SIMILAR PATTERNS OF AMINO ACIDS FOR 5H5F_A_SAMA301_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a33 PEPTIDYLPROLYL
ISOMERASE

(Brugia malayi) 		PF00160
(Pro_isomerase) 		5 PHE A  64
ILE A  15
GLY A  17
ARG A  22
LEU A  11
 None
 1.12A 5h5fA-1a33A:
undetectable		 5h5fA-1a33A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a3x PYRUVATE KINASE

(Saccharomyces
cerevisiae) 		PF00224
(PK)
PF02887
(PK_C) 		5 ILE A 420
GLY A 438
ARG A 415
LEU A 473
ALA A 467
 None
 1.11A 5h5fA-1a3xA:
undetectable		 5h5fA-1a3xA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hz4 MALT REGULATORY
PROTEIN

(Escherichia
coli) 		no annotation 5 GLY A 186
ASP A 187
ARG A 363
LEU A 362
ALA A 338
 None
 1.08A 5h5fA-1hz4A:
undetectable		 5h5fA-1hz4A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jsx GLUCOSE-INHIBITED
DIVISION PROTEIN B

(Escherichia
coli) 		PF02527
(GidB) 		5 LEU A 199
ILE A 173
ASP A 171
ARG A 197
ALA A 163
 None
 1.05A 5h5fA-1jsxA:
1.6		 5h5fA-1jsxA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k8g TELOMERE-BINDING
PROTEIN ALPHA
SUBUNIT

(Sterkiella nova) 		PF02765
(POT1) 		5 PHE A 136
ILE A 120
ASP A 118
LEU A  83
ALA A  98
 None
 1.17A 5h5fA-1k8gA:
undetectable		 5h5fA-1k8gA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kpl PUTATIVE CLC FAMILY,
CHLORINE TRANSPORT
PROTEIN

(Salmonella
enterica) 		PF00654
(Voltage_CLC) 		5 LEU A 423
ILE A 391
GLY A 387
LEU A 252
ALA A 247
 None
None
None
OCT  A 502 ( 4.9A)
None
 1.04A 5h5fA-1kplA:
undetectable		 5h5fA-1kplA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2w MANNITOL
DEHYDROGENASE

(Pseudomonas
fluorescens) 		PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C) 		5 LEU A 412
GLY A 378
ASP A 377
LEU A 312
ALA A 409
 None
 1.13A 5h5fA-1m2wA:
undetectable		 5h5fA-1m2wA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3q QUINOLINE
2-OXIDOREDUCTASE
LARGE SUBUNIT

(Pseudomonas
putida) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 LEU B 571
GLY B 588
ASP B 587
LEU B 575
MET B 600
 None
 1.02A 5h5fA-1t3qB:
undetectable		 5h5fA-1t3qB:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u10 PENICILLIN-INSENSITI
VE MUREIN
ENDOPEPTIDASE

(Escherichia
coli) 		PF03411
(Peptidase_M74) 		5 PRO A 217
ILE A  45
GLY A  70
ASP A  49
ARG A 215
 None
 0.95A 5h5fA-1u10A:
undetectable		 5h5fA-1u10A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u61 HYPOTHETICAL PROTEIN

(Bacillus cereus) 		PF00636
(Ribonuclease_3) 		5 ILE A 103
GLY A  16
ASP A  17
ARG A  75
ALA A   4
 None
 1.03A 5h5fA-1u61A:
undetectable		 5h5fA-1u61A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ue8 367AA LONG
HYPOTHETICAL
CYTOCHROME P450

(Sulfurisphaera
tokodaii) 		PF00067
(p450) 		5 LEU A 207
ILE A 124
ASP A 142
LEU A 206
ALA A 210
 None
None
None
HEM  A 410 ( 4.8A)
HEM  A 410 (-4.2A)
 1.11A 5h5fA-1ue8A:
undetectable		 5h5fA-1ue8A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ujn DEHYDROQUINATE
SYNTHASE

(Thermus
thermophilus) 		PF01761
(DHQ_synthase) 		5 PRO A 273
GLY A 178
ASP A 183
LEU A 271
ALA A 259
 None
 1.15A 5h5fA-1ujnA:
undetectable		 5h5fA-1ujnA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vs1 3-DEOXY-7-PHOSPHOHEP
TULONATE SYNTHASE

