SIMILAR PATTERNS OF AMINO ACIDS FOR 5H8T_A_RTLA201_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b3b PROTEIN (GLUTAMATE
DEHYDROGENASE)

(Thermotoga
maritima) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 LEU A 178
ILE A 130
SER A 160
TYR A 155
ILE A 152
 None
 0.99A 5h8tA-1b3bA:
undetectable		 5h8tA-1b3bA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dcu FRUCTOSE-1,6-BISPHOS
PHATASE

(Pisum sativum) 		PF00316
(FBPase) 		5 LEU A 184
ALA A 186
ILE A 197
TYR A 189
ILE A 312
 None
 1.03A 5h8tA-1dcuA:
undetectable		 5h8tA-1dcuA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dof ADENYLOSUCCINATE
LYASE

(Pyrobaculum
aerophilum) 		PF00206
(Lyase_1) 		5 PHE A  19
LEU A 112
ALA A 111
ILE A  99
ARG A 109
 None
 1.16A 5h8tA-1dofA:
undetectable		 5h8tA-1dofA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ecg GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Escherichia
coli) 		PF00156
(Pribosyltran)
PF13522
(GATase_6) 		5 PHE A 461
ALA A 396
ILE A 453
ARG A 275
TYR A 256
 None
 1.18A 5h8tA-1ecgA:
undetectable		 5h8tA-1ecgA:
12.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ggl PROTEIN (CELLULAR
RETINOL-BINDING
PROTEIN III)

(Homo sapiens) 		PF00061
(Lipocalin) 		7 TYR A  19
LEU A  20
ALA A  33
SER A  55
ARG A  58
TYR A  60
LEU A 117
 None
 1.03A 5h8tA-1gglA:
23.4		 5h8tA-1gglA:
53.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htq GLUTAMINE SYNTHETASE

(Mycobacterium
tuberculosis) 		PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N) 		5 TYR A 114
LEU A 115
ALA A 124
ILE A 386
ILE A 120
 None
 1.02A 5h8tA-1htqA:
undetectable		 5h8tA-1htqA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j93 UROPORPHYRINOGEN
DECARBOXYLASE

(Nicotiana
tabacum) 		PF01208
(URO-D) 		5 LEU A 219
ALA A 216
ILE A  92
ILE A 172
LEU A  84
 None
 1.16A 5h8tA-1j93A:
undetectable		 5h8tA-1j93A:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k32 TRICORN PROTEASE

(Thermoplasma
acidophilum) 		PF03572
(Peptidase_S41)
PF07676
(PD40)
PF14684
(Tricorn_C1)
PF14685
(Tricorn_PDZ) 		5 PHE A 140
LEU A 146
ALA A  94
ARG A  96
LEU A 184
 None
 1.18A 5h8tA-1k32A:
undetectable		 5h8tA-1k32A:
8.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lpj RETINOL-BINDING
PROTEIN IV, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		7 PHE A  16
TYR A  19
ALA A  33
ILE A  51
SER A  55
ARG A  58
LEU A 117
 None
 0.98A 5h8tA-1lpjA:
24.0		 5h8tA-1lpjA:
55.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mi8 DNAB INTEIN

(Synechocystis
sp. PCC 6803) 		PF14890
(Intein_splicing) 		5 PHE A  75
LEU A  84
ALA A  69
SER A   6
LEU A  95
 None
 1.16A 5h8tA-1mi8A:
undetectable		 5h8tA-1mi8A:
18.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mx8 CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO

(Rattus
norvegicus) 		PF00061
(Lipocalin) 		6 LEU A  23
ILE A  51
ARG A  58
TYR A  60
MET A  62
ILE A  77
 None
RTL  A 135 ( 4.6A)
None
RTL  A 135 ( 4.6A)
RTL  A 135 (-2.9A)
RTL  A 135 (-3.5A)
 1.49A 5h8tA-1mx8A:
20.1		 5h8tA-1mx8A:
92.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mx8 CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO

(Rattus
norvegicus) 		PF00061
(Lipocalin) 		10 PHE A  16
TYR A  19
LEU A  20
LEU A  29
ALA A  33
ILE A  51
SER A  55
ARG A  58
MET A  62
ILE A  77
 RTL  A 135 ( 4.6A)
None
RTL  A 135 ( 4.7A)
RTL  A 135 (-3.8A)
RTL  A 135 ( 3.9A)
RTL  A 135 ( 4.6A)
RTL  A 135 ( 4.4A)
None
RTL  A 135 (-2.9A)
RTL  A 135 (-3.5A)
 1.00A 5h8tA-1mx8A:
20.1		 5h8tA-1mx8A:
92.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mx8 CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO

