALA A  33
ILE A  51
SER A  55
 CRZ  A 501 (-4.5A)
None
None
CRZ  A 501 ( 4.1A)
None
CRZ  A 501 ( 4.8A)
 0.89A 5hbsA-1towA:
20.2		 5hbsA-1towA:
35.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tow FATTY ACID-BINDING
PROTEIN, ADIPOCYTE

(Homo sapiens) 		PF00061
(Lipocalin) 		6 TYR A  19
VAL A  25
ALA A  33
PRO A  38
ILE A  51
SER A  55
 None
None
CRZ  A 501 ( 4.1A)
CRZ  A 501 (-4.5A)
None
CRZ  A 501 ( 4.8A)
 0.96A 5hbsA-1towA:
20.2		 5hbsA-1towA:
35.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2x ADP-SPECIFIC
PHOSPHOFRUCTOKINASE

(Pyrococcus
horikoshii) 		PF04587
(ADP_PFK_GK) 		5 VAL A 451
LEU A 449
ILE A 169
ILE A 122
LEU A 146
 None
 1.18A 5hbsA-1u2xA:
undetectable		 5hbsA-1u2xA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x2g LIPOATE-PROTEIN
LIGASE A

(Escherichia
coli) 		PF03099
(BPL_LplA_LipB)
PF10437
(Lip_prot_lig_C) 		5 VAL A 184
LEU A 153
ALA A 156
ILE A  45
LEU A 165
 None
 1.20A 5hbsA-1x2gA:
undetectable		 5hbsA-1x2gA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfi UNKNOWN PROTEIN

(Arabidopsis
thaliana) 		PF01937
(DUF89) 		5 TYR A  21
VAL A 301
LEU A 305
ILE A 324
ILE A 296
 None
 1.08A 5hbsA-1xfiA:
undetectable		 5hbsA-1xfiA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2erc RRNA METHYL
TRANSFERASE

(Bacillus
subtilis) 		PF00398
(RrnaAD) 		5 PHE A 163
TYR A 162
PRO A 103
ILE A 154
ILE A  22
 None
 1.20A 5hbsA-2ercA:
undetectable		 5hbsA-2ercA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fuv PHOSPHOGLUCOMUTASE

(Salmonella
enterica) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 VAL A 359
LEU A 362
ILE A 413
MET A 414
ILE A 329
 None
 1.10A 5hbsA-2fuvA:
undetectable		 5hbsA-2fuvA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fuv PHOSPHOGLUCOMUTASE

(Salmonella
enterica) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 VAL A 359
LEU A 362
MET A 414
ILE A 329
LEU A 380
 None
 1.18A 5hbsA-2fuvA:
undetectable		 5hbsA-2fuvA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3e DIAMINOPIMELATE
DECARBOXYLASE

(Aquifex
aeolicus) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		5 LEU A  79
ALA A  81
PRO A 280
ILE A 247
ILE A  44
 None
 1.10A 5hbsA-2p3eA:
undetectable		 5hbsA-2p3eA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbi GUANINE
NUCLEOTIDE-BINDING
PROTEIN SUBUNIT BETA
5

(Mus musculus) 		PF00400
(WD40) 		5 PHE B 299
VAL B 318
LEU B  48
SER B 294
ARG B 296
 None
None
GOL  A 905 ( 3.4A)
None
None
 1.12A 5hbsA-2pbiB:
undetectable		 5hbsA-2pbiB:
17.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q9s FATTY ACID-BINDING
PROTEIN

(Mus musculus) 		PF00061
(Lipocalin) 		6 PHE A  16
TYR A  19
VAL A  25
ALA A  33
ILE A  51
SER A  55
 None
None
None
EIC  A 601 (-3.5A)
None
None
 0.83A 5hbsA-2q9sA:
20.0		 5hbsA-2q9sA:
31.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q9s FATTY ACID-BINDING
PROTEIN

(Mus musculus) 		PF00061
(Lipocalin) 		6 PHE A  16
VAL A  25
ALA A  33
PRO A  38
ILE A  51
SER A  55
 None
None
EIC  A 601 (-3.5A)
EIC  A 601 (-4.6A)
None
None
 0.88A 5hbsA-2q9sA:
20.0		 5hbsA-2q9sA:
31.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ql3 PROBABLE
TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY PROTEIN

(Rhodococcus
jostii) 		PF03466
(LysR_substrate) 		5 PHE A 234
LEU A 111
ALA A 110
ILE A 270
SER A 210
 None
 1.20A 5hbsA-2ql3A:
undetectable		 5hbsA-2ql3A:
21.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rcq RETINOL-BINDING
PROTEIN II, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		6 PHE A  16
TYR A  19
ALA A  33
SER A  55
ARG A  58
LEU A 117
 None
None
None
None
SO4  A 152 (-3.1A)
None
 0.80A 5hbsA-2rcqA:
24.0		 5hbsA-2rcqA:
51.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtz UDP-N-ACETYLMURAMOYL
-L-ALANYL-D-GLUTAMAT
E--2,6-DIAMINOPIMELA
TE LIGASE

(Mycobacterium
tuberculosis) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 VAL A 164
LEU A 168
ALA A 175
ILE A 149
LEU A 202
 None
 1.09A 5hbsA-2wtzA:
undetectable		 5hbsA-2wtzA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z0s PROBABLE EXOSOME
COMPLEX RNA-BINDING
PROTEIN 1

(Aeropyrum
pernix) 		PF15985
(KH_6) 		5 TYR A 120
VAL A  84
LEU A 136
ALA A 123
ILE A 154
 None
 1.19A 5hbsA-2z0sA:
undetectable		 5hbsA-2z0sA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3y O-METHYLTRANSFERASE

(Mesembryanthemum
crystallinum) 		PF01596
(Methyltransf_3) 		5 VAL A  65
LEU A  66
MET A 168
ILE A 176
LEU A 213
 None
 1.19A 5hbsA-3c3yA:
undetectable		 5hbsA-3c3yA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgx PUTATIVE
NUCLEOTIDE-DIPHOSPHO
-SUGAR TRANSFERASE

(Desulfovibrio
alaskensis) 		PF09837
(DUF2064) 		5 TYR A  35
VAL A 191
LEU A 200
SER A 212
LEU A  72
 IMD  A 242 (-3.8A)
None
None
None
None
 1.18A 5hbsA-3cgxA:
undetectable		 5hbsA-3cgxA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ed4 ARYLSULFATASE

(Escherichia
coli) 		PF00884
(Sulfatase) 		5 VAL A  79
ILE A 128
SER A 403
ILE A 360
LEU A  98
 None
 1.20A 5hbsA-3ed4A:
undetectable		 5hbsA-3ed4A:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ek5 URIDYLATE KINASE

(Xanthomonas
campestris) 		PF00696
(AA_kinase) 		5 LEU A   4
ALA A  44
ILE A 130
ILE A   9
LEU A  34
 None
 0.92A 5hbsA-3ek5A:
undetectable		 5hbsA-3ek5A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hur ALANINE RACEMASE