(Aeropyrum
pernix) 		PF00793
(DAHP_synth_1) 		5 LEU A  69
GLY A 238
ASP A 237
LEU A 103
ALA A  66
 None
 1.12A 5h5fA-1vs1A:
undetectable		 5h5fA-1vs1A:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8s FRUCTOSE-BISPHOSPHAT
E ALDOLASE CLASS I

(Thermoproteus
tenax) 		PF01791
(DeoC) 		5 LEU A 104
ILE A  76
GLY A  57
ASP A  56
ALA A  65
 None
 1.04A 5h5fA-1w8sA:
undetectable		 5h5fA-1w8sA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aps PROTEIN (CU,ZN
SUPEROXIDE
DISMUTASE)

(Actinobacillus
pleuropneumoniae) 		PF00080
(Sod_Cu) 		5 LEU A 130
GLY A 105
ASP A 106
ARG A 126
LEU A  15
 None
None
ZN  A 400 (-2.2A)
None
None
 1.16A 5h5fA-2apsA:
undetectable		 5h5fA-2apsA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cx9 ACYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 LEU A  66
GLY A 247
ASP A 246
ARG A  69
LEU A  70
 None
 1.14A 5h5fA-2cx9A:
undetectable		 5h5fA-2cx9A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4e 5-CARBOXYMETHYL-2-HY
DROXYMUCONATE
SEMIALDEHYDE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00171
(Aldedh) 		5 LEU A 195
PHE A 222
ILE A  31
ARG A  68
ALA A 209
 None
 1.12A 5h5fA-2d4eA:
3.4		 5h5fA-2d4eA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i76 HYPOTHETICAL PROTEIN

(Thermotoga
maritima) 		PF10728
(DUF2520) 		5 PHE A 124
GLY A 128
ASP A 129
ARG A 100
ALA A 140
 None
 1.04A 5h5fA-2i76A:
undetectable		 5h5fA-2i76A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ime 2-HYDROXYCHROMENE-2-
CARBOXYLATE
ISOMERASE

(Pseudomonas
putida) 		PF01323
(DSBA) 		5 GLY A 174
ASP A 175
ARG A 183
LEU A 184
MET A 171
 None
 1.13A 5h5fA-2imeA:
undetectable		 5h5fA-2imeA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kaf NON-STRUCTURAL
PROTEIN 3

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF12124
(Nsp3_PL2pro) 		5 LEU A  33
PHE A  32
GLY A  54
ARG A  35
LEU A  66
 None
 1.01A 5h5fA-2kafA:
undetectable		 5h5fA-2kafA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1z PHOSPHORIBOSYLTRANSF
ERASE

(Corynebacterium
diphtheriae) 		PF00156
(Pribosyltran) 		5 LEU A  10
ILE A 168
ASP A 149
LEU A  14
ALA A  38
 None
 0.95A 5h5fA-2p1zA:
undetectable		 5h5fA-2p1zA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyw UNCHARACTERIZED
PROTEIN

(Arabidopsis
thaliana) 		PF01636
(APH) 		5 LEU A 177
ILE A 235
ARG A 230
ARG A 179
LEU A 180
 None
None
None
None
SR1  A 998 ( 4.9A)
 1.15A 5h5fA-2pywA:
undetectable		 5h5fA-2pywA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6z UPF0341 PROTEIN IN
RSP 3' REGION

(Neisseria
gonorrhoeae) 		PF04445
(SAM_MT) 		5 ILE A 125
GLY A 124
ASP A 123
ARG A 126
ALA A  92
 None
 1.16A 5h5fA-2r6zA:
1.8		 5h5fA-2r6zA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rb9 HYPE PROTEIN

(Escherichia
coli) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 LEU A 275
ILE A 303
GLY A 304
ARG A 220
LEU A 219
 None
 1.10A 5h5fA-2rb9A:
undetectable		 5h5fA-2rb9A:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yyl 4-HYDROXYPHENYLACETA
TE-3-HYDROXYLASE

(Thermus
thermophilus) 		PF03241
(HpaB)
PF11794
(HpaB_N) 		5 GLY A 443
ASP A 444
ARG A 447
LEU A 358
ALA A 285
 FAD  A 600 (-3.3A)
FAD  A 600 (-3.0A)
FAD  A 600 (-3.3A)
None
None
 0.78A 5h5fA-2yylA:
undetectable		 5h5fA-2yylA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ziu MUS81 PROTEIN
CROSSOVER JUNCTION
ENDONUCLEASE EME1