(Rattus
norvegicus) 		PF00061
(Lipocalin) 		10 PHE A  16
TYR A  19
LEU A  29
ALA A  33
ILE A  51
SER A  55
ARG A  58
TYR A  60
MET A  62
ILE A  77
 RTL  A 135 ( 4.6A)
None
RTL  A 135 (-3.8A)
RTL  A 135 ( 3.9A)
RTL  A 135 ( 4.6A)
RTL  A 135 ( 4.4A)
None
RTL  A 135 ( 4.6A)
RTL  A 135 (-2.9A)
RTL  A 135 (-3.5A)
 1.00A 5h8tA-1mx8A:
20.1		 5h8tA-1mx8A:
92.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ox4 IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
HISHF

(Saccharomyces
cerevisiae) 		PF00117
(GATase)
PF00977
(His_biosynth) 		5 PHE B  56
LEU B  60
LEU B 102
ALA B  88
LEU B  14
 None
 0.96A 5h8tA-1ox4B:
undetectable		 5h8tA-1ox4B:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pg5 ASPARTATE
CARBAMOYLTRANSFERASE

(Sulfolobus
acidocaldarius) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		6 LEU A 168
LEU A 194
ALA A 189
ILE A 211
SER A 183
TYR A 180
 None
 1.21A 5h8tA-1pg5A:
undetectable		 5h8tA-1pg5A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r20 ULTRASPIRACLE
PROTEIN
ECDYSONE RECEPTOR

(Heliothis
virescens;
Heliothis
virescens) 		PF00104
(Hormone_recep)
PF00104
(Hormone_recep) 		5 PHE D 487
LEU D 491
ALA A 415
ILE D 298
ILE D 443
 None
 1.00A 5h8tA-1r20D:
undetectable		 5h8tA-1r20D:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1to9 THI-4 PROTEIN

(Bacillus
subtilis) 		PF03070
(TENA_THI-4) 		5 ALA B 212
SER B 106
TYR B 112
MET B 116
LEU B  48
 None
None
None
None
HMH  B 302 ( 4.9A)
 1.08A 5h8tA-1to9B:
undetectable		 5h8tA-1to9B:
19.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tow FATTY ACID-BINDING
PROTEIN, ADIPOCYTE

(Homo sapiens) 		PF00061
(Lipocalin) 		5 PHE A  16
TYR A  19
ALA A  33
ILE A  51
SER A  55
 CRZ  A 501 (-4.5A)
None
CRZ  A 501 ( 4.1A)
None
CRZ  A 501 ( 4.8A)
 0.80A 5h8tA-1towA:
20.4		 5h8tA-1towA:
35.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tue REPLICATION PROTEIN
E1

(Alphapapillomavirus
7) 		PF00519
(PPV_E1_C) 		5 PHE A 463
LEU A 453
ILE A 433
ILE A 449
LEU A 627
 None
 1.05A 5h8tA-1tueA:
undetectable		 5h8tA-1tueA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v40 GLUTATHIONE-REQUIRIN
G PROSTAGLANDIN D
SYNTHASE

(Homo sapiens) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 ALA A  15
ILE A 184
ARG A  12
ILE A 155
LEU A  77
 None
 1.16A 5h8tA-1v40A:
undetectable		 5h8tA-1v40A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkh PUTATIVE SERINE
HYDROLASE

(Saccharomyces
cerevisiae) 		PF07859
(Abhydrolase_3) 		6 PHE A 174
TYR A 181
LEU A 156
ILE A  35
ILE A 153
LEU A  85
 None
 1.22A 5h8tA-1vkhA:
undetectable		 5h8tA-1vkhA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ypx PUTATIVE VITAMIN-B12
INDEPENDENT
METHIONINE SYNTHASE
FAMILY PROTEIN

(Listeria
monocytogenes) 		PF01717
(Meth_synt_2) 		5 LEU A 165
LEU A  79
ALA A 168
ILE A 266
MET A 236
 None
 1.05A 5h8tA-1ypxA:
undetectable		 5h8tA-1ypxA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z5x ECDYSONE RECEPTOR
LIGAND BINDING
DOMAIN
ULTRASPIRACLE
PROTEIN (USP) A
HOMOLOGUE OF RXR

