SIMILAR PATTERNS OF AMINO ACIDS FOR 5H5F_A_SAMA301_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jpd L-ALA-D/L-GLU
EPIMERASE

(Escherichia
coli) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLY X 317
PRO X 301
THR X 121
THR X 315
 None
 1.22A 5h5fA-1jpdX:
1.8		 5h5fA-1jpdX:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kb0 QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE

(Comamonas
testosteroni) 		PF13360
(PQQ_2)
PF13442
(Cytochrome_CBB3) 		4 GLY A 498
PRO A 478
THR A 495
THR A 552
 None
None
GOL  A1820 ( 4.7A)
GOL  A1823 (-4.3A)
 1.22A 5h5fA-1kb0A:
undetectable		 5h5fA-1kb0A:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mio NITROGENASE
MOLYBDENUM IRON
PROTEIN (BETA CHAIN)

(Clostridium
pasteurianum) 		PF00148
(Oxidored_nitro) 		4 GLY B  44
PRO B  40
THR B  68
THR B 105
 None
None
None
CLP  B 498 (-4.0A)
 1.07A 5h5fA-1mioB:
1.2		 5h5fA-1mioB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1npe NIDOGEN

(Mus musculus) 		PF00058
(Ldl_recept_b) 		4 GLY A 995
PRO A 970
THR A 965
THR A1008
 None
 1.23A 5h5fA-1npeA:
undetectable		 5h5fA-1npeA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oh2 SUCROSE SPECIFIC
PORIN

(Salmonella
enterica) 		PF02264
(LamB) 		4 GLY Q 106
PRO Q 404
THR Q 104
THR Q  99
 None
 1.28A 5h5fA-1oh2Q:
undetectable		 5h5fA-1oh2Q:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ovw ENDOGLUCANASE I

(Fusarium
oxysporum) 		PF00840
(Glyco_hydro_7) 		4 GLY A 392
THR A 397
GLN A 271
THR A 125
 None
 0.87A 5h5fA-1ovwA:
undetectable		 5h5fA-1ovwA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pjq SIROHEME SYNTHASE

(Salmonella
enterica) 		PF00590
(TP_methylase)
PF10414
(CysG_dimeriser)
PF13241
(NAD_binding_7)
PF14824
(Sirohm_synth_M) 		4 GLY A 335
PRO A 436
THR A 412
THR A 331
 None
None
None
ACT  A 505 (-3.4A)
 1.02A 5h5fA-1pjqA:
2.5		 5h5fA-1pjqA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q14 HST2 PROTEIN

(Saccharomyces
cerevisiae) 		PF02146
(SIR2) 		4 GLY A  32
PRO A 235
THR A 224
THR A 114
 None
 1.28A 5h5fA-1q14A:
0.8		 5h5fA-1q14A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q33 ADP-RIBOSE
PYROPHOSPHATASE

(Homo sapiens) 		PF00293
(NUDIX) 		4 GLY A 158
PRO A  71
THR A 275
THR A 100
 None
 1.27A 5h5fA-1q33A:
undetectable		 5h5fA-1q33A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q44 STEROID
SULFOTRANSFERASE

(Arabidopsis
thaliana) 		PF00685
(Sulfotransfer_1) 		4 GLY A  12
PRO A   8
THR A  17
GLN A  48
 None
 1.25A 5h5fA-1q44A:
undetectable		 5h5fA-1q44A:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tt4 PUTATIVE CYTOPLASMIC
PROTEIN

(Salmonella
enterica) 		PF04107
(GCS2) 		4 GLY A  15
THR A  13
GLN A  71
THR A  63
 None
 1.26A 5h5fA-1tt4A:
undetectable		 5h5fA-1tt4A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6g TIP120 PROTEIN

(Homo sapiens) 		PF08623
(TIP120) 		4 PRO C 377
THR C 405
GLN C 431
THR C 426
 None
 1.27A 5h5fA-1u6gC:
undetectable		 5h5fA-1u6gC:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ux6 THROMBOSPONDIN-1