(Oenococcus oeni) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 LEU A 365
ALA A 366
ILE A 311
ARG A 296
LEU A 285
 None
SO4  A 396 ( 4.5A)
None
None
None
 1.05A 5hbsA-3hurA:
undetectable		 5hbsA-3hurA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I)
PF01590
(GAF)
PF13185
(GAF_2) 		5 PHE A 404
LEU A 396
ALA A 400
ILE A 515
ILE A 542
 None
 1.09A 5hbsA-3ibjA:
undetectable		 5hbsA-3ibjA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kg9 CURK

(Lyngbya
majuscula) 		PF14765
(PS-DH) 		5 PHE A1004
VAL A1048
PRO A1165
ILE A1194
ILE A1064
 None
 1.18A 5hbsA-3kg9A:
2.4		 5hbsA-3kg9A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l09 PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Jannaschia sp.
CCS1) 		PF07848
(PaaX) 		5 PHE A 203
LEU A  47
ILE A 102
SER A  35
LEU A 245
 None
 1.10A 5hbsA-3l09A:
undetectable		 5hbsA-3l09A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7z PROBABLE EXOSOME
COMPLEX RNA-BINDING
PROTEIN 1

(Sulfolobus
solfataricus) 		no annotation 5 TYR C 125
VAL C  90
LEU C 141
ALA C 128
ILE C 159
 None
 1.15A 5hbsA-3l7zC:
undetectable		 5hbsA-3l7zC:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lfv CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF01590
(GAF) 		5 PHE A 341
LEU A 333
ALA A 337
ILE A 465
ILE A 497
 None
 1.20A 5hbsA-3lfvA:
undetectable		 5hbsA-3lfvA:
15.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3nr3 PMP2 PROTEIN

(Homo sapiens) 		PF00061
(Lipocalin) 		6 PHE A  17
TYR A  20
VAL A  26
PRO A  39
ILE A  52
SER A  56
 None
None
None
SO4  A 903 ( 4.8A)
None
PLM  A 901 (-3.7A)
 0.62A 5hbsA-3nr3A:
19.8		 5hbsA-3nr3A:
34.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o1k DIHYDRONEOPTERIN
ALDOLASE FOLB,
PUTATIVE

(Vibrio cholerae) 		PF02152
(FolB) 		5 VAL A 101
LEU A  63
ILE A  76
ILE A  95
LEU A 108
 None
 1.20A 5hbsA-3o1kA:
undetectable		 5hbsA-3o1kA:
20.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pp6 SODIUM-CALCIUM
EXCHANGER

(Doryteuthis
pealeii) 		PF00061
(Lipocalin) 		6 PHE A  17
TYR A  20
VAL A  26
ALA A  34
PRO A  39
ILE A  52
 None
None
None
PAM  A 133 ( 3.7A)
PAM  A 133 (-4.4A)
None
 0.73A 5hbsA-3pp6A:
21.0		 5hbsA-3pp6A:
36.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppb PUTATIVE TETR FAMILY
TRANSCRIPTION
REGULATOR

(Shewanella
loihica) 		PF00440
(TetR_N) 		5 PHE A 187
LEU A  81
ALA A  85
MET A 124
ILE A 135
 PG4  A 216 (-4.7A)
None
PG4  A 216 ( 4.1A)
None
None
 1.12A 5hbsA-3ppbA:
undetectable		 5hbsA-3ppbA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sx2 PUTATIVE
3-KETOACYL-(ACYL-CAR
RIER-PROTEIN)
REDUCTASE

(Mycobacterium
avium) 		PF13561
(adh_short_C2) 		5 VAL A 152
ALA A 250
ILE A 211
MET A 210
ILE A 154
 None
None
NAD  A 300 (-3.8A)
NAD  A 300 (-3.7A)
NAD  A 300 (-4.7A)
 1.20A 5hbsA-3sx2A:
undetectable		 5hbsA-3sx2A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vcy UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Aliivibrio
fischeri) 		PF00275
(EPSP_synthase) 		5 LEU A 371
ALA A 375
ILE A 281
ILE A 234
LEU A 267
 None
 0.97A 5hbsA-3vcyA:
undetectable		 5hbsA-3vcyA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vla EDGP

(Daucus carota) 		PF14541
(TAXi_C)
PF14543
(TAXi_N) 		5 VAL A 241
LEU A 258
SER A 282
ILE A 244
LEU A 359
 None
 0.97A 5hbsA-3vlaA:
undetectable		 5hbsA-3vlaA:
15.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wbg FATTY ACID-BINDING
PROTEIN, HEART

(Homo sapiens) 		PF00061
(Lipocalin) 		7 PHE A  16
TYR A  19
VAL A  25
ALA A  33
PRO A  38
SER A  55
LEU A 115
 2AN  A 201 ( 4.9A)
2AN  A 201 (-4.8A)
None
2AN  A 201 (-3.8A)
2AN  A 201 ( 4.3A)
2AN  A 201 (-3.2A)
None
 0.81A 5hbsA-3wbgA:
20.3		 5hbsA-3wbgA:
35.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zh4 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Streptococcus
pneumoniae) 		PF00275
(EPSP_synthase) 		5 LEU A 371
ALA A 375
ILE A 282
ILE A 235
LEU A 268
 FLC  A1419 (-4.0A)
None
None
None
None
 1.15A 5hbsA-3zh4A:
undetectable		 5hbsA-3zh4A:
12.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4a60 FATTY ACID-BINDING
PROTEIN 9 TESTIS
LIPID-BINDING
PROTEIN, TLBP,
TESTIS-TYPE FATTY
ACID-BINDING
PROTEIN, T-FABP

(Homo sapiens) 		PF00061
(Lipocalin) 		7 PHE A  17
TYR A  20
VAL A  26
ALA A  34
PRO A  39
ILE A  52
SER A  56
 None
None
None
NA  A1132 ( 4.0A)
None
None
NA  A1132 (-2.9A)
 0.63A 5hbsA-4a60A:
19.0		 5hbsA-4a60A:
30.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4azp FATTY ACID-BINDING
PROTEIN, EPIDERMAL

(Mus musculus) 		PF00061
(Lipocalin) 		5 PHE A  19
TYR A  22
VAL A  28
ALA A  36
SER A  58
 None
None
None
A9M  A1136 (-3.4A)
A9M  A1136 ( 4.1A)
 0.77A 5hbsA-4azpA:
20.6		 5hbsA-4azpA:
33.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4azp FATTY ACID-BINDING
PROTEIN, EPIDERMAL

(Mus musculus) 		PF00061
(Lipocalin) 		5 TYR A  22
VAL A  28
LEU A  32
ALA A  36
SER A  58
 None
None
A9M  A1136 ( 4.1A)
A9M  A1136 (-3.4A)
A9M  A1136 ( 4.1A)
 0.87A 5hbsA-4azpA:
20.6		 5hbsA-4azpA:
33.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bf7 ARABINOGALACTAN
ENDO-1,4-BETA-GALACT
OSIDASE A

(Aspergillus
nidulans) 		PF07745
(Glyco_hydro_53) 		6 TYR A 294
VAL A  41
LEU A  36
ILE A  48
SER A  11
ILE A  44
 None
 1.38A 5hbsA-4bf7A:
undetectable		 5hbsA-4bf7A:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c2l ENDO-XYLOGALACTURONA
N HYDROLASE A