(Bemisia tabaci;
Bemisia tabaci) 		PF00104
(Hormone_recep)
PF00104
(Hormone_recep) 		5 PHE E 373
LEU E 377
ALA U 451
ILE E 188
ILE E 331
 None
 1.16A 5h8tA-1z5xE:
undetectable		 5h8tA-1z5xE:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b7h HEMOGLOBIN ALPHA
CHAIN

(Cerdocyon thous) 		PF00042
(Globin) 		5 LEU A   2
LEU A  76
ALA A 131
SER A 102
ILE A  10
 None
 1.03A 5h8tA-2b7hA:
undetectable		 5h8tA-2b7hA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo sapiens) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		5 TYR A 394
LEU A 468
ALA A 368
ILE A 127
SER A 645
 None
PAQ  A 471 ( 3.4A)
None
None
None
 1.13A 5h8tA-2c11A:
undetectable		 5h8tA-2c11A:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4m GLYCOGEN
PHOSPHORYLASE

(Corynebacterium
callunae) 		PF00343
(Phosphorylase) 		5 PHE A 263
LEU A 177
ALA A 267
TYR A 191
ILE A 189
 None
 1.15A 5h8tA-2c4mA:
undetectable		 5h8tA-2c4mA:
10.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2cbr PROTEIN (CRABP-I)

(Bos taurus) 		PF00061
(Lipocalin) 		5 PHE A  15
LEU A  19
ALA A  32
ILE A  52
LEU A 120
 None
None
A80  A 201 ( 4.1A)
None
None
 0.55A 5h8tA-2cbrA:
19.8		 5h8tA-2cbrA:
41.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eno SYNAPTOJANIN-2-BINDI
NG PROTEIN

(Homo sapiens) 		PF00595
(PDZ) 		5 PHE A  92
LEU A 101
LEU A  66
TYR A  50
LEU A  83
 None
 1.11A 5h8tA-2enoA:
undetectable		 5h8tA-2enoA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hor ALLIIN LYASE 1

(Allium sativum) 		PF04863
(EGF_alliinase)
PF04864
(Alliinase_C) 		5 PHE A 260
LEU A 294
ILE A 265
ILE A 109
LEU A 135
 None
 1.12A 5h8tA-2horA:
undetectable		 5h8tA-2horA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j4h DEOXYCYTIDINE
TRIPHOSPHATE
DEAMINASE

(Escherichia
coli) 		PF00692
(dUTPase) 		5 PHE A 160
LEU A  17
ILE A 155
ILE A  19
LEU A 107
 None
 1.11A 5h8tA-2j4hA:
undetectable		 5h8tA-2j4hA:
17.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q9s FATTY ACID-BINDING
PROTEIN

(Mus musculus) 		PF00061
(Lipocalin) 		5 PHE A  16
TYR A  19
ALA A  33
ILE A  51
SER A  55
 None
None
EIC  A 601 (-3.5A)
None
None
 0.74A 5h8tA-2q9sA:
20.1		 5h8tA-2q9sA:
31.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qki COMPLEMENT C3

(Homo sapiens) 		PF01759
(NTR)
PF07677
(A2M_recep) 		5 ALA C1376
ILE C1407
TYR C1425
ILE C1380
LEU C1437
 None
 1.11A 5h8tA-2qkiC:
undetectable		 5h8tA-2qkiC:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qpt EH DOMAIN-CONTAINING
PROTEIN-2

(Mus musculus) 		PF00350
(Dynamin_N)
PF12763
(EF-hand_4)
PF16880
(EHD_N) 		5 TYR A 233
ALA A 221
ILE A 214
TYR A 253
LEU A 240
 None
 1.12A 5h8tA-2qptA:
undetectable		 5h8tA-2qptA:
12.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rcq RETINOL-BINDING
PROTEIN II, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		5 PHE A  16
TYR A  19
ALA A  33
SER A  55
LEU A 117
 None
 0.57A 5h8tA-2rcqA:
23.8		 5h8tA-2rcqA:
51.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vfw SHORT-CHAIN
Z-ISOPRENYL
DIPHOSPHATE
SYNTHETASE

(Mycobacterium
tuberculosis) 		PF01255
(Prenyltransf) 		5 LEU A 250
LEU A  31
ALA A  75
ILE A  65
ILE A  35
 None
 1.15A 5h8tA-2vfwA:
undetectable		 5h8tA-2vfwA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w8m ORF D212