(Homo sapiens) 		PF02412
(TSP_3)
PF05735
(TSP_C) 		4 GLY A1070
PRO A1034
THR A1068
THR A1051
 None
 1.10A 5h5fA-1ux6A:
undetectable		 5h5fA-1ux6A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5f PYRUVATE OXIDASE

(Aerococcus
viridans) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 GLY A 215
PRO A 404
THR A 218
THR A 239
 FAD  A1601 (-2.9A)
None
None
FAD  A1601 (-2.8A)
 1.07A 5h5fA-1v5fA:
undetectable		 5h5fA-1v5fA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5w MEIOTIC
RECOMBINATION
PROTEIN DMC1/LIM15
HOMOLOG

(Homo sapiens) 		PF08423
(Rad51) 		4 GLY A 333
THR A 138
GLN A 134
THR A 331
 None
 1.30A 5h5fA-1v5wA:
undetectable		 5h5fA-1v5wA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wiw GLUCOSE-6-PHOSPHATE
ISOMERASE LIKE
PROTEIN

(Thermus
thermophilus) 		PF10432
(bact-PGI_C) 		4 GLY A 177
PRO A 165
THR A 193
THR A 181
 None
 1.26A 5h5fA-1wiwA:
undetectable		 5h5fA-1wiwA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ydw AX110P-LIKE PROTEIN

(Arabidopsis
thaliana) 		PF01408
(GFO_IDH_MocA) 		4 PRO A 268
THR A 137
GLN A 306
THR A 129
 None
 1.27A 5h5fA-1ydwA:
2.5		 5h5fA-1ydwA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae) 		PF01263
(Aldose_epim)
PF16363
(GDP_Man_Dehyd) 		4 GLY A 667
THR A 535
GLN A 645
THR A 643
 None
None
GAL  A 700 (-4.0A)
None
 1.20A 5h5fA-1z45A:
3.1		 5h5fA-1z45A:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2afh NITROGENASE
MOLYBDENUM-IRON
PROTEIN

(Azotobacter
vinelandii) 		PF00148
(Oxidored_nitro)
PF11844
(DUF3364) 		4 GLY B  81
PRO B 180
GLN B 278
THR B 276
 None
 1.17A 5h5fA-2afhB:
undetectable		 5h5fA-2afhB:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csd TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13412
(HTH_24)
PF14520
(HHH_5) 		4 GLY A 420
PRO A 434
THR A 414
THR A 423
 None
 1.04A 5h5fA-2csdA:
undetectable		 5h5fA-2csdA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2exr CYTOKININ
DEHYDROGENASE 7

(Arabidopsis
thaliana) 		PF01565
(FAD_binding_4)
PF09265
(Cytokin-bind) 		4 GLY A 176
PRO A 157
THR A 161
THR A 188
 FAD  A 525 (-3.5A)
None
FAD  A 525 (-4.1A)
None
 1.00A 5h5fA-2exrA:
undetectable		 5h5fA-2exrA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iv2 FORMATE
DEHYDROGENASE H

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 GLY X 345
PRO X 510
GLN X 355
THR X 350
 None
 1.30A 5h5fA-2iv2X:
undetectable		 5h5fA-2iv2X:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mvo PUTATIVE LIPOPROTEIN

(Microbispora
sp. ATCC
PTA-5024) 		PF10709
(DUF2511) 		4 PRO A  53
THR A  79
GLN A  60
THR A 134
 None
 1.30A 5h5fA-2mvoA:
undetectable		 5h5fA-2mvoA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oq2 PHOSPHOADENOSINE
PHOSPHOSULFATE
REDUCTASE