(Danio rerio;
Homo sapiens) 		PF02732
(ERCC4)
PF02732
(ERCC4) 		5 LEU B 359
GLY A 456
ASP A 455
LEU B 361
ALA B 421
 None
 1.12A 5h5fA-2ziuB:
undetectable		 5h5fA-2ziuB:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctt MALTASE-GLUCOAMYLASE

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		5 LEU A 401
PRO A 400
ILE A 390
GLY A 385
ASP A 387
 None
 1.12A 5h5fA-3cttA:
undetectable		 5h5fA-3cttA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3l ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE

(Homo sapiens) 		PF00305
(Lipoxygenase) 		5 PHE A 534
GLY A 608
ARG A 628
LEU A 652
ALA A 538
 None
 1.04A 5h5fA-3d3lA:
undetectable		 5h5fA-3d3lA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e35 UNCHARACTERIZED
PROTEIN SCO1997

(Streptomyces
coelicolor) 		PF09754
(PAC2) 		5 LEU A 221
ILE A 156
GLY A 155
LEU A 239
ALA A 217
 None
 1.01A 5h5fA-3e35A:
undetectable		 5h5fA-3e35A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eeq PUTATIVE COBALAMIN
BIOSYNTHESIS PROTEIN
G HOMOLOG

(Sulfolobus
solfataricus) 		PF01890
(CbiG_C)
PF11760
(CbiG_N) 		5 ILE A 235
GLY A 234
ASP A 233
ARG A 256
ALA A 302
 None
None
None
None
SO4  A   3 (-3.8A)
 1.10A 5h5fA-3eeqA:
2.1		 5h5fA-3eeqA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gl1 HEAT SHOCK PROTEIN
SSB1

(Saccharomyces
cerevisiae) 		PF00012
(HSP70) 		5 LEU A 240
ASP A 288
ARG A 265
LEU A 300
ALA A 273
 None
MG  A 703 ( 3.0A)
CL  A 711 ( 4.0A)
None
None
 1.10A 5h5fA-3gl1A:
undetectable		 5h5fA-3gl1A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6t MUCONATE
CYCLOISOMERASE

(Jannaschia sp.
CCS1) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 108
ILE A 270
ASP A 297
LEU A  40
ALA A 111
 None
 1.17A 5h5fA-3i6tA:
undetectable		 5h5fA-3i6tA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j26 CAPSID PROTEIN V20

(Mimivirus-dependent
virus Sputnik) 		no annotation 5 LEU A 180
PHE A 171
ASP A 161
ARG A  95
ALA A 174
 None
 1.17A 5h5fA-3j26A:
undetectable		 5h5fA-3j26A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mb2 4-OXALOCROTONATE
TAUTOMERASE FAMILY
ENZYME - BETA
SUBUNIT

(Chloroflexus
aurantiacus) 		no annotation 5 LEU B   3
ILE B  33
GLY B  34
LEU B  42
ALA B  25
 None
 1.13A 5h5fA-3mb2B:
undetectable		 5h5fA-3mb2B:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n4k RNA
METHYLTRANSFERASE

(Yersinia pestis) 		PF00588
(SpoU_methylase) 		5 LEU A  83
PHE A 104
ARG A 126
MET A 136
ALA A 141
 SAH  A 201 (-4.1A)
SAH  A 201 (-4.9A)
None
SAH  A 201 (-3.9A)
SAH  A 201 ( 4.0A)
 0.96A 5h5fA-3n4kA:
9.7		 5h5fA-3n4kA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nbe RICIN B-LIKE LECTIN

(Clitocybe
nebularis) 		PF14200
(RicinB_lectin_2) 		5 LEU A 139
ILE A 126
GLY A  34
ASP A  20
ALA A  13
 None
None
None
DLD  A 580 (-2.8A)
None
 0.86A 5h5fA-3nbeA:
undetectable		 5h5fA-3nbeA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3noq THIJ/PFPI FAMILY
PROTEIN

