SIMILAR PATTERNS OF AMINO ACIDS FOR 5H8T_A_RTLA201_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ggl PROTEIN (CELLULAR
RETINOL-BINDING
PROTEIN III)

(Homo sapiens) 		PF00061
(Lipocalin) 		4 LEU A  36
LYS A  40
THR A  53
TRP A 106
 None
 0.40A 5h8tA-1gglA:
23.4		 5h8tA-1gglA:
53.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kqx CELLULAR
RETINOL-BINDING
PROTEIN

(Danio rerio) 		PF00061
(Lipocalin) 		4 LYS A  40
THR A  53
TRP A 106
GLN A 108
 None
 0.46A 5h8tA-1kqxA:
24.2		 5h8tA-1kqxA:
58.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lpj RETINOL-BINDING
PROTEIN IV, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		5 LEU A  36
LYS A  40
THR A  53
TRP A 106
MET A 119
 None
 0.61A 5h8tA-1lpjA:
24.0		 5h8tA-1lpjA:
55.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m7j D-AMINOACYLASE

(Alcaligenes
faecalis) 		PF07969
(Amidohydro_3) 		4 LEU A 115
THR A  68
GLN A  86
MET A  80
 None
 1.15A 5h8tA-1m7jA:
undetectable		 5h8tA-1m7jA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m7s CATALASE

(Pseudomonas
syringae) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 LEU A 350
LYS A 303
THR A 302
GLN A 436
 HEM  A 600 (-4.2A)
None
None
None
 1.30A 5h8tA-1m7sA:
2.7		 5h8tA-1m7sA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qnz 0.5B ANTIBODY (HEAVY
CHAIN)
0.5B ANTIBODY (LIGHT
CHAIN)

(Mus musculus;
Mus musculus) 		PF07686
(V-set)
PF07686
(V-set) 		4 LEU L  50
TRP H 148
GLN H 118
MET H 149
 None
 1.41A 5h8tA-1qnzL:
0.0		 5h8tA-1qnzL:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r3n BETA-ALANINE
SYNTHASE

(Lachancea
kluyveri) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 LEU A 128
THR A  38
GLN A  45
MET A  73
 None
 1.32A 5h8tA-1r3nA:
0.0		 5h8tA-1r3nA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rhc F420-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Methanoculleus
thermophilus) 		PF00296
(Bac_luciferase) 		4 LEU A 170
THR A  74
GLN A  52
MET A  57
 None
 1.35A 5h8tA-1rhcA:
0.0		 5h8tA-1rhcA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z5v TUBULIN GAMMA-1
CHAIN

(Homo sapiens) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		4 LEU A  66
THR A   7
GLN A 167
MET A 236
 None
 1.46A 5h8tA-1z5vA:
undetectable		 5h8tA-1z5vA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0i 432AA LONG
HYPOTHETICAL
DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE

(Sulfurisphaera
tokodaii) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		4 LEU A 319
THR A 289
TRP A 368
GLN A 371
 None
 1.24A 5h8tA-2e0iA:
undetectable		 5h8tA-2e0iA:
16.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rcq RETINOL-BINDING
PROTEIN II, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		4 LYS A  40
THR A  53
TRP A 106
GLN A 108
 None
 0.51A 5h8tA-2rcqA:
23.8		 5h8tA-2rcqA:
51.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbz CYTOCHROME P450-SU1

(Streptomyces
griseolus) 		PF00067
(p450) 		4 LEU A 346
THR A  55
TRP A  52
GLN A 308
 None
 1.49A 5h8tA-2zbzA:
undetectable		 5h8tA-2zbzA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 LEU A 183
TRP A 504
GLN A 489
MET A 333
 None
None
FAB  A 701 (-3.5A)
FAB  A 701 (-4.0A)
 1.47A 5h8tA-3e9yA:
undetectable		 5h8tA-3e9yA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF14710
(Nitr_red_alph_N) 		4 LEU A 629
LYS A1193
THR A1195
MET A 552
 None
 1.47A 5h8tA-3egwA:
0.0		 5h8tA-3egwA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qc5 PLATELET BINDING
PROTEIN GSPB

(Streptococcus
gordonii) 		no annotation 4 LEU X 373
THR X 382
GLN X 288
MET X 263
 None
 1.08A 5h8tA-3qc5X:
1.0		 5h8tA-3qc5X:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG

(Mus musculus) 		PF14631
(FancD2) 		4 LEU B 133
THR B 102
GLN B 157
MET B 170
 None
 1.22A 5h8tA-3s4wB:
undetectable		 5h8tA-3s4wB:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a7k ALDOS-2-ULOSE
DEHYDRATASE

(Phanerochaete
chrysosporium) 		no annotation 4 LEU A 328
TRP A 370
GLN A 365
MET A 356
 None
 1.31A 5h8tA-4a7kA:
2.3		 5h8tA-4a7kA:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z5y COENZYME PQQ
SYNTHESIS PROTEIN B

(Pseudomonas
putida) 		PF12706
(Lactamase_B_2) 		4 LEU A  97
TRP A  51
GLN A   4
MET A  70
 None
 1.44A 5h8tA-4z5yA:
0.0		 5h8tA-4z5yA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zaa FDC1

(Aspergillus
niger) 		PF01977
(UbiD) 		4 LEU A 330
LYS A 391
TRP A 166
GLN A 194
 None
FZZ  A 602 ( 2.6A)
None
None
 1.36A 5h8tA-4zaaA:
undetectable		 5h8tA-4zaaA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zad FDC1

(Candida
dubliniensis) 		PF01977
(UbiD) 		4 LEU A 337
LYS A 404
TRP A 172
GLN A 200
 None
4LU  A 603 (-2.6A)
None
None
 1.42A 5h8tA-4zadA:
undetectable		 5h8tA-4zadA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9a POLYMERASE BASIC
PROTEIN 2

(Influenza C
virus) 		PF00604
(Flu_PB2) 		4 LEU C 536
THR C 532
GLN C 446
MET C 412
 None
 1.41A 5h8tA-5d9aC:
undetectable		 5h8tA-5d9aC:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exr DNA POLYMERASE ALPHA
SUBUNIT B

(Homo sapiens) 		PF04042
(DNA_pol_E_B)
PF08418
(Pol_alpha_B_N) 		4 LEU D 477
THR D 472
GLN D 437
MET D 518
 None
 1.28A 5h8tA-5exrD:
undetectable		 5h8tA-5exrD:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jpn COMPLEMENT C4-A

(Homo sapiens) 		PF00207
(A2M)
PF01821
(ANATO)
PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl) 		4 LEU B1132
THR B1234
TRP B1261
GLN B1222
 None
 1.36A 5h8tA-5jpnB:
undetectable		 5h8tA-5jpnB:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z0u NEOPULLULANASE 1

(Thermoactinomyces
vulgaris) 		no annotation 4 LEU A 449
THR A 421
TRP A 398
GLN A 434
 None
 1.40A 5h8tA-5z0uA:
undetectable		 5h8tA-5z0uA:
undetectable