(Aspergillus
tubingensis) 		PF00295
(Glyco_hydro_28) 		5 VAL A 271
ALA A 283
SER A 279
MET A 193
ILE A 245
 None
 1.20A 5hbsA-4c2lA:
undetectable		 5hbsA-4c2lA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cp6 CHOLINE BINDING
PROTEIN PCPA

(Streptococcus
pneumoniae) 		PF13306
(LRR_5) 		5 VAL A 101
PRO A 172
ILE A 203
SER A 174
LEU A 192
 None
 1.11A 5hbsA-4cp6A:
undetectable		 5hbsA-4cp6A:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e51 HISTIDINE--TRNA
LIGASE

(Burkholderia
thailandensis) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		5 VAL A 255
LEU A 250
ALA A 149
MET A 313
LEU A  39
 None
 1.14A 5hbsA-4e51A:
undetectable		 5hbsA-4e51A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f9o HEXOKINASE-1

(Homo sapiens) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		5 VAL A 678
LEU A 864
ILE A 721
ILE A 745
LEU A 484
 None
 1.03A 5hbsA-4f9oA:
undetectable		 5hbsA-4f9oA:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h0c PHOSPHOLIPASE/CARBOX
YLESTERASE

(Dyadobacter
fermentans) 		PF02230
(Abhydrolase_2) 		5 VAL A  68
ALA A 138
ILE A 153
ARG A 117
ILE A 133
 None
 1.07A 5hbsA-4h0cA:
undetectable		 5hbsA-4h0cA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h5u PROBABLE HYDROLASE
NIT2

(Saccharomyces
cerevisiae) 		PF00795
(CN_hydrolase) 		5 VAL A  26
LEU A  13
ALA A  11
ILE A 157
ILE A  90
 None
 1.14A 5hbsA-4h5uA:
undetectable		 5hbsA-4h5uA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hb4 EXPORTIN-1

(Saccharomyces
cerevisiae) 		PF03810
(IBN_N)
PF08389
(Xpo1)
PF08767
(CRM1_C) 		5 LEU C 791
ALA C 794
ILE C 679
ILE C 766
LEU C 690
 None
 1.16A 5hbsA-4hb4C:
undetectable		 5hbsA-4hb4C:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		5 ALA A 384
ILE A 392
SER A 387
ILE A 331
LEU A 415
 None
 1.19A 5hbsA-4hq1A:
undetectable		 5hbsA-4hq1A:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpo NUCLEOSIDE
N-RIBOHYDROLASE 3

(Zea mays) 		PF01156
(IU_nuc_hydro) 		5 VAL A 177
LEU A 126
ALA A 122
SER A 243
ILE A 184
 None
 1.15A 5hbsA-4kpoA:
undetectable		 5hbsA-4kpoA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kq6 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE

([Candida]
glabrata) 		PF00885
(DMRL_synthase) 		5 VAL A  90
LEU A 126
ALA A 138
ILE A  53
ILE A  88
 None
 1.12A 5hbsA-4kq6A:
undetectable		 5hbsA-4kq6A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4my2 MALTOSE-BINDING
PERIPLASMIC PROTEIN,
NORRIN FUSION
PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF00007
(Cys_knot)
PF13416
(SBP_bac_8) 		5 VAL A 185
LEU A 363
ALA A 348
ILE A 228
ILE A 163
 None
 1.08A 5hbsA-4my2A:
undetectable		 5hbsA-4my2A:
16.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nns FATTY ACID-BINDING
PROTEIN, ADIPOCYTE

(Homo sapiens) 		PF00061
(Lipocalin) 		6 PHE A  16
TYR A  19
VAL A  25
ALA A  33
ILE A  51
SER A  55
 None
None
None
75D  A 201 ( 4.1A)
None
75D  A 201 ( 4.7A)
 0.89A 5hbsA-4nnsA:
19.8		 5hbsA-4nnsA:
31.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nns FATTY ACID-BINDING
PROTEIN, ADIPOCYTE

(Homo sapiens) 		PF00061
(Lipocalin) 		6 TYR A  19
VAL A  25
ALA A  33
PRO A  38
ILE A  51
SER A  55
 None
None
75D  A 201 ( 4.1A)
75D  A 201 (-4.4A)
None
75D  A 201 ( 4.7A)
 0.93A 5hbsA-4nnsA:
19.8		 5hbsA-4nnsA:
31.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4okr MICRONEMAL PROTEIN
MIC2

(Toxoplasma
gondii) 		PF00090
(TSP_1)
PF00092
(VWA) 		5 PHE A  98
LEU A 245
ALA A 255
ILE A 108
ILE A 184
 None
 0.88A 5hbsA-4okrA:
undetectable		 5hbsA-4okrA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oku MICRONEMAL PROTEIN
MIC2

(Toxoplasma
gondii) 		PF00090
(TSP_1)
PF00092
(VWA) 		5 PHE A  98
LEU A 245
ALA A 255
ILE A 108
ILE A 184
 None
 0.90A 5hbsA-4okuA:
undetectable		 5hbsA-4okuA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozt ECDYSONE RECEPTOR
RETINOID X RECEPTOR

(Pediculus
humanus;
Pediculus
humanus) 		PF00104
(Hormone_recep)
PF00104
(Hormone_recep) 		5 PHE E 477
LEU U 353
ALA U 349
ILE E 292
ILE E 435
 None
 1.05A 5hbsA-4oztE:
undetectable		 5hbsA-4oztE:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q0c VIRULENCE SENSOR
PROTEIN BVGS

(Bordetella
pertussis) 		PF00497
(SBP_bac_3) 		5 PHE A 375
VAL A 356
LEU A 314
ILE A 397
SER A 465
 None
 1.15A 5hbsA-4q0cA:
undetectable		 5hbsA-4q0cA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qp0 ENDO-BETA-MANNANASE

(Rhizomucor
miehei) 		PF00150
(Cellulase) 		5 PHE A  12
VAL A  51
ALA A 320
ILE A 172
ILE A 104
 None
 1.15A 5hbsA-4qp0A:
undetectable		 5hbsA-4qp0A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7u UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Vibrio cholerae) 		PF00275
(EPSP_synthase) 		5 LEU A 371
ALA A 375
ILE A 281
ILE A 234
LEU A 267
 None
 1.03A 5hbsA-4r7uA:
undetectable		 5hbsA-4r7uA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rrp ANTIGEN ASF1P

(Saccharomyces
cerevisiae) 		PF04729
(ASF1_hist_chap) 		5 VAL M 130
ALA M  81
PRO M  79
ILE M 139
ILE M 135
 None
 1.13A 5hbsA-4rrpM:
undetectable		 5hbsA-4rrpM:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wrn MALTOSE-BINDING
PERIPLASMIC
PROTEIN,UROMODULIN

(Escherichia
coli;
Homo sapiens) 		PF00100
(Zona_pellucida)
PF13416
(SBP_bac_8) 		5 VAL A 207
LEU A 385
ALA A 370
ILE A 250
ILE A 185
 None
 1.12A 5hbsA-4wrnA:
undetectable		 5hbsA-4wrnA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 5 VAL B 190
ALA B 156
SER B 173
ARG B 153
LEU B 214
 None
 1.20A 5hbsA-4xeyB:
undetectable		 5hbsA-4xeyB:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7r COENZYME PQQ
SYNTHESIS PROTEIN B