(Pseudomonas
fluorescens) 		PF01965
(DJ-1_PfpI) 		5 ILE A 156
GLY A 155
ASP A  17
LEU A  28
ALA A 163
 None
None
EDO  A 604 ( 4.6A)
None
None
 1.03A 5h5fA-3noqA:
undetectable		 5h5fA-3noqA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rre PUTATIVE
UNCHARACTERIZED
PROTEIN

(Thermotoga
maritima) 		PF01256
(Carb_kinase)
PF03853
(YjeF_N) 		5 LEU A 305
ILE A 314
GLY A 315
ASP A 342
ALA A 266
 None
None
None
MG  A 492 ( 4.1A)
None
 1.17A 5h5fA-3rreA:
2.1		 5h5fA-3rreA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rwl CYTOCHROME P450
ALKANE HYDROXYLASE 1
CYP153A7

(Sphingopyxis
macrogoltabida) 		PF00067
(p450) 		5 LEU A  96
ILE A  88
GLY A  87
ASP A  86
LEU A  98
 None
 1.16A 5h5fA-3rwlA:
undetectable		 5h5fA-3rwlA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tc8 LEUCINE
AMINOPEPTIDASE

(Parabacteroides
distasonis) 		PF04389
(Peptidase_M28) 		5 LEU A 219
GLY A 144
ASP A 143
LEU A 155
ALA A 121
 None
 0.81A 5h5fA-3tc8A:
undetectable		 5h5fA-3tc8A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tev GLYCOSYL HYROLASE,
FAMILY 3

(Deinococcus
radiodurans) 		PF00933
(Glyco_hydro_3) 		6 ILE A 256
GLY A 254
ASP A 253
ARG A 247
LEU A 131
ALA A 174
 None
 1.30A 5h5fA-3tevA:
undetectable		 5h5fA-3tevA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u1k POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE 1, MITOCHONDRIAL

(Homo sapiens) 		PF00013
(KH_1)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		5 GLY A 198
ASP A 197
ARG A 192
LEU A 216
ALA A 244
 None
 1.13A 5h5fA-3u1kA:
undetectable		 5h5fA-3u1kA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v98 ARACHIDONATE
5-LIPOXYGENASE

(Homo sapiens) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		5 PHE A 544
GLY A 618
ARG A 638
LEU A 662
ALA A 548
 None
 1.03A 5h5fA-3v98A:
undetectable		 5h5fA-3v98A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhy 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Mycobacterium
tuberculosis) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		5 LEU A 101
ILE A 147
GLY A 145
LEU A 275
ALA A 274
 None
 1.09A 5h5fA-3zhyA:
undetectable		 5h5fA-3zhyA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4btp P1

(Pseudomonas
phage phi8) 		no annotation 5 LEU A 256
ILE A 307
GLY A 311
ARG A 254
ALA A 260
 None
 1.12A 5h5fA-4btpA:
undetectable		 5h5fA-4btpA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c30 DNA HELICASE II

(Deinococcus
radiodurans) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		5 LEU A 414
ILE A 124
ASP A 195
LEU A 404
ALA A 413
 None
 1.17A 5h5fA-4c30A:
undetectable		 5h5fA-4c30A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iwh 3-ISOPROPYLMALATE
DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00180
(Iso_dh) 		5 ILE A 259
GLY A 260
ASP A 333
LEU A 122
ALA A 102
 None
 1.05A 5h5fA-4iwhA:
2.1		 5h5fA-4iwhA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j2u ENOYL-COA HYDRATASE

(Rhodobacter
sphaeroides) 		PF16113
(ECH_2) 		5 LEU A 105
ILE A 132
GLY A 170
ASP A 173
ARG A 182
 None
 1.12A 5h5fA-4j2uA:
undetectable		 5h5fA-4j2uA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l1k D-ALANINE--D-ALANINE
LIGASE

(Xanthomonas
oryzae) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		5 LEU A  40
PHE A  57
GLY A  12
LEU A   8
ALA A  24
 None
 1.11A 5h5fA-4l1kA:
undetectable		 5h5fA-4l1kA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lvo SUBTILISIN-LIKE
SERINE PROTEASE

(Plasmodium
falciparum) 		PF00082
(Peptidase_S8) 		5 LEU A 570
GLY A 345
ASP A 347
LEU A 645
ALA A 584
 None
 1.07A 5h5fA-4lvoA:
undetectable		 5h5fA-4lvoA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9p FILAMIN-A