(Saccharomyces
cerevisiae) 		PF01507
(PAPS_reduct) 		4 GLY A  54
PRO A  71
THR A  57
THR A  48
 A3P  A 999 (-3.1A)
None
None
A3P  A 999 (-3.6A)
 1.01A 5h5fA-2oq2A:
2.0		 5h5fA-2oq2A:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF06471
(NSP11) 		4 GLY A 169
PRO A 157
THR A 174
GLN A 159
 None
 1.07A 5h5fA-2ozkA:
undetectable		 5h5fA-2ozkA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhp THROMBOSPONDIN-2

(Homo sapiens) 		PF02412
(TSP_3)
PF05735
(TSP_C)
PF07645
(EGF_CA)
PF12947
(EGF_3) 		4 GLY A1090
PRO A1054
THR A1088
THR A1071
 None
None
None
NAG  A   4 (-4.4A)
 1.16A 5h5fA-2rhpA:
undetectable		 5h5fA-2rhpA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v1w PDZ AND LIM DOMAIN
PROTEIN 4

(Homo sapiens) 		PF00595
(PDZ) 		4 GLY A  46
PRO A   2
GLN A  50
THR A  28
 None
 1.12A 5h5fA-2v1wA:
undetectable		 5h5fA-2v1wA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2we9 MOBA-RELATED PROTEIN

(Mycobacterium
tuberculosis) 		PF12804
(NTP_transf_3) 		4 GLY A  35
PRO A  22
THR A  32
GLN A  24
 None
 1.26A 5h5fA-2we9A:
2.8		 5h5fA-2we9A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yok EXOGLUCANASE 1

(Trichoderma
harzianum) 		PF00840
(Glyco_hydro_7) 		4 GLY A 437
PRO A  43
GLN A  34
THR A 442
 None
 1.27A 5h5fA-2yokA:
undetectable		 5h5fA-2yokA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aeu LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT N

(Rhodobacter
capsulatus) 		PF00148
(Oxidored_nitro) 		4 GLY A 153
PRO A 224
GLN A 304
THR A 148
 None
 1.13A 5h5fA-3aeuA:
undetectable		 5h5fA-3aeuA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bgk PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
mutans) 		PF01256
(Carb_kinase) 		4 GLY A 214
THR A 218
GLN A 210
THR A 212
 PO4  A 278 (-3.3A)
None
None
None
 1.16A 5h5fA-3bgkA:
3.1		 5h5fA-3bgkA:
25.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bm1 PROTEIN YDJA

(Escherichia
coli) 		PF00881
(Nitroreductase) 		4 GLY A 156
PRO A  83
THR A  91
THR A 137
 None
 1.18A 5h5fA-3bm1A:
undetectable		 5h5fA-3bm1A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cnj CHOLESTEROL OXIDASE

(Streptomyces
sp. SA-COO) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 GLY A 315
PRO A 448
THR A 295
THR A 387
 None
 1.14A 5h5fA-3cnjA:
1.9		 5h5fA-3cnjA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwo PROBABLE OUTER
MEMBRANE PROTEIN

(Pseudomonas
aeruginosa) 		PF03349
(Toluene_X) 		4 PRO X  98
THR X   7
GLN X 116
THR X 147
 None
 1.02A 5h5fA-3dwoX:
undetectable		 5h5fA-3dwoX:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eag UDP-N-ACETYLMURAMATE
:L-ALANYL-GAMMA-D-GL
UTAMYL-MESO-DIAMINOP
IMELATE LIGASE

(Neisseria
meningitidis) 		PF01225
(Mur_ligase)
PF08245
(Mur_ligase_M) 		4 GLY A  16
PRO A  38
THR A  12
GLN A  42
 None
 1.30A 5h5fA-3eagA:
4.4		 5h5fA-3eagA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hfq UNCHARACTERIZED
PROTEIN LP_2219

(Lactobacillus
plantarum) 		PF10282
(Lactonase) 		4 GLY A  17
PRO A  87
THR A  39
THR A   9
 None
 1.26A 5h5fA-3hfqA:
undetectable		 5h5fA-3hfqA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3it7 PROTEASE LASA