(Methylobacterium
extorquens) 		PF12706
(Lactamase_B_2) 		5 TYR A 192
VAL A   3
LEU A 297
ALA A 212
ILE A   5
 None
 1.02A 5hbsA-4z7rA:
undetectable		 5hbsA-4z7rA:
19.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5b29 FATTY ACID-BINDING
PROTEIN, HEART

(Homo sapiens) 		PF00061
(Lipocalin) 		6 TYR A  19
VAL A  25
ALA A  33
PRO A  38
SER A  55
LEU A 115
 None
None
PLM  A 200 ( 3.7A)
PLM  A 200 ( 4.9A)
PLM  A 200 ( 4.1A)
None
 0.83A 5hbsA-5b29A:
20.5		 5hbsA-5b29A:
34.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5bvq FATTY ACID-BINDING
PROTEIN

(Pygoscelis
papua) 		PF00061
(Lipocalin) 		5 PHE A  17
TYR A  20
VAL A  26
ALA A  34
ILE A  52
 None
 0.75A 5hbsA-5bvqA:
19.6		 5hbsA-5bvqA:
37.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5crj TRANSCRIPTION
TERMINATION FACTOR
1, MITOCHONDRIAL

(Homo sapiens) 		PF02536
(mTERF) 		5 VAL O 150
LEU O 197
ILE O 121
SER O 163
ILE O 156
 None
 1.13A 5hbsA-5crjO:
undetectable		 5hbsA-5crjO:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csc CITRATE SYNTHASE

(Gallus gallus) 		PF00285
(Citrate_synt) 		5 LEU B 403
ALA B 402
ILE B 200
MET B 216
LEU B 120
 None
 1.01A 5hbsA-5cscB:
undetectable		 5hbsA-5cscB:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL

(Homo sapiens) 		PF00117
(GATase)
PF00988
(CPSase_sm_chain)
PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		5 VAL A 422
LEU A 743
ALA A 742
ILE A 487
MET A 462
 None
 1.11A 5hbsA-5dotA:
undetectable		 5hbsA-5dotA:
7.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gkb FATTY ACID BINDIN
PROTEIN, ISOFORM B

(Drosophila
melanogaster) 		PF00061
(Lipocalin) 		5 PHE A  16
TYR A  19
VAL A  25
PRO A  38
SER A  55
 None
 0.70A 5hbsA-5gkbA:
19.6		 5hbsA-5gkbA:
35.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hz5 FATTY ACID-BINDING
PROTEIN, EPIDERMAL

(Homo sapiens) 		PF00061
(Lipocalin) 		5 PHE A  19
TYR A  22
VAL A  28
LEU A  32
ILE A  54
 65X  A 203 ( 4.7A)
65X  A 203 ( 4.7A)
None
65X  A 203 (-3.6A)
None
 0.81A 5hbsA-5hz5A:
20.7		 5hbsA-5hz5A:
31.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8s CAMP-DEPENDENT
PROTEIN KINASE
REGULATORY SUBUNIT

(Plasmodium
falciparum) 		PF00027
(cNMP_binding) 		5 PHE A 349
TYR A 374
VAL A 310
LEU A 307
LEU A 381
 None
 1.20A 5hbsA-5k8sA:
undetectable		 5hbsA-5k8sA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5knm CDNA FLJ39643 FIS,
CLONE SMINT2004023,
HIGHLY SIMILAR TO
HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, ALPHACHAIN
F
BETA-2-MICROGLOBULIN

(Homo sapiens;
Homo sapiens) 		PF00129
(MHC_I)
PF07654
(C1-set)
PF07654
(C1-set) 		5 TYR B  66
VAL B  82
ILE A  23
SER B  61
ILE B  35
 None
 1.07A 5hbsA-5knmB:
undetectable		 5hbsA-5knmB:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrr LYTIC ENDOPEPTIDASE
PREPROENZYME

(Lysobacter sp.
XL1) 		no annotation 5 LEU A 196
ALA A 155
SER A 147
ILE A 188
LEU A 132
 None
 1.19A 5hbsA-5mrrA:
undetectable		 5hbsA-5mrrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wbf METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER (TLPC)

(Helicobacter
pylori) 		no annotation 5 PHE A  93
LEU A 167
ALA A  67
ILE A  56
ILE A 165
 None
 1.20A 5hbsA-5wbfA:
undetectable		 5hbsA-5wbfA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbq PEROXIREDOXIN

(Pyrococcus
horikoshii) 		no annotation 5 VAL A 153
LEU A 152
ALA A 134
ILE A  98
LEU A  22
 None
 1.13A 5hbsA-5xbqA:
undetectable		 5hbsA-5xbqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yim SDEA

(Legionella
pneumophila) 		no annotation 5 PHE A 965
TYR A 962
PRO A 997
SER A 998
LEU A 946
 None
 1.19A 5hbsA-5yimA:
undetectable		 5hbsA-5yimA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evg MULTI-COPPER OXIDASE
CUEO

(Ochrobactrum) 		no annotation 5 PHE A 301
VAL A 272
LEU A 243
ILE A 204
ILE A 224
 None
 1.19A 5hbsA-6evgA:
undetectable		 5hbsA-6evgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
12as ASPARAGINE
SYNTHETASE

(Escherichia
coli) 		PF03590
(AsnA) 		4 LEU A 261
THR A  44
GLN A  83
MET A 287
 None
 1.13A 5hbsA-12asA:
0.2		 5hbsA-12asA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a6j NITROGEN REGULATORY
IIA PROTEIN

(Escherichia
coli) 		PF00359
(PTS_EIIA_2) 		4 LEU A 106
THR A  19
TYR A 150
GLN A  42
 None
 1.20A 5hbsA-1a6jA:
undetectable		 5hbsA-1a6jA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fbw ENDO-1,4-BETA-GLUCAN
ASE F

([Clostridium]
cellulolyticum) 		PF02011
(Glyco_hydro_48) 		4 LEU A 149
THR A 226
TYR A 299
GLN A 194
 None
GLC  A3097 ( 3.0A)
GLC  A3097 ( 4.1A)
None
 1.19A 5hbsA-1fbwA:
0.0		 5hbsA-1fbwA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gg4 UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMYL-2,
6-DIAMINOPIMELATE-D-
ALANYL-D-ALANYL
LIGASE

(Escherichia
coli) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 LEU A 105
THR A 128
TYR A 130
GLN A 124
 None
 1.14A 5hbsA-1gg4A:
0.0		 5hbsA-1gg4A:
13.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ggl PROTEIN (CELLULAR
RETINOL-BINDING
PROTEIN III)

(Homo sapiens) 		PF00061
(Lipocalin) 		6 LEU A  20
LEU A  36
LYS A  40
THR A  53
TYR A  60
TRP A 106
 None
 0.51A 5hbsA-1gglA:
23.2		 5hbsA-1gglA:
53.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kl7 THREONINE SYNTHASE