(Sulfolobus
spindle-shaped
virus 8) 		PF12187
(VirArc_Nuclease) 		5 PHE A 203
TYR A 206
LEU A 207
ALA A  86
TYR A  68
 None
 1.05A 5h8tA-2w8mA:
undetectable		 5h8tA-2w8mA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xn6 THYROXINE-BINDING
GLOBULIN

(Homo sapiens) 		PF00079
(Serpin) 		5 LEU A 300
LEU A 350
ALA A 329
ILE A  46
ILE A  53
 None
 1.17A 5h8tA-2xn6A:
undetectable		 5h8tA-2xn6A:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1n NDP-SUGAR EPIMERASE

(Thermoplasma
volcanium) 		PF01370
(Epimerase) 		5 LEU A 205
LEU A 199
ALA A 270
ILE A  11
SER A  74
 None
None
None
NAD  A3001 (-3.9A)
None
 1.14A 5h8tA-3a1nA:
undetectable		 5h8tA-3a1nA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e38 TWO-DOMAIN PROTEIN
CONTAINING PREDICTED
PHP-LIKE
METAL-DEPENDENT
PHOSPHOESTERASE

(Bacteroides
vulgatus) 		PF16392
(DUF5001) 		5 PHE A 344
LEU A 304
LEU A 302
ILE A 294
LEU A 363
 None
 1.03A 5h8tA-3e38A:
undetectable		 5h8tA-3e38A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eaf ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN

(Aeropyrum
pernix) 		PF13458
(Peripla_BP_6) 		6 TYR A 382
LEU A 365
LEU A 361
ALA A 344
ILE A 375
ILE A 144
 None
 1.39A 5h8tA-3eafA:
undetectable		 5h8tA-3eafA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ek5 URIDYLATE KINASE

(Xanthomonas
campestris) 		PF00696
(AA_kinase) 		5 LEU A   4
ALA A  44
ILE A 130
ILE A   9
LEU A  34
 None
 0.99A 5h8tA-3ek5A:
undetectable		 5h8tA-3ek5A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3emu LEUCINE RICH REPEAT
AND PHOSPHATASE
DOMAIN CONTAINING
PROTEIN

(Entamoeba
histolytica) 		PF00782
(DSPc) 		5 LEU A 372
LEU A 444
ALA A 406
ILE A 376
LEU A 360
 None
 1.12A 5h8tA-3emuA:
undetectable		 5h8tA-3emuA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fmc PUTATIVE
SUCCINYLGLUTAMATE
DESUCCINYLASE /
ASPARTOACYLASE

(Shewanella
amazonensis) 		PF04952
(AstE_AspA) 		5 PHE A 193
LEU A 238
ALA A 189
ILE A 166
LEU A  55
 None
 1.10A 5h8tA-3fmcA:
undetectable		 5h8tA-3fmcA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gi8 UNCHARACTERIZED
PROTEIN MJ0609

(Methanocaldococcus
jannaschii) 		PF13520
(AA_permease_2) 		5 LEU C 260
ALA C 243
ILE C 231
TYR C 236
LEU C 159
 None
 1.01A 5h8tA-3gi8C:
undetectable		 5h8tA-3gi8C:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hul HOMOSERINE KINASE

(Listeria
monocytogenes) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 LEU A 265
ILE A 196
TYR A 238
MET A 201
LEU A  21
 None
 1.09A 5h8tA-3hulA:
undetectable		 5h8tA-3hulA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I)
PF01590
(GAF)
PF13185
(GAF_2) 		5 PHE A 404
LEU A 396
ALA A 400
ILE A 515
ILE A 542
 None
 1.16A 5h8tA-3ibjA:
undetectable		 5h8tA-3ibjA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iyl VP1

(Aquareovirus C) 		PF06016
(Reovirus_L2) 		5 LEU W 618
LEU W 566
ALA W 606
ILE W 537
TYR W 518
 None
 1.14A 5h8tA-3iylW:
undetectable		 5h8tA-3iylW:
6.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l09 PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Jannaschia sp.
CCS1) 		PF07848
(PaaX) 		5 PHE A 203
LEU A  47
ILE A 102
SER A  35
LEU A 245
 None
 1.06A 5h8tA-3l09A:
undetectable		 5h8tA-3l09A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lu2 LMO2462 PROTEIN

(Listeria
monocytogenes) 		PF01244
(Peptidase_M19) 		5 LEU A  36
ALA A 275
ILE A 256
SER A 260
LEU A 285
 None
 1.15A 5h8tA-3lu2A:
undetectable		 5h8tA-3lu2A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nh9 ATP-BINDING CASSETTE
SUB-FAMILY B MEMBER
6, MITOCHONDRIAL