(Homo sapiens) 		PF00630
(Filamin) 		5 ILE A 663
GLY A 588
ARG A 664
MET A 660
ALA A 644
 None
 1.16A 5h5fA-4m9pA:
undetectable		 5h5fA-4m9pA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mm0 P450-LIKE
MONOOXYGENASE

(Streptomyces
griseoviridis) 		PF00067
(p450) 		6 LEU A  46
ILE A 294
GLY A 295
ARG A  28
LEU A  27
ALA A  34
 None
 1.28A 5h5fA-4mm0A:
undetectable		 5h5fA-4mm0A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4osp OXYGENASE-REDUCTASE

(Streptomyces
fradiae) 		PF13561
(adh_short_C2) 		5 LEU A  94
GLY A 233
ASP A 234
ARG A 237
LEU A  91
 None
 1.10A 5h5fA-4ospA:
2.6		 5h5fA-4ospA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4py3 BARTONELLA EFFECTOR
PROTEIN (BEP)
SUBSTRATE OF VIRB
T4SS

(Bartonella sp.
1-1C) 		PF02661
(Fic) 		5 LEU A 170
PHE A 167
ILE A 214
LEU A 130
ALA A 142
 None
 1.12A 5h5fA-4py3A:
undetectable		 5h5fA-4py3A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4py3 BARTONELLA EFFECTOR
PROTEIN (BEP)
SUBSTRATE OF VIRB
T4SS

(Bartonella sp.
1-1C) 		PF02661
(Fic) 		5 PHE A 167
ILE A 214
ASP A 216
LEU A 130
ALA A 142
 None
 1.17A 5h5fA-4py3A:
undetectable		 5h5fA-4py3A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfk ABC TRANSPORTER
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Pseudoalteromonas
sp. SM9913) 		no annotation 5 LEU H 500
ILE H 421
GLY H 422
ARG H 425
LEU H 448
 None
 1.15A 5h5fA-4qfkH:
undetectable		 5h5fA-4qfkH:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qk3 CARBONIC ANHYDRASE 2

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 LEU A  79
ILE A  91
ASP A 130
LEU A  84
ALA A 142
 None
 1.14A 5h5fA-4qk3A:
undetectable		 5h5fA-4qk3A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qn9 N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D

(Homo sapiens) 		PF12706
(Lactamase_B_2) 		5 PRO A 212
PHE A 210
GLY A 283
ASP A 284
LEU A 230
 None
None
None
ZN  A 502 (-2.5A)
None
 1.16A 5h5fA-4qn9A:
undetectable		 5h5fA-4qn9A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1d UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		no annotation 5 PRO A  55
GLY A 137
ASP A 115
MET A 140
ALA A 143
 None
 1.00A 5h5fA-4r1dA:
1.8		 5h5fA-4r1dA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rg6 CELL DIVISION CYCLE
PROTEIN 27 HOMOLOG

(Homo sapiens) 		PF00515
(TPR_1)
PF12895
(ANAPC3)
PF13181
(TPR_8) 		5 LEU A  41
ILE A  12
ASP A  23
LEU A  60
ALA A  45
 None
 1.17A 5h5fA-4rg6A:
undetectable		 5h5fA-4rg6A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rs1 GRANULOCYTE-MACROPHA
GE
COLONY-STIMULATING
FACTOR RECEPTOR
SUBUNIT ALPHA

(Homo sapiens) 		PF09240
(IL6Ra-bind) 		5 ILE B 144
GLY B 166
ARG B 142
ARG B 170
LEU B 191
 None
 1.13A 5h5fA-4rs1B:
undetectable		 5h5fA-4rs1B:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tzn PROTEIN HTP-2

(Caenorhabditis
elegans) 		PF02301
(HORMA) 		5 LEU A 141
PHE A 153
GLY A 103
ASP A 102
ALA A 139
 None
 1.05A 5h5fA-4tznA:
undetectable		 5h5fA-4tznA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uc7 NUCLEOPROTEIN

(Human
orthopneumovirus) 		PF03246
(Pneumo_ncap) 		5 LEU A 161
PHE A 243
ARG A 238
LEU A 164
ALA A 165
 None
 1.17A 5h5fA-4uc7A:
undetectable		 5h5fA-4uc7A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uw2 CSM1