(Saccharomyces
cerevisiae) 		PF00291
(PALP)
PF14821
(Thr_synth_N) 		4 LEU A  99
LEU A 447
THR A 430
TYR A 444
 None
 1.11A 5hbsA-1kl7A:
0.0		 5hbsA-1kl7A:
13.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kqx CELLULAR
RETINOL-BINDING
PROTEIN

(Danio rerio) 		PF00061
(Lipocalin) 		5 LEU A  36
LYS A  40
THR A  53
TRP A 106
GLN A 108
 None
 0.85A 5hbsA-1kqxA:
24.2		 5hbsA-1kqxA:
58.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l6w FRUCTOSE-6-PHOSPHATE
ALDOLASE 1

(Escherichia
coli) 		PF00923
(TAL_FSA) 		4 LEU A 149
LEU A 119
TYR A 112
GLN A  59
 None
 1.11A 5hbsA-1l6wA:
0.0		 5hbsA-1l6wA:
19.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lpj RETINOL-BINDING
PROTEIN IV, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		5 LEU A  36
LYS A  40
THR A  53
TRP A 106
MET A 119
 None
 0.58A 5hbsA-1lpjA:
23.8		 5hbsA-1lpjA:
55.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m7j D-AMINOACYLASE

(Alcaligenes
faecalis) 		PF07969
(Amidohydro_3) 		4 LEU A 115
THR A  68
GLN A  86
MET A  80
 None
 1.17A 5hbsA-1m7jA:
undetectable		 5hbsA-1m7jA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nun FIBROBLAST GROWTH
FACTOR-10

(Homo sapiens) 		PF00167
(FGF) 		4 LEU A 132
LEU A 180
THR A 192
TYR A 177
 None
 1.18A 5hbsA-1nunA:
undetectable		 5hbsA-1nunA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1poy SPERMIDINE/PUTRESCIN
E-BINDING PROTEIN

(Escherichia
coli) 		PF13416
(SBP_bac_8) 		4 LEU 1 110
LEU 1 104
TYR 1 129
GLN 1 286
 None
 1.14A 5hbsA-1poy1:
undetectable		 5hbsA-1poy1:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szq 2-METHYLCITRATE
DEHYDRATASE

(Escherichia
coli) 		PF03972
(MmgE_PrpD) 		4 LEU A 145
LEU A 121
THR A  44
MET A 278
 None
 1.12A 5hbsA-1szqA:
undetectable		 5hbsA-1szqA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tpy METHOXY MYCOLIC ACID
SYNTHASE 2

(Mycobacterium
tuberculosis) 		PF02353
(CMAS) 		4 LEU A 222
LEU A 166
THR A 170
GLN A 229
 None
 1.13A 5hbsA-1tpyA:
undetectable		 5hbsA-1tpyA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u7h ORNITHINE
CYCLODEAMINASE

(Pseudomonas
putida) 		PF02423
(OCD_Mu_crystall) 		4 LEU A 105
LEU A  91
TYR A 306
MET A  10
 None
 1.10A 5hbsA-1u7hA:
0.8		 5hbsA-1u7hA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wac P2 PROTEIN

(Pseudomonas
virus phi6) 		PF00680
(RdRP_1) 		4 LEU A 471
LEU A 415
THR A 409
TYR A 410
 None
 1.03A 5hbsA-1wacA:
undetectable		 5hbsA-1wacA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygu LEUKOCYTE COMMON
ANTIGEN

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 LEU A 897
LEU A1161
TYR A1197
GLN A1174
 None
 1.16A 5hbsA-1yguA:
undetectable		 5hbsA-1yguA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yr7 ATP(GTP)BINDING
PROTEIN

(Pyrococcus
abyssi) 		PF03029
(ATP_bind_1) 		4 LEU A 222
LEU A 236
THR A 160
TYR A 129
 None
 1.10A 5hbsA-1yr7A:
undetectable		 5hbsA-1yr7A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z9a NAD(P)H-DEPENDENT
D-XYLOSE REDUCTASE

([Candida]
tenuis) 		PF00248
(Aldo_ket_red) 		4 LEU A 260
LEU A 303
THR A 236
GLN A 230
 None
 1.17A 5hbsA-1z9aA:
undetectable		 5hbsA-1z9aA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ecf DIPEPTIDYL PEPTIDASE
IV

(Stenotrophomonas
maltophilia) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 LEU A 619
LEU A 558
THR A 531
TYR A 524
 None
 1.14A 5hbsA-2ecfA:
undetectable		 5hbsA-2ecfA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gdt LEADER PROTEIN
P65 HOMOLOG
NSP1 (EC 3.4.22.-)

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF11501
(Nsp1) 		4 LEU A  53
LEU A  96
THR A  92
GLN A  85
 None
 1.20A 5hbsA-2gdtA:
undetectable		 5hbsA-2gdtA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA

(Homo sapiens) 		PF00899
(ThiF)
PF08825
(E2_bind)
PF13416
(SBP_bac_8) 		4 LEU B1291
LEU B1263
THR B1094
GLN B1326
 None
 1.18A 5hbsA-2nvuB:
undetectable		 5hbsA-2nvuB:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ol3 ALLOGENEIC H-2KBM8
MHC CLASS I MOLECULE

(Mus musculus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 LEU H 156
LYS H  66
TYR H   7
TRP H 167
 None
 1.21A 5hbsA-2ol3H:
undetectable		 5hbsA-2ol3H:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pjr PROTEIN (HELICASE
PCRA)
PROTEIN (HELICASE
PCRA)

(Geobacillus
stearothermophilus;
Geobacillus
stearothermophilus) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C)
PF13361
(UvrD_C) 		4 THR B 618
TYR A 324
GLN A 363
MET A 367
 None
 1.20A 5hbsA-2pjrB:
undetectable		 5hbsA-2pjrB:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ppg PUTATIVE ISOMERASE

(Sinorhizobium
meliloti) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 374
LEU A 145
GLN A 298
MET A 291
 None
 1.18A 5hbsA-2ppgA:
undetectable		 5hbsA-2ppgA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyj DNA POLYMERASE

(Bacillus virus
phi29) 		PF03175
(DNA_pol_B_2) 		4 LEU A 342
LEU A 328
THR A 301
GLN A 446
 None
 1.13A 5hbsA-2pyjA:
undetectable		 5hbsA-2pyjA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qsx PUTATIVE
TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY

(Vibrio
parahaemolyticus) 		PF03466
(LysR_substrate) 		4 LEU A 211
LEU A  31
THR A  23
GLN A 112
 None
None
SO4  A 216 ( 3.2A)
SO4  A 216 ( 4.4A)
 1.10A 5hbsA-2qsxA:
undetectable		 5hbsA-2qsxA:
19.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rcq RETINOL-BINDING
PROTEIN II, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		4 LYS A  40
THR A  53
TRP A 106
GLN A 108
 None
 0.49A 5hbsA-2rcqA:
24.0		 5hbsA-2rcqA:
51.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7b BENZOATE-COENZYME A
LIGASE