(Homo sapiens) 		PF00005
(ABC_tran) 		5 LEU A 583
ILE A 632
ARG A 648
ILE A 654
LEU A 749
 None
 1.08A 5h8tA-3nh9A:
undetectable		 5h8tA-3nh9A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8q SHIKIMATE
5-DEHYDROGENASE I
ALPHA

(Vibrio cholerae) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		5 PHE B 226
ALA B 230
ILE B 150
TYR B 185
ILE B 207
 None
 0.86A 5h8tA-3o8qB:
undetectable		 5h8tA-3o8qB:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3otr ENOLASE

(Toxoplasma
gondii) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 PHE A 392
LEU A 396
LEU A 354
ILE A  89
ILE A 366
 None
 1.13A 5h8tA-3otrA:
undetectable		 5h8tA-3otrA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppb PUTATIVE TETR FAMILY
TRANSCRIPTION
REGULATOR

(Shewanella
loihica) 		PF00440
(TetR_N) 		5 PHE A 187
LEU A  81
ALA A  85
MET A 124
ILE A 135
 PG4  A 216 (-4.7A)
None
PG4  A 216 ( 4.1A)
None
None
 1.12A 5h8tA-3ppbA:
undetectable		 5h8tA-3ppbA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vcy UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Aliivibrio
fischeri) 		PF00275
(EPSP_synthase) 		5 LEU A 371
ALA A 375
ILE A 281
ILE A 234
LEU A 267
 None
 0.97A 5h8tA-3vcyA:
undetectable		 5h8tA-3vcyA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w7b FORMYLTETRAHYDROFOLA
TE DEFORMYLASE

(Thermus
thermophilus) 		PF00551
(Formyl_trans_N)
PF01842
(ACT) 		5 LEU A 160
LEU A 120
ALA A  92
ILE A 176
ILE A 156
 None
 1.12A 5h8tA-3w7bA:
undetectable		 5h8tA-3w7bA:
16.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wbg FATTY ACID-BINDING
PROTEIN, HEART

(Homo sapiens) 		PF00061
(Lipocalin) 		5 PHE A  16
TYR A  19
ALA A  33
SER A  55
LEU A 115
 2AN  A 201 ( 4.9A)
2AN  A 201 (-4.8A)
2AN  A 201 (-3.8A)
2AN  A 201 (-3.2A)
None
 0.63A 5h8tA-3wbgA:
20.5		 5h8tA-3wbgA:
35.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zh4 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Streptococcus
pneumoniae) 		PF00275
(EPSP_synthase) 		5 LEU A 371
ALA A 375
ILE A 282
ILE A 235
LEU A 268
 FLC  A1419 (-4.0A)
None
None
None
None
 1.10A 5h8tA-3zh4A:
undetectable		 5h8tA-3zh4A:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zxs CRYPTOCHROME B

(Rhodobacter
sphaeroides) 		PF04244
(DPRP) 		5 LEU A 113
ALA A 101
ILE A  51
ILE A  83
LEU A 395
 None
None
DLZ  A1511 (-4.0A)
None
DLZ  A1511 ( 4.4A)
 1.16A 5h8tA-3zxsA:
undetectable		 5h8tA-3zxsA:
13.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4a60 FATTY ACID-BINDING
PROTEIN 9 TESTIS
LIPID-BINDING
PROTEIN, TLBP,
TESTIS-TYPE FATTY
ACID-BINDING
PROTEIN, T-FABP

(Homo sapiens) 		PF00061
(Lipocalin) 		5 PHE A  17
TYR A  20
ALA A  34
ILE A  52
SER A  56
 None
None
NA  A1132 ( 4.0A)
None
NA  A1132 (-2.9A)
 0.62A 5h8tA-4a60A:
19.2		 5h8tA-4a60A:
30.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 834
ALA A 851
ARG A 863
ILE A 856
LEU A 886
 None
 1.03A 5h8tA-4agdA:
undetectable		 5h8tA-4agdA:
18.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4azp FATTY ACID-BINDING
PROTEIN, EPIDERMAL

(Mus musculus) 		PF00061
(Lipocalin) 		5 PHE A  19
TYR A  22
LEU A  32
ALA A  36
SER A  58
 None
None
A9M  A1136 ( 4.1A)
A9M  A1136 (-3.4A)
A9M  A1136 ( 4.1A)
 0.80A 5h8tA-4azpA:
20.7		 5h8tA-4azpA:
33.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bja PROTEIN GLB-12