(Pseudomonas
aeruginosa) 		PF01551
(Peptidase_M23) 		4 GLY A 104
THR A  48
GLN A  84
THR A 108
 None
 1.04A 5h5fA-3it7A:
undetectable		 5h5fA-3it7A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iz3 STRUCTURAL PROTEIN
VP1

(Cypovirus 1) 		no annotation 4 GLY B 200
PRO B1213
GLN B 173
THR B 175
 None
 1.26A 5h5fA-3iz3B:
undetectable		 5h5fA-3iz3B:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kq4 GASTRIC INTRINSIC
FACTOR

(Homo sapiens) 		PF01122
(Cobalamin_bind)
PF14478
(DUF4430) 		4 GLY A 391
THR A 393
GLN A 387
THR A 411
 None
None
NAG  A2002 ( 4.8A)
None
 1.03A 5h5fA-3kq4A:
undetectable		 5h5fA-3kq4A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kyh MRNA-CAPPING ENZYME
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF01331
(mRNA_cap_enzyme)
PF03919
(mRNA_cap_C) 		4 GLY C  73
PRO C 221
THR C  71
GLN C 136
 None
 1.06A 5h5fA-3kyhC:
undetectable		 5h5fA-3kyhC:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6v DNA GYRASE SUBUNIT A

(Xanthomonas
campestris) 		PF03989
(DNA_gyraseA_C) 		4 GLY A 785
THR A 782
GLN A 854
THR A 857
 None
 1.24A 5h5fA-3l6vA:
undetectable		 5h5fA-3l6vA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA
SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA

(Archaeoglobus
fulgidus;
Archaeoglobus
fulgidus) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr)
PF00037
(Fer4)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 GLY A 125
PRO B  59
THR A 127
THR A  24
 None
 1.28A 5h5fA-3mm5A:
undetectable		 5h5fA-3mm5A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mqt MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Shewanella
pealeana) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLY A  36
PRO A  75
THR A  32
GLN A 116
 None
 1.16A 5h5fA-3mqtA:
undetectable		 5h5fA-3mqtA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3npe 9-CIS-EPOXYCAROTENOI
D DIOXYGENASE 1,
CHLOROPLASTIC

(Zea mays) 		PF03055
(RPE65) 		4 PRO A 469
THR A 514
GLN A 472
THR A 518
 None
 1.28A 5h5fA-3npeA:
undetectable		 5h5fA-3npeA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ojl CAP5O

(Staphylococcus
aureus) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		4 GLY A 141
PRO A 131
THR A 139
THR A 173
 None
 1.20A 5h5fA-3ojlA:
undetectable		 5h5fA-3ojlA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdi NITROGENASE MOFE
COFACTOR
BIOSYNTHESIS PROTEIN
NIFN

(Azotobacter
vinelandii) 		PF00148
(Oxidored_nitro) 		4 GLY B  40
PRO B  36
THR B  64
THR B 101
 None
 1.01A 5h5fA-3pdiB:
undetectable		 5h5fA-3pdiB:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3poy NEUREXIN-1-ALPHA

(Bos taurus) 		PF00008
(EGF)
PF02210
(Laminin_G_2) 		4 GLY A 690
PRO A 642
THR A 688
THR A 509
 None
 1.23A 5h5fA-3poyA:
undetectable		 5h5fA-3poyA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q98 TRANSCARBAMYLASE

(Escherichia
coli) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 GLY A 213
PRO A  32
THR A  27
THR A 216
 None
 1.21A 5h5fA-3q98A:
undetectable		 5h5fA-3q98A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qcw NEUREXIN-1-ALPHA

(Bos taurus) 		PF00008
(EGF)
PF02210
(Laminin_G_2) 		4 GLY A 674
PRO A 626
THR A 672
THR A 493
 None
 1.25A 5h5fA-3qcwA:
undetectable		 5h5fA-3qcwA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qml 78 KDA
GLUCOSE-REGULATED
PROTEIN HOMOLOG