(Paraburkholderia
xenovorans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 LEU A 365
LEU A 417
THR A 354
TYR A 424
 None
 1.17A 5hbsA-2v7bA:
undetectable		 5hbsA-2v7bA:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vmf BETA-MANNOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2) 		4 LEU A 114
LEU A 152
TYR A 155
TRP A  89
 None
 1.17A 5hbsA-2vmfA:
undetectable		 5hbsA-2vmfA:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3a PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT BETA ISOFORM

(Mus musculus) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
PF02192
(PI3K_p85B) 		4 LEU A 633
LEU A 640
TYR A 692
TRP A 670
 None
 1.17A 5hbsA-2y3aA:
undetectable		 5hbsA-2y3aA:
8.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfs LEVANSUCRASE

(Lactobacillus
johnsonii) 		PF02435
(Glyco_hydro_68) 		4 LEU A 476
LEU A 469
GLN A 219
MET A 518
 None
 1.16A 5hbsA-2yfsA:
undetectable		 5hbsA-2yfsA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1b DELTA-AMINOLEVULINIC
ACID DEHYDRATASE

(Mus musculus) 		PF00490
(ALAD) 		4 LEU A 273
LEU A 258
TYR A 276
GLN A 225
 None
 0.97A 5hbsA-2z1bA:
undetectable		 5hbsA-2z1bA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b5o CADD-LIKE PROTEIN OF
UNKNOWN FUNCTION

(Nostoc
punctiforme) 		PF12981
(DUF3865) 		4 LEU A 171
LEU A 152
TYR A  95
GLN A  46
 None
 1.07A 5hbsA-3b5oA:
undetectable		 5hbsA-3b5oA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bmw CYCLOMALTODEXTRIN
GLUCANOTRANSFERASE

(Thermoanaerobacterium
thermosulfurigenes) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		4 LEU A 397
LEU A 460
THR A 457
TYR A 456
 None
 1.12A 5hbsA-3bmwA:
undetectable		 5hbsA-3bmwA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmi PEROXIREDOXIN HYR1

(Saccharomyces
cerevisiae) 		PF00255
(GSHPx) 		4 LEU A 159
LEU A 131
TYR A  49
GLN A  21
 None
 1.16A 5hbsA-3cmiA:
undetectable		 5hbsA-3cmiA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cnj CHOLESTEROL OXIDASE

(Streptomyces
sp. SA-COO) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 LEU A 292
LEU A 449
TYR A 446
MET A 104
 None
None
FAD  A 510 (-3.6A)
None
 1.18A 5hbsA-3cnjA:
undetectable		 5hbsA-3cnjA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctp PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR

(Alkaliphilus
metalliredigens) 		PF13377
(Peripla_BP_3) 		4 LEU A 112
LEU A  95
THR A  92
TYR A  91
 None
 1.13A 5hbsA-3ctpA:
undetectable		 5hbsA-3ctpA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e23 UNCHARACTERIZED
PROTEIN RPA2492

(Rhodopseudomonas
palustris) 		PF08241
(Methyltransf_11) 		4 LEU A  41
LEU A 131
TYR A 138
MET A  61
 None
 1.01A 5hbsA-3e23A:
undetectable		 5hbsA-3e23A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eaf ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN

(Aeropyrum
pernix) 		PF13458
(Peripla_BP_6) 		4 LEU A 185
LEU A 270
TYR A 189
MET A 236
 None
 1.16A 5hbsA-3eafA:
undetectable		 5hbsA-3eafA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3if2 AMINOTRANSFERASE

(Psychrobacter
arcticus) 		PF00155
(Aminotran_1_2) 		4 LEU A 351
LEU A 439
THR A 378
TRP A 368
 None
 1.09A 5hbsA-3if2A:
undetectable		 5hbsA-3if2A:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ig4 XAA-PRO
AMINOPEPTIDASE

(Bacillus
anthracis) 		PF00557
(Peptidase_M24)
PF05195
(AMP_N) 		4 LEU A 317
LEU A 293
THR A 271
GLN A 282
 None
 1.08A 5hbsA-3ig4A:
undetectable		 5hbsA-3ig4A:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9b LIVER
CARBOXYLESTERASE 1

(Homo sapiens) 		PF00135
(COesterase) 		4 LEU A1110
LEU A1051
THR A1167
TYR A1152
 None
 1.03A 5hbsA-3k9bA:
undetectable		 5hbsA-3k9bA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvu TENA FAMILY
TRANSCRIPTIONAL
REGULATOR

(Ruegeria sp.
TM1040) 		PF03070
(TENA_THI-4) 		4 LEU A  83
LEU A 137
THR A 118
GLN A  48
 None
None
None
CL  A 239 (-4.0A)
 1.10A 5hbsA-3mvuA:
undetectable		 5hbsA-3mvuA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n28 PHOSPHOSERINE
PHOSPHATASE

(Vibrio cholerae) 		PF00702
(Hydrolase) 		4 LEU A  75
TYR A  95
GLN A  48
MET A  52
 None
 1.15A 5hbsA-3n28A:
undetectable		 5hbsA-3n28A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nfz ASPARTOACYLASE-2

(Mus musculus) 		PF04952
(AstE_AspA) 		4 LEU A 115
LEU A  52
TYR A  33
GLN A  42
 None
 1.19A 5hbsA-3nfzA:
undetectable		 5hbsA-3nfzA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ny7 SULFATE TRANSPORTER

(Escherichia
coli) 		PF01740
(STAS) 		4 LEU A 537
LEU A 483
GLN A 520
MET A 525
 None
 1.14A 5hbsA-3ny7A:
undetectable		 5hbsA-3ny7A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfe SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Legionella
pneumophila) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 LEU A 448
LEU A 456
THR A 139
GLN A  13
 None
 1.05A 5hbsA-3pfeA:
undetectable		 5hbsA-3pfeA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9n CONSENSUS ANKYRIN
REPEAT

(Escherichia
coli) 		PF12796
(Ank_2)
PF13637
(Ank_4) 		4 LEU C 120
LEU C  87
TYR C  77
TRP C 102
 None
 1.18A 5hbsA-3q9nC:
undetectable		 5hbsA-3q9nC:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qc5 PLATELET BINDING
PROTEIN GSPB

(Streptococcus
gordonii) 		no annotation 4 LEU X 373
THR X 382
GLN X 288
MET X 263
 None
 1.07A 5hbsA-3qc5X:
undetectable		 5hbsA-3qc5X:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6p BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 2

(Homo sapiens) 		PF00619
(CARD)
PF00653
(BIR)
PF13920
(zf-C3HC4_3) 		4 LEU A 313
LYS A 416
THR A 420
TYR A 352
 None
 1.16A 5hbsA-3t6pA:
undetectable		 5hbsA-3t6pA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4av2 PILP PROTEIN

(Neisseria
meningitidis) 		PF04351
(PilP) 		4 LEU M 143
LEU M 146
TYR M 125
MET M  95
 None
 1.18A 5hbsA-4av2M:
undetectable		 5hbsA-4av2M:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eco UNCHARACTERIZED
PROTEIN

(Bacteroides
eggerthii) 		no annotation 4 LEU A 476
LEU A 354
TYR A 480
GLN A 405
 None
 1.01A 5hbsA-4ecoA:
undetectable		 5hbsA-4ecoA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f92 U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		4 LEU B 897
LEU B 409
TYR B 936
GLN B 418
 None
 1.14A 5hbsA-4f92B:
undetectable		 5hbsA-4f92B:
6.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fys AMINOPEPTIDASE N