(Caenorhabditis
elegans) 		PF00042
(Globin) 		5 PHE A 195
LEU A 119
ILE A  53
TYR A  97
LEU A 160
 None
 0.95A 5h8tA-4bjaA:
undetectable		 5h8tA-4bjaA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gk8 HISTIDINOL-PHOSPHATA
SE

(Lactococcus
lactis) 		PF02811
(PHP) 		5 ALA A 249
ILE A 169
TYR A 208
ILE A 194
LEU A 178
 None
 1.00A 5h8tA-4gk8A:
undetectable		 5h8tA-4gk8A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hb4 EXPORTIN-1

(Saccharomyces
cerevisiae) 		PF03810
(IBN_N)
PF08389
(Xpo1)
PF08767
(CRM1_C) 		5 LEU C 791
ALA C 794
ILE C 679
ILE C 766
LEU C 690
 None
 1.15A 5h8tA-4hb4C:
undetectable		 5h8tA-4hb4C:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		5 ALA A 384
ILE A 392
SER A 387
ILE A 331
LEU A 415
 None
 1.14A 5h8tA-4hq1A:
undetectable		 5h8tA-4hq1A:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ikn AP-3 COMPLEX SUBUNIT
MU-1

(Rattus
norvegicus) 		PF00928
(Adap_comp_sub) 		5 PHE A 222
LEU A 387
ILE A 210
ARG A 258
LEU A 392
 PHE  A 222 ( 1.3A)
LEU  A 387 ( 0.6A)
ILE  A 210 ( 0.7A)
ARG  A 258 ( 0.6A)
LEU  A 392 ( 0.5A)
 1.17A 5h8tA-4iknA:
undetectable		 5h8tA-4iknA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iwm UPF0135 PROTEIN
MJ0927

(Methanocaldococcus
jannaschii) 		PF01784
(NIF3) 		5 LEU A  67
LEU A 247
ALA A  48
ILE A  56
LEU A  74
 None
 1.18A 5h8tA-4iwmA:
undetectable		 5h8tA-4iwmA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0k TANNASE

(Lactobacillus
plantarum) 		no annotation 5 PHE A 265
TYR A 268
LEU A 269
ILE A 206
ILE A 429
 None
None
None
EGR  A 501 (-4.0A)
None
 1.10A 5h8tA-4j0kA:
undetectable		 5h8tA-4j0kA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jng NUCLEOCAPSID PROTEIN

(Sathuperi
orthobunyavirus) 		PF00952
(Bunya_nucleocap) 		5 PHE A  44
ALA A 145
ILE A  28
TYR A  99
LEU A  35
 None
 1.04A 5h8tA-4jngA:
undetectable		 5h8tA-4jngA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l4x AMPHI

(Streptomyces
nodosus) 		PF08659
(KR) 		5 LEU A 305
LEU A 325
ALA A 298
ARG A 295
LEU A 490
 None
 1.17A 5h8tA-4l4xA:
undetectable		 5h8tA-4l4xA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ni2 GUANYLATE CYCLASE
SOLUBLE SUBUNIT
BETA-1

(Homo sapiens) 		PF00211
(Guanylate_cyc) 		5 PHE B 457
TYR B 454
LEU B 453
ALA B 507
ILE B 427
 None
None
None
None
EDO  B 704 (-4.3A)
 0.95A 5h8tA-4ni2B:
undetectable		 5h8tA-4ni2B:
22.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nns FATTY ACID-BINDING
PROTEIN, ADIPOCYTE

(Homo sapiens) 		PF00061
(Lipocalin) 		5 PHE A  16
TYR A  19
ALA A  33
ILE A  51
SER A  55
 None
None
75D  A 201 ( 4.1A)
None
75D  A 201 ( 4.7A)
 0.79A 5h8tA-4nnsA:
20.1		 5h8tA-4nnsA:
31.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o89 RNA 3'-TERMINAL
PHOSPHATE CYCLASE

(Pyrococcus
horikoshii) 		PF01137
(RTC)
PF05189
(RTC_insert) 		5 LEU A 284
LEU A 245
ALA A 139
ILE A 322
ILE A 299
 None
 1.07A 5h8tA-4o89A:
undetectable		 5h8tA-4o89A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4okr MICRONEMAL PROTEIN
MIC2