(Saccharomyces
cerevisiae) 		PF00012
(HSP70) 		4 GLY A 247
PRO A 193
THR A 249
THR A  60
 PO4  A   2 (-3.3A)
None
PO4  A   2 ( 4.7A)
PO4  A   2 (-3.0A)
 1.22A 5h5fA-3qmlA:
undetectable		 5h5fA-3qmlA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s46 ALANINE RACEMASE

(Streptococcus
pneumoniae) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 GLY A 262
PRO A 303
THR A 314
THR A 266
 None
 1.14A 5h5fA-3s46A:
undetectable		 5h5fA-3s46A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t63 PROTOCATECHUATE
3,4-DIOXYGENASE BETA
CHAIN

(Pseudomonas
putida) 		PF00775
(Dioxygenase_C)
PF12391
(PCDO_beta_N) 		4 PRO M 468
THR M 346
GLN M 530
THR M 533
 None
 1.23A 5h5fA-3t63M:
undetectable		 5h5fA-3t63M:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN

(Escherichia
coli) 		PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF) 		4 GLY A 135
PRO A 302
THR A 108
GLN A 307
 None
 1.12A 5h5fA-3ttfA:
undetectable		 5h5fA-3ttfA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uk6 RUVB-LIKE 2

(Homo sapiens) 		PF06068
(TIP49) 		4 GLY A 394
PRO A 361
THR A 367
THR A 397
 None
 1.27A 5h5fA-3uk6A:
undetectable		 5h5fA-3uk6A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3whs GAMMA-GLUTAMYLTRANSP
EPTIDASE SMALL CHAIN

(Bacillus
subtilis) 		PF01019
(G_glu_transpept) 		4 GLY B 485
PRO B 468
THR B 403
THR B 488
 AVN  B 600 (-4.5A)
None
AVN  B 600 (-1.9A)
None
 1.26A 5h5fA-3whsB:
undetectable		 5h5fA-3whsB:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zg8 PENICILLIN-BINDING
PROTEIN 4

(Listeria
monocytogenes) 		PF00905
(Transpeptidase)
PF00912
(Transgly) 		4 GLY B 393
PRO B 497
THR B 395
THR B 579
 AIX  B 800 (-3.9A)
None
None
GOL  B1643 (-4.3A)
 1.29A 5h5fA-3zg8B:
undetectable		 5h5fA-3zg8B:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zif PVIII

(Bovine
mastadenovirus
B) 		PF01310
(Adeno_PVIII) 		4 GLY R  22
PRO R  15
THR R  12
GLN R  14
 None
 1.14A 5h5fA-3zifR:
undetectable		 5h5fA-3zifR:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvc ALCOHOL
DEHYDROGENASE

(Pseudogluconobacter
saccharoketogenes) 		PF13360
(PQQ_2) 		4 GLY A 252
PRO A 328
THR A 255
GLN A 325
 None
 1.20A 5h5fA-4cvcA:
undetectable		 5h5fA-4cvcA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ehj PHOSPHOGLYCERATE
KINASE

(Francisella
tularensis) 		PF00162
(PGK) 		4 GLY A 316
PRO A 293
GLN A 296
THR A 327
 None
 1.29A 5h5fA-4ehjA:
2.7		 5h5fA-4ehjA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4esj TYPE-2 RESTRICTION
ENZYME DPNI

(Streptococcus
pneumoniae) 		PF06044
(DpnI) 		4 GLY A 187
PRO A 114
THR A 119
THR A 189
 None
 1.23A 5h5fA-4esjA:
undetectable		 5h5fA-4esjA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hhr ALPHA-DIOXYGENASE

(Arabidopsis
thaliana) 		PF03098
(An_peroxidase) 		4 GLY A 226
PRO A 468
THR A 231
THR A 216
 None
None
CL  A 713 ( 4.5A)
CA  A 703 (-3.6A)
 1.20A 5h5fA-4hhrA:
undetectable		 5h5fA-4hhrA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iss ALLOPHANATE
HYDROLASE