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 LEU A 521
LEU A 484
THR A 544
TYR A 514
 None
 1.10A 5hbsA-4fysA:
undetectable		 5hbsA-4fysA:
8.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gmf YERSINIABACTIN
BIOSYNTHETIC PROTEIN
YBTU

(Yersinia
enterocolitica) 		PF01408
(GFO_IDH_MocA) 		4 LEU A 228
LEU A 138
THR A 131
TYR A 128
 None
 0.91A 5hbsA-4gmfA:
1.8		 5hbsA-4gmfA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h19 MANDELATE RACEMASE

(Agrobacterium
fabrum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 326
LEU A 316
THR A 280
GLN A 256
 None
 1.13A 5hbsA-4h19A:
0.2		 5hbsA-4h19A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h6y FERM, RHOGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00169
(PH)
PF00621
(RhoGEF) 		4 LEU A 606
LEU A 599
THR A 551
GLN A 694
 None
 1.07A 5hbsA-4h6yA:
undetectable		 5hbsA-4h6yA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hi2 ACYLPHOSPHATASE

(Vibrio cholerae) 		PF00708
(Acylphosphatase) 		4 LEU A  58
LEU A  28
TYR A  35
GLN A  15
 None
 1.19A 5hbsA-4hi2A:
undetectable		 5hbsA-4hi2A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k17 LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 16A

(Mus musculus) 		PF13516
(LRR_6) 		4 LEU A 386
LEU A 379
THR A 375
MET A 357
 None
 0.87A 5hbsA-4k17A:
undetectable		 5hbsA-4k17A:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lrs 4-HYDROXY-2-OXOVALER
ATE ALDOLASE

(Thermomonospora
curvata) 		PF00682
(HMGL-like)
PF07836
(DmpG_comm) 		4 LEU A 155
LEU A 146
TYR A 171
MET A 162
 None
 1.12A 5hbsA-4lrsA:
undetectable		 5hbsA-4lrsA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n5i ESTERASE/LIPASE

(Lactobacillus
rhamnosus) 		PF07859
(Abhydrolase_3) 		4 LEU X 142
LEU X 154
GLN X  50
MET X 102
 None
 1.08A 5hbsA-4n5iX:
undetectable		 5hbsA-4n5iX:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nkr MOLYBDOPTERIN-GUANIN
E DINUCLEOTIDE
BIOSYNTHESIS PROTEIN
B

(Bacillus
subtilis) 		PF03205
(MobB) 		4 LEU A  31
LEU A  39
THR A 103
TYR A  98
 None
 1.20A 5hbsA-4nkrA:
undetectable		 5hbsA-4nkrA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nmn REPLICATIVE DNA
HELICASE

(Aquifex
aeolicus) 		PF00772
(DnaB)
PF03796
(DnaB_C) 		4 LEU A 272
LEU A 247
THR A 433
TYR A 432
 None
None
ADP  A1001 (-4.7A)
None
 0.95A 5hbsA-4nmnA:
0.9		 5hbsA-4nmnA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ol0 TRANSPORTIN-3

(Homo sapiens) 		PF08389
(Xpo1) 		4 LEU B 143
LEU B 184
THR B 179
TYR B 176
 None
 1.13A 5hbsA-4ol0B:
undetectable		 5hbsA-4ol0B:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p7l POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE

(Escherichia
coli) 		PF14883
(GHL13) 		4 LEU A 650
LEU A 339
TYR A 325
GLN A 330
 None
 0.99A 5hbsA-4p7lA:
undetectable		 5hbsA-4p7lA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pbv NT-3 GROWTH FACTOR
RECEPTOR
PROTEIN-TYROSINE
PHOSPHATASE
CRYPALPHA1 ISOFORM

(Gallus gallus;
Gallus gallus) 		PF00047
(ig)
PF13855
(LRR_8)
PF16920
(TPKR_C2)
PF07679
(I-set)
PF13927
(Ig_3) 		4 LEU A 139
LEU A  94
TRP A 144
GLN C  75
 None
 0.78A 5hbsA-4pbvA:
undetectable		 5hbsA-4pbvA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qgs ALCOHOL
DEHYDROGENASE YQHD

(Escherichia
coli) 		PF00465
(Fe-ADH) 		4 LEU A  90
LEU A  98
THR A 138
TYR A 179
 None
 1.18A 5hbsA-4qgsA:
undetectable		 5hbsA-4qgsA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgy ESTERASE

(uncultured
bacterium FLS12) 		PF00756
(Esterase) 		4 LEU A 193
LEU A 134
THR A  86
GLN A 173
 None
 1.19A 5hbsA-4rgyA:
undetectable		 5hbsA-4rgyA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rlv ANKYRIN-1, ANKYRIN-2

(Homo sapiens;
Mus musculus) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13637
(Ank_4)
PF13857
(Ank_5) 		4 LEU A2182
LEU A2149
THR A2132
TYR A2135
 None
 0.99A 5hbsA-4rlvA:
undetectable		 5hbsA-4rlvA:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rsl FRUCTOSYL PEPTIDE
OXIDASE

(Penicillium
terrenum) 		PF01266
(DAO) 		4 LEU A  63
LEU A 152
THR A 124
GLN A  80
 None
 1.14A 5hbsA-4rslA:
undetectable		 5hbsA-4rslA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ryk LMO0325 PROTEIN

(Listeria
monocytogenes) 		PF01381
(HTH_3) 		4 LEU A 181
LEU A 200
THR A 205
GLN A 247
 None
 1.03A 5hbsA-4rykA:
undetectable		 5hbsA-4rykA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus musculus) 		PF00069
(Pkinase) 		4 LEU B  75
LEU B 167
TYR B 140
GLN B 202
 39G  B 401 (-4.3A)
39G  B 401 (-3.6A)
None
None
 1.19A 5hbsA-4tyhB:
undetectable		 5hbsA-4tyhB:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xai MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TAILLESS
ORTHOLOG

(Escherichia
coli;
Tribolium
castaneum) 		PF00104
(Hormone_recep)
PF13416
(SBP_bac_8) 		4 LEU A1223
LEU A1230
THR A1308
GLN A1337
 None
 1.18A 5hbsA-4xaiA:
undetectable		 5hbsA-4xaiA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yn5 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE

(Bacillus sp.
JAMB750) 		PF02156
(Glyco_hydro_26) 		4 LEU A 185
LEU A 172
TYR A 235
MET A 149
 None
 1.11A 5hbsA-4yn5A:
undetectable		 5hbsA-4yn5A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxk SIALIDASE A

(Streptococcus
pneumoniae) 		PF02973
(Sialidase) 		4 LEU A 170
THR A 193
TYR A 188
GLN A 203
 None
 1.06A 5hbsA-4zxkA:
undetectable		 5hbsA-4zxkA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a29 EXOPOLYGALACTURONATE
LYASE

(Vibrio
vulnificus) 		PF06917
(Pectate_lyase_2) 		4 LEU A 414
LEU A 466
THR A 527
GLN A 477
 None
 1.10A 5hbsA-5a29A:
undetectable		 5hbsA-5a29A:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c6g AGR133CP
SISTER CHROMATID
COHESION PROTEIN 2