(Thermococcus
onnurineus) 		PF01966
(HD) 		6 LEU A 281
ILE A 333
GLY A 238
ASP A 239
LEU A 283
ALA A 300
 None
 1.20A 5h5fA-4uw2A:
undetectable		 5h5fA-4uw2A:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v15 D-THREONINE ALDOLASE

(Achromobacter
xylosoxidans) 		PF01168
(Ala_racemase_N)
PF14031
(D-ser_dehydrat) 		5 PRO A  56
ARG A  69
LEU A 248
MET A  43
ALA A  47
 None
 1.16A 5h5fA-4v15A:
undetectable		 5h5fA-4v15A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w5w RIBULOSE
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E ACTIVASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00004
(AAA) 		5 LEU A 290
ILE A 284
GLY A 110
LEU A 342
ALA A 289
 None
None
SO4  A 401 (-3.4A)
None
None
 1.16A 5h5fA-4w5wA:
undetectable		 5h5fA-4w5wA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio cholerae) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 ILE A 150
GLY A 152
ASP A  96
ARG A 151
ALA A 171
 None
 1.12A 5h5fA-4xoxA:
1.3		 5h5fA-4xoxA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zhs ASPARTATE
SEMIALDEHYDE
DEHYDROGENASE

(Trichophyton
rubrum) 		no annotation 5 PRO D 162
ILE D 322
GLY D 320
LEU D 159
ALA D 255
 None
 0.91A 5h5fA-4zhsD:
undetectable		 5h5fA-4zhsD:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zsx UNCHARACTERIZED
FUSION PROTEIN

(Pseudomonas
aeruginosa;
Aquifex
aeolicus) 		PF06557
(DUF1122) 		5 LEU A 218
GLY A 273
ASP A 274
ARG A 216
ALA A 232
 None
 1.14A 5h5fA-4zsxA:
undetectable		 5h5fA-4zsxA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG

(Cupriavidus
necator) 		PF00374
(NiFeSe_Hases) 		5 LEU C 268
PRO C 539
GLY C 393
ASP C 571
ARG C 501
 None
None
None
None
NFU  C 701 (-4.6A)
 1.09A 5h5fA-5aa5C:
undetectable		 5h5fA-5aa5C:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5apg TSR3

(Vulcanisaeta
distributa) 		PF04034
(Ribo_biogen_C) 		5 LEU A  45
PRO A  47
ARG A  92
LEU A  93
ALA A 115
 EEM  A1185 (-3.9A)
EEM  A1185 (-3.9A)
None
EEM  A1185 (-3.9A)
EEM  A1185 (-3.4A)
 0.78A 5h5fA-5apgA:
7.3		 5h5fA-5apgA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5az3 ABC-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT

(Corynebacterium
glutamicum) 		PF01497
(Peripla_BP_2) 		5 PHE A 248
GLY A 252
ASP A 253
LEU A 286
ALA A 281
 None
 1.17A 5h5fA-5az3A:
undetectable		 5h5fA-5az3A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp7 SAM-DEPENDENT
METHYLTRANSFERASE

(Geobacter
sulfurreducens) 		PF13847
(Methyltransf_31) 		5 LEU A  42
ILE A  62
GLY A  38
ARG A  88
ALA A 105
 None
 1.08A 5h5fA-5bp7A:
undetectable		 5h5fA-5bp7A:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c54 DIHYDRODIPICOLINATE
SYNTHASE/N-ACETYLNEU
RAMINATE LYASE

(Corynebacterium
glutamicum) 		PF00701
(DHDPS) 		5 LEU A 104
GLY A  42
ASP A  41
LEU A 133
ALA A 101
 None
 0.94A 5h5fA-5c54A:
2.7		 5h5fA-5c54A:
21.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5c77 PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1

(Saccharomyces
cerevisiae) 		PF04252
(RNA_Me_trans) 		7 LEU A  83
PRO A  85
PHE A 104
ARG A 132
LEU A 133
MET A 138
ALA A 143
 SAH  A 301 (-4.5A)
SAH  A 301 (-3.8A)
SAH  A 301 (-4.8A)
None
SAH  A 301 (-4.0A)
SAH  A 301 (-4.9A)
SAH  A 301 ( 4.0A)
 0.34A 5h5fA-5c77A:
29.1		 5h5fA-5c77A:
91.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d8w ENDOGLUCANASE