(Kluyveromyces
lactis) 		PF01425
(Amidase) 		4 GLY A 176
PRO A 379
THR A 402
GLN A 398
 TAR  A 701 (-3.7A)
None
None
None
 0.98A 5h5fA-4issA:
undetectable		 5h5fA-4issA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kc5 RHIE PROTEIN

(Paraburkholderia
rhizoxinica) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 GLY A3547
PRO A3629
THR A3543
THR A3164
 None
 1.22A 5h5fA-4kc5A:
undetectable		 5h5fA-4kc5A:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lhu 9C2 TCR GAMMA CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLY G 152
THR G 200
GLN G 149
THR G 146
 None
 1.20A 5h5fA-4lhuG:
undetectable		 5h5fA-4lhuG:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n03 ABC-TYPE
BRANCHED-CHAIN AMINO
ACID TRANSPORT
SYSTEMS PERIPLASMIC
COMPONENT-LIKE
PROTEIN

(Thermomonospora
curvata) 		PF13458
(Peripla_BP_6) 		4 GLY A  68
PRO A 122
THR A  58
GLN A  75
 None
 0.63A 5h5fA-4n03A:
undetectable		 5h5fA-4n03A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nes UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Methanocaldococcus
jannaschii) 		PF02350
(Epimerase_2) 		4 GLY A   8
THR A  35
GLN A  70
THR A  96
 None
None
UD1  A 400 ( 4.0A)
UD1  A 400 (-4.1A)
 1.14A 5h5fA-4nesA:
undetectable		 5h5fA-4nesA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otu GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Bacillus
licheniformis) 		PF01019
(G_glu_transpept) 		4 GLY B 481
PRO B 464
THR B 399
THR B 484
 GLU  B 602 ( 4.2A)
None
GLU  B 602 (-2.7A)
None
 1.07A 5h5fA-4otuB:
undetectable		 5h5fA-4otuB:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q16 NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Deinococcus
radiodurans) 		PF02540
(NAD_synthase) 		4 GLY A  57
PRO A 208
THR A  61
GLN A 101
 SO4  A 301 (-3.3A)
None
None
None
 1.05A 5h5fA-4q16A:
undetectable		 5h5fA-4q16A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6t GLYCOSYL HYDROLASE,
FAMILY 18

(Pseudomonas
protegens) 		PF00704
(Glyco_hydro_18) 		4 GLY A  40
THR A  64
GLN A  83
THR A  81
 None
 1.16A 5h5fA-4q6tA:
undetectable		 5h5fA-4q6tA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rv2 UPF0336 PROTEIN
MSMEG_1340/MSMEI_130
2
MAOC FAMILY PROTEIN

(Mycolicibacterium
smegmatis;
Mycolicibacterium
smegmatis) 		PF13452
(MaoC_dehydrat_N)
PF01575
(MaoC_dehydratas) 		4 GLY B  67
PRO A  54
THR B  71
THR A  58
 None
 1.19A 5h5fA-4rv2B:
undetectable		 5h5fA-4rv2B:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xvg ALKYL HYDROPEROXIDE
REDUCTASE SUBUNIT F

(Escherichia
coli) 		PF07992
(Pyr_redox_2)
PF13192
(Thioredoxin_3) 		4 GLY A  99
PRO A  70
THR A  97
THR A  18
 None
 1.23A 5h5fA-4xvgA:
undetectable		 5h5fA-4xvgA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ygt UNCHARACTERIZED
PROTEIN YJGB

(Bacillus
subtilis) 		PF14172
(DUF4309) 		4 GLY A  61
THR A  57
GLN A  68
THR A  71
 None
 1.26A 5h5fA-4ygtA:
undetectable		 5h5fA-4ygtA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yr1 ALKALINE PHOSPHATASE

(Escherichia
coli) 		PF00245
(Alk_phosphatase) 		4 GLY A 170
THR A 174
GLN A 194
THR A 192
 None
 1.29A 5h5fA-4yr1A:
undetectable		 5h5fA-4yr1A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7m BETA-XYLOSIDASE