(Toxoplasma
gondii) 		PF00090
(TSP_1)
PF00092
(VWA) 		5 PHE A  98
LEU A 245
ALA A 255
ILE A 108
ILE A 184
 None
 0.90A 5h8tA-4okrA:
undetectable		 5h8tA-4okrA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oku MICRONEMAL PROTEIN
MIC2

(Toxoplasma
gondii) 		PF00090
(TSP_1)
PF00092
(VWA) 		5 PHE A  98
LEU A 245
ALA A 255
ILE A 108
ILE A 184
 None
 0.90A 5h8tA-4okuA:
undetectable		 5h8tA-4okuA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozt ECDYSONE RECEPTOR
RETINOID X RECEPTOR

(Pediculus
humanus;
Pediculus
humanus) 		PF00104
(Hormone_recep)
PF00104
(Hormone_recep) 		5 PHE E 477
LEU E 481
ALA U 349
ILE E 292
ILE E 435
 None
 1.00A 5h8tA-4oztE:
undetectable		 5h8tA-4oztE:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7u UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Vibrio cholerae) 		PF00275
(EPSP_synthase) 		5 LEU A 371
ALA A 375
ILE A 281
ILE A 234
LEU A 267
 None
 1.04A 5h8tA-4r7uA:
undetectable		 5h8tA-4r7uA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rw3 PHOSPHOLIPASE D
LISICTOX-ALPHAIA1BII

(Loxosceles
intermedia) 		no annotation 5 LEU A  71
LEU A  86
ALA A 128
ILE A 134
LEU A 110
 None
 1.14A 5h8tA-4rw3A:
undetectable		 5h8tA-4rw3A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x3n CALCIUM-REGULATED
ACTIN-BUNDLING
PROTEIN

(Dictyostelium
discoideum) 		no annotation 5 PHE A 153
TYR A 156
LEU A 157
LEU A  50
ALA A  46
 None
 0.90A 5h8tA-4x3nA:
undetectable		 5h8tA-4x3nA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7r COENZYME PQQ
SYNTHESIS PROTEIN B

(Methylobacterium
extorquens) 		PF12706
(Lactamase_B_2) 		5 LEU A 190
LEU A 297
ALA A 212
ILE A 241
LEU A 203
 None
 1.11A 5h8tA-4z7rA:
undetectable		 5h8tA-4z7rA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zdk CTP SYNTHASE

(Mycobacterium
tuberculosis) 		PF00117
(GATase)
PF06418
(CTP_synth_N) 		5 PHE A 507
LEU A 455
ALA A 453
SER A 450
LEU A 392
 None
 1.16A 5h8tA-4zdkA:
undetectable		 5h8tA-4zdkA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7n MTA/SAH NUCLEOSIDASE

(Aeromonas
hydrophila) 		PF01048
(PNP_UDP_1) 		5 LEU A  66
LEU A  48
ALA A  47
ILE A 117
ILE A  33
 None
 1.08A 5h8tA-5b7nA:
undetectable		 5h8tA-5b7nA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bu2 LPG1496

(Legionella
pneumophila) 		PF12252
(SidE) 		5 LEU A 300
ALA A 375
SER A 412
ILE A 309
LEU A 467
 None
None
ADP  A 702 (-4.9A)
None
None
 1.14A 5h8tA-5bu2A:
undetectable		 5h8tA-5bu2A:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csc CITRATE SYNTHASE

(Gallus gallus) 		PF00285
(Citrate_synt) 		5 LEU B 403
ALA B 402
ILE B 200
MET B 216
LEU B 120
 None
 1.01A 5h8tA-5cscB:
undetectable		 5h8tA-5cscB:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dv5 GNTR FAMILY
TRANSCRIPTIONAL
REGULATOR

(Vibrio
alginolyticus) 		PF00392
(GntR)
PF07840
(FadR_C) 		5 ALA A   9
ILE A  20
TYR A  15
ILE A  41
LEU A  61
 None
 1.03A 5h8tA-5dv5A:
undetectable		 5h8tA-5dv5A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9a BETA-GALACTOSIDASE

(Rahnella sp. R3) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		5 LEU A  73
LEU A  76
ALA A 148
ILE A 154
LEU A 241
 None
 1.08A 5h8tA-5e9aA:
undetectable		 5h8tA-5e9aA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hp6 EXTRACELLULAR
ARABINANASE