(Eremothecium
gossypii;
Eremothecium
gossypii) 		PF10345
(Cohesin_load)
no annotation 		4 LEU B  19
LEU A 584
GLN A 609
MET A 612
 None
 0.99A 5hbsA-5c6gB:
undetectable		 5hbsA-5c6gB:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF

(Serratia sp.
FS14) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		4 LEU A 726
LEU A 640
THR A 668
GLN A  72
 None
 1.20A 5hbsA-5cioA:
undetectable		 5hbsA-5cioA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cz1 INTEGRASE

(Mouse mammary
tumor virus) 		PF00665
(rve) 		4 LEU A 188
LEU A 168
THR A  67
GLN A 154
 None
 1.15A 5hbsA-5cz1A:
1.1		 5hbsA-5cz1A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ee5 BREFELDIN
A-INHIBITED GUANINE
NUCLEOTIDE-EXCHANGE
PROTEIN 1

(Homo sapiens) 		PF16213
(DCB) 		4 LEU A 126
LEU A 103
LYS A   8
TYR A  80
 None
 0.97A 5hbsA-5ee5A:
undetectable		 5hbsA-5ee5A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey8 ACYL-COA SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00501
(AMP-binding) 		4 LEU A 267
LEU A 311
THR A 237
GLN A  86
 None
5SV  A 701 (-4.2A)
5SV  A 701 (-3.3A)
None
 1.18A 5hbsA-5ey8A:
undetectable		 5hbsA-5ey8A:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsw RNA DEPENDENT RNA
POLYMERASE QDE-1

(Thielavia
terrestris) 		PF05183
(RdRP) 		4 LEU A 276
LEU A 396
THR A 301
GLN A 356
 None
 0.94A 5hbsA-5fswA:
undetectable		 5hbsA-5fswA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hsi PUTATIVE
DECARBOXYLASE

(Lactobacillus
brevis) 		PF00282
(Pyridoxal_deC) 		4 LEU A 231
LEU A 175
THR A 200
GLN A 317
 None
 1.14A 5hbsA-5hsiA:
undetectable		 5hbsA-5hsiA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxa ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)

(Paraburkholderia
xenovorans) 		PF00982
(Glyco_transf_20) 		4 LEU A 302
LEU A 279
THR A 367
GLN A 417
 None
 0.82A 5hbsA-5hxaA:
undetectable		 5hbsA-5hxaA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1

(Homo sapiens) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 LEU A1095
LEU A1127
GLN A1422
MET A 868
 None
 1.19A 5hbsA-5iy9A:
undetectable		 5hbsA-5iy9A:
7.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j47 LARGE T ANTIGEN

(Human
polyomavirus 2) 		PF06431
(Polyoma_lg_T_C) 		4 LEU A 627
LEU A 385
THR A 575
GLN A 571
 None
 1.16A 5hbsA-5j47A:
undetectable		 5hbsA-5j47A:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jtf PUTATIVE
PHOSPHINOTHRICIN
N-ACETYLTRANSFERASE

(Pseudomonas
putida) 		PF13420
(Acetyltransf_4) 		4 LEU A 111
LEU A 176
THR A  50
TYR A  70
 None
 1.01A 5hbsA-5jtfA:
undetectable		 5hbsA-5jtfA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l5n PLEXIN-A4

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI)
PF01833
(TIG) 		4 LEU A 444
LEU A 493
THR A 471
GLN A 511
 LEU  A 444 ( 0.5A)
LEU  A 493 ( 0.5A)
THR  A 471 ( 0.8A)
GLN  A 511 ( 0.6A)
 1.19A 5hbsA-5l5nA:
undetectable		 5hbsA-5l5nA:
7.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6u BETA-MANNOSIDASE

(Dictyoglomus
thermophilum) 		PF00703
(Glyco_hydro_2)
PF02837
(Glyco_hydro_2_N) 		5 LEU A 343
LEU A 619
THR A 519
TYR A 616
TRP A 605
 None
 1.38A 5hbsA-5n6uA:
undetectable		 5hbsA-5n6uA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u0s MEDIATOR COMPLEX
SUBUNIT 8
MEDIATOR COMPLEX
SUBUNIT 18

(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe) 		PF10232
(Med8)
PF09637
(Med18) 		4 LEU H 188
LEU R 167
TYR R   5
MET H 195
 None
 1.09A 5hbsA-5u0sH:
undetectable		 5hbsA-5u0sH:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w66 RNA POLYMERASE
I-SPECIFIC
TRANSCRIPTION
INITIATION FACTOR
RRN7

(Saccharomyces
cerevisiae) 		no annotation 4 LEU P 487
THR P 270
TYR P 309
GLN P 250
 None
 1.09A 5hbsA-5w66P:
undetectable		 5hbsA-5w66P:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtc NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
5
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4L

(Homo sapiens;
Homo sapiens;
Homo sapiens) 		no annotation
no annotation
no annotation 		4 LEU i  75
LEU k  46
THR k  51
GLN h  25
 None
 1.20A 5hbsA-5xtci:
undetectable		 5hbsA-5xtci:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtd NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1

(Homo sapiens) 		PF15879
(MWFE) 		4 LEU s 162
LEU s 103
THR s 108
MET s 233
 None
 1.15A 5hbsA-5xtds:
undetectable		 5hbsA-5xtds:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y1a -

(-) 		no annotation 4 LEU A 128
LEU A 250
TYR A 162
GLN A  54
 None
 1.11A 5hbsA-5y1aA:
undetectable		 5hbsA-5y1aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y4d ANKYRIN-1,ANKYRIN-2,
ANKYRIN-2

(Homo sapiens;
Mus musculus) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13637
(Ank_4) 		4 LEU A2182
LEU A2149
THR A2132
TYR A2135
 None
 1.08A 5hbsA-5y4dA:
undetectable		 5hbsA-5y4dA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4

(Pseudoxanthomonas
mexicana) 		no annotation 4 LEU A 622
LEU A 561
THR A 534
TYR A 527
 None
None
None
PRO  A 802 (-4.7A)
 1.18A 5hbsA-5yp3A:
undetectable		 5hbsA-5yp3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bcb RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 18

(Mus musculus) 		no annotation 4 LEU A 363
LEU A 335
THR A 315
TYR A 377
 None
 1.15A 5hbsA-6bcbA:
undetectable		 5hbsA-6bcbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ei3 PROTON-DEPENDENT
OLIGOPEPTIDE
TRANSPORTER FAMILY
PROTEIN

(Xanthomonas
campestris) 		no annotation 4 LEU A 168
LEU A 356
THR A 422
TYR A 418
 78M  A 610 ( 4.6A)
78M  A 613 ( 4.9A)
None
None
 1.08A 5hbsA-6ei3A:
undetectable		 5hbsA-6ei3A:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eu2 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC3

(Saccharomyces
cerevisiae) 		no annotation 4 LEU O  79
LEU O  98
TYR O 121
GLN O 108
 None
 0.91A 5hbsA-6eu2O:
undetectable		 5hbsA-6eu2O:
undetectable