(Ganoderma
lucidum) 		PF00150
(Cellulase) 		5 ILE A 158
GLY A 160
ASP A 118
ARG A  76
ALA A 190
 None
 1.02A 5h5fA-5d8wA:
undetectable		 5h5fA-5d8wA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dzz DESMOPLAKIN

(Homo sapiens) 		PF00681
(Plectin) 		5 LEU A2350
GLY A2256
ASP A2252
LEU A2367
ALA A2297
 None
 1.13A 5h5fA-5dzzA:
undetectable		 5h5fA-5dzzA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e78 BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE

(Bacillus
megaterium) 		PF00067
(p450) 		5 LEU A 353
PHE A  67
GLY A 394
LEU A  52
ALA A  61
 None
None
HEM  A 501 (-4.0A)
None
None
 1.09A 5h5fA-5e78A:
undetectable		 5h5fA-5e78A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ej1 PUTATIVE CELLULOSE
SYNTHASE

(Rhodobacter
sphaeroides) 		PF03170
(BcsB) 		5 GLY B 276
ASP B 275
ARG B 257
LEU B 184
ALA B 188
 None
 1.11A 5h5fA-5ej1B:
undetectable		 5h5fA-5ej1B:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eku ARGININE
N-METHYLTRANSFERASE,
PUTATIVE

(Trypanosoma
brucei) 		PF06325
(PrmA) 		5 LEU A 184
PHE A 273
ILE A 102
GLY A 103
LEU A 179
 None
None
SAH  A 401 (-4.9A)
SAH  A 401 (-3.0A)
None
 1.11A 5h5fA-5ekuA:
1.9		 5h5fA-5ekuA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fl7 ATP SYNTHASE SUBUNIT
BETA

(Yarrowia
lipolytica) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		5 LEU D 175
PRO D 177
ASP D 392
LEU D 174
ALA D 402
 None
 1.17A 5h5fA-5fl7D:
undetectable		 5h5fA-5fl7D:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ft6 CYSTEINE DESULFURASE
CSDA

(Escherichia
coli) 		PF00266
(Aminotran_5) 		5 LEU A 372
PHE A 331
GLY A 174
LEU A 352
ALA A 374
 None
 1.14A 5h5fA-5ft6A:
undetectable		 5h5fA-5ft6A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw5 T-COMPLEX PROTEIN 1
SUBUNIT THETA

(Saccharomyces
cerevisiae) 		PF00118
(Cpn60_TCP1) 		5 LEU q 117
ILE q  29
GLY q  26
ASP q  25
LEU q 122
 None
 1.15A 5h5fA-5gw5q:
2.0		 5h5fA-5gw5q:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw5 T-COMPLEX PROTEIN 1
SUBUNIT THETA

(Saccharomyces
cerevisiae) 		PF00118
(Cpn60_TCP1) 		5 LEU q 122
ILE q  29
GLY q  26
ASP q  25
ALA q 124
 None
 1.15A 5h5fA-5gw5q:
2.0		 5h5fA-5gw5q:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h4u ENDO-BETA-1,4-GLUCAN
ASE

(Cryptopygus
antarcticus) 		PF02015
(Glyco_hydro_45) 		5 ILE A 154
GLY A 153
ARG A  10
ARG A 174
ALA A 142
 None
 1.16A 5h5fA-5h4uA:
undetectable		 5h5fA-5h4uA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hv6 PHOSPHOENOLPYRUVATE
SYNTHASE

(Listeria
monocytogenes) 		PF01326
(PPDK_N) 		5 LEU A 138
ILE A 141
GLY A 142
ASP A 144
ALA A 115
 None
 1.08A 5h5fA-5hv6A:
undetectable		 5h5fA-5hv6A:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1r BURKHOLDERIA
PSEUDOMALLEI
SPHINGOSINE-1-PHOSPH
ATE LYASE BPSS2021

(Burkholderia
pseudomallei) 		PF00282
(Pyridoxal_deC) 		5 PRO A 276
ILE A 319
GLY A 316
ARG A 314
ALA A  71
 None
 1.15A 5h5fA-5k1rA:
undetectable		 5h5fA-5k1rA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5loh SERINE/THREONINE-PRO
TEIN KINASE
GREATWALL,SERINE/THR
EONINE-PROTEIN
KINASE GREATWALL