(Geobacillus
stearothermophilus) 		PF04616
(Glyco_hydro_43)
PF13385
(Laminin_G_3)
PF16369
(GH43_C) 		5 LEU A 835
ALA A 776
ILE A 698
ARG A 829
ILE A 830
 None
 1.12A 5h8tA-5hp6A:
undetectable		 5h8tA-5hp6A:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jm7 AEROBACTIN SYNTHASE
IUCA

(Klebsiella
pneumoniae) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		5 LEU A 507
LEU A 501
ALA A 396
ILE A 429
LEU A 408
 None
 1.01A 5h8tA-5jm7A:
undetectable		 5h8tA-5jm7A:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbw RIBOFLAVIN
TRANSPORTER RIBU

(Thermotoga
maritima) 		PF12822
(ECF_trnsprt) 		5 PHE A  33
LEU A  34
ALA A  31
TYR A 138
ILE A 145
 RBF  A 201 (-4.4A)
RBF  A 201 (-4.9A)
None
None
RBF  A 201 ( 4.6A)
 1.08A 5h8tA-5kbwA:
undetectable		 5h8tA-5kbwA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lki TCDA1

(Photorhabdus
luminescens) 		PF03538
(VRP1) 		5 TYR A2341
LEU A2353
ILE A2511
ILE A2507
LEU A2396
 None
 1.12A 5h8tA-5lkiA:
2.0		 5h8tA-5lkiA:
4.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqs BETA-L-ARABINOBIOSID
ASE

(Bacteroides
thetaiotaomicron) 		PF13088
(BNR_2) 		5 LEU A 317
LEU A 339
ALA A 323
ILE A 404
LEU A  81
 None
 1.01A 5h8tA-5mqsA:
undetectable		 5h8tA-5mqsA:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5noi ROUNDABOUT HOMOLOG 2

(Homo sapiens) 		no annotation 5 TYR A 486
LEU A 437
LEU A 436
ILE A 480
ILE A 475
 None
 1.13A 5h8tA-5noiA:
undetectable		 5h8tA-5noiA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o5l ADENYLATE CYCLASE

(Mycobacterium
intracellulare) 		no annotation 5 PHE A 283
TYR A 280
LEU A 279
ALA A 330
ILE A 257
 None
 0.93A 5h8tA-5o5lA:
undetectable		 5h8tA-5o5lA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u25 DIHYDROLIPOAMIDE
DEHYDROGENASE (E3
COMPONENT OF
PYRUVATE AND
2-OXOGLUTARATE
DEHYDROGENASE
COMPLEXES)

(Neisseria
gonorrhoeae) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 PHE A 523
LEU A 582
ALA A 581
ILE A 544
ILE A 560
 None
 1.14A 5h8tA-5u25A:
undetectable		 5h8tA-5u25A:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w81 CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR

(Danio rerio) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane)
PF14396
(CFTR_R) 		5 LEU A1121
LEU A1030
ALA A1026
ILE A1139
SER A1017
 None
 1.17A 5h8tA-5w81A:
undetectable		 5h8tA-5w81A:
6.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6j NUCLEOPROTEIN

(Tomato spotted
wilt
orthotospovirus) 		PF01533
(Tospo_nucleocap) 		5 LEU A 150
ALA A 167
TYR A 215
ILE A 162
LEU A 132
 None
 1.09A 5h8tA-5y6jA:
undetectable		 5h8tA-5y6jA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvt C-TERMINUS OF OUTER
CAPSID PROTEIN VP5

(Aquareovirus C) 		no annotation 5 LEU B 366
ALA B 404
ILE B 394
ILE B 445
LEU B 440
 None
 1.17A 5h8tA-5zvtB:
undetectable		 5h8tA-5zvtB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c62 BIURET HYDROLASE

(Pseudomonas sp.
ADP) 		no annotation 5 TYR A  71
LEU A 115
LEU A  25
ALA A  24
ARG A  18
 None
 1.13A 5h8tA-6c62A:
undetectable		 5h8tA-6c62A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d0g PIRIN FAMILY PROTEIN

(Acinetobacter
baumannii) 		no annotation 5 LEU A  57
ALA A 134
ILE A 243
ILE A 254
LEU A 226
 None
 1.13A 5h8tA-6d0gA:
undetectable		 5h8tA-6d0gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gi2 FERRIC ENTEROBACTIN
ESTERASE

(Pseudomonas
aeruginosa) 		no annotation 5 PHE A 174
LEU A 153
LEU A 162
ILE A  86
LEU A 146
 None
 1.05A 5h8tA-6gi2A:
undetectable		 5h8tA-6gi2A:
undetectable