(Trichoderma
reesei) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 GLY A 172
PRO A 239
GLN A 240
THR A 170
 None
 1.21A 5h5fA-5a7mA:
undetectable		 5h5fA-5a7mA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aex AMMONIUM TRANSPORTER
MEP2

(Saccharomyces
cerevisiae) 		PF00909
(Ammonium_transp) 		4 GLY A  16
PRO A 121
THR A  14
THR A  21
 None
 1.06A 5h5fA-5aexA:
undetectable		 5h5fA-5aexA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyx PROTEIN CDHR2

(Mus musculus) 		PF00028
(Cadherin) 		4 GLY A 191
THR A 199
GLN A 140
THR A 135
 None
 1.25A 5h5fA-5cyxA:
undetectable		 5h5fA-5cyxA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A

(Homo sapiens) 		PF00149
(Metallophos) 		4 GLY A 292
PRO A 333
THR A  44
THR A 294
 None
 1.13A 5h5fA-5ebbA:
undetectable		 5h5fA-5ebbA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A

(Mus musculus) 		PF00149
(Metallophos) 		4 GLY A 289
PRO A 330
THR A  41
THR A 291
 None
 1.18A 5h5fA-5fcaA:
undetectable		 5h5fA-5fcaA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g4l OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN

(Clostridium sp.) 		PF13561
(adh_short_C2) 		4 GLY A  24
PRO A 232
THR A 101
THR A  26
 NDP  A1265 ( 4.1A)
None
None
NDP  A1265 (-2.8A)
 1.19A 5h5fA-5g4lA:
undetectable		 5h5fA-5g4lA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gv1 ENDO-1,4-BETA-XYLANA
SE

(termite gut
metagenome) 		PF00457
(Glyco_hydro_11) 		4 GLY A 178
PRO A 160
GLN A 208
THR A 175
 None
 1.29A 5h5fA-5gv1A:
undetectable		 5h5fA-5gv1A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gyg ENDO-1,4-BETA-XYLANA
SE

(termite gut
metagenome) 		PF00457
(Glyco_hydro_11) 		4 GLY A 178
PRO A 160
GLN A 208
THR A 175
 None
 1.26A 5h5fA-5gygA:
undetectable		 5h5fA-5gygA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hqb ALPHA-GLUCOSIDASE

(Pseudoalteromonas
sp. K8) 		PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C) 		4 GLY A 671
PRO A 490
THR A 530
THR A 610
 None
 1.12A 5h5fA-5hqbA:
undetectable		 5h5fA-5hqbA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hva DR2231

(Deinococcus
radiodurans) 		PF01503
(PRA-PH) 		4 GLY A  95
PRO A  33
THR A  30
THR A  25
 None
 1.24A 5h5fA-5hvaA:
undetectable		 5h5fA-5hvaA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8i UREA AMIDOLYASE

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF01425
(Amidase)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 GLY A 176
PRO A 379
THR A 402
GLN A 398
 None
 0.96A 5h5fA-5i8iA:
2.3		 5h5fA-5i8iA:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9w ACETOPHENONE
CARBOXYLASE ALPHA
SUBUNIT

(Aromatoleum
aromaticum) 		PF01968
(Hydantoinase_A)
PF05378
(Hydant_A_N) 		4 GLY b  10
PRO b 341
THR b 278
THR b  30
 None
 1.18A 5h5fA-5l9wb:
undetectable		 5h5fA-5l9wb:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9w ACETOPHENONE
CARBOXYLASE ALPHA
SUBUNIT

(Aromatoleum
aromaticum) 		PF01968
(Hydantoinase_A)
PF05378
(Hydant_A_N) 		4 GLY b 277
PRO b 251
THR b 279
THR b  11
 ADP  b 801 (-3.3A)
None
None
ADP  b 801 (-2.9A)
 1.14A 5h5fA-5l9wb:
undetectable		 5h5fA-5l9wb:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mz9 -