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 764
ILE A 153
GLY A 756
ARG A 155
LEU A 815
 None
 1.15A 5h5fA-5lohA:
undetectable		 5h5fA-5lohA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpv -

(-) 		no annotation 6 LEU D  80
ILE D  42
GLY D  43
ARG D  82
LEU D  83
ALA D  36
 None
 1.49A 5h5fA-5mpvD:
undetectable		 5h5fA-5mpvD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nwm NUCLEAR RECEPTOR
COACTIVATOR 1
SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 6

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		5 LEU A 313
ILE B 790
GLY A 270
ASP A 267
ALA A 310
 None
 1.13A 5h5fA-5nwmA:
undetectable		 5h5fA-5nwmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tbf TRANSLATION
ELONGATION FACTOR

(Vibrio cholerae) 		PF11826
(DUF3346) 		5 LEU A 268
ILE A 262
ASP A 279
LEU A 371
ALA A 231
 None
 1.09A 5h5fA-5tbfA:
undetectable		 5h5fA-5tbfA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ttx HYDROGENASE 2
MATURATION PEPTIDASE

(Thaumarchaeota
archaeon SCGC
AB-539-E09) 		PF01750
(HycI) 		5 PHE A  63
ILE A 123
ASP A 149
LEU A   8
ALA A  10
 None
 0.98A 5h5fA-5ttxA:
undetectable		 5h5fA-5ttxA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udb MINICHROMOSOME
MAINTENANCE PROTEIN
5

(Saccharomyces
cerevisiae) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		5 PRO 5 612
GLY 5 394
ARG 5 607
ARG 5 613
LEU 5 614
 None
 1.04A 5h5fA-5udb5:
undetectable		 5h5fA-5udb5:
15.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj7 ORIGIN RECOGNITION
COMPLEX SUBUNIT 5

(Homo sapiens) 		PF13191
(AAA_16)
PF14630
(ORC5_C) 		5 LEU E 124
PHE E 156
ILE E  35
ARG E  11
ALA E 127
 None
 0.95A 5h5fA-5uj7E:
undetectable		 5h5fA-5uj7E:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj7 ORIGIN RECOGNITION
COMPLEX SUBUNIT 5

(Homo sapiens) 		PF13191
(AAA_16)
PF14630
(ORC5_C) 		5 LEU E 124
PHE E 156
ILE E  35
GLY E  37
ALA E 127
 None
 1.08A 5h5fA-5uj7E:
undetectable		 5h5fA-5uj7E:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujm ORIGIN RECOGNITION
COMPLEX SUBUNIT 5

(Homo sapiens) 		PF13191
(AAA_16)
PF14630
(ORC5_C) 		5 LEU E 124
PHE E 156
ILE E  35
ARG E  11
ALA E 127
 None
 0.94A 5h5fA-5ujmE:
undetectable		 5h5fA-5ujmE:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujm ORIGIN RECOGNITION
COMPLEX SUBUNIT 5

(Homo sapiens) 		PF13191
(AAA_16)
PF14630
(ORC5_C) 		5 LEU E 124
PHE E 156
ILE E  35
GLY E  37
ALA E 127
 None
 1.08A 5h5fA-5ujmE:
undetectable		 5h5fA-5ujmE:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vat PENICILLIN-BINDING
PROTEIN ACTIVATOR
LPOA

(Haemophilus
influenzae) 		PF04348
(LppC) 		5 LEU A 262
ILE A 276
GLY A 520
ASP A 522
LEU A 316
 None
 1.16A 5h5fA-5vatA:
2.6		 5h5fA-5vatA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bwf -

(-) 		no annotation 5 LEU A 634
ILE A 647
GLY A 648
ARG A 629
ALA A 635
 None
 1.09A 5h5fA-6bwfA:
undetectable		 5h5fA-6bwfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f9n PRE-MRNA 3' END
PROCESSING PROTEIN
WDR33

(Homo sapiens) 		no annotation 5 LEU B 356
PHE B 358
ARG B 328
LEU B 381
ALA B 348
 None
 1.12A 5h5fA-6f9nB:
undetectable		 5h5fA-6f9nB:
undetectable