(-) 		no annotation 4 GLY A 654
PRO A 506
THR A 652
GLN A 540
 None
 1.14A 5h5fA-5mz9A:
undetectable		 5h5fA-5mz9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzs FERRIC ENTEROBACTIN
RECEPTOR

(Pseudomonas
aeruginosa) 		no annotation 4 GLY A  80
THR A  84
GLN A  73
THR A  60
 None
 1.29A 5h5fA-5mzsA:
undetectable		 5h5fA-5mzsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd1 CAPSID PROTEIN
CAPSID PROTEIN

(Rosellinia
necatrix
quadrivirus 1;
Rosellinia
necatrix
quadrivirus 1) 		no annotation
no annotation 		4 GLY B 646
PRO A 924
THR B 629
THR B 596
 None
 1.23A 5h5fA-5nd1B:
undetectable		 5h5fA-5nd1B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ndl CRH-LIKE PROTEIN

(Aspergillus
fumigatus) 		no annotation 4 GLY A 223
PRO A 156
GLN A 157
THR A 104
 None
 1.21A 5h5fA-5ndlA:
undetectable		 5h5fA-5ndlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oc9 -

(-) 		no annotation 4 GLY A 202
PRO A 172
GLN A 125
THR A 120
 None
 1.16A 5h5fA-5oc9A:
undetectable		 5h5fA-5oc9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus) 		PF02538
(Hydantoinase_B) 		4 GLY A 431
PRO A 481
THR A 463
GLN A 362
 None
 1.18A 5h5fA-5svcA:
undetectable		 5h5fA-5svcA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t77 PUTATIVE LIPID II
FLIPPASE MURJ

(Thermosipho
africanus) 		PF03023
(MVIN) 		4 GLY A 345
PRO A 413
THR A 349
THR A 298
 None
1PE  A 512 ( 4.3A)
None
None
 1.10A 5h5fA-5t77A:
undetectable		 5h5fA-5t77A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wa2 SURFACE ANTIGEN

(Toxoplasma
gondii) 		no annotation 4 GLY A 143
PRO A 175
GLN A 240
THR A 138
 None
 1.17A 5h5fA-5wa2A:
undetectable		 5h5fA-5wa2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xil PUTATIVE PROLYL-TRNA
SYNTHETASE

(Leishmania
major) 		no annotation 4 GLY A 688
PRO A 724
GLN A 727
THR A 747
 None
 1.28A 5h5fA-5xilA:
undetectable		 5h5fA-5xilA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08163
(NUC194) 		4 GLY C1226
PRO C1158
THR C1223
GLN C1231
 None
 1.26A 5h5fA-5y3rC:
undetectable		 5h5fA-5y3rC:
4.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y4f ANKYRIN-2

(Homo sapiens) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13637
(Ank_4)
PF13857
(Ank_5) 		4 PRO A 835
THR A 729
GLN A 766
THR A 762
 None
 1.18A 5h5fA-5y4fA:
undetectable		 5h5fA-5y4fA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y4k DMSP LYASE DDDY

(Acinetobacter
bereziniae) 		no annotation 4 GLY A 354
THR A 275
GLN A 322
THR A 342
 None
 0.91A 5h5fA-5y4kA:
undetectable		 5h5fA-5y4kA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6azp MYELOPEROXIDASE

(Homo sapiens) 		no annotation 4 GLY A 615
PRO A 609
THR A 619
THR A 613
 None
 1.27A 5h5fA-6azpA:
undetectable		 5h5fA-6azpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dgi D-ALANINE--D-ALANINE
LIGASE

(Vibrio cholerae) 		no annotation 4 GLY A  84
PRO A 108
THR A  89
GLN A  93
 ACT  A 402 ( 4.1A)
GOL  A 401 (-4.6A)
None
None
 1.24A 5h5fA-6dgiA:
undetectable		 5h5fA-6dgiA:
undetectable